<?xml version="1.0" encoding="UTF-8"?>
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 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG0</accession>
    <name>E8MXG0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560411.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64041">
        <property type="protein sequence ID" value="BAJ64041"/>
        <property type="gene ID" value="ANT_20150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20150"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101319_0_0_0"/>
    <dbReference type="OMA" id="QEINEDY"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="247" mass="28620" checksum="42586848C87CECBE" modified="2011-04-05" version="1">MNHDPAPPVEYLPWDSNFFGKRIARIKRDTLTPPDVEAIFNWATEQQIDCLYLLANPESRETTLLAEQNRFHLTDVRITLEKKIFEEKEPVGVAIRPAVESDLPILKWIARQSHRDSRFYYDNHFATELCDKLFEIWIENSYNGFANQTLVIDIDSKPAGYLTCHVEDKEGRIGLLAVHPDHQGKALGSALVNASLVWFKMQGVTRVSVVTQGRNIRAQRLYQRCGFITRSLHIWYHWWNTPKGQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH3</accession>
    <name>E8MXH3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560424.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20280"/>
    <dbReference type="EnsemblBacteria" id="BAJ64054">
        <property type="protein sequence ID" value="BAJ64054"/>
        <property type="gene ID" value="ANT_20280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20280"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665013_0_0_0"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="403" mass="46459" checksum="3B37064809CEAEA2" modified="2011-04-05" version="1">MRIAIFHNLPSGGAKRALMEWTRRLAQRHEVHVYTLSTADHDYCDLRPYITHHIVYTFEPLPLFNSPFGRLNQWQRWKDLGRLAVLYQSLAQHIDKEGYDVVFTHPCKFTFIPILNIYLRSPTVYYLHEHFPNQVNRSIHRPYTRSEGVRKILDRVDPLIGLYQNQLRALQDLAVANTRLFLANSDFTLRQFQEHYSAPSALSRYGVNTEQFRPDENTPRERHLLSVGELSPRKGFDFLIQGLANIPDSNRPPLRLICNMQLEQEREYLCQLAEKSGVQMEILTNLNSEQLAQEYRKTRLVVYTPVQEPFGLVPLEAMACGTPVLGIAEGGVPETVIEGVTGRLSPRDPARFAEILLEMLKQPDLLRKMGQNGVDIVRKIWSWEQSTHTVEQHLLQASKAGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM0</accession>
    <name>E8MXM0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20750"/>
    <dbReference type="EnsemblBacteria" id="BAJ64101">
        <property type="protein sequence ID" value="BAJ64101"/>
        <property type="gene ID" value="ANT_20750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20750"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="OMA" id="TELYFTI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="284" mass="31533" checksum="1AB58C31DA6F6252" modified="2011-04-05" version="1">MKMLRIVTDGATDMPASWIEEYDINVLPLRISVGEKLITPGKGFSFEDFYRLIRETRIFPKTSLPSPGEVVNFYRQIAKQGDTILSLHLSSKLSGTYNTIKMAAEELKNEFQIHVFDSNAGSAAVGFMCREARLMAQAGLPLQTILERMDRIRNNLTVIFTLDSLEFAKLSGRINALQSALASLLNVKPVIILKEGLLEMAEKVRTRHRALDYIINVVKNRMGSMPINIAIVHAADLPTAQQLKERITQMLNVKEAIITDLSIPVASHLGPGTVGIVAYPANEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN8</accession>
    <name>E8MXN8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560489.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64119">
        <property type="protein sequence ID" value="BAJ64119"/>
        <property type="gene ID" value="ANT_20930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20930"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_0"/>
    <dbReference type="OMA" id="DDGANPF"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="375" mass="42703" checksum="4B16F79B3697EACE" modified="2011-04-05" version="1">MRIAFVADSYKPYISGVTHCITLWKRVLEQWGHEVYVVSFGDPSYNPDEDHVVYSPGIALPNGFYLGTRFSSRVQSLLEGMDVVHLNHPFLTGPLVARMLSGRQVPLVFTNHTRYDLYFRYYLPFIPEHLQKPFLRKTLASFYKQMQRVIFPSRSVQEMLARLALDVQGVIIPNGIEVERLRQGQKERCPLYAQLLGKKVILSLGRLTAEKNPRFLLQAFLNHLDSFPNTCLVFAGDGKERERLEHMVTVRNVQDRVIFAGNVPYDQVPDYLAIADVFVTASLSEVHPLTVMEAQAAGVPVVAVQAPGVDEIVADGRTGFLTPLDEHLFAGKLASLCRDEDLRTQFSRQTLAHSESFRVEHTVRRMLEEYERVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR4</accession>
    <name>E8MXR4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4268 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560515.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64145">
        <property type="protein sequence ID" value="BAJ64145"/>
        <property type="gene ID" value="ANT_21190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21190"/>
    <dbReference type="eggNOG" id="COG1637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064448_0_0_0"/>
    <dbReference type="OMA" id="FSVELYI"/>
    <dbReference type="OrthoDB" id="1489067at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025364">
        <property type="entry name" value="DUF4268"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14088">
        <property type="entry name" value="DUF4268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4268" evidence="1">
        <location>
            <begin position="170"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="311" mass="35384" checksum="1E9ECE1EA541D208" modified="2011-04-05" version="1">MNPIARLTRVPLRDVWHHEALNFTRWLAENLDLLSDPTGLRLSLVEAEAAAGDFAVDILTEDADGNLVVIENQLERTDHDHLGKLITYMSNHDAKTAIWITSQPRPEHEKAVHWLNETLPDDTSFYLLQVEAVRIDNSPPAPLFTVIAGPSAESRQIGEQRKELARRHILRMEFWDGLLKKARQKSTLFANISPGKDHWISTGAGKSGLTWAYVVLKDHARVELYIDTADSEKNKHYFDALLQHKEQIEASFGAPLEWQRLDEKRAARIAYLIRGHGGLPNQENWDALQDAMIDAMVRLENALKPHLSRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS4</accession>
    <name>E8MXS4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21290</name>
        <name evidence="3" type="ordered locus">ANT_23940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="2">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560525.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21290"/>
    <dbReference type="EnsemblBacteria" id="BAJ64155">
        <property type="protein sequence ID" value="BAJ64155"/>
        <property type="gene ID" value="ANT_21290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64420">
        <property type="protein sequence ID" value="BAJ64420"/>
        <property type="gene ID" value="ANT_23940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21290"/>
    <dbReference type="KEGG" id="atm:ANT_23940"/>
    <dbReference type="HOGENOM" id="CLU_680861_0_0_0"/>
    <dbReference type="OrthoDB" id="11151at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="404" mass="44820" checksum="D6B51CD29A058AC0" modified="2011-04-05" version="1">MAADDLRLKMLDDLLTAERGFRDMAERKVRALVGVLTELAYRLDGERLERMRQLDPGAPGTWKPEDWRSFFLAVSLTPQAGWGKSNGNGNGNGHAAEIAALQAKIAALERELALAKASPYQRRVDVDNPLLPAAPPPVPVASEGRLAGFVMPKIPRAYEYRWQVRGQMSRADEELHLKRRGMVLKCLAEGLNVQVEIGRYVGDATGAQYRSGAIRRVFEALEESGLIVRQTLSMSVTGNMPTRLAVARLSEEGRQFCRALGWQVVEGEWERLLKDHEGEKQEGHTLAVLLFATAARLRGWTVEILPEVQGNARPDLCISKDGQRGYVEVETGTRLHEGNAKWRMNAELNGGRVMLVARNVEERGVLAADCRHVAAHGCATDVETLIAGKFAEVNEEDPLWAEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX9</accession>
    <name>E8MXX9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560580.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64210">
        <property type="protein sequence ID" value="BAJ64210"/>
        <property type="gene ID" value="ANT_21840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21840"/>
    <dbReference type="HOGENOM" id="CLU_1253793_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="220" mass="23695" checksum="CFC3E2A3C4DF8406" modified="2011-04-05" version="1">MSGNKALAIHDLLEEQRTNTFVPFAEMPSAPNQWAAIACSPSWTARIPLRQPNRMNQIPTAVKYIKSCSDGGGGKGKPNSHPNQSQAIEANNTDNHMRHKIRQAGRVLMLCLLSIFLLISILLIGENIFQGTAGWNMIGTAAILGWLSSLSVNLEETSPKSAWINTVFISMIAVIIGCAAAVKGKIGIEESQRLALIIAAGTMATAARNYLDVAIVTDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY29</accession>
    <name>E8MY29_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560628.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22340"/>
    <dbReference type="EnsemblBacteria" id="BAJ64260">
        <property type="protein sequence ID" value="BAJ64260"/>
        <property type="gene ID" value="ANT_22340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22340"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027408_6_0_0"/>
    <dbReference type="OMA" id="LPMAEWF"/>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="460" mass="50716" checksum="E3BB6D1210319E15" modified="2011-04-05" version="1">MTLQPVKLSRSYKFVWGIAALGTSLLSGIYGALLPIFYQDYLGLSSRWIGMASFIYAIWNALNDPLFGYITDNTRSRWGRRIPYMRFTAPFLALTFVLVWLPPAQARESALFWWMLVTMLLYDTCYTIVGLVYSALLPEVTESDAERNDLQVSSSLFGLLGTLLGFMIPDFFRPKAGGSADFLPLQMSMVAVAVIAMLLIIATTLKVKERPEFTRVDQPIPLGEAIRFTLVNRSFLVLVAANFMSILMQSLLLGAIYYMADYLLQMNTLILLACIFIPLIIGVPLTRPIRERFGVVGAQQLLLIIAGVGLVLITIAPTFLIPICIAVAGFGLSGPQTLTNVLFAQVADEDELRSGVRREGAFFGVNALITKPAQSVALYLFPRILEATNFVSRGQNAGEIFLNQPESALFGIRLLGGLIPGVALLVGAGLLAFFPLRGEYLKKIQQAVLELHLKKKEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY99</accession>
    <name>E8MY99_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558442.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62044">
        <property type="protein sequence ID" value="BAJ62044"/>
        <property type="gene ID" value="ANT_00100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00100"/>
    <dbReference type="eggNOG" id="COG5658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093038_0_0_0"/>
    <dbReference type="OMA" id="VGIKTPW"/>
    <dbReference type="OrthoDB" id="2096549at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026272">
        <property type="entry name" value="SdpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37810:SF5">
        <property type="entry name" value="PTHR37810:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038959">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="216" mass="23957" checksum="B33E0992C656D903" modified="2011-04-05" version="1">MSKKAINITILLIVLAMLAFGAWAYPRLPEQAPSHWNARGEVDGTMPRIWAILLMPLMTLGIGYLLVYIPAIDPLGRNVEQFRRVYHLFIAGFCVYMAYVHGLTLLAGLGIAFNMTQMLLPAMGLLFIGIGSLLKHARPNWFIGIRTPWTLSSEAVWQETHRVGAWIFRAAGALSVLAAFLPPMLSPWVIMVAVLGAAFGTVVYSYVVYRRVNPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC1</accession>
    <name>E8MYC1_ANATU</name>
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        <submittedName>
            <fullName evidence="1">Putative esterase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558464.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00320"/>
    <dbReference type="EnsemblBacteria" id="BAJ62066">
        <property type="protein sequence ID" value="BAJ62066"/>
        <property type="gene ID" value="ANT_00320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00320"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037618_3_0_0"/>
    <dbReference type="OMA" id="SFFPNMT"/>
    <dbReference type="OrthoDB" id="1828423at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="259" mass="29626" checksum="E22516891D608D3F" modified="2011-04-05" version="1">MPLIHADFFSQALQLCVEVDVILPLRPWKGTGTRDDSRHPTLYLLHGLSDDHTIWQRRTSIERYVEEYDLAVVMPAVHRSFYTDMKAGYRYWTYVSEELPYVMRSLFPLSDKREDNFVAGLSMGGYGSFKLALSHPERFAAAASFSGALHMALAYQDPTPEWQAELNRIFGSLDEYQGSANDLFALAEQAKASGKPLPTLYAWCGTEDFLLPANHLFRDHAEKLGLPLTYREGPGDHSWKYWDEQIQVFLQMLPLKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF0</accession>
    <name>E8MYF0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558493.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00610"/>
    <dbReference type="EnsemblBacteria" id="BAJ62095">
        <property type="protein sequence ID" value="BAJ62095"/>
        <property type="gene ID" value="ANT_00610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00610"/>
    <dbReference type="HOGENOM" id="CLU_536025_0_0_0"/>
    <dbReference type="OrthoDB" id="1736111at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="508" mass="55767" checksum="046DCD00517AC6CB" modified="2011-04-05" version="1">MVKSWQKILALILGSAVLAALTAWLSPGAFWRGFGASFLLIGGSALALFGLWRGMGGGKHLALWMTLAFVLRLGLGLFFSLAYPLWGYDEPEYNAGYVFRDAYHRDREAYAVALSGERLLFNPNLELGSDQYGGLGMLSALVYRTLSTDAHRPALVLILGAFFFALGVPFLYRAAQARLTERAAQIAVWIYLLYPDGLFFTASQMREPFMLGLLCVGLWAVILWREHPRAALTAGALAVAGMLFISTRSAVFVVGILVLLAWLEFTARHPGRGWKALGWLGILLAGGVAFALTWGWFREAAVYDRVLTLKASGRLAAFIADVGDRYILPTIVGYGLAQPVFPAALVEPAIPLAKVVILLRSAGWYALAPLLVYALWAGWRATSEDDQRLILWAAGAFWAWALISALRGGGDMTDNPRYRMLLLPLGGLAVGWALEFARRTADRWLGRILAVEGIFLAVFLQWYLSRYLHWGGRLSLPAMGALIAGLSALVLVGGWVYDRLRPPRPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI2</accession>
    <name>E8MYI2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558525.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00930"/>
    <dbReference type="EnsemblBacteria" id="BAJ62127">
        <property type="protein sequence ID" value="BAJ62127"/>
        <property type="gene ID" value="ANT_00930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00930"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026983_1_0_0"/>
    <dbReference type="OMA" id="WGGANEP"/>
    <dbReference type="OrthoDB" id="253949at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="68"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="586" mass="64616" checksum="82B5D1DA2C184617" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK3</accession>
    <name>E8MYK3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560706.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23130"/>
    <dbReference type="EnsemblBacteria" id="BAJ64339">
        <property type="protein sequence ID" value="BAJ64339"/>
        <property type="gene ID" value="ANT_23130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23130"/>
    <dbReference type="HOGENOM" id="CLU_2663059_0_0_0"/>
    <dbReference type="OrthoDB" id="2223964at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="75" mass="8129" checksum="0D32D964BF51A8A0" modified="2011-04-05" version="1">MAKKFKRSTSASRPQPAEATTPQATASGTGSISRRATASDFNPDYTPIIRDLKRIGTLAGTFFVVLIILSFILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP3</accession>
    <name>E8MYP3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64379">
        <property type="protein sequence ID" value="BAJ64379"/>
        <property type="gene ID" value="ANT_23530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23530"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881780_0_0_0"/>
    <dbReference type="OMA" id="ANWSESV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="90"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="315" mass="35069" checksum="EF43C7893961FA30" modified="2011-04-05" version="1">MKMNSKHAASLFLQSPQPSLEHLLITDVLEAIRFSKSPLLSAALTRWLTPPVREIARLARAFDEDVHRVGLHEAARRFLPQMIPLPVFKGGEDLPLQGPLLLLANHPGTIDALLVLSRVPRDDIKLVASDRPFFRALPAFSTYLIFSSRVDRLAKASVVRQAIRHLQSGGVLFLFPAGRLEPDPAREADKALQAINEWSSSIEAILSRAPSTQVQVAMVSNLITPNAMKHPFTKLQKDTYKARITAEVLQLWAQMQFKRIPPLTPQVVFSPVFSLQELQLLHESPWAAIQAIARNLIRLKSAPPFPVISPLTSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ9</accession>
    <name>E8MYQ9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hisI</name>
        <name evidence="9" type="ordered locus">ANT_23690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560761.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64395">
        <property type="protein sequence ID" value="BAJ64395"/>
        <property type="gene ID" value="ANT_23690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23690"/>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_5_0_0"/>
    <dbReference type="OMA" id="TGYRSCF"/>
    <dbReference type="OrthoDB" id="1842189at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="105" mass="11809" checksum="4A29E78A229F6FE0" modified="2011-04-05" version="1">MREIRFDEHGLIPAIVQDARTGQVLTLAYMNRESLQKTLELGETVFWSRSRQQFWHKGETSGNTQRVVKIMLDCDGDALLVQVIPAGPACHTGAVSCFFEELEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ47</accession>
    <name>E8MZ47_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558588.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62190">
        <property type="protein sequence ID" value="BAJ62190"/>
        <property type="gene ID" value="ANT_01560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01560"/>
    <dbReference type="HOGENOM" id="CLU_975367_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="31861" checksum="53A10C5D1E250F1E" modified="2011-04-05" version="1">MSTLRPLPPLQPLRPFPNLRETGQRVAQRVGDALQSRTNPAAGGRRRPPMPRRLPPDTALLGVGKDGLPVLLDLGDPTPGAVLILSDDRSARREILRGVLESGMQTNPPHRLQYLILSSQPERWWMWRSEGGYERHSLGIEALEAEPCTRWLKSLAELVEQRRMGMRGGPAVLILIDDLEAVMSLGYDAMVQLDWLIKQGAEASVWVLATAPASSTASLTRWMRLFKTRILGWTSDPGVYSTLPLIEENLPALEHREQFCVRLPEGWLTFELAGKPLPELSETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ48</accession>
    <name>E8MZ48_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01570</name>
        <name evidence="3" type="ordered locus">ANT_07140</name>
        <name evidence="4" type="ordered locus">ANT_27800</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="2">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558589.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01570"/>
    <dbReference type="EnsemblBacteria" id="BAJ62191">
        <property type="protein sequence ID" value="BAJ62191"/>
        <property type="gene ID" value="ANT_01570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62748">
        <property type="protein sequence ID" value="BAJ62748"/>
        <property type="gene ID" value="ANT_07140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64806">
        <property type="protein sequence ID" value="BAJ64806"/>
        <property type="gene ID" value="ANT_27800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01570"/>
    <dbReference type="KEGG" id="atm:ANT_07140"/>
    <dbReference type="KEGG" id="atm:ANT_27800"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728910_0_0_0"/>
    <dbReference type="OrthoDB" id="607377at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="136"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="379" mass="43701" checksum="B438D3BA8CB67690" modified="2011-04-05" version="1">MDKYIPMRSFMEEFFDDEITAAKAAEIGQAMLVARSLRLTEIAGKMRGGSAASYKRIQRFLQKVDPRAMLWRLFCEQAEYVIGDPTEIERPQAWKTEYVGTLKDGKTRGFWVLLLATPYRGRALPCGLLTYSSKTIAADRSSRNVNHVRAFAGLKDLLGERPLVLDREFSYLELLLNLVEEGVNFVIRLNLGHHPPRFWDAEGREVVLSLAPGEKVIHPSVWYKGKVCVNLIGVWKKGLAEPLWVMSNLEPERAWQVYLWRMKIEETFRDLKGLLGMTRLMNKRQENMEKMVAMLLLVYAIALLIGEGLRDRLYGSPNQLQENVDVVLHKTGKKWRRYSGLFILLKQKWWLPPREWQSIVKEALASFVAIVRPTVLTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ83</accession>
    <name>E8MZ83_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Shikimate kinase</fullName>
                <shortName evidence="6">SK</shortName>
                <ecNumber evidence="6">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">3-dehydroquinate synthase</fullName>
                <shortName evidence="7">DHQS</shortName>
                <ecNumber evidence="7">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">aroK</name>
        <name evidence="7 9" type="synonym">aroB</name>
        <name evidence="9" type="ordered locus">ANT_01920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="function">
        <text evidence="6">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="6"/>
    <dbReference type="EC" id="4.2.3.4" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558624.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01920"/>
    <dbReference type="EnsemblBacteria" id="BAJ62226">
        <property type="protein sequence ID" value="BAJ62226"/>
        <property type="gene ID" value="ANT_01920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01920"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_5_1_0"/>
    <dbReference type="OMA" id="VSIWLRC"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="8">
        <location>
            <begin position="236"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="298"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="338"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="521" mass="55913" checksum="C421658A10C340E7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZB4</accession>
    <name>E8MZB4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_02230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558655.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62257">
        <property type="protein sequence ID" value="BAJ62257"/>
        <property type="gene ID" value="ANT_02230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02230"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_1_0"/>
    <dbReference type="OMA" id="YTGIMTD"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="238"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="35332" checksum="619AE2D7C7830575" modified="2011-04-05" version="1">MNGLERYDSPAQALQHARRIRILTHIRPDGDAIGSMLGLGLSLQAAGKQVQMILPDGVPAPLRFLPGSSQIVRSAAEEADLLVVLDSSDLPRTGGLPENAQVDVNIDHHITNTRFARLNWVEPDAVATAAILAEQLPAWGFPLEKDAASALLAGIITDTIGFRTSNTTSKALRLAADLMDRGADLPELYRAALLLKSFEAVRFWGFGLERLQRKNGLFWTVLYQQDREATGYNGNDDADLINFLSSTECDIVVLFNEQKEGKVKVSWRSRPGIDVSALAVQFGGGGHPAAAGAEIPGTVEEVRQQVLAATEQLLRDAREMSKSNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM3</accession>
    <name>E8MZM3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">moaA</name>
        <name evidence="14" type="ordered locus">ANT_25450</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560926.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25450"/>
    <dbReference type="EnsemblBacteria" id="BAJ64571">
        <property type="protein sequence ID" value="BAJ64571"/>
        <property type="gene ID" value="ANT_25450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25450"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_0"/>
    <dbReference type="OMA" id="DYLRMSV"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ64571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="36376" checksum="B7904B3571ACA59C" modified="2011-04-05" version="1">MAYDRFGRNIHYLRISLTDHCNLRCVYCMPEDMTFRPAAEMLQDEELLLLVRIFASLGIDKIRLTGGEPTVRANIVSLVREISSTSGIRTVTMTTNGILLGKLAKPLKEAGLQRVNISLDTLDPAKFRRLTRWGKFEQVWEGIRAAEEAGLTPIKINAVVVRGYNEKDVVDLAKLTYEHGWQVRFIEMMPFAGATELQQTQVVTTCEMIERIEQALGKLEPVREGELDGEARVFRLPGARGEVGFISTVSMPFCASCTRARLTADGKLRLCLLREKEVDLLAPLRGGASPADLRRLILDGIWQKPWGHGLAEGSVPLNRVMNEIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR7</accession>
    <name>E8MZR7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_25890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560970.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25890"/>
    <dbReference type="EnsemblBacteria" id="BAJ64615">
        <property type="protein sequence ID" value="BAJ64615"/>
        <property type="gene ID" value="ANT_25890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25890"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_5_1_0"/>
    <dbReference type="OMA" id="IAYWAHA"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="58"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="232" mass="26213" checksum="F899C4606BC6AC10" modified="2011-04-05" version="1">MFPIKDTVHSRSFPVVMWLIIIANTLVFMLELSLGPYRLERFIFRYGLVPARFDLFDPFTWMPVFTHMFLHGGWVHFLSNMWTLFIFGDNVEDRMGSGRFLIFYLMGGVLAGLAQAFIDPTSRIPAIGASGAIAAVLGAYFLFFPGSRVITFIPVFFLPWFIEIPSVIYLGFWFISQLFSGVAALATTSGIASGGVAWWAHIGGFVAGLLLARPFAAGRRYRVWYPDEFFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT6</accession>
    <name>E8MZT6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558668.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02370"/>
    <dbReference type="EnsemblBacteria" id="BAJ62271">
        <property type="protein sequence ID" value="BAJ62271"/>
        <property type="gene ID" value="ANT_02370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02370"/>
    <dbReference type="eggNOG" id="ENOG502ZGH7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_656599_0_0_0"/>
    <dbReference type="OMA" id="QEYRCCP"/>
    <dbReference type="OrthoDB" id="1012936at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="455" mass="50217" checksum="85B047C4D7E525B0" modified="2011-04-05" version="1">MHTESGVTPYAEIPCCPDLKTSPTCDVLDFRRHLVFPTSVRTEQGQIVRVEVIFHVRFTRCSGPLALGDIVYSTTLLPGEKVRLATTDRRSRFSFDSESKLSYRSEQISEEQYRLRSLRAFMSDQNVEDRGGENFQEEGKWDFHGDASGSLGFFSVNADTNAKGSHSASSSRDYLREFRAHAEMSDNLSVEATRRAHSLSIGEVSSRTHVQGESEDHFESASREFSNPNKCHAVTFLFYRINKTEKIRFELVSIERRVLDPVALMPVPAAPYKPTGAVATVPQEVPATSTKRLEIQEIALASEARARSSQVGLANPQLLSTRFAAGVATAAVSAIPAAALGFQQPLSDEVRAKALAEVDAQLVKQGLIERVGGQVSKRIKAEIDYERETSIPTAGVIVKSCMDDCGICEPEVALREKLELERLELENKLLAKRIELLEKSQEYRCCPGGEGEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU2</accession>
    <name>E8MZU2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558674.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02430"/>
    <dbReference type="TCDB" id="9.B.151.2.2">
        <property type="family name" value="the uncharacterized 7 tms archaeal/bacterial protein (7-abp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62277">
        <property type="protein sequence ID" value="BAJ62277"/>
        <property type="gene ID" value="ANT_02430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02430"/>
    <dbReference type="eggNOG" id="ENOG5030PTP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100111_0_0_0"/>
    <dbReference type="OMA" id="YLTGAMH"/>
    <dbReference type="OrthoDB" id="1890953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="25820" checksum="592EE8878BA6818E" modified="2011-04-05" version="1">MTFFNTVLPFLSSAVSFVFAALVLRRFAQKGGAHLLLWGIGMVFYGIGGFCEGFYGAFGWNPLIFRLWYLFGAMLVAAWLGQGTVYLLVRRRGIAHALMILLALGSLFGAVRVFGAQLDPSLMTGGLHTGSELSGKAIITAGVRTLTPIFNLYGTLALVGGAGYSAFLFWRKRVLLHRTIGNVLIAVGALLPAFGGSFSRMGVPGALYISEFLGAVLLFAGFLRATTPLPQESATAVEAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV8</accession>
    <name>E8MZV8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558690.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62293">
        <property type="protein sequence ID" value="BAJ62293"/>
        <property type="gene ID" value="ANT_02590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02590"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393804_0_0_0"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="195" mass="22490" checksum="F2D2DD04BE343E4F" modified="2011-04-05" version="1">MPSRSSQEILAYLREYVRRYSPVDESEYPTGGLEIATFIRILFHIIKDLEETHVDDLELSGPRVNLLFRLLWEEERGNSQGLTPSELSHNQHVTRNTISALLNGLEEQGLIVRELDKEDRRLFRIKLTDKARQTLYRIIPERLVFIRALVSGLSVDEQQQLVALLAKLFDSIHEHRCPQGEVAVRDDGSSPLMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV9</accession>
    <name>E8MZV9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_02600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558691.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62294">
        <property type="protein sequence ID" value="BAJ62294"/>
        <property type="gene ID" value="ANT_02600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02600"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_0"/>
    <dbReference type="OMA" id="RYFEVMD"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="37"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="386"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="420"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="640" mass="70868" checksum="471CBB4CF24D11F9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW5</accession>
    <name>E8MZW5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB</name>
        <name evidence="6" type="ordered locus">ANT_02660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02660"/>
    <dbReference type="EnsemblBacteria" id="BAJ62300">
        <property type="protein sequence ID" value="BAJ62300"/>
        <property type="gene ID" value="ANT_02660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02660"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="WTAFFNT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="255" mass="28593" checksum="D6167314628F3EE8" modified="2011-04-05" version="1">MVISMDKIRIEHLSIRYSDGTESLRDINLSIPANQITVLFGPAGGGKSTLLRALNRLNDLADVQEVSGQILFNGINILDPKLNVVELRRKIGMVFSRPVVLPLSIYQNVSYGLELMGERRKSKLDEAVERALRRAALWDEVYDRLHDPANAISGGQQQRLCLARVLALEPEVILLDEPTSALDPVSTARIEGLMQEIKEQYTIVWVPHNVQQAARMADYAAFFLQGELVEHGVGETLFVKPRDQRTQDYVTGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N027</accession>
    <name>E8N027_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvC</name>
        <name evidence="12" type="ordered locus">ANT_03280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558759.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03280"/>
    <dbReference type="EnsemblBacteria" id="BAJ62362">
        <property type="protein sequence ID" value="BAJ62362"/>
        <property type="gene ID" value="ANT_03280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03280"/>
    <dbReference type="eggNOG" id="COG0059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_1_2_0"/>
    <dbReference type="OMA" id="KGMDWMY"/>
    <dbReference type="OrthoDB" id="188901at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="10"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="200"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="350" mass="38836" checksum="5FC06B333CB01775" modified="2011-04-05" version="1">MAKMDFAGVLEEVVTREEFPLSRAQEVLKDEVVAVLGYGVQGPAQALNMRDNGIKVIVGVTPGGRSWNKALQDGWVPGETLFSMEEAAERGTIVQYLVSDAAQKLTWERIRPCLKEGDALYFSHGFAVVYRDQTGVVPPPYVDVILVAPKGSGTSVRANFLAGSGINSSFAVEQDYTGRARERTLAVGIAIGSGYLFETTFQHEVYSDLTGERGVLMGALAGIMEAQYQTLRAHGHTPSEAFNETVEELTQSLIRLVAQNGMDWMYANCSTTAQRGALDWRHEFRDATLPVFERLYQSVASGAETRRVLEANSQPDYKEKLEAELREMRESEMWRAGALVRSLRPENWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N060</accession>
    <name>E8N060_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_03610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558792.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03610"/>
    <dbReference type="EnsemblBacteria" id="BAJ62395">
        <property type="protein sequence ID" value="BAJ62395"/>
        <property type="gene ID" value="ANT_03610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03610"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082941_2_0_0"/>
    <dbReference type="OMA" id="VRPWRYP"/>
    <dbReference type="OrthoDB" id="1607767at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025184">
        <property type="entry name" value="DUF4111"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13427">
        <property type="entry name" value="DUF4111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4111" evidence="2">
        <location>
            <begin position="165"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="266" mass="30687" checksum="092192D2F334B4FA" modified="2011-04-05" version="1">MDLPLPAFLEDYPEITFLLRELLEGMRNILKERLIGVYLEGSLANGGFDTASDVDFLAVTTEPIDEKTFQALYAMHERLATFPTPWAMELEGSYLPLSFLRDFDPEKRFHPNLERGRQERLKLTDHDWGWWTIHRHILYHRGIVLYGADPRTLYTPPTPEVLKHAMHAVISAWAQGLVENPQKMDSRGYQSYVVLSLCRVLYTLIHGEVVSKFQAMQWALDTLEPRWHGLIQRAWQGRMSPNGAPDVNELDETVAFIRHAMETVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N090</accession>
    <name>E8N090_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26130"/>
    <dbReference type="EnsemblBacteria" id="BAJ64639">
        <property type="protein sequence ID" value="BAJ64639"/>
        <property type="gene ID" value="ANT_26130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26130"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_0"/>
    <dbReference type="OMA" id="MERLNWH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="384" mass="43043" checksum="A3FA28F1BAD83443" modified="2011-04-05" version="1">MRKILIVSSEFPPGPGGIGTHAYQLSRHLARLNWQVLVVAPQDYVSPQEREAFNSSQPFAIHSLSRSGWRMLTAGYRLGEIWKCIRLYSPQAVIFSGEKMVWLAGVLKPFFRMAFLAVGHGTEFGKITGWQARITRWAFHRMDHLIAVSQYTRAKMETLGILSDRITVIPNGADEERFFPLPEKRLSSLRAKFNGNQSPILLTVGNVTDRKGQEVVIRALPKILSRFSDAQYWMVGLPTLRDKLEQVASELKVQDHVHFLGRLGNSELVEAYNACDIFIMASREMPDGDVEGFGIAILEAALCGKPSIGTLGTGTSEAIFHGYTGLLVPQNDPTALASAVISLLENKEYSRQLGQNAYHYVMAHATWEKRVLEYHHLLLQLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B5</accession>
    <name>E8N0B5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561018.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26380"/>
    <dbReference type="EnsemblBacteria" id="BAJ64664">
        <property type="protein sequence ID" value="BAJ64664"/>
        <property type="gene ID" value="ANT_26380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26380"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OMA" id="FPYLING"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="83"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="34547" checksum="14FE47972B7D1C4B" modified="2011-04-05" version="1">MQTAKPQSSFMSSLKKWWMKEASAYGFISGYALMFLIFIAIPVAVAILLSFTFFDTIQPPRFLALKNYITLLTQDDIFMRYVLPNTIQFAVIVGPGGYLLAFILAWMLAQLPKVPRTIFALILYSPSMTAGVAMTVVWQALFSGDQTGYLNSFLLSLNLIQEPIQWLQSPQYLMPIMIIVTLWSSMGVGFLAMLAGILEINPELYEAGSIDGIRNRFQEIIYITIPSMKPQMLFGAVMAIVATFQAGAIGVTLSGSNPTPQYAGQLIVNHIEDYGFLRYEMGYAAAVSVVLLLMVWFFARVANRLFRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0C2</accession>
    <name>E8N0C2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26450"/>
    <dbReference type="EnsemblBacteria" id="BAJ64671">
        <property type="protein sequence ID" value="BAJ64671"/>
        <property type="gene ID" value="ANT_26450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26450"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069366_1_0_0"/>
    <dbReference type="OMA" id="WGGGVFN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025117">
        <property type="entry name" value="DUF4037"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13228">
        <property type="entry name" value="DUF4037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4037" evidence="2">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="297" mass="33314" checksum="ACA2E4BAAAA1D682" modified="2011-04-05" version="1">MWSMLPGLSFLPEAKRQLLETLVERLSKIEGLVAVVLGGSYASGTFHEASDMDIGLYYEESAPFSIEDIRTVAQEAAENGNVTVTGFYEWGPWVNGGAWIHTPHGKVDFLYRNLNQVQRTIAEAREGIVHHDYDQQPTYGWYSVIYLAETQICIPLYDPEGRVSQLKQEVAPYPPKLKQKILADSLWSVEFTLLHARGFATQGDVYNTVGCLTRAASNLTQALFALNERYFIRDKKVMKTLAGFSILPLGYADTLQDILAYPGRRAAELIQSVQAMEQVWQSVVALPGVDYAPKFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J3</accession>
    <name>E8N0J3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NarL family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_27160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27160"/>
    <dbReference type="EnsemblBacteria" id="BAJ64742">
        <property type="protein sequence ID" value="BAJ64742"/>
        <property type="gene ID" value="ANT_27160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27160"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_0"/>
    <dbReference type="OMA" id="FCDALAM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="212" mass="23357" checksum="AC0AD1FD037A0608" modified="2011-04-05" version="1">MPEIRILLADDHTLVRRGIRLLLEGVPDFCVVGESASGEETLQKLQQSQPNVLLLDISMPDTNGLEILSRVLEISPAMVVIMLSMYKDGEYIARALQAGARGYLWKDAPDEELIRAIRVAMSGEIYLPPGVSMEHIQALIAAQPPVERLTAREKQVLALLASGLTTQAIAVRLGVSPKTVETHRSHVMSKLDLYDIASLTRFALRHGLIQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P9</accession>
    <name>E8N0P9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_04100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62444">
        <property type="protein sequence ID" value="BAJ62444"/>
        <property type="gene ID" value="ANT_04100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04100"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_3_0"/>
    <dbReference type="OMA" id="RRVQREF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="396" mass="45993" checksum="8233116F6689D70B" modified="2011-04-05" version="1">MASPGSNKRGTEILKMLLEKADVQGYLTTEDLMEAYPNVGEDHERFEAILLALRRHGVDIYDTEENEYPFPDEDIDGAFIEEDPVQTFDLNRISSDDTVGLYLKEMSRVPLLSSEEEVELAKRIERGRAAKKELTRNSARLSPQRRGELEAQIQDGESAREHLIKANTRLVVSIAKRYIGRGVPFLDLIQEGNLGLMKAVEKYEYQRGFRFSTYATWWIRQTITRSIADQGRTIRVPVHMVDRIRRLYRTTHEMEQKLGRTPTNEELADAIGIKASKVDWMMRVSWLPLSLESPINEDEEDSELGQFIEDQVTPSPMQTTYSNLLREKIQEVLDTLPAREARILRLRFGLENGRTYTLEEVGQKFGLTRERIRQIENKALRRLRHPRRARQLKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q9</accession>
    <name>E8N0Q9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_04200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558850.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04200"/>
    <dbReference type="EnsemblBacteria" id="BAJ62454">
        <property type="protein sequence ID" value="BAJ62454"/>
        <property type="gene ID" value="ANT_04200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04200"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_0"/>
    <dbReference type="OMA" id="DTPFENF"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228585" evidence="4">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="31"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="31"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="251" mass="27440" checksum="43B909F9B6769C32" modified="2011-04-05" version="1">MKRFSVILWAMLIMALVFSACTPAQPSEKTKVRVATDATFPPFEMVDENTKQLTGFDVELMNAIAQKAGFEVEWINVGFDPMLAGIAECQYDMAIAAITITEERKASMDFSDPYINAGQIVTVRKETTDISGKNDLKGKKIGAQLGTTGAIEAEKIEGAEVKTYDSYDQAFLDLANGQIDAVIADYPTTLAFLATNPDKLKTVGEVFTDENYGVAFCKKKADLIPQVNAAIKALKEDGTIKKLEEKWLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R8</accession>
    <name>E8N0R8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_04290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558859.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04290"/>
    <dbReference type="EnsemblBacteria" id="BAJ62463">
        <property type="protein sequence ID" value="BAJ62463"/>
        <property type="gene ID" value="ANT_04290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04290"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101159_2_1_0"/>
    <dbReference type="OMA" id="SYATNCA"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228034" evidence="5">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="143" mass="14703" checksum="62F48E32D37BF80E" modified="2011-04-05" version="1">MKKSFWILLAVVVMSALVLAACGGGGGQATVERKAPPPEYAGKTNPYAGDAAAIAEGKELYNVNCATCHGETGAGDGPAGASLDPKPANLITAAKEASEDYEFWIVSEGGAAAGRSASMAAYKGVLTEDEIWKILAYTRTFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T6</accession>
    <name>E8N0T6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neutral metalloproteinase</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_04470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04470"/>
    <dbReference type="MEROPS" id="M04.023"/>
    <dbReference type="EnsemblBacteria" id="BAJ62481">
        <property type="protein sequence ID" value="BAJ62481"/>
        <property type="gene ID" value="ANT_04470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04470"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008590_0_1_0"/>
    <dbReference type="OMA" id="FCTIVPP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032475">
        <property type="entry name" value="Protealysin_N_PP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16485">
        <property type="entry name" value="PLN_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PLN_propep" evidence="10">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="8">
        <location>
            <begin position="92"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="9">
        <location>
            <begin position="183"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="378" mass="41562" checksum="483CDE2C6343502C" modified="2011-04-05" version="1">MSHRHPLFCVIPPYMLERIAEKGTEVQQERARQALALSEQMREQRQKVAVRAEALRTAGPAVRQRSVHSAQYLSNLPGVLVRAEGAAPSGDPAVDEAYDGSGATYDLFWDIYQRNSIDGAGMPLVSTVHYQQGYDNAFWNGYQMVYGDGDEDLPEEDRLFNRFTISLDVIGHELTHGVTQYTANLTYANQSGALNESFSDVFGSLVRQYQLRQTAAEADWIIGKGLFTANVNGVGLRSMKEPGTAYNDPILGKDPQPGHMRDYVTTTRDNGGVHINSGIPNHAFYYAAIEMGGYAWEKAGRIWYVTLRDRLRAGSTFQDAANLTFAVAGDLFGVNSLEQQAVKRAWSLVGIEVTGDGGGNGNQNPGCLDAFIRLLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V3</accession>
    <name>E8N0V3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558894.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04640"/>
    <dbReference type="EnsemblBacteria" id="BAJ62498">
        <property type="protein sequence ID" value="BAJ62498"/>
        <property type="gene ID" value="ANT_04640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04640"/>
    <dbReference type="eggNOG" id="COG2852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465352_0_0_0"/>
    <dbReference type="OMA" id="HPRANEW"/>
    <dbReference type="OrthoDB" id="1667672at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="184" mass="21143" checksum="970AA26B17AD6AD1" modified="2011-04-05" version="1">MPPAETDLILVAYLPAPRDWEIARVLGWYRIPLRHAPKVIEVDYLAFYQGAAFGEEHRWRIEYIAPVRGHELTTRAALLRDEPHHPRAHEEYYKVQLGAPERLPAPIPAGHWKRITFLYTTGERLLSARSLADLTVRDEEERQVLWRSLRDRAIQGGSYRAEDLPEVPLDPALLALLGGMDLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0X1</accession>
    <name>E8N0X1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-methylcitrate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prpD</name>
        <name evidence="5" type="ordered locus">ANT_04820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.79" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04820"/>
    <dbReference type="EnsemblBacteria" id="BAJ62516">
        <property type="protein sequence ID" value="BAJ62516"/>
        <property type="gene ID" value="ANT_04820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04820"/>
    <dbReference type="eggNOG" id="COG2079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021803_1_0_0"/>
    <dbReference type="OMA" id="ECTKHLG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="3">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="4">
        <location>
            <begin position="289"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="482" mass="52743" checksum="567BD8C6F7C251EA" modified="2011-04-05" version="1">MKMSGGHGQERGTFDPLMVEIADYVTRAQIDSSEAYHTARLCLMDSLGCALEALSYPACTKLLGPVVPGISVLNGAKVPGTPYQLDPVTAAFNLGAMIRWLDFNDTWLAAEWGHPSDNLGGILMSADWFSRQAVAAGKRPLMVRDVLTAMIKAHEIQGVLALENAFNRVGLDHVLLVRVASAAVVTGLLGGTHEDVLNAVSNAWVDGGSLRVYRHGANTGSRKSWAAGDATARGVRLALMALKGEMGYPGALTAPTWGFQDVFFKGQPIRLGRALGSYVMENVLFKVSFPAEFHAQTAVEAAFQLHPLVKDRLDEIEKVVITTHESALRIIDKKGPLRNPADRDHCIQYMTAIGLIFGRLTAEDYEDERAADPHIDALREKMVCVENPQYSRDYLDPDKRSIANAVQVFFRDGTATPQVAVEYPLGHRRRRAEALPLLEAKFRASLQRHLSPRQGAAIQALFANPGRLESVPVHEFVDLFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N150</accession>
    <name>E8N150_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561141.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64793">
        <property type="protein sequence ID" value="BAJ64793"/>
        <property type="gene ID" value="ANT_27670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27670"/>
    <dbReference type="eggNOG" id="COG4713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439832_0_0_0"/>
    <dbReference type="OrthoDB" id="1690184at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018674">
        <property type="entry name" value="DUF2142_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09913">
        <property type="entry name" value="DUF2142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="621" mass="69277" checksum="D8F99D922B3D51D9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A0</accession>
    <name>E8N1A0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GTP pyrophosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.5" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561189.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28170"/>
    <dbReference type="EnsemblBacteria" id="BAJ64843">
        <property type="protein sequence ID" value="BAJ64843"/>
        <property type="gene ID" value="ANT_28170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28170"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441915_0_0_0"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="545"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="618" mass="68981" checksum="BFDE0DBE30E304E4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P5</accession>
    <name>E8N1P5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_06160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559045.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06160"/>
    <dbReference type="EnsemblBacteria" id="BAJ62650">
        <property type="protein sequence ID" value="BAJ62650"/>
        <property type="gene ID" value="ANT_06160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06160"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_2_0_0"/>
    <dbReference type="OrthoDB" id="1808868at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="298" mass="32394" checksum="7F9F7EE284172AE2" modified="2011-04-05" version="1">MKAPRSKATWIRWAGTLLTLLLLGYLAAQQDWDTLRASFRQIEVWRWLAALGLTLLSRLAVALRWHVLLASAQPRLRLSQSMRLTFAGLFAANFLPTTIGGDVVRLAGAVQLRMDAALSTASLVADRLIGMAGMTLALPWGLARALDAGMPVLQSAFLSLPGLFQKIRAFAQNLLEHFRFWARKPAPLLISLGFTLVHMACLFSSIAILLEGQGQSIPWLTIAGIWSLVYFITLLPVSINGLGLQEVSSTLLYAHLGGISMEASLTLAVLLRALQMLASLPGALFVPDILAAREGKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R4</accession>
    <name>E8N1R4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlD</name>
        <name evidence="4" type="ordered locus">ANT_06350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559064.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06350"/>
    <dbReference type="EnsemblBacteria" id="BAJ62669">
        <property type="protein sequence ID" value="BAJ62669"/>
        <property type="gene ID" value="ANT_06350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06350"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_2_1_0"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="7"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="311" mass="34066" checksum="4A99F0F0D949333D" modified="2011-04-05" version="1">MGERRKRLLVTGASGLLGISLCLDAVGDFEVIGVVNSRRLAGAPFSQVQADFTQTGSAAKLIEEVRPDWVVHCAALADLDACEKNSALSARLNANLPGEVAEACYRSGARLVYISTDAVFDGERGGYREDDQPNPQSVYARDKWLGEQAVWQANPQAIVARVNFYGWSLLGQRSLAEKFYYTLAAGKGMMGFTDVYFCPLVNQHLGRILLEMLEKGLEGLYHVFSAECQSKYAFGVALAKRFGLDAGLIRPVSVQEAGLAARRSPNLTMRVEKLEAALGHAMPGQEEELEAFHRLYLEGYPQRLRAMVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S5</accession>
    <name>E8N1S5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acylneuraminate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_06460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acylneuraminate + CTP = a CMP-N-acyl-beta-neuraminate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11344"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:60073"/>
            <dbReference type="ChEBI" id="CHEBI:68671"/>
            <dbReference type="EC" id="2.7.7.43"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylneuraminate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CMP-NeuNAc synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.43" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559075.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06460"/>
    <dbReference type="EnsemblBacteria" id="BAJ62680">
        <property type="protein sequence ID" value="BAJ62680"/>
        <property type="gene ID" value="ANT_06460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06460"/>
    <dbReference type="eggNOG" id="COG1083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042930_0_2_0"/>
    <dbReference type="OrthoDB" id="1345588at2"/>
    <dbReference type="UniPathway" id="UPA00628"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008781">
        <property type="term" value="F:N-acylneuraminate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006054">
        <property type="term" value="P:N-acetylneuraminate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="411" mass="45492" checksum="49EE14A48CC2D5D7" modified="2011-04-05" version="1">MVDAKPEVLAIIPARGGSKGIPRKNIKSFAGHPLIAYSIAAGVQAESVTRVIVSTDDEEIATVAREYGAEVPFLRPEELAQDQTLDLPVFQHALRWLEEHEGYRPEVVVQLRPTSPVRPPHLVDEAVRILLEHPEADSVRGVVPAGQNPHKMWRIDPQSGMMKNLLDVPGVDEPYNAPRQILPPVYWQTGHIDAIRPRVIHGGSMSGRIILPVMVDPAYTVDIDTPKDWARSEWLVWYSDLEIVYPGRRRRPLPQRVDLVVLDFDGVMTDNRVWVNEEGREMVAANRSDSLGLGYLRREGVKVVVLSTETNPVVAARCRKLNLPVYQGVADKAAALPGILQEMGVLPENTIYVGNDSNDIPCFPLVACALVVEDAQTAARRAADIILTRKGGHGAVREVCDILLQRMGKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S6</accession>
    <name>E8N1S6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559076.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06470"/>
    <dbReference type="EnsemblBacteria" id="BAJ62681">
        <property type="protein sequence ID" value="BAJ62681"/>
        <property type="gene ID" value="ANT_06470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06470"/>
    <dbReference type="eggNOG" id="COG2089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040465_1_1_0"/>
    <dbReference type="OMA" id="CWDEEAV"/>
    <dbReference type="OrthoDB" id="674753at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NeuB" evidence="1">
        <location>
            <begin position="38"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="32836" checksum="02C42546933F7422" modified="2011-04-05" version="1">MAREVKIGNRMVGDGHPTYIAAEIGINHNGDLDIAKRMILEAKRAGVDSVKFQKRTPEICVPRDQWDIMRETPWGYISYIEYRRKMEFGLEEYKEIDRYCKEVGIDWFASVWDEPSVDFLEQFDPIAYKVPSAALTDHGLLSKLRETGRPVILSTGMSTMEQIRAAVSLLDMDKLVITHATSTYPCDPEELNLRVIEKLRAEFPCPIGYSGHEVGLIPSVVAVALGACLVERHITLDRAMWGSDQAASVEPQGFERLVKYIRVTEVALGDGVKRVYPSELSSLKKLRRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T6</accession>
    <name>E8N1T6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559086.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06570"/>
    <dbReference type="EnsemblBacteria" id="BAJ62691">
        <property type="protein sequence ID" value="BAJ62691"/>
        <property type="gene ID" value="ANT_06570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06570"/>
    <dbReference type="HOGENOM" id="CLU_487381_0_0_0"/>
    <dbReference type="OrthoDB" id="2161201at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="475" mass="53091" checksum="770D4490C6AAD3B2" modified="2011-04-05" version="1">MDPQLSRRRGYDAPRAVQWLAVGTFIMALAFLGYLGTYARYWADDYCYGLVARQSGLWQGLLEWYTLSGNRFSAFALVALLEPLGLNGVRFLPAAVLLLWVISGYVFLQELLGLFRVNFSRRGVLLLALMLVFYSVFLAPDRLQTLYWRMGTLHYTLPLPLMALTGWTLLRASRQSALQGWRRHLYLLLGLWTFFIGGLSETTGALQVTFLVLLGLGVWYKSASITKSFWIGWLSALAGALLALGVMLLSPSNAWRQAQLPPPPSLWALVTFTLRYVVDFVVYSLRGMPIPLGVLALTVWGLTILQSGERIPYKKGLAGIGLSLAIGALFLLSSMAPSVYAGLQYPTGRALMPARFIFIFTFMTIAWMLAGMMRSSPSVPGIWRWLAIGALLLGALYPMRGVLNLQAEYQGLSLRAQRWDERYAHITQALAQGERTVTVKETDVVMGLEDWNAGGNWVSTCAERYYGLEHLEIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V2</accession>
    <name>E8N1V2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559101.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06730"/>
    <dbReference type="EnsemblBacteria" id="BAJ62707">
        <property type="protein sequence ID" value="BAJ62707"/>
        <property type="gene ID" value="ANT_06730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06730"/>
    <dbReference type="eggNOG" id="ENOG5032ZRZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132548_3_0_0"/>
    <dbReference type="OMA" id="RAQWVRI"/>
    <dbReference type="OrthoDB" id="2071751at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="139" mass="15407" checksum="1616F83E42B568D8" modified="2011-04-05" version="1">MATNEERMKILKMVAEGKITAEEADQLLEALEESERVPGASRPGIPPMPSAPEMPPAPGRKPRWLHVRVTDTNTGRTRVNVRLPVSMINIGLKMGSKFAPEVDGLNMDELMRMIESGEIGQIVDVTDEEDGEHVEVYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V5</accession>
    <name>E8N1V5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V4R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559104.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06760"/>
    <dbReference type="EnsemblBacteria" id="BAJ62710">
        <property type="protein sequence ID" value="BAJ62710"/>
        <property type="gene ID" value="ANT_06760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06760"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465353_0_0_0"/>
    <dbReference type="OrthoDB" id="1171270at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041359">
        <property type="entry name" value="MetOD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18546">
        <property type="entry name" value="MetOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V4R" evidence="1">
        <location>
            <begin position="108"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="184" mass="21347" checksum="57AC96BEFA0F605B" modified="2011-04-05" version="1">MALSHFPEIHQVLLESTHEVLGKGQSGFLQPEEKTFLTELERLLTEQFGTLTGRGMAIRMGRSGFQTGLRRWGETLGFYSLDFRLMPFPRRVRFGLDQIARFLEERTSLQINIHEEPEHWIVEIRQMPSCTRSTSPVLCSLLMGMFQEFMQWQGSGRFFPVRETQCVAQGSPCCRFEISRKPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W2</accession>
    <name>E8N1W2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06830"/>
    <dbReference type="EnsemblBacteria" id="BAJ62717">
        <property type="protein sequence ID" value="BAJ62717"/>
        <property type="gene ID" value="ANT_06830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06830"/>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_1_2_0"/>
    <dbReference type="OMA" id="LFKNFAD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="2">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="201" mass="22367" checksum="61D2EE0C0A73BCE1" modified="2011-04-05" version="1">MSKMVEVVIDSVRVSLTNQQRIVVLREVNTERYLPIWIGPYEAEAITIALQEIEVARPQTHDLLKNVLNALNARLLRIEVVALRDEVFYGNLVVEVNGRILNIDSRPSDALALAVRAHVPILVSREVMDVAGVTPEDDLRSATSRTSSAPLAPPTPPTSSEAEVDTSEERLSVFEDFLANLNLDKLEDEEDEGDEDEKPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N246</accession>
    <name>E8N246_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_29670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561337.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64993">
        <property type="protein sequence ID" value="BAJ64993"/>
        <property type="gene ID" value="ANT_29670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29670"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="MSVMMAT"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="42"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="354"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="598" mass="66578" checksum="34CCD6585FEB401E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N261</accession>
    <name>E8N261_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_29820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561352.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29820"/>
    <dbReference type="EnsemblBacteria" id="BAJ65008">
        <property type="protein sequence ID" value="BAJ65008"/>
        <property type="gene ID" value="ANT_29820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29820"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_6_0_0"/>
    <dbReference type="OMA" id="CAHPLDF"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="143"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="23975" checksum="DBEA3031E661FBAA" modified="2011-04-05" version="1">MLVKERMSHPVLTITPDVPVQEALARMRQDKVRRYPVVDKKGKLIGIVTDSDLMNASPSEATTLSVWEINYLLSRITVERVMTREPITVTEDTTVEEAARIMADNKIGGLPVLRDNRLVGIITETDLFKIFLEMLGARTAGVRVTVEVPDTPGKLHEITGAIYQLGGNISGMGAVLGETSETRTMTLKVTGVSLEALKTALQPLVEKIHDIREEKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N263</accession>
    <name>E8N263_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561354.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29840"/>
    <dbReference type="EnsemblBacteria" id="BAJ65010">
        <property type="protein sequence ID" value="BAJ65010"/>
        <property type="gene ID" value="ANT_29840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29840"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_1_0"/>
    <dbReference type="OMA" id="GFFLHTD"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="135" mass="15441" checksum="E4C41E3719E385F4" modified="2011-04-05" version="1">MPQHLAQIALLVRDYDEAIAFFTQKMGFVLVEDAPLTPEKRWVRVCPPGGETCLLLARAATPEQQAFVGKQGGGRVVFFLHTDDFWRDYHTMRAQGVHFLEEPRHEPYGTVAVFEDLYGNRWDLIQPLQLESPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N273</accession>
    <name>E8N273_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561364.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29940"/>
    <dbReference type="EnsemblBacteria" id="BAJ65020">
        <property type="protein sequence ID" value="BAJ65020"/>
        <property type="gene ID" value="ANT_29940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29940"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_294212_0_0_0"/>
    <dbReference type="OMA" id="FLHDEMY"/>
    <dbReference type="OrthoDB" id="152402at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_16" evidence="1">
        <location>
            <begin position="17"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1019" mass="117778" checksum="FA52BCC5385A8044" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N296</accession>
    <name>E8N296_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_30170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30170"/>
    <dbReference type="EnsemblBacteria" id="BAJ65043">
        <property type="protein sequence ID" value="BAJ65043"/>
        <property type="gene ID" value="ANT_30170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30170"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_2_1_0"/>
    <dbReference type="OMA" id="NVGLFVW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="76"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ65043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="258" mass="27994" checksum="2CAB22BE1CEE3630" modified="2011-04-05" version="1">MSLPSGSPASQPSETQPPAELGRVEPAQVRVPLTKPLVTYILLGVTVGVYLLQMLSRPLFGYDLLLAMGAKSNTLIQQGEFWRLITPMFLHVSLPHIAFNMYALYAFGVSLERHYGRRRFLLLYFIGGLGGVVLSYLLSPENSAGASTALFGVVAAEAVFLYYNRRWFGKEAVSALWNTVFIIGINLVLGLSPGIDNWGHLGGLIAGGVFAALAGPLLALRGEYPNLSLEDTRSLNRAFVVAVAEAGVLLFLVLMTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D7</accession>
    <name>E8N2D7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peripla_BP_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559137.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62743">
        <property type="protein sequence ID" value="BAJ62743"/>
        <property type="gene ID" value="ANT_07090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07090"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762162_0_0_0"/>
    <dbReference type="OrthoDB" id="1965102at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225230" description="Peripla_BP_4 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="79"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="363" mass="38497" checksum="6103C40B040EF91E" modified="2011-04-05" version="1">MKRPYYTLLAIVLALAFALSACSPQPAATAKPAPASEATPTAAQADAGSIAAADLAGEIPWAEAKEGAPFDIKGKKVCYLIPSLANTFLNGVATSVKEQAAADGVEVMVYGADDGGLTLQYNQIENCISQKVDLIYLMAAGSADSLLPAVEEAKAAGILVMGVPPAELEPFDAIMHTNQYEDGTLVAQMACDFINARYPDAEKVDVVVAGNESGEKQMWLRYQGYRTIEKCAKANVVQYLDISGDSIPVGASTAENVLAAHPNVKVFIMQSTAHAQGAAETIKALPNVDLSEYGVFAGDMDPTVIPIVTSCEDPYKGFVAIGGTNLDKNTYAIIKAMLQGVKYPRITNDELEPIHCDWSKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G4</accession>
    <name>E8N2G4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation-transporting ATPase</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_07360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62770">
        <property type="protein sequence ID" value="BAJ62770"/>
        <property type="gene ID" value="ANT_07360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07360"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_4_0"/>
    <dbReference type="OMA" id="FTIFGWF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="788" mass="85808" checksum="C15AB868AA560540" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H8</accession>
    <name>E8N2H8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559177.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62784">
        <property type="protein sequence ID" value="BAJ62784"/>
        <property type="gene ID" value="ANT_07500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07500"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_263295_0_0_0"/>
    <dbReference type="OMA" id="GHWHINA"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032879">
        <property type="entry name" value="FixG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11614">
        <property type="entry name" value="FixG_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225414" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="245"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="650"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="FixG_C" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="FixG_C" evidence="3">
        <location>
            <begin position="1180"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1278" mass="134607" checksum="EAA49FEB9F99F007" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K3</accession>
    <name>E8N2K3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07750"/>
    <dbReference type="EnsemblBacteria" id="BAJ62809">
        <property type="protein sequence ID" value="BAJ62809"/>
        <property type="gene ID" value="ANT_07750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07750"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052293_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="264" mass="29201" checksum="1A60443D3E1E9809" modified="2011-04-05" version="1">MSVGEVCPMDCGMILLYPYWRGGVNEFSFLLMIGGGLGLWRVSRQRELQWLDGAILTILCALIGARLGYVLINLAYFREVPEEILQFWLGGLSAPGALIGGLLGIGVASLLFRVSYLRMSDRLYPLLPPLAVSCWLGCWLAGCAYGAVAQPGWLGVPAPDEAGWMTWRVPVQPLAALSLIVFYALMEALIPIPRPSGWLSSLALAWLTLVNLVASLFRADPIPVWNHFRIDTWVYLGLELLFLSCFTILHFTAHRHSRGKQANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K5</accession>
    <name>E8N2K5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">nadE</name>
        <name evidence="8" type="ordered locus">ANT_07770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559204.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07770"/>
    <dbReference type="EnsemblBacteria" id="BAJ62811">
        <property type="protein sequence ID" value="BAJ62811"/>
        <property type="gene ID" value="ANT_07770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07770"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_2_0"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="276" mass="30899" checksum="C07669E6365DFF6E" modified="2011-04-05" version="1">MKTQVNLNINTDLVRRILTGFIRSEIHRMGFERAVINLSGGLDSAVSCFLAAEALGPQNVLALRLPYRTSSPESLEHAQMVIEATGVQSHTFEITPMVDPLIEHFPEMNSLRKGNIMARMRMIVLYDQTVAFNGLAVGTGNKTEILLGYTTLYGDSACALNPIGDLYKTQVRQLARALGVPQVVIDKPPSADLWAGQTDEGELGFTYAEVDKLLYLLIDERYTPQECIEAGFDSRFVHAVVERVRKNQFKRMLPPIAKLSNRTIGYDFLYLRDWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T8</accession>
    <name>E8N2T8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">serC</name>
        <name evidence="9" type="ordered locus">ANT_30620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6 7">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6 7">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561429.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30620"/>
    <dbReference type="EnsemblBacteria" id="BAJ65088">
        <property type="protein sequence ID" value="BAJ65088"/>
        <property type="gene ID" value="ANT_30620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30620"/>
    <dbReference type="eggNOG" id="COG1932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034866_0_2_0"/>
    <dbReference type="OMA" id="GYRASMY"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00611">
        <property type="entry name" value="PSAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="8"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ65088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="365" mass="40364" checksum="4E7F8EE2F13D7A5B" modified="2011-04-05" version="1">MSTYKRVHNFNAGPSILPEPVLLQAQAEMLDYQGTGMSVMEMSHRSKEFEAIIQTAEADLRELLGIPQNYKVMFLQGGASLQFAMLAMNLRPAGASADYIVTGAWSRTALKEAQKLGTTRVVFNGEGENFTRLPEPAELQFDPNAAYVHFCHNETIHGVEFKSEPVVPEGVPLVCDMSSDFLSQPVDVSKYGLIYAGAQKNAGPAGVTIVIIREDLLARVPEKMPVMLDYKVLAESGSLHNTPPCYAIYITGLVLKWLKNLGGLNAMYEINREKSEMVYRAIDESGGYYRGHARPEARSIMNIPFRMASEELEDLFVKEAKKADLIGLKGHRSVGGLRASLYNALPVASARALVEFMKDFQQRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N305</accession>
    <name>E8N305_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M23 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561496.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31290"/>
    <dbReference type="EnsemblBacteria" id="BAJ65155">
        <property type="protein sequence ID" value="BAJ65155"/>
        <property type="gene ID" value="ANT_31290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31290"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4991">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378858_0_0_0"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="417"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="494"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="655"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="731" mass="79109" checksum="4BBC0B4A7F39BAD9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N308</accession>
    <name>E8N308_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_31320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561499.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31320"/>
    <dbReference type="EnsemblBacteria" id="BAJ65158">
        <property type="protein sequence ID" value="BAJ65158"/>
        <property type="gene ID" value="ANT_31320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31320"/>
    <dbReference type="eggNOG" id="COG4132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_18_6_0"/>
    <dbReference type="OMA" id="LKREWRE"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="311" mass="33810" checksum="DC5E3E72FA7A830B" modified="2011-04-05" version="1">MSPALLRQSGNEGGLGLRPASPSSPPRAPKQSGLWAWAGVAPFFLFALLFMLLPSLSLLVGSFRDAQGNFTLENIRSLFTPSILSAYSISIRISLVTALGGALFGFLLAYAVILGGLPRWARDALLTFSGVASNFAGVPLAFAFVATLGRLGMLTVFLKAIGIDLYEAGFNLYSFWGLSFTYMYFQFPLMVLIIAPALEGLKREWREAAENLGATAWQYWRMVALPILTPSILGAIILLFGNAFGAYATALSLTGGLINLITILIGAQMMGDVLYNPGLGYALSFGMIVVMALNMVVYYFLRKRSERWLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N328</accession>
    <name>E8N328_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561518.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31540"/>
    <dbReference type="EnsemblBacteria" id="BAJ65178">
        <property type="protein sequence ID" value="BAJ65178"/>
        <property type="gene ID" value="ANT_31540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31540"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OMA" id="VDLWQVH"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="333" mass="38024" checksum="1D73CC7885D33B6C" modified="2011-04-05" version="1">MEYRFLGRSGMKVSELCLGAMTFGRETPEEESYPILDRFAEVGGNFIDTANVYSRGISEEIVGKWLKGKRREDWVIATKVRFPMGEGVNEVGLSRKHILAAVEDSLRRLQTDYIDLYQVHAWDSATPLEETLSTLNRLVEQGKVRYIGASNYSGWQLQKAIDVSLMNGWEAFVSLQPLYNLLDRELEWELVPVCQNEGLAILPWSPLRGGWLSGKYHRGMQAPPEGSRVDEASRQNWSERWEKYNTEHTWSVLDALYAIAQRLGKHPAQVALRWLLQKPGVTAPIIGVRSLEHLETNLGATGWQLSDEEMAELDRVSEKEPPYPYWVSNTPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N349</accession>
    <name>E8N349_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_31750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561539.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31750"/>
    <dbReference type="EnsemblBacteria" id="BAJ65199">
        <property type="protein sequence ID" value="BAJ65199"/>
        <property type="gene ID" value="ANT_31750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31750"/>
    <dbReference type="HOGENOM" id="CLU_820497_0_0_0"/>
    <dbReference type="OrthoDB" id="1951097at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="38688" checksum="264473701A770FD7" modified="2011-04-05" version="1">MRITRETLLRIARSAADERARVSRRIRCIYLTGSLMEEEPLLGGTADVDLVIIYDTEPNVPREIVPVTDEVHLDIAHFAQETFRQPRHLRTDPWLGPFIYAKPLVLFDPQHWFDYIQAATGAQFWQADYTLARARAFAEQARRAWMNLTLQSDPSHARRLCAYLKVIENAGNALVSLRALPLAERRFLAQLEQHLQQAGWGDLYRQMVALLSEEIEVNDEQWQTWMSAAAQAWDQSARQEALPPRLHPARRAYYLKALSALWENAPSAAYWLLLRVWTLAAAHLPAGAPELQPWQDMTQQVGLDKARFAARLEQMDAFLDQVEETLDRWGEAHGASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N392</accession>
    <name>E8N392_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_08720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559298.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08720"/>
    <dbReference type="EnsemblBacteria" id="BAJ62906">
        <property type="protein sequence ID" value="BAJ62906"/>
        <property type="gene ID" value="ANT_08720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08720"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507631_0_0_0"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="178" mass="19212" checksum="314874CB4D15F29B" modified="2011-04-05" version="1">MRLRLWLICFFVAWGLAFLAIPVNAEDLQQGIITATPQPDGSIVHVVQEGETLATIAEAYGVSMAEIRALNGLAPTANLIFPGERLIIRIAPTPTETPTITPTVPRPTRTPTPVTPTRTPVPTRTPAPTLTPTPTPHPVVQAVNGFVEANRRPLLIGMVVTCAVGLIWTLWAGFRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N397</accession>
    <name>E8N397_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_08770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559303.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08770"/>
    <dbReference type="EnsemblBacteria" id="BAJ62911">
        <property type="protein sequence ID" value="BAJ62911"/>
        <property type="gene ID" value="ANT_08770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08770"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="OMA" id="GIMNITF"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="311"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="410" mass="43420" checksum="9B35A899765AD18B" modified="2011-04-05" version="1">MNILQAVKEALESLSANKLRSGLTMLGIIIGVAAVIAMISLGRGVEASVNDQLAGVGSTLITLFAMPDREVRNPQPLTLSDAEALMDAAHFPEVQAVAAEINLNASVSFGTVNTATSILGVTANYKDVQNLHLNEGDFIHEEQVLGQSAVAVLGARAAKTLFEREAGIVGETIRIDGQPYRVIGVLRSRGSGGLSFTQTDNAVLIPITTAKLRLAPERVRGEVDLITVQVRSASQIKAVSERITETLRIRHNIPVGLSDVTVFVQKDVLDALNQITSILTVFLGGIAAISLLVGGIGIMNIMLVSVSERTREIGLRKAVGARRRDILMQFLTESVLLSLVGGMLGILTGWMIGAVIQLISTQSGSPIRFALNVDAILLATITSSAIGIFFGLYPANRAAGLTPVEALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C5</accession>
    <name>E8N3C5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-dicarboxylate transporter/malic acid transport family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_09050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559331.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09050"/>
    <dbReference type="EnsemblBacteria" id="BAJ62939">
        <property type="protein sequence ID" value="BAJ62939"/>
        <property type="gene ID" value="ANT_09050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09050"/>
    <dbReference type="eggNOG" id="COG1275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_6_4_0"/>
    <dbReference type="OMA" id="PVQSMFI"/>
    <dbReference type="OrthoDB" id="1600064at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="363" mass="39123" checksum="0453F3B5C73ED364" modified="2011-04-05" version="1">MSVQSSRQEILRTFHPGWFGAVMGTAILATILSLNPAGLVALKPVLQAAAVGFHLFALILLIGLLIPTVYRWIVYPQESLQDLKHPIFGAMFATLPAGFLVLASATASAGKLWLPPSVSTSLLIILSGIGTVLGFAFSVAFTYFLFLNPEVRKDQANGAWFIPPVTNIIIPLALLSLIPLAPESFQNPLYALSIAFWGAGFFLFLMVAAILYERLIFHSLPPAGMIPSLWIGLGPLGVGGLVLLRLAQAGTSFLGEAMTIFLPLASVAALALWGLGIWWLGVVLPITLRAEKHGGIPYNPGWWGYIFPGGAFTALTLSLARTLQSAFFETLGALFALGLLLLWIRVFWNTLKAIQKGTAWKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C9</accession>
    <name>E8N3C9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559335.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62943">
        <property type="protein sequence ID" value="BAJ62943"/>
        <property type="gene ID" value="ANT_09090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09090"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033160_3_1_0"/>
    <dbReference type="OMA" id="FENFAYL"/>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017746">
        <property type="entry name" value="Cellulose_synthase_operon_BcsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06564">
        <property type="entry name" value="CBP_BcsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="407" mass="45417" checksum="58B5737CB99A1B55" modified="2011-04-05" version="1">MPEKILVVDDDALMRLMVTKTLSTEGFEFLEAENGVQAVEKAIAHQPDLIIMDVNMPEMDGYEACQRIRSNPITSAIPIILVTSLSTVEDKIKGFDSGADDYIPKPFDPIELTMRVNVLLRRMARIKATVKAPEVRPGKVIAFFSLRGGIGTTTLATNTAIALTRLWGTPTALVDLVLACGQCALMMNIPPRNSWADLARIPNEEIDIEVLRNVLRPHESGVLVLVAPNHPEEGEMIDGPKVSHVLDLLKKEYPYIILDLPHEFCEKTLAGLDTADEIWLLLAPELASVRATLLAMETFQMLNYPLERVKLLLNWTFERRGLARKAIEKTLKREIDVVIPYASEPLVKSINLGVPAVLDDTNPPLVALFENFAYLLSREDHKNNPPVNPTPTYQRVMEYLAEKNSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3D7</accession>
    <name>E8N3D7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_09170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62951">
        <property type="protein sequence ID" value="BAJ62951"/>
        <property type="gene ID" value="ANT_09170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09170"/>
    <dbReference type="eggNOG" id="COG1956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278075_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="447"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="498"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="5">
        <location>
            <begin position="955"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1138" mass="129356" checksum="F5C846A4DEEFADA9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M9</accession>
    <name>E8N3M9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 9">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rplV</name>
        <name evidence="10" type="ordered locus">ANT_10090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6 9">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559434.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10090"/>
    <dbReference type="EnsemblBacteria" id="BAJ63043">
        <property type="protein sequence ID" value="BAJ63043"/>
        <property type="gene ID" value="ANT_10090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10090"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_1_0"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="113" mass="12853" checksum="AC3E33DA798ADAE2" modified="2011-04-05" version="1">MATDIRAQLKFAETSAQKARLVVDLVRGKPVVEASNILRFTPKKAARIINKVLDSAIANAEENFGVSRDNLYIHEIAADEGPTRKWRRFGARGRFKPILRRTSHITIVLRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3T5</accession>
    <name>E8N3T5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559489.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63099">
        <property type="protein sequence ID" value="BAJ63099"/>
        <property type="gene ID" value="ANT_10650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10650"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_4_3_0"/>
    <dbReference type="OMA" id="WELLHHI"/>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="192" mass="22134" checksum="6C7DF5D5FBD8AF52" modified="2011-04-05" version="1">MLWLERVTRWLAFNLWYLKQPPWDTGISPPELVAFIQSHPSGRALDLGCGSGTNLLTLAKAGWQVVGIDLSLLAVWRARQRLRRENMKGQVLNGSVTNLSHVSPPFDLILDIGCYHGLPQEDRVRYRQNLLNYLAPSGTFLLYAHLKQEGQNQMPGISREEMETFNALLTPVHIQESRDRWERVVVWLEYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V4</accession>
    <name>E8N3V4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_10840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559508.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63118">
        <property type="protein sequence ID" value="BAJ63118"/>
        <property type="gene ID" value="ANT_10840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10840"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046840_2_0_0"/>
    <dbReference type="OMA" id="SSCHTFQ"/>
    <dbReference type="OrthoDB" id="414486at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="444" mass="50605" checksum="446708BAF0DC80E3" modified="2011-04-05" version="1">MCDTFVVLSEKTGGRGTLLGKNSDREPNEAHQVVFIPAQDYPEGASVRCTYREIPQVRHTFAVLLMKPFWIWGAEMGVNEHGVAIGNEAVFTRMPYLKDAQLTGMDLLRLALERAVSAEGALNVIVELLEQYGQGGNCGLTHGFYYHNSFLIADPREAWVLETAGTHWVAEKVKGIRTISNALTIGETWDRISPQAIAFARQQGWVPKGKDFSFSRAYSDFLYTTFGAGRFRQSCTTRLLLESQHPVQLFQAFRVLRVHGQGEDEPNWRPDVAVHGADVCMHAGWGPVRGSQTAGSAVFELREDGVRVWVTATAAPCTSIFKPLYLDTPIPWQSEPTPTAFFDPACLWWRHERLHRKTLENYPQRIALYRAERDALEARFLQDLPDEQASLDERMRYVQTCFSMAEQAEERWLKAVRSEGEEHRRFYTRWAWSKFNQQAKMPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V8</accession>
    <name>E8N3V8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559512.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63122">
        <property type="protein sequence ID" value="BAJ63122"/>
        <property type="gene ID" value="ANT_10880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10880"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_716968_0_0_0"/>
    <dbReference type="OrthoDB" id="798498at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="266"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="385" mass="44349" checksum="52F9F3505724F9C2" modified="2011-04-05" version="1">MNLRGKGFYLWNIPNCEKGNVQAIAEEAQKAGLTHVLIKIADRFYPHNMSKDGKEDYVPPLVEALHARGIQAWGWQYIYGFEPIPEAQIAIRRLSQLHLDGFVIDAEEQYKLPGRKIAAQKYLGELRSHFPDLTLGFSSYRFPKLHASLPWEVFLSQVQVIMPQVYWEQAHNPAAQLHRCLMEYRNLQPAAPIIPTGAAYKWGGWRPTPQDIQEFLQAVEENELPGCNFWGWEFCRRDLPELWEVIAHHHRAPAPQPAPPSKDIIEALFEALNQQDIHRLLLLYHPAAVHVKALRTDQGHPAIERWYRYFLNDLLPQARYTLTSLHSQGNLRFFKWKASSPRGEVQEGTDTVHLFNDRILYHASNFQITHPTVSVAVESQALHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N455</accession>
    <name>E8N455_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559607.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63219">
        <property type="protein sequence ID" value="BAJ63219"/>
        <property type="gene ID" value="ANT_11850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11850"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_0"/>
    <dbReference type="OMA" id="HVTPHEI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="123" mass="14044" checksum="6AF0FFFE807DDE26" modified="2011-04-05" version="1">MAGEKHILYVEDNPDNRMLVRRLLTAFGYEVIEAENATRAMEILKTTKPVLILMDINMPDVDGYTLTNRIKSDPELFNIPVIALTANVMKGDRERTLDAGCDGYIEKPIDVDRFIEQIERFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N463</accession>
    <name>E8N463_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ordered locus">ANT_11930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559615.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11930"/>
    <dbReference type="EnsemblBacteria" id="BAJ63227">
        <property type="protein sequence ID" value="BAJ63227"/>
        <property type="gene ID" value="ANT_11930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11930"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_1_0"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="188"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="403" mass="42550" checksum="AD7CA9193E4D9AFB" modified="2011-04-05" version="1">MSNPIAGKSITLGVTGSIAAYKAADLASKLHQSGAQVDVILTDAALKFITPLTFQSVTARKAYTDADLWGGEGHVTHVAIGHAADLVIVAPASANTIAKLAYGIADNLLTVTVLASTCPLLIAPAMDAGMFSNPATQKNLEILRERGAVIVGPAEGHLASGLVGKGRMVEPLEILGEVRYLLSRKGPLAGKHVVVTAGGTQEPIDPVRFITNRSSGKQGYAVAQAALDMGADVTLITTPTALNAPCGATVIHVRTAEEMLHAVLTYSRSADLLVMSAAVADFRPAQSAEQKIKKTGKELALTLMPTRDILATVKEKRQQSGFPRHVIGFAAETEDLLNNAQKKLETKGLDMIVANNVSATDAGFEVETNRVSFLFADGRKIDLPLQSKYAVAERILEEALSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N471</accession>
    <name>E8N471_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="synonym">gcp</name>
        <name evidence="8" type="ordered locus">ANT_12010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63235">
        <property type="protein sequence ID" value="BAJ63235"/>
        <property type="gene ID" value="ANT_12010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12010"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_0"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="36"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="347" mass="37787" checksum="17168C9C8C7F8A00" modified="2011-04-05" version="1">MEKRKDLSKQPIRVLGIETSCDETAAAVVEDGRIPLSNVVASQVELHKKYGGVFPEVASRQHIRTIYAVVDEALQKSHLSLRDLDAVAVTRGPGLAGSLVVGMNTAKGIALAGNLPLIGVNHLEGHLYAAWVRRDEHDDHPEPQFPLVALLVSGGHTELILITDHLQYKRLGGTLDDAAGEAFDKVARLLGLPYPGGPAIQNAALRGNPDAFSFPRARLDGTWNFSFSGLKTAVLRVVREFEEKQQSLPVEDLAASFQAAVVDVLFAKTLQAARMFKAREILLAGGVSANLALRAAFTGQNEFRVHIPDLSLCTDNAVMIAAAGYYRWLHEQRDPLDLDVLPTWQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N485</accession>
    <name>E8N485_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_12150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559637.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63249">
        <property type="protein sequence ID" value="BAJ63249"/>
        <property type="gene ID" value="ANT_12150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12150"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_0"/>
    <dbReference type="OMA" id="PAYAPWF"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228168" evidence="2">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="59"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="59"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="291" mass="31821" checksum="75B3E54E83B57E4A" modified="2011-04-05" version="1">MKRLSIWMFLVLVFGLVLSACAPSSGSSAGETSQESQGNAQTGCLGSADTALVDLQCRKITVAVENAYMPFNYILVATGEPGGWDYDALREICTRLHCEPVFVEAAWDGMIQAVADKQYDMAADGITITEDRKQIVDFSIGYISINQRLLVRKGETRFASIEEFAANEALVLGTQINTTNYETAKKYLPESRIKGFEQFAFAVQALISGDVDAVIIDETAGQGYRGENAEKLELIGPSISSDELGFIFPKGSDLVEPFNKAIEAMKADGTLDRLNQKYFGPDFKLTESDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N497</accession>
    <name>E8N497_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pre-crRNA processing endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559649.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12270"/>
    <dbReference type="EnsemblBacteria" id="BAJ63261">
        <property type="protein sequence ID" value="BAJ63261"/>
        <property type="gene ID" value="ANT_12270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12270"/>
    <dbReference type="eggNOG" id="ENOG502Z82V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086014_0_0_0"/>
    <dbReference type="OMA" id="YLGCREF"/>
    <dbReference type="OrthoDB" id="1619114at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010155">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029950">
        <property type="entry name" value="Cas_CT1134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01876">
        <property type="entry name" value="cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="223" mass="26109" checksum="2A9097CCC4AB80AC" modified="2011-04-05" version="1">MGYGIIIRVKGDYALFTRPEMKVERVSYDVITPSAARGIIEAIYWKPAIRWVIDKIHVLREIEFTNIRRNEVSSKVSVDNTLQVMRGANKPLYISVTDNRQQRASMVLKNVDYVIEAHFERVEKEWGERDTEEGHYNIILRRLRKGQFFHAPCLGTREFPAIVEVIEDKHDIPPSPLKGKRDLGWMLYDLDFSNPRDIQPMFYHAVMEDGVIHVQELAQEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A1</accession>
    <name>E8N4A1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63265">
        <property type="protein sequence ID" value="BAJ63265"/>
        <property type="gene ID" value="ANT_12310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12310"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_4_4_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="90" mass="10853" checksum="5FF50335773914CD" modified="2011-04-05" version="1">MWIMRTGAQWKDMPERYPPYQTCHRRFQKWARLGAFEEMLKALVQDMKERGDLDLTECFIDGTFVIAKKGQRYKDHGSGRPLWSSYRHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G3</accession>
    <name>E8N4G3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_12930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559715.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12930"/>
    <dbReference type="EnsemblBacteria" id="BAJ63327">
        <property type="protein sequence ID" value="BAJ63327"/>
        <property type="gene ID" value="ANT_12930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12930"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054045_0_0_0"/>
    <dbReference type="OMA" id="FNWVADV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="331" mass="36009" checksum="3D16C555BB149C60" modified="2011-04-05" version="1">MKKFLIALVLLLGILFIIGRAAEMQDIGKVLQRGDFGWIALAIVLLGGWFFNLGLTYQAIYAILDMPVSALHMTRVATAVNFINIVAPSAGLGSVAIFMSDAASNNRSTGKTAIAAVMFVLLEYVAVLFVLVFGLAELAYRNNLHWAEVIASLILLIGALGLAILLYIGMQSASLFARVLQWGARTVNRLLKPFIKKEYLSEERAHEFAFEAAEGIAIVRHHPQRIIRPILLALLNKVILIGILTLTFLAFHVPFTPGVVIAGFSLASLFLIVSPTPAGIGIVEGVLTVALRSLQVPIEDAAVITMAYRGITFWVPLLVGMVTFRTLPHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L2</accession>
    <name>E8N4L2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_13440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559763.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13440"/>
    <dbReference type="EnsemblBacteria" id="BAJ63376">
        <property type="protein sequence ID" value="BAJ63376"/>
        <property type="gene ID" value="ANT_13440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13440"/>
    <dbReference type="eggNOG" id="COG4638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039484_1_1_0"/>
    <dbReference type="OMA" id="ENLMDMY"/>
    <dbReference type="OrthoDB" id="691776at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044043">
        <property type="entry name" value="VanA_C_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19112">
        <property type="entry name" value="VanA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="327" mass="37806" checksum="1D6971A4A8236B5E" modified="2011-04-05" version="1">MIPNQWYVVLESREVRVGRPVGAVRMGEKMVFWRRKDGKVVCMADRCPHLGASLSRGKVVEDHLACPFHAFEFDPGGACVYIPALGRNTPPPKAMRIKSYPTYEAHGFIWIYWGEPQGELLPPKFFDIDETFSYAGYRQLWPVHYSRMVENQLDVMHLPHVHTDTIGRGRKVVVDGPLARVEDGVLKVWVFNRKDDGTPPRRADELPTPSRPPFLEFIFPNLWQNRISSDYRIVVAFVPVDEEHGMFYLRQYQRIVRIPILREIVNWIGVLGSHHIAEQDRRVVSTQLPKKSALRGEDKPVQGDHAILTYRRYREELIEKARSNGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U0</accession>
    <name>E8N4U0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="2 7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pdhA</name>
        <name evidence="9" type="ordered locus">ANT_14260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559836.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14260"/>
    <dbReference type="EnsemblBacteria" id="BAJ63454">
        <property type="protein sequence ID" value="BAJ63454"/>
        <property type="gene ID" value="ANT_14260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14260"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_0_0"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="8">
        <location>
            <begin position="12"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="35628" checksum="CBE69D17483FC6F6" modified="2011-04-05" version="1">MEKDEYFRMYREMVVIRRLEERSAELYQQGKIGGFLHLYIGQEAVSTGLISARKPQDRVITAYRDHGVAINCGLSAREVMAELLGKATGCSKGKGGSMHLADVTKNFWGGHAIVGAHLPIATGLALGDAYKGEKNVTICMFGDGATNIGFFHEALNMSKIWNLPVLWVCENNQYGMGTAVERASAVSEIIQKAQAYAMPSRRVDGMDVMAMRQAAEEMIEAIRNGAGPMLMEAMTYRFRGHSMGDPERYRKPEEVHRYQENDPIGIFRKYLQENGIATEEELNQLDDEAEAIVEDAVQFAEASPEPQPHELFEHIYVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z9</accession>
    <name>E8N4Z9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559895.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63513">
        <property type="protein sequence ID" value="BAJ63513"/>
        <property type="gene ID" value="ANT_14850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14850"/>
    <dbReference type="eggNOG" id="COG2055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_3_0_0"/>
    <dbReference type="OMA" id="TNTEPAM"/>
    <dbReference type="OrthoDB" id="1374098at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="360" mass="39108" checksum="D762CE31FF681616" modified="2011-04-05" version="1">MSRLVYRVEDLRNYVIRFFLKHDVPLEDAEIVADVLISADLRGVDSHGVIRLDSYYGSRLRKGLIDPHSQLKVLTETPSTLALDGGTGLGHVVGYKAMQMCIEKARQVGVGMVTVRNSNHYGIAGYYAMMALEHDMIGISFTNSQPLVAPTYGKTRYLGTNPIAVAVPAGKERPYVLDMATSIVPIGRITVYQKAGKKIPEGWGVDKDGNVTTDPGAVLNGGALMPLGGIDLMRGYKGYGLALWVDIFAGVLAGAATGPEVGKSDRPANVGHYFAAIRVDAFRPVDEFKAEMDALIQGLKNAPKAEGQDRIYIHGEKEFELAEKYQKEGIPLMKEVVDSLIASGKEVGVPFDLTPIREID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N500</accession>
    <name>E8N500_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63514">
        <property type="protein sequence ID" value="BAJ63514"/>
        <property type="gene ID" value="ANT_14860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14860"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_0"/>
    <dbReference type="OMA" id="MRLNFTY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="422" mass="47285" checksum="07F821A179CA1D43" modified="2011-04-05" version="1">MYSPRFILQGGKRMVTPWEHRFAQRTQRMKSSAIRELLKLTEDPEVISFAGGLPAPEVFPVEEILEAATKVLREQGSRALQYGSTEGYTPLREMIARHTSRYGIDVTADNILITSGSQQALDLLGKVFINHGDRILVEAPTYLGALQAWDIYGAEYVPVRSDNDGIVTDELEGALRTGPKFIYVLPNFQNPTGVTISYERRLKLVELADHYGVPIIEDDPYGQLRFEGEHIPPIEVLDSQKHHNGSCYTGNVIYLSTFSKILAPGLRLAWVVAPPEVIRKLVMAKQGADLHTATFNQMVAYEVGRGGFIDRHVELIRKVYRERRDVMLKALEENMPEGVEWTHPQGGLFLWVRLPEGMDTAELFKIAVSQKVAFVPGAPFFPKGGGENTMRLNFSNATPEKIEEGIARLAKAIKEMLVKQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N507</accession>
    <name>E8N507_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lycopene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559903.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14930"/>
    <dbReference type="EnsemblBacteria" id="BAJ63521">
        <property type="protein sequence ID" value="BAJ63521"/>
        <property type="gene ID" value="ANT_14930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14930"/>
    <dbReference type="eggNOG" id="COG0654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042644_0_0_0"/>
    <dbReference type="OMA" id="LQHFRGW"/>
    <dbReference type="OrthoDB" id="1597893at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="385" mass="45482" checksum="B95F35E79690ACCB" modified="2011-04-05" version="1">MKKYTFIILGAGAAGLSLAYYLVHSKLRDQSILLIDREEKNRNDRTWCFWSSRDEVFSSIFYRSWEKIGFIHEEWQKVIPLGEYRYNMIRGIDFYQEVRQTLRARLNVDWITAPVTQIIDTPEFALVAAGGKTYQAEWVFDSRFDPNLIEKKPERYHYLLQHFLGWEIETLQPTWDSSIPILFDFRVSQETGFQFFYTLPFNENRALVEYTFFTPTLLSDEEYQRGLETYLKNVLRLDTYEIHDVEKGVIPMTDHPLPRRGGRRVMNIGTRGGRVKPSSGYAFARILRDSREIVRSLEKYGTPFRVPASPRRYAWYDRLLLQILYRQPQTGKAIFTALFKNNPPQRIFRFLDEEGSLLENIRLIASLPPVPFLKALLQVNFLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N520</accession>
    <name>E8N520_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sec-independent translocation TatB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_15060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559916.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63534">
        <property type="protein sequence ID" value="BAJ63534"/>
        <property type="gene ID" value="ANT_15060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15060"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1657188_0_0_0"/>
    <dbReference type="OrthoDB" id="2204869at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="159" mass="17900" checksum="96211F31F5D96CA0" modified="2011-04-05" version="1">MQILNIGPLELIIIFLVMFILLGPEGMIKTARQIGLWIRKVVQSPIWREIMGYSQEIRELPTKIVRETGLEEDLEEIRKSTQLTAEEVENTVKEVNREINETVKEAGKVEVNLDLNPPAKSVPLNASTSSTHGKDGTSLPVPPVQTYDKYAQSSDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N540</accession>
    <name>E8N540_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559936.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15260"/>
    <dbReference type="EnsemblBacteria" id="BAJ63554">
        <property type="protein sequence ID" value="BAJ63554"/>
        <property type="gene ID" value="ANT_15260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15260"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985693_0_0_0"/>
    <dbReference type="OMA" id="CSHILAI"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="31400" checksum="F2EB52F85C25F370" modified="2011-04-05" version="1">MDKVCILTDAASQFTHPGFPGYQYVWIIPFDISLRGLLYPEGEGIRWNYLPPSTLNGIKPCLKSPDAETLYTLFQKHAKECSHILAIFSSSELVPIYKAAEEAAQAAKNLVPITLIDSQTISVGVGLLVQMAAQEVANGQDPWSIEQKIRKTIPKLYTLICTAGLSYLHEAGFLEKPQAIAGEMLNMLPVLSFEEGKITPIEKAKNVRAALDFFQEFLEEFEDLKHIAVIQGVSPFNHETQVLRNYVHEIYPDVPFSEHSLNLPTAILFGPRTLGMVILEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N542</accession>
    <name>E8N542_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ordered locus">ANT_15280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559938.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15280"/>
    <dbReference type="EnsemblBacteria" id="BAJ63556">
        <property type="protein sequence ID" value="BAJ63556"/>
        <property type="gene ID" value="ANT_15280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15280"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_0"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="19357" checksum="FB356D1413BB30BB" modified="2011-04-05" version="1">MVRAFFPGTFDPIHYGHMNIALRASNLFDELIVAVYDRPLKNLLFSPEERMELVKQAFFGQEKIRVIGYRGLTVDACRENGAQVIVRGLRVFSDFEYEFRMALANHRLAPDIEVIALITNEEHTFLSSSTVREIAALGGDISSMVPPHVEIALKDKLKQTPSLQLPMPVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N554</accession>
    <name>E8N554_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63568">
        <property type="protein sequence ID" value="BAJ63568"/>
        <property type="gene ID" value="ANT_15400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15400"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_0"/>
    <dbReference type="OMA" id="CGTWAWG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="316" mass="35829" checksum="7CF5CCA1FC7BD99F" modified="2011-04-05" version="1">MVRRGKMNQRLGKDIFENHLMGIGAWAWGDRFVWGYGKGYSLADLREVFEISIRSGITFFDTAEVYGQGESENILGQFLETAQQKVFIATKFMPFPWRLSRQALINALKGSLRRLRLQQVDLYQIHQPLPPVNIETWMEGLIEAVQQGMTRAVGVSNYDVDQMQRAYDRLIKDGINLASNQVEYHLLNRKIERNGLLQRANELGVKIIAYSPLAMGVLTGKYSPESPPSGIRGARYNSRVLRKIQPLINLLRDIGEAHHKTPAQVALNWVICKGALPIPGAKTRGQAEQNAGALHWKLSEEEMLMLDEMSERVVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N555</accession>
    <name>E8N555_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3'-5' exonuclease DinG</fullName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dinG</name>
        <name evidence="9" type="ordered locus">ANT_15410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5' exonuclease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the helicase family. DinG subfamily. Type 2 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63569">
        <property type="protein sequence ID" value="BAJ63569"/>
        <property type="gene ID" value="ANT_15410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15410"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012117_1_0_0"/>
    <dbReference type="OMA" id="VVTNHAM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02206">
        <property type="entry name" value="DinG_exonucl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006310">
        <property type="entry name" value="DinG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01407">
        <property type="entry name" value="dinG_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="250"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="272"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="748"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box" evidence="5">
        <location>
            <begin position="467"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="285"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="934" mass="104984" checksum="4BFC6052B5525ADB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N591</accession>
    <name>E8N591_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63605">
        <property type="protein sequence ID" value="BAJ63605"/>
        <property type="gene ID" value="ANT_15770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15770"/>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718953_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="30"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="384" mass="42633" checksum="1E267F0BF4D90A05" modified="2011-04-05" version="1">MEVVMGHLDEYMQDLKRVLEKIPLEKVEEVIRLLQNARMNEKQVFILGNGGSASTASHMVCDLAKNTRKRGFPHFRVFGLTDNMAIMTAYANDEGYETVFANQLENWVEAGDLVIAISASGNSPNVLKAVELANQRRAITVGFTGMTGGKLIHLAQVVIHVPSMRIEQVEDVHLMLEHMICSAIKEMEVPVHAGEVLSPGPLDKAEQLFGFPVASDEQLQSDKSELLEAITREFSEKLDLHEFLPKILDFTVQSVGATSGSIVVLDENGEVIEGAITYAGEVLRKPSNTLSRATQEGLANWVIENRQPALVENTMRDPRWMQSEPQKVQTDVARSAICVPLMVQDRVAGVLTLSRPSPYHFTMEDLAMLTTITVAISYSFRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N594</accession>
    <name>E8N594_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559988.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15820"/>
    <dbReference type="EnsemblBacteria" id="BAJ63608">
        <property type="protein sequence ID" value="BAJ63608"/>
        <property type="gene ID" value="ANT_15820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15820"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_7_0_0"/>
    <dbReference type="OMA" id="HSGIYAN"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="28868" checksum="0016EAC10E6CE26A" modified="2011-04-05" version="1">MVTDQRVLTAEKPEPLTHGSHGVRLYLQRQADTLPRYLLEQLMYAMFGWIPTIIGIGIRAIMYRIILSIKGWAAIENHVRLRFANRIKLHHGVYLDQGVYLHACPNGIEIGENSIVMHGAVLHVYNFRNLPHAGIRIGKDCLIGEYSVIRGQGGVWLGDRVYTSPFTQILAVNHVFRNPEEPFIYQGITAEGIIIEDDVWLGAGCIITDGVKIGKGSVVAAGSVVTHDVPAHTLVGGVPAKIIREITEENFPVNGRKVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E9</accession>
    <name>E8N5E9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_16370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16370"/>
    <dbReference type="EnsemblBacteria" id="BAJ63663">
        <property type="protein sequence ID" value="BAJ63663"/>
        <property type="gene ID" value="ANT_16370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16370"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096461_0_0_0"/>
    <dbReference type="OMA" id="HWINRVD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="236" mass="27124" checksum="A00418DE66E189B6" modified="2011-04-05" version="1">MRLYFIRHAQSENNALYERTGSENGRSDDARLSELGKVQAQHLAEFIMNGFDPTEKSNGKGFAFTHIYCSPMYRAIATGTYISQALGQPLKVWKDWHECGGMYLTNPITGKKEPRPGITLTQVREWFPELLTEGYIKEDGWWNRPFEEDGERDVRARRVLKELLSRHGGTDDCVAVVSHAGFYVHFLTAVMGLESLRPLWFRMHNAGISRFDFETENTVLVFHNFVSYLPPDLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5F6</accession>
    <name>E8N5F6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="9">1.2.7.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_16440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16440"/>
    <dbReference type="EnsemblBacteria" id="BAJ63670">
        <property type="protein sequence ID" value="BAJ63670"/>
        <property type="gene ID" value="ANT_16440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16440"/>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_0"/>
    <dbReference type="OMA" id="KLPWNDI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="698" mass="79351" checksum="C1CBD3FFD1B38DE4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J2</accession>
    <name>E8N5J2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable glycine dehydrogenase (decarboxylating) subunit 2</fullName>
            <ecNumber evidence="4">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glycine cleavage system P-protein subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine decarboxylase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine dehydrogenase (aminomethyl-transferring) subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">gcvPB</name>
        <name evidence="5" type="ordered locus">ANT_16800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvP family. C-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560085.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16800"/>
    <dbReference type="EnsemblBacteria" id="BAJ63706">
        <property type="protein sequence ID" value="BAJ63706"/>
        <property type="gene ID" value="ANT_16800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16800"/>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_0"/>
    <dbReference type="OMA" id="MHINLHK"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00713">
        <property type="entry name" value="GcvPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023012">
        <property type="entry name" value="GcvPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="488" mass="54094" checksum="E3253B880C358E3C" modified="2011-04-05" version="1">MSEPTIFELSSPGRTGVTFPQADVPSTPLPDTLIRENLPLPELSEVDVVRHFTRLSRMNYCIDYGIYPLGSCTMKYNPRINEATARFPGFAYTHPLQPEETIQGNLYLMYHLQEWLKEIAGFSAVSLQPAAGAHGELTGILMIRAYHQHRGDTKRTRVLIPDSAHGTNPATSAMSGFEVVPVPTDKNGNVDLEILRSLLDDTIAGIMLTNPNTLGLFEQNILEVTKLVHQVGGLVYGDGANLNALLGIARPGDLGIDVMHFNLHKTFSTPHGGGGPGAGPVGASERLKDFLPGPIVEIVEEGNEDYPPLYGFREPKYSIGRVKSFYGHFGIMIRAYTYIAMHGPEGLRKVAENAVINANYLQARLRGTYKIPYDRICMHEFVVEGKWADAPEIIALDISKRLMDYDFHPPTNYFPLIVHDALMIEPTETESKQTLDAFADALIKIAEEAHTQPELLKSAPHNTPVRRVDEVKAAKDLVLCCWLPEEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R0</accession>
    <name>E8N5R0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine (Thiol)-lyase</fullName>
            <ecNumber evidence="5">2.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_17480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560152.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63774">
        <property type="protein sequence ID" value="BAJ63774"/>
        <property type="gene ID" value="ANT_17480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17480"/>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_0"/>
    <dbReference type="OMA" id="TYTLFAH"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="431" mass="47619" checksum="490F88DE19FE7DDD" modified="2011-04-05" version="1">MSQQTPSRHRTFGFTTRQLHAAQVPDPVTGSRAVPLYQTTSYVFRDTEHAARLFSLQENGNIYTRIMNPTTDVLEQRIADLEGGVGALAASSGHAAQTMAILTLCEQGDHIVSASTLYGGTYNQFAYTFPRLGIEVTFVDPSDPENFRRAIRDNTKILYGETLGNPRINVFPFEEVSAIAREYQIPLMIDNTFATPYLCRPIEWGANIVTHSTTKFIGGHGTSIGGIIVDGGNFQWKDNPRFPNFNTPDESYHGLVYADLGPAAYIVKARVQILRDIGACQSPFNSWLFLQGVETLSLRMDRHVSNAQRTAEFLASHPKVRWVTYPGLPEHPDYHRAKKYLPKGAGAILGFGIEGGLEAGKRFIDRLQLFSHLANVGDAKSLAIHPASTTHSQLSPEAQLSAGVTPDFIRLSIGIEDIEDILWDLEQALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W0</accession>
    <name>E8N5W0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATP-dependent transporter SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ordered locus">ANT_17980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560202.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63824">
        <property type="protein sequence ID" value="BAJ63824"/>
        <property type="gene ID" value="ANT_17980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17980"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_0"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="256" mass="28551" checksum="4DA49D7C4C2F88FA" modified="2011-04-05" version="1">MSELVIKNLHVAIEGKEIIKGLDLTIRQGEVHAIMGPNGTGKSTLAYTLMGHPAYEVTEGEVWFKGQNILELEPDERSRLGIFLAFQYPVAIPGVTVANFLRTAINARRRAENPEDKGIPIPEFRKLLKSKMELLKMDPAFAGRYLNDGFSGGEKKRAEILQMAMLQPEIAILDETDSGLDIDALRIVAEGVNALRSKDLGVLVITHYQRILNYITPDFVHIMLGGRIVESGDADLALHLEEHGYDWVREKYEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N611</accession>
    <name>E8N611_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c-type biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccdA</name>
        <name evidence="3" type="ordered locus">ANT_18490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560252.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18490"/>
    <dbReference type="EnsemblBacteria" id="BAJ63875">
        <property type="protein sequence ID" value="BAJ63875"/>
        <property type="gene ID" value="ANT_18490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18490"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_2_0_0"/>
    <dbReference type="OMA" id="TSLTPCM"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="238" mass="25157" checksum="61C93B8E94942449" modified="2011-04-05" version="1">MEVTVGLAFLAGLASFLSPCVFSLVPVYVGYLSGRAVATAQSNSVADRWVTFSHGLAFVLGFSVVFITLGVAVSALGGLLYDLRTWIAKIGGILVMIFGLHMTGLLRIPFLEYDLRPRSSEDLSRSYLSSALMGVFFSAGWSPCVGPVLGAILTLALSGGSIAQGVSLLSAYSAGLAIPFLIAALGIGWVTKILRRYGKVMHYVEVGMGVILIIVGGMLFFGVFNLLSRFGTFVDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C1</accession>
    <name>E8N6C1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19590"/>
    <dbReference type="EnsemblBacteria" id="BAJ63985">
        <property type="protein sequence ID" value="BAJ63985"/>
        <property type="gene ID" value="ANT_19590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19590"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015903_2_0_0"/>
    <dbReference type="OMA" id="YWCLRWL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="231"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="608" mass="69328" checksum="43DC6E1D91ACBEB0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6E0</accession>
    <name>E8N6E0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560377.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19780"/>
    <dbReference type="EnsemblBacteria" id="BAJ64004">
        <property type="protein sequence ID" value="BAJ64004"/>
        <property type="gene ID" value="ANT_19780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19780"/>
    <dbReference type="eggNOG" id="COG2887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070318_0_0_0"/>
    <dbReference type="OMA" id="NWQTRLY"/>
    <dbReference type="OrthoDB" id="1283891at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="33589" checksum="7DD29313E42ED754" modified="2011-04-05" version="1">MLNRPVKRLASQPSFVFSQHSLQDYADCPRRFWLRYLEQLAWPSPPVEPLEEYERHRLLGEQFHRLAHQAFLGIDLNLLRQLAESDALLSSWWANFMRLFPAVNTGERKVEFALSVPVKQYRLFARFDLIQKHTAPLRWVIWDWKTGEKTSTASRLSQRWQTRVYRYVLVEAGQTIFGQNAPQPQDVEMVYWFAAAPEKSVRLPYSQEQFEKDREDILQWIEWIEKDDVFPPTTEEKRCRFCVYRSFCDRGIAGNLLDWEEEEEEPEAFSFNFDQVTEIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6E2</accession>
    <name>E8N6E2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560379.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19800"/>
    <dbReference type="EnsemblBacteria" id="BAJ64006">
        <property type="protein sequence ID" value="BAJ64006"/>
        <property type="gene ID" value="ANT_19800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19800"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025997_0_0_0"/>
    <dbReference type="OMA" id="FWLDAGS"/>
    <dbReference type="OrthoDB" id="207660at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="2">
        <location>
            <begin position="2"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="701" mass="80639" checksum="FB286A4D94BF2243" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK3</accession>
    <name>E8MXK3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sucC</name>
        <name evidence="9" type="ordered locus">ANT_20580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560454.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64084">
        <property type="protein sequence ID" value="BAJ64084"/>
        <property type="gene ID" value="ANT_20580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20580"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_0"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="313"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="41034" checksum="C7897190786D9399" modified="2011-04-05" version="1">MKLHEYQSKAIFHRYGVPIPKGRTTTMASEAKHFAEELGGKVVIKAQVLVGGRGKAGGIRLAKTPKEAEELATTILGMEIKGLPVRKILVDEAVSFEKEIYLGITNDRGARRPVMMASAAGGVDIEEVARVSPEKIIKIHIDPLLGLREYQARDLAVSIDLPRPLWRSFAEVAYGLWKAYTENDATLAEINPLVITSDKKLLALDGKMVVDDNALFRHPDLVEMRDLDAEDWAEIEARKFGLSYISLDGEIGCMVNGAGLAMATMDIIKLCGGEPANFLDIGGGAGAEKVAAALRIILSDPKVKAVLFNIFGGITRCDEVARGILTALAEVKPNIPMVVRLVGTNAEEGRRLLAEAKMITAETLLEAAQKAVAVVKGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT8</accession>
    <name>E8MXT8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21430"/>
    <dbReference type="EnsemblBacteria" id="BAJ64169">
        <property type="protein sequence ID" value="BAJ64169"/>
        <property type="gene ID" value="ANT_21430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21430"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654960_0_0_0"/>
    <dbReference type="OrthoDB" id="1618891at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225140" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="147"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="419" mass="45263" checksum="57C0F277FDA59048" modified="2011-04-05" version="1">MKRALLVVLQMAFLVLPVQAQSLPWVEMWVTVRDGVTGVVLADAQVENPLCEGLPADACTRYGVWNAERQAFILKIPRLEPYEVVVSKDGYETQVRSGTAVDAVTTWDVRLFPAQAGATFRVYLPLIMSSGTPLPPPVYDPVAAVGRLNWWRSLAGLPAVSGNLELHSACRAHARWMVNNGIAAHTEDPELPGYTIEGDACGQAANLAFGVDVFPGDEQAVDAMMASPFHALNALDGRLVEVGFGSARLETVWSGSYSAAALDVFHGQDWSLVPAPTTFPKDNGTLPVLSYNGLAQPDPLTACPGYTAPTGAALLAMYLPYPPGTIASTTLQQGSTLLEHCVIHGWSYHNPNRDLELQGRSALAERGALMIIPRLPLQAGKTYTMRVTWAGSQEVRWTFTTATEPLDILPLRVLLPHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW1</accession>
    <name>E8MXW1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_21660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560562.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64192">
        <property type="protein sequence ID" value="BAJ64192"/>
        <property type="gene ID" value="ANT_21660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21660"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_0"/>
    <dbReference type="OMA" id="LHEYETY"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="114"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="292" mass="33105" checksum="DEF5E9EDCCE310A2" modified="2011-04-05" version="1">MTDLQAFEAWLREQDRSDVTVRGYLADMSQFERWFEQTNGRGLRVEDVTPADVREYRAWLQTVQKASAATIRRRLMALRAYCRWGMAAGKIERNPTARLKMPREEKLSPGWLERSEQWRLVREAERGIQAADTPARRRLAVRDWALVVFLLHTGLRVSEACAVEVSDVQMGERSGWVQVRSGKGAKARKVPLNAEARRALKAWLEERGGQPGRMFEMTVSGVQRRLAEMGRRAGVEVHPHTLRHTLAKNLVDAGVGLQEVAALLGHSSLNATRVYVTPGERDLERALSRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW4</accession>
    <name>E8MXW4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560565.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64195">
        <property type="protein sequence ID" value="BAJ64195"/>
        <property type="gene ID" value="ANT_21690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21690"/>
    <dbReference type="HOGENOM" id="CLU_1412594_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="192" mass="21154" checksum="FDB7F0885EE92E7B" modified="2011-04-05" version="1">MNFANRVTLQGYLEIERAEEVSLDRDSSLTTPVLYGWLWTDTSGLLRHRVVLADKPAFGLLEMLRKFRPEGGSALVSLNGMAVEVVHLDGKPFVAVEGRLVDGVVNVKHVTVLSTPEAGLLRLLVDHRLREIVYGWEEIREADRVLMYRIVREAREAREPLSLTALGHGAPAGAWGGLTSTPPAPRRAAPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW5</accession>
    <name>E8MXW5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64196">
        <property type="protein sequence ID" value="BAJ64196"/>
        <property type="gene ID" value="ANT_21700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21700"/>
    <dbReference type="HOGENOM" id="CLU_134960_0_1_0"/>
    <dbReference type="OMA" id="ATHCEVG"/>
    <dbReference type="OrthoDB" id="1879806at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="15294" checksum="5170A088ACBFD03E" modified="2011-04-05" version="1">MSEKQLAQLSDKVIRHARRVQRALGSGHSELVYHRALLHELRQSGYEVLSQPRLKVRYAGQVVGEVVPDLLVRWFGCAVLVECKAAERFEQADFDQVRRYLRAYDGEAVGLLVGFGGARLEFRRVTIARKEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW9</accession>
    <name>E8MXW9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64200">
        <property type="protein sequence ID" value="BAJ64200"/>
        <property type="gene ID" value="ANT_21740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21740"/>
    <dbReference type="HOGENOM" id="CLU_697643_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="395" mass="44110" checksum="A349E0A5EC01C7D0" modified="2011-04-05" version="1">MRHSKKSVLGEVCMQQEMMGNQRLSVIPARAVSDPELSDGAFRTLAALGMFGDRNGWCYPSYATLAQIRGLSKSAIAKHITELVERGYLNIHHRFDEVSGAQRSSMLQIRFDYEPDEPGAGAKKTTKESPPRFRGGNPPYTPEVNGGYTSEVNGGYTPEVNPPYTLKGERLTSHINAPINAPVNGGGGVNDPVDVAETGTPPPPPPPPNPTDDLLNRAEKLYRMVRPSHLMIPRTRWYEDALQVLNQTLDKHNGDYERAAGELRRYAEEADRRNIAPTNLCWLTEWAAAGKVPPPRRGARGNGNGQKAVEERRDRVLQETRKRFGWGSDALVYSFDIERLEKLLELWPLLEARGATDEDTFRMLAWHVEVPVEEIKRRLEVGEGIDLDAEFGFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY0</accession>
    <name>E8MXY0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21850"/>
    <dbReference type="EnsemblBacteria" id="BAJ64211">
        <property type="protein sequence ID" value="BAJ64211"/>
        <property type="gene ID" value="ANT_21850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21850"/>
    <dbReference type="HOGENOM" id="CLU_2244333_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="104" mass="11574" checksum="7F8A21B056DE52FE" modified="2011-04-05" version="1">MILSLAYIGKTGEKGSEWLLPIMLGWMAGLGGNIVERDPGEGMLKAGMAQTTFLLAWVIPRGLPSETVLFALVWLFHTVTTMLAVYLEVARVRAQRQLKTTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY9</accession>
    <name>E8MXY9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_21940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21940"/>
    <dbReference type="EnsemblBacteria" id="BAJ64220">
        <property type="protein sequence ID" value="BAJ64220"/>
        <property type="gene ID" value="ANT_21940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21940"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465148_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011429">
        <property type="entry name" value="Cyt_c_Planctomycete-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005126">
        <property type="entry name" value="NapC/NirT_cyt_c_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03264">
        <property type="entry name" value="Cytochrom_NNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07635">
        <property type="entry name" value="PSCyt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_NNT" evidence="5">
        <location>
            <begin position="25"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PSCyt1" evidence="6">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="586" mass="64821" checksum="83BD341B96A43271" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY01</accession>
    <name>E8MY01_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560601.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22060"/>
    <dbReference type="EnsemblBacteria" id="BAJ64232">
        <property type="protein sequence ID" value="BAJ64232"/>
        <property type="gene ID" value="ANT_22060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22060"/>
    <dbReference type="HOGENOM" id="CLU_2257865_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="103" mass="11161" checksum="6CF38784B5251055" modified="2011-04-05" version="1">MEILLTPPVALLIYIGVVLLIVWFGRQLAGIYHRDPLKSQLYASGEEAPTYLAAPGYRPFFLVALFFALLHLGMLVLGLSQFSTASLIYGVGLAIGLLVLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY71</accession>
    <name>E8MY71_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_22760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560669.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64302">
        <property type="protein sequence ID" value="BAJ64302"/>
        <property type="gene ID" value="ANT_22760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22760"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040020_1_0_0"/>
    <dbReference type="OMA" id="FGFHRMM"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="414" mass="44600" checksum="4A794FBD5BFFD5FD" modified="2011-04-05" version="1">MAQEISAPKTKIGRLPRNIWAVSLTSFFMDISSEMVLNILPLFLANVLGIRTSLIGLIEGIAEATSSLLKVFSGWLSDRLKGRKWIAVVGYGLSAISKPFFYFASTWEAVAAIRWTDRVGKGVRTAPRDALVADSVEPEVRGLAFGVQRAADTAGALLGILIAAGVVWWAQSNQVALGAETFRTVVLISIIPGVLAVLSLAIGAKDVPLKNRGEAPRLAFRSLGKPFMVFMIIVGIFDIGNSSDAFLVLRAQERGLSTLGILLMLAAFNLVYTLLSAPAGSFSDRIGRRKVIIGGWLVYSAIYFGFAFAQQAWHVVVFYILYGVYYGLAFGTTKAMVADLVPEALRGTAYGTYNAILGILDFPASLIAGILWQGVGHWQGFGASAPFFFGALMSILAAILMMLWKPASSETQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA8</accession>
    <name>E8MYA8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558451.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00190"/>
    <dbReference type="EnsemblBacteria" id="BAJ62053">
        <property type="protein sequence ID" value="BAJ62053"/>
        <property type="gene ID" value="ANT_00190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00190"/>
    <dbReference type="HOGENOM" id="CLU_1987994_0_0_0"/>
    <dbReference type="OrthoDB" id="2225028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="125" mass="13895" checksum="5FCD4A6B174AF8AA" modified="2011-04-05" version="1">MPEKSRQIIVGGGGFFRTLSNQVRLIARLVADRRVSPLVKVLPIASVVYMFIPTDALPLLPFDDAALIWLANSLFLEMCPQDVVEEHRRAIEGDTTIVEIPPQKPAPEDDNIIDAEFREEGPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF4</accession>
    <name>E8MYF4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558497.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00650"/>
    <dbReference type="EnsemblBacteria" id="BAJ62099">
        <property type="protein sequence ID" value="BAJ62099"/>
        <property type="gene ID" value="ANT_00650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00650"/>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_0_3_0"/>
    <dbReference type="OMA" id="RLYTGIT"/>
    <dbReference type="OrthoDB" id="2077602at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="88" mass="10226" checksum="33557C8417AA52DC" modified="2011-04-05" version="1">MSACYCYLLECADGTYYTGWTTDPQRRARQHNAGRGARYTRTRLPVRLAYIEPQPDRATAMRRERQIKRLSHAQKQALCASFVNLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYL2</accession>
    <name>E8MYL2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase A inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kipI</name>
        <name evidence="5" type="ordered locus">ANT_23220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560715.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64348">
        <property type="protein sequence ID" value="BAJ64348"/>
        <property type="gene ID" value="ANT_23220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23220"/>
    <dbReference type="eggNOG" id="COG2049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020207_1_0_0"/>
    <dbReference type="OMA" id="MPWMLAA"/>
    <dbReference type="OrthoDB" id="1848526at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="221" mass="24098" checksum="9810E7A952C8B683" modified="2011-04-05" version="1">MALTFPDWIQPCGDSSLLIILGGQISISLNRQVHAMAHGLKARGISGLEEFVPGYATLRVDYDPLKCSVEDLLYHIQEVRESLPEDSALPAREVVIPVHYGGEDGPDLPFVAQYTGLSEEEVIRRHTAGRYPVFLMGFLPGFPYLGGMDESLAAPRLDTPRQRVPAGSVGIAGKQTGVYPLDSPGGWRIIGRTSLTLFDVTREPPFLLQPGDVVRFVAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ5</accession>
    <name>E8MYQ5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560757.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64391">
        <property type="protein sequence ID" value="BAJ64391"/>
        <property type="gene ID" value="ANT_23650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23650"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355164_0_0_0"/>
    <dbReference type="OrthoDB" id="907022at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="497"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="772" mass="86273" checksum="D4E9690CABF201B4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYV8</accession>
    <name>E8MYV8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560799.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24180"/>
    <dbReference type="EnsemblBacteria" id="BAJ64444">
        <property type="protein sequence ID" value="BAJ64444"/>
        <property type="gene ID" value="ANT_24180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24180"/>
    <dbReference type="HOGENOM" id="CLU_1500553_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19647" checksum="A4D9FC887B0A31DE" modified="2011-04-05" version="1">MEWYTPFVWIANGLLALVWLLVEHLWQVGLAGALGYAVLRAPVSQQRWTLGVAVLALLAGLLAPFPVALFLLVMTLAGLLAVRLERFNPQNTHWMLVRGLGLYALTGLGFAAYREWLLPALSAPALLQGQAYLNAIASIALYLLPLGYLALLAQGLLVHPPVQQDADEIIYHFRSRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY0</accession>
    <name>E8MYY0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560821.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24400"/>
    <dbReference type="EnsemblBacteria" id="BAJ64466">
        <property type="protein sequence ID" value="BAJ64466"/>
        <property type="gene ID" value="ANT_24400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24400"/>
    <dbReference type="HOGENOM" id="CLU_1238098_0_0_0"/>
    <dbReference type="OrthoDB" id="2153762at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="223" mass="24721" checksum="F8C59FC5147C6EEA" modified="2011-04-05" version="1">MVQIVPVKVRIVPQVNVNRPSRVIPRRLDEVVMRLPVLTHATAVLGVGEDGVPVVWDALGGKSLLILGEGLALPWQVLDAARVSLEQHNTRHLVEITWVTEREARGHRITDVVCPHDRALEQALYRLADLVDRRRHGQNRGATQVLILDDLAQVLKADVEAHWALEFVLKHGGKNGVQVLAGADYRALTRRPVKGWDGRFGSVLRQVGDRFSTPTGTVIPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ03</accession>
    <name>E8MZ03_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_01120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558544.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62146">
        <property type="protein sequence ID" value="BAJ62146"/>
        <property type="gene ID" value="ANT_01120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01120"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355534_0_0_0"/>
    <dbReference type="OMA" id="ERTQFFG"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="716"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="768"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="436"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="701"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="802" mass="87864" checksum="E3431EFFD1BA5AF9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ10</accession>
    <name>E8MZ10_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558551.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01190"/>
    <dbReference type="EnsemblBacteria" id="BAJ62153">
        <property type="protein sequence ID" value="BAJ62153"/>
        <property type="gene ID" value="ANT_01190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01190"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388180_0_0_0"/>
    <dbReference type="OMA" id="SGWDTDC"/>
    <dbReference type="OrthoDB" id="137159at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="698" mass="76540" checksum="1A0F4106905729D5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ16</accession>
    <name>E8MZ16_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_01250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558557.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62159">
        <property type="protein sequence ID" value="BAJ62159"/>
        <property type="gene ID" value="ANT_01250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01250"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_3_0"/>
    <dbReference type="OMA" id="VYVKNWS"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="167"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="37431" checksum="4969AA07FF48F3F8" modified="2011-04-05" version="1">MQTNLRGRDFIGDLDFSKEEVETVLDVAWDLKRKRALGEPHPLLRDKTLAMLFFFTSTRTRGSFEAGMAQLGGHAAFIDSDTTQIAHGDTAKEIGEIFGRYFDGIAIRQCDWQFGNKYINEVARYSRVPVLNMQDDIYHPFQCLADLMTIMEKKGRDLRRRKIVVSWAYAASYSKPISVPQSLILQLTRFGADVVLAHPPEFKLMPEIVEMARENARKYHSGFEIVHDMDEAFKDADVVYPKSWGPLVTTTDKNEGKVLIEKYRDWITDQRRMDLTKEDSIYMHCLPADRNLEVTDEVIDGPHSVVYDEAENRLHVQKAVMALTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ30</accession>
    <name>E8MZ30_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_01390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558571.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62173">
        <property type="protein sequence ID" value="BAJ62173"/>
        <property type="gene ID" value="ANT_01390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01390"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="OMA" id="RAWWVVS"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="100"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="36135" checksum="F8C2E4BF450F55ED" modified="2011-04-05" version="1">MATKAATVSSESMRTVKEETPFAIVMRRFRKHRLAMISLGVMIFIFLVSLFAQQIAPFEPDEVDVNARFVAPGTTVQGKLHLFGTDNIGRDYFSRLLYAGRISLTVAVLSVLISELIGIVIGSISGFYGGWIDTILMRFVEFLLTIPSLPLLLIVSSMLIRNPDLIPIPDVVLNVLGKVMLLRPSDARQAVLIVIVLAGLGWLTSAQLMRGMILTLREQTFVEAARSLGASNTRIIFVHMIPNALAPIIVDASLALAGYIVAEASLSFLGFGIQDPIPTWGNMLSATQTYMYDRPWLPLIPGLPIFLCSLAFNYIGDGLRDALDPRLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ67</accession>
    <name>E8MZ67_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558608.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01760"/>
    <dbReference type="EnsemblBacteria" id="BAJ62210">
        <property type="protein sequence ID" value="BAJ62210"/>
        <property type="gene ID" value="ANT_01760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01760"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="QLWGYPP"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="139"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="139"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="238" mass="27782" checksum="AF0636875DC86945" modified="2011-04-05" version="1">MAEKILVVEDERALQETLEYNLKRQGYEVQVAGDGILALDLAREFQPEIILLDVMLPGMDGFELCRRLRQEMNTPVLMLTARTEEIDRVVGLEVGADDYMTKPFSMRELLARVKAMLRRVRMIREEMQKSEESTQKESEKRLLSGNLELNLARREVRLNGVVVAVKPKEFELLHFLMKHRGQVLSRDYLLKELWGWDYFGDSRTVDVHIRWLREKIEPDPAHPVRIVTVRGAGYRFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ70</accession>
    <name>E8MZ70_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558611.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01790"/>
    <dbReference type="EnsemblBacteria" id="BAJ62213">
        <property type="protein sequence ID" value="BAJ62213"/>
        <property type="gene ID" value="ANT_01790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01790"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="OMA" id="LTMTNGQ"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="33307" checksum="4270EB1BEC9C23A7" modified="2011-04-05" version="1">MFKNKDRYLSFLLVLPSILAVMIFIYGFIGWSIRVSLSQWKGLNPNFAWAGLNNYIELFSDPRFMVDIRNTVIFTVVFVVGCIVVGFFLAVMLDQGLKGEAFFRTLFLFPMAISFIVTGVVWRWLMNPATGSRMSGLNLLFSYLHLDFLINNWHTTPTWGIAAVALAAIWQMSGYTMALYLAGLRSIPLELREAAQIDGASEWQIYRHVILPILTPVTLSALIILGHISLKVFDLIIAMAGKQLALDVPAIYMWQTTFDGLFYARGAAIATLLLISVAVLIIPYMWFTLRSEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD4</accession>
    <name>E8MZD4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560837.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64482">
        <property type="protein sequence ID" value="BAJ64482"/>
        <property type="gene ID" value="ANT_24560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24560"/>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122744_0_0_0"/>
    <dbReference type="OrthoDB" id="1806242at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="15099" checksum="E4BCF0DC2901C7EC" modified="2011-04-05" version="1">MILLNFSHPLTSSQKEQIEALTGQALDKVLDLAVHFDNQLPFIPQLEALMENIPLSPAQWQNEPIPINPPSLNFITALLIAELHGRMGYFAPIVRLRPKAGSLPPQYEVAEILNLNEVRERARTHRYRNGENGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR3</accession>
    <name>E8MZR3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative S1B family peptidase</fullName>
            <ecNumber evidence="2">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560966.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25850"/>
    <dbReference type="EnsemblBacteria" id="BAJ64611">
        <property type="protein sequence ID" value="BAJ64611"/>
        <property type="gene ID" value="ANT_25850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25850"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_0_0"/>
    <dbReference type="OMA" id="WRYATEQ"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="268"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="390" mass="41060" checksum="8A5E9DE475103FCC" modified="2011-04-05" version="1">MKHRISLFFGVIFLALVTLACRFTLPETLQPIPSPTAAAPVTVQTPAVEPPASVSVPDLVSHQDRLVALYEQVNPGVVSLQVLTETGGSQGSGFVYDREGHIITNFHVVDGATDLEVDFPSGIKVRGEVIGTDPDSDLAVVKVNVPPEELHPLPLGSGEAVKVGQTVVAIGNPFGLSSTMTLGIVSAKGRTLESLREAPQGGFFSTGGLIQTDAAINPGNSGGPLLNLNGEVIGVNRAIRTTTMTALGEPTNSGIGFAVNVDIVARVVPELIKNGKYDYPYLGVSSQEEITLMMQEALGLPRATGAYVLEVRPNSPAARAGLRAGTRSSSIPGLPAGGDLIIAVDGRPVRVFGDLLSYLMIYKRPGDTIVLTILRDNKEMEVTVTLDKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU5</accession>
    <name>E8MZU5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_02460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558677.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02460"/>
    <dbReference type="EnsemblBacteria" id="BAJ62280">
        <property type="protein sequence ID" value="BAJ62280"/>
        <property type="gene ID" value="ANT_02460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02460"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_0"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="267"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="514" mass="56936" checksum="2E937242E37BA3A9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW7</accession>
    <name>E8MZW7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative sodium/hydrogen antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_02680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02680"/>
    <dbReference type="EnsemblBacteria" id="BAJ62302">
        <property type="protein sequence ID" value="BAJ62302"/>
        <property type="gene ID" value="ANT_02680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02680"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_0"/>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="14"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="405" mass="42569" checksum="2A1E3864A7E77486" modified="2011-04-05" version="1">MPMSPFLQLSITLAIIIFAAKIAGWVSQRFGQPSVFGELLVGVLLGPSLLNLTHLPFITDSHLDEIVRELGEMGVLILMFLAGLELELGEMARNGRVSVLAGLLGVVFPVGLGAAVGFASGMETRSALFLGLALGATSVSISAQTLMELGILRSRVGLGLLGAAVFDDIFVILLLSVMTALVDGASGASAVIMTILRMAGFLVLSVLVGMYVLPFFSRLLARLQISRGNVAMAVVVMLVYAVAAELIGGMAAITGAFLAGMMVGRSGEKRSVENGFAMLGYSFFIPIFFVDVGLRINLTELPLEALWLALIVSLVAVAGKWIGAGLGAKLAGFTWRESMQLGAGMISRGEVGLIVAAIGLSEGLLSREFFSTVVGMVLISTLITPPLLRWVCTLPSPKPKVREVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY6</accession>
    <name>E8MZY6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_02870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558718.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02870"/>
    <dbReference type="EnsemblBacteria" id="BAJ62321">
        <property type="protein sequence ID" value="BAJ62321"/>
        <property type="gene ID" value="ANT_02870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02870"/>
    <dbReference type="eggNOG" id="COG3339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139031_0_1_0"/>
    <dbReference type="OMA" id="PRVPWYA"/>
    <dbReference type="OrthoDB" id="2017850at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="6">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="14913" checksum="A21A1AA6C9B4BA06" modified="2011-04-05" version="1">MKQWLKKFRERAEALEKEACVLVQAYRHPRTPWYARALAVLVLAHTFSPIDLIPDFIPVLGVLDDWIITPLGIALVIRLIPPEVMAEARRQVEENGSASPALRRLGAALVILLWLVVLVWLGRALGLGMKSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N002</accession>
    <name>E8N002_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_03030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558734.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03030"/>
    <dbReference type="EnsemblBacteria" id="BAJ62337">
        <property type="protein sequence ID" value="BAJ62337"/>
        <property type="gene ID" value="ANT_03030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03030"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_4_3_0"/>
    <dbReference type="OMA" id="MVPCVEE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="342"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="375" mass="40575" checksum="FD7B7BE583DBE161" modified="2011-04-05" version="1">MVDLSLHLWGHTFRNPVIPAAGPNVGSGRMVRRAAEGGAGGLLTKTISSRAAPVPHPNMVRFGTAGMLNTELWSELPPEVWFQKEYNEALAAAREYGLPLIASVGYSAEDLAVLAPRLQDKGVDIIEFSVHYLDAERLIETAQLLREVVTLPIIAKLSPHLGDLGAFVRLLDPYVDGYACINSFGPTLSIDIEHGGEPYLGSKFGYGWMSGAPLKPLAVRSVFEAARVTDKPIIGVGGITRGEDVIEFLMAGASMVGVCTAAILRGPDIYGKIAAETARWLEEHGYSSLQEVKGKFLEKYRNGQRVVTSLEQVAVVDEARCKGCGVCERVCQYDALRAPQKQVAQVDAELCAACGLCVSVCPHDALSLRLRWEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N039</accession>
    <name>E8N039_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_03400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558771.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03400"/>
    <dbReference type="EnsemblBacteria" id="BAJ62374">
        <property type="protein sequence ID" value="BAJ62374"/>
        <property type="gene ID" value="ANT_03400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03400"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_60_4_0"/>
    <dbReference type="OMA" id="TVCVWTL"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="403" mass="43825" checksum="23DD1BDC23295EF0" modified="2011-04-05" version="1">MLSRLHSHPYPRQFWLMFAGMLISTTGASMIWPFLMIYASEKLSLPLGTVTLLMTLSSFMGLMSSFIAGPIVDRLGRKWAMAVSLLINGGGYLLLSRAETLPAFALAMAVNGTFNPIYRVGADAMLADLIPPQWRTNAYALMRMSNNVGVALGPAIGGFIASRSYGIAFYCAAAGLATYGLLVLLFARETLPQGAPEPQSEPLGGYGQVLSDRLYRAFLVAFTLNQMVAALIWVLLSAHVKRAYGISESLYGWLPTTNALMVVFFQYGVSKITQRYEPRRMMALGAFLYGLAALGIAFSTTYWAFWTCMVVMTIGELIIVPTSSTFAANLAPAHMRGRYMSLYGLTWGVSAGISPLVGGNLYEWLGARAMWLGGTLVGSLSSLLFLRMRQRIPAEVTETAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N049</accession>
    <name>E8N049_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ordered locus">ANT_03500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558781.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62384">
        <property type="protein sequence ID" value="BAJ62384"/>
        <property type="gene ID" value="ANT_03500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03500"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_0"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="249" mass="28735" checksum="6AA7CBC9C4DE70B9" modified="2011-04-05" version="1">MDVSTSTPTLTKVPVHVAMIMDGNGRWAQKRGLPRLAGHRAGTENLRRIIRASVEFGVKYLTIYAFSTENWGRPQEEVEGLLHILEEVIDRELDELDQQGVQLRHLGHLDRLPAMLQEKIIRAVERTRDNDRLILSVAFNYGGRDEIVCAIRAMMRDSVKPEEVTPELVSRYLFTADLPDPDLIIRTSGEMRVSNFLIWQSAYSEWYVTPVLWPDFDREEYLKALIEYSHRERRFGKLTAQDDSTDCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N062</accession>
    <name>E8N062_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558794.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03630"/>
    <dbReference type="EnsemblBacteria" id="BAJ62397">
        <property type="protein sequence ID" value="BAJ62397"/>
        <property type="gene ID" value="ANT_03630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03630"/>
    <dbReference type="eggNOG" id="COG5322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007311_0_0_0"/>
    <dbReference type="OMA" id="YEAGCKL"/>
    <dbReference type="OrthoDB" id="1106190at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="306" mass="33963" checksum="B790FBD05D9FAB34" modified="2011-04-05" version="1">MKRAVSISIGSSKRNKTVEIELLGERVRLERIGTDGDMDKAAQLYRELDGKVDAFGVGGTDLGLRVADRWYPLHSVSRLVRDVRQTPVVDGTGLKATLEKRVAGVLEQLAPSLPEKTALVTTAVDRWGLAEAALNAGFRVTFGDLIYSLGIPIPLHSPRSIRLMAALLLPVLSRLPFEWLYPVGEKQGQRNPKHTRFFQQAAVVLGDCHYIYRYMPDDMRGKVIVTNTTTPEDVQTFRASGVRWLITTTPVLEGRSFGTNMMEAAILAAAGRREPVNYAQADGYYRWLDGVLDELKLSPQVQELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N088</accession>
    <name>E8N088_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560991.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26110"/>
    <dbReference type="EnsemblBacteria" id="BAJ64637">
        <property type="protein sequence ID" value="BAJ64637"/>
        <property type="gene ID" value="ANT_26110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26110"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_605137_0_0_0"/>
    <dbReference type="OMA" id="TINHAAM"/>
    <dbReference type="OrthoDB" id="516544at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="443" mass="48740" checksum="90BF817AD02C4D4B" modified="2011-04-05" version="1">MSPINPFILILWLFLHLLLGILFSQYPALSTLHAITTLVIGTLVVLGRNYRRVLYVAAYITGAEVLWRMTGANVFWEYGKYATVFLLGLALMRLPRWRGVRMPLLYFSLLLPSIILTVLDLGLTEKARSAISFNLSGPLALAICALFFFQVRLSGEERKTILWVTIAPLLAVLAVILRTIRSVGIVAFTDESNFVTSGGFGPNQVSALVGLGALLCILLFISTRRLGERWIAGVLALTFLIFSVLTFSRGGVYNVAGALILALPSMLANPRLRNALILFLLIGLMVASLWAVPFLDSFTQGMVRVRYANLETTNRLEIMQAQLQVWGEHPLLGVGPGMAKYASLQLLGYDVAAHTEYTRVLAEHGFFGVLALLVLLSMAVQAWGRAQTPLQKTLTTALLAWPLLEMSHAAMRVVAIAFIFGLALAGWAENRHNSIQKTGNQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J7</accession>
    <name>E8N0J7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatidyltransferase</fullName>
            <ecNumber evidence="3">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561098.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64746">
        <property type="protein sequence ID" value="BAJ64746"/>
        <property type="gene ID" value="ANT_27200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27200"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077956_0_0_0"/>
    <dbReference type="OMA" id="RPRYGFY"/>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="272" mass="31032" checksum="D557210263E446BD" modified="2011-04-05" version="1">MENQIKNHVRVNETILRPLEKKALEWLAARMPAWVNPDHLTALGIFASLLISISLILTNFSPSFLWLANLGVFLNWFGDSLDGTLARYRKIERSNYGYYIDHAVDAVSEALVFMGLGLSPYVRVEFAMLALITYLMMSIQVFLYSQVKGIFQISFLRLGPTEVRLIMILSNIFVFYVGNPTFSSLLGTFTMYDLVALFIALLLFSAFIIVTIIHARELAAFDENLLRLRAEREARKAERAARKAERAANRRARRVKPQRFVLPVKFHLPGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0K1</accession>
    <name>E8N0K1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561102.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64750">
        <property type="protein sequence ID" value="BAJ64750"/>
        <property type="gene ID" value="ANT_27240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27240"/>
    <dbReference type="HOGENOM" id="CLU_1458441_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="185" mass="21209" checksum="A97B831D430B6990" modified="2011-04-05" version="1">MNEIRTAQAGDICVLLMPEPEDLPPIRQMQEELMRTFGGWISAEVHVTCQRFEPPLDRKVHEVVLNLRTALARFPAFPVIASGLTQFHAPFWQSYVLRWEVEYTPEFKAFILALDGLLEQAGIQPHYPHDTPFTCSAIDLITPVQLEYAPVYSYPMHLFTARRVIFSRVMGLNDFETLGFAQLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0M9</accession>
    <name>E8N0M9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558820.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03900"/>
    <dbReference type="EnsemblBacteria" id="BAJ62424">
        <property type="protein sequence ID" value="BAJ62424"/>
        <property type="gene ID" value="ANT_03900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03900"/>
    <dbReference type="HOGENOM" id="CLU_1438350_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="188" mass="21157" checksum="377722457610C539" modified="2011-04-05" version="1">MNIFPFTARVGVRLGWVIGLGIAALILVPVLLFAWVANLPEVYPYTLLKSEAGTLGLAVFSLLVVGILFILLWGWFSTGKIVVNSSGMKWEIEGEKGFIRWDQPFSLHRWRSVYESGGTSYDQPSMTLPVIVYRVAQGDSCLTFWYGESWKKIQDLPDGPLAGVMLFHHARKLAKTIDEMYQQSLKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U3</accession>
    <name>E8N0U3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplS</name>
        <name evidence="8" type="ordered locus">ANT_04540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558884.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04540"/>
    <dbReference type="EnsemblBacteria" id="BAJ62488">
        <property type="protein sequence ID" value="BAJ62488"/>
        <property type="gene ID" value="ANT_04540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04540"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_2_0"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="115" mass="13100" checksum="769C16FB46DC0AFD" modified="2011-04-05" version="1">MSEQILKAIEPQPNPNVPPLRPGDVVSVHVKIKEGNRERVQEFKGTVLFTKNAGAGSTFTVRRVASNGIGVERTFLTYSPRIEKVVVERHSKVRRARLFYLRNRTGKSARLKQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N129</accession>
    <name>E8N129_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64772">
        <property type="protein sequence ID" value="BAJ64772"/>
        <property type="gene ID" value="ANT_27460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27460"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1700594_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="154" mass="17823" checksum="EC8670C4499A37A1" modified="2011-04-05" version="1">MPERKRRARFLLPRLNLSFLQRRPPDGKPRPWMDSRLRQQIILVVVLLLLALVFASLNQRISQNIRLTTQRDQLSTQVMQLTATVQALETRKAYITSEAAVEEFARDRRMIREGDVLVVPLTPVGKPTPTPLGFPTPQPPPQNWEVWWALFFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N147</accession>
    <name>E8N147_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561138.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64790">
        <property type="protein sequence ID" value="BAJ64790"/>
        <property type="gene ID" value="ANT_27640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27640"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_5_0_0"/>
    <dbReference type="OMA" id="YKPAFMY"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="421" mass="46952" checksum="7B5FFD32DF25A439" modified="2011-04-05" version="1">MKKLVILGAGTAGTMAANRLSRILNTSEWEITLVDPNPVHYYQPGFLFIPFGVYQEKDAVKPKKAFIPRGGKLLQTAVEEILPSQNKVRLANGETLSYDYLIIATGTDIHPEETPGLAEHEWGKSIHTFYSLEGAVALAGALRNWKGGRLVVNVVENPIKCPVAPLEFLFLADWYFTQRGMRDRVELIYATPLPGAFTKPIASRMLGDMLEKRRIRVEPEFMLMEVNPDAKKLVSYDEREVEFDLLVSIPLNKGAEVIGRSGLGDELNYVPTNKHTLLAEGYDNIFVLGDATNVPASKAGATAHYEVDTLAENFPRYIQGKELEPLFDGHANCFVETGYGKGMLIDFNYTTEPLPGKYPLPLIGPFSLLKESVINHWGKLGFRWMYWNILMKGLPIPFLPAQMSMVGKEKVNWENGGAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N183</accession>
    <name>E8N183_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_28000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561173.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28000"/>
    <dbReference type="EnsemblBacteria" id="BAJ64826">
        <property type="protein sequence ID" value="BAJ64826"/>
        <property type="gene ID" value="ANT_28000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28000"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_16_0"/>
    <dbReference type="OMA" id="AHEGRIW"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="310"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="425"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="641" mass="70901" checksum="C0A2A4409C948401" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N196</accession>
    <name>E8N196_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561185.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28130"/>
    <dbReference type="EnsemblBacteria" id="BAJ64839">
        <property type="protein sequence ID" value="BAJ64839"/>
        <property type="gene ID" value="ANT_28130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28130"/>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_0_0"/>
    <dbReference type="OMA" id="KEWTEVK"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="76"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="15167" checksum="04FF9D21E798032B" modified="2011-04-05" version="1">MQFKVRDWMIDLVVMVEPDLPVTEVLATMRRRYIHSVIVNKSAEHPEYGIITSTDICDKIVAAGRNPAKIKAAEIMSSPIITVSPEMKIDECAKLMSEKGIHHLPVADKAGNVIGMISATDFLVVAEAMGRDGDRSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1B6</accession>
    <name>E8N1B6_ANATU</name>
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        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recJ</name>
        <name evidence="9" type="ordered locus">ANT_28330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
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        <property type="protein sequence ID" value="BAJ64859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28330"/>
    <dbReference type="EnsemblBacteria" id="BAJ64859">
        <property type="protein sequence ID" value="BAJ64859"/>
        <property type="gene ID" value="ANT_28330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28330"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_4_0_0"/>
    <dbReference type="OMA" id="LIVTCDT"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="77"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="320"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="457"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="767" mass="85012" checksum="95476FE1BB1A35A4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F5</accession>
    <name>E8N1F5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_28720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561243.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28720"/>
    <dbReference type="EnsemblBacteria" id="BAJ64898">
        <property type="protein sequence ID" value="BAJ64898"/>
        <property type="gene ID" value="ANT_28720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28720"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="OMA" id="IDRVWGS"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="225" mass="25975" checksum="79706A1B386A2F00" modified="2011-04-05" version="1">MKERILIIEDDEGIVRVLKRALTYEGYLVESALEGETGLQLAREHRPDLIILDWMLPGMDGLEVCQRLRTLCNAPILMLTAKDTLQDRVQGLDAGADDYMTKPFELEELLARIRALLRRTQMERAPVLSFADLTLDTSTRQATRGNRTIPLTAKEYDLLELFLRHPRQVLTREMIFDRVWGYDFGGESNVLDVYIRYLRQKLESDGEPRLLHTVRGVGYVLRETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G2</accession>
    <name>E8N1G2_ANATU</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561250.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64905">
        <property type="protein sequence ID" value="BAJ64905"/>
        <property type="gene ID" value="ANT_28790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28790"/>
    <dbReference type="eggNOG" id="COG1545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119412_2_2_0"/>
    <dbReference type="OMA" id="LRHARYR"/>
    <dbReference type="OrthoDB" id="1756670at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="135" mass="15115" checksum="9BDC835B67BE1E68" modified="2011-04-05" version="1">MENPRHWRIRKQRYALVGEVCPHCEVKIFPPRDVCPNCGGEAKTQFAFSGKGTVFSFTVMNDAPAGYEKNLPYAVALVKLEEGPIVTAQLTDLGDQPVEIGMPVEMVTRRIRDDGDEKGIIVYGYKFRPAFASQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G5</accession>
    <name>E8N1G5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
            <ecNumber evidence="3">1.1.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mvaA</name>
        <name evidence="4" type="ordered locus">ANT_28820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:14833"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; (R)-mevalonate degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.88" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561253.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28820"/>
    <dbReference type="EnsemblBacteria" id="BAJ64908">
        <property type="protein sequence ID" value="BAJ64908"/>
        <property type="gene ID" value="ANT_28820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28820"/>
    <dbReference type="eggNOG" id="COG1257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033422_0_0_0"/>
    <dbReference type="OMA" id="GHMKMHL"/>
    <dbReference type="OrthoDB" id="617929at2"/>
    <dbReference type="UniPathway" id="UPA00257">
        <property type="reaction ID" value="UER00367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140643">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="425" mass="45433" checksum="000FEAA119AC83C8" modified="2011-04-05" version="1">MAETGVKFYDLPLEERRRWVAEQAGIPLSEVEMLSGLPGLTPEQADHMIENVIGVYGLPLGIARYFRVNGRDVLVPMALEEPSVVASASFMAKLALQGGGFFATASAPEMIGQMQVLDLDDPASARLKILEHRQELLDEATAVDPVLAKLGGGARDLEVRLIADSPIGAYLVVHLIYDVRDAMGANAVNTAMERLAPKVEYITGGRVHLRILTNLAERRVARARCTIPVSALAFEGYTGERVRDGIIEAWAFAASDPYRAATHNKGIMNGVDAVVIATGNDWRAVEAGAHAYAARLGRYTSLSTWGKDREGNLVGTLEMPMAVGIVGGATRVHPAARAAIQLMGVKSASELAQIIVSVGLAQNLAALRALATEGIQRGHMSLHARQVAIAAGAVGDLIEKVASRMVAEKVVRIDRAQEILKELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H7</accession>
    <name>E8N1H7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_05480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558978.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62582">
        <property type="protein sequence ID" value="BAJ62582"/>
        <property type="gene ID" value="ANT_05480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05480"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="LMEEVFQ"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="294" mass="32560" checksum="A11CB3E349AECA29" modified="2011-04-05" version="1">MIEIENLTKVYPNGKRALNSLSLNIHEGMFGLIGPNGAGKTTLMRILATLLTPTAGRVLIFGKDLQTPEGKVSTRKSLGYLPQEIGFHLKLTVEQELDYFAILKNITDPKDRNRQIDNVLEQIGLRSARKERIHTLSGGMKRRLGIGIALLGSPKLLIVDEPTASLDPAERVHFRNLLFQLAGKRIVILSTHIIEDVNQVCSDLAVITNGNLLFHGAPEILLSQVKGKVRIVPESELNAEKNLRLISSKTTPSGTEHRVLSSEKPSHTSENIEPTLEDAYLWLIQQTSEESENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I5</accession>
    <name>E8N1I5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558986.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62590">
        <property type="protein sequence ID" value="BAJ62590"/>
        <property type="gene ID" value="ANT_05560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05560"/>
    <dbReference type="HOGENOM" id="CLU_2327763_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="98" mass="10425" checksum="23F528ED65E845E9" modified="2011-04-05" version="1">MNEKTSSVIQYADLRVLAMLGVLLFFLFLSMGSGMMQSSPVEATPTSEGEMLAPTVTPLPPEYLGNYAQTTGIILATSVIVLIVVGGVLYGLLSNKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K1</accession>
    <name>E8N1K1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559001.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05720"/>
    <dbReference type="EnsemblBacteria" id="BAJ62606">
        <property type="protein sequence ID" value="BAJ62606"/>
        <property type="gene ID" value="ANT_05720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05720"/>
    <dbReference type="eggNOG" id="COG3427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046420_0_1_0"/>
    <dbReference type="OMA" id="YEAIVTQ"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05018">
        <property type="entry name" value="CoxG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010419">
        <property type="entry name" value="CO_DH_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38588">
        <property type="entry name" value="PTHR38588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06240">
        <property type="entry name" value="COXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="207" mass="22122" checksum="6F8931DE7E6BF4D3" modified="2011-04-05" version="1">MQLEGEHVFKGPREEVYAMFRDPEVLASALPGTQSLNKIDDQHYEGAMNIRIGPVSGSFSGKLEVADEVAPEKCTLIVEGRGAPGFAKGVGRVEFIDQGDGTTLMKYSGDVQIGGTLASVGQRMIDSVAKSMIKTAFETLDKALEARLAAKAGSAPVEFKAPTEAEFAAAVTKDMASGLKEVAEVRMLFYVIPLILVLVVIAYLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M4</accession>
    <name>E8N1M4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 11">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">trpE</name>
        <name evidence="14" type="ordered locus">ANT_05950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559024.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05950"/>
    <dbReference type="EnsemblBacteria" id="BAJ62629">
        <property type="protein sequence ID" value="BAJ62629"/>
        <property type="gene ID" value="ANT_05950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05950"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_0"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="13">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="12">
        <location>
            <begin position="221"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ62629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="503" mass="55860" checksum="77D3B49EBC19A3E3" modified="2011-04-05" version="1">MTQPLTHVSLPVSAKSVPAPLVRTLPADLETPVSIYLKLANGSPSFLLESVTGGEQVARYSFIGVRPRRIYRIEGDRLIVSDLQGREEYYSGEPFKQLERLFSAKKRPVLPGLPRFSGGLVGYLGYEMVRYFEAGIGTLPAQYEYPDALLLEVDTLAAFDHAFGKIILIAHPEPALPRNEAQQEAEQRLDELQASLRKPLELPLSYPSHAEMTTMKSNMSREQFLSAVEQAKEAIRAGEIFQVVLSQRFSRTTSAHPFEIYRALRRLNPSPYMFYFDFANSTAGEPLRLIGASPEMHVRLSGNTATIRPIAGTRPRGTTPEADLQLEKDLLADPKERAEHVMLVDLARNDLGRVCTYGSVQVREQMTIERYSHVMHIVSQVEGTLRPELNAFDLMRATFPAGTVSGAPKVRAMQIIRDLEPTPRGVYAGAVGYFAFDGSMDTCIAIRTLVMQGKRISVQAGAGIVADSEPEREYQETLNKARALAQAIEIAEKPEEHHVAYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M6</accession>
    <name>E8N1M6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na(+)/H(+) antiporter subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mrpG</name>
        <name evidence="3" type="ordered locus">ANT_05970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559026.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05970"/>
    <dbReference type="EnsemblBacteria" id="BAJ62631">
        <property type="protein sequence ID" value="BAJ62631"/>
        <property type="gene ID" value="ANT_05970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05970"/>
    <dbReference type="eggNOG" id="COG1320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121334_0_0_0"/>
    <dbReference type="OMA" id="MAITFAT"/>
    <dbReference type="OrthoDB" id="2051355at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005133">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34703">
        <property type="entry name" value="PTHR34703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03334">
        <property type="entry name" value="PhaG_MnhG_YufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01300">
        <property type="entry name" value="CPA3_mnhG_phaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="14982" checksum="110425D733CA4B6B" modified="2011-04-05" version="1">MNIVIVGLAFLGAFFIFLASIGILRMPDLFLRMSATAKAGTLGVGTLLFATILHFQDFVITSRALATIIFLILTAPVAAHMIARAAYFDGTPLWEGTVRDDLKNHYQLTTHALDSQVHPAEDTPSIETAEGDDFTEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P8</accession>
    <name>E8N1P8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559048.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06190"/>
    <dbReference type="EnsemblBacteria" id="BAJ62653">
        <property type="protein sequence ID" value="BAJ62653"/>
        <property type="gene ID" value="ANT_06190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06190"/>
    <dbReference type="eggNOG" id="COG2835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155659_4_2_0"/>
    <dbReference type="OrthoDB" id="1834382at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="75" mass="8604" checksum="01593774D36EF3EF" modified="2011-04-05" version="1">MVHPDLMEILRCPVCVREEGKTGLLTLSRDYWLVCQDCQRKYPIVDEIPVMLIDEGDKWIQTAVEDLPVPPPAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V3</accession>
    <name>E8N1V3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06740"/>
    <dbReference type="EnsemblBacteria" id="BAJ62708">
        <property type="protein sequence ID" value="BAJ62708"/>
        <property type="gene ID" value="ANT_06740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06740"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_0"/>
    <dbReference type="OMA" id="TREYEGI"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="45557" checksum="3256EC7F86AC424F" modified="2011-04-05" version="1">MMSVTIDERSNWKRPFFIIWIGQAFSIVGSILVQFALVWWLTRETGSATVLATATIFSMLPGIFIGPFSGALVDRWNRKTIMLVADSLIALMTAGLVLVFWMGQAQVWHVLVVMLVRALGGTFHFPAMQASTSLMVPEKHLSRVAGLNQALNGVLNIAAPPLGAFLMSLLPIYQVLAIDIVTAAIAVGTLAFIHIPQPKRRPEGVLTPQALWGDVREGFRYLAHWPGMLILLGMATLVNLLMSPAFSLMPLMITRVFKGEAMHLGVMNSAEGLGVILGGLALSVWGGFKRKVHTSMAGLVGMGLGVILLGSAPAQMFGVALLGIGIAGFMNPITNGPLFALLQAKIAPEMQGRVFNLVGALASAASPLGLMLAAPVADYLGIRFWFWIAGVSCLVMAGVALSIPAVVHLEDVSGAPRSEGRSALAVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N270</accession>
    <name>E8N270_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">mobA</name>
        <name evidence="6" type="ordered locus">ANT_29910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29910"/>
    <dbReference type="EnsemblBacteria" id="BAJ65017">
        <property type="protein sequence ID" value="BAJ65017"/>
        <property type="gene ID" value="ANT_29910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29910"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_2_1_0"/>
    <dbReference type="OMA" id="HENGYIE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ65017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="207" mass="22563" checksum="938AA0CBE27095C2" modified="2011-04-05" version="1">MNERFTVVIQAGGESRRMGEDKALLSFLGEPLIARVLRRIQPIADEIIVVARQPETLAFLGVKVVSDLLPGVGALGGLHTALAVAGNPLVGVAACDMPFVSPEILKVACRRLQESGADAVIPLLEEGWEPLHAVYRRETCLPLVERAIQRGERRLISWHSEARILPLAEDEICLLDAHLQAFLNINTPEDLRLAEALAREEEQSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A1</accession>
    <name>E8N2A1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NarL family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_30220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561389.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30220"/>
    <dbReference type="EnsemblBacteria" id="BAJ65048">
        <property type="protein sequence ID" value="BAJ65048"/>
        <property type="gene ID" value="ANT_30220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30220"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="QHENKEY"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ65048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="220" mass="24839" checksum="6F3BD56F9489352C" modified="2011-04-05" version="1">MNRIRIVIVDDHALVRMGLTTLICDRPDMQVVGEASNLTQALRVIEETQPQIVLMDIRMPGESGIEATRQIVQRFPQTRVIILTSYSDDELVMRAIHAGASGYVLKQADNDVLLDAIQTVARGESLLDPATTTRLLHFVREMERKAEQNAFRDLSERELSVLAELAKGKTNAEIGRTLHLSEKTVRNHVSVILEKLHLSNRVELATYAVEHHIFDLVKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C1</accession>
    <name>E8N2C1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559121.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06930"/>
    <dbReference type="EnsemblBacteria" id="BAJ62727">
        <property type="protein sequence ID" value="BAJ62727"/>
        <property type="gene ID" value="ANT_06930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06930"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099391_0_0_0"/>
    <dbReference type="OMA" id="FPEYCLT"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="240" mass="26885" checksum="55360BE2F4557B27" modified="2011-04-05" version="1">MMRLALIPLAIVPREKEQNIYKFECLLEYLLPKRPDLMLLPECAFTGYLYEESDLHEFAEPLDGFTITRMAHLARRHGVALAFGFLERASEGVYDSAVLLDRQGNLSMLYRKISEQAPFLCGTHAGIIETEWGKLGMLMCGDLFHEEALATLSRDMRLLLVPMSRGFDGRSPDAERWEREERSAYVEAVRQAGVPAALVNSLEQDTPEGAFGGAMLVDAEGKVLAESPHGSDMPLFVEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G1</accession>
    <name>E8N2G1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62767">
        <property type="protein sequence ID" value="BAJ62767"/>
        <property type="gene ID" value="ANT_07330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07330"/>
    <dbReference type="HOGENOM" id="CLU_2646594_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="76" mass="8729" checksum="D23ECA5B9AC2C61A" modified="2011-04-05" version="1">MINFIFSGYLLQFLQIFEMTVLGSLSPASVERGAKKQVTSWENFTTWSCSYPVIGNVMWLSMLMWVFPGPITTRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G3</accession>
    <name>E8N2G3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_07350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559162.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07350"/>
    <dbReference type="EnsemblBacteria" id="BAJ62769">
        <property type="protein sequence ID" value="BAJ62769"/>
        <property type="gene ID" value="ANT_07350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07350"/>
    <dbReference type="eggNOG" id="COG2898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_7_2_0"/>
    <dbReference type="OrthoDB" id="542304at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2_TM" evidence="9">
        <location>
            <begin position="23"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="242"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="564" mass="63640" checksum="9AD8615AB9E282D9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I4</accession>
    <name>E8N2I4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62790">
        <property type="protein sequence ID" value="BAJ62790"/>
        <property type="gene ID" value="ANT_07560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07560"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1522140_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="176" mass="19679" checksum="9334DBF775B78433" modified="2011-04-05" version="1">MPPLQKDGVMKRKSVLIIGAGIAGLSAGIYAQMNGYSSHILEMHTMAGGLCTAWKRKGYTIDGCTHWLTGSNPRDPMYTWWQEIGLVQGRTFIDFDTFAVIEDEGGRAFHMYTDVERLERHMLDLFPQDTQAVKEFIQGVRLALEMPTPDSRKKGVSALLDGIRSGFWMLTHLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J7</accession>
    <name>E8N2J7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tyrS</name>
        <name evidence="10" type="ordered locus">ANT_07690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559196.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07690"/>
    <dbReference type="EnsemblBacteria" id="BAJ62803">
        <property type="protein sequence ID" value="BAJ62803"/>
        <property type="gene ID" value="ANT_07690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07690"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_0"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="359"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="426" mass="48029" checksum="F703767312B981C8" modified="2011-04-05" version="1">MSHNAFEELQWRGLIFDYMEGVPELLAKEKVTVYNGFDPTADSLHVGHTLPLIALARLQRFGHTPIAVAGGGTGMIGDPSGKSSERQLLSREQIEYNVSCIQKQLAHLLDFEVKSNPARLVNNADWLLKLNLVDFLRDIGKHFTVNYMLAKDSVKSRIDREEGISFTEFSYMLLQSYDFLHLYDTFGCKLQTGGSDQWGNITAGAELIRRVRGGQAYGMVYHLITKADGTKFGKTESGSVWLDPNKTSPYRFYQFWLNTDDRDVVKYLKYFTFFTREEIAELEASLAERPEQREPHRALARAMTQMIHGETALARAEQASQALFGGELETLTAAEIADIFSEVPSCEVPRHQLEGEGYPLVDLLVTAGVAKSKGEARRNIQEGGIYVNNRRVEDLNRAVHLQDALQGQFVVLRKGRKNYTLVRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2M5</accession>
    <name>E8N2M5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559223.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07970"/>
    <dbReference type="EnsemblBacteria" id="BAJ62831">
        <property type="protein sequence ID" value="BAJ62831"/>
        <property type="gene ID" value="ANT_07970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07970"/>
    <dbReference type="HOGENOM" id="CLU_1700593_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="154" mass="16451" checksum="E4FB6D2127484AE4" modified="2011-04-05" version="1">MKVLKWVGKILVVLASIIVIAGAVVWVVNRGWAGAMLRAGRPALQEGYRMPRGDSDDFKRFDGAPNWNGVRPGGDFRGDFHGRRVSFGLGALRILSRLAIFALVTAGVFLAGYFLGRRKLAGSRSEPSAVSVTPPPAPAVETPSPAQKEEPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N7</accession>
    <name>E8N2N7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559235.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62843">
        <property type="protein sequence ID" value="BAJ62843"/>
        <property type="gene ID" value="ANT_08090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08090"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_0"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228098" evidence="2">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="462" mass="50351" checksum="A494B24C294B3CD1" modified="2011-04-05" version="1">MKKNLSIILTLLVLASLLLSACGTPATPTQADQPTTKPAEPTKAAEPTKAPEQPAAETTLKIYLLDYTPDTIAWLKSEINPAFEAAHPGVKVEITEGSWSGWDTTFSGFFAAGQGPDIINLGSEMNTLYGESLADMEPYLGEAAWPEIKNFGPALENAKYKGKLRGLPIFTAPRYVFCRTDLMEKAGWTTGTPKNFAEWVDFAKKATIIDPATNSLVQQALVPVDAASMADWQWWLLVFYSLGGELYKADGTPNFDSPEALATTKWMLEMRQAIYGPYANAVGSLPTGQGSVIDVNDETGKDNGAVCLAHSGWAAPAFNRPIWEKISIDPFFGDPANFPKSKPVVLAFNDWLAVPEYSPNKQLAADWLKLAFTKEANHKWNETMGLIPARNDAHYGYVTDTPQLKREAELASQYGVGFAGILESAKLSTIMQDALGKLITEELTPEEVVAKIQEEYSAALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Q6</accession>
    <name>E8N2Q6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559254.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08280"/>
    <dbReference type="EnsemblBacteria" id="BAJ62862">
        <property type="protein sequence ID" value="BAJ62862"/>
        <property type="gene ID" value="ANT_08280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08280"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_4_0"/>
    <dbReference type="OMA" id="WASHIEE"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="368" mass="40822" checksum="1E180420F6DD1157" modified="2011-04-05" version="1">MSKTVRVGVIGVGQIGKRHLDLYTKEIQGVEVVAIADINESEARRVAEMYRIPYVYTDFRKLLERDDIEAVDVCLHNNFHMPVTVAALQAGKHVYCEKPMAGAYVDALKMYRTAQETGKMLSIQLNTLFEDEAKAARALIDQGLLGHIYHARSVGFRRRGRPYVDGYGSPQFVQKAICSGGALYDLGVYHIAAMLWLIGNPRVLRISGATYQETEMDAERRAKSGYDVEELGLGLVRFEGNLTMDIFEAWAVHMDAMPGSVIFGSKAGIRLQPFGFFYSLGDLDINATADIGGFNWRLHSLRANADGYDSAQHHWVAALQGRVPLLPTAELALNTMLISEGIYLSQKRGREVTAEEVEAESISTAQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2R4</accession>
    <name>E8N2R4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561405.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30380"/>
    <dbReference type="EnsemblBacteria" id="BAJ65064">
        <property type="protein sequence ID" value="BAJ65064"/>
        <property type="gene ID" value="ANT_30380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30380"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056607_7_0_0"/>
    <dbReference type="OMA" id="NAYHDIR"/>
    <dbReference type="OrthoDB" id="1777515at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="PTHR13355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="152" mass="17720" checksum="72392DD8F872B791" modified="2011-04-05" version="1">MIIIQSPTTRDEFKAYYDLRYRVLREPWGQPRGTEKDDYEPLSQHFMAVREDTREIVGVVKLFEKEPGVGWFSHLAVAPAYQKKGIGKMLVAHVEEEARKRGFCVLGCYARLNTTNYFEKLGYRIAGLPTHYFGTTQVVWMQKDLEQPEERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S4</accession>
    <name>E8N2S4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561415.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30480"/>
    <dbReference type="EnsemblBacteria" id="BAJ65074">
        <property type="protein sequence ID" value="BAJ65074"/>
        <property type="gene ID" value="ANT_30480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30480"/>
    <dbReference type="eggNOG" id="COG2968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080344_4_1_0"/>
    <dbReference type="OMA" id="LPNGPHI"/>
    <dbReference type="OrthoDB" id="1825422at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228101" evidence="1">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="241" mass="25334" checksum="96A867A115866F49" modified="2011-04-05" version="1">MNFKRLSLFIVLLVMVALTACQATPVLAGGGGAQPQVRTLSVNGNGKVYLTPDVAYINIGVQSQSESVSDALNENSRKAQAIANALKEMGVAEKDIQTSAFNIFPQQQYDPEGKMTGILYVVDNTVNVTVRDLTVLGKLLDAAVRAGANNIYGITFDVVDKSKAITEARQLAAEDARRQAEELAGAAGVKLARVQSISSYVSSGPAPLYDAKGGAAAVGQVPISAGQMVISVDVNITYEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V5</accession>
    <name>E8N2V5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561446.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30790"/>
    <dbReference type="EnsemblBacteria" id="BAJ65105">
        <property type="protein sequence ID" value="BAJ65105"/>
        <property type="gene ID" value="ANT_30790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30790"/>
    <dbReference type="HOGENOM" id="CLU_2931019_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="60" mass="6889" checksum="F0551CB4AC1EC309" modified="2011-04-05" version="1">MEKWKDLLRSRKFWALLIGLILMVVKAYRPDFPLEEEQLSGMIALLVAYILGVALEGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z2</accession>
    <name>E8N2Z2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cheR</name>
        <name evidence="7" type="ordered locus">ANT_31160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561483.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31160"/>
    <dbReference type="EnsemblBacteria" id="BAJ65142">
        <property type="protein sequence ID" value="BAJ65142"/>
        <property type="gene ID" value="ANT_31160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31160"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_0_1_0"/>
    <dbReference type="OMA" id="DYYTAAY"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="286" mass="33348" checksum="0DEBB92994BC66CF" modified="2011-04-05" version="1">MASLLGETITLPEDLFALLSELIRQHLGLEYPPDKRSILQDRLYPLLVEEGMDSFFDLYYLLKYNGGNETLWKRVQSALAVRETYFWREVDQILAAANYLIPALQAEAPGRTVRVWHAACASGEEPYSLAMALSENGAVDWERLEIIGTDFDETSLNIARRGVYGMRSFRVLPAHLREKYFTEVQSQHFQIHEKFLKKVQFKYLNLMDEAGMQGMQDFDFIFCRNVFIYFDIPSITRTAQHFYEALRNPGYLFLGAAESLLRIPTRFELRELHRAFVYVKQEKEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N333</accession>
    <name>E8N333_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561523.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31590"/>
    <dbReference type="EnsemblBacteria" id="BAJ65183">
        <property type="protein sequence ID" value="BAJ65183"/>
        <property type="gene ID" value="ANT_31590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31590"/>
    <dbReference type="HOGENOM" id="CLU_1286551_0_0_0"/>
    <dbReference type="OrthoDB" id="1783426at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="214" mass="24353" checksum="414971062AAFF157" modified="2011-04-05" version="1">MNTNKRVFTRLSLGFSILWAFSGLASILLGWMLSWGLMLIARGIFGDYIYVNGVRHITEDYFFSWVFFPLIGLLQGGIQALILREVHPRPGLWALVTPAGWIAGFIVLRVVSEWFFTRWTSSENSPFYLLIVFFTLGVCISLAQWLVLRRWAARAGWWVLFSTLGWVILPLFSGESFSSVLELLLIGLLPSVVCLPAFWLMFDREHNGQAEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N374</accession>
    <name>E8N374_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559280.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08540"/>
    <dbReference type="EnsemblBacteria" id="BAJ62888">
        <property type="protein sequence ID" value="BAJ62888"/>
        <property type="gene ID" value="ANT_08540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08540"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_1_0_0"/>
    <dbReference type="OMA" id="AYAEFVH"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="165" mass="18488" checksum="1C928DCF6986ED16" modified="2011-04-05" version="1">MDETLKNLAEAFAGESQARNKYLAFARKAEEEGYPQVARLFRAAAEAEFIHALNHFRAMGGIGTTEENLKSAIGGENHEWVSMYPPFVEQAEREGNRRAKTSFEYAMAVEKTHEMLYREALESLSSDMEAYDYYVCPVCGHTHPRNAPEKCPVCGAPGSKFIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N384</accession>
    <name>E8N384_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_08640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559290.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08640"/>
    <dbReference type="EnsemblBacteria" id="BAJ62898">
        <property type="protein sequence ID" value="BAJ62898"/>
        <property type="gene ID" value="ANT_08640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08640"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_0"/>
    <dbReference type="OMA" id="ILTPRTQ"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="202"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="268"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="431" mass="49234" checksum="FB7F69C64C14CCEB" modified="2011-04-05" version="1">MMVSVLVAFLIGAILLDLLFSAVRGSVINARLPSLMEMGEERPEKVRDSIAVLQKPRLRTTVRVMLFWTHLFIIFLGLMLMQNLFPQARMELWLLGLVLIGLIVLFLEHLVEGGVLEHAEEWTIRFTPLARFLDGLFSPLTTPLLHLLGSPQALQQRFISVTESELRTWVKEGEPEGSLDQDEREMIYSIFHFGEKLCREIMVPRIDMSAVEIQTPLEEVIQILTRTGHSRLPVYEETVDNIIGLLYAKDLLKVRPEEGQTLESLRNILRPAYFVPEAKHVKDLLEEMQEQRIHMAIVVDEYGGVAGLVTLEDIVEEIVGEIRDEYDQSEEQPYQKISEDEYLFQARIDLDDFNEIMGTHIEKDLADTIGGLMYGLIGQVPTGGETVQIEGVLLKVEQVTGRRIRKVRATRIHPVSDEHSVHGENDHEIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F9</accession>
    <name>E8N3F9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">dtd</name>
        <name evidence="2" type="ordered locus">ANT_09390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559364.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62973">
        <property type="protein sequence ID" value="BAJ62973"/>
        <property type="gene ID" value="ANT_09390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09390"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_0"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="145" mass="15836" checksum="85F70503CEC4137A" modified="2011-04-05" version="1">MRAVLQRVKQGSVSVNGREIARIGKGLVILAGIGHQDDEKIVRAMAEKIAFLRIFEDEQGKMNLSVRDVGGEALVVSQFTLYADARKGRRPSFTDAALPEKARPLVDLFARALAEQGVPTQTGEFGAEMLVEIYNDGPVTILLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M1</accession>
    <name>E8N3M1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">fusA</name>
        <name evidence="9" type="ordered locus">ANT_10010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559426.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63035">
        <property type="protein sequence ID" value="BAJ63035"/>
        <property type="gene ID" value="ANT_10010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10010"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_0"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="EFG_V-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
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        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="entry name" value="EFG_C"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="8"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="204"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="690" mass="76366" checksum="EAEE88F4F1AF4AF9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S0</accession>
    <name>E8N3S0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559474.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63084">
        <property type="protein sequence ID" value="BAJ63084"/>
        <property type="gene ID" value="ANT_10500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10500"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_0"/>
    <dbReference type="OMA" id="DLWKGRV"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
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        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
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        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="322" mass="35743" checksum="4A59E40C379FEEE8" modified="2011-04-05" version="1">MEDLGLVAIGEILVDLIGTEPAENLDATECFCRFQGGSPANLAVNVARLGGRSALIACVGNDAFGRFLERRVAQSGVDVRWLRHEEQAPTSLVFVSRTSGTPDFQPYRGADFRITARDIPDEVIRAAQVVHITTWPLSMEPSRSAVLSAIQRAKAWGKAVSFDPNFSPKVWANHSQALEVIREVYRSVTLTKASLVDCHRLFGEGETPAEYIRRFHDWGAEIVVFTMGEQGSLLSQRGHPALRLPVRPVQVVDATGAGDAFWAGFLTAWMDGKSPRECLLFAREVVEIKLKTVGPLREGLNRWEIYARMPQPDEEFMPWHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V0</accession>
    <name>E8N3V0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559504.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10800"/>
    <dbReference type="EnsemblBacteria" id="BAJ63114">
        <property type="protein sequence ID" value="BAJ63114"/>
        <property type="gene ID" value="ANT_10800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10800"/>
    <dbReference type="eggNOG" id="COG4684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088550_1_0_0"/>
    <dbReference type="OMA" id="SIMYGPR"/>
    <dbReference type="OrthoDB" id="1466380at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="185" mass="19154" checksum="744B0A918558ADD5" modified="2011-04-05" version="1">MPEERTRKIVIAGIMSAIAIFLGVTRLGFITWFSGASLTIMHVPVIIGAILEGPVVGLVIGLIFGVSSMIQAAVAPGGPADTLFTNPLISVLPRLFIGPVAWLVWKSLKNLPVVGLIAAGVLGSLTNTILVLGMIAVVANFSPAQLLPIVVANGLPEAIGSALIVLVVVGAWLRIRVGRKQGANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N422</accession>
    <name>E8N422_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559574.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11520"/>
    <dbReference type="EnsemblBacteria" id="BAJ63186">
        <property type="protein sequence ID" value="BAJ63186"/>
        <property type="gene ID" value="ANT_11520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11520"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_0"/>
    <dbReference type="OMA" id="MTCYDVR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="262" mass="29868" checksum="3CEA2980164D92C7" modified="2011-04-05" version="1">MNPVISLAQMHIEPGNLQKNVATAFSMIEKSATRKSTIVLLPELWSSGYDLEKAETYANETPEILKDLTYLAHQYHLSIGGSLLEKSDRGIYNTFYWISPTREILAYRKIHLFRLMEEDRWLNPGDHLQMVSTEMGQAGLAICYDLRFPELFRQYALSGATIFLLSAEWPLKRIHHWQTLLRARAIENLCFLFAVNCVGPAYKDVFGGSSAIISPWGETLAEGSQTDEDLISAQIDPNQVERARGFLPVFQDRRPDLYHLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N442</accession>
    <name>E8N442_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559594.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63206">
        <property type="protein sequence ID" value="BAJ63206"/>
        <property type="gene ID" value="ANT_11720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11720"/>
    <dbReference type="eggNOG" id="ENOG5033B21">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136216_0_0_0"/>
    <dbReference type="OMA" id="YINRYAR"/>
    <dbReference type="OrthoDB" id="1587454at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="244" mass="27868" checksum="CF8BE1B41B34A49D" modified="2011-04-05" version="1">MNVLRDEKKVQRNQKIGQYTSFVALAVLVGGFVLALNQIIASFKDPAIMTTPESERYLTLSYGAMFVGLILTQISLYFGNRFGKIPLDEAITSSLKGLDDRYHLYHYQGPVSHLLIGPSGIWLLVPFYQKGFITFEKNRYRQHGVSWLARLFGQESIGRPELDAEAALMDWDKFVKKTLSDEQLPQANVVLVFTHPDVQLDRMDNAPYPAVHVEKLKDFVRKRAKQQVFPPEQIQKIIEVLPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J6</accession>
    <name>E8N4J6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13280"/>
    <dbReference type="EnsemblBacteria" id="BAJ63360">
        <property type="protein sequence ID" value="BAJ63360"/>
        <property type="gene ID" value="ANT_13280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13280"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_3_3_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="152" mass="16984" checksum="4B2DD6DA339963AA" modified="2011-04-05" version="1">MVTRLKLPGVIAQSLIERDHRVISPSYPRGYPFVMDHGKGCEVWDVDGNRFLDFAAGIAVNSTGHSHPKVVKAIQEQAEKFLHISSDFYHEGWIRLGESLNDIAPFNEPAVSFMTNSGTESVEAAIKLARYVTGRTQFIGFLGDFTDERWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4P4</accession>
    <name>E8N4P4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">atpC</name>
        <name evidence="10" type="ordered locus">ANT_13800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559792.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13800"/>
    <dbReference type="EnsemblBacteria" id="BAJ63408">
        <property type="protein sequence ID" value="BAJ63408"/>
        <property type="gene ID" value="ANT_13800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13800"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_2_0_0"/>
    <dbReference type="OMA" id="MGGFAEI"/>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="8">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="15583" checksum="98C4167ADEE5E71B" modified="2011-04-05" version="1">MPIRCEIVSQDRVVFAEDVDMVILPGGGGQMGVLPNHSPVLTTLQYGIIHVKKQGEEYYFTVAGGFAEVQPDQVTVLADAAENVEEINLQRAEEARRRAENLLKQGIPEDTDEYLNIQAALRRSNLRIEAVKRYRRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Q1</accession>
    <name>E8N4Q1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative type II/IV secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559799.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63415">
        <property type="protein sequence ID" value="BAJ63415"/>
        <property type="gene ID" value="ANT_13870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13870"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_4_3_0"/>
    <dbReference type="OMA" id="HDERVIT"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="80"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="439" mass="48185" checksum="9CA5A012B5EB4E3A" modified="2011-04-05" version="1">MNNPGAAPRQADLAKLKDYLINVVSRELESNPPPSGGEDRRKVVSQLLMQAYQTTRLQLPNSIRDQLFHDILDDLLGFGPLQPLLDDPDISEIMVNGPKLVYIERKGKLQKTNITFENDAAVIRLIEKIVLPLGRRIDADSPTVDARLPDGSRVNAVIPPCAIDGPTITIRKFQKDKLTIQQLINYGSITENMANFIRACVIARLNIIISGGTGSGKTTLLNILSSFIPEDERIVTIEDAAELKLQQEHVVRLETKPPNSEGRNAVTIRDLVRNALRMRPDRIVVGECRGGEALDMLQAMNTGHDGSLTTLHANTPRDALSRLETMCLMSGMELPVRVIREQIASAIDLIIQVARLKDGSRKVVSITEVAGMEGDTIVMTDIFKFEQTGISTDGKVLGELKPTGIRPLFTPRLEAAGFKLGPEVFGANLADILGGGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Q5</accession>
    <name>E8N4Q5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559803.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63419">
        <property type="protein sequence ID" value="BAJ63419"/>
        <property type="gene ID" value="ANT_13910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13910"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_31_0"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="104" mass="11147" checksum="1282DFE354020B92" modified="2011-04-05" version="1">MQLVDNAIKFTPPAGKVHLFTERDEGFLKIQVSDTGIGIPADRIEQIFEPFVQLDGSSTRKAGGTGLGLALARRIIEAHGSVIHVHSEESKGSTFSFALKIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R1</accession>
    <name>E8N4R1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">parB</name>
        <name evidence="5" type="ordered locus">ANT_13970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559807.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63425">
        <property type="protein sequence ID" value="BAJ63425"/>
        <property type="gene ID" value="ANT_13970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13970"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_0"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="284" mass="31626" checksum="A93A14E93D363D61" modified="2011-04-05" version="1">MARKGGLGKGLGALIPGESPQSEGGVISLPIHQIKPNPRQPRTEINEAHLQELAESIREHGVLQPVLVTTEPGKDGYYLVAGERRLRAAQMAGLELIPAIIRSVSEQERLELALIENLQREDLSPLETAEAYQKLVEEFGLRHEDIAIRVGKSREAVSNTLRLLNLSAEVKKALQSGQISEGHARALLGLPHEAAQNALLKVILEQGLTVRQTEELVRKMSGERPQKRRKRGLSPELQEYEEQLRSRFGTKVSIRHGQKGGAIVIYYFSEEEFDHLLHQFLGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R8</accession>
    <name>E8N4R8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63432">
        <property type="protein sequence ID" value="BAJ63432"/>
        <property type="gene ID" value="ANT_14040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14040"/>
    <dbReference type="HOGENOM" id="CLU_2353739_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="96" mass="10867" checksum="80EC0C7E054DAE2A" modified="2011-04-05" version="1">MPDCFSFLAWNIIEIYWNGGGFMENLPLSDFWDAILSRNPRLIREAFVGLDESSKTAVMAHLEKMATESGWHPEQVKSAKAALVVIHGMNVKTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U9</accession>
    <name>E8N4U9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559845.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63463">
        <property type="protein sequence ID" value="BAJ63463"/>
        <property type="gene ID" value="ANT_14350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14350"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_1_0"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="148" mass="16266" checksum="3FFA5541433409D8" modified="2011-04-05" version="1">MLSRQSIEQALKEAMRSNDEVARRTLRMILSAIKLAEVEKGASLDETALVAVLQKELKSRRESIADAEKANRPDLAEAAKAEIAVIESFLPKQLTLEELEQIAREAILEANATTPADMGKVMKILMPKVQGRAAGDQVSQMVRKLLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X4</accession>
    <name>E8N4X4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559870.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14600"/>
    <dbReference type="EnsemblBacteria" id="BAJ63488">
        <property type="protein sequence ID" value="BAJ63488"/>
        <property type="gene ID" value="ANT_14600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14600"/>
    <dbReference type="HOGENOM" id="CLU_344094_0_0_0"/>
    <dbReference type="OrthoDB" id="619654at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228178" description="CBM20 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="232"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="822" mass="92128" checksum="188319BC5551CCAF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y9</accession>
    <name>E8N4Y9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559885.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14750"/>
    <dbReference type="EnsemblBacteria" id="BAJ63503">
        <property type="protein sequence ID" value="BAJ63503"/>
        <property type="gene ID" value="ANT_14750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14750"/>
    <dbReference type="HOGENOM" id="CLU_2448206_0_0_0"/>
    <dbReference type="OrthoDB" id="2217332at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="89" mass="9745" checksum="C9627CC315F2AC24" modified="2011-04-05" version="1">MTLPALLFGFLVATLMGAAFHLWKNGGLGRLILYLLLAWIGFWTGHIVANALGWHFLSVGPLRFGMAVLSALLFLGVGHWLSLVKNEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N516</accession>
    <name>E8N516_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_15020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559912.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15020"/>
    <dbReference type="EnsemblBacteria" id="BAJ63530">
        <property type="protein sequence ID" value="BAJ63530"/>
        <property type="gene ID" value="ANT_15020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15020"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_0"/>
    <dbReference type="OMA" id="NSPNWFA"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="449" mass="49247" checksum="16CE244B74B5C3F6" modified="2011-04-05" version="1">MGKHKHSGRTLFALGLGYLVDQGEGQSMGVLSPIIQSIWGITFQQIGIMETLRSIAQTVSAPFWGYVSDKFSRKKVLIFGTGVWGIWTVLVGLVPNFYSMLLIRAISGLGLGCLMPATFSLLGDHYPQNQRGRALGVIGLVGLMGTVLGVLALGFVASPELWRWGFIGLGLASILSGIIIWLLVEEPPRGSAEPELAGLITHDDEKEYSINWKDMFNTLRIPTIWAAILQGITGSMPWVVMGIYFINWMVRELGYSNDISFSDPKGSAPLVFAGVVVSAAISNLLGGFIGDFAEKVNPKYGRTVIGQFSVFVGVPLMYILLTQAKNWSFIQLFIFASVTALLIGWPGRGAKEPMMQAVVPPEMRSSAYSIVNLIEGGLSAFASYIAGSLADQIGLTNALLWTIPFPWVICGLLFSIFYFTYPRDAEKVRRMMEQRRDELIQKRQAVAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N527</accession>
    <name>E8N527_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559923.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15130"/>
    <dbReference type="EnsemblBacteria" id="BAJ63541">
        <property type="protein sequence ID" value="BAJ63541"/>
        <property type="gene ID" value="ANT_15130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15130"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101290_0_0_0"/>
    <dbReference type="OMA" id="GDEIMCG"/>
    <dbReference type="OrthoDB" id="1632705at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="18847" checksum="1EA3B0FF2D01694C" modified="2011-04-05" version="1">MIKCPNCHHEELPGSLYCSECGAQLVVSQTTTTQHIQRNPSDVLVVTPPTQTPSKPGIYPEGEAEFKVLLSFVDSGKVIELSGQNEYTLGRTSEGQPILPDIDLSPYDAYSKGVSRLHAALKIQSHRVVITDLGSSNGTRVNGQKIVPHVDYPLNHGDMISLGKFALQILIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N529</accession>
    <name>E8N529_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559925.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63543">
        <property type="protein sequence ID" value="BAJ63543"/>
        <property type="gene ID" value="ANT_15150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15150"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_4_1_0"/>
    <dbReference type="OMA" id="MLNAQFF"/>
    <dbReference type="OrthoDB" id="1835483at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="303" mass="32489" checksum="81DC5F04E94D405E" modified="2011-04-05" version="1">MLDFFKKLFGKKQIEPTKPVAMVGIETAPLSEEQLQSVLPEMVHISPPQYQVGMGISVGRQREVNEDTIFALSATIADGVRDLPFGVFVLADGMGGHASGEVASAAAAKTMAQFILNKISPLMLSVELEGAGESIQEMMENGVREAHRAVLKAAPGGGTTLTAVLALGEQITIAHVGDSRVYFVYPDGRVQVKTQDHSLVHRLKELGQITDKEASSHPQRNILYRALGQSEPFRPDIITCEFPHPGSLLICSDGLWGVLPEESIAHIVNTSKNPAQACQTLVESANIAGGPDNISVILAQYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N535</accession>
    <name>E8N535_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_15210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15210"/>
    <dbReference type="EnsemblBacteria" id="BAJ63549">
        <property type="protein sequence ID" value="BAJ63549"/>
        <property type="gene ID" value="ANT_15210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15210"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_0"/>
    <dbReference type="OMA" id="MHAWTSS"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="365" mass="40518" checksum="2C2448B65385093D" modified="2011-04-05" version="1">MGTVNSTTTPMLQNRYALEETIGSGGMAVVYRARDRMLERTVAIKLLRPKYSGNQAFQDQFRREARAAANLSHPNIVTIYDIGYDAGRLFIVMEYIEGQNLKDLIRQKGLFEVHEALPLMIQAAKGVGYAHRAGVIHCDVKPHNMLVTKDGHLKVTDFGIARAIASIHPDETTDEIWGSPQYFSPEQASGQPPMPYSDVYSLGVVFYEMLTGQLPYSGKTPADLARQHRDPNIRPIPPRHLNREIPEELEKILLLLLSKEPRQRYRNADILARILEGLDTPIAQNRVVSTSARSASVSSHTRQQPVGKENAPQQTKGSPSAVLHPTPSSTLLTPDIIVLAIIALVLGVGLLPFYSYILNVLGWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N585</accession>
    <name>E8N585_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559980.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63599">
        <property type="protein sequence ID" value="BAJ63599"/>
        <property type="gene ID" value="ANT_15710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15710"/>
    <dbReference type="HOGENOM" id="CLU_482871_0_0_0"/>
    <dbReference type="OrthoDB" id="2108341at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="564" mass="61798" checksum="E899413D26409EE7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I5</accession>
    <name>E8N5I5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560078.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63699">
        <property type="protein sequence ID" value="BAJ63699"/>
        <property type="gene ID" value="ANT_16730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16730"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102167_0_0_0"/>
    <dbReference type="OMA" id="HDYLYTY"/>
    <dbReference type="OrthoDB" id="1357188at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039248">
        <property type="entry name" value="Ptase_RsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35801">
        <property type="entry name" value="PTHR35801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="240" mass="25811" checksum="6E9FA57050043DAC" modified="2011-04-05" version="1">MEIQIAVAKTNKYAVSESGDTLEVIERPNGGVSVVLADGQTSGKAAKAISSMVVRKVIALLAEGVRDGAAARAASDYLYTEKNGKVSATLNILSADLQTNTIVIARNNHCPIYVARGEMIETLISEAPAIGTSRNIRPDISEIPLEGGTTVVMFTDGVLHAGERYGESLDIPTILGSFLEDQEPPAQVIADSLLAQAIQLDQNRPNDDMSVVVLRVLHHKQDLIRRMIVRLPVGPDENEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L6</accession>
    <name>E8N5L6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosidase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560109.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63730">
        <property type="protein sequence ID" value="BAJ63730"/>
        <property type="gene ID" value="ANT_17040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17040"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043801_0_0_0"/>
    <dbReference type="OMA" id="FLAESYW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="79"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="469" mass="54451" checksum="74B91B72A9468ADD" modified="2011-04-05" version="1">MKPLPPKPLLYEINTAIWLEELSHKTGKKITLSTIPEEEWDRLRNFGFHMVWLMGVWKRSPMGTQIALQNTGLTKEFQQVLPDYTPSDVIGSPYCVQAYQVDDRFGGKEGILKARNALHARGMKLILDFVPNHIAPGHTWTEHHPEYFVQGTENHLRKFPDAYIRIGKHIFARGKALNFPAWQDVVQLNACHPGLRKAMIETLVEIGNLCDGLRVDMAMLMLNSIFQHTWRTHGIIPPEKDFWEEVIPAVKKEHPHLFFMAEAYWDTEPVLLEQGFDACYDKRLYDYLRDRSPKLIRQQLSRSSDFQNHLVCFIENHDEKRAITAFPYNQWKLAALVTASTPGTFMLHEGQLEGRSTRIPVFLGRRPEENTSQEVAEFYTRLLALLERTELSGTFQLLPSPHPVLCGWRWQFQNQSLVFWCNPTRRVAYLKDDIVPLYNPFWAEGFVPQGNKQGHYAFQPFGFAVWEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N7</accession>
    <name>E8N5N7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ordered locus">ANT_17250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63751">
        <property type="protein sequence ID" value="BAJ63751"/>
        <property type="gene ID" value="ANT_17250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17250"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_0"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="21"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="324" mass="34971" checksum="E18AE65DB129FBB7" modified="2011-04-05" version="1">MDFNLMNLTSHAEDEKEHHPYKVVILGSGPAGLAAALYAARAELNPLVLTGMELGGQAALTHTIENYPGFPEGVGGSQLGELFQKQAERFGARVEFDIASRVDLSKRPFVIETESGQEIKAQTLIIATGASPNHLNVPGEKELTGKGVSYCATCDGWFFKDKEVVVVGGGDSALEEGIFLTRYATKVTIIHRRDTLRAGAILQSRARSNPKIQFIWNTVVTEILGEDAVKAVRLKNVVTGEESTFSTDGVFIFIGHKPNTQLFHGQLEMDEGGYIITDKKMQTSVPGVYAAGEAADPIYRQVITSAGMGAAAAMQAAKFLEEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P0</accession>
    <name>E8N5P0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17280"/>
    <dbReference type="EnsemblBacteria" id="BAJ63754">
        <property type="protein sequence ID" value="BAJ63754"/>
        <property type="gene ID" value="ANT_17280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17280"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="EAQVMAM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="261" mass="27975" checksum="DCF16FE9DD2EA14D" modified="2011-04-05" version="1">MLKMSVTLPFLEKNILVTGSGRGIGRAIALRFAELGANVVINYHRNETPAQEVANQIREMGRKVLVIRANLAKPEDIDLLFDSIEQEWGSLDGFISNAASGFNRPALQQKVTGWDWTMNVNARAFLFATQRAVPLMEKRGGGSIVAISSPGSHRVLPDYVAVGASKAALEALTRYLAVELAPKNIVVNAVAPGLVLTDALQHFASLSNPETIPHAIAQTPAGRLVTPEDVAGVVAFLCSPEAFMIRGQVIILDGGYTLPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P6</accession>
    <name>E8N5P6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560138.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63760">
        <property type="protein sequence ID" value="BAJ63760"/>
        <property type="gene ID" value="ANT_17340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17340"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018719_1_0_0"/>
    <dbReference type="OMA" id="WLPEMAV"/>
    <dbReference type="OrthoDB" id="360776at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021923">
        <property type="entry name" value="DUF3536"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12055">
        <property type="entry name" value="DUF3536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="97"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="473" mass="54675" checksum="C4F1C4C1BFD17479" modified="2011-04-05" version="1">MKPLYLCIHAHFYQPPREDPLTGEIPVEPGATPFRNWNERIHAQCYYPNAILHNYEKISFNIGPTLMEWMFDYDPITLKRIIQQAQTNVERYGVSNAMAQSYHHTILPLATRLDKITQVRWGMYDYEMRFGYPPKGMWLPETAVDLETLEVLAENGIEFTILAPWQGKDIPVSPTHPYRVALPNGKAISVFFYDQSISTRLSFDPGATVNADTFVQEFLLPKVGWINQNGGAPTLTLLASDGELYGHHQAFRDKFLAYLVNGAIQDKPIELIYPARWLKEFPPTETVEIIEPSSWSCHHGVLRWAGECPCTPNASWKAPLREAFNEIAETIDKIYLEVVGEGGNNPWELRHQYIRVVFGEISLDVLYEQVMGKPLDVSLRDELYLLLRAQYERQRMFTSCGWFFDDFDRIEPKNNVAYAAQALWLTQLVYGRDLTQVAREKLRHVKSWRTGLTADEVFVKHLQRAQDFWKVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q9</accession>
    <name>E8N5Q9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63773">
        <property type="protein sequence ID" value="BAJ63773"/>
        <property type="gene ID" value="ANT_17470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17470"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_345698_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="817" mass="93293" checksum="1A230569646D9E41" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S3</accession>
    <name>E8N5S3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17610"/>
    <dbReference type="EnsemblBacteria" id="BAJ63787">
        <property type="protein sequence ID" value="BAJ63787"/>
        <property type="gene ID" value="ANT_17610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17610"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_4_2_0"/>
    <dbReference type="OMA" id="HQKPIGL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="196" mass="21690" checksum="05002CEF750802FC" modified="2011-04-05" version="1">MLKNSIQFLCIYSGSADHIKPAYLEAAYQTGQILAQSGITLVYGGGKTGLMGAVAEGALKAGGKVIGVVPEHLNKPSLIHDGLSQLIITPDMHTRKAEMSRLANAFISLPGGFGTMEEFFETLTWAQIGLHQKPIGLLNTSGYYSPLLRWISHALQEGFIYPEHMDLFVEDEDPQKLILKLTQFKIPHNLNRWVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V0</accession>
    <name>E8N5V0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase formation protein HypD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypD</name>
        <name evidence="3" type="ordered locus">ANT_17880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560192.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63814">
        <property type="protein sequence ID" value="BAJ63814"/>
        <property type="gene ID" value="ANT_17880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17880"/>
    <dbReference type="eggNOG" id="COG0409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048562_1_0_0"/>
    <dbReference type="OMA" id="HVCGSHE"/>
    <dbReference type="OrthoDB" id="666873at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="365" mass="40383" checksum="197E5FEB55220F1C" modified="2011-04-05" version="1">MSEINLPFRDHHLIGKIVKQIQRTVSKPWVLMEICGGQTHAILRYGIDQVLPPQIELVHGPGCPVCVTPLEQIDKALMIASQKGVIFTSFGDMLRVPGSSDDLFSVRARGGDVRVVYSPIDAVRIAQENPDKQVVFFAIGFETTAPANAAAVLQAQAQNLKNFSLLVSQVRVPPAMHVILSSPQNRIQGFLAAGHVCSVMGYWEYEPIAEKYQVPIVVTGFEPADILLGILKTVELLENGKAEVYNAYPRAVRREGNQPAQRMIEQVFMPVDRNWRGIGLIPQSGWGLRTEYREYDAEDRFQVGHIQTHESPLCIAGEILQGVKKPHQCSAFGTQCTPEHPLGAPMVSAEGACSAFYRYSRVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5X0</accession>
    <name>E8N5X0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transketolase</fullName>
            <ecNumber evidence="3 8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tkt</name>
        <name evidence="10" type="ordered locus">ANT_18080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560212.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18080"/>
    <dbReference type="EnsemblBacteria" id="BAJ63834">
        <property type="protein sequence ID" value="BAJ63834"/>
        <property type="gene ID" value="ANT_18080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18080"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_0"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="670" mass="73556" checksum="BF7235CC69A0CE29" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D7</accession>
    <name>E8N6D7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AhpC-TSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19750"/>
    <dbReference type="EnsemblBacteria" id="BAJ64001">
        <property type="protein sequence ID" value="BAJ64001"/>
        <property type="gene ID" value="ANT_19750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19750"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3211697_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="44" mass="5012" checksum="EFC4AEB1E40327A7" modified="2011-04-05" version="1">MGGRLLHLMEAPDFELTDTQGNLIRLSDYRGRKPVVLVLLRGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D8</accession>
    <name>E8N6D8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64002">
        <property type="protein sequence ID" value="BAJ64002"/>
        <property type="gene ID" value="ANT_19760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19760"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_0"/>
    <dbReference type="OMA" id="HFRCLVL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="71"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="36945" checksum="555334DA1F6E9567" modified="2011-04-05" version="1">MKKLLAFLKIIGIILIVLLVGLVTIPLLIPIPPLQDIRPVQELQDQDSRFMEIQGIRVHYKIYGSGEPAMILLHGFGASTFSWREVMQPLAKYGTVIAYDRPAFGLTSRPLPGDWQGVNPYSVEGNIALLLELMNRLNIQQAILIGNSAGGRLAMQMALAHPDRVVGLVLVDAAIYQGGGVQSSLMRFLMNTPQFNRVGPYLMRSAFAGQQGQSLISMAWHNPARITPEIIEGYRKPLHMENWDRALWEFTKAGSGNEDLSLRFAELTLPVLVVTGDDDRIVPTDLSLKLAEQIPNARLVVFSNCGHVPQEECPDQFLQATEDFVHQISLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6F5</accession>
    <name>E8N6F5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560390.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64019">
        <property type="protein sequence ID" value="BAJ64019"/>
        <property type="gene ID" value="ANT_19930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19930"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053482_0_0_0"/>
    <dbReference type="OMA" id="QIELAYA"/>
    <dbReference type="OrthoDB" id="1105009at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="340" mass="39094" checksum="6164482BF782FF23" modified="2011-04-05" version="1">MARKPIPFDRVIKALLDENTPFSPTYLHRFSDLEEEELDALKQVWDQIQPTRRLALLSDLEEISDADTLVFFDNVARIALNDEHGAIRAQAIRLLWLSEDAALIPLYLNFLSDPEAEVRAEAAGALGKFVYLGELEELPEKTLHEIENRLIDVVRGKDQALVRRRALEALGFSSREEVPLLIREAYQTNDPDWVASALMAMGRSYDKEYEPEVKRMLKHPKVNVQLEAIRAAGELELESARRPLLDLLEEEAQDSEVRYAAIWALSQIGGEQVRETLEKIAEETEDDEELEIVEQALDNLQLNEEISMMMFDFDIEDEEDLKKFGRQIDLSKPEEEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF5</accession>
    <name>E8MXF5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_20100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20100"/>
    <dbReference type="EnsemblBacteria" id="BAJ64036">
        <property type="protein sequence ID" value="BAJ64036"/>
        <property type="gene ID" value="ANT_20100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20100"/>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603627_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="DUF362" evidence="3">
        <location>
            <begin position="152"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="435" mass="47751" checksum="00D11B5FF6B841CA" modified="2011-04-05" version="1">MFSRHPRRYDMVKKISRRKFLALISTGAISTWIGITHLRDQLVHGQSSSFDTFIPIILKPNQPTVTPTPSPPPTPTSTPKVTQPPPASARVVHVRHTSVTNWTGSPYAYWNYVNQTKVNLMVEQGLKTLTGQSNLVNAWQVLLPNYVQGEGIAIKVNFNNAMQMACGNETGQINALPQLVIALIGGLKARGVAESDIKIYDGVNRIFPLYFINAIHSQYPNVQLFHACADDSHKVTYNSSNPSATVQFSPPSGVPSPAPQKIADVLVNATYLINIPIMKNHSCAGITLAFKNHFGTISNPGGVHSHVFFIDGCGGGVYSNYSPLVDIYKNSNIRNKTILTVGDGIFGCLGSEDGYPSFWINTFGQGEFPKSLFFSRDPVAIDSVMADFLRAEYGYFDGSDKYLQFAQDAGLGTYERGDPWGSGYSRIDYQKIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK4</accession>
    <name>E8MXK4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560455.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64085">
        <property type="protein sequence ID" value="BAJ64085"/>
        <property type="gene ID" value="ANT_20590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20590"/>
    <dbReference type="eggNOG" id="COG4260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037108_1_0_0"/>
    <dbReference type="OMA" id="AEVYFVN"/>
    <dbReference type="OrthoDB" id="886332at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band_7_1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="299"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="347" mass="37128" checksum="C57496276F1BA117" modified="2011-04-05" version="1">MARIFDVVEYPNEMLDEIVHRFPEQGVADLRFGSQVIVRESQRAVFFRDGHALDVLGPGRHTISTANVPLLAELLGKAFNNRTPFTAEVYFVSMREFVDKKWGTPQPILVRNPGMGLGVALLQSFGTYSFQVRDPQQFVTQVVGAQHMYTTAEIENRLRTMLLSKLQDILGETAAQHTVADLIALTEEIGAAVRAKAQDDFAAVGLTLKSFYIASLKPSEKSAEELRAMGMLDMQTYTQLQAADALRDAAQNPSGGAGLTAGIGAGMGIGNMLSNTLQGSAGTGAAAASGQATPVIPDVMTPAEAAAILKVSEEDVLAAITAGDLKARKIGNAYRISREALEAFLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP7</accession>
    <name>E8MXP7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560498.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21020"/>
    <dbReference type="EnsemblBacteria" id="BAJ64128">
        <property type="protein sequence ID" value="BAJ64128"/>
        <property type="gene ID" value="ANT_21020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21020"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_0_2_0"/>
    <dbReference type="OMA" id="GHTSFNW"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="15"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="174"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="313" mass="33911" checksum="32AC18628EE63C98" modified="2011-04-05" version="1">MTSLHKPFTEFRLPPYLVLVIGVFCVSTASILIRLVQNEASALTIAAYRMVLSVLILFPLAWQKREEWLSLPHSSLKFIGLGGIFLALHFAFWISSLRFTSVTSSVVLVTTTPLWVALVSPLVLKEHPSARTWAGLTIGITGGVIVSLAQGCTWQAWALSCPDFASFFQGKAFLGNIMALIGAWMASGYMVVGRKVRAGLSLISYVFMVYAVSAFVLLIFAILAQEKILGFSPLTYVYLLGLAIIPQLLGHSSYNYALGYLPAAFVALTILLEPIGASLLAMAILREFPNTLEILGGLIILLGVGLTSLPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ9</accession>
    <name>E8MXQ9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_21140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560510.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21140"/>
    <dbReference type="EnsemblBacteria" id="BAJ64140">
        <property type="protein sequence ID" value="BAJ64140"/>
        <property type="gene ID" value="ANT_21140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21140"/>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058185_0_0_0"/>
    <dbReference type="OMA" id="MGKDAWW"/>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="444" mass="48488" checksum="B2A2C1F729C8557C" modified="2011-04-05" version="1">MGSILSYLSTLLWSGWTSLLDYLAAHVLLCLVPAFFIAGFMSSMIPKEAITRFLGPRASKWVSYPISAIGGFILAVCSCTILPLFAGIWKRGAGLGPAITFLFVGPAINILALSYTGAAIGFDIAASRLILSIGFGILIGVIMAWVFRKEERARAVEMQENGVFDQTARVKPSIWVMFALLVGILIVGTLQINVLTRVYARIELPFEWSNLLGQGLASLSLTFQGGVLILLLMVIGVTSWKGFENIFEGFNRWTYAALLLIGLTILIAAPKEEVDSLIIGINGRLIGEILLLAGVIFVARRYFTKDELTGWIWETWKFVKQIFPLLIVGVFVAGMAKVIIPETWVRTIAGQNTLLANTVGVLFGVFMYFPTLVEVPVAKMFLDLGMARGPLLAYLLADPELSLQSILVLNEVMGKKKTAVYVSLVAVLSTLAGYLFGVFIAHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU4</accession>
    <name>E8MXU4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560545.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21490"/>
    <dbReference type="EnsemblBacteria" id="BAJ64175">
        <property type="protein sequence ID" value="BAJ64175"/>
        <property type="gene ID" value="ANT_21490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21490"/>
    <dbReference type="HOGENOM" id="CLU_2821696_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="66" mass="7978" checksum="89E284CDFB94E224" modified="2011-04-05" version="1">MGEEELTHLLERLRERRLFDEVFVLILEREPQGDWKLLDYGMREISDIAAWLAVQKQKYTNEKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV8</accession>
    <name>E8MXV8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560559.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64189">
        <property type="protein sequence ID" value="BAJ64189"/>
        <property type="gene ID" value="ANT_21630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21630"/>
    <dbReference type="HOGENOM" id="CLU_2314292_0_0_0"/>
    <dbReference type="OrthoDB" id="2225283at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="99" mass="11838" checksum="2B1D1CAE78664E96" modified="2011-04-05" version="1">MATQLIRAQVMLDPEDYRRLQALANEAGKSLSETLREAVLRFLDEQERQKQEQLRKALAEMRQIREQNAARYGVYKGDLVNEAREERERQMEDVWKQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY20</accession>
    <name>E8MY20_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22250"/>
    <dbReference type="EnsemblBacteria" id="BAJ64251">
        <property type="protein sequence ID" value="BAJ64251"/>
        <property type="gene ID" value="ANT_22250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22250"/>
    <dbReference type="eggNOG" id="ENOG502ZJIW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828068_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="284" mass="30969" checksum="37C02E1BE6D831AA" modified="2011-04-05" version="1">MVIIRGDWSKNMKKILAIFFVFILGLSACNLPVSPAESPTPTVDLIATQVSILMTQQPTPTLPPTDTAPPAQTPTSMPSPTLPAPSPTPVPGDPALALGAPFWQDNLDTAKNFYLYENDNTKIEEEEGSIALVGRNANGWHGWTLTYAAPAVNLYVEEVFRTRDCAGNDLYGIVFRASKENSAYFFGVTCDGRYNLYARDFNNNVNAELVSLTADPAILSGSNQTNRLGVMAKGNTLRLYANGVLLKEIDDATYSAPYFGAFVAANQTANFRVDLDQISMWKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY25</accession>
    <name>E8MY25_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Baseplate_J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560624.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64256">
        <property type="protein sequence ID" value="BAJ64256"/>
        <property type="gene ID" value="ANT_22300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22300"/>
    <dbReference type="eggNOG" id="COG3299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543641_0_0_0"/>
    <dbReference type="OrthoDB" id="1656613at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Baseplate_J" evidence="2">
        <location>
            <begin position="214"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="501" mass="55087" checksum="AE7E680F9C832D41" modified="2011-04-05" version="1">MKTYIIQLEAYDDVISARDKISWNKSPRVLLVFPPKGSPIERPLDLLILQRYTQSLGATLGIVSRSPTVVQHAEELGIPCFSNALQAQRGSWRRTRGRRRLPFRVNKERPRILPQEYRQTQKELHTLPALPVWQRIGVFLAAILSILALIAVFVPSAQVVVPIPQQEQSLIFETRAVPDSNLELSTGVLPAQKVETVVEGNLEVPSTGRATLPENPAIGEVEFRNLTEQEVTIPAGSTVLSGGNPPVAFQTLGTVTLPAGIGQKRSIGIRAVIPGSAGNLPAGAILALEGSTGLLVTVTNPQPTKGGSDQLVPAPTLWDYEQAREKLLVLLKETARKDVAFQMSDGQIFLEGSLHPVEVIEEIREPEASTPGDFARLTLRVRFAGLSVQQTDLSALCQAILDLNLPEGYQVVDGTLVCQQENTASLATDGSVKMNLTARRRIELVWSSQTIARQILGQPLETAKQTIRNALNLERDPEIVLMPQWWGRLPFFPFRIQVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY47</accession>
    <name>E8MY47_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22520"/>
    <dbReference type="EnsemblBacteria" id="BAJ64278">
        <property type="protein sequence ID" value="BAJ64278"/>
        <property type="gene ID" value="ANT_22520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22520"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_2_0"/>
    <dbReference type="OMA" id="WYTTRER"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="259"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="638" mass="72519" checksum="B9AAD9704D2F3982" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY52</accession>
    <name>E8MY52_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_22570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560651.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64283">
        <property type="protein sequence ID" value="BAJ64283"/>
        <property type="gene ID" value="ANT_22570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22570"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075280_0_0_0"/>
    <dbReference type="OMA" id="WFGECAA"/>
    <dbReference type="OrthoDB" id="1819626at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="36714" checksum="7E8F45353D09E6B4" modified="2011-04-05" version="1">MSVTNRSLFRSLLPGVFLGFVVLLGLAFLGDLQHVSSTILEFKVQYFGIALAFTLLNYALRFVKWHIYLKQIGVHRLKIGTSLRIFVAGFPLAVTPGKVGEVLKGVWLMRKTSVPVGRGVSVVLAERLSDGLAVALLSTIGILAFPQYWIGFAILLAGLIGVMILSQIRPAALWVLDQIERVGFLRRFSQNIREFYEGSFTLFQPGVAILAVGLGLISWLGEGIGFYFILRGLGLEPTSHLLHTAVFILAFSTIIGAVSALPGGLGAAEISIAGLLTLTLHLSPDIASTATVLIRLATLWFGVFLGVITWSFSPDLTGLEMAKRLIIEPNTQPEKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE0</accession>
    <name>E8MYE0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="synonym">ppnK</name>
        <name evidence="6" type="ordered locus">ANT_00510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558483.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62085">
        <property type="protein sequence ID" value="BAJ62085"/>
        <property type="gene ID" value="ANT_00510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00510"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_1_0"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="294" mass="32119" checksum="06FB01F08FA0A1B3" modified="2011-04-05" version="1">MDSHSHPVPQRILILAYPATPGALEQVEPLMTYLKDAGVPQVAGGSFLDKDLLERLQAKDFDLLIALGGDGTMLRAGHLCAPLGIPVLGINMGRVGFLTEIRKEEWQQGMDLLLQGRYRLEERMMLKAELWRGETSLGSWLVLNEVVVCRGRFVRPIRVQACVDGYTLTTYVADGVIAATPTGSTAYALAAGGPIMPPELRNILLIPVAPHLSMDRAIILSQGACVELRVQTDAEHEAVVSVDGHSPLPLENGDQVSVQSSDLTVHFVRFEDPGYFYRNITAYMEQNPSTGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYL6</accession>
    <name>E8MYL6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_23260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560719.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64352">
        <property type="protein sequence ID" value="BAJ64352"/>
        <property type="gene ID" value="ANT_23260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23260"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775993_0_0_0"/>
    <dbReference type="OMA" id="CSFNTCT"/>
    <dbReference type="OrthoDB" id="1398158at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="148"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="405" mass="45864" checksum="8B6EBEF707BB1BBB" modified="2011-04-05" version="1">MVILTRWRGQSLTISTKPNCLTLSLQSGRDTQVYSFDGEGRFWTGIVQNISYRRGLDGKIVAKWQEGNSQRERRWLSQVEAQTLQENARRFCADLLAHLQTGQVLLNPPLDETGWTFLTRAAAFTPERYRQDIDHYHAVYRPVGILPPDQYMAVVLQAAEGCSFNTCTFCNFYRDRPFRIKTPEMFREHMKAVRDFLGEGLSLRRTIFLGDANALVIPMPRLVPLMEAIHEQFDVEQLGGIYAFLDGFSAEKKTPADYARLRELGLQRVYIGMESGNDELLRFLKKPGTAEDVVQAVQAIKRGGVAVGIILLLGAGGHQFSAQHVADSIRALQAMPLDADDLIYFSELVEDEGMQYTRDAYQANLRPLTPEERIAQGEAIEQALSFSEEGGTPHISRYDIREFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYR0</accession>
    <name>E8MYR0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hisF</name>
        <name evidence="11" type="ordered locus">ANT_23700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560762.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64396">
        <property type="protein sequence ID" value="BAJ64396"/>
        <property type="gene ID" value="ANT_23700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23700"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_0"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="OrthoDB" id="1522718at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="259" mass="27679" checksum="B7676D6E834AA9B2" modified="2011-04-05" version="1">MLAKRIIPCMDIANGRIVKGVNFVNLRDAGDPVEQAQIYDQAGADELAFLDISATQEGRETVLEMVRRVADVVFLPFTVGGGIRTVEDVRRILLAGADKVSINSAAVRNPDLLSECAERFGSQCVVLAVDARRVNPLEGSPRWEVVIHGGRIPTGRDVLEWVVEGVQRGAGEILLTSMDADGTLRGFDLELTRAVAEAVSVPVIASGGAGAVEHFAQVLTAGKADAALAASLFHEGRLRIPDLKQALWEQGIPVRRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYR6</accession>
    <name>E8MYR6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">hisG</name>
        <name evidence="14" type="ordered locus">ANT_23760</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64402">
        <property type="protein sequence ID" value="BAJ64402"/>
        <property type="gene ID" value="ANT_23760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23760"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_0_0_0"/>
    <dbReference type="OMA" id="LDIHNTR"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="58"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="235"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ64402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="336" mass="36551" checksum="83165BAFA9FA2326" modified="2011-04-05" version="1">MVQPLQNLVRLSLPSKGRLAEDALAFLQACGLSVYKPNPRQYEATIPSLPGLTVLFQRPADIVVSVRDGSVDFGITGIDVIEERRGENGSLMVLHESLGFGACALCLAVPEIWNGVDSVARLRQYVEELGRPLRVATKYPVLTGRFLRNAGIPHVLISAEGTLETAPAIGYADIISDLVSSGQTLRDNRLRPLTDGVIQPSQAALIANRASLQRSPEALQIARQLLEYIEAYLRARDEVAIFANMRGTSPEELATRIFTQPTIAGLQGPTISRVIVRSGDPNWYAVNVIVPRSRLFQAISELRAVGGSGVVVVPVNYIFEEEPPRYTAMLKALAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ81</accession>
    <name>E8MZ81_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="3">SDH</shortName>
            <ecNumber evidence="3">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">aroE</name>
        <name evidence="6" type="ordered locus">ANT_01900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558622.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01900"/>
    <dbReference type="EnsemblBacteria" id="BAJ62224">
        <property type="protein sequence ID" value="BAJ62224"/>
        <property type="gene ID" value="ANT_01900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01900"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_2_0_0"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="5">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="292" mass="31453" checksum="B2CAD9B41BFBC54F" modified="2011-04-05" version="1">MSALCLGLLGFPLGHSLSPRLHTAALSAMGLEGEYRLYPVPPLPEGETAWRALFERLRAGDLHGLNVTIPHKQTVMKELDFCEDEARIIGAVNTLGVDDSGRVWGANTDSPGFLRDLYAQLGDVLPLQGGRALVLGAGGAARAVVYALIRAEWEVWVSARRGEQAQTLAESLRTFLPYAPLTALEGVPPREALPPRLNLLVNATPLGMSPHPDTLPWNEALPIPEGTAVYDLVYNPRETRLLAFARACGAPAAGGLGMLVEQAALALERWSGQMVPRSVMWQVVAEDSNPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ94</accession>
    <name>E8MZ94_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558635.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02030"/>
    <dbReference type="EnsemblBacteria" id="BAJ62237">
        <property type="protein sequence ID" value="BAJ62237"/>
        <property type="gene ID" value="ANT_02030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02030"/>
    <dbReference type="HOGENOM" id="CLU_2646593_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="76" mass="8339" checksum="FCB308266AECECE5" modified="2011-04-05" version="1">MRKPLGSFFFSVGLVLLVLFVFSDIAEQPQFGLFAGGAVCLILGTALWLTSPRPASGEPPARFRTVKKLMQRKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP3</accession>
    <name>E8MZP3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560946.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64591">
        <property type="protein sequence ID" value="BAJ64591"/>
        <property type="gene ID" value="ANT_25650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25650"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_0"/>
    <dbReference type="OMA" id="TQTAKVH"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="227" mass="25493" checksum="94146DB9CB5B7955" modified="2011-04-05" version="1">MNWKAFIFDMDGTLLDNMAFHIEIWREFLHSLGVKLDEKEFLQRAVGRTNADILRDFVNPDLSDEEIRALGKQKEALYRSRFRPLMREVPGLTRLLARAKQKGIRIALATSAGVENARFVLEGLDIESYFDVLVTGDQVTQGKPHPEIFLKAAERLSIHPSEGLVFEDSPLGLEAAHRAGMASIALSTTYPPEHLMTLPGVLAVVPDYDTLFLRDGHLGEFFHSFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT7</accession>
    <name>E8MZT7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="8">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">folD</name>
        <name evidence="12" type="ordered locus">ANT_02380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02380"/>
    <dbReference type="EnsemblBacteria" id="BAJ62272">
        <property type="protein sequence ID" value="BAJ62272"/>
        <property type="gene ID" value="ANT_02380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02380"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_0"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="1 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="10">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="11">
        <location>
            <begin position="146"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="33524" checksum="7D3E0BCC8D91B03C" modified="2011-04-05" version="1">MNRRNGSIMTSNTLSAKKEEHNMPAQILDGAAMAEKIRQQIAQEVAQRLAEGKPAPGLATVLVGDNPASQVYVKSKHKACQQVGIRSMGYELPATASQQEVMDLVKRLNDDPAVNGILVQLPLPSGLDEEKVLGAISIEKDVDGFHPINIGRLAQKGREPLFVPCTPAGCMVLIESVLPDLNGANAVVLGRSNIVGMPVALLLVRANATVTICHSRTRNLKEVCRSADVLVAAVGRAEMVRVDWVKPGAVVIDVGINRVEDATQPRGYRLVGDVAFDEVKDVAGWLTPVPGGVGPMTIAMLLQNTLRAARLSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N021</accession>
    <name>E8N021_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03220"/>
    <dbReference type="EnsemblBacteria" id="BAJ62356">
        <property type="protein sequence ID" value="BAJ62356"/>
        <property type="gene ID" value="ANT_03220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03220"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1871099_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="15893" checksum="85A5654B4806F2AB" modified="2011-04-05" version="1">MKIYLDVCAIQRPLDTFDQIRIVLEAEAVLGILSLFERGILELFSSDALVFETEQNPFPLRREHARAVLSKAREHLSLSPEAIQRAKQLTIWVSNLWMHCTWHWRKQEKPIISAPAMTGYCENQNKLSYRSKAFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8N023</accession>
    <name>E8N023_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62358">
        <property type="protein sequence ID" value="BAJ62358"/>
        <property type="gene ID" value="ANT_03240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03240"/>
    <dbReference type="HOGENOM" id="CLU_3211696_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="44" mass="5029" checksum="F3C8DCFB24D25731" modified="2011-04-05" version="1">MKVKKMFSSFSLFILFLIAVLVIILENPLPVWAVRMSAGMNEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0C3</accession>
    <name>E8N0C3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64672">
        <property type="protein sequence ID" value="BAJ64672"/>
        <property type="gene ID" value="ANT_26460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26460"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_0"/>
    <dbReference type="OMA" id="FLAEGPQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="28938" checksum="0845704DB1338451" modified="2011-04-05" version="1">MPVEKITSLHNPRIQSIRALIQRREERRERGWFVAEGVRLVEEGVQAGWQAVMALYSADLSARGQALLPALHAQGAEVFEVPASLLKQISDTETPQGILTVFARRVYSLPEPLDFVVIADNLRDPGNLGTLLRSAAAAGAQTVWLTPGTVDAFSPKVLRAGMGAHFRLPVQEVSLEWMRDFRHQHPGMHLYLAEAENGTPCWDTDLTQPLALVIGGEAEGASLEMRALVDGNITIPMPGKSESLNAAVAAGILLFEVVRQRRQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0D9</accession>
    <name>E8N0D9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561040.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64688">
        <property type="protein sequence ID" value="BAJ64688"/>
        <property type="gene ID" value="ANT_26620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26620"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_8_0_0"/>
    <dbReference type="OMA" id="HHVPKRT"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023312">
        <property type="entry name" value="Put_nitroreductase_C_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="192" mass="21550" checksum="ACAD0D3454EF487F" modified="2011-04-05" version="1">MSTISELICKNRSYRRFYQQEAVSMETLRDLVDLARLSPSAANRQPLRYYLSCDSETNAKIFPTLAWAGYLRDWQGPEEGERPSAYIIILLDTEISKNAGCDHGIAAQSILLGATERGLGGCIIASIQRDALRTALDIDPRYEILLVLALGKPKETVVIEPLPPDGDIRYWRTPDGVHHVPKRSLDDLILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E8</accession>
    <name>E8N0E8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <shortName evidence="15">FBP A/P</shortName>
            <shortName evidence="15">FBP aldolase/phosphatase</shortName>
            <ecNumber evidence="6 15">3.1.3.11</ecNumber>
            <ecNumber evidence="15">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fbp</name>
        <name evidence="16" type="ordered locus">ANT_26710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6 15"/>
    <dbReference type="EC" id="4.1.2.13" evidence="15"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561049.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64697">
        <property type="protein sequence ID" value="BAJ64697"/>
        <property type="gene ID" value="ANT_26710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26710"/>
    <dbReference type="eggNOG" id="COG1980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041630_0_0_0"/>
    <dbReference type="OMA" id="YMRRHGP"/>
    <dbReference type="OrthoDB" id="736548at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02067">
        <property type="entry name" value="FBP_aldolase_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="FBP binding" evidence="15">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for FBP phosphatase activity" evidence="15">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor; for FBP aldolase activity" evidence="15">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DHAP; for FBP aldolase activity" evidence="15">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAJ64697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="372" mass="41359" checksum="6AA11BD5305F0881" modified="2011-04-05" version="1">MSEKLTLSVIKADVGGFVGHSAIHPDLIDTARMALEEARQKGWLIDFHVTACGDDLQLIMTHSRGVDDVEIHHLAWQVFERCTAIARKLKLYGAGQDLLTDAFSGNVRGMGPGVAEMELHERESEPVIIFMADKTSAGAWNLPLFRMFADPFNTAGLVISPSMHEGFRFEVHDVKQHKRIFFDTPAEMYDLLVFIGASGRYVIKAVYTRDGEIGAVSSTQRLALIAGKYVGKDDPVCIVRSQGKFPAVGEVLEPFTMPHIVEGWMRGSHYGPLMPVPVRQATPSRFDGPPRVAALGFQLANGGLIGPRDLFDDPGFDEVRRQVNVLADQLRRHGAFEPHRLPMDEMEYTTLPQVMEKLAERWEALPDEPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E9</accession>
    <name>E8N0E9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561050.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26720"/>
    <dbReference type="EnsemblBacteria" id="BAJ64698">
        <property type="protein sequence ID" value="BAJ64698"/>
        <property type="gene ID" value="ANT_26720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26720"/>
    <dbReference type="eggNOG" id="COG5637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136031_0_0_0"/>
    <dbReference type="OMA" id="HVRIDYT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="16590" checksum="14C628558E29ED0B" modified="2011-04-05" version="1">MAHVKKSIYIHAPVEKVYALARDPNRWATFYVGLSEAEEITGHGEVGTVVKHHYLMAGMRFPVTSRVLVDSIGPTGAQWKGKIEGPLDGEQTWDYIPKNGGTEVTVSIDYTLPGAVLGRIANRLLVERIQERAMEQTLENLKILCEEGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G9</accession>
    <name>E8N0G9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561070.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26920"/>
    <dbReference type="EnsemblBacteria" id="BAJ64718">
        <property type="protein sequence ID" value="BAJ64718"/>
        <property type="gene ID" value="ANT_26920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26920"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_3_1_0"/>
    <dbReference type="OMA" id="PHYHIIN"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="166" mass="19511" checksum="B2663A1D5C07C3B6" modified="2011-04-05" version="1">MESLYQQVTLRLRDEGGRMTSQRRLILQALEELGGHPTAEEIYRHVSRQSPGINLSTVYRTLNWLEENGFIAPRWFEEERRRERFEPAVLTAPSRHPTPFHFRCRSCNRILEFADPRMEEIVKQFERHTGAQVKDVELTFYGLCQACARMEAHLVTADQQPKAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H6</accession>
    <name>E8N0H6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561077.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26990"/>
    <dbReference type="EnsemblBacteria" id="BAJ64725">
        <property type="protein sequence ID" value="BAJ64725"/>
        <property type="gene ID" value="ANT_26990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26990"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_0_0"/>
    <dbReference type="OMA" id="DESAQWL"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="54"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="168" mass="19926" checksum="03636A561F378B2E" modified="2011-04-05" version="1">MAITDLLPWKREERALAPRRREEDLFLTLRDEMDRMMEEFFNEPLFSLRPRMLERFGSFFPRVDVSENDKEIVVTAEVPGMDENDVEVSFKNGILTIKGEKRAEKEEKDRRYHRIERTYGSFRREIEMPCEVEEDKITATYKKGELTVVLPKSTRPEVVGKRIPVQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I5</accession>
    <name>E8N0I5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoglycoside 6-adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561086.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27080"/>
    <dbReference type="EnsemblBacteria" id="BAJ64734">
        <property type="protein sequence ID" value="BAJ64734"/>
        <property type="gene ID" value="ANT_27080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27080"/>
    <dbReference type="eggNOG" id="ENOG5030JAE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076578_1_0_0"/>
    <dbReference type="OMA" id="FDDCCNE"/>
    <dbReference type="OrthoDB" id="1182556at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007530">
        <property type="entry name" value="Aminoglycoside_adenylylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04439">
        <property type="entry name" value="Adenyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000812">
        <property type="entry name" value="AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="33773" checksum="2B215BBF226B62F6" modified="2011-04-05" version="1">MRTEQEMMDLILTFARNDERVRAVILNGSRANPNAPRDFFQDFDIVFVVTDDAPFKQDRSWMRCFGDLMIVQVPEEMGYPVEESSTDIYVYLMQFTDGNRIDLTIHPLQRLSELGRDSLSVLLLDKDGIIEPFPPPHEGDYLPKPPTPRQFADCCNEFWWVSTYVAKGLWREEITYAKAMMEVCRAQLFAILRWYIGMRTDFQVNPGKEGKYYRKYLEPERWARLLATYADADPRRTWNALFAMADLFRDTAQVVAQRFGLTYPQEEDSKVSAFLLQVRALPRTATSLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L2</accession>
    <name>E8N0L2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">mgsA</name>
        <name evidence="4" type="ordered locus">ANT_04860</name>
        <name evidence="5" type="ordered locus">ANT_27350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="5">UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558916.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04860"/>
    <dbReference type="EnsemblBacteria" id="BAJ62520">
        <property type="protein sequence ID" value="BAJ62520"/>
        <property type="gene ID" value="ANT_04860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64761">
        <property type="protein sequence ID" value="BAJ64761"/>
        <property type="gene ID" value="ANT_27350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04860"/>
    <dbReference type="KEGG" id="atm:ANT_27350"/>
    <dbReference type="eggNOG" id="COG1803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120420_0_1_0"/>
    <dbReference type="OMA" id="RACDVHN"/>
    <dbReference type="OrthoDB" id="1726279at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1 2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="151" mass="16799" checksum="A902C0BBE9E942AB" modified="2011-04-05" version="1">MHERKLVSQAKKHIALIAHDGMKQELLEWVDFNKGTLARHFLYATASTGKLIMENTGLPVSVLASGPLGGDLQIGSGIVEGKIDFLIFFWDPLEPQPHDPDVKALLRVAVLYNIPTASNRATADYLISSPLMESPYTRILPDFSHKIHREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N3</accession>
    <name>E8N0N3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="3">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_03940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558824.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03940"/>
    <dbReference type="EnsemblBacteria" id="BAJ62428">
        <property type="protein sequence ID" value="BAJ62428"/>
        <property type="gene ID" value="ANT_03940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03940"/>
    <dbReference type="eggNOG" id="COG0538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_7_1_0"/>
    <dbReference type="OMA" id="CVRPCRY"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004439">
        <property type="entry name" value="Isocitrate_DH_NADP_dimer_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43504">
        <property type="entry name" value="PTHR43504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00183">
        <property type="entry name" value="prok_nadp_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="426" mass="47609" checksum="9DCBADA75A0A7398" modified="2011-04-05" version="1">MSESGERITMQNGRLHVPSHPIIPFIIGDGTGPDIWRAAVRVFDAAVEKAYRGERRIIWKEVLAGEKAFNTLGTWLPEETLQAFREYLVGIKGPLTTPIGGGIRSLNVALRKELDLYVCLRPVRYFPGVPSPVRHPELVDMVIFRENTEDIYTGIEYEYGTEENARFKQLLKEHFPKDYAKIRFPETAGIGIKPVSKEGTARLVRAAIRYALENKRRNVTLVHKGNIMKYTEGAFRNWGYEVAETEFGEQTYTWAQWERTKAEKGEDSANAEQEAALKSGKLLVKDVIADIVFQQTLLRPREFDVLATMNLNGDYLSDALAAQVGGIGIAPGGNINYTTGHAVFEATHGTAPKYADKDMVNPGSVILSGEMMLRYMGWTEAADLIIRGMEGAIAAKTVTYDFHRLMEGATLLKCSEFGDAVIRHMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R5</accession>
    <name>E8N0R5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peroxiredoxin</fullName>
            <ecNumber evidence="5">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bcp</name>
        <name evidence="5" type="ordered locus">ANT_04260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558856.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62460">
        <property type="protein sequence ID" value="BAJ62460"/>
        <property type="gene ID" value="ANT_04260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04260"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_0"/>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="159" mass="17916" checksum="57E78BCCEDA3C2F3" modified="2011-04-05" version="1">MVLSANQPAPDFTLADETGAMRSLSEFRGKPVVLYFYPKDDTPGCTTEACNFRDDYHVYAENGVVILGVSPDSPKSHAKFKAKYNLPFTLLADEEHRVCEMYGVWGRKKFMGREYDGVFRTTFLIDPQGMIVKVWEGVKPEGHSQEVLEALRDWQGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R6</accession>
    <name>E8N0R6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Rrf2 family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04270"/>
    <dbReference type="EnsemblBacteria" id="BAJ62461">
        <property type="protein sequence ID" value="BAJ62461"/>
        <property type="gene ID" value="ANT_04270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04270"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_2_0"/>
    <dbReference type="OMA" id="YGLSAMY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="146" mass="16075" checksum="D8FC79EC20075378" modified="2011-04-05" version="1">MFRVSRRIDYGVQLMIALAQTEAERPVPTAVLAEKLHIPLPFLHQIGRSLIQSGYIRATPGPRGGLRLKQSPENISLLQIIEALEGPMRIVPESNGNGMMTREVWAELQEKVVAALASIRLSELAKKAPQGALLSVESINMAERNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T4</accession>
    <name>E8N0T4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558875.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62479">
        <property type="protein sequence ID" value="BAJ62479"/>
        <property type="gene ID" value="ANT_04450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04450"/>
    <dbReference type="eggNOG" id="COG2078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095686_0_0_0"/>
    <dbReference type="OMA" id="RGCIGFP"/>
    <dbReference type="OrthoDB" id="1812209at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="191" mass="22046" checksum="A4835FB60CE390A6" modified="2011-04-05" version="1">MSREPLSEEERRLLLQLARRSIEAAVNGKPLPEIRAEDYPARLFEPGVCFVTLTDARGELRGCVGALEAYQPLVEDVREHAVAAALEDYRFPPVRPHEVDHLKIEISRLTPPRPLPYENPEDLPRLLRPHVDGVILRDGIRRATFLPQVWEKIPNPEEFLSHLCQKMGAPASLWRKKKLDVYTYEVEEFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V4</accession>
    <name>E8N0V4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_04650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558895.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04650"/>
    <dbReference type="EnsemblBacteria" id="BAJ62499">
        <property type="protein sequence ID" value="BAJ62499"/>
        <property type="gene ID" value="ANT_04650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04650"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592863_0_0_0"/>
    <dbReference type="OMA" id="TWVEQQG"/>
    <dbReference type="OrthoDB" id="345245at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="104"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="488" mass="54787" checksum="C2C45275D22EB8BA" modified="2011-04-05" version="1">MATIDLTVHPDRLERAVQRARERGIIIPTFAQMKDPTRIPEKIREQLKQTGLWDVTPVNLFRITWKNEPKPFGGLFGGVNYIEFPSSLTGVPARIIALVGKWFPTGAHKVGAAFGCLVPRLVTGQFDPTSQKAVWPSTGNYCRGGAYDSALLGCQSIAILPEGMSRERFEWLSRIAGEVIATPGSESNVKEIFDKCWELRRSGEDLMIFNQFEEFGNYLWHYEVTGHAMEEVLRSALGSNDAYRGVALTTGSAGTIASGDYLKQVYPTSKIIASEALQCPTLLQNGFGAHRIEGIGDKHVPWIHNIKNTDIVVAIDDNDVVKIMRLFNEPVGQEYLQRKGVPVETIEKLNLLGFSGIANVLSAIKFAKYYELTGNDVVLTVLTDSMELYGTRIEEYREQFGEFTPSDAAEAFAGALHGVRTDALIELSYAERKRIHNLKYYTWVEQQGKTYEEIQAQWYDPNYWTDIQRQVGEIDAKIEAFNRMVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V9</accession>
    <name>E8N0V9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_04700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558900.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04700"/>
    <dbReference type="EnsemblBacteria" id="BAJ62504">
        <property type="protein sequence ID" value="BAJ62504"/>
        <property type="gene ID" value="ANT_04700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04700"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_0_0"/>
    <dbReference type="OMA" id="PLKDPMG"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="376" mass="40986" checksum="AFE288B394DFCC72" modified="2011-04-05" version="1">MNKSALTRSKANWLPFTVELEPRLTPPPGWFSWVLTIGMVIFALLIGALVIAFAGGNPWAAYSHIARSSFGSIGVLSDTLVKAIPLMIVGLACTIAFRMRIWNIGAEGQFFLGAFGASAVVLTPILPADSPQWLFILTMLIFGMAAGAIWGFIPGYLKAKFKVNEVISTLMLNYIAVSWNNYWIYAVWTEGGFQMSKMFPRNAWLPRLTDFADRVPAFGGLTVHFGLILALIAAVVVWLILYRSQWGYEIRVVGDNPPTANYAGIPIARNTVLVMMLSGALAGLAGMSEISGVVHRLQGAISPGYGYTGIIVAWLAKLNPFAVIPVAIFFGALILAGREIQPSGIPKMIQGIILVCLIASDFLMRYEIRIRRKGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z9</accession>
    <name>E8N0Z9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative polyphosphate kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_05100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62544">
        <property type="protein sequence ID" value="BAJ62544"/>
        <property type="gene ID" value="ANT_05100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05100"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048699_1_0_0"/>
    <dbReference type="OMA" id="NPRICRV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="4">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="33105" checksum="B7B22C52525BDE04" modified="2011-04-05" version="1">MGEAMERYFIKPGEKVRLKDWSPDPPKDFEGDKESTRAAVAELNRKLEVLQERLYAERKHKVLVILQGMDTSGKDGVIRSVFEGVNPQGVKVANFKVPTQEELDHDYLWRVHKVVPGKGEIVIFNRSHYEDVLVVRVHNLVPPEVWKKRYEQINQFERLLHETGTTILKFFLFISREEQKQRLLERLADPAKHWKFNPGDLKERALWEEYEKAYEDVLSRTSTEYAPWILVPADKKWYRDWVISRVLVETLEGLEIQLPPPLADAETYRRQLLEEDAPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N113</accession>
    <name>E8N113_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ctaB</name>
        <name evidence="8" type="ordered locus">ANT_05240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62558">
        <property type="protein sequence ID" value="BAJ62558"/>
        <property type="gene ID" value="ANT_05240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05240"/>
    <dbReference type="eggNOG" id="COG0109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030009_1_1_0"/>
    <dbReference type="OMA" id="WIAMSHR"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="598" mass="64102" checksum="365B8FF9A2C8BAF6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N128</accession>
    <name>E8N128_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561119.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27450"/>
    <dbReference type="EnsemblBacteria" id="BAJ64771">
        <property type="protein sequence ID" value="BAJ64771"/>
        <property type="gene ID" value="ANT_27450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27450"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262881_0_0_0"/>
    <dbReference type="OMA" id="NRETFRA"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142363" checksum="0A90BAE3F3EF4ED6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N146</accession>
    <name>E8N146_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfite reductase, dissimilatory-type subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dsrC</name>
        <name evidence="5" type="ordered locus">ANT_27630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DsrC/TusE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561137.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64789">
        <property type="protein sequence ID" value="BAJ64789"/>
        <property type="gene ID" value="ANT_27630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27630"/>
    <dbReference type="eggNOG" id="COG2920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153199_0_1_0"/>
    <dbReference type="OMA" id="EYNTSPA"/>
    <dbReference type="OrthoDB" id="1840461at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042072">
        <property type="entry name" value="DsrC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025526">
        <property type="entry name" value="DsrC-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043163">
        <property type="entry name" value="DsrC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007453">
        <property type="entry name" value="DsrC/TusE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37010">
        <property type="entry name" value="PTHR37010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04358">
        <property type="entry name" value="DsrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006223">
        <property type="entry name" value="DsrC_TusE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69721">
        <property type="entry name" value="SSF69721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03342">
        <property type="entry name" value="dsrC_tusE_dsvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006223-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="105" mass="11304" checksum="E6398E0E0629A8E2" modified="2011-04-05" version="1">MATRTIAGKTVQVNDEGFMTNPAEWTKEIAVELAKEEGIAELTEQHWKVIDFCRQTGLSSGKAPTLRQITTGTGLSTKDLFALFPKGPAKKVARISGLGKPEGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N154</accession>
    <name>E8N154_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrite reductase</fullName>
            <ecNumber evidence="8">1.7.2.1</ecNumber>
            <ecNumber evidence="8">1.7.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nirS</name>
        <name evidence="8" type="ordered locus">ANT_27710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.7.2.1" evidence="8"/>
    <dbReference type="EC" id="1.7.99.1" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561145.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64797">
        <property type="protein sequence ID" value="BAJ64797"/>
        <property type="gene ID" value="ANT_27710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27710"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025262_0_0_0"/>
    <dbReference type="OMA" id="MPNWGTS"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003143">
        <property type="entry name" value="Cyt_cd1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228548" evidence="6">
        <location>
            <begin position="19"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="43"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="182"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="689" mass="75104" checksum="8C10CA9FD8F2012C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E9</accession>
    <name>E8N1E9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64892">
        <property type="protein sequence ID" value="BAJ64892"/>
        <property type="gene ID" value="ANT_28660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28660"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308743_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="2">
        <location>
            <begin position="34"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="437"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="963" mass="108652" checksum="7E1CD96D4CA4AE4A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G8</accession>
    <name>E8N1G8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative magnesium-chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62573">
        <property type="protein sequence ID" value="BAJ62573"/>
        <property type="gene ID" value="ANT_05390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05390"/>
    <dbReference type="eggNOG" id="COG1240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_2_0_0"/>
    <dbReference type="OMA" id="INMEHAA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="98"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="291" mass="33096" checksum="5624E7FC2473E4B1" modified="2011-04-05" version="1">MNTGETFEARRLDTPLDKMMRRHAGRRSRTYTDRKRGRYILARPAGRRRDDLAFDATLRTAAPFQRQREELKKRNRVAFAVRPSDYMRKVRVRRAANLVLFLVDASWSMAVAERMQATKGAILSLLNDAYQRRDRVGLITFQRDRATLILPPTNSVQLAEQALRDIPVGGKTPLSAGLDMAYGILKREKMLHPDVLPLLIVLTDGAGNVSMGHLPPLEEAHYLAERIAEEHIHAVVINMEHAAFDQGLAQELANHLKAPCYNLTDLRAESLYYTVRQEMQSTALKGLEDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1L4</accession>
    <name>E8N1L4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62619">
        <property type="protein sequence ID" value="BAJ62619"/>
        <property type="gene ID" value="ANT_05850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05850"/>
    <dbReference type="eggNOG" id="ENOG5031JA4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1912691_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="132" mass="15893" checksum="624E806C0F80D607" modified="2011-04-05" version="1">MGWLRQWASDERGHQHQSAHHGAGSRWAHRRRHVLRHYYGFEILGNKEWWATYESYNGWMRWGLGMAQPSYPWPEYQHELGGARVYYITKKYWDQLVKDYIRQMVGADLDFNVPDEVRKANEVMRVPDDILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P0</accession>
    <name>E8N1P0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559040.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62645">
        <property type="protein sequence ID" value="BAJ62645"/>
        <property type="gene ID" value="ANT_06110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06110"/>
    <dbReference type="eggNOG" id="COG2250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_2_1_0"/>
    <dbReference type="OMA" id="GRHEWAC"/>
    <dbReference type="OrthoDB" id="2025059at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="9"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="129" mass="14593" checksum="323E9CD87C17CCCF" modified="2011-04-05" version="1">MANRAGDWLRQAERDLEQARDSQRAGRHEWACFAAHQAAEKALKSLHLHFGQEAWGHVVARLFSDLPAQVQIPENLVEKGRVLDNFYVPTRYPNGHPEGAPFEHYGILQSEQAITYAGEILAFVRSQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q2</accession>
    <name>E8N1Q2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559052.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62657">
        <property type="protein sequence ID" value="BAJ62657"/>
        <property type="gene ID" value="ANT_06230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06230"/>
    <dbReference type="eggNOG" id="COG2178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099315_0_0_0"/>
    <dbReference type="OMA" id="EKTHGDI"/>
    <dbReference type="OrthoDB" id="1089815at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="PTHR10741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741:SF2">
        <property type="entry name" value="PTHR10741:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="221" mass="25171" checksum="13ED22359679D0B9" modified="2011-04-05" version="1">MKTLPEIAERIHQALEARTRARDQVLTQARVLTRHAAHAIRAAHREEWSIAAEQLEQARLLVRQLQQDLAPYPELYFAGYTQDAIKEFAEASIACALIQNLSLPTPEELGVEDVTYLNGLAEAAGELRRRCLDILRQGYSQEAERLLSCMDDIYDVLVTMDYPDAVTNGLRRQTDVARSLLERTRGDITLSQREQHLEQVIRDAVKRLESPSHDSPDNPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R8</accession>
    <name>E8N1R8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559068.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62673">
        <property type="protein sequence ID" value="BAJ62673"/>
        <property type="gene ID" value="ANT_06390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06390"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920236_0_0_0"/>
    <dbReference type="OrthoDB" id="1401502at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="302" mass="34375" checksum="ED3A0D04ED6D5C0F" modified="2011-04-05" version="1">MSLITLFTAPKPFTDPHIALIQHNAIRSWLALGDEVEVILLGEEEGLAEAAALYGVKHLPQVARTASGTPLVSSMFALAREHSTSPLLCCVNADILLTPDLLTVGRAMLEKHSRFLVVGQRWDLDVHEPLEFTAGWAGRLRRRAQQEGKLHKATGSDYFLFPRGCFSDMPAFAIGRAGWDNWMIYSGRAQHFPVVDATHDLFIVHQNHDYRHLPGGQPHYKHPETLENIRLAGGRRAIFELPDVSHRLVKGKLVRPPLTWQRFWREVEIFPLVTLHSYPLALAMYFLLHPRKAYREYREGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1U2</accession>
    <name>E8N1U2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559092.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06630"/>
    <dbReference type="EnsemblBacteria" id="BAJ62697">
        <property type="protein sequence ID" value="BAJ62697"/>
        <property type="gene ID" value="ANT_06630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06630"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="PEIDRKW"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="273" mass="31102" checksum="4B6624AC959ABAF9" modified="2011-04-05" version="1">MKGEVVLQGVNLTKVFGWGKTKTVAVDHVNFEIREGEVCSIVGESGSGKTTLAKMLLGLLNPTEGEIYFQGKKRDISTQRKKREYWKSIQAIFQDPYSAYNIFNKIDTLLLDCIRMRGDFWLPREKKIELMSEACSFVNLEYKELTNKYPFELSGGQMQRLMIARIFLLKPKILIADEPTSMIDACSRATILDMLMKLRDEVGMTIVFITHDIGLAYYVSDNVFIMERGKIVESGSAEQVILTPHHPYTKRLISDVPKIHEAWDLSTVTYSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N205</accession>
    <name>E8N205_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561296.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64952">
        <property type="protein sequence ID" value="BAJ64952"/>
        <property type="gene ID" value="ANT_29260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29260"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041132_3_1_0"/>
    <dbReference type="OMA" id="YYCGDDF"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="397" mass="45186" checksum="12B49B503C3C61B9" modified="2011-04-05" version="1">MSRPPVSTGESLVCPPLVLVKTLWWHAKQTLRALRSPRQVQHIQHSLTEWADGKRVWVFAPGLSWQKQLFQRPQQLAKALADLGERVIYLEPEWAWQGKPLVIPLGESLLLCCAPPQALSGLERPWLYLLPWSYSPAFALRGSRLIYDIVDDFSTFKQVHPCLLAHQHRQRMARAEVVLVTARRLRDTFQAERDDLILCPNGVDVNFFACKPERLAPEIEELRKEGKPIIGYIGALAEWFDDNLLESVARLRADLSFVLIGPQLHGGQEKRPWQKLANVHWLGVRPYESLPAYLYGFHAVMIPFRLNPITHATSPLKLFEALAAGKPVVMTPMQESLSVPLVFPASTPQEWSDQLDRALAQGAQEAFQNALRQEAARHTWHSRARQILEAVERISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N224</accession>
    <name>E8N224_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561315.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29450"/>
    <dbReference type="EnsemblBacteria" id="BAJ64971">
        <property type="protein sequence ID" value="BAJ64971"/>
        <property type="gene ID" value="ANT_29450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29450"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_0"/>
    <dbReference type="OMA" id="IEGPCHH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="312" mass="34651" checksum="24E5399CFE57DBFD" modified="2011-04-05" version="1">MFDPHQLRVFIVAAETLNFSQAAKKLNLSQPAVTQTIQSLEAQLGKALFHRQQRKLALTEEGQAFLPVAHQLVALNIRARDLVETSRDQVTGQLSIACSTTPGKYILPVVLSHFISRYPRVSAQCLVTSRADALSALEQGNAQFAFSSSIEEFDHHYEFFPFIVDPVLLIVPADHPWAGKGEIDLEELPRERFILREETAGTYRVVKTELARHGFNIHDLPVTLRLGNSEAIAIAVSEGTGVGFVSGILLRHLRLPNVAVVRVHGMTFEQTIYMCRHRLNPTGNAGAAFWQFIHTERGSIQRQLLGESAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N226</accession>
    <name>E8N226_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29470"/>
    <dbReference type="EnsemblBacteria" id="BAJ64973">
        <property type="protein sequence ID" value="BAJ64973"/>
        <property type="gene ID" value="ANT_29470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29470"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420264_0_0_0"/>
    <dbReference type="OMA" id="WNLRFVR"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="793" mass="84451" checksum="F5BCA07056AFC460" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N280</accession>
    <name>E8N280_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5655 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30010"/>
    <dbReference type="EnsemblBacteria" id="BAJ65027">
        <property type="protein sequence ID" value="BAJ65027"/>
        <property type="gene ID" value="ANT_30010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30010"/>
    <dbReference type="eggNOG" id="COG3586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1902317_0_0_0"/>
    <dbReference type="OrthoDB" id="813740at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043714">
        <property type="entry name" value="DUF5655"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18899">
        <property type="entry name" value="DUF5655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5655" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="133" mass="14854" checksum="D05F7A8E0F382667" modified="2011-04-05" version="1">MVAAGKKAALTRATAVYTFEEHLEGKSDGIKELAFAIQEFITGLDSTIQEVPKKNYIAYKTSQNIVCMELQNQRILLYLKLNPKEISNPPKISRDMTGKGHYGSGDFEISVKSMEDFEVAKPYILMAYQKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N293</accession>
    <name>E8N293_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alpha-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_30140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561381.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30140"/>
    <dbReference type="EnsemblBacteria" id="BAJ65040">
        <property type="protein sequence ID" value="BAJ65040"/>
        <property type="gene ID" value="ANT_30140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30140"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="OMA" id="IDMLCDG"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="198"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ65040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="448" mass="50245" checksum="0380360568AFC9DC" modified="2011-04-05" version="1">MKKTIVLIGAGSAQFGYGTIGDILQSKVLEGSHIVLHDINPTTMGVVERTARQFIEEHGLPFTISATTNRAEALQGADFVISSIEVGDRFELWEQDWRIPQQYGIRQVYGENGGPGGLFHSLRIIPPILDIVADVMRICPDAYVFNFSNPMSRICTTVHRAFPDAKFIGLCHEIGSLRRFLPEILGVPYEALEVRAGGLNHFSVVLSAKYKDTGKDAYPDIRAKAPAFFANMPSLSAEHKYFKETGKWPETKEDFAHVETEAWPERRVFQVILEKFGLMPITSDSHFGEYIQWAYDVTDHRGILDFYRFYKQYLSTVQPKIELTLKERVVPIIEGILTDAGYVEEAVNIPNKGLIDDLPEWIAVEVPAIVDKNGVHGIPLGKLPAGFKGLLMNQVAVHDLTAEAVIHKSKALALQALMVDPVVDIYQGLEELLDTMIEYQEKWLGYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F7</accession>
    <name>E8N2F7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">parA</name>
        <name evidence="2" type="ordered locus">ANT_07290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559156.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07290"/>
    <dbReference type="EnsemblBacteria" id="BAJ62763">
        <property type="protein sequence ID" value="BAJ62763"/>
        <property type="gene ID" value="ANT_07290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07290"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003316_0_0_0"/>
    <dbReference type="OMA" id="CEFFALR"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="259" mass="27845" checksum="AC26D4687ADBA10B" modified="2011-04-05" version="1">MKTIAVCNQKGGVGKTTITLNLSAGLAMVGQKVLMIDLDPQASLTLSTIGESSGQCIAEVIGSSLPGKLSILEIIHPLQENFHLAPGGLSLSISEIGLVTRLGRENILKKVLSAIDHHYDVAIIDCGPSMGLLVENALNAANAVIIPTLPTPIDKKGVSILLESLQAVRNELNPDLEILGLVISQYDQRLKLHQQMLDEFRMMDLPLLAIIGRSVEVARTIGEGKPLTSGRLLPQMHELTSKVDFWIKHGKLPDSFLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J8</accession>
    <name>E8N2J8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07700"/>
    <dbReference type="EnsemblBacteria" id="BAJ62804">
        <property type="protein sequence ID" value="BAJ62804"/>
        <property type="gene ID" value="ANT_07700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07700"/>
    <dbReference type="HOGENOM" id="CLU_1544459_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="18775" checksum="FBBB103C95677C5A" modified="2011-04-05" version="1">MNKRIQVLVGIALMIAMVLAFFGFQTRGQAALGNVGFPIYCVKSNVSPGNVFNLTCYDDAAGTTFSDVPTGYYLLVTDAFITPSPTCGTDKGILHIDIFDSNVVGSTTYNEDGIELRELDRETFGFSFQSPGLIVQANHFLRAQANGGNVCNVDVRVYGWLVTNLSFLPVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N9</accession>
    <name>E8N2N9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_08110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559237.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62845">
        <property type="protein sequence ID" value="BAJ62845"/>
        <property type="gene ID" value="ANT_08110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08110"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594017_0_0_0"/>
    <dbReference type="OMA" id="EEVVWDP"/>
    <dbReference type="OrthoDB" id="534071at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="466" mass="51242" checksum="527792C21FF85BD8" modified="2011-04-05" version="1">MTTALSLPEPLIKPPLDPGFRPAVSATHAFHQKVSGEGVPLAMALEREDGQVSHFETSVFPEGHPLAGQNFPYVERLLKFLLWQRGAHTVYIGGNPRLAQQLANTYGTNGKRHFDAQFLGEKVYEQPFRVIACSLEEVPLDRETRKSLGRHLEGCRIGFDLGASDRKVSAVMNGVAVYSEEVIWEPRKHADPEYHYREILTALKTAASQMPRVDAIGGSAAGIYIHNRPRVASLFRSVPQERFGEIYTLFERLQKEMGVPLEVINDGDVTALAGSMSLGENAVLGIALGSSEAAGYVDAQGAITGWLNELAFAPIDYSPAAPYEEWSGDQGCGATYLSQQCVFRLAPQVGIDLPLNIPDAERLALAQKHLHEGHEGAVRIWQTMGVYLGYALAHYADFYEVKHVLILGRCTSGEGGNLLLEGVRTVWQAEFPHLLEQIQVHLPDEKIRRVGQSVAAASLPELMKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U7</accession>
    <name>E8N2U7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribonucleoside hydrolase</fullName>
            <ecNumber evidence="4">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561438.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30710"/>
    <dbReference type="EnsemblBacteria" id="BAJ65097">
        <property type="protein sequence ID" value="BAJ65097"/>
        <property type="gene ID" value="ANT_30710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30710"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036838_10_0_0"/>
    <dbReference type="OMA" id="DIDDTWA"/>
    <dbReference type="OrthoDB" id="1763387at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="304" mass="33508" checksum="5A5736A66F384571" modified="2011-04-05" version="1">MSHPIPLILDTDIGTDIDDTWALAVLLRSPEVDVRLALSATGDTAYRARLLAKFLQVSGRCDIPVGVGVYAEDESLPRRLQEAWVQGYALEDYPGRVHADGVAALIETILNAPEPVTLLAIGPLTNIAAALEREPSIARRTHFVGMHGSIYRGYGGAPEAHAEYNVKLDVPASRKVFSADWLSFTLTPLDTCGLVTLQGERYAAVRDSSHPITRALMENVRLWCAASPPWLKIPIDPERQSSTLFDVVAVYLAFADDLLEMRTLPLIVDEAGFTRVHPEGKAARCALAWKDLPAFEQWMVERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W3</accession>
    <name>E8N2W3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561454.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30870"/>
    <dbReference type="EnsemblBacteria" id="BAJ65113">
        <property type="protein sequence ID" value="BAJ65113"/>
        <property type="gene ID" value="ANT_30870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30870"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_6_1_0"/>
    <dbReference type="OMA" id="PWYGIGR"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="25255" checksum="612537FD04DB6FE5" modified="2011-04-05" version="1">MDFLLELFRWFVDFVLHMDRHLPQIVNDIGIWVYAVLFLVIFIETGLVVTPFLPGDSLLFAAGAVAATTSLHPLFLWVLLATAAVLGDTANYWIGHFVGPKVFTQESRWFKREYLERTHAFYEKHGGKTIFLARFIPIIRTFAPFVAGIGRMRYGYFISYNVIGGIVWTGLFIGAGYFFGNLPIVKENFSLVIIAIILISLIPAVVEYLKEKRRPHPAVVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z3</accession>
    <name>E8N2Z3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">cheB</name>
        <name evidence="8" type="ordered locus">ANT_31170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561484.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31170"/>
    <dbReference type="EnsemblBacteria" id="BAJ65143">
        <property type="protein sequence ID" value="BAJ65143"/>
        <property type="gene ID" value="ANT_31170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31170"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_0"/>
    <dbReference type="OMA" id="MLEMHRA"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="7">
        <location>
            <begin position="163"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3 5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ65143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="347" mass="36908" checksum="8C47D602059450C5" modified="2011-04-05" version="1">MNTRPIRVLVVDDSAYIRKVVSEMLSRDPLIQVVGTARNGRDALEKVQALQPDVVTLDLIMPELDGIGFLKEQMRRRVLPIIVVSIASENGELVVQAMENGAVDFVQKPTALASERVYEIQEDLIAKVKTAANIEPARISTSISIPAAPIAAPAERAGKVDAVVLGISTGGPQALAQLIPALPGDLPVPMAVVLHMPPGYTALFAARLNEISRLEVLEAAEGDEMRPGRVLLAPAGQHLTLRRTPESRVVAALSLRPLDTPHRPSVDVLFKSAAEVYGSRLLGIVMTGMGNDGTSGAAWIKSQGGTVIAEARESCVVYGMPRSVVEAGLADFSVPLQGMAEAILKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N316</accession>
    <name>E8N316_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561507.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31400"/>
    <dbReference type="EnsemblBacteria" id="BAJ65166">
        <property type="protein sequence ID" value="BAJ65166"/>
        <property type="gene ID" value="ANT_31400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31400"/>
    <dbReference type="eggNOG" id="ENOG502ZKWH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1802066_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="143" mass="16168" checksum="B903BA4F9BCA130D" modified="2011-04-05" version="1">MLKTQSLNLLKALTRVKLLWLPCLIPLPLLLIWQELFLRLEVCALLIPSTLFLHEWLHLLFIPNDARVEICVSWHSICLKMEGTRLYLQALLAALAPSLILSGVGLLVAQFDGLFALPFLMHAISFPIDLWGWYGGVVSHEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N320</accession>
    <name>E8N320_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gatB</name>
        <name evidence="12" type="ordered locus">ANT_31440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561511.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31440"/>
    <dbReference type="EnsemblBacteria" id="BAJ65170">
        <property type="protein sequence ID" value="BAJ65170"/>
        <property type="gene ID" value="ANT_31440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31440"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_0"/>
    <dbReference type="OMA" id="QIYAYEN"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="328"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ65170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="477" mass="53864" checksum="D0C187BC086BAD3C" modified="2011-04-05" version="1">MSEYEAVIGLETHIQLNTTTKIFCSCKADSWNEPPNTNICPVCTGLPGVLPVLNKAVVEKAVLLAHAMHAEIRPISYFDRKNYFYPDLPKGYQISQYDMALAHGGYFDLPMPQGYVRRVTIHKLHIEEDAGKTKNVNGQRYIDFNRCGVPLIEMVTGPDLRSADEAAQYLIRLRQLLRWLGISEADMEKAHLRCDANVSIRPKGATILNPKTEIKNVNSIDAVRNAIQNEIERQIREVEAGRRVEAWTLDWDDETQTLRKMRSKETEADYRYFREPDLLPVRLDDAWKASILANFPELPLARRARFVEQYGLPEYDAEILTAERSLSDYFENAVRAYGGDPKKISNWMMNDVLRLINERGLDPAAMRLSPAHLAEIQRLVDGGTINLTTAKALLVKVEESGNSPSAIVEAEGLAKVSDDSAIRAVAQEVLAENPKEVESYRKGKVTLIGWFVGQVMRKMRGKADPNVARQVLEDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B3</accession>
    <name>E8N3B3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytR family transcriptional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_08930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559319.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08930"/>
    <dbReference type="EnsemblBacteria" id="BAJ62927">
        <property type="protein sequence ID" value="BAJ62927"/>
        <property type="gene ID" value="ANT_08930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08930"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777655_0_0_0"/>
    <dbReference type="OMA" id="TGVRMDH"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225258" evidence="2">
        <location>
            <begin position="25"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="121"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="356" mass="38958" checksum="0663FAA38E2F3E32" modified="2011-04-05" version="1">MKKVLVFILTLIFITQACSLPMQAVEIASSTPIAPGKSYQFVTPALDATATPTPFQPLPITPTPIPTATPTPEPTPTLGIEAPDVQMPQSPFGIPAGGAVSGDVVNILILGSDARPGGGFRTDVIVLVSVHRNDNTIRMVSFPRDLYVDIPGWMTNRINTAFAAGGFNTLAYTFEYNFGVRPTYYVMTNMQAFVSIIDSMGGINVKVRKSLSDKCDLPWADGRGYCTIEAPATVPMDGKTALWYVRSRYSSSDFDRLRRAQEVLYGIFQKLMSLDGISRAPEIYAAYANSVETNLTLDTLITLAPVAQEVIQNPERIQRYALSPAEAAPYITPEGAWVLWPNLYAIRAIVYEAVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3D8</accession>
    <name>E8N3D8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_09180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559343.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62952">
        <property type="protein sequence ID" value="BAJ62952"/>
        <property type="gene ID" value="ANT_09180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09180"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673771_0_0_0"/>
    <dbReference type="OMA" id="WWIRASG"/>
    <dbReference type="OrthoDB" id="754057at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="408" mass="45186" checksum="55A18045B95A5C6B" modified="2011-04-05" version="1">MRVWFSLRRTWLSLELPILLAGAGLGLFSRNALILSVMLIPVFWLLHERKDRRTPLDVPVLIILLAFCISYWVSPLKDWTAEQIARALSGIGVCYALARQKEDLDLRLILYGIALLSVILAGVGLFTIQWVPNKIPMLNPLDWIGYLPQLGEKVHPNVFAGNLALLLPVSAAIFLWGKGRIHLLRAPVALLTGSLVLAVLALTLSRGALLAALTSLILLVILRWKLPALLGITVLGVIGWLIFPSMHSLIKPLYWFSSAEASLDLRQALWQRGLWLIEIFPLSGTGMGTYGLAVNHLFPMPSPLAPASHAHNLFIQIALDTGIPGLLAWLACLWQCTKWAWRAYRTPSTAPWWIRASGAAGLGAFWVLVFHGITDAVTWGTRPAVLLWAIWGWMILVEKVRASSLKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P7</accession>
    <name>E8N3P7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmJ</name>
        <name evidence="6" type="ordered locus">ANT_10270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10270"/>
    <dbReference type="EnsemblBacteria" id="BAJ63061">
        <property type="protein sequence ID" value="BAJ63061"/>
        <property type="gene ID" value="ANT_10270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10270"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="37" mass="4297" checksum="D315E3D089AA2D3B" modified="2011-04-05" version="1">MRVSPSIKKRCAKCKIVKRGGRLYVICENPKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Q0</accession>
    <name>E8N3Q0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsD</name>
        <name evidence="10" type="ordered locus">ANT_10300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559455.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10300"/>
    <dbReference type="EnsemblBacteria" id="BAJ63064">
        <property type="protein sequence ID" value="BAJ63064"/>
        <property type="gene ID" value="ANT_10300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10300"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_0"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="212" mass="24724" checksum="F54B335CC76907FD" modified="2011-04-05" version="1">MGKYLGPVCKLCRREGEKLFLKGERCYSPKCSFEKRGFAPGQHGRTQQGRSERESDYARQLRAKQKARRVYGIFERQFRRYFGLALRKKGLTGLNLLQTLEMRLDNVVFRMGFASSRAQARQLVNHGHIQVNNHRADIPSMLVKPGDIISVKESARSLTYWKDLLDVVDRRTCPMWIDRDTKNLSGRILRLPERSEIDGNLNEQLIVEYYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3R8</accession>
    <name>E8N3R8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ordered locus">ANT_10480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63082">
        <property type="protein sequence ID" value="BAJ63082"/>
        <property type="gene ID" value="ANT_10480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10480"/>
    <dbReference type="eggNOG" id="COG1007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_2_0"/>
    <dbReference type="OMA" id="FYIRVIV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="481" mass="50806" checksum="AAA3DBC27FF225B4" modified="2011-04-05" version="1">MTPAPFEPSMLLTILPEMLLVVLAALVLILNVGLRRQADGVLGWFTAIGLAVIAVLSAVFARPAETPQLIFGGMLRLDWVSFSFRLLFLLGAAITVLISIGHSRTLTGEYLALVLVATLGMSLMASSANLIMLYLAIETTSLPLYILAGFHIESQKSVESGIKYMLYGAVTSAVMLYGFSWLFGLSGTANLTMIPFRLTQSGVSSLLVGGALFLTLVGFGFKISVAPFHFWAPDVYEGAPTPIAGFLSTASKAAGFAVLVRVLLVVFPQMASFWTMVVAILAALSMIIGNLLALTQRNLKRLLAYSSIAQAGYILVGVAADSPLGVAGMVYYLASYLVTNLAAFAIVWLVAQQVGSEDLDAFAGLGKRNPAIALAMLISLLSLGGIPPLSGFIGKVLVFAAAIEAGQIALAILGVLTSVIGLYYYLTVMKTLYRPGADETPLKPSVSWKTAMLVCVVLMLALGVIVAPWYGQSLAAASALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S9</accession>
    <name>E8N3S9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NTP pyrophosphohydrolase</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mutX</name>
        <name evidence="3" type="ordered locus">ANT_10590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559483.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10590"/>
    <dbReference type="EnsemblBacteria" id="BAJ63093">
        <property type="protein sequence ID" value="BAJ63093"/>
        <property type="gene ID" value="ANT_10590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10590"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_27_0_0"/>
    <dbReference type="OMA" id="RWNGVGG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="159" mass="17885" checksum="902F7F004781C592" modified="2011-04-05" version="1">MLPKLQFTLCFLTRGDDVLMLHRNRPPNAGLWNGIGGHWEEDESALQGVLREIEEETGYHLEKAFFCGILTWEGFEIPAGGLVLFTAQAPEGEPQGCSEGKLAWKPKEWLFHSPEVVSNIHVFAPYILNGSNPLHFHFIYEAGKILAYKISPVPAELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V6</accession>
    <name>E8N3V6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpoC</name>
        <name evidence="11" type="ordered locus">ANT_10860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559510.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63120">
        <property type="protein sequence ID" value="BAJ63120"/>
        <property type="gene ID" value="ANT_10860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10860"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_0"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
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                <person name="Watanabe Y."/>
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                <person name="Fukui S."/>
                <person name="Takahashi M."/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
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    <dbReference type="HOGENOM" id="CLU_405805_0_0_0"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ63191.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
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        <name evidence="3" type="ordered locus">ANT_11840</name>
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        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559606.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63218">
        <property type="protein sequence ID" value="BAJ63218"/>
        <property type="gene ID" value="ANT_11840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11840"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_0"/>
    <dbReference type="OMA" id="IQLPYED"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="132" mass="15024" checksum="A3B4A9A81396DADD" modified="2011-04-05" version="1">MTDKTVLVVEDNVSNFVLIARMLGFLGIHCEWKTSGYEVVEYADTLPKLDLILMDIRLPYEDGYGALKKIRQSERLKNIPVIAVTAEASLEQMEKARKAGFDGFLGKPLDPDKFPDQIQRILNGESVWEMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N495</accession>
    <name>E8N495_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559647.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63259">
        <property type="protein sequence ID" value="BAJ63259"/>
        <property type="gene ID" value="ANT_12250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12250"/>
    <dbReference type="eggNOG" id="COG3649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071770_2_0_0"/>
    <dbReference type="OMA" id="YDFVLLF"/>
    <dbReference type="OrthoDB" id="598606at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013418">
        <property type="entry name" value="CRISPR-assoc_prot_Csd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02589">
        <property type="entry name" value="cas_Csd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01595">
        <property type="entry name" value="cas_CT1132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="288" mass="32434" checksum="54DB0BAC945D949B" modified="2011-04-05" version="1">MTTLSNRYEFVLLYDVENGNPNGDPDAGNMPRIDPETGYGIVTDVCLKRKIRNYVEMVKGDAPGYRIYIKEGIPLNANHKEAYLAVGLQPGQKATVEGVNRARAWMCQNFYDIRAFGAVLSVGDNCGQVRGPVQLNFSRSIDPIVQQEVTITRLTVTREEEAEKERTIGRKHIIPYALYRVEGYISAKLANDPTKGTGFSEEDLALFWEALINMFEHDRSAARGKMATRKLFVFKHESDLGNAPAHKLFDLVRVSKKAGINPPRSFMDYEVFVNRENVPQGVTLIEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4M5</accession>
    <name>E8N4M5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559775.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13590"/>
    <dbReference type="EnsemblBacteria" id="BAJ63389">
        <property type="protein sequence ID" value="BAJ63389"/>
        <property type="gene ID" value="ANT_13590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13590"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_9_0_0"/>
    <dbReference type="OMA" id="FCERNWP"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019365">
        <property type="term" value="P:pyridine nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044717">
        <property type="entry name" value="NIC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47297">
        <property type="entry name" value="PTHR47297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="236" mass="26338" checksum="CA7B8D22800E441C" modified="2011-04-05" version="1">MTTQSPSVQWAEWQAYLDEWLAGLSVVQAREVFEKPQKCAIVSVDVINGFCAFGPLASPRVARIVQPIVDLFQKAWSLGVRHIVLTQDTHEPDAVEFAQWPPHCVRGTAEAEPVDEFKALPFFSSMVQIPKNSIHSGLNTPLNDWIQAHPEVDTFVVVGDCTDLCTYQLAMHLRLDANARQLNRRVIVPVDCVDTYDLPVEVARVQGLMAHPGDVFHGIFLYHMALNGVEVVQKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S3</accession>
    <name>E8N4S3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559819.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14090"/>
    <dbReference type="EnsemblBacteria" id="BAJ63437">
        <property type="protein sequence ID" value="BAJ63437"/>
        <property type="gene ID" value="ANT_14090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14090"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1270122_0_0_0"/>
    <dbReference type="OMA" id="IEYEPHA"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="217" mass="23327" checksum="E4339613B5DFBE06" modified="2011-04-05" version="1">MPVGYQLIMRSGPQAGGVFPLTKTEISLGRDLTNDLVVSDPEVSRHHARLYLQGNTYVLEDLGSTNGTFVNGIRLTGPYPLRPGESISLGERVVFLYEVVDEDATVVTPASRIPAGGELYPQVGVSPSVGKAQSSVPSRPRYTAPLGSTPVAPVEYAVEPTSIEEPGLHQQNKTTRVLLISLAVVFVLACLCIGVLLWNAPKEFWCLFPIWPAGACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T6</accession>
    <name>E8N4T6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63450">
        <property type="protein sequence ID" value="BAJ63450"/>
        <property type="gene ID" value="ANT_14220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14220"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_0"/>
    <dbReference type="OMA" id="DIQMVAQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="14798" checksum="3C07949CA6E13001" modified="2011-04-05" version="1">MDQEKRMKILIIDDDPGMTDLLSVLLAPSGAETLVANTALDGLELARFGQPDVIILDLLMPEMNGVEVCKKIREFSAVPILVVSALDSPKVIAQVLDSGADAFLSKPISSAILMAQINKLLRRASLVKKSLTKPGLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N519</accession>
    <name>E8N519_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ordered locus">ANT_15050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63533">
        <property type="protein sequence ID" value="BAJ63533"/>
        <property type="gene ID" value="ANT_15050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15050"/>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_3_0_0"/>
    <dbReference type="OMA" id="EMSFLDH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="238" mass="26874" checksum="79DECB2E622679FA" modified="2011-04-05" version="1">MKEDERMAADKEMAIWDHINELRSRLLKALFSLIVTTLLSFMFSQYAIEILARPIGGIKNVVSIEVTENVGVFMRVSLLSGFILALPYILYQIFAFIVPGLLPHEKRILFTVIPIASILFISGVAFSYFVMLPAAIPFLVSFLGVQSFIRLSNYINFVTNLMFWIGVSFETPLIVFVLAKFKIVNSRMLLAQWRYAIVIIAVIAAMITPTVDPVNMGLLMAPLFALYLLSVFFARFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N583</accession>
    <name>E8N583_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N_BRCA1_IG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63597">
        <property type="protein sequence ID" value="BAJ63597"/>
        <property type="gene ID" value="ANT_15690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15690"/>
    <dbReference type="HOGENOM" id="CLU_1145363_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="N_BRCA1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="N_BRCA1_IG" evidence="2">
        <location>
            <begin position="144"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="26991" checksum="ACFC247F03AE3CA1" modified="2011-04-05" version="1">MHRRHHSHFCIIDKNMTRDKIMKNSIWDILTMILLLGIVIVAVGVLMLFQNPYLVFNPFPPPPPVPTIFVPSFTPTPKSLPPTWTPTAFPTLISEATKRPTSTPLPTNTPFVLPSPTPILKTVYPTNARLPLEGKCKVLAQSPEDGKTIKAGETFRVSWTLQNTSTEPWRSDSIDVRFKGGVPMHTSKDVIDLPKSVEPNGTIDITITMTAPEKAGYQITYWTLSAGSTVKCTFYVEIFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N597</accession>
    <name>E8N597_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63611">
        <property type="protein sequence ID" value="BAJ63611"/>
        <property type="gene ID" value="ANT_15850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15850"/>
    <dbReference type="eggNOG" id="COG4745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466647_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="584" mass="65694" checksum="9AF1767CDC54A3A3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A4</accession>
    <name>E8N5A4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15920"/>
    <dbReference type="EnsemblBacteria" id="BAJ63618">
        <property type="protein sequence ID" value="BAJ63618"/>
        <property type="gene ID" value="ANT_15920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15920"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_3_0_0"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="272" mass="30374" checksum="1772E5DDBA670CEA" modified="2011-04-05" version="1">MDNDKIIDMAKVRLDILLVQRGLAESRTVAQRLILAGRIRVSNEIVTEPSRRVEEDVPLNIDSGPKYVSRGGEKLEAALSAFGLDQLSEFVCADVGASTGGFTDCLLQHGARKVYALDVGYGILHWRLRQDPRVVVMERTNARYVEVLPEPVNLVTVDASFISLRILLPVIKRWLFPQYGHVIALIKPQFEAGREEVSRGEGVIRDSNVHQRVLKEVLCSAVEMGYEVKGLIQSPLRGPKGNIEFLTHLVPGDKQDTEIDWLVHSLFSQLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C0</accession>
    <name>E8N5C0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_16080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560014.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16080"/>
    <dbReference type="EnsemblBacteria" id="BAJ63634">
        <property type="protein sequence ID" value="BAJ63634"/>
        <property type="gene ID" value="ANT_16080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16080"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705239_0_0_0"/>
    <dbReference type="OMA" id="ENWSIER"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="391" mass="41972" checksum="BF590E182607838F" modified="2011-04-05" version="1">MPTNILLVAISLFFWGIGEGLFSYFQPVYLQQLGASSVKIGVIYGALGIAMTIAQAPAGFLADKIGNRPVMWASWVLGSASAIVMAFAMTENVFIAGMLLYGLTSFVIAPMNAYITSVRENWSIERALTTTAIAFNLGMIVGPKLGGIIATASGIKSIYQYSAGLFIISTLIILFAKKPSETETHPETQKSPKLIANRKFFVLLTSIGISTFAMYLPQPLTPNFLSNEAGISIGDLGNLGTIASLGNVLMAMIFGGLKGPDGFLVGQILGMIFAFSFWQGQSVYAFALGYLFMGGFRLMRLMGLAFARTLVQANETGTAYGLIETANGLAAFFAPTVAGFLYQQSPKGMYLYTLILISVVFLINLVLRLTFLRPQSGTIVTSSTSVSENLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C4</accession>
    <name>E8N5C4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560018.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63638">
        <property type="protein sequence ID" value="BAJ63638"/>
        <property type="gene ID" value="ANT_16120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16120"/>
    <dbReference type="HOGENOM" id="CLU_1821395_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="141" mass="15983" checksum="64C0FF79F78852B0" modified="2011-04-05" version="1">MSYTQTPPKTDREFLHQKQVRQQIFLPLVIVLLFILALMGLSILGAFQEGDLIHHLGNISSILLISPLILANLINLFLLIIGVRAINHLLRKLPFWMEHTQQTFQKIEEKTQSLCNALVSPLIKINSHLSTLGTLKKKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E8</accession>
    <name>E8N5E8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_16360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560042.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16360"/>
    <dbReference type="EnsemblBacteria" id="BAJ63662">
        <property type="protein sequence ID" value="BAJ63662"/>
        <property type="gene ID" value="ANT_16360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16360"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022305_0_1_0"/>
    <dbReference type="OMA" id="SAAMGGC"/>
    <dbReference type="OrthoDB" id="225730at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="144"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="410" mass="44513" checksum="C45E4FF30C4C67AF" modified="2011-04-05" version="1">MKSIRELYRIGHGPSSSHTMGPRRAAEIFRRCNPTAEKFRVVLYSSLAATGKGHLTDVAIREALSPLPVEFLWCPDQQLPLHPNGMEWFALGKGDEILSRWVVYSSGGGTLRAEGEPIEESPDIYPLTTLQEIMKECIRYGKTFWEYVIEIEGNELWEYLREVNRVMHQAIQRGIDTEGVLPGGLGLPRRAWNFYRKISLSGGYLVKEGYMPAYALAVAEENAAGGLVVTAPTCGSSGVLPAVIKHIEDTIPTTEPQVLRAIATAGLIGNLVKENASISGAEVGCQGEIGTACAMAAAAAAQLMGGSVRQIEYAAEMGLEHHLGLTCDPVNGLVQIPCIERNVFAATRALDCATFACYSDGNHRVSFDEVVHVMKQTGHDLPSLYRETAVGGLATAYRVPPKKLESSTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I1</accession>
    <name>E8N5I1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moeA</name>
        <name evidence="9" type="ordered locus">ANT_16690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63695">
        <property type="protein sequence ID" value="BAJ63695"/>
        <property type="gene ID" value="ANT_16690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16690"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_2_0"/>
    <dbReference type="OMA" id="MTGAMVP"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="190"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="412" mass="44410" checksum="C0C00598BCAEF712" modified="2011-04-05" version="1">MMNSLISVQEAQERILRFFDTLPIETIALENALGLVLAEDIHAPFDLPPFTSSSMDGFALRSEDIRTASPENPVTLRVIQDIPAGTFPNIPVLPGEAARIMTGAPIPMGVDCVVPVENTNAFNLKGTGLPDTVQIVSPVAPGQYLRPKGQDLQTGDVVLRAGTQITPQDIGLLASMGKTEVRVYPRPQVILFSSGNEIVPPASPLEPGKIYDSNLPMLTAMLKANGAVAVPLGTLRDDPQEILKSLERATQQKPAFILTSAGVSVGTYDFVRKVVEENGSLDFWRVNMRPGKPLAFGFFRDVPFIGLPGNPVSSFVGFTVFVIPVLRKLMGFPPSPPPTFTAILEENVESDGRESYLRGNVIFTPTGYRAHLEGHQGSGNLASLSKANALLILPSGVKSLPAGTEVKFWFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K9</accession>
    <name>E8N5K9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560102.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63723">
        <property type="protein sequence ID" value="BAJ63723"/>
        <property type="gene ID" value="ANT_16970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16970"/>
    <dbReference type="HOGENOM" id="CLU_2748940_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="70" mass="7841" checksum="C727ED71E4F797EF" modified="2011-04-05" version="1">MLNLFSRLLDRLSEFLASRKGLLPLIGMLLIFLNLLFSIFAPSGWLAQTDLLLHIGIILAIFGIMLAWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5M1</accession>
    <name>E8N5M1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">ANT_17090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17090"/>
    <dbReference type="EnsemblBacteria" id="BAJ63735">
        <property type="protein sequence ID" value="BAJ63735"/>
        <property type="gene ID" value="ANT_17090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17090"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_4_2_0"/>
    <dbReference type="OMA" id="TQVKYTP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="12">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="13">
        <location>
            <begin position="237"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="CbiA" evidence="11">
        <location>
            <begin position="381"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ63735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="604" mass="66776" checksum="778CCC53F91ED63C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5M2</accession>
    <name>E8N5M2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17100"/>
    <dbReference type="EnsemblBacteria" id="BAJ63736">
        <property type="protein sequence ID" value="BAJ63736"/>
        <property type="gene ID" value="ANT_17100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17100"/>
    <dbReference type="HOGENOM" id="CLU_2955169_0_0_0"/>
    <dbReference type="OMA" id="DETYFIC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="62" mass="7131" checksum="5D35BBBFA528A6D8" modified="2011-04-05" version="1">MVEAKQQCVFCGLDHRTVPLITLQYRDETYFICPQHLPVLIHNPQLLVGKLPGVENLEGYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P2</accession>
    <name>E8N5P2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PGA_cap domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_17300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17300"/>
    <dbReference type="EnsemblBacteria" id="BAJ63756">
        <property type="protein sequence ID" value="BAJ63756"/>
        <property type="gene ID" value="ANT_17300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17300"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495809_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228676" description="PGA_cap domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="4">
        <location>
            <begin position="250"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="549" mass="61300" checksum="185B8324CED5162E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q5</accession>
    <name>E8N5Q5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560147.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63769">
        <property type="protein sequence ID" value="BAJ63769"/>
        <property type="gene ID" value="ANT_17430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17430"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_0"/>
    <dbReference type="OMA" id="YCICSNA"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="219" mass="24762" checksum="FB29F2383349186A" modified="2011-04-05" version="1">MTIEALIFDLDGLLIDSERLSQRSWSQVMAEAGYLLSEDIYHQMIGRTEKDVKAILKQAFGNNFPFEDMYRKREQRFFEIIEQEGMPRKAGWDELAQYILQNGLRTAVASSTYRRLAEKKLSAARLLSFFEVIVTGDEVSHGKPAPDLFLTAASKLAIPPEKCVVLEDSEAGIQAAYNAGMKCIHIPDIQPISPQTLMLVWHQVSSLAKVREILEKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R2</accession>
    <name>E8N5R2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63776">
        <property type="protein sequence ID" value="BAJ63776"/>
        <property type="gene ID" value="ANT_17500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17500"/>
    <dbReference type="eggNOG" id="ENOG5032ZJK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138593_1_0_0"/>
    <dbReference type="OMA" id="CPIHCYK"/>
    <dbReference type="OrthoDB" id="1870180at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020483">
        <property type="entry name" value="Uncharacterised_YgbA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11756">
        <property type="entry name" value="YgbA_NO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="128" mass="15030" checksum="8B95257E6230D720" modified="2011-04-05" version="1">MVRLARWEVSMHPRIARERKTILAMSRIYCADHHGLPDGNLCMECQELLDYAFFRLEKCPYQEKKPTCANCPIHCYKPEMRERVRRMMRHAGPRMLLRHPILAIAHLLDGRKKVLPPGKGISVKERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T1</accession>
    <name>E8N5T1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560173.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63795">
        <property type="protein sequence ID" value="BAJ63795"/>
        <property type="gene ID" value="ANT_17690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17690"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_6_1_0"/>
    <dbReference type="OMA" id="QYSGDHY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="159" mass="16848" checksum="AA65AFCCD750409E" modified="2011-04-05" version="1">MAEFSRYEIYILLNQPKPLWLSHIDLSGMDLRGVMLSGATLIGANLSNVDLRGAVMVDANLGGANLRNAVLIGADLRRAHLRGADLRGADLREANLAEADLSEANLTGANLIDANLGAVDLTNANLTDADLTGTNAPDHRLLRAKSLAGTIMPDGQKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T8</accession>
    <name>E8N5T8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560180.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17760"/>
    <dbReference type="EnsemblBacteria" id="BAJ63802">
        <property type="protein sequence ID" value="BAJ63802"/>
        <property type="gene ID" value="ANT_17760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17760"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097071_0_0_0"/>
    <dbReference type="OMA" id="DDMTPNN"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="248" mass="28000" checksum="25BDB7F44E61BCFC" modified="2011-04-05" version="1">MSTFIRAEFHIHTVLSPCADIEMIPPLIVEQALSRNIHLIAITDHNHTANIEAVQKAAEGTPLKVLPGMELQTSEEVHVLCLFEKLEQAKAFQKIVDEHLPNLENNIDFFGEQFVVDETGDFLRREERLLLTSTSLNLHQAWEEVQALGGLFIPAHVNRKAFGLLPTLGMIPLDTPIEIVEISRDLPKEKVCELYPQICSTPFIQSGDAHFLDDILGWNHLWIPEISLKEISLAIQSLSPQRHQIISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V4</accession>
    <name>E8N5V4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_17920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560196.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17920"/>
    <dbReference type="EnsemblBacteria" id="BAJ63818">
        <property type="protein sequence ID" value="BAJ63818"/>
        <property type="gene ID" value="ANT_17920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17920"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_2_0"/>
    <dbReference type="OMA" id="NICTHGH"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="112" mass="12403" checksum="DB13FB86216C5A15" modified="2011-04-05" version="1">MMKEEPNVEFLQIVEQSELPPGERLFVEVEGVPIVLFNVGGEFYAIGDVCTHDDGPLGEGELDGYCIRCPRHGAKFDIRNGKALTLPAVEDTLSFPVRVVNGWIELGFPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N630</accession>
    <name>E8N630_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4340 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560271.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63894">
        <property type="protein sequence ID" value="BAJ63894"/>
        <property type="gene ID" value="ANT_18680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18680"/>
    <dbReference type="HOGENOM" id="CLU_1425326_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="190" mass="20464" checksum="471D3BAB433D8B77" modified="2011-04-05" version="1">MIRRSTWVVFGIFVLVAVLVFFLTKTPNAPFSGSQTPEPTAVPRMIEGWTSEEITKATLIRAIGGTTELIRQGDGQWLNQGVGNVSAGKVEQLLSELLATRILTELPADYSLESLYLANPGQTIILEAETGKKLEIRVGGLTPTGNGYYVKVQDHAPIVVSRYAIEAVFQGFDAALPDTPTPPGITPVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N633</accession>
    <name>E8N633_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">ndk</name>
        <name evidence="5" type="ordered locus">ANT_18710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560274.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63897">
        <property type="protein sequence ID" value="BAJ63897"/>
        <property type="gene ID" value="ANT_18710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18710"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_0"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="152" mass="17020" checksum="B8CC7564F57F1495" modified="2011-04-05" version="1">MEQTFVLVKPDGVQRGLIGEVIARLERRGLKLVGAKFLHVSRKLAEEHYAVHKGKPFYEGLINYITSAPVMAMVWEGPNAVAVVRQTMGATRPYEAAPGTIRHDFGLTVSRNLTHASDSVENAIAEITLWFKPEELVSWGRDTDRWIFESNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N699</accession>
    <name>E8N699_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560336.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19370"/>
    <dbReference type="EnsemblBacteria" id="BAJ63963">
        <property type="protein sequence ID" value="BAJ63963"/>
        <property type="gene ID" value="ANT_19370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19370"/>
    <dbReference type="eggNOG" id="COG5653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046277_1_0_0"/>
    <dbReference type="OMA" id="AWLHSWW"/>
    <dbReference type="OrthoDB" id="1856290at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="180"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="343" mass="40540" checksum="E816F79CCE27CE93" modified="2011-04-05" version="1">MNLEFDCHSSFSPQLIREWSELLPKSTCHVPFLDPDYLAIWWETRGGGEWQEECQLVLITARYQGQLVGIAPLFYTPDFRGCPRLMLLGSVEVSDYLDFVVLPEYLADFCEQLLPFVRQLSLPQWEMLDLYNLFETSPTLQALTQTAQRMGGSTQTERAYRCPQILLPGDWEQYLATLDKKQRHEVRRKIRRLEASGFNTRWYRVEDGKHLEEEINAFIQLMEFDEAKKRFLTPPMRQFMKQVIRWAHQKGILHLAFLEIDGIKAAAYLAFDMLNRLWIYNSGINPGFWDFSPGWVLVAYQLQWANEHHREAFDFMRGDEEYKYRFGAVDRFLDRLIITLPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A0</accession>
    <name>E8N6A0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63964">
        <property type="protein sequence ID" value="BAJ63964"/>
        <property type="gene ID" value="ANT_19380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19380"/>
    <dbReference type="HOGENOM" id="CLU_2986461_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="57" mass="6497" checksum="2BA0B5CB08D85940" modified="2011-04-05" version="1">MEVFMEGPANTLSYMLLGYGVIFGIMLIYLVSLAVRTRNLKQDEALLQELDKENSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A9</accession>
    <name>E8N6A9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative M28 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560346.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63973">
        <property type="protein sequence ID" value="BAJ63973"/>
        <property type="gene ID" value="ANT_19470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19470"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607866_0_0_0"/>
    <dbReference type="OMA" id="CLENTIV"/>
    <dbReference type="OrthoDB" id="396098at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="129"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="450" mass="50490" checksum="A398D11F21D5BC49" modified="2011-04-05" version="1">MALHSFFYRLFYVIAFFTFLLLPVSPGAITRNIPVQDLPLCTVSPEVSQILSLTSKENWSRWIRQLSGSEAVQIRGENYRITTRYSSALFSGNIHAQAYEYIRQWLLLWYPKEWIAEQSFQFSGETWKNLILTIPGSAHPEEFLLATAHLDSISPDPLRLAPGAEDNASGVATLLEMARIFRHYRFDRTIRLIWFTGEEQGLIGSKAYVRDYGTSGVAGVLNFDMFGYDQDGDGCFEIHTGTLPQSKPLGKCMVSLISAYNLNLKTDLIDGYNMTFSDHASFWETDIPAIEVLENHFYNAPTSGCAGKRDQNPNYHTIHDTIEEINLPVGFAIAQAGIATIASLAGVESPCFQQIPQLQVRVLQGLPHLEWTEVEHASHYRLLHAHPGCYSTGNMITETPLLHWEGSEEVFPLAGYMVEAISPEGCTSFPSHCVWASSAFQQKNPVPTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B2</accession>
    <name>E8N6B2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RfaH family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_19500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560349.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63976">
        <property type="protein sequence ID" value="BAJ63976"/>
        <property type="gene ID" value="ANT_19500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19500"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_5_0_0"/>
    <dbReference type="OMA" id="NQGVECF"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="178" mass="20365" checksum="DC5639231899C411" modified="2011-04-05" version="1">MSKKWYAIQSKPNKEQALCEQFQSRGIEVFYPQIRVNPVNPRARKIRPYFPGYLFVHVDLDEVGLSVIRWIPFARGVVSFSNEPASVPDNLIEAIRRRVDEVNRAGGELLETLKPGEPVLIQEGPFAGYEAIFDVRLSGKERVRVLIQLLSQRYIPVEMQVGSLKPLKTKNKDKPHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6F4</accession>
    <name>E8N6F4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative M50B family peptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_19920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560389.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19920"/>
    <dbReference type="EnsemblBacteria" id="BAJ64018">
        <property type="protein sequence ID" value="BAJ64018"/>
        <property type="gene ID" value="ANT_19920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19920"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_1_3_0"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="120"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="364" mass="39836" checksum="39BB616B86B41165" modified="2011-04-05" version="1">MDVTVLIRGIGQILEFVLALGVLIFLHELGHFLFARLFKIEVLEFGFGLPPRMLKLFTWKGTEFTLNWIPFGAFVRPKGESDPSIPDGMAAASPWKRFFILLGGPLMNFLTGIAIFSLLYTLTGAPETQKVQIIQVNPNSPAEVAGLMPGDLVVSVEGTPIQSMQSLSEAIRSHLGEEVTLVVSREGKTLTLKATPRQNPPEGEGPLGIVMGNPIRSISVPESIPYALRDTANQAKTLISLPVLILRGEVSGEQTRLIGPVGMERVYREVRQMDVQAQQENPSNVPVRTLLLLASISIGLGVANLFPIPALDGGRILFLLPEIIFKKRIPPEQENLVNLIGFTALILLMIFITTQDIVNPIQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ4</accession>
    <name>E8MXJ4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560445.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20490"/>
    <dbReference type="EnsemblBacteria" id="BAJ64075">
        <property type="protein sequence ID" value="BAJ64075"/>
        <property type="gene ID" value="ANT_20490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20490"/>
    <dbReference type="eggNOG" id="COG3552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042261_2_0_0"/>
    <dbReference type="OMA" id="EPRHLWG"/>
    <dbReference type="OrthoDB" id="1121563at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011195">
        <property type="entry name" value="UCP010256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010256">
        <property type="entry name" value="CoxE_vWa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="463" mass="53699" checksum="08847EC7E57FF4DD" modified="2011-04-05" version="1">MERRIVQFIAALRASGVRISLAESADAFRAVEWLGVTNRETFRMTLRATLIKDSQDFPTFERLFPMFFQASAPPPFQNIFPGLTEAEAKMLTQALQFFNRRLREMLERLLEGKPLSPQDFQQLQNWFNLSQYSDLRYQNYLARQIENALQFPELRQGIQELVELLQQLGMNRRRVAQIQKALEENRRALQEQIQQFAGQQILQNMLENPPPKGSSSLIDRPFQSLTESDSRQLREEVRRMAAALRTRLALRLRRAKSGQFDPKATLRANLQHGSIPIELRYKDHILKPKLVLLCDLSTSMRYCAEFFLTFISMVRDQIRQSHAFAYIDHLEYISPEFERMAPQQAIPQVLRRMPPGHYNTDLGNALAGFVAEHMDLLDQRTTLIVLGDGRNNFNPPREDLFQTMARRAKTCVWLNPDPQALWGTGDSDMPRYLPFCDLAFQVSNLRQLSQAIDQILCNPVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK7</accession>
    <name>E8MXK7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560458.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64088">
        <property type="protein sequence ID" value="BAJ64088"/>
        <property type="gene ID" value="ANT_20620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20620"/>
    <dbReference type="HOGENOM" id="CLU_171854_8_2_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007047">
        <property type="entry name" value="Flp_Fap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04964">
        <property type="entry name" value="Flp_Fap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="48" mass="4958" checksum="958E50CE1974FBF0" modified="2011-04-05" version="1">MLLAAKEKGQGLVEYALILVLVAVVVIVILALLGPAIGNIFSNIVNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM7</accession>
    <name>E8MXM7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">fmt</name>
        <name evidence="11" type="ordered locus">ANT_20820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560478.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20820"/>
    <dbReference type="EnsemblBacteria" id="BAJ64108">
        <property type="protein sequence ID" value="BAJ64108"/>
        <property type="gene ID" value="ANT_20820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20820"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_2_0"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="205"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="305" mass="33535" checksum="5A74EF473275F3AC" modified="2011-04-05" version="1">MLPKVVFMGSPEFALPTLKALAEHYPVVGVVTQPDRPAGRGNMLTPPPVKVLAQQLGIEVFQPEKLRNPEAMEKLRTWSPDLIVVAAFGQILRQAVLDLPQFGCINVHASLLPRWRGASPIQAAILHGDIVTGVTIMKMDAGIDTGPILAQREVAIQPDDTAGSLSDRLAEEGANLLIEVLPEYLTGRLHPKPQPEEGATYAKMLTKEEGHLNFEESVHQLVNRVRAYHPWPSAYTFWNGQMLKIHRAQAVQDSQATLGKRKVIEGYPAIGASDGWLVLLEVQPAGKRAMDGKDFLRGARSWSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN1</accession>
    <name>E8MXN1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">efp</name>
        <name evidence="11" type="ordered locus">ANT_20860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560482.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20860"/>
    <dbReference type="EnsemblBacteria" id="BAJ64112">
        <property type="protein sequence ID" value="BAJ64112"/>
        <property type="gene ID" value="ANT_20860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20860"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_0"/>
    <dbReference type="OMA" id="LYRMRMY"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="185" mass="21074" checksum="631B490304E6B93B" modified="2011-04-05" version="1">MIDVNDLRKGVIFELDGQLMRVLEYSHHKPGRGNAVIRIKARNLKTGATIEKTFTSGDRVQDIRLDYHTVQYLYSDENFFYFMDVETFDQVPVSKELVEEYAGFLKENMEVKLTLYQGQPLDIELPTTVDLKVVYAEPAVRGDTATGVTKKVRVETGAEIETPIFVNEGDTIRVDTRTGTYVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ2</accession>
    <name>E8MXQ2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21070"/>
    <dbReference type="EnsemblBacteria" id="BAJ64133">
        <property type="protein sequence ID" value="BAJ64133"/>
        <property type="gene ID" value="ANT_21070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21070"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_1_0_0"/>
    <dbReference type="OMA" id="KEVFLEW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="186" mass="21856" checksum="DB77310CF54CA4FF" modified="2011-04-05" version="1">MSMSRRKASESSPEYPLLGFLYFQPLHGYDLHKRLESTLGEVWTLPQNQVYNILKRLECQGYITPISGESESHTPNKQVFTLTPAGKHHFETWLMTPTPGSSKALRMEFICRLFFATQISEDLYSRLIQEQYHEIHRSVEYLKKKMEACPAEQVFNRMGLDLRIRQLIATLEWLETFHQICEEQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ4</accession>
    <name>E8MXQ4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_21090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560505.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21090"/>
    <dbReference type="EnsemblBacteria" id="BAJ64135">
        <property type="protein sequence ID" value="BAJ64135"/>
        <property type="gene ID" value="ANT_21090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21090"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070574_0_0_0"/>
    <dbReference type="OMA" id="IGGGPFN"/>
    <dbReference type="OrthoDB" id="1896377at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="272" mass="29045" checksum="9324005359FABA17" modified="2011-04-05" version="1">MEALLALVVAIPIGVLGGLIGLGGAEFRLPVLVGIFKRSARDAVPINLAISLITLLSSLIIRLRVLHDFPYVSLLVPVGGLIFGGMVFAFIGAGWISQIPVHRLEALIRYFLIMIGILLLIEGLFSLPVGHLLRYSLWLQGIVGIICGAMIGIVSSTLGVAGGELIIPTLIFIYGIDVKLAGTASLMISLPTVATGIFRYFRKGLYRERKEWTTMIAPMGAGSVAGAILGGILMGMIPGQWLKVILGLVLIISALRMFVNHHQSQNKTAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS7</accession>
    <name>E8MXS7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21320</name>
        <name evidence="3" type="ordered locus">ANT_23970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="2">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560528.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21320"/>
    <dbReference type="EnsemblBacteria" id="BAJ64158">
        <property type="protein sequence ID" value="BAJ64158"/>
        <property type="gene ID" value="ANT_21320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64423">
        <property type="protein sequence ID" value="BAJ64423"/>
        <property type="gene ID" value="ANT_23970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21320"/>
    <dbReference type="KEGG" id="atm:ANT_23970"/>
    <dbReference type="HOGENOM" id="CLU_1736751_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="17187" checksum="FBE9D706AC98FECD" modified="2011-04-05" version="1">MIPKTRRERERGSSLAWTAAFLGLVLIPLLMLVGDGARLLYVRGRLAQATDAACEDVSWSISDRTTWQRIRDDRYLQNWYLVGRAQNTFYQMLEEKSAVKYSPSLSLRLDWENGQAECRAQARVPLMVTFGQEVTIRTAVNARMRFAGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT3</accession>
    <name>E8MXT3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21380</name>
        <name evidence="2" type="ordered locus">ANT_24030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="1">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560534.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21380"/>
    <dbReference type="EnsemblBacteria" id="BAJ64164">
        <property type="protein sequence ID" value="BAJ64164"/>
        <property type="gene ID" value="ANT_21380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64429">
        <property type="protein sequence ID" value="BAJ64429"/>
        <property type="gene ID" value="ANT_24030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21380"/>
    <dbReference type="KEGG" id="atm:ANT_24030"/>
    <dbReference type="eggNOG" id="ENOG5032YT2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177114_1_0_0"/>
    <dbReference type="OMA" id="HTMWVEL"/>
    <dbReference type="OrthoDB" id="1922535at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="99" mass="11481" checksum="0690D776B28D0F86" modified="2011-04-05" version="1">MSTLVNEIQQARAQSVRITEDMLVVELTDGRVISVPLAWYPRLWYGSESERAHFEIIGEGEYIHWPELDEDLSVSGILKGRRSLENPESLKKWLAKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW7</accession>
    <name>E8MXW7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21720"/>
    <dbReference type="EnsemblBacteria" id="BAJ64198">
        <property type="protein sequence ID" value="BAJ64198"/>
        <property type="gene ID" value="ANT_21720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21720"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052294_0_0_0"/>
    <dbReference type="OMA" id="ERIHMLM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="114"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="264" mass="29857" checksum="EC0AA01528831C42" modified="2011-04-05" version="1">MKRIQECLPEVPTDGAHRDTRIQYDNCVSNCPVCGGIGYVRAEVPLGDPRFGKIERCPNAAALDIQRMKADPRIGITERDFELSFENIRPVSPITQVVVDIKPLVLSRASKTPKGAFVLIVGTPGIGKSLFLRTVVAVAVSSGITGAYANLAYTLDDLRRAYDMPNAGEELEERFIWWQNLDILALDEFDKANSTPWARERIHMLMDARYRLAVEGRGLTLVASNSEPMDDYLMSRFRDQRVGRVYRLNGQDIRTRTRELKLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ5</accession>
    <name>E8MXZ5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrogenase maturation protease</fullName>
            <ecNumber evidence="2">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560595.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22000"/>
    <dbReference type="EnsemblBacteria" id="BAJ64226">
        <property type="protein sequence ID" value="BAJ64226"/>
        <property type="gene ID" value="ANT_22000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22000"/>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099037_4_1_0"/>
    <dbReference type="OMA" id="ANQAPEN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="165" mass="18023" checksum="793788E4E181F82F" modified="2011-04-05" version="1">MGIGNPLNGDDAAGVVAIQRLRIVLRRRGATEEGISGDASSFFQRKMVLIEANQAPENFTGLLRQISPQIVFLIDAAWMDCAPGTICVIPWQEMGGFSASTHVQPPSMFARYLTEQIDCQVFTLGIQPQSLEFGSPLTLPVQRSVNRLVRELSRSFSGNNVISQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY15</accession>
    <name>E8MY15_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_22200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64246">
        <property type="protein sequence ID" value="BAJ64246"/>
        <property type="gene ID" value="ANT_22200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22200"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_380247_0_0_0"/>
    <dbReference type="OMA" id="YCFGPHQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024018">
        <property type="entry name" value="CHP04083_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04083">
        <property type="entry name" value="rSAM_pep_methan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="443"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="798" mass="89206" checksum="D9D9B13ABE274058" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY35</accession>
    <name>E8MY35_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_22400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22400"/>
    <dbReference type="EnsemblBacteria" id="BAJ64266">
        <property type="protein sequence ID" value="BAJ64266"/>
        <property type="gene ID" value="ANT_22400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22400"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013148_1_0_0"/>
    <dbReference type="OMA" id="LYSGMAD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="664" mass="75847" checksum="90E810A025DE2565" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY90</accession>
    <name>E8MY90_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62035">
        <property type="protein sequence ID" value="BAJ62035"/>
        <property type="gene ID" value="ANT_00010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00010"/>
    <dbReference type="HOGENOM" id="CLU_3195432_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="45" mass="5326" checksum="D8B0FCED0EB2458F" modified="2011-04-05" version="1">MNLKTHSLYKFSNFIHKQEGLSTVFRKLSTIFVENEENAGFYIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE3</accession>
    <name>E8MYE3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558486.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00540"/>
    <dbReference type="EnsemblBacteria" id="BAJ62088">
        <property type="protein sequence ID" value="BAJ62088"/>
        <property type="gene ID" value="ANT_00540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00540"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274943_0_0_0"/>
    <dbReference type="OMA" id="LEYWVEA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTAD" evidence="1">
        <location>
            <begin position="98"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1163" mass="131637" checksum="4C8E0DA793E652C9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI3</accession>
    <name>E8MYI3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N_BRCA1_IG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558526.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00940"/>
    <dbReference type="EnsemblBacteria" id="BAJ62128">
        <property type="protein sequence ID" value="BAJ62128"/>
        <property type="gene ID" value="ANT_00940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00940"/>
    <dbReference type="HOGENOM" id="CLU_1248492_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="N_BRCA1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N_BRCA1_IG" evidence="1">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="221" mass="24146" checksum="310C241DC41D0D37" modified="2011-04-05" version="1">MPRKTVFFVLLLIVLMVGFSGCQSTPTPEPTMDPAVWTQTAVAAQTLEQGTQEALQTAQARLNVTPSPTLTSTPAPTRTATPTVTPTITLVPTRTSTPLPSATITNTPSPYTCRLVSQVPRDGSTIKPNTQFTVTWTVQNVGKVIWEDIGIDLVQMGGDKIAVQTIYDLPRTVKPGESVDLQVELKAPEATGYYRTDWKLAIVDQGFTFCPLYVDFWVSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK5</accession>
    <name>E8MYK5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560708.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64341">
        <property type="protein sequence ID" value="BAJ64341"/>
        <property type="gene ID" value="ANT_23150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23150"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061523_0_0_0"/>
    <dbReference type="OMA" id="GLTAMHS"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="369" mass="41097" checksum="9ECA9D4E79EB33C2" modified="2011-04-05" version="1">MSISIPYRVGIQQRVLPAYRAAFFDLLAQACEGGLSVFAGQPRPEEALGQPAVLRKAQHVQAHNLHLGSGRLYTCVQRNLFEWLGQWNPDVLIVEANPRYLSTPAAVRWMHAQHKPVIGWGLGAPPARGFWREVLRERFLRLFDALITYSHSGAEQYRRLGFPQERIFVAPNAVTPRPAEVPPEKPPSFSSGRPMVLFVGRLQARKRVDLLLRACAALPQPLRPRLIVVGEGPERGTLEALANSLYPETLFVGEKRDEELEPYWQMADLFVLPGTGGLAVQQAMAHALPVMVAEADGTQEDLVTPLNGWRLIPGDLDDLTHRLAEALSQPERLREMGRASFRIVAERVNLDEMVAVFAQAMTTVMRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYL4</accession>
    <name>E8MYL4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD_synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_23240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64350">
        <property type="protein sequence ID" value="BAJ64350"/>
        <property type="gene ID" value="ANT_23240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23240"/>
    <dbReference type="eggNOG" id="COG1606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_0"/>
    <dbReference type="OMA" id="LVTRIPY"/>
    <dbReference type="OrthoDB" id="846643at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_synthase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="273" mass="30184" checksum="EE14A0EB2664605D" modified="2011-04-05" version="1">MGVNMDVSLQNKYQSLKTYLASLGSAVVAFSGGVDSGLVAVVAHQALGERMLAVTLQSPVETPDGVQAAIQVARQFGFPHRVMPYDDLEKHTFVENTPERCYFCKRERLGLLVELAKQAGFSAVLEGSNVDDLQDYRPGKRAVNELGVLSPLIEAGLTKDEVRALSRELELPVWNRPSAPCLATRFPYGMRITREGLERVARGEEFLKNLGFTLVRVRDYGTMARLEVSPEQVTELVARREQVHAFFRSLGYAHVAVDLLGYRSGSLNEGVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP7</accession>
    <name>E8MYP7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560749.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64383">
        <property type="protein sequence ID" value="BAJ64383"/>
        <property type="gene ID" value="ANT_23570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23570"/>
    <dbReference type="HOGENOM" id="CLU_1944225_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="129" mass="13881" checksum="58AF7B4B683EF019" modified="2011-04-05" version="1">MSDEPKPLDALTPEEPPSQPETGETETPELFTPPPLDASPEPYTAPSPEEAKAPEAPFAPPEPPPTQAPSTIPTPSPQKKGLAWWVIVLIVLVVLCCCCVATGLIGWGLYRMLEEQGVVSNLLLFIRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW8</accession>
    <name>E8MYW8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_24280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560809.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24280"/>
    <dbReference type="EnsemblBacteria" id="BAJ64454">
        <property type="protein sequence ID" value="BAJ64454"/>
        <property type="gene ID" value="ANT_24280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24280"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_0"/>
    <dbReference type="OMA" id="TKVTVEH"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="114"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="292" mass="32822" checksum="A2B0691B2B63DB19" modified="2011-04-05" version="1">MSDLEQFEVWLQEQDRSPVTVRGYMADLRAFAAWFEQTNGKALGVEEVTPADVREYRGWLQAVKRAGAATVRRHLMALRAYCRWGVETERIDRDPTARVKLPREETLSPGWLAKQEQYRLLREAERAVSAADTPTRRRLAVRDRALVVFLLNTGLRIAEACALTVEDVQIGERSGWVVVRGGKGNKSRKVPLNVEVRRALNAWREERGDGEGSVFDLTPSGAYRRLVEMGRRAGVEVHPHTLRHTLAKNLVDAGVGLHEVAALLGHSSLNTTRVYVTPGERDLERALQVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY2</accession>
    <name>E8MYY2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ordered locus">ANT_24420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560823.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64468">
        <property type="protein sequence ID" value="BAJ64468"/>
        <property type="gene ID" value="ANT_24420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24420"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_2_3_0"/>
    <dbReference type="OMA" id="INIVIWR"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="131" mass="14199" checksum="5229AEEF633D3113" modified="2011-04-05" version="1">MLEVQLIGNLGQDPEARYTAEGALVVSFPVAATRRWTDRDGQKHEETTWVDVTTWGGLAEVCHQHLTKGRQVFVRGRPEVRAFTRKNGELGAALRVTAEEVIFLGGKPGEKGVQAEAAGEAAPTSADDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY8</accession>
    <name>E8MYY8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">radA</name>
        <name evidence="9" type="ordered locus">ANT_00970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00970"/>
    <dbReference type="EnsemblBacteria" id="BAJ62131">
        <property type="protein sequence ID" value="BAJ62131"/>
        <property type="gene ID" value="ANT_00970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00970"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_0"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="8">
        <location>
            <begin position="74"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="361"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="468" mass="50272" checksum="ED7859393CC938A6" modified="2011-04-05" version="1">MIFMAKIQTRYVCQNCGRVAARAMGRCPQCGAWNSMVEEIIAPPSTPAKSPSASSSPGGFTSQPRRLDEIEGDHEARLPVPIGEFARVLGGGVVPGSITLVGGDPGIGKSTLMLQVALEMAQERRVLYISGEESERQVKMRAVRLLNGRPVPENLFLLTETNLDSMLEHVRSLAPSVLVVDSIQTVYLPALESSAGSVSQVRECASRLRDLAKSAGISIFVIGHVTKEGIIAGPRVLEHIVDTVLYLEGDRYQSYRLLRSVKNRFGATSEVGVFEMLERGMSEVLNPSEAFLAERLVNVPGSAIAVTMEGTRPLLVEIQGLTSPSPLTLPRRTPNGIDGNRLLLITAVLTRRLGMRLAEQDVFVNVIGGLRITEPAADLAVAAAIASSMKDTPVRANAVLIGEVGLSGELRMPSQMSARLREAAKLGFDTAIIPRRIRKGGEAYPEGIQVLEARSLREALNLALLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY9</accession>
    <name>E8MYY9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558530.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00980"/>
    <dbReference type="EnsemblBacteria" id="BAJ62132">
        <property type="protein sequence ID" value="BAJ62132"/>
        <property type="gene ID" value="ANT_00980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00980"/>
    <dbReference type="HOGENOM" id="CLU_2204572_0_0_0"/>
    <dbReference type="OrthoDB" id="2184793at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="107" mass="12217" checksum="BF2E2C6CF0560178" modified="2011-04-05" version="1">MEKAPRKVDAVVEAVHYTPEGKIDFVRLHERRGAVFGDHILVRREDLMQRLRAKQVIYSGRRLAPWGNQFEFGAPLRLVNHNGGEWVRCGEDDSAEARDLLKGVPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYZ5</accession>
    <name>E8MYZ5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558536.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01040"/>
    <dbReference type="EnsemblBacteria" id="BAJ62138">
        <property type="protein sequence ID" value="BAJ62138"/>
        <property type="gene ID" value="ANT_01040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01040"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073844_0_0_0"/>
    <dbReference type="OMA" id="LRSAKNW"/>
    <dbReference type="OrthoDB" id="1989297at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="313" mass="35608" checksum="1357EAE0B6716900" modified="2011-04-05" version="1">MLADLNRQLLETAETLRRKTALIKEKQTLENTLQRLRREVDDLETRTRQIRARLQALEGTSLQAGWHSLLGDRDEQITSARQELQSLEGQIKKAQRAVEETEARLLGLDAQLKSLAGMEERLENLLRQKEQALMSSQHPLGGELQALYRRQSDLRAEKREVGEALQIGLNALDRLKEAIAALESASGMGVWDMLGGGALISAFKHSRLNDARAALEQAQAALNHFARELRDVQVSREPALEMGGFELFFDVIADGLLVDWWVQSKISTALKHTRDQHDALIAALNHLNQRYRQLEQEEEHLRQRRQEILRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ11</accession>
    <name>E8MZ11_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62154">
        <property type="protein sequence ID" value="BAJ62154"/>
        <property type="gene ID" value="ANT_01200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01200"/>
    <dbReference type="HOGENOM" id="CLU_453204_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="602" mass="65724" checksum="9ED0404CE7AF6868" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ84</accession>
    <name>E8MZ84_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558625.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01930"/>
    <dbReference type="EnsemblBacteria" id="BAJ62227">
        <property type="protein sequence ID" value="BAJ62227"/>
        <property type="gene ID" value="ANT_01930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01930"/>
    <dbReference type="eggNOG" id="ENOG503283Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101335_3_0_0"/>
    <dbReference type="OrthoDB" id="1735899at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="17124" checksum="E0F8F389C83C30E9" modified="2011-04-05" version="1">MAIYRDAPYPPCHFTVDLGTGETWSPNTGLLEVVFPEARLVVADYRPGNSKTPEPQKVQTGVEYGTLILRRTVNGSLDWYQWWNEFRNGSTGNTRSVTIHLMNEDLSNVVLTWKFFRARPVNHLFSNLTGLGGELFVESLELAFERLEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ96</accession>
    <name>E8MZ96_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glpX</name>
        <name evidence="6" type="ordered locus">ANT_02050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558637.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02050"/>
    <dbReference type="EnsemblBacteria" id="BAJ62239">
        <property type="protein sequence ID" value="BAJ62239"/>
        <property type="gene ID" value="ANT_02050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02050"/>
    <dbReference type="eggNOG" id="COG1494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054938_0_0_0"/>
    <dbReference type="OMA" id="AVFYMDK"/>
    <dbReference type="OrthoDB" id="879338at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="35173" checksum="248CD57F4D9DA79B" modified="2011-04-05" version="1">MSASTPTRNLALDLVRVTEAAALAAGRYMGRGDKIAADRAAVEAMRWVLNSIEMDAVVVIGEGEKDEAPMLYNGERLGLGVPPELDLAVDPIDGTRPLAMGLWNSICTVALAPRGSMFNPGPALYMEKIAVGAEARDVIDLNAPVRDNLEKIARAKDERVEDLTVVILDRPRHEALIREVRACGARIRLIPDGDVAGALMTALPETGMDVLMGIGGSPEGVIAACAMRCLGGNLQGRLVARTPEEEIRLREQGYDLQRVLTLDDLVSSNDVFFAATGITSGDLLRGVDYFGNGATTDSLVMRGLTGTVRRIQATHRLDKLGRISPIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE7</accession>
    <name>E8MZE7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gatB</name>
        <name evidence="12" type="ordered locus">ANT_24690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560850.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64495">
        <property type="protein sequence ID" value="BAJ64495"/>
        <property type="gene ID" value="ANT_24690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24690"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_0"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="332"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="489" mass="54231" checksum="A38D210C811759B7" modified="2011-04-05" version="1">MGAYEAVIGLEIHAELLTRSKMFCSCPVVDSTKAKPNEAVCPICAGMPGTLPVINRQAVELALRVALALGCQINLVSIFARKNYFYPDLPKGYQISQYEQPLAVNGILPIETEAGWREIRIRRVHLEEDTGKLSHFSNDGEVYSLVDLNRAGVPLLEIVSEPDLHTAQEVRAYAQALRTLLRTLQASSGDMEKGALRIEPNISVRPAGSSVLGTRVEIKNLNSFRSLERAVAHQIEIQSAKLARGEAVEQETVGWDEIQEITFSQRSKEEAHDYRYFPEPDLPPLVLAPEWIESVRAALPELPWERQRRYVEALGLSSAEARLLVSDSALADFFDRTVQALRKASARMAATWVTGELLGWMNEQGQSLENLRISPEMLADLLDRAMDGQINLNTAKSVLQEMGASGKTAAEVIAEQGLEQVSDITWIAGVVAQVLQENPAELEKYRAGKQTLFNWFYGQVMRLMQGKANPQLVREELNRQLEGKNGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF5</accession>
    <name>E8MZF5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysulphide reductase, NrfD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_24770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24770"/>
    <dbReference type="EnsemblBacteria" id="BAJ64503">
        <property type="protein sequence ID" value="BAJ64503"/>
        <property type="gene ID" value="ANT_24770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24770"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021295_1_0_0"/>
    <dbReference type="OMA" id="WWVGIGH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="479" mass="55405" checksum="AA4CA25F0A1E996F" modified="2011-04-05" version="1">MAVEAKSLSTPLHGMDAEEAELREQLMFDPRPREELNRMVMESMVHTTPRYWAVVAFLAVVVLVCLFGAWGYMIATGIGLAGVRKPVYWGVFIVTFVFWIGISHAGTFVSAILRVFKAEFRRPFTRAAELMTTFGLAAGALYPLIHLGRVWVFYWMIPYPNARWLWPNFRSPLVWDFLAITTYLLSSTIYLYLPLIPDLAMARDRTQGWRHAIYKTLALGWRGTEAEWARLRKAITIFAFAIIPVMFSVHTIVSWDFAVSQTAVWNSTIFGPYFIVGAILSGVSAVVTILVILRATLKNMDYFIRMEHLDALGKLLLVFSMAWAYFFFNDYLVSWYGGYEAVRRVLFFHSSGPDSWIWWSMIIFNVLIPWLTLWNRRIRRTPWAMLIITLLINVGMYFERYTIVPMTLAHQRFPFDWGNYVPRIEIIISIGTLALFILLYMLASRLIPMVPVWEVREGQEAHMIRQIGKAKVPTVSELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG2</accession>
    <name>E8MZG2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative subtilisin family peptidase</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_24840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64510">
        <property type="protein sequence ID" value="BAJ64510"/>
        <property type="gene ID" value="ANT_24840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24840"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005356_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07474">
        <property type="entry name" value="Peptidases_S8_subtilisin_Vpr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034213">
        <property type="entry name" value="S8_Vpr-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="192"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="8">
        <location>
            <begin position="455"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1118" mass="117635" checksum="2A03D162059484B5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK3</accession>
    <name>E8MZK3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_25250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560906.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25250"/>
    <dbReference type="EnsemblBacteria" id="BAJ64551">
        <property type="protein sequence ID" value="BAJ64551"/>
        <property type="gene ID" value="ANT_25250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25250"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_44_1_0"/>
    <dbReference type="OMA" id="AFINGME"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="207" mass="23578" checksum="AA945E42E1BF4C9A" modified="2011-04-05" version="1">MAEKSSPRRTQAERRRASREKIIREASRLFAEYGYRGAKLAEIAQAVGMSEPGLLHHFPSKEHLLIAVLEERDRVDRERFGQDVLEERRNLLEGLRALVAHNETVPGLVQLFIVLAAESLQPDHPAHGYFSARYQQVRDSIVELLRQSQQRGEIRNDVSAEELAAMVVALMDGLQIQWLFHPEQVKMSAVFDAFLSLLKVKTPEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN2</accession>
    <name>E8MZN2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ordered locus">ANT_25540</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560935.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64580">
        <property type="protein sequence ID" value="BAJ64580"/>
        <property type="gene ID" value="ANT_25540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25540"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017729_1_0_0"/>
    <dbReference type="OMA" id="HNVRMRQ"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="UCP005047_YshC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="POLXc" evidence="20">
        <location>
            <begin position="7"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="18">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="19">
        <location>
            <begin position="344"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="BAJ64580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="581" mass="65016" checksum="953610CD63C0AC95" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS2</accession>
    <name>E8MZS2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphorylase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560975.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25940"/>
    <dbReference type="EnsemblBacteria" id="BAJ64620">
        <property type="protein sequence ID" value="BAJ64620"/>
        <property type="gene ID" value="ANT_25940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25940"/>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_1_0_0"/>
    <dbReference type="OMA" id="MECASMA"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="73"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="255" mass="28384" checksum="45F78A52F0665386" modified="2011-04-05" version="1">MEHPYPILEFDPEPNAILNPHRPNCEPVESTRAVLCFFADILRESLEKGELRIIGMLGTEIGNNPIYLHESPERPPVIVIHPGVGAPLAVGFLEEILTLGVDKVMVCGSCGVLKPEIKVGDALIPVKAVRDEGTSYHYLPPSRSVTASPQAVQALESVCRAMGVPYRTTKTWTTDAFYRETPAKRARRVAEGCEIVEMEASALFALAQFRQVTLGQIVYGGDLVIPEGWDHRSWNHRRDARRLLYEIALETVRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY3</accession>
    <name>E8MZY3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02840"/>
    <dbReference type="EnsemblBacteria" id="BAJ62318">
        <property type="protein sequence ID" value="BAJ62318"/>
        <property type="gene ID" value="ANT_02840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02840"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1871098_0_0_0"/>
    <dbReference type="OMA" id="GRNGSEC"/>
    <dbReference type="OrthoDB" id="596223at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228517" evidence="1">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="160" mass="16706" checksum="FC4B353F9A0644B4" modified="2011-04-05" version="1">MQNMSRKMRWAWMALGFLILVGSISAFAAANIVPFTHLGEILRANTVNDFKPPECAALNLTNIVVGSGTLTGTNQNDLILASPFNDTVNGRNGSECILGGGGDDYLDGRQGNDVILGGPGDDTLIGGTGNDYLIGGPGYDYCEGGGGTDTFDPSCEIQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N000</accession>
    <name>E8N000_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trxA</name>
        <name evidence="5" type="ordered locus">ANT_03010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62335">
        <property type="protein sequence ID" value="BAJ62335"/>
        <property type="gene ID" value="ANT_03010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03010"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1522539_0_0_0"/>
    <dbReference type="OMA" id="AVYDRCP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="19347" checksum="6454EDD0121DF87B" modified="2011-04-05" version="1">MDRVELLRKIQKHPRPVIVEFWAPWCTPCKVMEPSLKQVAKEFQGKVDLWRYNADEHPELVRDLRIMGIPTVLGFNAQGEIFRRTGALPLAGVREAFTAALEGKKPEKHLSALERALRAGTGIVLLLVGWSMQMNWVFLTLGGIVLFSAVYDRCPIVQAIKPRLEALFKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N001</accession>
    <name>E8N001_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558733.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03020"/>
    <dbReference type="EnsemblBacteria" id="BAJ62336">
        <property type="protein sequence ID" value="BAJ62336"/>
        <property type="gene ID" value="ANT_03020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03020"/>
    <dbReference type="eggNOG" id="ENOG5032B3S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176022_3_0_0"/>
    <dbReference type="OMA" id="GPIDRGI"/>
    <dbReference type="OrthoDB" id="2089632at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="68" mass="7350" checksum="5428F6E31765990B" modified="2011-04-05" version="1">MSNWINESGLDRVIRVILGLVLLVLGWGGIVSGTLGVVFKILGFLPLLTGLIGFCPAYALFKFRTNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N035</accession>
    <name>E8N035_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Prephenate dehydratase</fullName>
            <shortName evidence="8">PDT</shortName>
            <ecNumber evidence="3 8">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pheA</name>
        <name evidence="11" type="ordered locus">ANT_03360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="3 8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558767.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="SMR" id="E8N035"/>
    <dbReference type="STRING" id="926569.ANT_03360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62370">
        <property type="protein sequence ID" value="BAJ62370"/>
        <property type="gene ID" value="ANT_03360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03360"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_4_2_0"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="277" mass="30545" checksum="F082EC2F965A8284" modified="2011-04-05" version="1">MKVAFQGEPGAYSEAALLEHFGGQAQSLPCETFEQVFQAVAEGNARYGFLPIENSLAGSIHRNYDLLLQNDLYVVGEHHLRVSHCLIGLPGARLEEIESVISHPQALAQCDGTLRRLGVKTEPVYDTAGSVRLVQAEGNPRRAAIASRRAAQLYGMSILAEAIEDNPLNFTRFLIVAAEPVHPRGDAKTSIVFALQNAPGALFKALSVFALREIDLTKIESRPLVGKPWEYLFYIDLAGSTEETRVQNALHNLNEFATFLRVLGAYPRHRFTEPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N055</accession>
    <name>E8N055_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">engA</name>
        <name evidence="7" type="synonym">der</name>
        <name evidence="11" type="ordered locus">ANT_03560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558787.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62390">
        <property type="protein sequence ID" value="BAJ62390"/>
        <property type="gene ID" value="ANT_03560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03560"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_0"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="195"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="248"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="313"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="455" mass="50099" checksum="FD3583282BE0DDE9" modified="2011-04-05" version="1">MARSIVALVGRPNVGKSTLFNRLAGEPLAIVDDIPGTTRDRLFATAEWSGVEFDIVDTGGIDPSAARAGREPLSIGSAEFIKEIRSQAELAIQDADAILFLVDAISGLTPADREVAQILRRKQQMVDGKPYPPVFLVVNKADSANLRAVASEFYELGMGEPYPISALHGTGTGDLLDDLIASLPKVEEAGEDDSVKIAIVGKPNAGKSSLLNRLVGEERAIVSPIPGTTRDAVDTRIEYNGVPITLIDTAGIRRRGKIEPGVEKYSVLRSLRAIERSDVALLMIDATTGITAQDTHIAGFILEAWKSAVVLVNKWDAVEKDSHTMAEYTARLRHELNFMDYVPILFISAKTGQRVDQVLPLALRVQEERLARLNTGTINRLIQEAQERHAPVVRGGRSLHIYYGTQVRSDPPTFLLFCNDPKLAHFSYLRFLENVFRKEYPFTGTPIRFVLKPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N066</accession>
    <name>E8N066_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558798.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03670"/>
    <dbReference type="EnsemblBacteria" id="BAJ62401">
        <property type="protein sequence ID" value="BAJ62401"/>
        <property type="gene ID" value="ANT_03670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03670"/>
    <dbReference type="HOGENOM" id="CLU_2679641_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="74" mass="8310" checksum="DF5EAEB63822E6DC" modified="2011-04-05" version="1">MIKLKAWLESLAIFVLTLVLIAGASQSSLDRWERGVSARPFVEYAVMVAVSCLFLLALRRNPGEYGISLRNLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N074</accession>
    <name>E8N074_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_03750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558806.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03750"/>
    <dbReference type="EnsemblBacteria" id="BAJ62409">
        <property type="protein sequence ID" value="BAJ62409"/>
        <property type="gene ID" value="ANT_03750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03750"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_5_2_0"/>
    <dbReference type="OMA" id="EWTEILV"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228572" evidence="2">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="32"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="322" mass="34776" checksum="148D7982AFD631E2" modified="2011-04-05" version="1">MKKTLVFLFVLALMLSLLGCTPQATPTSQPATLKVVALPILDTMPILVAQQQGLFSKYNLTVEFIPAGSAPERDQLVAAGQADGMLNEVLSALYFNKESARVQVVRYARAATKDAALFTLVANPNSGVKSVADLKGKSVGISEGTIIQYVTERLLMAEGVDPKEVKLTSVPKIDARLALVKSGELDAAVLPEPLASVAVKEGSIAIISDAAYPQYSFSTWTFRKEVLKNNPDAVKRFLLALEDAVALINADPAKAEWKQLLVDNKILPAPLAENFVVPPFVTAGVPTEEQFMDTLTWAKEKGFLQADQAYQDVITASFLPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0A3</accession>
    <name>E8N0A3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative subtilisin family peptidase</fullName>
            <ecNumber evidence="6">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64652">
        <property type="protein sequence ID" value="BAJ64652"/>
        <property type="gene ID" value="ANT_26260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26260"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295230_0_0_0"/>
    <dbReference type="OMA" id="AKWESTT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04842">
        <property type="entry name" value="Peptidases_S8_Kp43_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034058">
        <property type="entry name" value="TagA/B/C/D_pept_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="P/Homo B" evidence="5">
        <location>
            <begin position="920"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1089" mass="116921" checksum="8EA0EA3F19553043" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B6</accession>
    <name>E8N0B6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26390"/>
    <dbReference type="EnsemblBacteria" id="BAJ64665">
        <property type="protein sequence ID" value="BAJ64665"/>
        <property type="gene ID" value="ANT_26390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26390"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309660_0_0_0"/>
    <dbReference type="OMA" id="YDFYNRF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="989" mass="112038" checksum="1DD701A86446048C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0C5</accession>
    <name>E8N0C5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561028.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26480"/>
    <dbReference type="EnsemblBacteria" id="BAJ64674">
        <property type="protein sequence ID" value="BAJ64674"/>
        <property type="gene ID" value="ANT_26480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26480"/>
    <dbReference type="HOGENOM" id="CLU_1068096_0_0_0"/>
    <dbReference type="OrthoDB" id="2159077at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="28537" checksum="511F294FE2758748" modified="2011-04-05" version="1">MGFLDEVNEPDLSLEPESSPPPRPSAPRRAASRRRSADGFWDGLTVLLLVGMAGMILYFFLIFQNPYASFNPYPPDTPVPTLFIPTFTPTPKVLPPTWTLTPTLEPTFTLTPSATVTETPTVTFTPAPPTDTPQVSAYRYLMRGSPDYLPGKVIHPDEGCKLWVAGQAFDLKGAPVVGITVQIGGSLDRPLYLLTLTGTAPQYGTGGYEFVLAEQALASTESVWVQLLDQEGYALSPRVYFNTYADCEKNLILVNFKQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I3</accession>
    <name>E8N0I3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_27060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561084.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27060"/>
    <dbReference type="EnsemblBacteria" id="BAJ64732">
        <property type="protein sequence ID" value="BAJ64732"/>
        <property type="gene ID" value="ANT_27060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27060"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="GRMPRWR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="249" mass="27134" checksum="11DB21FE05408866" modified="2011-04-05" version="1">MSNPIVSTQALTKVYGQGAAAVRALDGVNLTIQPGEFVAVMGPSGCGKSTLLHLIGGLDRPTSGTVWLDGQDLTQLNDDQVTSIRRKKMGFIFQFFNLIPVLNALENAALPMILDGMRPAEARKRAQEWLERVGLGHRLTHRPSELSGGEQQRVAIARALASDPALILADEPTGNLDSRASEEIAGLLRQISSTWERTILMVTHDARIAAYADRIVFLKDGKVVDETILEHRNGEQAEMVADKMKEIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I7</accession>
    <name>E8N0I7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Bacterioferritin</fullName>
            <ecNumber evidence="2">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bfr</name>
        <name evidence="6" type="ordered locus">ANT_27100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561088.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27100"/>
    <dbReference type="EnsemblBacteria" id="BAJ64736">
        <property type="protein sequence ID" value="BAJ64736"/>
        <property type="gene ID" value="ANT_27100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27100"/>
    <dbReference type="eggNOG" id="COG2193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_2_0_0"/>
    <dbReference type="OMA" id="YQRLFHV"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00549">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="2 3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="156" mass="17671" checksum="A43BEBB4616876F1" modified="2011-04-05" version="1">MKGKESVLKTLNALLADELTAINQYILHSEMCANWGFDRLHKVIEKRAIDEMKHAEKLIGRILFLEGMPVVSQLNPMHIGATVAEMLEKDHASEADAVKAYNQAVRLCVEEGDNGSRALLESILNDEEDHIDWLEAQLDQIRQMGLENYLSQQLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N2</accession>
    <name>E8N0N2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysE</name>
        <name evidence="7" type="ordered locus">ANT_03930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558823.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03930"/>
    <dbReference type="EnsemblBacteria" id="BAJ62427">
        <property type="protein sequence ID" value="BAJ62427"/>
        <property type="gene ID" value="ANT_03930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03930"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_0_0"/>
    <dbReference type="OMA" id="HPKIRHG"/>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="276" mass="30153" checksum="DCB5226FAE3CFFED" modified="2011-04-05" version="1">MVKKFFQMMREDIASVFERDPAARSVFEILVAYPGLHAVWGHRIAHWLWGRGFKTLARWLSHVMRFLTGIEIHPGATIGRRFFIDHGMGVVIGETAEIGNDVTLYHGVTLGGTSLEKGKRHPTLEDRVVVGAGAKILGAITVGAGSRIGANAVVVKSVPPNSVVVGVPGQVVVRNRPQTTAPDLNHNVLPDTIGTTVAALIERVESLEQRLEEARQQVQPALIGSSDRLERLEAVLRSHVLEHPHLVPGNGKEHHRHGPLPHPDASGVWHAEDFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P1</accession>
    <name>E8N0P1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_04020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558832.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04020"/>
    <dbReference type="EnsemblBacteria" id="BAJ62436">
        <property type="protein sequence ID" value="BAJ62436"/>
        <property type="gene ID" value="ANT_04020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04020"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OMA" id="FFAQKAF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="280" mass="31048" checksum="24E043438BC97121" modified="2011-04-05" version="1">MGKRVQTRLLDALTYLILLIGAVGMVTPFLWMVSTSFKLPADQFTKTLIPPTFTLRNFQALFAYGDISFPLLFLNSAVISLLTTIGQLLTCSMAAFCFAVVRFKGRDFLFTLLLLTLLIPFHVTLIPNFVIFSWLGLVGTSVPLWLPAFWGGAFGTFLLRQYFLTIPRDLVDAARVDGATLPQIYWKVYLPLAKPALAALAIFSFQGAWNDLLRPLVYMPAAPNTTLTVGLALFQTQMTRGGNFTVLMAGALISILPLLIVFFFAQRFFIEGIALSGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P7</accession>
    <name>E8N0P7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="10">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">metG</name>
        <name evidence="14" type="ordered locus">ANT_04080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558838.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62442">
        <property type="protein sequence ID" value="BAJ62442"/>
        <property type="gene ID" value="ANT_04080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04080"/>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_0"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="5"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="13">
        <location>
            <begin position="423"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ62442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="598" mass="68389" checksum="55F52ECDC9353188" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P8</accession>
    <name>E8N0P8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558839.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62443">
        <property type="protein sequence ID" value="BAJ62443"/>
        <property type="gene ID" value="ANT_04090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04090"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1363862_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="200" mass="22924" checksum="1CA647ED2D9D9180" modified="2011-04-05" version="1">MSELYLASMYLEQGDRENAARELERILSMDMDNIHAWRLLAHALTNPDEIRECWDNVLRLNPRDPEAIAALKALENRSAYMEGTPPPFPEEDMQALEKGMMPALEEEDAPSLEYRIATEATRPVTPRTGDEFAYLERNTQPRAEEKPEKGFFENDFIFYTLIFLVLLFIAIIAILVFFGPQAFDPLFQWLKSLGIPLGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q0</accession>
    <name>E8N0Q0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62445">
        <property type="protein sequence ID" value="BAJ62445"/>
        <property type="gene ID" value="ANT_04110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04110"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100236_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="159" mass="18131" checksum="84610F5CC9DEA44C" modified="2011-04-05" version="1">MNLPRHPLRVNVGFLLNAPVGYSRDIHFEFPLVQLEGDFLVSEFNGLLRVSRTPQGILSQCDFQGYTEVECVRCLSPFPQFVHTVFSELYAFNRRSLTESNLLFPENGYLELESLVREYLILEIPISPVCRPDCKGLCPVCGENLNLRLCEHSILPSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q1</accession>
    <name>E8N0Q1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_04120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558842.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62446">
        <property type="protein sequence ID" value="BAJ62446"/>
        <property type="gene ID" value="ANT_04120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04120"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_0"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="200" mass="21893" checksum="8B014898F79ED2D7" modified="2011-04-05" version="1">MTKLLIASTNRGKLREFQAILAGEPYELFLPADLGIALTVEETGETYRENAGMKARAYAQASGLITLSDDSGLEVQALNGAPGLHSARYAPQKGATDADRRAYLLENLRDKPRPWLARFVCTVAIATPQGEVFFTEGECPGEIIPEERGTHGFGYDPIFLFPERGLTMAELPPEEKNRISHRARAVLAAIPILRQLLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W1</accession>
    <name>E8N0W1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative basic membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_04720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558902.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04720"/>
    <dbReference type="EnsemblBacteria" id="BAJ62506">
        <property type="protein sequence ID" value="BAJ62506"/>
        <property type="gene ID" value="ANT_04720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04720"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_2_0_0"/>
    <dbReference type="OMA" id="PYTNMPD"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225375" evidence="2">
        <location>
            <begin position="28"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="47"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="403" mass="44376" checksum="29DE0965B09A0E94" modified="2011-04-05" version="1">MKNRVLLRAVALLVFVAILLGACQPSAATPEKVGEFQIPEIQKGKFNVAMVLIGPHDDGGWSQAHYEGLLYVEKNVPNVHVAYIENVPEGADSEQVFRALSRKGFNLIFGTSFGFMDPMETVASEFPNITYIHISGYKSNEKNFGNLFGAMETMKYLAGMLAGARAKMDGNPKLGYMATFPIPEELRLGNAIALGMRKTCPECTMDVRWINTWHDPVKEKEAAASLFDAGAQVVFTGADTPAVADVATEKGKWGVTYDWVGSCKAERCLTAPYWNWGPVYAKITQGVIDKTYKPGWDYFDADSGGLGLFGFMEGQTYPKGVAELPPEVINEVKDLVAKSLKGEFTRFDVFKGPIKDNTGKVIVPEGESLQQIDLDQFPEMGLGCKYCMKWWAEGITAELPQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z3</accession>
    <name>E8N0Z3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgP</name>
        <name evidence="12" type="ordered locus">ANT_05040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05040"/>
    <dbReference type="EnsemblBacteria" id="BAJ62538">
        <property type="protein sequence ID" value="BAJ62538"/>
        <property type="gene ID" value="ANT_05040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05040"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015112_0_0_0"/>
    <dbReference type="OMA" id="LYRHGYF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="732" mass="84801" checksum="99CF6E03A6410F1B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N135</accession>
    <name>E8N135_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561126.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27520"/>
    <dbReference type="EnsemblBacteria" id="BAJ64778">
        <property type="protein sequence ID" value="BAJ64778"/>
        <property type="gene ID" value="ANT_27520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27520"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426795_0_0_0"/>
    <dbReference type="OMA" id="AYQNIGS"/>
    <dbReference type="OrthoDB" id="1245649at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="641" mass="70767" checksum="27D044A49717A25C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C1</accession>
    <name>E8N1C1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64864">
        <property type="protein sequence ID" value="BAJ64864"/>
        <property type="gene ID" value="ANT_28380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28380"/>
    <dbReference type="HOGENOM" id="CLU_2520387_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="84" mass="9055" checksum="2032486ED1EDC3E7" modified="2011-04-05" version="1">MDTPRSGGAAETLAKGGWRACRASTPLDPFVDTPVRGARLRASTDFVNILLWINGTGPLIPLSQLLSHSFGFSFFACWDIASFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G7</accession>
    <name>E8N1G7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64910">
        <property type="protein sequence ID" value="BAJ64910"/>
        <property type="gene ID" value="ANT_28840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28840"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362762_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="770" mass="85518" checksum="9CB656D9BD08A6D9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P2</accession>
    <name>E8N1P2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_06130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559042.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62647">
        <property type="protein sequence ID" value="BAJ62647"/>
        <property type="gene ID" value="ANT_06130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06130"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718952_0_0_0"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228567" description="YkuD domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="246"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="384" mass="43301" checksum="C9760A5EDF17667F" modified="2011-04-05" version="1">MRKGLAVFFLAMLFWLAGTLSTVKAQSQSEPFTGDALCLPDAYPTGADCLVLGPAAKLTEWSAYGLTYPPRPLPARKPPAELTQSPVSIAKINLPANEPAPLYSTLEDAVNGSNPVRSIDAGKLRYVSIINVQRVNDKPYVQLKTGEWMRASPAAYSSFQGLQFYRTPANSFGWIVDHTRARTAPTYTAPEVDPILYRETAVQIYQIVNRDGTDWYQIGFDRWVERRYIRQVRINTTPPQGVTGNRWIEVNLYDQTLSVYENNQLIFATMVASGGEPFYTRPGLFQIYKKKPLETMQGAFEADRSDFYYLEDVPWTMYFDQARALHGAYWRAWYGFPGTHGCVNLSIGDSAWLFQWAKEGDWVYVWDPSGQTPTDPALYTQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T8</accession>
    <name>E8N1T8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_06590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559088.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62693">
        <property type="protein sequence ID" value="BAJ62693"/>
        <property type="gene ID" value="ANT_06590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06590"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_7_0"/>
    <dbReference type="OMA" id="GPFYDIR"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="154"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="300" mass="34197" checksum="73E2239CC23FF77C" modified="2011-04-05" version="1">MGKARLLIVEDDVDISNMLKIYFSSQGYDVETALRGSDALEKTRQNMPHLIVLDIMLPDINGYEVCRQLRTTTRTSHIPVIFLTQKDERSDRLQGLELGADDYITKPFDIDELRLRVQNAISRSERESLTDPQTGLPAGRMIEDQLRQVIRQPRGWAFLDVRINYFEPFKNVYGFIAGGDVLRFTSMLLGEVVDELGTQNDFVGHAGGDNFIIITAEDRAEAIKQRAKERFKEEVLTHYNFMDRQQGYILAPDEEGKIEPTPLMTLAVGVVSPATHYFADIREITELAAEERRKDAANER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1U5</accession>
    <name>E8N1U5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559095.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06660"/>
    <dbReference type="EnsemblBacteria" id="BAJ62700">
        <property type="protein sequence ID" value="BAJ62700"/>
        <property type="gene ID" value="ANT_06660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06660"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="OMA" id="LITETRY"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="108"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="37704" checksum="CCE9D87E1C06C749" modified="2011-04-05" version="1">MSKNYLRYFLNKLAWLLVTAIFAFILNFTLPRLMPGDPVAAITARIAQGMSNTTGMKEVYERYAEQFGTNKPIHEQFLIYMKNILQGNFGTSFSQYPRPVADIIRASIVWTVALQFPAIIVGWIIGNALGAMAAYLKKGFDKVLMPISIFVSNFPAFGMAIILMVIFAVNLKWFPTSGGYGFNLIPNFSWEFIWSVIVHYQLPFWSIVLIIIGGQAIGMRSMSIYELNADYVKYARFLGIKDRVIVRYVFRNAMLPQITGLALSIGTMVSGALVAEIVFSYPGLGYTMLNGVMGQDYPLISAVTLIITIMTLVANFAIEILYGIIDPRIKAAQTEQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Y8</accession>
    <name>E8N1Y8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_E_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561279.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64935">
        <property type="protein sequence ID" value="BAJ64935"/>
        <property type="gene ID" value="ANT_29090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29090"/>
    <dbReference type="eggNOG" id="COG3708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108864_2_0_0"/>
    <dbReference type="OMA" id="DERWIDD"/>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="154" mass="17523" checksum="2DAF736DBFAEC9A5" modified="2011-04-05" version="1">MNPEIVERPAFTVLGYRYQGKNEHQEISAMWEQFLPRMGEIRTTNPLESFGVCRMAPGLPPGEFEYIAGMEVEADHPVPEGMVKVTLPAARYAVFEHRGGLETLQDTFHKIAVEYLPNSGLTRVTPEVDIEVYDDRVFRGFSPESILYIYVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A7</accession>
    <name>E8N2A7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561395.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30280"/>
    <dbReference type="EnsemblBacteria" id="BAJ65054">
        <property type="protein sequence ID" value="BAJ65054"/>
        <property type="gene ID" value="ANT_30280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30280"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OMA" id="ISAQNHY"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="320" mass="36145" checksum="3771D8A7E79ABDCF" modified="2011-04-05" version="1">MEYRRLGNSGLKVARICLGTMQFGWTADEKTAFEVMDAYFEAGGNFIDTADVYSAWVPGNPGGVSEEIIGRWMKARKNRHLIVLATKFNGRMWEGPNGDGLSRGHVMKAIEDSLRRLQTDYIDLYQTHWPHYDTPQEETLRALDDLVKAGKVRYIGASNEPAWRLMKAMWISDKYNLNRFISLQPPYSLVKRAEFERELEAVCLDQGIGVIPYSPLQGGFLTGKYRRGVIPDSARAEGLKRFFTEKNFALIDLLDEIGKKHNATVTQVALAWMLQRPAITSPIIGANSVEQLRDILGSLEVELTAEDVAAIDQASEWREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J9</accession>
    <name>E8N2J9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_07710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559198.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07710"/>
    <dbReference type="EnsemblBacteria" id="BAJ62805">
        <property type="protein sequence ID" value="BAJ62805"/>
        <property type="gene ID" value="ANT_07710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07710"/>
    <dbReference type="HOGENOM" id="CLU_1060258_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="262" mass="28784" checksum="F2917696EFB2CA47" modified="2011-04-05" version="1">MSNIEEIEVVETSQKRWHWDWLWRIFLRPRQVFDQIAQTEVSTWLLPVLFLTVVSLVYVLVSGPTRTQELLAKPIEPPPDFQYWDPAMQEEYMKNAQPNPSPALIYVLPAVGAVVKVWLSWVILAALVHLALTLAGGRGSRSAEFSVAGWSLMPLAVREIVHLIAVLSAHQSIKNPGLSGFIQTETGGGAVFLASLLSFVDLYLVWQVVLLVLGAKRTSGLSTGKTLVSVLIAVILLLVLQALPGFIGAQLSGLQTGGFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L0</accession>
    <name>E8N2L0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559209.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07820"/>
    <dbReference type="EnsemblBacteria" id="BAJ62816">
        <property type="protein sequence ID" value="BAJ62816"/>
        <property type="gene ID" value="ANT_07820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07820"/>
    <dbReference type="HOGENOM" id="CLU_770835_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="359" mass="41677" checksum="523551BE5AAA924C" modified="2011-04-05" version="1">MPVSIPKLSQWTIFSGKWKVFWLILLLVPYLLYLSFVVMKGQGPIDYETFMDIGNRFLQGVEVYGENSYYPLPYVMIFAFFAALPRPISQILWHLLPVIVSLLISGWNPLILLYAPLFSHFTGGQTALFGLLGLWGYRKTPDPSQAKGGVWLALTFLKPQLAIFPFGYALWTWWKEWQSSRKIPRQAWAWLIAFVAIYLPSFFVTPDWPLRWLENPRPLAERAMSGFLPRTLLYFISWKTIFYWLVWGILAGMLFWLIWRLNGKRISLDLLVLWGFVISPLVHDYDLIQLIPLLEPLLVLLSALLASIPGLLTIILAYEVDKAWYTFTFIAPIILAGWLLYQNKFLRLRKSSPHGEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L3</accession>
    <name>E8N2L3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559212.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07850"/>
    <dbReference type="EnsemblBacteria" id="BAJ62819">
        <property type="protein sequence ID" value="BAJ62819"/>
        <property type="gene ID" value="ANT_07850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07850"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_3_2_0"/>
    <dbReference type="OMA" id="EIVLCNA"/>
    <dbReference type="OrthoDB" id="1282433at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="251" mass="28197" checksum="10A51E5600BA2D5F" modified="2011-04-05" version="1">MAGSAFYVPESVMAIVAHPDDIEFSCAGTMARWARAGARICYVLCTSGDVGIADLSLTREQAAAIREEEARKAAEITGVKEIVFLREPDGMLQPTLELRKKLVREIRRFRPEVVVTGDPTVVWAGEEYINHPDHRAASLAALEAVFPAAGQPHLFREIEQEEGFKAHKVRKVYATTWDHANLYVDITDTIEIKIEALRAHKSQMGDWDPADRIRQWAAERAKGKEMLYAESFRVVTLVDDQTWARICCGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P7</accession>
    <name>E8N2P7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_08190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559245.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08190"/>
    <dbReference type="EnsemblBacteria" id="BAJ62853">
        <property type="protein sequence ID" value="BAJ62853"/>
        <property type="gene ID" value="ANT_08190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08190"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_1_0"/>
    <dbReference type="OMA" id="HYSTIKM"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="69" mass="7725" checksum="2D42AA979AA28475" modified="2011-04-05" version="1">MSERIIGTVKWFNSEKGYGFISRENGPDVFVHYSAIEGNGYRSLNEGQTVEFKVEKGPKGLQASQVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2R3</accession>
    <name>E8N2R3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561404.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30370"/>
    <dbReference type="EnsemblBacteria" id="BAJ65063">
        <property type="protein sequence ID" value="BAJ65063"/>
        <property type="gene ID" value="ANT_30370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30370"/>
    <dbReference type="HOGENOM" id="CLU_2285559_0_0_0"/>
    <dbReference type="OrthoDB" id="2173668at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="101" mass="11786" checksum="A0F0C6AD1261629F" modified="2011-04-05" version="1">MSLFRDLFFKPYPASAHAEVTRLLDELVDIGKREDFLAERFTPGFNLQLRHIRAREIGERLNAIGGRALMEYAYRHVARKAGRVLADHLEYAWAEIGDWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2R9</accession>
    <name>E8N2R9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561410.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30430"/>
    <dbReference type="EnsemblBacteria" id="BAJ65069">
        <property type="protein sequence ID" value="BAJ65069"/>
        <property type="gene ID" value="ANT_30430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30430"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259169_0_0_0"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007280">
        <property type="entry name" value="Peptidase_C_arc/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04151">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="3">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1329" mass="143586" checksum="9225D106E8DE03BB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T5</accession>
    <name>E8N2T5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561426.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30590"/>
    <dbReference type="EnsemblBacteria" id="BAJ65085">
        <property type="protein sequence ID" value="BAJ65085"/>
        <property type="gene ID" value="ANT_30590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30590"/>
    <dbReference type="HOGENOM" id="CLU_2406927_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="101" mass="11440" checksum="89EB2698AA7DC8FA" modified="2011-04-05" version="1">MKQVRRVLGVWLLLNLMGLAVLALGWMALHDIFHDYVSPGVLAEAGVQASLPEWTQTSGEWSMVLVVWALLLALLALNVLMTGWLFLRRPFEERQDLPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T7</accession>
    <name>E8N2T7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561428.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30610"/>
    <dbReference type="EnsemblBacteria" id="BAJ65087">
        <property type="protein sequence ID" value="BAJ65087"/>
        <property type="gene ID" value="ANT_30610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30610"/>
    <dbReference type="HOGENOM" id="CLU_1891828_0_0_0"/>
    <dbReference type="OrthoDB" id="1930123at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225249" evidence="1">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="14786" checksum="D13309793CB883DA" modified="2011-04-05" version="1">MKKNRVQILIAALVLLLVTLACEFSASTAKIQEVWLSTDEAGEQRTTTFAPDAVFYAQVDLRNAPDDTSLKAVWTAVEVEGAEPNLVLAETDFTSGSGTVTFNLKNDQLWPAGKYRVEIYLNGKLDKTVDFEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V3</accession>
    <name>E8N2V3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561444.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30770"/>
    <dbReference type="EnsemblBacteria" id="BAJ65103">
        <property type="protein sequence ID" value="BAJ65103"/>
        <property type="gene ID" value="ANT_30770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30770"/>
    <dbReference type="eggNOG" id="COG4397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362824_0_0_0"/>
    <dbReference type="OrthoDB" id="436392at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="637" mass="69835" checksum="02622C0418A9102D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N340</accession>
    <name>E8N340_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M22 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561530.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31660"/>
    <dbReference type="EnsemblBacteria" id="BAJ65190">
        <property type="protein sequence ID" value="BAJ65190"/>
        <property type="gene ID" value="ANT_31660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31660"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_0_0_0"/>
    <dbReference type="OMA" id="PFYLKDF"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="224" mass="24308" checksum="22E34773735CD0EB" modified="2011-04-05" version="1">MSLLLAVDTSTQWTGLALYDGARVLGEMTWLTRGHHTVETAPAIQRLLEQSGARMEQIDCFAAALGPGSFTSLRIGLALVKGMALTLRKPIVGIPTLDFLAEALPVQEFPLAAVLQAGRGRLALVWYRAVKGRWKAQGEPQIITAAALAEQIQEPTLVAGELTPEERDLLKRKRGNVLLASPALSTRRPSFLAELAWERFQAGKVDDPISLAPIYLHVGEVIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C8</accession>
    <name>E8N3C8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1080 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559334.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62942">
        <property type="protein sequence ID" value="BAJ62942"/>
        <property type="gene ID" value="ANT_09080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09080"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188994_0_0_0"/>
    <dbReference type="OMA" id="YSFQYDP"/>
    <dbReference type="OrthoDB" id="1355454at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1080" evidence="2">
        <location>
            <begin position="64"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="226" mass="25164" checksum="FD547B206894091C" modified="2011-04-05" version="1">MVRRGYREQGQGLIEYALFVALLLVAVYLSLQAMGLSLRDAFTLVYCGISRSNACQTLFSDDFNNLNAWTIVRGIWKTQDGKLLAGPGEGRIFRDLPQKDYVISLNGAQLFQGNGYGIFFRATNPNAVNGYSFQYDPGYGGFIFRKWVNGSEISPPFAVAKAPSFDWYSQPRNIQLVVQGNTYIAYVDGVKVLEARDNTYTEGGMGLRTWDNSTISVDQVTVNSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E8</accession>
    <name>E8N3E8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_09280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559353.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09280"/>
    <dbReference type="EnsemblBacteria" id="BAJ62962">
        <property type="protein sequence ID" value="BAJ62962"/>
        <property type="gene ID" value="ANT_09280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09280"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_0"/>
    <dbReference type="OMA" id="SDCKKTW"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="315" mass="36057" checksum="26122A1D49250212" modified="2011-04-05" version="1">MHPYYKQYQWSNVFTMIHNLKLEPKICMDDCPHRLVVITGATSGIGHATARKYASHGADLILINRNQQKSEAICEELKREFQVNCSYFMADFSRLSDIHSTARHLVALERDIDVLVHNAGVYLTRKTITEDGLETVFQTNYLSTFILNYYLLEKFKAQNKGRIIFVNSEAYRFAVWGLDFDDLFWNKRRYSGIKSYGAAKLAQLLSMIVLDEYFQGTGVTVNAMHPGNVRTNSGQSNGWLYKKFKSLFIDRFARPIDDAAEALYYLGVSPEVENVSGKFFNLTTVEEPAPPALDRDAAMKLWKISMELGGFHEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L4</accession>
    <name>E8N3L4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559419.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09940"/>
    <dbReference type="EnsemblBacteria" id="BAJ63028">
        <property type="protein sequence ID" value="BAJ63028"/>
        <property type="gene ID" value="ANT_09940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09940"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099824_3_0_0"/>
    <dbReference type="OMA" id="WRIIGTG"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="167" mass="19159" checksum="B6151085FB547544" modified="2011-04-05" version="1">MHEPVLVLNANFEPIHVCDMRRAIGLLMSEKATMVVNGRGNILTVSRVIPRPSVIRLQKMISRPRPRLKLTRREVFRRDNYTCQYCGKHTTDLTVDHVIPRHLGGAHCWTNVVAACPACNHRKGGRTLEEAGMKLLRPPTEPPTSARYVFGRHLEENKEWEQFLTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3R6</accession>
    <name>E8N3R6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase chain M</fullName>
            <ecNumber evidence="6">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoM</name>
        <name evidence="6" type="ordered locus">ANT_10460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559470.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63080">
        <property type="protein sequence ID" value="BAJ63080"/>
        <property type="gene ID" value="ANT_10460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10460"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_0"/>
    <dbReference type="OMA" id="QSNMKRR"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="132"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="505" mass="55428" checksum="8E0049B884443ADE" modified="2011-04-05" version="1">MDFLGNHLLSLILFIPTGAALLLLLIPRDRLTLIRWFSLVASLIPLILSVILWFRFDPQGAKFQFVEEAVWYPAIHSSYHVGIDGIALTMVLLTTLLTPLAILASFSIQDNVRTYMVLFLLLETGMLGVFLALDLLLFFVFWEVGLVPMYFLIAQWGGANRNYASLKFILYTMAGSLGLLLAIQLIGVVTQTYDITRLIELWPSLDLPGGVLLGLPLSTVKAVAFWAFVVAFAIKVPVWPFHTWLPDAHTEAPTAGSMILAGVLLKLGAFGFIRLVLPLYPAESRQYALWLAGLATLAIIFGALGAFGQNDFKRLVAYSSINHMGFVVLGVAAMAIAPGTLDANIAMNGAVLQMFNHGLYSAGMFFLVGVIYERAHTRDLNAFGGLYALLPVYGSVLIFTSMASLGLPGLNGFVSEFMVVRGAWGVLTVFTALSMIGLFFTGAYTLKALWKVLHGPLNEHWKGHVSEMNVREMLVIAPLMALILVIGVMPGWIVDVINRAVRLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S4</accession>
    <name>E8N3S4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">F-type ATPase subunit b</fullName>
            <shortName evidence="15">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">atpF</name>
        <name evidence="18" type="synonym">atpH</name>
        <name evidence="18" type="ordered locus">ANT_10540</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="14 15">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">This fusion protein includes a component of the F(0) channel (subunit b) and of the F(1) subunit (subunit delta). Two copies of subunit b and one of delta together form the peripheral 'stator' stalk which links F(1) to F(0).</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 16">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559478.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10540"/>
    <dbReference type="EnsemblBacteria" id="BAJ63088">
        <property type="protein sequence ID" value="BAJ63088"/>
        <property type="gene ID" value="ANT_10540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10540"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127256_0_0_0"/>
    <dbReference type="OrthoDB" id="1937493at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 15 16" id="KW-0138">CF(0)</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 15 16" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAJ63088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="26752" checksum="2001768C9EDD2B55" modified="2011-04-05" version="1">MEALGINLGYLLVYIFSFAVVFITLRAWVFVPLSEMMEKRRKTIAQGLEDARIAAEARANAEKEAQSILADAQQKAAEIVREATLRAQKVEEEIRAQAEAEAGKARAQVMAELEGERNRMLSELRGQVGALAIAAAQKLIGENLDEKRQHALLNEFFAGVRGGKVVVLEGIESVVADHAEIVSALPLTEEEQELVKREVLSRLGSAAAVSFRVDPSILGGLIVRLGNRVVDGSLAGQLEGLRQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3T4</accession>
    <name>E8N3T4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559488.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63098">
        <property type="protein sequence ID" value="BAJ63098"/>
        <property type="gene ID" value="ANT_10640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10640"/>
    <dbReference type="HOGENOM" id="CLU_1318716_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228151" evidence="1">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="208" mass="23340" checksum="21396A35ED84CBF3" modified="2011-04-05" version="1">MKKKPLPQFLTAFSLSCLMLLASCQFPTEYFFAPNVPPPKQLGKTSVPSSTPVPSPTPVPTFTPTPIPCAFAWVNQPLEEETARLQDVLVKSGWSTVEGLLMAYGENCLDVSTNQVVRFTPLQTDFYFTVPVASIENQDELGFWAERLLQVAEQLPQNELPGMTRGYMSILFDNGQNQVRLWFPIEEGIKALENGLRGNALFQRLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N406</accession>
    <name>E8N406_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_11360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559558.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11360"/>
    <dbReference type="EnsemblBacteria" id="BAJ63170">
        <property type="protein sequence ID" value="BAJ63170"/>
        <property type="gene ID" value="ANT_11360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11360"/>
    <dbReference type="eggNOG" id="COG1371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111362_3_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="139" mass="15454" checksum="C02D416F91193D26" modified="2011-04-05" version="1">MASEPKTLMGFEEIEHTADWSLRVWAPDLPTFFKQAATGMLHLMGVESLDVPAVLSDLTVEGDDPEALLVAFLTEILFLLEKSKVPRSFHLKFEGTKLKAQLECVPLKSLAKEIKAVTFHNLSIQKQNGVLEATITFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N429</accession>
    <name>E8N429_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_11590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559581.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11590"/>
    <dbReference type="EnsemblBacteria" id="BAJ63193">
        <property type="protein sequence ID" value="BAJ63193"/>
        <property type="gene ID" value="ANT_11590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11590"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_0_0"/>
    <dbReference type="OMA" id="YGHERFA"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="10">
        <location>
            <begin position="5"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="389" mass="42894" checksum="C275596ADCBBF1C0" modified="2011-04-05" version="1">MTKTIGILTGGGDVPGLNPAIKSVAMGAFEMGYRVLGIRRGWGGLLNYNLDEPSTHDYYIKELTRDSVRTIDRTGGTFLHTSRTNPQKVSPKSTPDFLKNSKWGKPIKDSEDMDYTDYVMKVISHLGIDVLVPIGGDDTLSFAVRLHREGVPVVAIPKTMDNDVFGTDYCIGFSTAVTRSVEFITNMRTSVGSHERIGVIELFGRNSGETSLISAYLAYVDRAIISEVPFNIEKLANFLLEDKRNNPSNYAIMTISEGAIMEGGEIIESGEADAYGHRKLGGIGLITAEMIKKITGQNIMYQQLGYLMRSGAPDSLDRMVAMSFGNLAIQLIRRNETGKMVALHGGKYTTVPVEMVLAGKKRVDVASFYDIEQYRPRVKDFMGVPMFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N452</accession>
    <name>E8N452_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_11820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559604.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11820"/>
    <dbReference type="EnsemblBacteria" id="BAJ63216">
        <property type="protein sequence ID" value="BAJ63216"/>
        <property type="gene ID" value="ANT_11820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11820"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490630_0_0_0"/>
    <dbReference type="OrthoDB" id="994223at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="244"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="555" mass="62373" checksum="B7269240B1275D66" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N462</accession>
    <name>E8N462_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11920"/>
    <dbReference type="EnsemblBacteria" id="BAJ63226">
        <property type="protein sequence ID" value="BAJ63226"/>
        <property type="gene ID" value="ANT_11920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11920"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045984_0_0_0"/>
    <dbReference type="OMA" id="WETIVEF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3048" evidence="1">
        <location>
            <begin position="79"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="2">
        <location>
            <begin position="251"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="396" mass="44761" checksum="D0D91370071F2D96" modified="2011-04-05" version="1">MKKFGLLWGIFFLVILGISACETTPPQPVVWSAAEPEKALAQDIPETLPTPRLEQRPIPTPTPMPLSELPEHPDNINPLTGLPVSDVSRLERRPVMVKISNYPRAGRPHMGLSHADLVFEYYIGLGFNRFLAVFLGDDAALAGPVRSGRLVDAQLAEMYQGILFYGNADDRTDEVLVQELGPRALAERDIPSPPKYRIEAEIPETTLFVNTRELSEYYTNSGRGSNERRDLRGMIFSDQIHPVNEKADFLAVQFSRQARGEWRYNPETGLYERWIEAGSSEETIPMIRLVDRENNKQIAFANVILLFATYTEYAPTLHDIALFDQNSGKRAIFFRDGVRIEGTWVTASNGRPIQFFNSYGLPMHLKPGNSWIVLVGETSIFRNLAPGQWELRFDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N494</accession>
    <name>E8N494_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_12240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559646.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63258">
        <property type="protein sequence ID" value="BAJ63258"/>
        <property type="gene ID" value="ANT_12240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12240"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102055_1_1_0"/>
    <dbReference type="OMA" id="EWDNDEL"/>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="13"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="25296" checksum="5A104072AF6319C2" modified="2011-04-05" version="1">MPREYSADELLPLSGIQHFLFCRRQWALIHVEMQWKENVLTAEGRLMHQRVDDPFFTEVRNGVILARSVPIASYRLGLSGICDAVEFTSSPEGVKIPGREGKYLPIPVEYKRGRPKSDPVDEVQLCAQAMCLEEMLSVSIPAGYLYYGETRHRTAVNLGNELRELVQKMAGEMHAYFERGYTPKVKPSKACRSCSLIDICLPNVQEKATSVANYIREWVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E1</accession>
    <name>E8N4E1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobalt ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiO</name>
        <name evidence="5" type="ordered locus">ANT_12710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63305">
        <property type="protein sequence ID" value="BAJ63305"/>
        <property type="gene ID" value="ANT_12710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12710"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="YALELCP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="236" mass="25911" checksum="3A6AB20A413C3D61" modified="2011-04-05" version="1">MSCVIEVKNLSYAYPDGHQALHDVSFRISHGEKVALIGPNGAGKSTLILHLNGILPVQQGEIFVGDLAVVPKNFSRVRALVGLVFQTPDDQLFSPTVFDDVAFGPIYQGLSPAQVQERVDYALSMVHMREYAPRVSHHLSVGEKKRIAIATVLSMNPIALVLDEPTAGLDPRARRSLIELLRQLPQSMLVATHDLPMVRELFPRTIVMDQGRIVADGSTDVLLHDESLLNEHGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J9</accession>
    <name>E8N4J9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CpXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559750.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63363">
        <property type="protein sequence ID" value="BAJ63363"/>
        <property type="gene ID" value="ANT_13310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13310"/>
    <dbReference type="eggNOG" id="ENOG5032TQR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628281_0_0_0"/>
    <dbReference type="OMA" id="QNPAMIT"/>
    <dbReference type="OrthoDB" id="856513at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025682">
        <property type="entry name" value="CpXC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14353">
        <property type="entry name" value="CpXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CpXC" evidence="2">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="449" mass="51265" checksum="75EECD2273E36192" modified="2011-04-05" version="1">MAKIQTSCPRCRQPVLAEVEQLLDMKVDPKAKQKLLAGTYNRAVCQNCGYDGPIPMPLVYHDPEKELLLTYFPPELGIPLNEQERLLGPYIKQVTERLQPEERKAYLFRPQSMLTMQTMIDRVLEADGITREMIEKSQKRLNLIQRLLNATPSSRPEIVRQEEEIIDQEFFQMLGQLIEASLAGGDRATAQALVNLQKEILPLTQVGQQILSDSSAIQTALQDLQEAGKRGLTREALLDLMLKQTNPAAVEALARVTVTGLDYEFFTILSERIEKAPEAEQSRLVQLRDKLLAMTQEVNRQIQEQMQSARKLVDNILNAPNLEKALEENLGSLDEFFAEALREALEQARQKGDIERSARIQKIVSILQEAAKPPAEYELIENLLSLQDEVSRRELLEKNEEKITPEFLQILSGLVSQMEEQGQEEFAHQLERVYKQVLRFSMEMNMKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N4</accession>
    <name>E8N4N4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_13700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559782.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63398">
        <property type="protein sequence ID" value="BAJ63398"/>
        <property type="gene ID" value="ANT_13700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13700"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="SHCVWSD"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="347" mass="38309" checksum="49B89CF466318B34" modified="2011-04-05" version="1">MRSRKQVTIRDVAREAGVSAQTVSRVLNQHPDVSDETRKRVQDTIERLGYSPNYVARSLIQGRTHTIGVVGYGLGYYGPSRALTGVEKQANELGYSILLSLVRQAEINSGRQLIANLLMRKVDGIVWAVPEIGPHREELLEDLAQIDVPVVFINMNPRPGCQVAAVDNFNGGRLATLHLLSRGCQKIGIITGPEAWWESQQREAGWKTACLESGRVKESEISALKVVGDWEAASGEAGFMTLIQKVPDLDGVFVCNDQMALGALKAARQLGIRVPEDIALVGFDDIPEAAFFNPPLTTLRQPLTELGAQAVRMLHHRLCNEEHDVHASEIIWLQPELIVRESSRKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N7</accession>
    <name>E8N4N7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein ANT_13730</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_13730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559785.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63401">
        <property type="protein sequence ID" value="BAJ63401"/>
        <property type="gene ID" value="ANT_13730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13730"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_0"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="252" mass="28239" checksum="FD6CE849729796A8" modified="2011-04-05" version="1">MSGHSKWATIKRKKGAMDAKRGQLFTRLTREIVMAAREGGGDPETNFRLRLAVEKARSQNMPKENIERAIKRGTGESKEGNAFEQVFYEGYAPHGVALMIECYTENRNRTVAEIRHLLSRAGGNLGEAGSVSWQFKRMAYFALSASKVDFDRVFEVAVENGAEDVTQDGDTIEVFAPVENFKVLSDAFRNAKMELEEAELRMIPTNEVELGVEETLQVLRTIDTIEELDDVQNVYHTMKISEAALAALENEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4P1</accession>
    <name>E8N4P1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="9">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">atpA</name>
        <name evidence="13" type="ordered locus">ANT_13770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559789.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63405">
        <property type="protein sequence ID" value="BAJ63405"/>
        <property type="gene ID" value="ANT_13770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13770"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_0"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="12">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="10">
        <location>
            <begin position="149"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="10">
        <location>
            <begin position="359"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="11">
        <location>
            <begin position="423"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="9">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="555" mass="60475" checksum="3769BF5C8EDCD5AE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R2</accession>
    <name>E8N4R2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">parA</name>
        <name evidence="2" type="ordered locus">ANT_13980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559808.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63426">
        <property type="protein sequence ID" value="BAJ63426"/>
        <property type="gene ID" value="ANT_13980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13980"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_0"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="262" mass="28558" checksum="81A5583AD660E1C0" modified="2011-04-05" version="1">MARVYTLVNQKGGVGKTTSAINLGAYLGYYGQRVLLIDLDPQANATSSLGVDKNSIRGGTYEVLIGRMPITPQILHNPRYKISLLPSSPALAGAEVELVDLPNREQRLKEVLAPALERYDYILIDCPPSLGLLTVNGLVAAANGVLIPVQCEYLALEGLGQLTQTIQRVRNSLFPELQIRGVILTMFDGRTRLATDVVAEVRKYFPDKVFQTIIPRSIRLAEAPSFGKPISVYAPESHAAQAYQALAKELLALDGIHIPELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T5</accession>
    <name>E8N4T5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14210"/>
    <dbReference type="EnsemblBacteria" id="BAJ63449">
        <property type="protein sequence ID" value="BAJ63449"/>
        <property type="gene ID" value="ANT_14210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14210"/>
    <dbReference type="HOGENOM" id="CLU_2327764_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="98" mass="10639" checksum="3C3320CE2EE2F651" modified="2011-04-05" version="1">MQTCSRCKTVVSDEVVVCPTCQADLRKESTTAIALRQMQENPRVYAIHVAVSADACPACMAVEGTYLKDQVPTLPVEGCSNPNGCKCTYQPLLTEIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W0</accession>
    <name>E8N4W0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63474">
        <property type="protein sequence ID" value="BAJ63474"/>
        <property type="gene ID" value="ANT_14460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14460"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084360_0_0_0"/>
    <dbReference type="OMA" id="YFALREH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="256" mass="28587" checksum="E91AFF6DD3050CDF" modified="2011-04-05" version="1">MSMIIEYHRPETLEDALALLSRTFPRTLPLAGGSYLSRHANEDIAVVDLQKLGMDFVEVTDRGLSIGATTRLQSLVDHPDLPQWLRQSAHRETSANLRRMQSLAGTLVTSSGRSVLGTSLLAADARLQWLPGEEEKSLGDYFALREHWNQGILIRSIFVHTKVKVAVDWVARTPRDLPILVVAVARWQSRRTRIAVGGFGKTPLLVLDGPEPGGAEVALRSVLKQSDDEWASSEYRMDVGEKLLRRLLKLLETMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W4</accession>
    <name>E8N4W4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559860.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63478">
        <property type="protein sequence ID" value="BAJ63478"/>
        <property type="gene ID" value="ANT_14500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14500"/>
    <dbReference type="HOGENOM" id="CLU_1933643_0_0_0"/>
    <dbReference type="OrthoDB" id="2181279at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="130" mass="15332" checksum="AEC3B41375B45EC0" modified="2011-04-05" version="1">MPKYGSYQSERDREEREQRRQIHPIWRGVGFAFLVLIPLLSYAAAEVFISWNTKSNQFPWPYDLMARPGNFLYNGDPWLYYKAILTLAFMLVLYALFTFVTFLLNSAFAPPRYGPYDVPPIKGRVRKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N581</accession>
    <name>E8N581_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_15670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63595">
        <property type="protein sequence ID" value="BAJ63595"/>
        <property type="gene ID" value="ANT_15670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15670"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_524456_0_0_0"/>
    <dbReference type="OMA" id="CQRIVKN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="271"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="519" mass="58389" checksum="8356DFCB1FC6FDE6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N589</accession>
    <name>E8N589_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hemN</name>
        <name evidence="11" type="ordered locus">ANT_15750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15750"/>
    <dbReference type="EnsemblBacteria" id="BAJ63603">
        <property type="protein sequence ID" value="BAJ63603"/>
        <property type="gene ID" value="ANT_15750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15750"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_1_1_0"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="10"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="405" mass="46297" checksum="96B2EE6E68AF27C9" modified="2011-04-05" version="1">MQVNQRYDILPTMIPVSIYIHIPFCVHRCAYCDFNTYAGMEKWIPAYTEALCREIAVVSEAAPEGISVQTIFFGGGTPSYLSASLLNKVLHTVRSHFQVMEKAEISLEANPGTVEPHLFEELREAGFNRLSIGMQSAIPKELKFLTRIHTVEDVQNSVIQARKAGFQNINLDLIFGIPGQTIQTWKNSLEFALSLQPEHVSLYSLTVEEGTPLNHWVEEGKISMPSDDDAAELYEYSMDAMAEAGYLQYEISNWAKQDLNGDWLMCRHNLQYWRYLPYLGFGAGSHGFFENTRISNVLGIPEYINRIKSLSSHQFPASAAVDQILILDRQEQMKEFMMVGLRLTHEGVSLLEFYHRFGVSLLEVFGKEIEFLLARGLIEWFNENKRLRLTKRGKLLGNQVFLYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A7</accession>
    <name>E8N5A7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_15950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15950"/>
    <dbReference type="EnsemblBacteria" id="BAJ63621">
        <property type="protein sequence ID" value="BAJ63621"/>
        <property type="gene ID" value="ANT_15950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15950"/>
    <dbReference type="eggNOG" id="COG1608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070213_0_0_0"/>
    <dbReference type="OMA" id="HHNASEH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04241">
        <property type="entry name" value="AAK_FomA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="270" mass="29899" checksum="9372A1E4EF7BD750" modified="2011-04-05" version="1">MSMDSNLTFLKLGGSLITEKDKPRTPRAKIIQQIAWEIREALREIPNLRLIIGHGSGSFGHATAKKYRTREGVYTLEDWYGFVHVWYDARALNQLVIDALFSAGLPVIAFPPSAITFREGKKVQIATQLIQIAIEKGLIPVVQGDVIFDLDQGGTILSTEEVFAELSFHLRPQRILLAGVEEGVWADFPLRHSLVTEISEDTIKSENIQISGSIATDVTGGMAEKVKSMLDLCQRVPGLEVWIFNGLKKGNVLNALRGFPMGTKILSRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H7</accession>
    <name>E8N5H7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">prfB</name>
        <name evidence="7" type="ordered locus">ANT_16650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63691">
        <property type="protein sequence ID" value="BAJ63691"/>
        <property type="gene ID" value="ANT_16650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16650"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_6_0_0"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="6">
        <location>
            <begin position="64"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="40051" checksum="7FEA97AA77E80A2B" modified="2011-04-05" version="1">MNSRSIFDLSSREMLLEQLQKEAENPGIWDDPTSAQRLMKRIADLREEIEGWNQFLKRCQDGLELAESEDESLREDLEKEISALEKELQQRELTTLLSGPYDHENALLTINAGAGGTDSQDWASMLMRMYLRWCERRGFDSEILDFSEGEEAGIKSVTIAVTGPYAYGYLRGEKGVHRLVRLSPFDAAHRRHTSFAQVEVLPEISNGDNEIQINPDDLRIDIYRSSSAGGQNVQKNATAVRITHIPTGIVVSCQNERSQMQNRENAMRVLRARLAELKRQEQERQLAELRGEYIKAEWGSQIRSYVLHPYQLVKDHRTEYETGNTQAVLDGELDGFIEAYLRSQKTKSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K7</accession>
    <name>E8N5K7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16950"/>
    <dbReference type="EnsemblBacteria" id="BAJ63721">
        <property type="protein sequence ID" value="BAJ63721"/>
        <property type="gene ID" value="ANT_16950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16950"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_5_0"/>
    <dbReference type="OMA" id="YPHMPTG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="39"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="397" mass="44094" checksum="BAE36F88C99E36E0" modified="2011-04-05" version="1">MTGLKPMMFQPADRIASFKPYFFAQLNQKINELRTKNVDVIRLDMGSPDLPPASFIIEALVASARQDDTHGYTQMGGSLAFKKAVAHYYQTRFGVNLDPQTEVLALIGSKEGLFNLAQVILNPGDVSLVPDPAYPVYASASIIAGAEVHYLPLLQENQFLPDLERVPEDVLAKAKLIWINYPNNPTGAIASLKFYEKLVEFAFKYHILIANDAPYMDICFNGYQAPSILQIPEAKQVAVEFNSLSKTYNMAGWRVGMAVGNAQVIKYLHTYKSQADSAHFQPVIDGAIAALTGDQSWLEERNAIYLQRRDLIISTLQGLGFEVTPPPAAIYVWAKLPSPYKDSVEFCNQLLEETGVSTTPGVVYGKYGEGYLRISLGTPTDRIAEAMKRLQDWLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L0</accession>
    <name>E8N5L0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmF</name>
        <name evidence="6" type="ordered locus">ANT_16980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63724">
        <property type="protein sequence ID" value="BAJ63724"/>
        <property type="gene ID" value="ANT_16980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16980"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_3_0"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="62" mass="7037" checksum="EE519355C1338F89" modified="2011-04-05" version="1">MVPHPKRKHSQGRRDRRRSQDTLKATNLVACSNCGELRLPHTVCPNCGHYKGVEVVARESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W2</accession>
    <name>E8N5W2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63826">
        <property type="protein sequence ID" value="BAJ63826"/>
        <property type="gene ID" value="ANT_18000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18000"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091701_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="116" mass="13265" checksum="8714673195A54E1C" modified="2011-04-05" version="1">MTETQNQNRPEWGIDSTHPELVEPLTEALRTIVDPEIGLNIIQLGLVRDVTIEDGNALIKMILTTPFCPYGPAMLETTRQKTEEVLGIPTHIDFRADEMWDFSYMEEGLIDDWGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N675</accession>
    <name>E8N675_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19130"/>
    <dbReference type="EnsemblBacteria" id="BAJ63939">
        <property type="protein sequence ID" value="BAJ63939"/>
        <property type="gene ID" value="ANT_19130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19130"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602238_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="454" mass="52863" checksum="D2308A6A9CB452E2" modified="2011-04-05" version="1">MSGHKRTTVTISQEEYRRLYEAEMLLRGMDTKPFETNHQPSPETLAFLSQQVNSTIQRQENFLRLGQELQTEFSHLETQTAFYLREIQGQILEMLNQDRENFINLVDQIQNNLNYIEEKTIREHEATQQRLAELEFQSQQTFQREKYTSELAHEWLNDCVQIYNFILENYPESIPHLEELRDISSQLGIALQNFESGLYEAALTTGQNLYIFLSSLRVQLEKEGLEKRKILAEILEELRAIKKEIVENREIKPLDLQGNFLDTLISVDEWTDNSLSNLEETISSIIIQFEEQGLEHPIEYLRNFKANQIPLIQNEFLEAIHQARLSALNAHLNYLIAHDVLLALIEQGYKPVEGHYKPGEKDIYIAKAEDPLGNVVEIQVQTSSPEKIEHHLHIISTYNQTQSLHELRQRAREIQRSLKRIGWVAHESIEIPSSAQRITQQPQKVSLNSNGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N680</accession>
    <name>E8N680_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560320.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63944">
        <property type="protein sequence ID" value="BAJ63944"/>
        <property type="gene ID" value="ANT_19180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19180"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_4_0"/>
    <dbReference type="OMA" id="FLEQRQF"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="74"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="334" mass="37442" checksum="C8AD33A82B549108" modified="2011-04-05" version="1">MVLRNQKPRDAGKGLSFAGWAAIAAGGWILYSHFGINHRVPLPEAIPANRESFFTKLAGRVNYYFDLSGTGRPVVLIHSINAAASAYEVSPLFLYFRGQRPVYAIDLPGFGFSERSDRIYTPQLYEDTIVDFLSSQVKQPVDVIALSLSGEFVSRAALSYPEWFNSLTLISPTGLGKNLLPGMDFAFGGFPIGHFAHALLTLPLWARPLFDLLATRTSIEFFLKKSFVGHVPSGFIEYAYASAHQPGAEHAPLYFITGKLFTPQVRTQVYERLKTPVLVLYDRDLYTSFERLPDVLLKNPFWQAVRMVPSKGLPHFERLADTVEVIEGFWRGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXE2</accession>
    <name>E8MXE2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 19" type="primary">uvrB</name>
        <name evidence="19" type="ordered locus">ANT_19970</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19970"/>
    <dbReference type="EnsemblBacteria" id="BAJ64023">
        <property type="protein sequence ID" value="BAJ64023"/>
        <property type="gene ID" value="ANT_19970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19970"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_0"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="UVR_dom"/>
    </dbReference>
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        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="UvrB"/>
    </dbReference>
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        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="428"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAJ64023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="680" mass="78110" checksum="A8B8A493024D7D00" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL6</accession>
    <name>E8MXL6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ64097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64097">
        <property type="protein sequence ID" value="BAJ64097"/>
        <property type="gene ID" value="ANT_20710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20710"/>
    <dbReference type="eggNOG" id="COG4478">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314005_0_0_0"/>
    <dbReference type="OMA" id="VFDPYSW"/>
    <dbReference type="OrthoDB" id="1194255at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010178">
        <property type="entry name" value="Integral_membrane_1906"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="integ_TIGR01906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="26118" checksum="3F54C947666E3C23" modified="2011-04-05" version="1">MKFWKNAGVLLIAVSVPFFLMMTAIRLLLTPLYPEIEYRMPYFPPDPYGFTLEERLKWSKISIEYLLNDSDLSFLANQKLDPQTPLYNERELKHMLDVKILVQQMITVWSILAGVYVILLAWAWRRGWMTDLLRAFSWGGKGAIALILLILVSVVLNFNALFTAFHQIFFEGNSWLFRYSDSLIRLFPLPFWRDAFIWVGAFTFLASLILIWIEKHTRNISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS6</accession>
    <name>E8MXS6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21310</name>
        <name evidence="2" type="ordered locus">ANT_23960</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="1">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64157">
        <property type="protein sequence ID" value="BAJ64157"/>
        <property type="gene ID" value="ANT_21310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64422">
        <property type="protein sequence ID" value="BAJ64422"/>
        <property type="gene ID" value="ANT_23960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21310"/>
    <dbReference type="KEGG" id="atm:ANT_23960"/>
    <dbReference type="HOGENOM" id="CLU_3179507_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="46" mass="5057" checksum="079C8A594DBF6790" modified="2011-04-05" version="1">MTRSLAGAMWAMLIRVALTAMVGRLLTEALAGYYAGLTRTLLRLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT1</accession>
    <name>E8MXT1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21360</name>
        <name evidence="2" type="ordered locus">ANT_24010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="1">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560532.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21360"/>
    <dbReference type="EnsemblBacteria" id="BAJ64162">
        <property type="protein sequence ID" value="BAJ64162"/>
        <property type="gene ID" value="ANT_21360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64427">
        <property type="protein sequence ID" value="BAJ64427"/>
        <property type="gene ID" value="ANT_24010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21360"/>
    <dbReference type="KEGG" id="atm:ANT_24010"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116293_0_1_0"/>
    <dbReference type="OMA" id="DIAPGFW"/>
    <dbReference type="OrthoDB" id="1792346at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016541">
        <property type="entry name" value="UCP008505"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14367">
        <property type="entry name" value="DUF4411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="169" mass="19929" checksum="D1A21C36420FA736" modified="2011-04-05" version="1">MKYCLDANVFIEPSKGWYAFDIAPAFWDALLEWRQKQILCSILPIYDEIVEHKEQNALVRWVKEHGKDFFLPLDEDAWIEFGNIADLVRRRYEDHIAEDFLDCSDPMVIAYARAHGLIVVTEEKWKNEDQKSNGKVGGKKIHIPNVCQLVEVQWISTVEMLRDLKFQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU7</accession>
    <name>E8MXU7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560548.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21520"/>
    <dbReference type="EnsemblBacteria" id="BAJ64178">
        <property type="protein sequence ID" value="BAJ64178"/>
        <property type="gene ID" value="ANT_21520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21520"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276179_0_0_0"/>
    <dbReference type="OrthoDB" id="600220at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1153" mass="123749" checksum="57F220D2AF03CFC4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX5</accession>
    <name>E8MXX5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FtsK/SpoIIIE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560576.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21800"/>
    <dbReference type="EnsemblBacteria" id="BAJ64206">
        <property type="protein sequence ID" value="BAJ64206"/>
        <property type="gene ID" value="ANT_21800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21800"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620608_0_0_0"/>
    <dbReference type="OrthoDB" id="175945at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="119"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="441" mass="48631" checksum="FAAEBA0A74D223E0" modified="2011-04-05" version="1">MITHREQRVAETLAYRLPGVLTRRGLKAPIRQFLLSEVNGLKMLIAEVDLGGVNYPERYTTPEVLSHLRLEMGVPVYLSQVKGLRYVLLLSPLPQMPRRVELPPDVPSGQFAVGVGVSGRGLSLAWEDLQHLAVLGATGSGKSVFLQSLVWQGLRDGLRLLLSDIEGVTFGMLADHPGLLAPVAETPAGALERVEQALAECERRAKLLREAPGHPQNLKQYNERIQTEGGEALPRILVILDEASAVLSAMGRGRGELGEALANLGWRGRKYGVHFVFAAQEFTKELLGPVRDQVGMAVCFRVRSAYLATHMGCRGAERIPVDRPGLAITDRWGPVQTYYLDAGRLEQGKEGLQVPVSEAERGWFLQALKAGGRLSRSNLMAWSGMSEWQARKNLEAWAMRGWVVKEPQEDNAFVVTEKMREWLSNPPTSPACSNHSNLIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY58</accession>
    <name>E8MY58_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_22630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64289">
        <property type="protein sequence ID" value="BAJ64289"/>
        <property type="gene ID" value="ANT_22630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22630"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_0_0_0"/>
    <dbReference type="OMA" id="NRGPLFY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="280"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="468" mass="53368" checksum="198BB9C6F7B6C777" modified="2011-04-05" version="1">MEREYSRWRLRPEERRTILVIGDFIVALLALVIALVAWGQRDWLDFSQLLMQRIPRWFFLLPLGWLLLNIEMYDIRRAGRKDETVKGILIAAGVGLMLYLFVFFFSTPGDMPRVGVAVYIAAVTLLTLGWRFLYIRVFTAPEFLRRVLIVGAGVAGTTLANVVNSIRPQPFQIIGFIDDDPEKVGTEIAGLPVIGDSSRLLELIEKYQITDLIFAISGDLRPETFRVLVDAQERGVQITTMISAYERLLGRVPIFLLPTEWILRSFVDYAHTDSFYEMSKRILDILGGLVGTLITLVLYPFIALAIWLDSGSPVVFTQTRVGKNGKEYTIYKFRTMRQDAEKDGKARVTVENDERITRVGKILRKSHLDELPQFINVLRGEMSLVGPRAERLELVQSLQKKVPFYRARLLVKPGITGWAQVNFGYAATVEDTAIKLEYDLYYIMHRNLLLDLLILLRTVGTVVGFKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY80</accession>
    <name>E8MY80_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="8">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ileS</name>
        <name evidence="11" type="ordered locus">ANT_22850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560678.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22850"/>
    <dbReference type="EnsemblBacteria" id="BAJ64311">
        <property type="protein sequence ID" value="BAJ64311"/>
        <property type="gene ID" value="ANT_22850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22850"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_0"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="682"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="597"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1051" mass="119732" checksum="815405104C78225F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY89</accession>
    <name>E8MY89_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmH</name>
        <name evidence="6" type="ordered locus">ANT_22940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560687.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22940"/>
    <dbReference type="EnsemblBacteria" id="BAJ64320">
        <property type="protein sequence ID" value="BAJ64320"/>
        <property type="gene ID" value="ANT_22940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22940"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_1_0"/>
    <dbReference type="OMA" id="RMASVNG"/>
    <dbReference type="OrthoDB" id="2069770at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="57" mass="7047" checksum="6A93E814FA44E9D4" modified="2011-04-05" version="1">MSTKRTYQPKIHRRLRVHGFRARMATADGRQVLKRRRLKGRYRLTVSMNNHTKRIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC9</accession>
    <name>E8MYC9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558472.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00400"/>
    <dbReference type="EnsemblBacteria" id="BAJ62074">
        <property type="protein sequence ID" value="BAJ62074"/>
        <property type="gene ID" value="ANT_00400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00400"/>
    <dbReference type="eggNOG" id="ENOG502Z8JB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721150_0_0_0"/>
    <dbReference type="OMA" id="IPYEGVR"/>
    <dbReference type="OrthoDB" id="1936526at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="37670" checksum="9E531C68804C5B6B" modified="2011-04-05" version="1">MLAQVTHILGLTSIRRVRTLPVSGRVLVASRQKVNASDVIAEAQIPAQHVLVDVRRALRLGSVEQAQRVIVRNEGERIFAGDVIAETGGLFPRMVRAPADGQVVMIAGGRVIIEVQSQPIQIFAGVPGYVVEVIQERGAVIEGQGALIQGAWGNDRVAEGMMINLLNSPDEELTRQKMDVSLRGAVVVGGMCSDPEVLRMGEELPLRGLILSSMSASLVPVARSVSYPVMLTEGFGRIPMNEAAYTLISTNDKRDVALSTPFRPQAGERPELIIPLPAVGEPAADFAYFKPDQKVRILGAPYPSHVGVLVRLLPGLTTLPNGVRAQAAEVRLSKDTLVVVPLANLEVIQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE6</accession>
    <name>E8MYE6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00570"/>
    <dbReference type="EnsemblBacteria" id="BAJ62091">
        <property type="protein sequence ID" value="BAJ62091"/>
        <property type="gene ID" value="ANT_00570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00570"/>
    <dbReference type="HOGENOM" id="CLU_3094961_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="51" mass="5597" checksum="FC6602A0650DC79E" modified="2011-04-05" version="1">MLQLYPADGKNLFALAQNMGEKHGSPRQEPSRTASLPASRFVLKESPSKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK0</accession>
    <name>E8MYK0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UvrABC system protein A</fullName>
            <shortName evidence="14">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">uvrA</name>
        <name evidence="17" type="ordered locus">ANT_23100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560703.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23100"/>
    <dbReference type="EnsemblBacteria" id="BAJ64336">
        <property type="protein sequence ID" value="BAJ64336"/>
        <property type="gene ID" value="ANT_23100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23100"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_1_0"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="623"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="757"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="658"/>
            <end position="665"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAJ64336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="968" mass="107263" checksum="5D1B7559986EBF19" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYL0</accession>
    <name>E8MYL0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ordered locus">ANT_23200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560713.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64346">
        <property type="protein sequence ID" value="BAJ64346"/>
        <property type="gene ID" value="ANT_23200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23200"/>
    <dbReference type="eggNOG" id="COG1540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069535_0_0_0"/>
    <dbReference type="OMA" id="DRTYKQD"/>
    <dbReference type="OrthoDB" id="918580at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="251" mass="26417" checksum="4D23EB69B673A304" modified="2011-04-05" version="1">MDLNCDLGESFGNYRLGNDEALLSIVTSANIACGLHAGDPLVMGRTVRWAVSKGVAIGAHPGYPDLQGFGRREMNMSAEEVEAFVLYQIGALAGFVRAEGGELVHVKPHGALYNQAAKDRALARAIVQAVKRFSPHLIVVGLAGSVLVEEAREAGLPAAAEGFPDRAYNPDGTLKSRREPGAVLQTVEAVCQQAIRLATQGAGEGTQRVPVDTLCIHGDGAHAVEFATAVRESLLTAGVALRSLSPESLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP0</accession>
    <name>E8MYP0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560742.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64376">
        <property type="protein sequence ID" value="BAJ64376"/>
        <property type="gene ID" value="ANT_23500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23500"/>
    <dbReference type="eggNOG" id="COG2768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046240_0_0_0"/>
    <dbReference type="OMA" id="PECDCMP"/>
    <dbReference type="OrthoDB" id="1000643at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="387" mass="42971" checksum="DB5AA0AC5CC68DD9" modified="2011-04-05" version="1">MASKVYWGSPRQAKLEARETLPAKLDLIIDALHLRDRVKKELVVIKMHTGNNIGYSTVHPVFIRKVVQAVKDGGGEPIVADVEWDVHAAHSRGYTSETLGCPIYPVSGPADKYYYTHRRPYKSIEEWRLGGLIQDATFLINFAHAKGHPSCGYGGAFKNLALGCMSGKTRSAMHDVMHYDQYWFPEACPDEASRKAIIESCPFGAIVQDRDNPEGLHLHFEGCNQCGRCLKVAPPGSLKIDPVNFHSFQEAMAISTSITLSTFEPGKAVHFVLATHMTPVCDCFGFTSMPILPDAGIFGSDDIVALDQAVLDMTAKTPLIEENVPTSMEVHTREGHPLRWLHGPYKDPYKVVEYGEKLGLGSREYELIDVLPVQQFQRTSVTYIPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ2</accession>
    <name>E8MYQ2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560754.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64388">
        <property type="protein sequence ID" value="BAJ64388"/>
        <property type="gene ID" value="ANT_23620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23620"/>
    <dbReference type="eggNOG" id="COG2839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109297_3_1_0"/>
    <dbReference type="OMA" id="KWGQIGA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007403">
        <property type="entry name" value="DUF456"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04306">
        <property type="entry name" value="DUF456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="167" mass="18015" checksum="E87434BF6EC3D6DA" modified="2011-04-05" version="1">MEFTELLRYSFYAIILSVMLFGLLGLIIPILPGLVIIWVAALVFGIVEGFSSAGWVFFAAMTVLMLVGSVIDNFIMGASARQKGAPWTTILVALVLGIVGSVLLPPFGGVIAALLGLFGLEYYRQRDWRKALDTTTGMAVGCGGAVLIRAGMGVIMIILWLIWALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ3</accession>
    <name>E8MYQ3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64389">
        <property type="protein sequence ID" value="BAJ64389"/>
        <property type="gene ID" value="ANT_23630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23630"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072983_1_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="187" mass="21650" checksum="DF95388E670331FF" modified="2011-04-05" version="1">MSNAESQIRAAIEHGLDAIAFTDHFRLVPSGELAAFNEQFAPFRVYSGIEITADKEDWLVFGVQDPRIERRLWTYPDLWHFVRDRGGVIILAHPFRWEPLIHVDLEKYPPDGVEFRSHNTPVERQEDIIRLACQYGLGLFQNSDSHHVRMMGQYYNELPGYPDGETALLESLRALKTLTPCAEKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYR7</accession>
    <name>E8MYR7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23770"/>
    <dbReference type="EnsemblBacteria" id="BAJ64403">
        <property type="protein sequence ID" value="BAJ64403"/>
        <property type="gene ID" value="ANT_23770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23770"/>
    <dbReference type="eggNOG" id="COG4990">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843702_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="163"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="36250" checksum="C8D29EAB44859A9D" modified="2011-04-05" version="1">MGSILTNKYGNVNEKFLTQWVKSSTMKRSTYYPLSSNDMPKPARIHLVLSLFVFLLLSTCTGVEFTTRKPATELSANINQSLGVQQVERSGVGFALMGKISPFTPTPIPTSTPTPFQPVPPTATPIPPTPTPTATATEPSPPSFPEEHFIRNISGHPQYFSLSCEAAVATDWAAYFGVTISEYNFQFELPRSDNPEKGFVGDVNAPWGQIPPYGYGVHAQPVANLLNQYGLPARAVKGWSVEEIKAELANDQPVIVWVIGNVEGGIPYEYTDKEGNMVIVAAYEHVILVTGYSKTHLRYISNGAFYDVPIEVFENSWKVLGNMAIYYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS2</accession>
    <name>E8MYS2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ResIII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23820"/>
    <dbReference type="REBASE" id="32153">
        <property type="entry name" value="AthUNI1ORF23810P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64408">
        <property type="protein sequence ID" value="BAJ64408"/>
        <property type="gene ID" value="ANT_23820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23820"/>
    <dbReference type="eggNOG" id="COG4096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008858_0_0_0"/>
    <dbReference type="OMA" id="NQEIAFK"/>
    <dbReference type="OrthoDB" id="13585at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ResIII" evidence="2">
        <location>
            <begin position="157"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1073" mass="123539" checksum="4A5A3C9F274C7FBD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYU6</accession>
    <name>E8MYU6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64432">
        <property type="protein sequence ID" value="BAJ64432"/>
        <property type="gene ID" value="ANT_24060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24060"/>
    <dbReference type="HOGENOM" id="CLU_3323759_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="38" mass="4165" checksum="9D0717F7B1AD339F" modified="2011-04-05" version="1">MGRRVLFLVALFSLLVAGVSPIRAQSLPTVEVWVSVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW1</accession>
    <name>E8MYW1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_24210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64447">
        <property type="protein sequence ID" value="BAJ64447"/>
        <property type="gene ID" value="ANT_24210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24210"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411994_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228489" evidence="2">
        <location>
            <begin position="19"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="666" mass="73665" checksum="18A3289359090122" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ18</accession>
    <name>E8MZ18_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558559.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01270"/>
    <dbReference type="ESTHER" id="anatu-e8mz18">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62161">
        <property type="protein sequence ID" value="BAJ62161"/>
        <property type="gene ID" value="ANT_01270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01270"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_13_1_0"/>
    <dbReference type="OMA" id="DVPHVFQ"/>
    <dbReference type="OrthoDB" id="1587940at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="5">
        <location>
            <begin position="72"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="35660" checksum="6EBB53EA9321B712" modified="2011-04-05" version="1">MSFVSQLFLGVLRLFPFVPHSNWSIHQQRDVLEFYARLLLHTPPGVRIGFAAAGGPRAEWLIPERNTPDQVILYLHGGAYTVGSPRTHREMVGYLSLFARTRALVVDYRLAPEHPFPAALEDALAAYHHLQRLGYPPHKIAFAGDSAGGGLAMATLLALRDRGEPLPAAAALMSPWTDLAGVGESVKTHETRDPLINPADLPVAARLYLRDLDPRHPYASPLYGDFHGLPPILVHVGTEEILYTDSTRLVERLLEDGVDAKLVVWEGMWHVFQLFTLRVPESWRSLRQMGSFLHHHLSRAQAEETNPQSIQKEKVPVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ58</accession>
    <name>E8MZ58_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558599.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01670"/>
    <dbReference type="EnsemblBacteria" id="BAJ62201">
        <property type="protein sequence ID" value="BAJ62201"/>
        <property type="gene ID" value="ANT_01670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01670"/>
    <dbReference type="HOGENOM" id="CLU_965227_0_0_0"/>
    <dbReference type="OrthoDB" id="2134153at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="288" mass="31138" checksum="680F3FDC2CF6397D" modified="2011-04-05" version="1">MGLLLTRGGVLAPLSVLASLDPLRGSFTAVCPSQKGFPSLIGRMVYTPGERSAHLAFLLPVSGVEHPGLPALMESLAATAGAWGALNLLAEVEETQPALEAFRRSGFAVYGWQSIWKFDSPPASRRSGEWRPPLPTEENAVRSLYQLLVPPLVQAAEPFAGHTGERLVYRQGGEILAYADLLYGPEGVFIQPLLHPGLKQPEEALQALLGCFISLPARPVYVAARSYQAWLEPVLNRLGGYVSPRQALLVRHLVATARVGVLARQIAGESFNHEATVPMIQSSTIYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ88</accession>
    <name>E8MZ88_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558629.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01970"/>
    <dbReference type="EnsemblBacteria" id="BAJ62231">
        <property type="protein sequence ID" value="BAJ62231"/>
        <property type="gene ID" value="ANT_01970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01970"/>
    <dbReference type="HOGENOM" id="CLU_1736750_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="16140" checksum="66F1F35DDCD7DDE5" modified="2011-04-05" version="1">MRLSGWDVLSIVLLAGMAFLILIFSIIFINPYVMINPYPPPTPVPTLFVPSPTATLRALPTIARTSPFEVPTATPRPLRPTSTLPPTATGFRLPTFTPTPTRTSTPTNTRTPTNTPTFTVPPTYTSTPVTPSPTPVTPTEPVSTIYPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZB0</accession>
    <name>E8MZB0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558651.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02190"/>
    <dbReference type="EnsemblBacteria" id="BAJ62253">
        <property type="protein sequence ID" value="BAJ62253"/>
        <property type="gene ID" value="ANT_02190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02190"/>
    <dbReference type="eggNOG" id="ENOG502ZKEG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_770801_0_0_0"/>
    <dbReference type="OrthoDB" id="550203at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="41370" checksum="9767E62BFE54DE56" modified="2011-04-05" version="1">MREALLDEVRDGFLLAFRRWPVMFMLAGMITLATVVLSFALSDVLSEGYVLRGARALREHHAVFFTAYYPEGGEVSRIEDATVKSLMNWIDQQRAYTSIVYNMALDDPDFAGGYPTLILFGDVVPNLFPEMHLCVPVPCAVRGAKVRGDAVDSINVGGIEILVKQIFPRGAAFFDVNAAGLPLDHRIVIRAPTEVIPVLHPIEQEELITRTVLLDPTDSMVYEFISGAARGGLFLVPHEVSMEQPKQFREIMMRSAMYLVGMVAFLVLALMTFVSSARLAIQQERREFKIRQMYGATPWHISLRIGGFLAAVILLPETALLFLLQRFLVIAGALEPNAPIWVMILLVIVFAFLWHTLVHEVLKKEGLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK0</accession>
    <name>E8MZK0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemerythrin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_25220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560903.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64548">
        <property type="protein sequence ID" value="BAJ64548"/>
        <property type="gene ID" value="ANT_25220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25220"/>
    <dbReference type="eggNOG" id="COG2703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086902_3_1_0"/>
    <dbReference type="OMA" id="WIITHIG"/>
    <dbReference type="OrthoDB" id="1991725at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12107">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016131">
        <property type="entry name" value="Haemerythrin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012827">
        <property type="entry name" value="Hemerythrin_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02481">
        <property type="entry name" value="hemeryth_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00550">
        <property type="entry name" value="HEMERYTHRINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="137" mass="16171" checksum="A72F86476DF08046" modified="2011-04-05" version="1">MAGKMFNFDVEFKLGIDSVDQEHQVLVDLLNQVYELIGEGKRDEARKYFNETLSRYVHEHFSHEEAFMEQIGFPQIEEHRKIHENFRNSFEALKPSIESADDTAFRKALNDAFTWIITHIGKTDKRYAQFYHASRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZL4</accession>
    <name>E8MZL4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560917.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25360"/>
    <dbReference type="EnsemblBacteria" id="BAJ64562">
        <property type="protein sequence ID" value="BAJ64562"/>
        <property type="gene ID" value="ANT_25360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25360"/>
    <dbReference type="HOGENOM" id="CLU_2010503_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="123" mass="13731" checksum="2011D79235B322AE" modified="2011-04-05" version="1">MENPQETPSSSKSSWDEVASELSALGNSLAKAFSALWTRVESSEEARQVKEGLESALQQVEQALKEAAETPEAQEVKLHARNTLEHLRTAGEQTVQEVQPQIVEGLQKLNDELEHLIEQLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN6</accession>
    <name>E8MZN6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64584">
        <property type="protein sequence ID" value="BAJ64584"/>
        <property type="gene ID" value="ANT_25580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25580"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037718_0_0_0"/>
    <dbReference type="OMA" id="DCLRSCC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="38"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="376" mass="43341" checksum="6D83F3BAAE0843CB" modified="2011-04-05" version="1">MPESSTLSFVLEQFFPSHQCLEIERIDNGHIHETLSARLQTPQGTQDVVLQRMNQHVFPHPEQVMENILLVTRHLQESYLAEGQNPEGRVLHFFATPSGEYLIRDSAGGVWRAAQKIPNARTYETTQDFKILFEVAWAFGDFQRRLISLEGTRLHETIPQFHHTRKRFNDFIQAVEQDASNRALSVRQDIEYLQRREDNVDIVVDALAKGHLPSRVTHNDTKINNVLMDRTSGNALCVIDLDTVMPGSILYDFGDLVRSAANTALEDEKDLSRVHFDVPRFIQLARGFLSAVREMLSPLEWELLAFAPRLITLEQALRFLTDYLQGDVYYRIAYPQHNLHRARTQIRLLQEMEQQAGLMESILERCKTDSTLGRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS0</accession>
    <name>E8MZS0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560973.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25920"/>
    <dbReference type="EnsemblBacteria" id="BAJ64618">
        <property type="protein sequence ID" value="BAJ64618"/>
        <property type="gene ID" value="ANT_25920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25920"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059362_3_0_0"/>
    <dbReference type="OMA" id="CAIAAYD"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="248" mass="28492" checksum="4C67F59FC25ED451" modified="2011-04-05" version="1">MRQFFEEFLKKTAYESLSRSPQEQGIPQPPLELPYSEEAILIPLPAPDTWSIPPADLRKTIEQRRSRRHYEPVPLTLEQLAYLLWLTQGVQKKSNRGVTLRTVPSAGARHAFETFLLINRVKELEPGLYRYIATQHALLRLDAPEDIRERMATACWNQEQVRQSAVTFFWVAVTERMAWRYVERSMRYLHLDAGHVCQNLYLAAESIGFGVCAIAAFHDQKINALLHLDGVDEFVIYIGSVGKPAISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU0</accession>
    <name>E8MZU0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62275">
        <property type="protein sequence ID" value="BAJ62275"/>
        <property type="gene ID" value="ANT_02410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02410"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823366_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="63"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="347" mass="39011" checksum="137263B7A408DF80" modified="2011-04-05" version="1">MSQPVAASASLCLLPRLEGLGGPASFRGRLSAALIRRGWQVHQNPDESACRAILVIAGTRDLPALWRARRRGVRIVQRLDGMNWLHRRRFTGVRHFLRSELNNALLAYIRRFLADAVVYQSEFSRRWWERVYGRVEHSAEVIYNAVDLQEYSPQGVEHPPADRWRLLVVEGHLHRGNWLGLENALVLARQLDGWQGKPAELWVAGDVAEELRRRAEELLPGKVRWLGIVPRRDIPALDRSAHLLFSAELNPPCPNAVIEALACGLPVAGFAEGGLPELVGGDGGVLAPWGSDVWKLQTPLSRDALAEFVRQLLIEGEAPRRRARARAERLFDLETMAEGYLRVLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU9</accession>
    <name>E8MZU9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62284">
        <property type="protein sequence ID" value="BAJ62284"/>
        <property type="gene ID" value="ANT_02500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02500"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158568_0_0_0"/>
    <dbReference type="OMA" id="FTHPAYG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="1">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="100" mass="11111" checksum="DD4226C71A52ACDA" modified="2011-04-05" version="1">MILKFLRVRGASLAPLLKDGDFVLASRLPLWFRPPRTGEIVVFTHPAYGRLIKRVAQILPNGSLIVRGTDIDSVDSRTFGAVQPHQVEGVVIARIARPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ6</accession>
    <name>E8MZZ6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative basic membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_02970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02970"/>
    <dbReference type="EnsemblBacteria" id="BAJ62331">
        <property type="protein sequence ID" value="BAJ62331"/>
        <property type="gene ID" value="ANT_02970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02970"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_1_1_0"/>
    <dbReference type="OMA" id="YDIIWAH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228519" evidence="3">
        <location>
            <begin position="31"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="60"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="344" mass="37466" checksum="AE95308F94C27BB8" modified="2011-04-05" version="1">MEENMKFNRFVSLLVLVLFVASLLAACAPAATPTAAPKSEKLKVFGAFATPIEEPWDGVIHAALIKAREEGKIDYEYTENIGYSGDMERILREVAEQKKPDIIFGDAFGNEEAVRRVAKDFPQIAFVFGSGLGPSDPNLSVFDNWIHEPAYLCGMLAGGLTKTGTIGVVGGYPVPEVNRLVNAFIRGAKEVNPNVKVLVTFINSWFDPAAAKEAALAQIDAGADVLYAERFGVIEAAKEKGLWVFGNMSDQNELAPDLVVSSPVWNMTPTVEYVLSQVKAGVYTAQDLKDFSMVAKGGASLAPFHNTESKLPPDLVAKVREREQQIKEGLFRVDIDENQPQAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N045</accession>
    <name>E8N045_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative M3 family peptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_03460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558777.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03460"/>
    <dbReference type="EnsemblBacteria" id="BAJ62380">
        <property type="protein sequence ID" value="BAJ62380"/>
        <property type="gene ID" value="ANT_03460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03460"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_3_0_0"/>
    <dbReference type="OMA" id="YQREVYR"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="116"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="201"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="591" mass="68444" checksum="9AD782351B7068A5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N053</accession>
    <name>E8N053_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558785.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03540"/>
    <dbReference type="EnsemblBacteria" id="BAJ62388">
        <property type="protein sequence ID" value="BAJ62388"/>
        <property type="gene ID" value="ANT_03540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03540"/>
    <dbReference type="eggNOG" id="COG1839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138382_0_0_0"/>
    <dbReference type="OMA" id="FGIAFCE"/>
    <dbReference type="OrthoDB" id="1392364at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="PTHR36155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="SSF103165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="162" mass="17556" checksum="40748A72769D85A3" modified="2011-04-05" version="1">MELSIVPIEKPEAVNFILGQSHFIKTVEDLHEALVAAVPGIRFGLAFCEASGKCLIRWSGTDEEMIELAKKNAMAVGAGHSFVIFLAEGFYPINVLKTVQAVPEVCRIFCATANPTQVIVAENGEGRGILGVIDGAKPKGIEGEEDIQWRKGFLRKIGYKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0C4</accession>
    <name>E8N0C4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561027.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26470"/>
    <dbReference type="EnsemblBacteria" id="BAJ64673">
        <property type="protein sequence ID" value="BAJ64673"/>
        <property type="gene ID" value="ANT_26470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26470"/>
    <dbReference type="eggNOG" id="COG2848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045053_0_0_0"/>
    <dbReference type="OMA" id="EMAIGMV"/>
    <dbReference type="OrthoDB" id="1419337at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="405" mass="43463" checksum="3754D7167251E64F" modified="2011-04-05" version="1">MKVRSVTCFFDPRSAQGYAHLDRLARLAQEAQTLFNNAGIEVQTTRLATVPFPLLYPTEEIGNAVRLAQSLEADARERGFSYLSLGPALPRFPASYDLIVPMLEATQNVFFGGVIATNTEGLSLPAVRACAQIIHRAAGLSPDGFANLRFGALANVNAHTPFFPAAYHNGERPAFALAVESADLALEALRRATSLQDARQRLITALEDTATRLTARATHLSQQFEVEFKGLDFSFAPYPADWCSLAGALETLGLPALGQAGSVASAAFLADALDRGRWLKTGFNGLMLPVLEDSILAKRAAQETLGVKDLLLYSCMCGAGLDTLPLPGDATPEQLEGVLLDIGAISLRLNKSLIARLLPVPGKHAGEAVQWDFEYFAPSRVMALPAAPLKGLLKGDEVVNIQPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E5</accession>
    <name>E8N0E5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative molybdenum ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_26680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561046.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26680"/>
    <dbReference type="EnsemblBacteria" id="BAJ64694">
        <property type="protein sequence ID" value="BAJ64694"/>
        <property type="gene ID" value="ANT_26680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26680"/>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065520_3_1_0"/>
    <dbReference type="OMA" id="VCAPQVP"/>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228579" evidence="4">
        <location>
            <begin position="25"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="269" mass="29004" checksum="682C43E14DB991BF" modified="2011-04-05" version="1">MMRKMLMILMSLLLLGLTGCGSPATSVASSQPVELVVFAAGSLTESFTEIGTAFEQKNDGVRVVLNFANASTLLQQITQGAPADVFASAAPKFIDDAVAQGLIEQDAVKIFARNRLVVILPKDNPKNIRAFQDLAKPGVRLILGAKEGPQGAYVEQLLINASSSPEYSSDFKERVYQNVVSYESTVKAVVNKVMLGEGDAGIVFFTDGKSAEDRLQLLTIPDEINVEAVYPIAVLKSSAHSELAQAFVDFVLSEEGQKIMEKYGFLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G5</accession>
    <name>E8N0G5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561066.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26880"/>
    <dbReference type="EnsemblBacteria" id="BAJ64714">
        <property type="protein sequence ID" value="BAJ64714"/>
        <property type="gene ID" value="ANT_26880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26880"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033063_0_0_0"/>
    <dbReference type="OMA" id="PYGWNTL"/>
    <dbReference type="OrthoDB" id="1841091at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="495" mass="54660" checksum="77304349DA0E646D" modified="2011-04-05" version="1">MPATLPLNDERSAARWVAVVVGVLIFLMAARTPLDSDLWWHLRAGEETLQSGKPVLTDIFSLTRYGTPWINHSWLGQVILAGLYRLGGYSALTVLVAGMAVLSLMLVYRQMSAPPLWRAFVVILAGLVCAPLWTARPQLFSLALFAVLFALLPALRAGRLSPFFVLPPLFAVWSNLHGGYALGFLLLGAVIAGQAVDRWLFPERACSWQSIARLAGAGGLAFLAVALNPNGIAMWKIPFQTVGVQVLQQAIPEWASPDFHDLTQQPFLWMLAGILLALGISRQRRTAEEMLPVLLFTALALMARRNFAPFALTAAPLLASTGWEALQNVFTPLSPALKRFSGESRPMRAKFRKIINLVSVAVLGFAAFLKAGLVSHPALVESLIRQHYPADAVAWIQTHPPQGNLFNEYAWGGYLLWRLPEHPVFVDGRTDLYGDSLLKEWLTIINAEEGWQSALEKWHIQWVLIAPDAPLARALKQAGWQTVYADEVAVIFEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G8</accession>
    <name>E8N0G8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_26910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26910"/>
    <dbReference type="EnsemblBacteria" id="BAJ64717">
        <property type="protein sequence ID" value="BAJ64717"/>
        <property type="gene ID" value="ANT_26910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26910"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025429_0_0_0"/>
    <dbReference type="OMA" id="THIPADG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="111"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="419"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="687" mass="76360" checksum="18077DD676721F38" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I6</accession>
    <name>E8N0I6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561087.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64735">
        <property type="protein sequence ID" value="BAJ64735"/>
        <property type="gene ID" value="ANT_27090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27090"/>
    <dbReference type="HOGENOM" id="CLU_402090_0_0_0"/>
    <dbReference type="OrthoDB" id="2123125at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="677" mass="77356" checksum="7B5F65E17EA3BF7F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S2</accession>
    <name>E8N0S2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ordered locus">ANT_04330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62467">
        <property type="protein sequence ID" value="BAJ62467"/>
        <property type="gene ID" value="ANT_04330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04330"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_4_0_0"/>
    <dbReference type="OMA" id="LIMARPF"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="230" mass="25187" checksum="C467278D8A5838EA" modified="2011-04-05" version="1">MIMQVIQVLGVLVVSYLLGSIPFGWIIVKLSTGRDIREVESGRMGGTNAMRAAGFLAGLLTAIGDIAKAYVTHWLVVWFIPADWGIRIWLEVAAPLMAILGHNYSIYLLTRHSDGTVKLRGGAGGAPCFGGTLGILPWSAYIILPIGVLVYVFVGYASVTTLSIAISATALFTYLTLTQGYPWQYILYGVFSFFILAWALRPNLKRLAEGTERAVGLRAYLQKRRQAQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U8</accession>
    <name>E8N0U8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_04590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62493">
        <property type="protein sequence ID" value="BAJ62493"/>
        <property type="gene ID" value="ANT_04590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04590"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_614885_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="223"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="445" mass="49901" checksum="8C7A10592BE766B3" modified="2011-04-05" version="1">MPSSRAMRDYSTANLFTLVLGTLLLITFIFLPWFGTAPAQNGARIFSDNLYQVPGAIPAPLIWLIPIATLGILGFGLWGILTPERDRLAALLAAFCAFLGLLYFARIFVEPSLLGGKATPGVGFWISLFSLLLTLFNLPITGPEVARLFQPRKGSRRGIDPRFIPYLFLIPSLTLYLVWIIGPTFYTFYLSLTNWDGVSTPGFIGFANFQRLFTRDRNFTEALVNNIRWLLIFISVPTTLGLLMAMIFNQEMWGSRFYKVSLYLPLVLSLPVIGLIWSWVYNPRLGLINSLLSLLGATDLPGWLGDRKLAIWCVIAAAVWRQVGYVMVLYLAGLKNVDPMLIDAAHVDGADRWQLFRHVIFPLLAPVTTIVVVISVIDSLRAFDLVAIMTRGGQSTQVLANFMYIEAFNNYRMGYAAAIAVVLFFLSMVFIGFYLSIVIRDELEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N112</accession>
    <name>E8N112_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">uvrC</name>
        <name evidence="10" type="ordered locus">ANT_05230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558953.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62557">
        <property type="protein sequence ID" value="BAJ62557"/>
        <property type="gene ID" value="ANT_05230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05230"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_0"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="256"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="620" mass="70667" checksum="F949FBBB2A56BBC2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A6</accession>
    <name>E8N1A6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_28230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561195.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64849">
        <property type="protein sequence ID" value="BAJ64849"/>
        <property type="gene ID" value="ANT_28230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28230"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="GETVFFY"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="34858" checksum="0CDA39186A36C6F7" modified="2011-04-05" version="1">MRDVIVTRDLTKRYGEFTAVDRLNLTVRQGEVFGLLGPNGAGKTTTILMILGLTEPSAGQIEVLGYDPARQPLTVKSRVGYLPDQVGFYDELTALENLHYIARLNGLNGKNAETRMQTALEKVGLQSVANKRVGAFSRGMRQRLGVAEVLLKQPEIIIMDEPTQGLDPEGAREFLQLVQSLKEEGITILLSSHLLHQVQAICDRVGLFNRGRMELVGTVDELARRVLGRAFRVVMEVDDITPELTKALKKVPGAVDVYPLEGKRLAVEASGEIRHEVAQAVIQSGRRLLGMYMEAQNLDEIYAHYFKEVEHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G4</accession>
    <name>E8N1G4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxymethylglutaryl-coenzyme A synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28810"/>
    <dbReference type="EnsemblBacteria" id="BAJ64907">
        <property type="protein sequence ID" value="BAJ64907"/>
        <property type="gene ID" value="ANT_28810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28810"/>
    <dbReference type="eggNOG" id="COG3425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_7_0_0"/>
    <dbReference type="OMA" id="EDTLTMA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01409">
        <property type="entry name" value="UPF0219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004656">
        <property type="entry name" value="FabH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00748">
        <property type="entry name" value="HMG_CoA_syn_Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III_C" evidence="1">
        <location>
            <begin position="226"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="353" mass="37607" checksum="19281979708E8BCB" modified="2011-04-05" version="1">MSGRVLKSNRPVGIIGYGAYIPRYRLPASEVSRVWEGGKGGGPVKEKAVAGLDEDVITMSIEAARNALARAQIDPTLLRAVWVGSESHPYAVKPTGTVVAEAIGAGPSIEAADWEFACKAGTEALVAALSLVGSGMGEYALAIGMDTAQGKPGDQLEYTAASGGAAYIVGPAENALAVFNGSYSYVTDTPDFWRRANQKYPEHGQRFTGEPAYFKHITEAGKALMEEMGTRPEDYRFAIFHQPNTKFPQRAGQLLGFTDEQIKTGLLAPVIGNTYAGAALVGLSAVLDVAQPGDRILVVSFGSGAGSDAFDWVVTEKIEARRNLAPSTADYIARRTEIDYATYARFRGKIDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I6</accession>
    <name>E8N1I6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">add</name>
        <name evidence="4" type="ordered locus">ANT_05570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558987.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05570"/>
    <dbReference type="EnsemblBacteria" id="BAJ62591">
        <property type="protein sequence ID" value="BAJ62591"/>
        <property type="gene ID" value="ANT_05570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05570"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_0_0_0"/>
    <dbReference type="OMA" id="RPQFKPY"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="352" mass="39968" checksum="2A2B775B87A2F44A" modified="2011-04-05" version="1">MGWYPRIPTGELSLYRAIPKVDLHRHLEGSLRLETLLDIARQHGLTIPQTHFHSLVQMQQDEPLTFTNFLSKFQTLRMFYRSPEVIRRITREAIADAAAENVRYLELRFTPVALSRLQGFSYDEVMDWVIQSAEEASREYNIKTRLIVSVNRHEPVDLAEQIVEYAIQRRERGIVGFDLAGNEVEFSALPFEGVFREAKKHGLQLTVHAGEWGGAENILEAIEFLGAERIGHGVKVLQTPRVLQAARERGIAFEVCITSNHQTGVVGAVRQHPLPQMVREGLKVTINTDDPGISRITLTDEYRVALEELGMPVAVFKDVVLNAARASFLPPEERQSLVETLEPELNRTLQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1J5</accession>
    <name>E8N1J5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial FdrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558995.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05660"/>
    <dbReference type="EnsemblBacteria" id="BAJ62600">
        <property type="protein sequence ID" value="BAJ62600"/>
        <property type="gene ID" value="ANT_05660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05660"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026233_1_0_0"/>
    <dbReference type="OMA" id="KARRWES"/>
    <dbReference type="OrthoDB" id="749518at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="2">
        <location>
            <begin position="190"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="1">
        <location>
            <begin position="340"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="574" mass="61647" checksum="29BA79F5DBFDF675" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K4</accession>
    <name>E8N1K4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559004.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05750"/>
    <dbReference type="EnsemblBacteria" id="BAJ62609">
        <property type="protein sequence ID" value="BAJ62609"/>
        <property type="gene ID" value="ANT_05750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05750"/>
    <dbReference type="HOGENOM" id="CLU_1648624_0_0_0"/>
    <dbReference type="OrthoDB" id="1615933at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="162" mass="18806" checksum="650E38C701FE5158" modified="2011-04-05" version="1">MDSNRSQHYNFVYEAIPVMFHSQTNQFMKYLERDGTKFLEFWWDHVGERLPEERLSDFKDVACEITPIDQQTKMAIIRLPVPTADREAYYIGLISRPERRFAWVRLPNTSVVCLIRREGDAFPNGTELVELTPSARVVSVGAGPLPEWEAFKQVLLKMVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z6</accession>
    <name>E8N1Z6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29170"/>
    <dbReference type="EnsemblBacteria" id="BAJ64943">
        <property type="protein sequence ID" value="BAJ64943"/>
        <property type="gene ID" value="ANT_29170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29170"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072993_1_4_0"/>
    <dbReference type="OMA" id="NVTFTPC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="14870" checksum="6E269A449EB724AB" modified="2011-04-05" version="1">MEGFMEIIRVGTQPSIKGSEDTFSGSVRIDRLFSAPEPAQVMVSSVTFEPGARTAWHTHPLGQILIVTAGCGRVQKWGGEVTEIRPGDVVWIAPGEKHWHGASPTTGMTHLAIVERCEGKSADWMEKVDNQDEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N208</accession>
    <name>E8N208_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561299.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29290"/>
    <dbReference type="EnsemblBacteria" id="BAJ64955">
        <property type="protein sequence ID" value="BAJ64955"/>
        <property type="gene ID" value="ANT_29290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29290"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_297126_0_0_0"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1014" mass="117006" checksum="2436C2BCB18C15E2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N215</accession>
    <name>E8N215_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_29360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561306.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29360"/>
    <dbReference type="EnsemblBacteria" id="BAJ64962">
        <property type="protein sequence ID" value="BAJ64962"/>
        <property type="gene ID" value="ANT_29360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29360"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_4_0"/>
    <dbReference type="OMA" id="RPHALQH"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="275"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="468" mass="53684" checksum="6FE906C28EF9329A" modified="2011-04-05" version="1">MFRRFSVNFAVFSILLDGALILGALIAATQLRVALNVLPFVKEIPAVQLPGVLYALFPMLWVGILLAFSVYDGRKNLRVVDELSSLTLASLLAVMSLAGILYFSYREVSRFLFLSATGSAYLLLVGWRLAARLAFRRNGLHRTIRRVLILGDNTVGRQLEEQIRAHPFLGLEIVGFLDDDWQTQADHHDVLGSLDAVRTWVQEKSVDDVVVALPLAAHQRLTEVVSELHDLPVRVWVIPDYFSLTLYRARVEDFAGIPMLDLRAPALNEFQRLVKRLFDLTLSVLILPFVLPLMGIIALAIKLDSPGPVLYRARRVGENGKLFYMLKFRTMVQDADKRLHEVMQTDEQGNLVYKRPDDPRVTRVGRFLRRTSLDELPQLFNVLRGEMSLVGPRPELPELVERYALWQRKRFAVPQGITGWWQINGRADKPMHLHTEDDLYYVQNYSLWLDLLILWRTFWAVLRRKGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N294</accession>
    <name>E8N294_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561382.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65041">
        <property type="protein sequence ID" value="BAJ65041"/>
        <property type="gene ID" value="ANT_30150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30150"/>
    <dbReference type="eggNOG" id="ENOG502ZB80">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064431_0_0_0"/>
    <dbReference type="OMA" id="WPEEIWI"/>
    <dbReference type="OrthoDB" id="1273060at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="27295" checksum="90937B58BE1E88B3" modified="2011-04-05" version="1">MTLSQPSGEERRVQFLGGASIDGAPVAYLIVLAAVVTVLAFIPFSAVLGMGGSFPMSQGVYSLVGWLLGPLAGAVSSGIGTLIGVFVAPHTTRVWYVSVMSALITSFAAGAMAAGGKRRLWWILPFVLGVLGFAVYVGRGLQNGVALSTALMTTFVNWSALILYLLPTRSLFSRWIASTHVAKMAAGLFLGTWMTYGLAHVCAGAITYLMFNWPAEVWMTLIPIIPVEFATRGAIGAVIGTGVIAGLRAIGLVKPTHAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A9</accession>
    <name>E8N2A9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30300"/>
    <dbReference type="EnsemblBacteria" id="BAJ65056">
        <property type="protein sequence ID" value="BAJ65056"/>
        <property type="gene ID" value="ANT_30300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30300"/>
    <dbReference type="eggNOG" id="ENOG50348XD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1871559_0_0_0"/>
    <dbReference type="OMA" id="VFLEREC"/>
    <dbReference type="OrthoDB" id="1973659at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="156" mass="18072" checksum="1DD756DBA94F2475" modified="2011-04-05" version="1">MFFLDVFLERECYNQIVPRQALFAGLVVDEFDQPVEVAYVGDEPCYVVNDRGFRRHIPAEEVDRQVLAWMREQMRGHEDLISEQTAHMLGQDDIFSRAMIEQQLKNIDQQFEQLLNVGIPEEGRAYLGMMGFRVVINLHGEVLRVDQPAMPSGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C6</accession>
    <name>E8N2C6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559126.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06980"/>
    <dbReference type="EnsemblBacteria" id="BAJ62732">
        <property type="protein sequence ID" value="BAJ62732"/>
        <property type="gene ID" value="ANT_06980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06980"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_4_0"/>
    <dbReference type="OMA" id="PDKPWFY"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="346" mass="38387" checksum="3A5C04FD97E0D8DF" modified="2011-04-05" version="1">MDEIRLGVIGLGMGRNHVAGFQSHPKARVVAVADMNERLLNEIAERYGVEKRYTSAEDMLAKEHLDAVSIATPNKFHAPLTLAAIAAGCHVLCEKPMAMNAIEAREMLDAAQKAGRRLMINFSYRFNEMSMALKQQVDAGLLGEIYFGRTVWHRRRGLPGFGGWFGQKALSGGGPLIDLGVHRLDLALWLMGYPKPVWVMGSTYQHLSLALAQKQGKTFDVEDLAAGMIRFENGATLMVEASWAANIKESEFMETRLYGTRAGLVQRNLDEGYRFEAEIFLEKDGAHFDMKLHPPYPPVTSSYYHFVDCLVTGKPHLATGEEGLRVMQILDALYQSAAEGGPVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D4</accession>
    <name>E8N2D4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559134.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62740">
        <property type="protein sequence ID" value="BAJ62740"/>
        <property type="gene ID" value="ANT_07060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07060"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_6_0_0"/>
    <dbReference type="OMA" id="PFGPCGE"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002850">
        <property type="entry name" value="PIN_toxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34610">
        <property type="entry name" value="PTHR34610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00305">
        <property type="entry name" value="TIGR00305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="15001" checksum="EF956B2C7B6DC8E9" modified="2011-04-05" version="1">MRIVLDTNVLVSALLNPFGAPGRVLDLILAGSVRMVYDDRILSEYREVLSRPRFGFEKQHVQRLMEYLIFTGEGVSAAPLAVAAPDLDDLPFAEVAVSGNADALVTGNPGHFSFVYHLPVLSPADFLQFWLEKQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F4</accession>
    <name>E8N2F4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein EutJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eutJ</name>
        <name evidence="1" type="ordered locus">ANT_07260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559153.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62760">
        <property type="protein sequence ID" value="BAJ62760"/>
        <property type="gene ID" value="ANT_07260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07260"/>
    <dbReference type="eggNOG" id="COG4820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088869_0_0_0"/>
    <dbReference type="OMA" id="HAGEIWP"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013366">
        <property type="entry name" value="EutJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02529">
        <property type="entry name" value="EutJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="29280" checksum="463DD44E0BB6E4DD" modified="2011-04-05" version="1">MNTNLHSFLQEAEKAIQRRSINGYRGQVHCGVDLGTAYVSMFVLTEDYQPLVGTYQFAEIVRDGLVVDFAGAVDLVRKMKADLESRLGFELTSAATAYPPGVPVAEVRATRYVLEAAGLNCSNLVDEPTAANAVLEVKDGAVVDIGGGTTGIAIIQNGEVIYTADEPTGGTHFTLVVAGALKISFHEAEEKKIDPSQQPVLYPLVRPVMEKVGSIIQRHIQPYAVDCIYLVGGSSAFIGFPKVIEGITGIKTVVPGNPLFVTPLGIAMNDRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F5</accession>
    <name>E8N2F5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BMC circularly permuted domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559154.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="SMR" id="E8N2F5"/>
    <dbReference type="STRING" id="926569.ANT_07270"/>
    <dbReference type="EnsemblBacteria" id="BAJ62761">
        <property type="protein sequence ID" value="BAJ62761"/>
        <property type="gene ID" value="ANT_07270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07270"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091281_0_0_0"/>
    <dbReference type="OrthoDB" id="1374667at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="2">
        <location>
            <begin position="109"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="207" mass="22698" checksum="A84D10AE631C7B2B" modified="2011-04-05" version="1">MADQFELRAYCYLDRMQPQYAAFVGTITQGDLPVEGMASLYVEMAPGNWVFRVVDIAVKATDVRPGAQIVEREFGMFEIHSLSQEDVIQAGQVVLEQLGLKITDRKKPEIASLQVITNVNPYQAQLLNRFARGMMLVPGQTMLVLECAPAAYINLAANEAEKAAPVNLMHISSVGRFGRLWMAGTEADILAARDAAVTALKEIEGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I2</accession>
    <name>E8N2I2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559181.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07540"/>
    <dbReference type="EnsemblBacteria" id="BAJ62788">
        <property type="protein sequence ID" value="BAJ62788"/>
        <property type="gene ID" value="ANT_07540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07540"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2505543_0_0_0"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="85" mass="9653" checksum="28753D5E17FE905C" modified="2011-04-05" version="1">MVDVATPLTFQRYTGNWRGSFEGWLMTPKEGFLRMKKTLTTVKNFYMVGQWVQPGGGLPSGVSTAREVIAQICREDGKRFQTFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I9</accession>
    <name>E8N2I9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559188.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07610"/>
    <dbReference type="EnsemblBacteria" id="BAJ62795">
        <property type="protein sequence ID" value="BAJ62795"/>
        <property type="gene ID" value="ANT_07610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07610"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_1_1_0"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="14933" checksum="08383EFEBB04B0D0" modified="2011-04-05" version="1">MEPIVSVTQHLVKSEDLNHHGTLYAGRTAEWFVEAGFIATAKVVPPEQIVCLQIHGMSFTSPVRRGEIVTFKGKVILTGKSRLITFVEMSASDRPVVKGFITFVNVNAEGKPLPHGVTIEPVTPEDIALQEEARKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J6</accession>
    <name>E8N2J6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltrans_SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559195.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07680"/>
    <dbReference type="EnsemblBacteria" id="BAJ62802">
        <property type="protein sequence ID" value="BAJ62802"/>
        <property type="gene ID" value="ANT_07680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07680"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_1_0_0"/>
    <dbReference type="OMA" id="YFPAIRQ"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="98"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="341" mass="38551" checksum="FC78168BFB1ED47D" modified="2011-04-05" version="1">MESDPLSSHLPALKRALDARAGLIQPPHRSALRLFAGFYEGWNDLVVDLYGSTLLLWNYADDPAWLTPETQQSLINFYRQHLPFLRAVWLKTRHALDQEGRTGTLIWGERPDRRIQEHGIWYAIDLGMHQDASFYLDTRNLRLWLKEHVTTETEVLNTFAYTGSLGVACLAGGAARVVQVDIDRKFLNLAKDSYSLNGLPIIKGDFLQEDFFHVAARMRRNGSEYDIVIVDPPYFSRTAGGEVNLVDECVRVINKARPLVRQGGWLIAVNNALFLSGKDYYSTLKALCADGYLAIEELLDVPEDITGYPSTRVNPPPVDPSPFNHPTKIAILRVMRKKTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Q2</accession>
    <name>E8N2Q2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isocitrate/isopropylmalate dehydrogenase family protein</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559250.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62858">
        <property type="protein sequence ID" value="BAJ62858"/>
        <property type="gene ID" value="ANT_08240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08240"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_0"/>
    <dbReference type="OMA" id="TCAHKAN"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="341" mass="37648" checksum="15D2774EB986CFC9" modified="2011-04-05" version="1">MKIYRIALLGGDGIGPEVIRAARRVLEALPLCWEWLEGEIGWGAYQRWGDPLPSETLTLIRQADATLFGAVTTPPDVPNYRSPVLRMRQELDLFANLRPCRSIPHPISRPDVHLLVVRENTEDLYVGRERLEENGETAVAEMVITRRASARIMRIACEQARQRRLPRVTLVHKANVLRQTSGLFRRVALEVGAEYPDLQVDEMLVDTCAMELIRAPQSFGVIVTTNLFGDILSDEASMLVGGLGLACSANIGEHTAVFEPVHGSAPALAGKNLANPLAAIGSAAMMLDYLGEDRWARCVELVIHRVIADRQVTPDLGGTLGTQDVAEAVIRYLQYVEEVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U5</accession>
    <name>E8N2U5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561436.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30690"/>
    <dbReference type="EnsemblBacteria" id="BAJ65095">
        <property type="protein sequence ID" value="BAJ65095"/>
        <property type="gene ID" value="ANT_30690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30690"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
    <dbReference type="OMA" id="WTLHRGN"/>
    <dbReference type="OrthoDB" id="1821409at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="254" mass="27420" checksum="2FE584587E6B1CB1" modified="2011-04-05" version="1">MELAGKTALITGGAVRVGKAITLALARAGANVVINYHSSQEEVVKTAREAEALGVRALPIRADVADRAQVETMVREAERQLGGVDVLVNSASPFLKTPFPVQDEQEWERWKKVLDVLIYGSLFCANAVAPGMKQRGVGVIVNILDLVLYEPWRDFTAHAMGKTALLALTRQLALELAPGVRVNAVAPGAVLAPEYLSEERRAAIAQRNLLGRWGRAEDVAEAVVFLARSDFITGEVLVVDGGERWNRLAADSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X0</accession>
    <name>E8N2X0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30940"/>
    <dbReference type="EnsemblBacteria" id="BAJ65120">
        <property type="protein sequence ID" value="BAJ65120"/>
        <property type="gene ID" value="ANT_30940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30940"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536026_0_0_0"/>
    <dbReference type="OrthoDB" id="401539at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228122" evidence="1">
        <location>
            <begin position="24"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="521" mass="56438" checksum="817A48EA17686D33" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y4</accession>
    <name>E8N2Y4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561475.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31080"/>
    <dbReference type="EnsemblBacteria" id="BAJ65134">
        <property type="protein sequence ID" value="BAJ65134"/>
        <property type="gene ID" value="ANT_31080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31080"/>
    <dbReference type="HOGENOM" id="CLU_1358120_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="201" mass="22492" checksum="1DE7D47CEC91CCBA" modified="2011-04-05" version="1">MPESMREILKKVERGELTPEQAEEYLRGETPPKEMPASPEEDIPPAAGEVLESPAEMDVRLNRWRLWWLIPLGIGGFILIVGIALITLGYAASSPFWFVCGFFPLFLGLLVVLLAVWSRGARWLHLRVREKGKVQIALSFPIPILLGKWFFTLFGGVIPGLRDQPGVAQSMPEMLDAVGKSREPLIVEVNDGDTEVRVYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y5</accession>
    <name>E8N2Y5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_31090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561476.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31090"/>
    <dbReference type="EnsemblBacteria" id="BAJ65135">
        <property type="protein sequence ID" value="BAJ65135"/>
        <property type="gene ID" value="ANT_31090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31090"/>
    <dbReference type="eggNOG" id="COG2962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054508_1_0_0"/>
    <dbReference type="OMA" id="HRMVWSL"/>
    <dbReference type="OrthoDB" id="1391352at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ65135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="297" mass="33212" checksum="3B9E8A0247CB5C8C" modified="2011-04-05" version="1">MKKGYVYAFLAYGMWGVFPLYWKALQNVPSVQILAHRVVWSLVFLVLLITLRREWEALRARLSPRVLGVYALSGALVTLNWGMYIWGVNANHVVETSLGYFINPLVNVLLGVVFLRERLRPGQWLAIGLALAGVLYMTFAYGRLPWLALALAFTFGIYGYLKKTFPLNSLHGLTLETGAVTPLMLGYLIFLETRGQGAFLHVSALESLLLALAGVVTATPLLFFGMGARLIPLSTMGLIQYLSPTMQFLLGVFLYHEPFDQARLVGFSVVWLALALYLAEGYWHQRRAEPKPEPAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N356</accession>
    <name>E8N356_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nuoH</name>
        <name evidence="7" type="ordered locus">ANT_08360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559262.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62870">
        <property type="protein sequence ID" value="BAJ62870"/>
        <property type="gene ID" value="ANT_08360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08360"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_0"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="337" mass="37240" checksum="43949EC110955E45" modified="2011-04-05" version="1">MDGAMILEWVLKSAFILLFMTAGFAYTTLFERRMIAKFQARIGPNRAGPWGLLQPVADGLKLIFKEELIPAYADKVMFVLAPVITVIPSLIVTAVVPWGGVVDLFGRKVALYLADVNVGLLYIMAVTSISVYGITLAGWASNNKYATLGGLRSTAQMISYEIAMGFSFIVPVLLAGSLSLVDIVEAQKKIWFIFLQPGAAIILAITMYAEVNRAPFDMPEAEQELTAGYHSEYSGMKFALFFMAEYIKMIAVAMIFATLFLGGYHFPFVDQIPVIGPYLGPFVLLAKTIVLLFGFVWVRSTLPRIRYDRLMAFGWKVLFPLSLLSVLVTAVVVLLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N381</accession>
    <name>E8N381_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHB_acc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559287.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08610"/>
    <dbReference type="EnsemblBacteria" id="BAJ62895">
        <property type="protein sequence ID" value="BAJ62895"/>
        <property type="gene ID" value="ANT_08610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08610"/>
    <dbReference type="eggNOG" id="COG5394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089210_2_0_0"/>
    <dbReference type="OMA" id="IRVIDNM"/>
    <dbReference type="OrthoDB" id="1665699at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012909">
        <property type="entry name" value="PHA_DNA-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07879">
        <property type="entry name" value="PHB_acc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB_acc_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="175" mass="20275" checksum="C0BDEEAD3EDBA912" modified="2011-04-05" version="1">MPLIKRYHNRKLYDTASRSYVTLEQIARMVRRGEDVRVVDHESGSDITSLVFMQILLEEQKRVGELFPQVVLLRLLRSGEDTLDALRERLLAAFDPQGFLHHAVRRRIRQGVEQGEISPPEAEKFLRMWFGESSLEEFPAEPTSSSGKDTLEQLQTQLRALEDELQRLQNSLQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N390</accession>
    <name>E8N390_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08700"/>
    <dbReference type="EnsemblBacteria" id="BAJ62904">
        <property type="protein sequence ID" value="BAJ62904"/>
        <property type="gene ID" value="ANT_08700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08700"/>
    <dbReference type="HOGENOM" id="CLU_319501_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="909" mass="95194" checksum="080A5C38CD98EEBE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F6</accession>
    <name>E8N3F6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rho</name>
        <name evidence="11" type="ordered locus">ANT_09360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559361.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62970">
        <property type="protein sequence ID" value="BAJ62970"/>
        <property type="gene ID" value="ANT_09360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09360"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_4_3_0"/>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="49"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="164"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="176"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="425" mass="48008" checksum="EC7D1F6794460D58" modified="2011-04-05" version="1">MMNILELEKEPLSKLRQLGDELNIPNAHRLKKEMLLIKIRQVEAEREGLEVRGGILEIMNEGIGFLRSDYRVGSDDVYVSQAQLRRYELRSGDLVIGHVRPPREGERHYGLVKVESINGLPPEEARRRPNFENLTPIFPDKRFDLETDRNILATRLINLIAPIGRGQRGMIVSPPKAGKTTILKQVANAISRNYPEVHLMIALIGERPEEVTDMDRSVDGEVIASTFDEPVTSHVRAAEIALERAKRLVEVGRDVVILMDSLTRLARAYNLVVTPSGRTLSGGMDPSALYPPKRFFGAARNLEEGGSLTIIATALVDTGSRLDDVVYEEFKGTGNMELHLSRRLQERRIFPALDIERSSTRREDLLLSPDELQRVWLMRRMYLQMTGTPPQGAGMDPAVATEAILQRMIKTRNNMEFLETLTEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F8</accession>
    <name>E8N3F8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559363.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09380"/>
    <dbReference type="EnsemblBacteria" id="BAJ62972">
        <property type="protein sequence ID" value="BAJ62972"/>
        <property type="gene ID" value="ANT_09380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09380"/>
    <dbReference type="eggNOG" id="ENOG502ZJIW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828068_0_0_0"/>
    <dbReference type="OrthoDB" id="2129327at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228140" evidence="2">
        <location>
            <begin position="30"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="335" mass="36357" checksum="06201AFAB5FD7C7C" modified="2011-04-05" version="1">MKRWTTFFTVFLMTLILTGCVLPSSTPPAGENVKPTLSDVEMQTQIALMLTTMPTATPEHVTQPTATLPPVVTASEPQPTPVPTETPLPQAPTATPLPPTPTEVSTQAAPTATATPAGPTPTTGPTPTVSPDDPRNRLGNPSDIDPMNDETAWNWPTGYSEFTSIEFRNGQMLFKGLQTKLGWRLANPRGEAFSNLYLEMVVKTESCTGNNQFGMIVRVPVLKDANQGYLFGVRCDGKYSLRKWDGTLGEKGTLTRLKDWTSSNAINTGANATNRLGLMMLGNRLIMYVNGTLLGEVSDDTFPNGYFGVYAASDSSSEPFTIAVEEMSYWLNPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G5</accession>
    <name>E8N3G5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559370.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62979">
        <property type="protein sequence ID" value="BAJ62979"/>
        <property type="gene ID" value="ANT_09450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09450"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908053_0_0_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225449" evidence="1">
        <location>
            <begin position="28"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="306" mass="33962" checksum="16D292C7A1B8FD59" modified="2011-04-05" version="1">MRRALFALLVFFLLTACGLVPGLPAPAAPQEPTATPLPTSVAPEFPTIPDRSCLLATLEPIRTNQQQGNLMVWHPEEMTLAYVAPKGRSIWFTGEILLSSGSDYKTSTVLFENTSVFGDLTWSPSGKQLAFVALRQPENVYTVMVTNLETQQTVDILPGEQATLTSGSGSKGIVEWLSENQIRIIASCGADCDVMLDVNLSSGQVVPYGETMRHQADRLSPTRKTLSYDEKTYPPMLSPNWSPDGKKVAYFDDLDQAWVLLTQEKAQFLLDIGLQTPYESQWASDSRILALRTDDFIFLFDTECRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Q1</accession>
    <name>E8N3Q1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rpoA</name>
        <name evidence="13" type="ordered locus">ANT_10310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63065">
        <property type="protein sequence ID" value="BAJ63065"/>
        <property type="gene ID" value="ANT_10310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10310"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_0"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="250"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="321" mass="35306" checksum="8ED4C90A69BB2F26" modified="2011-04-05" version="1">MAALTNMVTPKVEREAEARNYGKFIIGPLEGGYGVTLGNALRRVLLSSLEGAAVTSIRISDVLHEFSDIPGVREDVIQVMLNIKQLRLILHDVETTHMHLEVRGEGTVTAADIQAPAEVEIVNPELELFTVDDPNTRLEIDFTVSRGRGYSPASERSGRLPIGELPVDAIFSPVKRVNWSVTAARVGQSTNYDRLILEIWTDGTITPENALSTSAKILIDHLRYITGVSAESLAVTVEKEVAGGRLTSEAAETPIENLDLSVRVFNSLKRTGITTVGDVLELLEKGEDAVMSIRNFGEKSLDELRQKMREKGFLRDEKTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W6</accession>
    <name>E8N3W6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_10960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63130">
        <property type="protein sequence ID" value="BAJ63130"/>
        <property type="gene ID" value="ANT_10960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10960"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="DVFTTHR"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="366" mass="41209" checksum="FE87056FB3007E14" modified="2011-04-05" version="1">MEDNMESKSKDLFIEVKDLHVEFDVRAGIVKAVDGMFLEIRRGQTVGVIGESGCGKSVTARAIMNMIPKPGKITGGEILYHRRNRETGEVQTIDITKLDPDGEIIRQIRGGEIGMIFQEPMSSLTPVYTAGQHIHEAVSLHRLIPVKKLGDQMVETIVAHRKVTKEEAREIAIEMLRKVGIPKPEQRVDSYPHQLSGGQRQRVMIAIALSCQPEMLIADEPTTALDVSIEAQILDVMRDLQNTMDMAIMFITHNLGVVAEMAEEIVVMYMGKQVERARVVDLFYKPKHPYTQALLRSIPRIGKKSDVRLATIEGMVPDPFHLPTGCVFHPRCPMFMPGKCDKIEPSNIQVDDHHWARCLLYEEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W8</accession>
    <name>E8N3W8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559522.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63132">
        <property type="protein sequence ID" value="BAJ63132"/>
        <property type="gene ID" value="ANT_10980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10980"/>
    <dbReference type="HOGENOM" id="CLU_2128265_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="113" mass="12578" checksum="46F0B63FAE0FCE16" modified="2011-04-05" version="1">MNESPLTGWKMVRSVLLSLLAFLVWLATAALGLVEIFLVRQTTLRIFARFSNETAVGTALGNWVAFFAAGTWLAYVVFAAETQFRKKSLGEGWNLFAWGAAIELLILVLYFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N489</accession>
    <name>E8N489_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate 5-kinase</fullName>
            <ecNumber evidence="8">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyl kinase</fullName>
            <shortName evidence="8">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proB</name>
        <name evidence="10" type="ordered locus">ANT_12190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559641.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63253">
        <property type="protein sequence ID" value="BAJ63253"/>
        <property type="gene ID" value="ANT_12190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12190"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_0"/>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="279"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="213"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="377" mass="41466" checksum="3E6A7106BA407BE2" modified="2011-04-05" version="1">MRKGKRIVVKVGTSTLTDGGRRLSPPRMVDLARQIALVRSKGVDIILVSSGAIAAGREVLNYPELPRFIPKKQMLAAVGQPRLMAMYTEYFAIYGQRVAQVLLTRADLMDRKRYLNARDTFEALLLQGILPIVNENDTVATEEIRFGDNDTLSAQVAALVEADDLILLTDQAGLYEADPRVVPGARLIREVPAEEIPDTLWEAAGGSRSGLGTGGMLTKLRAADLARRSGTTVWIAQGNEEDIIIRIVNNEKLGTRFAPMISHLEGRKRYLLAGHQVQAGVWIDKGAARALSRGGSLLPVGIIRVEGEFERGDTIRILNEQGKLIALGLTYYSSSEVQRFAGKHSDQIESILGYTFGEEVVHHNHMVFMRNGEHESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A9</accession>
    <name>E8N4A9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative [LysW]-aminoadipate kinase</fullName>
            <ecNumber evidence="6">2.7.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argB</name>
        <name evidence="6" type="synonym">lysZ</name>
        <name evidence="8" type="ordered locus">ANT_12390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of LysW-gamma-alpha-aminoadipate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP</text>
            <dbReference type="Rhea" id="RHEA:41944"/>
            <dbReference type="Rhea" id="RHEA-COMP:9694"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78503"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetylglutamate kinase family. LysZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.17" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559661.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63273">
        <property type="protein sequence ID" value="BAJ63273"/>
        <property type="gene ID" value="ANT_12390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12390"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_2_1_0"/>
    <dbReference type="OMA" id="EMVYCGK"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043744">
        <property type="term" value="F:N2-acetyl-L-aminoadipate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02082">
        <property type="entry name" value="LysZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037529">
        <property type="entry name" value="LysZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="267" mass="28660" checksum="F70960275EC4D203" modified="2011-04-05" version="1">MIVVKIGGSQGVNLDTICADAASLIQQGEQLILVHGGSAEVNEISTQLGHPPRFVTSENGFTSRYTNRTTLEIFAMVTAGKINTLIVERMQKHGVNALGLSGVDGRLMRAQRKEAIRIVENGRKMILRDDYTGKIETVNTNLLQLLLENGFTPVIAPLALSQQGEAVNVDADRAAAMIAGSVHAEQLIILTNVPGLMRHFPDESTVIPRLSRAELDSALSFAEGRMKKKVLGASEAIHLGVPRVIFADGRTEHPLLDALAGKGTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D8</accession>
    <name>E8N4D8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63302">
        <property type="protein sequence ID" value="BAJ63302"/>
        <property type="gene ID" value="ANT_12680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12680"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_3_0"/>
    <dbReference type="OMA" id="YLYGVCT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="139" mass="15631" checksum="E2AFF76431BBC93D" modified="2011-04-05" version="1">MPEKEPTQMLHQQGYRVTPQRLAILSVLEETDGHLTATEVYERARKILPAVTEATVYRNLDFLVNQGLVLMAHVGSGKMVYESTRHAHHHLICRKCGTSQEIPHALLQSLFEELSTLSGYQIDSLHVTFFGLCPGCQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J3</accession>
    <name>E8N4J3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gap</name>
        <name evidence="10" type="ordered locus">ANT_13250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559744.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63357">
        <property type="protein sequence ID" value="BAJ63357"/>
        <property type="gene ID" value="ANT_13250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13250"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_0"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="349" mass="37487" checksum="93C7E0A7D113A3BE" modified="2011-04-05" version="1">MTVKVGINGFGRIGRQVLKAIMERYPNELEVVAVNDLFDAKTNAHLFKYDSNYGIFNGTVEVSGTDLVINGKTVKVLAEKDPAKLPWKDLGVDIVIESTGVFTDALGDPAKGKAGANAHLQAGAKKVIISAPAKNEDITIVMGVNDDKYDPAKHHIVSNASCTTNCLAPAAKVVHEKFKILNAVMVTIHSYTNDQVILDQGHKKEMRRSRAAGLNIIPTTTGAAKAVALVIPDLKGKFDGYALRVPTPTVSIVDFTATVEKATTKEELNAAFMEAANGALKGILGVTTGEYMDPLVSMDFKGDSRSSIVDLPSNMVMGGNLIKVVTWYDNEWGYSCRTADLAAMMAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K2</accession>
    <name>E8N4K2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_13340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63366">
        <property type="protein sequence ID" value="BAJ63366"/>
        <property type="gene ID" value="ANT_13340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13340"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_288318_0_0_0"/>
    <dbReference type="OMA" id="FGGDPYW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225473" evidence="4">
        <location>
            <begin position="32"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="5">
        <location>
            <begin position="54"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="942" mass="103414" checksum="FF3E09FFCFD8056D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L3</accession>
    <name>E8N4L3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ordered locus">ANT_13450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559764.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13450"/>
    <dbReference type="EnsemblBacteria" id="BAJ63377">
        <property type="protein sequence ID" value="BAJ63377"/>
        <property type="gene ID" value="ANT_13450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13450"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_6_1_0"/>
    <dbReference type="OMA" id="AYNLWIS"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="202" mass="22327" checksum="DB6A8A36C44FF650" modified="2011-04-05" version="1">MNSSVEFFLWTTIAFLSGSIPFSFLLGKWLFHTDIRTYGDGNPGATNLIRAGGKWSGALGLVLDALKAAIPVGWAYFVLHPPFLWMLLISLAPVLGHMFSPFLRGKGGKAIASTFGMWIGLSLGEVPTILGLFMVLGIFALEPHAWVVLFSLLGTFLYLILYHPDPLFLSVWVLNTLLVLGKHARELRTAPQLRAVLRRHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4M3</accession>
    <name>E8N4M3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13570"/>
    <dbReference type="EnsemblBacteria" id="BAJ63387">
        <property type="protein sequence ID" value="BAJ63387"/>
        <property type="gene ID" value="ANT_13570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13570"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462064_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="590" mass="62895" checksum="8CD2F8D3D15C60CF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S9</accession>
    <name>E8N4S9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional phosphoglucose/phosphomannose isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
            <ecNumber evidence="3">5.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EC" id="5.3.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559825.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63443">
        <property type="protein sequence ID" value="BAJ63443"/>
        <property type="gene ID" value="ANT_14150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14150"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059687_0_0_0"/>
    <dbReference type="OMA" id="FPELNHN"/>
    <dbReference type="OrthoDB" id="1179564at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05017">
        <property type="entry name" value="SIS_PGI_PMI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05637">
        <property type="entry name" value="SIS_PGI_PMI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035484">
        <property type="entry name" value="SIS_PGI/PMI_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="37"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="38774" checksum="5DDB0485E2CB45C9" modified="2011-04-05" version="1">MNLDDVTAFQQIDSQDMIGQINGLPDQLNRAYELGKTFPLPEKRKFHSVLISGMGGSAIGADLVASYLQDKISLPIIVHRDYELPLWAGEDTLVVASSHSGNTEETLWAYDQARQRGCAIVAICTGGKLAGLARKDGVPLWQFDHRHAPRTAVGFSFGLLLALFEQLGLISSVEQEVDEAVHAMRNVQTNLGIDVPVTHNPAKRMAGQLFGRWVVVLAADYLAPVARRWKGQINELAKAWAQFEFLPEADHNTLAGLENPSAMLMNMMALFIQAPGINSRNQKRIELTREMFMTQGINTDMIVARGEGKLAHIWTSLLFGDYMAYYLAMAYGIDPTPIPILDAFKSEMASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U2</accession>
    <name>E8N4U2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pdhC</name>
        <name evidence="8" type="ordered locus">ANT_14280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559838.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14280"/>
    <dbReference type="EnsemblBacteria" id="BAJ63456">
        <property type="protein sequence ID" value="BAJ63456"/>
        <property type="gene ID" value="ANT_14280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14280"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_0"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="427" mass="45855" checksum="4F19B93D886CF174" modified="2011-04-05" version="1">MAETIKMPKLGFDMQEGTLVRWVRQEGEAVEKGQVLAEIETDKATVEVEASVSGIVHRHLVEQGAVVPVGTPIAIIAAPGETVAEEPVAGVLPAKNVEEAAEKEAVSLAQPSVSGEEQRIKASPLAKRLAKEHQVDLNAVQGSGPGGRIVRKDIEAYLAMIRTAVPQAVEVPIPTPSVSTSPAPSSGFTLPVWTAPESVPADETVPMDRLRQAIGRRMVDSKQNYPHFYITRSFNVEALMALREQINQVMPEGQKLTLNDFVIKAVALALRSYPNLNASISGNAILRHGRVNIGVAVAVEGGLLTVVCKDADQKPLRVISSEIRDMVSRARQGKVRPEDIEGSTFSISNLGMFDVENFMAIINPPESGILAVGAAQKVPVVVGDEIKTGLRMKATLSADHRVTDGAEAAQFMQVLARYLENPILLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U7</accession>
    <name>E8N4U7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ordered locus">ANT_14330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559843.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63461">
        <property type="protein sequence ID" value="BAJ63461"/>
        <property type="gene ID" value="ANT_14330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14330"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_0_0"/>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="17194" checksum="1C0D3A65AFDC7F49" modified="2011-04-05" version="1">MIYFFVDEAYEALVRKEPLIRAAEETLRVENHSDSDVTISIQNDEALKSLNAQFMGTEAPTDVLSFTMDFFDPETERQYLGDILISYERAEEQAQTAGHSTENELILLIVHGILHLVGYDHGTEEEKSKMWKTQSEILKQLGCEIKRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N515</accession>
    <name>E8N515_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63529">
        <property type="protein sequence ID" value="BAJ63529"/>
        <property type="gene ID" value="ANT_15010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15010"/>
    <dbReference type="HOGENOM" id="CLU_129205_0_0_0"/>
    <dbReference type="OrthoDB" id="1890737at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="15618" checksum="99C39C57BA1717AD" modified="2011-04-05" version="1">MSRKIATRFLIGLVFFWNIQAAIVFLAFPREYLSSFILSGKVGEKVIQSWGILFIMWNIPYFMAMLNPEKERGLVLACLLMQLVGVVGETFLYVDLSEQFFTVKQSILRFIVFDGAGLLFLFIAWWLSRDQSTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N521</accession>
    <name>E8N521_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_15070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63535">
        <property type="protein sequence ID" value="BAJ63535"/>
        <property type="gene ID" value="ANT_15070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15070"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582214_0_0_0"/>
    <dbReference type="OMA" id="HISECNG"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="469" mass="53127" checksum="BF46E8DE95F3A0FC" modified="2011-04-05" version="1">MNMEDNTVESQTQVSVIFLYSDHLKKPAFESIHQELEADRRAILEKLSEKYRICSHWVVSTNQDLLSFVQAFQSDESDIVILLYQTQVEELHIQELVAAVGKKPLVTWCYLPWKRAPKPLSYEEYLRASGAASMFVAFYELRKRSVPYLPVFGSIQDADLLHKLDAFIQSARVKTQLRRANIAVLEHTGVKTDEIFKEFQELGITLKEVHLTEYQEEVTKVSEDEVAEYVQQLREHVPDLMVTIPTLQLGAKLSVALRRVAFQNNLDVLALPAHSAEIRKALKICPGLPPEWSDNPHTIYLTTLDPGAILSSVLLRLVTGQVGFLFKAWFWDKARNILVGGHTGLQFPNISAPKLSLVCGDYYCNRADPDGGVQLEFIAKPGRVTMLQMEYRSDGWKALITSGMCLESELWVEGLPQAVIRPDCTIDHYLDVVSATGSGRNWVMIYGSVIDELKALFELMQIPFDIIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N534</accession>
    <name>E8N534_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ca(2+)/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_15200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15200"/>
    <dbReference type="EnsemblBacteria" id="BAJ63548">
        <property type="protein sequence ID" value="BAJ63548"/>
        <property type="gene ID" value="ANT_15200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15200"/>
    <dbReference type="eggNOG" id="COG0387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_2_2_0"/>
    <dbReference type="OMA" id="AAVMITC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="PTHR31503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="33"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="213"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="359" mass="37816" checksum="F9CB5BA67F7ECA23" modified="2011-04-05" version="1">MKKFLAIIRKPINWLIVALPFALFADLFHWGDFWIFIFSCIGIIPMAGLIGEATESLSIYTGPKIGGLLNATLGNAAELIITLVAIQAGLLELVKASITGSILGNLLLVLGASIFLGGLKHGVQSFDRRQAANHAILLIIVVIGLAIPSLFSHSIGPDDSVEVEALSIGVAIVLMLLYSLGLIYTLKTASSPISYSPADATVHQHGLTKGEAIIVLALSTLAVVWLSELLVGAVEHVVSNLGISEFFLGIILIPLVGNVAEHLVAVQVAMKNQMDLSVEIAVSSSLQIALFVAPVLVFISLLMGNPLTLVFNQFELIALIAAVVVAALVSSDGESNWLEGAALIGVYLILGVGFFLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N559</accession>
    <name>E8N559_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_15450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559955.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15450"/>
    <dbReference type="EnsemblBacteria" id="BAJ63573">
        <property type="protein sequence ID" value="BAJ63573"/>
        <property type="gene ID" value="ANT_15450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15450"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_8_1_0"/>
    <dbReference type="OMA" id="GILHTDH"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="35503" checksum="DC778B0307B9C571" modified="2011-04-05" version="1">MLVIYKNTEAGLEEITEAVTGCWINVIDPEQEEIEQLVELGVPQDFITYALDLDEQSRAEKEDDGTLLVLLRIPYFQGAKMDVPYRTIPLGIVITSRFIVTICRLQNDIIQEFCSGRIKGLSTAKRNRFTLRVLLSTASKFLLYLKEINKVVETLEDLITLSSRNRDILELLKYQKSLVYFTTALRANELMMERLQRWQIFKAYPDDEDLLEDVITENRQALEMVEISSNILSSMMDAFASMISNNLNEVMKFLASITIILSIPTIVTSFFGMNVDLPVQDHPLAALFVIIISIVISAVVVSIFRRRDWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N565</accession>
    <name>E8N565_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NarL family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_15510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559961.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63579">
        <property type="protein sequence ID" value="BAJ63579"/>
        <property type="gene ID" value="ANT_15510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15510"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="DDPMMQL"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="217" mass="24026" checksum="202988F87E41C298" modified="2011-04-05" version="1">MSIRVLIVDDQSLFREGLKTLLTAQKDFEVVGEASNGEEALRLIANNHPHVVLMDLRMPVLDGVRATGRIRELFPEVRVIILTTFDDDDLVFDGLRAGAIGYLLKDVSSDNLFEAVRAAYRGEYFLQPSITAKVVAEFARSPRPSSAKMAELTEPLSPREIEVLFLVAEGKSNREIAEQLVISEGTVKNHLSSILSKLGAKDRLQAVIRAREAGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L5</accession>
    <name>E8N5L5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_17030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560108.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63729">
        <property type="protein sequence ID" value="BAJ63729"/>
        <property type="gene ID" value="ANT_17030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17030"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_9_1_0"/>
    <dbReference type="OMA" id="GVQAFYF"/>
    <dbReference type="OrthoDB" id="1825365at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="155"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="36099" checksum="A4CFE24586E8EBED" modified="2011-04-05" version="1">MNTSHSKGYVIALVGTLLWSATAVFIRYLNLEYKIPVLILAFWRDLFTAGIVFLAMALLKPSLIQKGFSHVRFFLGYGALLAVFNFLWTFSVFLNGAAISTVLAYSSAAFTAIFGWLLWREELHLPKIMAVVFSIIGCILVSGAHQVQQWTSNPIGILTGLLSGIAFAGYTLLGRLASQKRIPTPTVLGYTFLTAALLLLMANAFFPLKWIDSRNLLWLGNRWDGWMVLFLLALIPTIGGYGLYTFSLNFLPASIANLIATLEPSFTALQSYLLLGERFTSDQILGSVLILLGVILLRLNEIRQSNQERRTAYETTSSQTPVIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L7</accession>
    <name>E8N5L7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560110.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63731">
        <property type="protein sequence ID" value="BAJ63731"/>
        <property type="gene ID" value="ANT_17050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17050"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_0_3_0"/>
    <dbReference type="OMA" id="IPHPYEY"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="379" mass="42604" checksum="0877F1ED40978E98" modified="2011-04-05" version="1">MEWRVPLADLDYGPEEADAVLNVLKRKWLTMGEITQDFERAFAEMHGAKYAFGVANATVALHLACLALEIQPGDEVIVPSLSFVATSNAVLYTGANVRFADILGLENLTVDPEEIRQKITSRTKAIIVMHYGGYPCQMEEITRIAREYNLVIIEDAAHAPGASLNGKPLGIWGDIGCFSFFSNKNLSTGEGGMVITNREDLAEKIRLLRSHGMTTLTYDRHRGHAFSYDVLSLGYNYRIDEIHSALGIAQLQKLSRNNALRRQWTDLYRQELADLPLVLPFTSTPGESACHLFPVLLPAKASRERFMQFMREQGVQTSIHYPPIHSFSYYREKYGHLSLPRTEMVGLREVTLPLYPTMGEEKVKTVVQAVRKALQNAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q4</accession>
    <name>E8N5Q4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_17420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560146.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17420"/>
    <dbReference type="EnsemblBacteria" id="BAJ63768">
        <property type="protein sequence ID" value="BAJ63768"/>
        <property type="gene ID" value="ANT_17420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17420"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="AEGTTEC"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="38182" checksum="8E4F29634CDD568E" modified="2011-04-05" version="1">MVSATRHPTLHDVARLANVSHQTVSRVINNSPNVASETRERVLEAIRILDYHPNRAARSLITGRSQTLYLVHLNPRFLAPVPAIIQHADERGYRVGLSMLKEPVSRDELQNLLNEVSSRIVDGFLFIDPQGIYTAEELNRFCRGVPYIQLGGEPVEHVPAVLFDQEQGMRAVLRHLAQLGHQKIAEVSGLMINYDARMRHRAVEGIAREYGLELVDWLEGDFTVPSGYQLTRQLLKNNGKRFSALICGNDLMALGALRAIHECGLRVPYDISVVGFDDELISSFFEPPLTTVKQDYNEQARVGIEYLLDRIEKRNFSIEHKRISPQLIIRSSTGEINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q7</accession>
    <name>E8N5Q7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17450"/>
    <dbReference type="EnsemblBacteria" id="BAJ63771">
        <property type="protein sequence ID" value="BAJ63771"/>
        <property type="gene ID" value="ANT_17450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17450"/>
    <dbReference type="HOGENOM" id="CLU_1217772_0_0_0"/>
    <dbReference type="OMA" id="ESKEWAN"/>
    <dbReference type="OrthoDB" id="642086at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228190" evidence="1">
        <location>
            <begin position="27"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="227" mass="25705" checksum="BE3B3522C4843EAA" modified="2011-04-05" version="1">MPLMEKKMKKYWFIILAVCASLLFSACQPQHENPSQMPSPYPSGEIPNPYQHPYPPFEPAEEEQLVKTVLQKVSDILGKPQEVLKVQKVESKEWANACLELPHPDETCAEMIVNGYRIQLLVEGKTVFVHTNQDGSVVRIAGENEMGDISDKAKNYLVEKLGIPTEEITILEVQEVEWPDSCLGVVQPDQMCLQVITPGYRIVVEVKGKKIILHTDREGKRILQAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V9</accession>
    <name>E8N5V9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ordered locus">ANT_17970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560201.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63823">
        <property type="protein sequence ID" value="BAJ63823"/>
        <property type="gene ID" value="ANT_17970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17970"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_0"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="133"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="470" mass="52873" checksum="E5986CB69984309E" modified="2011-04-05" version="1">MANSPQNEFLEALDQYRYGFSDPETYVFKSRKGLDREVVEQISRMKGEPQWMLEFRLKALDHFLKRPMPTWGADLSDLDLNDIYYYVKPTDKEGRSWDDVPATIKETFTRLGIPEAEQKFLAGVGAQYESEMVYHSIQEHLEKQGVIFLSIEDGLRKHPDLFREYFGTVVPIEDNKFAALNSAVWSGGSFVYVPKGVKVDLPLQAYFRLNVANIGQFERTLIIADEGAQVHYVEGCTAPQYTTDSFHSGVIEIVVKRGARVRYTTIQNWSNNVYNLVTQRAVVYGDGVMEWVDANLGSKVTMKYPSCYLMEPGARGEILSIAFAGKGQHQDAGGKVIHFAPHTSSKITSKSISKSGGRTSYRGLLKVYKGAEGVRSNVVCDALLLDDKSRSDTYPYIEIDEEDVTIGHEASVSKVGEEQLFYLMSRGLSEEEATTMVVSGFIEPLVKELPMEYAVEMNRLIQLQMEGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N602</accession>
    <name>E8N602_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560243.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63866">
        <property type="protein sequence ID" value="BAJ63866"/>
        <property type="gene ID" value="ANT_18400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18400"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518432_0_0_0"/>
    <dbReference type="OMA" id="AFLAHWA"/>
    <dbReference type="OrthoDB" id="1603070at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="507" mass="57542" checksum="F9579D289932BCAD" modified="2011-04-05" version="1">MRTKFRLSSTILVLLIAFFPYFLGWATQGNFIFSGLLFNPQDGFSYLAKMRQGWDGSWGFTLPYTASPGEPVPLFLFYLFLGHLAKAFHLPLPIMYNIARFLSSAFLLYMLGDFLDRMFGKQFQEARVLFWILALGGGMGWLVVLMTGFLTGDFWVAEAYPFLSIFATPHFSLGLALILLGDKVSTLPLRATNGLALSLLSVLLALIQPFGVVILGLWVGVRFLVSVLYRKEWQMGVRMLQILPGALILLWQFWIIASHPVLRLWNNQNVTEALPLWDLILSLSPVIFLALVGGWKALRKKDIPFVILLGWMIGAILLTYTPFNLQRRFMTGIYIPVAVLGAYGISEWLEHNTVLKKWLWRGLLITSILTPLLVIFSSTVAVLQKDSLIYINSDEFRAIKWMDLNLPENSVVLASPRIGLILPAWTDLRVVYGHPFETVNASQSKALVERFFLGEMSSVEKAEFFHHYDVVYLFWSPGEDLMAQGKDLFEGDLVYQTGKVRVFRIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N614</accession>
    <name>E8N614_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560255.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18520"/>
    <dbReference type="EnsemblBacteria" id="BAJ63878">
        <property type="protein sequence ID" value="BAJ63878"/>
        <property type="gene ID" value="ANT_18520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18520"/>
    <dbReference type="eggNOG" id="COG0170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058561_6_0_0"/>
    <dbReference type="OMA" id="SWPIFST"/>
    <dbReference type="OrthoDB" id="1421771at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039606">
        <property type="entry name" value="Phytol/farnesol_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32523">
        <property type="entry name" value="PTHR32523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="233" mass="26018" checksum="EB2711D475ACDA02" modified="2011-04-05" version="1">MNEWMALGLTFGIALLWLRVNDYLAYRGWVSSSLSRKIIHLGTGPIFVLCWLFFPNTPLSKWLAALVPLLITLQFFLVGTGWIRDPQAVSAMSRTGDRREILRGPLYYGVVFVLLTLIFWKDSPIGVVALMILSGGDGLADIIGKRFPSSSLAWSPRKTVWGSLSVFVGGVFFSILVLSVFRLLGVFQFEWWDTFLKVVGIGIAATVVESLPFQDIDNLTVPLVSVFLGYFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N635</accession>
    <name>E8N635_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellobiose 2-epimerase</fullName>
            <shortName evidence="3">CE</shortName>
            <ecNumber evidence="3">5.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>D-cellobiose = beta-D-glucosyl-(1-&gt;4)-D-mannopyranose</text>
            <dbReference type="Rhea" id="RHEA:23384"/>
            <dbReference type="ChEBI" id="CHEBI:17057"/>
            <dbReference type="ChEBI" id="CHEBI:47931"/>
            <dbReference type="EC" id="5.1.3.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cellobiose 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.11" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="E8N635"/>
    <dbReference type="STRING" id="926569.ANT_18730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63899">
        <property type="protein sequence ID" value="BAJ63899"/>
        <property type="gene ID" value="ANT_18730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18730"/>
    <dbReference type="eggNOG" id="COG2942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046651_3_0_0"/>
    <dbReference type="OMA" id="WVQAETF"/>
    <dbReference type="OrthoDB" id="783590at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047736">
        <property type="term" value="F:cellobiose epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00929">
        <property type="entry name" value="Cellobiose_2_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028584">
        <property type="entry name" value="Cellobiose_2_epim"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="398" mass="46336" checksum="721C4676277D9E15" modified="2011-04-05" version="1">MEIRMLRTLADEMEKEVRERILPFWMGTARDPRGGVYGLVNEEGIPDPLASKGGTLQARVVWTFSRAYQLWPEQAYLDSAYHVWRFFLDHLWDNKHGGIYWLVDSRGYPLDSRKLTFANAYAIYAMSEYAKAFRDEEALKNAVFLFQQLDRIAHDEQGGGWLEGFDRDWKPVSDARISSNDMISDKSMNSHLHLLEAFVPLAQVWRDELLLLRLRECIDIFLNKILHPETHHFRLFFDRKWTPLSDWISFGHDIEGSWLLVKAAEVLGDTDLLAQVKEQAVQIVDCVLAEGLDEDGALVGEMNSAGQLEGQKDWWLQAETVVGCINAYQISGDLKYLQTATKTWNWIKENLRHPSGEWRWGTSREGQPQHRPLVDFWKCPYHNSRMCFEIISRNRQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N640</accession>
    <name>E8N640_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560281.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63904">
        <property type="protein sequence ID" value="BAJ63904"/>
        <property type="gene ID" value="ANT_18780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18780"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011926_0_0_0"/>
    <dbReference type="OMA" id="RTINDNM"/>
    <dbReference type="OrthoDB" id="398165at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="920"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="966"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111226" checksum="FF4CA0EBA9F3C273" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N670</accession>
    <name>E8N670_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">dnaA</name>
        <name evidence="13" type="ordered locus">ANT_19080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560310.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19080"/>
    <dbReference type="EnsemblBacteria" id="BAJ63934">
        <property type="protein sequence ID" value="BAJ63934"/>
        <property type="gene ID" value="ANT_19080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19080"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_1_0"/>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="141"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="12">
        <location>
            <begin position="349"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="447" mass="50292" checksum="BA141254C58F1BBE" modified="2011-04-05" version="1">MNPQQAWQATLGQLQMEMNKASFETWVKDAQLISVEGSDFIIGVPNAYARDWLESRLTATVQRILEGLMGATPAVKFIVWHRDEVDMPEEEVPEESHQQAFLRSGTSTINSRYTFDNFIVGASNRMAHAACMAVAESPAKAYNPLFLYGGVGLGKTHLLHAIGNAAQSRGLQVLYVSSEEFTNDLINAIRSHTTQAFRERYRNMDVLLIDDIQFIAGKESTQEEFFHTFNTLHGQDKQIVISSDRSPKALVTLEERLRSRFEWGLTVDIQPPDLETRIAILRSKAERNNKEVPYPILESIARLVQSNIRELEGALTRVLAFSDLSGMPLSPQLVHTALADMLPNRTHLDSSQVLEVVASEFGISLDELVGRSRSREVALPRQVAMYLMREEANASLPQIGEALGGRDHTTVMYACEKVADMIERDDRLRRKIFAIRERLYGRATVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N697</accession>
    <name>E8N697_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_19350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560334.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63961">
        <property type="protein sequence ID" value="BAJ63961"/>
        <property type="gene ID" value="ANT_19350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19350"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_380677_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="321"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="497"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="431"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="727" mass="80973" checksum="BBFD3DDE21468B0D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6E3</accession>
    <name>E8N6E3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560380.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19810"/>
    <dbReference type="EnsemblBacteria" id="BAJ64007">
        <property type="protein sequence ID" value="BAJ64007"/>
        <property type="gene ID" value="ANT_19810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19810"/>
    <dbReference type="eggNOG" id="COG5465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118111_0_0_0"/>
    <dbReference type="OMA" id="FDTYYPG"/>
    <dbReference type="OrthoDB" id="1892246at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="175" mass="19828" checksum="3D540CEB4FF8B141" modified="2011-04-05" version="1">MSYQGSGESSEDREISPNVLRAFETLHTFLEEDGWHPRRIEGRLSFTMGYTGENGDLRCFITIVPDVEELLFYAVAPVRVPEAVRPSVAEFITRANYGMRIGNFELDFADGEVRYKSSLNFMGEELTAGYIRNTIYPAVRTMDRYLLGLLRVSFGGVTPFEAIEEIERPADTPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6E5</accession>
    <name>E8N6E5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">moaA</name>
        <name evidence="14" type="ordered locus">ANT_19830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560382.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64009">
        <property type="protein sequence ID" value="BAJ64009"/>
        <property type="gene ID" value="ANT_19830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19830"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_0"/>
    <dbReference type="OMA" id="IEFMPIG"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="264"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ64009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="36493" checksum="2F947A7DB3E67211" modified="2011-04-05" version="1">MLTDSLGRTINYLRISVTDRCNLRCVYCMPPQGIPLTSHDAIMRYEEIVEVVRVAAEQGITDIRLTGGEPLARLGITELVHMIAAVPGIRDISMTTNGLLLERFAGELKEAGLKRVNISLDTLNPERFARITRGGSFEQVWRGILAAESAGLYPIKLNTVVMRGVNDDELLNLAKLTVEHEWHIRFIEMMPVNNQESWDEGFPSPQHIFVSLSEIKQRLESLNLKPVQGKSGSGPAREYQADGAKGKIGFISPISEHFCGECNRLRLTADGSLRPCLLSDLEIPVLPALRRGEPILPLLQEAVKLKPEGHHLSQNQRTFTRCMIQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXE3</accession>
    <name>E8MXE3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_19980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19980"/>
    <dbReference type="EnsemblBacteria" id="BAJ64024">
        <property type="protein sequence ID" value="BAJ64024"/>
        <property type="gene ID" value="ANT_19980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19980"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_4_0"/>
    <dbReference type="OMA" id="GLYTITM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="310"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="502" mass="56676" checksum="EF2BAC6A4F21EA1D" modified="2011-04-05" version="1">MASTTQKNGMVAPPKLQFRILHNISTPRQKYQWTGLKIALILLDAITISLGFLVAYLIRFELKLPIFYSMEESVSLHFYLSLGIILLPLWLGIFALHGLYSRPNLLGGTKEYSLLFNATTISMFLIITANFLIPEFILARGWLLLTWIFVFLFSFTARFLLRRLVYFLRKHGMFTSNAVIVGTNAEAQLLATQFKSADTSGLNVAGYIACPSSSSRAVPDENILGDLKEIEKIVYEKNVEEIIVTSSAVSAQEVVALFKLFGIAEGVNLRLSSGVYEIITTGLQVQEIASVPLVKVNKIRLTGWDQALKFLLDFGLSAILLPFIFPVGLVIALCIAMDSKGPVFHRRRVMGVNGHTFDAFKFRTMYVNGDAILDAYPELKEQLAREHKLKNDPRVTRVGRFLRKTSLDELPQILNVLKGEMSLVGPRMISPEEMEKYQEHGMNLLTVKPGITGLWQVSGRSDVSYDQRVQMDMYYIRNWSIWLDLQILFRTIPAVLSRKGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG4</accession>
    <name>E8MXG4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_20190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560415.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64045">
        <property type="protein sequence ID" value="BAJ64045"/>
        <property type="gene ID" value="ANT_20190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20190"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_3_0_0"/>
    <dbReference type="OrthoDB" id="1543624at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="41"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="287" mass="32718" checksum="9A73C7DB54C8A7CE" modified="2011-04-05" version="1">MVENSLSHPITHHHSPHVTVIEPSRGWSSLGLKDLWEYRELLWLLIWREVRGMYRQTALGVSWIFLRPILNVVILTLVFGTFVKVPSENVPYALFSLSALLPWGYFSNAVLRSAGSLVQNMEIISKVYFPRMIIAIAGVLSGLVDFSASFGIFLLFMAYFRVPVRIEILWLPGFFLASVLLALTVGLWLATLSVRFRDVSFAVNFLLQAMMYLSPVIYPVNQVPESLQFFYRLNPMAGIIEGFRWSLLGIGSPPQITFWLSMGLMLIFLVAGAFIFRRTERTIVDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH2</accession>
    <name>E8MXH2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560423.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20270"/>
    <dbReference type="EnsemblBacteria" id="BAJ64053">
        <property type="protein sequence ID" value="BAJ64053"/>
        <property type="gene ID" value="ANT_20270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20270"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_19_2_0"/>
    <dbReference type="OMA" id="FLNWYNV"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="37840" checksum="B9F8AFA60341E7D3" modified="2011-04-05" version="1">MTATAPNIPLPYFPFVSIVIPVYNGRKTIQTCLEAILQQEYPREQYEVIVVDNNSSDGTPDLVQKYPVKLVYEKEIQGPHAATNTGVKEAKGEILVFTDSDCVPEPDWLRRLIAPFSDDSVVGTGGRIEAYKPSTPVERFLDQMKPFKNAYQASPNFPAALITGNCAIRREDFMAAGMFNPNMYTGAEVDLSYRVQLQTGKRVIYVPEAVVYHIFSPTVKRLGRHFYIYGYSEILLGTIYKDVPGYPWTPTEQFKIMLRQVKALFTYLASFGFRVISYPFRRKVDQDYFLTPLFWFWVELNNLRGKIEGLWVTRLYRRKFWEKGVRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM5</accession>
    <name>E8MXM5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_20800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560476.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20800"/>
    <dbReference type="EnsemblBacteria" id="BAJ64106">
        <property type="protein sequence ID" value="BAJ64106"/>
        <property type="gene ID" value="ANT_20800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20800"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046644_0_0_0"/>
    <dbReference type="OMA" id="PVYEIFK"/>
    <dbReference type="OrthoDB" id="1601610at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="352" mass="39105" checksum="2A20B7FA1FB8AF1F" modified="2011-04-05" version="1">MELKPGKIALIGSGETSASGGKTFETVLRTLRASPKIAVLETPAGFELNSPQVAGKVGEYLAKRLQNFHPQIEVIPARKRGTEFSPDNPVILRPFFDADLIFFGPGSPTYTVRQLENSLAWEWIWARHLLGAALVVASAATIALGSLALPVYEIFKVGEDPHWKPGLHFFEPYGLNLVIIPHWNNNQGGDEVDTSHCFIGKPRFDLLMEHLPPHARVIGIDEHTSLIMDFQSREATVQGRSNVHVLGAHEEYTFENGEKFSLEILGNLQIPSSIETILSPTIWTQALAFQNTVTSPENAPSTIPREITTLVEEREKARLARNWEKADSLRKQILEMGYVIRDTPHGPEILPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU0</accession>
    <name>E8MXU0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560541.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21450"/>
    <dbReference type="EnsemblBacteria" id="BAJ64171">
        <property type="protein sequence ID" value="BAJ64171"/>
        <property type="gene ID" value="ANT_21450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21450"/>
    <dbReference type="HOGENOM" id="CLU_905024_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="32933" checksum="DCC9AB7266D3FA58" modified="2011-04-05" version="1">MTVYLPQILMAISLAAFAYYALEAVAKQRGRAAKTLADYYQPLTPQEERPIRTGSFEHKVRLAALQYRLNAAGRESLYYYGAMGALTLVFWAALVFLGVPAVLYLLAPVLGWVVVSGQVNGAWQKMRLALEKELPTFLLRMSATIQATPNVPEAIADVTASLDPAGPLQAWMKRLLAAIQTGGRRGLEEMQDEAAAISPSLMMAVMEIERLWETGGSGYVEAFRLASDNLASILEGRAMAAAKADGAWGTVRVILLALGGSLVVAMSSAAGGGLFDTPAVQIGLLLALAWAALGWNVIGDMIREVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY40</accession>
    <name>E8MY40_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smc</name>
        <name evidence="5" type="ordered locus">ANT_22450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560639.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22450"/>
    <dbReference type="EnsemblBacteria" id="BAJ64271">
        <property type="protein sequence ID" value="BAJ64271"/>
        <property type="gene ID" value="ANT_22450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22450"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_0"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="524"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="246"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="678"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="805"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1202" mass="137582" checksum="16A88CAC2681572B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY65</accession>
    <name>E8MY65_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_22700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560663.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64296">
        <property type="protein sequence ID" value="BAJ64296"/>
        <property type="gene ID" value="ANT_22700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22700"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="FSYLWFM"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="35"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="351"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="609" mass="68463" checksum="F00A3DE94098BB3D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD0</accession>
    <name>E8MYD0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558473.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62075">
        <property type="protein sequence ID" value="BAJ62075"/>
        <property type="gene ID" value="ANT_00410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00410"/>
    <dbReference type="HOGENOM" id="CLU_1393802_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="195" mass="20304" checksum="E25EF82A8C74BD05" modified="2011-04-05" version="1">MSDQNPFEDFDFGEETPSEPQPQEEKPSNRNFLIALGVIGGIFVLVAIALVAVVLFVLPQRNAALREQQQAQLAANTATAFAATENAQQALLLLTPSATPIPTATPVPPTNTPVIVQPPTATPTLTPTSVSDAQKATLSAQQTQLAAGKFTATVLPTSTALPETGFADQVGLPGMIGIGVALVVIILVARRLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD3</accession>
    <name>E8MYD3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558476.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00440"/>
    <dbReference type="REBASE" id="32145">
        <property type="entry name" value="AthUNI1ORF430P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62078">
        <property type="protein sequence ID" value="BAJ62078"/>
        <property type="gene ID" value="ANT_00440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00440"/>
    <dbReference type="eggNOG" id="ENOG502ZA78">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730772_0_0_0"/>
    <dbReference type="OMA" id="SWWVSPK"/>
    <dbReference type="OrthoDB" id="813533at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="354" mass="40965" checksum="71E525563AF84AA1" modified="2011-04-05" version="1">MHIHATIEGIQYQPFFGRKLNEYDISHLQEALQTDASFLLRFPDSSQVAVSVWVSPKRTRSYPFARVYDTYGFQGKKITLIPVYKDEGFDGERDYLQWDTVSLMSLLGVYVILGFYSHAEKNPHYPNKITRQQMDINFLLEQFHAVMNYRSDALHWNLVQTERLAEIGRLACESYRVISERTGVKMHSFEAVEKRLAVFSAGREKFISFSRRMAQEAQEREFRTVQPKENLKGKKAKITILNYLGGEYHFTCDEVEIHENSLLLMEGKHSRDASLPSLSDIKDGLLKMILYTNLKDVSLNGMKYIPQPVLKLTTGELLHETPQIVETLNILLREARANGFWVMLNENLIGSDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE9</accession>
    <name>E8MYE9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmI</name>
        <name evidence="5" type="ordered locus">ANT_00600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558492.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62094">
        <property type="protein sequence ID" value="BAJ62094"/>
        <property type="gene ID" value="ANT_00600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00600"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_4_1_0"/>
    <dbReference type="OrthoDB" id="2018410at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="78" mass="8959" checksum="F9A82F2FCE8803AD" modified="2011-04-05" version="1">MPRKVKPGKFKLKTHKATSKRFRLTGSGVLVRTKGGKSHLRRRTSKRTKALFTEMLPVQGEGIIKRVERLAPYLKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI0</accession>
    <name>E8MYI0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558523.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00910"/>
    <dbReference type="EnsemblBacteria" id="BAJ62125">
        <property type="protein sequence ID" value="BAJ62125"/>
        <property type="gene ID" value="ANT_00910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00910"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_8_0_0"/>
    <dbReference type="OMA" id="FPGGESM"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="23756" checksum="197633E51CC9E5BD" modified="2011-04-05" version="1">MKTPTILLLIRHGETNFVVQGRLPGRLPGVVLTEKGIQQARALSERLAEAPIRAVYASPLERARETARPLAEAKGLPILTAEGLNEVDPGGWAGRTLKSLRRLKAWKALREDPGRFAFPGGESFPEAQVRIVAQIEELRRRHPGEMIACFTHADVVRLAVAHYLLMPLQALHRLAAAPASLSVVVFGEDGEVQVPHVNQVDGLALTPPPEKKPHGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ8</accession>
    <name>E8MYJ8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_23080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23080"/>
    <dbReference type="EnsemblBacteria" id="BAJ64334">
        <property type="protein sequence ID" value="BAJ64334"/>
        <property type="gene ID" value="ANT_23080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23080"/>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039914_2_0_0"/>
    <dbReference type="OMA" id="IPMYICA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="352" mass="37775" checksum="CB0EA91689F97583" modified="2011-04-05" version="1">MNMFRSISKNVSPRLLRWIPWGVTGFLLFAALLRFSEAALGSLPVILTKALDTLSNFSAVFLGIFVEAVPFLLLGTLASGIVEVFVSRDELMRWVPQQGIGSALAGSLMGLFFPVCECGVVPFTRRLVRKGLPLSAGISLLLAAPVVNPIVIASTLAAFGAGPVFWGRIIASLLIAFLTGLVFTLAQPQEVLRSAPVIALPPVILPLESPAQTPLSQRIRQVLILAADEFFEMGRFLVLGALLAAFMQTFIPQAGLLVLGQGPVLSVFVMIALAILLSVCSTVDAFIALAFTGTFTTGSILAFLVFGPMVDIKSTLMFLRVFKPRAVLYLILLPLLMTALWMVGVNLWGGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM9</accession>
    <name>E8MYM9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_23390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560731.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23390"/>
    <dbReference type="EnsemblBacteria" id="BAJ64365">
        <property type="protein sequence ID" value="BAJ64365"/>
        <property type="gene ID" value="ANT_23390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23390"/>
    <dbReference type="HOGENOM" id="CLU_1515167_0_0_0"/>
    <dbReference type="OrthoDB" id="2128884at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="20419" checksum="CB6024C812417ABB" modified="2011-04-05" version="1">MVSLNALFWLFVILFAIIGAMRGWAKELLVTFSAILAFFIVTVLETYVPFVKDTLRNNPDTLFWLRIIVLILAVFFGYQSPNIQKFAAGGRFAREKLQDYLLGFLLGAINAYLFVGTIWWYMDQAGYKPLLPYITPPDPNTEVGRAALDLLEQMPPVWLKPPGLFFAVALAFAFVLIVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN2</accession>
    <name>E8MYN2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">murB</name>
        <name evidence="18" type="ordered locus">ANT_23420</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64368">
        <property type="protein sequence ID" value="BAJ64368"/>
        <property type="gene ID" value="ANT_23420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23420"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_0"/>
    <dbReference type="OMA" id="MQNIGAY"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="32"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAJ64368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="33215" checksum="9C2A52BF04382646" modified="2011-04-05" version="1">MTFALPMNRLREAFGDALQENVPLAAYTTARVGGPADAFLPVHDLAQLERAVRLLWDLNVPYLILGSGSNLLVSDAGYRGVVIFNRARNVKIDVHHQPPSVWAESGANLSHVARQTALRGLSGLEWAATVPGTVGGAVYGNAGAFGGDMAGNLALAEILHPELGKVHWSAEEMGYGYRTSILKREKSKAVILAARMNLTQSTVEEVQARIETFSAKRRATQPPGATMGSMFKNPPGDYAGRLIEAAGLKGKRIGKAEISPVHANFFVNLGGATAADILQLIQIAQKTVQDKFGVTLELEIECIGEWENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP4</accession>
    <name>E8MYP4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560746.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64380">
        <property type="protein sequence ID" value="BAJ64380"/>
        <property type="gene ID" value="ANT_23540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23540"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951885_0_0_0"/>
    <dbReference type="OMA" id="WEVGNAY"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="251" mass="27499" checksum="15D4E5A0BA4062DA" modified="2011-04-05" version="1">MGLADLHIHTIYSYDGTCSVPAVLKHVKTQTLLDVIAITDHDSIRGALEALDRASAYHLEVIPGCEVSTRDGHVLALFIEKPIPPHLSLKETVLRVGEQGGICIAAHPTAPGTSSLDFKTIQEALQDPDVRRILVGVEAFNGGLVYTRQNPMVEKQAQSLPLAMVGNSDAHILRMIGQGATHFPGNTAQELRHALETRSTAVFKGNGLSGLNVMRDYLPHFFLRKIGWVTHNPHPQAPLRFERLSRVMTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYR8</accession>
    <name>E8MYR8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_23780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560770.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23780"/>
    <dbReference type="EnsemblBacteria" id="BAJ64404">
        <property type="protein sequence ID" value="BAJ64404"/>
        <property type="gene ID" value="ANT_23780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23780"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_575757_0_0_0"/>
    <dbReference type="OMA" id="FATENFA"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225160" evidence="3">
        <location>
            <begin position="27"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="280"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="4">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="352"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="474" mass="50771" checksum="C0710CED2BD8E2BE" modified="2011-04-05" version="1">MKTWTRWILFISLLAILLSSVSPAQAEDEVKLNAPSSEVTAYDLILAMNTLRVSNGLSPLIEDPIINAVAQSTAEIMAANQMSWHIGNVSGRLQSAGYGGGAKVFATENFAVGSTFTIDEIMLAWADPDHMIPAVNPAYCHVGAGVARAANGMTYYVLQAAYVAGKSCGEYRPPANYTPKPGETPVNPGVPQIIVPVKVATPDADGKIFHVVQSGQSLWAIAVAYKVTIKDLEIWNNLSRNVPLQVGQKLFIPSSNTAGYATPTPAWMIQKATPDADGRIVHEVKAYQTLIRIAEAYGTTVDALLAYNGIQADWPLQIGQKLIIYPGNITPSPTPRPLTPIEKLTPAADGKYYHTVQSGETLAWIAKLYEVSLNDLMAWNGLNAMSIIHPGDRILLQVTPPVTPTFTPSPTLPPTATPVPPTATPSPTPTVVEVTPTPEGTESGMSSAPWLWVFLALAVAGGVLVWVFSKKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYV6</accession>
    <name>E8MYV6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64442">
        <property type="protein sequence ID" value="BAJ64442"/>
        <property type="gene ID" value="ANT_24160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24160"/>
    <dbReference type="HOGENOM" id="CLU_3179508_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="47" mass="5398" checksum="5436CE929CF35906" modified="2011-04-05" version="1">MSDWRTDKQTTFETLTLSTACFIWVVLTLLLSVAYVVWVVFNAGGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX6</accession>
    <name>E8MYX6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24360"/>
    <dbReference type="EnsemblBacteria" id="BAJ64462">
        <property type="protein sequence ID" value="BAJ64462"/>
        <property type="gene ID" value="ANT_24360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24360"/>
    <dbReference type="HOGENOM" id="CLU_2840124_0_0_0"/>
    <dbReference type="OrthoDB" id="2225026at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="65" mass="7178" checksum="844142547E45C800" modified="2011-04-05" version="1">MFEARLKVHPTRARVSTKAAPEVVQALKAAGLEVEVAEGQIPWDVWLTDGRRAEEQMSLFEEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ50</accession>
    <name>E8MZ50_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidyl-prolyl cis-trans isomerase B</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppiB</name>
        <name evidence="3" type="ordered locus">ANT_01590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62193">
        <property type="protein sequence ID" value="BAJ62193"/>
        <property type="gene ID" value="ANT_01590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01590"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649951_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225340" evidence="1">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="267"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="422" mass="46654" checksum="904892B8A0F28172" modified="2011-04-05" version="1">MKLRWQWMMLALCLSSLGMLAGGCSPAPAPLSPQPSPSATLALNIPKTTPLPETMDCVLVSVEPTPTPSTEPPLFPPPSAQDWTQGPENAVLTFIEYTDLQAPASLALDWSLTRLRERYPEKVRRVFRHFPLPANDKSLLAGAAAEAAGAQGKFWEMTHLLLERQEEWTPLPEAEFRAWLEARAADLALDVPTFLSALDDPAIRLSLQQAQEEGFRLGIPTMPFVLVNQRMYQGPRDYRSLETLLLLEDLKSRQFRQCPPFVIDPARTYVAVLETTQGELRIQLFADQAPQTVNNFVFLARQGWYDGVLFHRVLPGYIAQSGDPSGSGFGTPGYAFADELNALRFDQPGRVAMANAGPNSNGSQFFIAYTALPDLDGQYPIFGQVIEGLEVLNRLTPRDPSSPADLPEGDRILRVRILEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE9</accession>
    <name>E8MZE9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidored_molyb domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560852.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64497">
        <property type="protein sequence ID" value="BAJ64497"/>
        <property type="gene ID" value="ANT_24710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24710"/>
    <dbReference type="eggNOG" id="COG2041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094953_0_0_0"/>
    <dbReference type="OMA" id="VVPHLYA"/>
    <dbReference type="OrthoDB" id="1729032at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="1">
        <location>
            <begin position="37"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="212" mass="24844" checksum="67F2825D7304D0FE" modified="2011-04-05" version="1">MFDQIRKRKQEEEAMRAAGRLPPGQALTQKFPVLHYGPVPTFNPETWDFRVWGEVEQPLRLTWEEFNQLPKTRVTMDLHCVTKWSKFDTVWEGVSVRTLIELGLVRLKPTARFVMQHAEYGFTANLPLEVVLQENFLLATHYDGKPLDPEHGYPLRGVIGFIPDRPDLKTPYLWKGAKWLRGLEFMAQDRPGFWEMAGYHNDADVWKEERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH0</accession>
    <name>E8MZH0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl xylan esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_24920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560873.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24920"/>
    <dbReference type="ESTHER" id="anatu-e8mzh0">
        <property type="family name" value="Acetyl-esterase_deacetylase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64518">
        <property type="protein sequence ID" value="BAJ64518"/>
        <property type="gene ID" value="ANT_24920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24920"/>
    <dbReference type="eggNOG" id="COG3458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054209_1_0_0"/>
    <dbReference type="OMA" id="VHFAARG"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="36152" checksum="A685DDCACD166351" modified="2011-04-05" version="1">MAFFDLPIEELQTYLPSRGEPEDFDAFWQATLSEARQYPLNARFERVEVGLKTLEAFDVSFSGYGGQTIKGWLLLPVNRQGKLPCVVEYIGYGGGRGSPLNWLLWPSCGYATLVMDTRGQGSSWQPGDTPDPEPEGANPHYPGFMTRGILSPYTYYYRRVFTDAVRAVETAQAHPAVDAERIAITGGSQGGGITLAVAGLCPQVRVAMPDVPFLCHFRRATQLVDTHPYAEIASYCKTHRDKVERVFQTLSYFDGMNFAARARAAALFSVGLMDTICPPSTVYAAYNHYAGFKQMRVYEFNNHEGGGTYQSEAKLAFLHEHLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM1</accession>
    <name>E8MZM1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25430"/>
    <dbReference type="EnsemblBacteria" id="BAJ64569">
        <property type="protein sequence ID" value="BAJ64569"/>
        <property type="gene ID" value="ANT_25430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25430"/>
    <dbReference type="eggNOG" id="COG2335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369076_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="78"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="213"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="348"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="483"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="618"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="754" mass="79567" checksum="3D5D09FB9FF97573" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP9</accession>
    <name>E8MZP9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">natB</name>
        <name evidence="2" type="ordered locus">ANT_25710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560952.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64597">
        <property type="protein sequence ID" value="BAJ64597"/>
        <property type="gene ID" value="ANT_25710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25710"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022118_2_0_0"/>
    <dbReference type="OMA" id="KDAFRDR"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="392" mass="43533" checksum="856500ADAD3E18D2" modified="2011-04-05" version="1">MKLIWIVFRKEWIDHLRDQRSVVSALANSLFTPVFMLAMILLVGKTMMSMSEEKPEPLHVLGQQYAPAFMQYLEANNIEIIPADENLVEEVRQGKVKMGLIIPEEYAQAFREGRPAPVELVMDTSRQTNLMVMSKVTQLIQAYSKEVTSLRLMARGVDPLIQLPIVPNVRDVATPQSSALLFMSMLPFFTAIVVFSAGAGIIVDSLVGERERSTLEPLLINPVRRSYLLIGKVLTSFFFAVIVVGLSLFIFWLGFQVLPIEDAFGFSMTLSAASLFWIFLLTIPETALAAVLQAFIASFARTYKEAQTFLAILPFVIGIPSVVLAFVPNPSDLTQIAIPGFGHSVLFNRLLRGEPVTPLEVVVLLLVTLVSTGIILFLAIRSFGRERILSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR8</accession>
    <name>E8MZR8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560971.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64616">
        <property type="protein sequence ID" value="BAJ64616"/>
        <property type="gene ID" value="ANT_25900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25900"/>
    <dbReference type="eggNOG" id="ENOG5033SRX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821216_0_0_0"/>
    <dbReference type="OrthoDB" id="1698421at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="361" mass="41350" checksum="538F6180D5818C20" modified="2011-04-05" version="1">MLEIKTSSFHYPFVFLEEDSSTVEVELELEKPLPCSSHPQESGFYRPGQIHFQNGHHPLELVLYHNLATAQFIYLHEQPADAHFLRIAGLKEKEIPNSLPITLPGQLCLGAARTALIGKAMQGLFSAPPLREILQQYTQEQIAIFPIAREGLKYQIAEALFDTQGYYCDEIILDAHHVFDHTVPLYNRKVEMTLFKDKDLEPAQRNGVKVAIIGDSIASGLVMREVIEHIRRRFPALERVEVIAPLATVRGLTRLARTSFNGTIPVRAHVFETLLNALPPDYYYSAHFNIPELHIRPDMEQTYRQWWGMDATGQWIADTACAGYGWSEVFYSPRKQIQMINEELHRRHGLTLAEILRRNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU7</accession>
    <name>E8MZU7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">infC</name>
        <name evidence="9" type="ordered locus">ANT_02480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558679.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62282">
        <property type="protein sequence ID" value="BAJ62282"/>
        <property type="gene ID" value="ANT_02480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02480"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_0"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="OrthoDB" id="1760144at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="8">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="7">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="215" mass="24315" checksum="CF8C608A4006C5D5" modified="2011-04-05" version="1">MFKRVIYIYLLKDGEKPISTQTFRVNEMIRVPEVRLIGPGGENLGVVPIQEALRIARDAELDLVEVAPGATPPVCRVMDFGKFLYERAKKEREAKKAQTRIEVKEIRLRPKTNEHHRGFKTRDARRWLLEGNKVKVTVRFRGREITYPELALEDLREIAEELSDIATIEQAPVLEGKVMTMVLSPAKPGKKKGESQPKAASSTSETPAAEPQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW8</accession>
    <name>E8MZW8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative isobutyryl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_02690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558700.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02690"/>
    <dbReference type="EnsemblBacteria" id="BAJ62303">
        <property type="protein sequence ID" value="BAJ62303"/>
        <property type="gene ID" value="ANT_02690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02690"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_0"/>
    <dbReference type="OMA" id="IAQKEWV"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="2">
        <location>
            <begin position="30"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="549" mass="61962" checksum="A0557B4F5FD651AF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX2</accession>
    <name>E8MZX2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558704.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02730"/>
    <dbReference type="EnsemblBacteria" id="BAJ62307">
        <property type="protein sequence ID" value="BAJ62307"/>
        <property type="gene ID" value="ANT_02730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02730"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_9_3_0"/>
    <dbReference type="OMA" id="IFTTPTC"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011911">
        <property type="entry name" value="GlrX_YruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02196">
        <property type="entry name" value="GlrX_YruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="86" mass="9516" checksum="733CD4A196F3BA7A" modified="2011-04-05" version="1">MPEAGKTFPKVIIFTTPTCTYCNAAKRYLRERGVPFKDVDVSRDAAAARDMVRRSGQSGVPVLDIGGKIVVGFDRPKIDQYLGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N041</accession>
    <name>E8N041_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558773.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62376">
        <property type="protein sequence ID" value="BAJ62376"/>
        <property type="gene ID" value="ANT_03420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03420"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327804_0_0_0"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="324"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="488"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="877" mass="96787" checksum="65F2FE9CC78B7ABA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N046</accession>
    <name>E8N046_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558778.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03470"/>
    <dbReference type="EnsemblBacteria" id="BAJ62381">
        <property type="protein sequence ID" value="BAJ62381"/>
        <property type="gene ID" value="ANT_03470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03470"/>
    <dbReference type="HOGENOM" id="CLU_2217077_0_0_0"/>
    <dbReference type="OrthoDB" id="2094049at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="113" mass="12574" checksum="5EE457EBD434C85D" modified="2011-04-05" version="1">MVVTGWNNGAHSRHGAGYGFRVQTADRDAFFQKDWTSIQVELEGEEGTVDIALPGEAFWSENGAPLVSPAVGRWLRKNGLAPWARGNPPTFILDPIEGNRFRVRKAPRQRPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N048</accession>
    <name>E8N048_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cdsA</name>
        <name evidence="9" type="ordered locus">ANT_03490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558780.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03490"/>
    <dbReference type="EnsemblBacteria" id="BAJ62383">
        <property type="protein sequence ID" value="BAJ62383"/>
        <property type="gene ID" value="ANT_03490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03490"/>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_3_3_0"/>
    <dbReference type="OMA" id="FTFDEVG"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="29540" checksum="9EA8D25B6699E280" modified="2011-04-05" version="1">MLASLSPLSQRLLVALLLIPIGIALIWVGGAPFALFVALVLGLAALEYAHLFEHGGFHPTTWILAGGSALLPLIRLWGGDAFALPALTALIFLTMGWQVFTYRHTHETAVLDLNITLGGLVYLGGLGGYLVSLRQLPDGMWWFLLVLPAIWFADAGAYFVGSRWGRHKMAPHISPSKTWEGYLGGVVSAILLTAGLAALWNLRIPYLTPAHGALLGAVIAVLSPLGDLGESLLKRGFGVKDSSHLLPGHGGVLDRIDSWLWAAPLGYYMIVWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N058</accession>
    <name>E8N058_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, family 51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_03590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62393">
        <property type="protein sequence ID" value="BAJ62393"/>
        <property type="gene ID" value="ANT_03590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03590"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_0"/>
    <dbReference type="OMA" id="IARVEWW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="2">
        <location>
            <begin position="150"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="953" mass="104722" checksum="240985514ADD37D4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N097</accession>
    <name>E8N097_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_26200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64646">
        <property type="protein sequence ID" value="BAJ64646"/>
        <property type="gene ID" value="ANT_26200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26200"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_1_0"/>
    <dbReference type="OMA" id="YANNIPP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="365"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="618" mass="70717" checksum="03F955BF6BE24FBE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0A6</accession>
    <name>E8N0A6_ANATU</name>
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        <submittedName>
            <fullName evidence="6">Putative glycosyl hydrolase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <text evidence="1 4">Belongs to the glycosyl hydrolase 35 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26290"/>
    <dbReference type="EnsemblBacteria" id="BAJ64655">
        <property type="protein sequence ID" value="BAJ64655"/>
        <property type="gene ID" value="ANT_26290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26290"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395770_0_0_0"/>
    <dbReference type="OMA" id="WMINEYV"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="5">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="768" mass="87266" checksum="28AA8E43EE9AEE01" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B2</accession>
    <name>E8N0B2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561015.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26350"/>
    <dbReference type="EnsemblBacteria" id="BAJ64661">
        <property type="protein sequence ID" value="BAJ64661"/>
        <property type="gene ID" value="ANT_26350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26350"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014011_0_0_0"/>
    <dbReference type="OMA" id="TWTARNE"/>
    <dbReference type="OrthoDB" id="54422at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043751">
        <property type="entry name" value="DUF5696"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18952">
        <property type="entry name" value="DUF5696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="747" mass="83982" checksum="D659090F4C783AE7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0C0</accession>
    <name>E8N0C0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_26430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561023.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26430"/>
    <dbReference type="EnsemblBacteria" id="BAJ64669">
        <property type="protein sequence ID" value="BAJ64669"/>
        <property type="gene ID" value="ANT_26430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26430"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_0_0_0"/>
    <dbReference type="OMA" id="PQSFHWT"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="778"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="301"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="496"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="761"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="861" mass="93727" checksum="025480576E91DAA4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0D3</accession>
    <name>E8N0D3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64682">
        <property type="protein sequence ID" value="BAJ64682"/>
        <property type="gene ID" value="ANT_26560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26560"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="EMGSDDY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="235" mass="26535" checksum="30CDFE99E4B7E734" modified="2011-04-05" version="1">MLMNEGRKLSPAKILLIDDEISIHTVVTAYLKAEGYEYQSAMDGPSGLAMARSFKPDIIILDVMLPGMDGIELLAHLRRESNVYVIMLTARSEETDKIVGLSVGADDYLTKPFSPRELMARIKAALRRLNPPPAATSETAMLNFAHVRIDPSARRVWVNNTLIDLTTVEFDLLLTLAQHHGRVLSREQLLEKVWGYDYYGDTRVVDVHIGHIRQKLGNNTWIETVRGVGYRFEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L1</accession>
    <name>E8N0L1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04850</name>
        <name evidence="3" type="ordered locus">ANT_27340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="3">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558915.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04850"/>
    <dbReference type="EnsemblBacteria" id="BAJ62519">
        <property type="protein sequence ID" value="BAJ62519"/>
        <property type="gene ID" value="ANT_04850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64760">
        <property type="protein sequence ID" value="BAJ64760"/>
        <property type="gene ID" value="ANT_27340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04850"/>
    <dbReference type="KEGG" id="atm:ANT_27340"/>
    <dbReference type="HOGENOM" id="CLU_2535285_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="83" mass="9016" checksum="E7FA884FE1D0787B" modified="2011-04-05" version="1">MLILRMFLVGWIVLAGAILLNLLAGALHLATWYTFLQSVSAQGLTSALRALRWQDAVFLFLVYPLGLGGLAWAGGWLARQMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y8</accession>
    <name>E8N0Y8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04990</name>
        <name evidence="2" type="ordered locus">ANT_19270</name>
        <name evidence="3" type="ordered locus">ANT_19850</name>
        <name evidence="4" type="ordered locus">ANT_30020</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="1">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04990"/>
    <dbReference type="EnsemblBacteria" id="BAJ62533">
        <property type="protein sequence ID" value="BAJ62533"/>
        <property type="gene ID" value="ANT_04990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63953">
        <property type="protein sequence ID" value="BAJ63953"/>
        <property type="gene ID" value="ANT_19270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64011">
        <property type="protein sequence ID" value="BAJ64011"/>
        <property type="gene ID" value="ANT_19850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65028">
        <property type="protein sequence ID" value="BAJ65028"/>
        <property type="gene ID" value="ANT_30020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04990"/>
    <dbReference type="KEGG" id="atm:ANT_19270"/>
    <dbReference type="KEGG" id="atm:ANT_19850"/>
    <dbReference type="KEGG" id="atm:ANT_30020"/>
    <dbReference type="eggNOG" id="COG1662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079844_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="13915" checksum="38C37BC2C25B3193" modified="2011-04-05" version="1">MVWERTDSAIQEMVDEAPKAKQYFSDAFDAYNRLWYHGGRYAVSEGKRETYSVEGDNAELRHYLARLARSSRCFSRCRFALECALRLFAYCFNSRQLYRQRYPAYPAHVMEFIPPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N124</accession>
    <name>E8N124_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05350"/>
    <dbReference type="EnsemblBacteria" id="BAJ62569">
        <property type="protein sequence ID" value="BAJ62569"/>
        <property type="gene ID" value="ANT_05350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05350"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096864_0_0_0"/>
    <dbReference type="OMA" id="CFGFMHH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016300">
        <property type="term" value="F:tRNA (uracil) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032873">
        <property type="entry name" value="Trm9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="PTHR13069:SF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="28748" checksum="F98C554FBCC6C890" modified="2011-04-05" version="1">MPPGMDTKAIEVLREINRTFYLQYGESFARTRRRVQNGVKQVLERLPDEGVWLDIGCGSGALAVEWLQRGRKSRYIGMDFSEVLLEEARRAVSALHAGEQVTFLHGDLTAPNWHLAVQDIPLQGILAFAVLHHIPSHDLRLALLRTVHSLLPPGGWFVHSEWQFHHSPKLMSRRLPWSVVGVNEENLEAGDTLLDWRETLPAGEEQGGLRYVHLFSPEELQQLAEQAGFSIEETFSSDGLGNRLSLYQIWKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N141</accession>
    <name>E8N141_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative succinate dehydrogenase cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhC</name>
        <name evidence="8" type="ordered locus">ANT_27580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561132.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64784">
        <property type="protein sequence ID" value="BAJ64784"/>
        <property type="gene ID" value="ANT_27580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27580"/>
    <dbReference type="eggNOG" id="COG2009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127125_2_1_0"/>
    <dbReference type="OMA" id="WSWVAHR"/>
    <dbReference type="OrthoDB" id="2046680at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="130" mass="14276" checksum="0E52D8EE8419B8C3" modified="2011-04-05" version="1">MNEPKKLHSRGVLDWFDPRGRQVGGWGFIINRISAIGLTVYLYLHLVMLGKLAQGPESFDAFIATAKQPLILFGELLVIIAGLYHGLNGIRIALTSFGVAVRYQRALLIGVVLLTAAGSLFFAIRMLSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N168</accession>
    <name>E8N168_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561158.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27850"/>
    <dbReference type="EnsemblBacteria" id="BAJ64811">
        <property type="protein sequence ID" value="BAJ64811"/>
        <property type="gene ID" value="ANT_27850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27850"/>
    <dbReference type="eggNOG" id="COG3428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111557_1_0_0"/>
    <dbReference type="OrthoDB" id="1750498at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="75"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="169" mass="19124" checksum="E8C72614AE621F3D" modified="2011-04-05" version="1">MSYISDNLLPNEKVFFTARVHPMIFLSPVLAFIVTVFLFILSLNEKDASVLICLFLFLLFYSILLGIRATIMMLTTEFGVTNRRIIAKSGFIRRQTIEIFLSKIESVSVYQSILGRIFNYGTVTVIGTGGTKGSFQGIANPIETRKKIYQMIEIYTQSQQEAKEKSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N194</accession>
    <name>E8N194_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561183.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28110"/>
    <dbReference type="EnsemblBacteria" id="BAJ64837">
        <property type="protein sequence ID" value="BAJ64837"/>
        <property type="gene ID" value="ANT_28110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28110"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_1_1_0"/>
    <dbReference type="OMA" id="TYQYQCT"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="88" mass="9620" checksum="2944EBD591DEBE43" modified="2011-04-05" version="1">MPVYTYRCESCGLQFDHTQKFSDPPLTECPECGEPVRKVYQPVGIVFKGSGFYATDHRSPSGNGKSRSESKSTEKSASDSSSSSESKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A1</accession>
    <name>E8N1A1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561190.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28180"/>
    <dbReference type="EnsemblBacteria" id="BAJ64844">
        <property type="protein sequence ID" value="BAJ64844"/>
        <property type="gene ID" value="ANT_28180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28180"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070266_0_0_0"/>
    <dbReference type="OMA" id="THFDHAM"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="276" mass="30321" checksum="78635980529FE153" modified="2011-04-05" version="1">MAPASLQVIFLGTTTLYLSDGETHLLTNGFFTRPPLTQMLFGRLAPSRERIGQALQRAGIQQVDALLVGHSHYDHALDCAEVCRQTGAVLAGSVSTLNIGRGAGLPEERLYLANAGSIFSWGKFRVTFLPWKHSFPRFYPGEIVTPLVPPVPVSAYREGGTFALFIEHPAGSLLILESAGILPGALKGIRTRAVLLAVAGFPRLPAGRERLFREAVLNTGAQRVFPIHHDHFFLPLDNPPVLLPGSRAVMDWLERRCRQEGIGFEVLPPWERTALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1B5</accession>
    <name>E8N1B5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative pyruvate:ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">ANT_28320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561204.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28320"/>
    <dbReference type="EnsemblBacteria" id="BAJ64858">
        <property type="protein sequence ID" value="BAJ64858"/>
        <property type="gene ID" value="ANT_28320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28320"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_0_0_0"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="182" mass="21192" checksum="54D93373712B76A4" modified="2011-04-05" version="1">MYLFLTYLCNRATKDFYDIVGVRVYGEILGWVRKRIKDPFTLVGLIDGEWVGFANGRVMNPDIAISLHTMTFTRRGRVGWAMYYAKTYYALEILKCKEWWSTFESYNGWRMAGVEMAQPTKPWPEYQHELGGARVYYLTQDMWNAGVKNFAVEMIGSDLSFNVTDEVRKANEHFHAPAEVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S1</accession>
    <name>E8N1S1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559071.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62676">
        <property type="protein sequence ID" value="BAJ62676"/>
        <property type="gene ID" value="ANT_06420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06420"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_1_0"/>
    <dbReference type="OMA" id="QYLPDWR"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="129"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="323" mass="35799" checksum="2934576D654A086A" modified="2011-04-05" version="1">MKFLIAGFGSIGRRHLRNLRALGEEDILLLRSHRSTLPDDEIAGLPVETDIHAALAHRPDAVIIANPTALHLQVAIPAAEQGCSILMEKPIADSTEDIPALRRALEKGGGQLLVGFQFRFHPTLQQAAKLLSEGVIGRVVSVRSHWGEYLPNWHPWEDYRQSYAARPDLGGGVILTLCHPFDYLRWLLGEYAIGWAGGGTLGDLELQVEDCAEIGLKFRNGAVGTLHLDYLQQPPRHTLEVIGTAGTLQWDNADATLRVFRAGESDWQVFSAPEGFERNWMFLEEMRHFLAVARREVQPACTLEDGVRALQLALAAREALKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z9</accession>
    <name>E8N1Z9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561290.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64946">
        <property type="protein sequence ID" value="BAJ64946"/>
        <property type="gene ID" value="ANT_29200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29200"/>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432068_0_0_0"/>
    <dbReference type="OMA" id="FAHEWQH"/>
    <dbReference type="OrthoDB" id="119428at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M6" evidence="1">
        <location>
            <begin position="461"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="681" mass="75529" checksum="EDEF7881F53499EB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N203</accession>
    <name>E8N203_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561294.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64950">
        <property type="protein sequence ID" value="BAJ64950"/>
        <property type="gene ID" value="ANT_29240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29240"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_36_4_0"/>
    <dbReference type="OMA" id="IHACDFD"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="213"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="377" mass="43504" checksum="A30578A5DF9DB63B" modified="2011-04-05" version="1">MPEKKVLFCRSNPIAPDPRVEKEARALTRSGYSVDVLAWDRTASQPRVEQREGFFIYRIPIRAGYAAGILNLPNLLRWQVALVGWLFRHAHEYDILHACDFDTILPALWTGRLYGKRVVYDIFDFYADHLRRTPGWIKNWIRRRDLRAIDQADAVILCDDARREQIAGSHPRRLEVIYNSPEDERDFLPAFQPSPKGVLRLSYVGLMHVERMLLEMLDVLSRHPQWTLDMAGFGGDEPVILEKLRTLPNALWHGRVPYRKALELSQSADVLFALYDPAVINNRYSSPNKLFEAMMLGKPIVVAQGTNVDRIVEEWGMGIAIPYGDVDALDEALSRLAEDPDLRERMGKAARRAYETRFGWKVMEQRLMDLYRELNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N229</accession>
    <name>E8N229_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_29500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561320.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64976">
        <property type="protein sequence ID" value="BAJ64976"/>
        <property type="gene ID" value="ANT_29500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29500"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="RIAINQC"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="203" mass="23624" checksum="7C8B44BE4E1DBDFC" modified="2011-04-05" version="1">MDELALIQEARNGDLNAFNRLVLAYQDMAYHLAMRMLSDPDQAEDVTQTAFLSAYRHLSSFRGGSFKAWVMRMVTNACYDELRRRQRHPSTPLEPLDDDDETIESPSWLADDGLSPEEQLEQKELDRAIQRCLQQLDEEFRAVVVFIDLQGMDYQEVAEILGKPLGTVKSRLARARLKLRDCLHRFWELLPPLLRLTSQRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N285</accession>
    <name>E8N285_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561373.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65032">
        <property type="protein sequence ID" value="BAJ65032"/>
        <property type="gene ID" value="ANT_30060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30060"/>
    <dbReference type="HOGENOM" id="CLU_603628_0_0_0"/>
    <dbReference type="OrthoDB" id="2147255at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="453" mass="49160" checksum="9B593FBA2511E9E9" modified="2011-04-05" version="1">MLSIRKSALVMLILTLIGSSLLALGSHQPQTVQAEPLQPALATPRVHITALAPTPVSLQSAPPAPQEVAQNQPAAVKPQSEAQTAPQSQNVQPQAAPPDDAAAVLLRNAAVLQEVVARRAQDPSTAFIYKFMQNYQTRGDGGGCAAVWEMVPDYASLPNWLTTPSRPEQLYSKISLYFLAAMLIKNKAVDASACENGGLSTKNEWVANNCGLSLAYAAVVQWQNRFNEVILNVAQETGVPAQLIKNIFSRESQFWPGIYFLIQEAGLGQLTPAGADTLLLWNPFFYEQFCPQVLLPEVCRKGYTNLTWEEQELLRGALMRMVDASCPLCPGGIDPYQSEFSVRVFAENLIANCNQVGQIIYNATGKKANRTSSYVDLWQFTLVNYHAGPGCLSAAIETTAKSNMQLTWDLVSANLPPSCKSAKLYVEEIIYMPAEAATPPPLPTATPTPTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H7</accession>
    <name>E8N2H7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_07490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559176.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07490"/>
    <dbReference type="EnsemblBacteria" id="BAJ62783">
        <property type="protein sequence ID" value="BAJ62783"/>
        <property type="gene ID" value="ANT_07490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07490"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_2_1_0"/>
    <dbReference type="OMA" id="LDIPRMF"/>
    <dbReference type="OrthoDB" id="916788at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="272" mass="29726" checksum="47D15310EEE9ED54" modified="2011-04-05" version="1">MAKQKAAPISISHPLRRFVLQHRTGFFLLSLMLGILIWQGITLTGWLPAFILPGPFDVAARFWQALLDGTIPRHFFATLQEVVPGLFLGSVSASVLGYLIAKSSLLERLLSPYLVASQAIPVVAIAPLLIIWFGPGITSKILICALVVFFPVLVNTVVGLRAVPQSLHDLMRSLRAHPWQIVWYLEIPAAMPIFLGGLRVGATLSVIGAVVGEFVGADRGLGFLINVARGQYDHPLVFAAVLTLVGMALALYGLVLLAERRFLRWQIPNIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U6</accession>
    <name>E8N2U6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_30700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561437.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30700"/>
    <dbReference type="EnsemblBacteria" id="BAJ65096">
        <property type="protein sequence ID" value="BAJ65096"/>
        <property type="gene ID" value="ANT_30700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30700"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_11_4_0"/>
    <dbReference type="OMA" id="TEGCITW"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ65096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="57" mass="6053" checksum="229646335689E584" modified="2011-04-05" version="1">MTHVISKDDCIQCGACETECPEGAIYMDGEYYVVDEAKCKDCGSCVDVCPTGAIGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W4</accession>
    <name>E8N2W4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561455.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30880"/>
    <dbReference type="EnsemblBacteria" id="BAJ65114">
        <property type="protein sequence ID" value="BAJ65114"/>
        <property type="gene ID" value="ANT_30880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30880"/>
    <dbReference type="HOGENOM" id="CLU_658326_0_0_0"/>
    <dbReference type="OrthoDB" id="11991at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="417" mass="44812" checksum="58CFD39822F83C0A" modified="2011-04-05" version="1">MNDSQPAFPIRVAFQLLLSLLGLGSAWLIGLLLLGMGALGYFSGSALFHTSAEPLLALGWAFLLLGLVALPSLWAAGLRLWGKEPAPLRLNLVSASLALLLVPLIIVVGAGVLQADGVLRLFMPFFQIAVVVIPALWLVAYLTRPAQPVRAGRFWGAMNVGVFFVTPLILLVEGMLMVLMLIGVIAFLSSRPEMMQYLADLSSRLLHAAGDPEMILRIYRPILRQPLVLFGIAAIFTVFVPLIEEALKPLAVWLLAGDRLTPAEGFWLGGVCGAGFALVESLFSVIGADATSWMTLAVGRIGTTTLHITTAALMGGALAQAWQSRRYERLGLMYLLVVGLHGLWNLLALTSGLARVLEPSQPLRDILSLADRLSPFALLVLALALFWLLAIERTAVNRAGAVMPAPVLNDSVESKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z1</accession>
    <name>E8N2Z1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_31150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31150"/>
    <dbReference type="EnsemblBacteria" id="BAJ65141">
        <property type="protein sequence ID" value="BAJ65141"/>
        <property type="gene ID" value="ANT_31150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31150"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014447_0_0_0"/>
    <dbReference type="OMA" id="WVRYYAC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="777" mass="85651" checksum="53376D87524B3E4A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B4</accession>
    <name>E8N3B4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559320.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08940"/>
    <dbReference type="EnsemblBacteria" id="BAJ62928">
        <property type="protein sequence ID" value="BAJ62928"/>
        <property type="gene ID" value="ANT_08940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08940"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989185_0_0_0"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="157"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="29326" checksum="3F13E0512C21B519" modified="2011-04-05" version="1">MSGVRQLFSGLLTGLLSTILALGALSLSLAEGGKVQILPTVTETSLPSTLPPGQPSPTPYPTATPLPPTQCPPPQGWVPYEIQGGDTLVDLAARFQISIEDLSKANCLFTSQLTPGTVIFVPPLPTPTATLTTEPERPTATQPQPTVKVCGPPPGWVIYIVKPGDTLYRLSRILSVSVADLQLANCLSNPSAIQAGMPLYVPFLPITPTFTPTHTQTKTPVPPSATTLPPSPTRTPTALPPSLTPVPPTSTFTPEPPTPTFTSTPAPSDTPLPSDTPSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C4</accession>
    <name>E8N3C4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase S1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_09040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559330.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09040"/>
    <dbReference type="EnsemblBacteria" id="BAJ62938">
        <property type="protein sequence ID" value="BAJ62938"/>
        <property type="gene ID" value="ANT_09040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09040"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494218_0_0_0"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225445" evidence="2">
        <location>
            <begin position="22"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="244"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="532" mass="56539" checksum="DE949FB986A50CF8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J3</accession>
    <name>E8N3J3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable septum site-determining protein MinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">minC</name>
        <name evidence="6" type="ordered locus">ANT_09730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with MinD and FtsZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MinC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559398.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63007">
        <property type="protein sequence ID" value="BAJ63007"/>
        <property type="gene ID" value="ANT_09730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09730"/>
    <dbReference type="eggNOG" id="COG0850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048711_0_0_0"/>
    <dbReference type="OMA" id="IYKMAED"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00267">
        <property type="entry name" value="MinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01222">
        <property type="entry name" value="minC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <feature type="domain" description="MinC_C" evidence="5">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="228" mass="24931" checksum="916EF1F93EC1B0B3" modified="2011-04-05" version="1">MVTRKPQAVTIKGVRDGLLITLAEGTWQELRPALLQTMEERLGFLKGARVALDVGDQLVHAADLGALRDQFSEWGITLYAVISRSPVTEQNAQALGLATRLSIPRPERTIRPLESHIQGENAIFVQRTVRSGFKVSHHGHIVIFGDVNPGGEVLAGGNILVWGKLKGSVHAGMDGNEQAIICALELEPTSLRIAGYPLTLPPRKGKPEPQMVRMEEGRAIVETWKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L1</accession>
    <name>E8N3L1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">lgt</name>
        <name evidence="3" type="ordered locus">ANT_09910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559416.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63025">
        <property type="protein sequence ID" value="BAJ63025"/>
        <property type="gene ID" value="ANT_09910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09910"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_2_0_0"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="270" mass="30441" checksum="80BCDDB6F64C5635" modified="2011-04-05" version="1">MSIQFDGILIGTFKIYYYGVLIVLGAVAATWLASREAKRYGENPDLAWDLLPIALIGGIIGARLWHVLLPPASMVEQGITTAYYLTHPLDMLNLRRGGLGIPGAVIGGLLAVWIYSRSKKFPMGVWANAIAPGLALAQAIGRWGNYFNQELYGAPTNLPWKLYIDPLHRLPEYANVEYYHPLFFYEFLWNLLNMGILLWVARRFEGKLKPWDVFLVYAVIYGVGRFVLEFLRLDPAPLGTINANQMIMLAVAIVSAGALFWRHRRIDSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N9</accession>
    <name>E8N3N9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ordered locus">ANT_10190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559444.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63053">
        <property type="protein sequence ID" value="BAJ63053"/>
        <property type="gene ID" value="ANT_10190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10190"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_0"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="186" mass="19832" checksum="E69ECEFBFF006EBA" modified="2011-04-05" version="1">MSRIGRLPVVIPSGVQVGVDGLSVTVKGPRGTLARTFAPGVQITLEGNQVQVTRESDEPRIKALHGTTRALIQNMVTGVSTGFTKVLEIEGVGYRASMEGKNLVLNVGYSPPVVVEPPAGITFEVEERTRQIRVIGADAEQVGQIAADIRKIRPPEPYKGKGIHYLGEKIRRKAGKSGKGGKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Q3</accession>
    <name>E8N3Q3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="9" type="ordered locus">ANT_10330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559458.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63067">
        <property type="protein sequence ID" value="BAJ63067"/>
        <property type="gene ID" value="ANT_10330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10330"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_2_0"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="144"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="259" mass="29301" checksum="30353B6FDFBA3D19" modified="2011-04-05" version="1">MARYKVILAYDGTHFQGFQRQAGARTVQAEVEKALRSLGWGEESLLSSGRTDTGVHASGQVIAFDLDWRHSLEALRNALNARLPEDVAAKQVEEVPGDFHPRFNAIERAYLYRIIVAETRDPLRERYAWRLWPPLEAPEALQSAAQALCGTHDFSAFGTPPVEGGSTLRHIYQAEWRENGDEWLFEVRGNAFLYHMVRRMVWAQVQVGLNRLSLADFLEAVQQARPLPPGLAPAHGLVLTGVRYAENRQEAKNWMRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Q8</accession>
    <name>E8N3Q8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_10380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559462.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63072">
        <property type="protein sequence ID" value="BAJ63072"/>
        <property type="gene ID" value="ANT_10380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10380"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_1_2_0"/>
    <dbReference type="OMA" id="PGHPMVA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11723">
        <property type="entry name" value="YabN_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024180">
        <property type="entry name" value="Tetrapyrrole_Mease/MazG_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035013">
        <property type="entry name" value="YabN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002845">
        <property type="entry name" value="Ttrprl_mtas_MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TP_methylase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="255"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="398"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="487" mass="55327" checksum="F303046EB006191A" modified="2011-04-05" version="1">MFEQGITILGLGPGAPEMLTLQAWRHLQSIPEIYLRTRAHPVVAGFPSTLQVHSFDEVYEQSNNFSEVYRTIVERVLEEAQRNGTVTYAVPGHPFVAEATVPEIVRRARELHIPVRVIEGVSFLEPVFTALEIDPFPRAVLVDALELGALHVPNFPTDVPALIAQIYSRQIASEVKLTLNAFYPDEFRVRLVHAAGTPQQKVEDLALYEIDRSPHIGLLTALYLPPLDEATSMEAFLEIVAHLRAPDGCPWDREQTLQSLGPMLLEETYEVLEALDQEHVENLQEELGDVLLLISMLSQIASEEGYFAFPQVVQGIHRKIVRRHPHVFGDVDLKDSRGVLRNWEKLKEAERKENGTAEQKGILDGVSKALPSLVRAQEYQSRAAHVGFDWSDIQGVREKVMEEWEELRQANSPEEIEKEVGDLLFAVVNLSRWYKVDAETALRKANERFMARFKHIEQEARVMGKPLADLTMDEMENLWQQAKRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3U2</accession>
    <name>E8N3U2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transport ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cydD</name>
        <name evidence="10" type="ordered locus">ANT_10720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559496.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63106">
        <property type="protein sequence ID" value="BAJ63106"/>
        <property type="gene ID" value="ANT_10720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10720"/>
    <dbReference type="eggNOG" id="COG4988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_0"/>
    <dbReference type="OMA" id="FPLNWAA"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    </feature>
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            <end position="379"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ63106.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="578" mass="63842" checksum="E7DD405CDB79DB61" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N419</accession>
    <name>E8N419_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">ANT_11490</name>
    </gene>
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        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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            <end position="153"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ63183.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="513" mass="57585" checksum="43F68DB0BB0A3E7E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">ANT_11560</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
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            <taxon>Anaerolineales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
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                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ63190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11560"/>
    <dbReference type="EnsemblBacteria" id="BAJ63190">
        <property type="protein sequence ID" value="BAJ63190"/>
        <property type="gene ID" value="ANT_11560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11560"/>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="GLIGMEH"/>
    <dbReference type="OrthoDB" id="1695683at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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            <end position="31"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ63190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="488" mass="55195" checksum="BA33FD95B28DDC66" modified="2011-04-05" version="1">MSLFRERGRWSNIVALLLVGAGVFLYLWMSYRTYRIGFPLDDAWIHQTYARNLAKIGEWAFVPGQPSAGSTAPLWSLLLALGHFLSSGIPYTWTFSLGVCSLIGLMILGQRWFERETGVFFPFAAIFLGLEWHLLWAALSGMETAFMACLVLAVLWLVGESRSRWGWMGILIGGGIWVRPDAITLIAPVFLMWLWRFSRGETCWRDAVKFLTGFLLLFTLYMGFNLLLSGSIFPNTFYAKQAEYAVLYERPLLLRFLRSFGVMLVGGSGLLLPGFLWGIYQAWKNKNVAFLLASVWVLGYVALYALRLPVTYQHGRYLMPAMPVYFVLGLIGTAQVVRSLNQSRWGWVLSRVWLGSMLGVTLGFVLLGAQAYATDVAIIESEMVETAYWLAANTPPNALIAVHDIGAVGYFAQRRLVDLAGLVSPEVIPFIRDESRLRAYLDQQQVDYLVTFPGWYQYLAEGKPLVYQSRGKFSPRAGGENMCVYRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N430</accession>
    <name>E8N430_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fba</name>
        <name evidence="4" type="ordered locus">ANT_11600</name>
    </gene>
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        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559582.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11600"/>
    <dbReference type="EnsemblBacteria" id="BAJ63194">
        <property type="protein sequence ID" value="BAJ63194"/>
        <property type="gene ID" value="ANT_11600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11600"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_0_0"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="316" mass="35027" checksum="CA80B1F4E92CF911" modified="2011-04-05" version="1">MIVTTKKLFEAAYGKYAIGAYNINNLEQCMGLFRGNLESQAPFIIQISKGARKYTDKRMLEAIIRAADEIFPDAIFAVHLDHGDEETCMDAIESGFYSSVMIDASHEDFETNIAITRRVVEAAHARGIVVEAELGQLGGVEEHVSVDESNAKLTDPDNAKEFVERTGCDSLAVAIGTSHGAFKFTGNQTLRFDVLAEIQKRLPGFPLVMHGSSSVPQEEVERINRAGGNLKGAKGVDENQFRRAAELGVTKVNIDTDGRLVWTRVHREYFRDHPEEIDMRPIGKIFMAEYAKFIAHKNEKLGSAGRLPEVRALLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N436</accession>
    <name>E8N436_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_11660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559588.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63200">
        <property type="protein sequence ID" value="BAJ63200"/>
        <property type="gene ID" value="ANT_11660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11660"/>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083873_6_3_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="151" mass="17057" checksum="4C8DFCE4C35811B7" modified="2011-04-05" version="1">MILSNPRERERFLKFAVVGVIGAIVDFGLFNLSIAFLGMPAVWASALSFTAAVISNFTWNRFWTYPDSRSKQLSQQLAQFALVSAIGLGIRIPMVATLEIPMINLFTRILPRSFIFTPTFAGHNVTLAIAVLVVMMWNFFANRFWTYNDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N445</accession>
    <name>E8N445_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_11750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559597.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11750"/>
    <dbReference type="EnsemblBacteria" id="BAJ63209">
        <property type="protein sequence ID" value="BAJ63209"/>
        <property type="gene ID" value="ANT_11750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11750"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="EYMWEFE"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="241" mass="27043" checksum="ED7EE09CD65E3339" modified="2011-04-05" version="1">MNRILIVDDEEVARLSLAEILKLEGYLIRTAASGEAAVDLLRRETFDVMILDLKMPGMGGMDVLRTIVDTLPDLKVIVLTAHGSMDTAIQALRYRVHDYLLKPATPAQIIKSIQGALEQRQREKYHAELLARAPQLMSFPGGAEMDLNRRIIRWRGGEVSLTPTEAKLLGILYQLKGQVITHSELVLICQGYRVDNEEAARILRPVVSRLRQKLESVPGWNEWIKNVRGSGYVLDFTSAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N458</accession>
    <name>E8N458_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_11880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559610.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63222">
        <property type="protein sequence ID" value="BAJ63222"/>
        <property type="gene ID" value="ANT_11880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11880"/>
    <dbReference type="eggNOG" id="ENOG5032R2G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890906_0_0_0"/>
    <dbReference type="OrthoDB" id="1090654at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="365" mass="41665" checksum="C9E197CFF8F4DCB3" modified="2011-04-05" version="1">MRGWIRRLILLSLFIPWMVQKIPASFAQQSTPEPRLFLPVIMHQKNQYGPEIYTTSYYIKSLDPTLMYNRGCELGKRDLALPGTQENLVILDFGGPRYFENASGQKVYGTKLFYPGGRVSTDEIAEAVKWYAMGYYVCTGEDTTSFVLVGIGTNNYEYDDCGDYCAVNYAHGQAWAQMVNAVNRWLTENNMFAQVRAVGANDIELSWNDYARTRDWLDGYDSVNEAIMVNFGAIPGCPYFAAPGSTCGSYRCYDIDKSCVWSKEQVWYVIWGSKPVYPVPEIYSNNGVNAQQWYLMSVYGYTAHGYPVEFLGVMTQYQACKDKPSDPTCEYLDNTPLEGWTQLQTLLNGDSRVKHEIKYSTDIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N479</accession>
    <name>E8N479_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559631.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12090"/>
    <dbReference type="EnsemblBacteria" id="BAJ63243">
        <property type="protein sequence ID" value="BAJ63243"/>
        <property type="gene ID" value="ANT_12090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12090"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_854278_0_0_0"/>
    <dbReference type="OrthoDB" id="991474at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225270" description="Beta-lactamase2 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="103"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="36962" checksum="ECA391880B73BEAF" modified="2011-04-05" version="1">MRNWQKRLLGLSLGVLLWGMASCNSSMSQSLTALPVSSENTIPIPSFSPTPSPVIIPETSEPLPSITQAPAFQSFAVQPLSQMLEDGADWHVWVKELGGRVLFEWRSDEIIHPASIVKVPLGMLVLETLEKGTEEPLDLVLDKGPTGAGRSYRQLLRAMLVYSEEDATEILERDLFERVHQNAVQQILDRWQAPSIRFRPRRASIHDLSTLWECLYTRQCLSESASEQMLTWLAEETPSDNGRLWTLKPYLPEESRIYNKRGSMTVPLTVGDCGLVEIPYYPVLLICIVGQSQGEPNFDRLHQKIGEFVQEVWVLWQDYREIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N481</accession>
    <name>E8N481_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63245">
        <property type="protein sequence ID" value="BAJ63245"/>
        <property type="gene ID" value="ANT_12110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12110"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536026_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="517" mass="56607" checksum="B1644C3B6E4E1F64" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A3</accession>
    <name>E8N4A3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559655.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63267">
        <property type="protein sequence ID" value="BAJ63267"/>
        <property type="gene ID" value="ANT_12330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12330"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089937_1_0_0"/>
    <dbReference type="OMA" id="WETPEYV"/>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="270" mass="30220" checksum="F8A8732707735174" modified="2011-04-05" version="1">MNVKTIVETILQKCNVPPMEQTCDQLIVGDWNAEVTGIATTFMATVDVIKEAAAKGANLIITHEPTFFTGWDKTEWLKDDPVYTGKQALIHQHQINIWRFHDHMHGSTPDLIYDGLIRELGWETYQNADDKHCFTIPKISVVDLAEFLEERLQVSVSRIVGAVNGSVERVGFLVGGGSLGLGREEMPMELMNKANLDTIVCGEILEWTLAAYVHDAAQLAMNKSLIVLGHNRTEEVGMKHLVSWLQALFPKIPVDFIEAGDPFIYHVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B9</accession>
    <name>E8N4B9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NarL family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_12490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559671.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12490"/>
    <dbReference type="EnsemblBacteria" id="BAJ63283">
        <property type="protein sequence ID" value="BAJ63283"/>
        <property type="gene ID" value="ANT_12490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12490"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="LDKYATH"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="215" mass="23302" checksum="2DB135CCBF49EF7B" modified="2011-04-05" version="1">MKKIRLLVVDDHVVVRKGLMAILETEPGIEVVGEAGDGNEAVEKACALQPDVVLMDLVMPGMDGIEATRLIKQRVPQVQVLVLTSFSTNDKVIPSLSAGATGYLLKDASPEELVKAIEQVAQGEGALHPAVTRYVLGQIKNMPDEPAPEEELTEREKEVLQFMAQGYSNAEIARLLVVSNATVHTHVSRILSKLNVSSRTQAVLYALKRGIVSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F0</accession>
    <name>E8N4F0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12800"/>
    <dbReference type="EnsemblBacteria" id="BAJ63314">
        <property type="protein sequence ID" value="BAJ63314"/>
        <property type="gene ID" value="ANT_12800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12800"/>
    <dbReference type="HOGENOM" id="CLU_1192804_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="232" mass="25999" checksum="9767A33C51800E6B" modified="2011-04-05" version="1">MILVIAFLCITIGYVFGWLVATWRAGKEKDETEELLSKAVSPSPERPFPLLLGVFQDPISRRIQVEWKGQKVEKALDLSADERGKLLGTLSDVKEWLGAPELPLKVSSVSVESPRPSEPVVPPLPEEPVRPPSILSGVTSALADAMQPPRQEKPKSIVEQIDEIFQKKLEGTPYEGKRIFLMEDPRRGVLVRIEGQVYEGVENVPEGEVKQLLRSAVSEWERSQELQIKRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I0</accession>
    <name>E8N4I0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recJ</name>
        <name evidence="10" type="ordered locus">ANT_13120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559731.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63344">
        <property type="protein sequence ID" value="BAJ63344"/>
        <property type="gene ID" value="ANT_13120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13120"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_5_2_0"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="7">
        <location>
            <begin position="80"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="8">
        <location>
            <begin position="322"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="9">
        <location>
            <begin position="457"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="565" mass="62404" checksum="A606A2E942110E2C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K1</accession>
    <name>E8N4K1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559752.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63365">
        <property type="protein sequence ID" value="BAJ63365"/>
        <property type="gene ID" value="ANT_13330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13330"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_0"/>
    <dbReference type="OMA" id="MGPWTDI"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="331" mass="37125" checksum="AC93B76C790DBB99" modified="2011-04-05" version="1">MPVPIKPGEVLRGRYKIRRVIGQGGVGCIYLADDLRLEGRTCALKEVEHDRSLPPDLLREAREQFLREATILARLDHPNLPKVSDFFSVGNRDYLVMDYVPGKDLRTLMVEARQAGIFLSEEDVLAWASQLCDALEYLHGQNPPILHRDIKPSNLKLTPSGLLKLVDFGLVKLAAPGEVTITILQGQGTALYTPLEQYGGDSGHTDVRSDIYAFGATLYHLLTNHPPADARERFLNPEKLIPPRQINPSLSPRTERAILWAMALHPDERPESVRQFRLALFGEDAVPISRPLPRTVTQRSVWGFLRFPLERTLLGTSLVLITLGLLITLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4M6</accession>
    <name>E8N4M6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_13600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559776.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13600"/>
    <dbReference type="EnsemblBacteria" id="BAJ63390">
        <property type="protein sequence ID" value="BAJ63390"/>
        <property type="gene ID" value="ANT_13600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13600"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_29_1_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="4">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="266" mass="30320" checksum="21AFF44F05D96DE2" modified="2011-04-05" version="1">MEHNSKIPVLLVEDNPVNQRVAMMMLQKLGFQPDFAGNGQQALKMVKEKALLESYPYKVVFLDIFLPDIDGSEVCRRIRAELPLKDQPFIVALTADESQENLKHYIDDGMDAILIKPLKMSELQEVIDIFQKKNLILKAQSEEIDWRNTGEVLHLPTLRKWQEMLGGKDAFRNVVSIYIKDARLLFEGIERGVAEDNWKLVHRNAHTLKSTSANLGALGLASVLEEVELIAYENLTGDFPRSVTDLICQARDCLKKVLQELETYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S4</accession>
    <name>E8N4S4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_14100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14100"/>
    <dbReference type="EnsemblBacteria" id="BAJ63438">
        <property type="protein sequence ID" value="BAJ63438"/>
        <property type="gene ID" value="ANT_14100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14100"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_634084_0_0_0"/>
    <dbReference type="OMA" id="ATTLMTQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="432" mass="47813" checksum="718FFB5BAD4DE83B" modified="2011-04-05" version="1">MNRSPSSSRIVRKRTRRLHPVRVKATVNRWDSTTKLVVSLALFTILAWLLVRFRNIVGPLLLAVLLAYLLYPMVSSIQRATRISWRLAVGIVYFLLLLLVLGGTTLSGLAVVEQSQSLIRFLQQTLKDLPSLLTQWSEMPVQVGPFQFVLPNFMDVNTLTQSLLGIVQPLLSRAGLLVGSIASGAFNFLGWVFFILLISYFILAESGGTSPEIIRINLPGYNEDLRKFGVYLSGIWNAFLRGQIIIILITILVYTALLGILGLRFFIGLALLAGLARFIPYVGPAVAWTSYGLVALFQGSNYFGLPPWGYVILVVGLAWFTDVILDNLVATRLMGTALKIHPAAVMVSALIGANLFGIIGVVLAAPVVATLKLLTSYVVYRLSDQEPWENLQVAAPVVSRPIFSRIRSIIYRAVQMLRKGIKKYGKPIRTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U1</accession>
    <name>E8N4U1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pyruvate dehydrogenase E1 component beta subunit</fullName>
            <ecNumber evidence="2">1.2.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdhB</name>
        <name evidence="2" type="ordered locus">ANT_14270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.4.1" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559837.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14270"/>
    <dbReference type="EnsemblBacteria" id="BAJ63455">
        <property type="protein sequence ID" value="BAJ63455"/>
        <property type="gene ID" value="ANT_14270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14270"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_1_0"/>
    <dbReference type="OMA" id="SRMRHHC"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="35589" checksum="A4DD27D54D4FDE59" modified="2011-04-05" version="1">MARITMREAISQALWEEMERDPNVFILGEEVGVWGGTYAVTKGFYDHFGPERVRDTPIAEAGIIGAAIGAALTGLRPVAELMTINFAFSAMDHIVNQAAKLHYMFGGQMVLPMVIRAVGGGGRQLGATHSQTPDAVFAHFPGLKVVAPGTPADAKGLLKAAIRSNDPILFIEHATLYQMRGEVPEGDYTVPIGKSTIQRPGRDVTIVTYSKMLEISLKAADQLAKEGIEVEIVDLRTLRPLDMEPVLESFKKTNRAVIVEEGWKSYGVGAEIASRIYEEAFDYVDAPIRRVAQKEVPLPYNRTLEQMALPKVEDVIQAVKEVLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V6</accession>
    <name>E8N4V6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559852.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14420"/>
    <dbReference type="EnsemblBacteria" id="BAJ63470">
        <property type="protein sequence ID" value="BAJ63470"/>
        <property type="gene ID" value="ANT_14420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14420"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094015_1_0_0"/>
    <dbReference type="OMA" id="EWIPHIT"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="182" mass="21028" checksum="15DE17D90DB705E8" modified="2011-04-05" version="1">MFFAVVSLLALENNPAFSEVWTRLKKIFSRYGLELVERPHISWHVSPVYDMEKLEKNLQGLTQGRRQIRASISGLGVFTGKKPVFYLPVVRSPQVHEIHRTIWAEISPCALNQELYYSPEEWIPHITLNRKAFSCNVGEVFQELCSLDLRCEVWLDNFAVIYRDDAHDGVGTIFPFSKEKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X7</accession>
    <name>E8N4X7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559873.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14630"/>
    <dbReference type="EnsemblBacteria" id="BAJ63491">
        <property type="protein sequence ID" value="BAJ63491"/>
        <property type="gene ID" value="ANT_14630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14630"/>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050189_0_0_0"/>
    <dbReference type="OMA" id="GSVEPHY"/>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="420" mass="46361" checksum="BCAFA80CC93DBAF5" modified="2011-04-05" version="1">MQQITIPFGSGTQSCSISDEHSIEWIVPPEIPGSENPLKVIEKALSHPLDFQFPSGIDHVAIAVNDKTRPVPHHHILPPLLDWLNQHHIPDEKITLLIATGTHLPMKQEEIRSLIPLEVLERVNCISHDCDNAEQLVFIGVTSRGTPVWVNQKFAQADLKICTGDIEPHHFAGFSGGVKTAAIGLAGRKTVNRNHAWITDPKAWIGIYEGNPLREDIEEIGSLMGVDFVLNTILNEKKEIVHALAGHPRQVMKTGIPLALKICTTEDKGLFDLVIASAGGYPKDINFYQAQKALTHATTIIRKGGTIILVAECREGSGNQAFEEFMKDVSTPDEVFAKFAQQPFRVGPHKGYQVARIVRDYHVYLVSTISPEIVRNWLIQPCDTLKNAVNLALADIKGIVRIGVMPYATTTLTVSSSNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N544</accession>
    <name>E8N544_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endopeptidase La</fullName>
            <ecNumber evidence="3">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_15300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559940.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15300"/>
    <dbReference type="EnsemblBacteria" id="BAJ63558">
        <property type="protein sequence ID" value="BAJ63558"/>
        <property type="gene ID" value="ANT_15300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15300"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_2_1_0"/>
    <dbReference type="OMA" id="FDELACN"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="5">
        <location>
            <begin position="298"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="502" mass="56275" checksum="50DCEC590DB47C07" modified="2011-04-05" version="1">MDFGELPWHQQTEDNLDVEHAAKVLDHYHFGLKDAKDRILEYIAVRSLQPKRLRQPILCFSGPPGTGKTSLGRSIAEALGRNFVRVSLGGVRDEAEIRGHRRTYIGALPGRILQTMRRAGTINPLFMLDEIDKLGADFRGDPAAALLEVLDPEQNHAFSDHYLEIPYDLSKVMFITTANSLASIPPALLDRMEVIEFPGYIEEEKVEIAKRFLIPRQIEESGLQDKEVVFRDAAIRRIIREYTYEAGVRNLEREIGRMCRKVARLKSQKKRYPSQLTPHLVEKFLGPPQFFVSEAERQDEVGVATAMAWTETGGEIMPVEVLIMEGKGNLQITGQVGDIMQESAQAALSYLKAHCSDFDLDPSVFEGLDIHIHVPEGAVPKDGPSAGITIATALASAFTERKVYREVGMTGEITLRGRVLPIGGVREKILAAHRAGLKTVILPEKNKKDLVDVPKKVLSDLKIVFVTHIDEVFRVALHPSSDNPVQPRWKAKKEEKNEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N560</accession>
    <name>E8N560_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_15460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63574">
        <property type="protein sequence ID" value="BAJ63574"/>
        <property type="gene ID" value="ANT_15460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15460"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_0"/>
    <dbReference type="OMA" id="VMDVFDY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="404" mass="45095" checksum="E2D6C49CF69DA788" modified="2011-04-05" version="1">MIGSSLVKKIILKPGREKSLLQRHPWVFSGAVEKVIGNPEIGETVAVCDSAGHFLGWGAYSPSSQIRVRVWSFDEEEKISAEFFYNRIQTALWIREKSVLLRDTNAYRLVHAESDGLPGLIVDRYSDWLVVQFLSAGANYWKKEIVSVLSELGVGGIYERSDVEVRRLEGLSETRGVLWGKEPPSIIRVKENGFQFAIDIQTGQKTGFYLDQRVNRERLQEYCQGKDVLNCFCYTGGFTVYALAGGANSVLSIDSSDGALALADENVKLNQLPEERNRWLEADVFLALRKFRDEGRSFDLIVLDPPKFASTAAQAQRAARGYKDINLLAIKLLKPGGILFTFSCSGGITPELFQKIVAGAAIDARADVQILERLYQSPDHPVLLTFPEGEYLKGLVCIKRPTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N564</accession>
    <name>E8N564_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63578">
        <property type="protein sequence ID" value="BAJ63578"/>
        <property type="gene ID" value="ANT_15500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15500"/>
    <dbReference type="HOGENOM" id="CLU_958588_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="31562" checksum="AD46184FEADB27AB" modified="2011-04-05" version="1">MSILGMINDFRNHVRSGIIRRPVWEKINGAAFIVLGLLALIAQLLHIPYFWGIAFVGMGLVFTLGGWRFSFPVYVYLGNLIMALGIGMLLLLSSGAITFEKLGNLFGVISSGFFIASLAVYLRFKRFFWWSLFPTAVFGGLSVVFVFTSSRWVDFVFWMGILLGVAFLLSGGYLKLVGLVIPGCLLSAIGLGVHFGFGVGESTSIISDVGVLLLWFAAGWGAIPLFARWWCDYLPLWPMIPAGVIGIVGLGLFIGGNPDNAAFFIGNTSAVLFIAIGLYLILLRRGMHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N568</accession>
    <name>E8N568_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome oxidase assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_15540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15540"/>
    <dbReference type="EnsemblBacteria" id="BAJ63582">
        <property type="protein sequence ID" value="BAJ63582"/>
        <property type="gene ID" value="ANT_15540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15540"/>
    <dbReference type="eggNOG" id="COG1612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053655_0_0_0"/>
    <dbReference type="OMA" id="HWPLCNG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="35015" checksum="F5CC020A8B9E4A1F" modified="2011-04-05" version="1">MKRISFFAWGVLVYNIFVIVFGAFVRATGAGAGCGSHWPLCNGVVIPRSPQIETLIEWTHRLTSGVTVLLIFVMLLWVWRVAWGEKKLRYAVLGSVFFILVESLIGAGLVLFGLVGENASMARAISMMAHLVNTFMLLASLTGVAWFATFTFSSEIRNAKRVSGWLLGALGMLILGASGAIAALGDTLFPSSSLLEGLRADFDPLAHFLIRLRVFHPAIAVAVGGYLIFFIRYLVSREMSPWLRKIGYGVITLIITQWVLGIINVITLAPVGIQLFHLLLTTLVWIGYVIIGIFCWRGSHFSLRISEHPIHDGVNGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N572</accession>
    <name>E8N572_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Indolepyruvate oxidoreductase subunit IorB</fullName>
            <ecNumber evidence="3">1.2.7.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iorB</name>
        <name evidence="3" type="ordered locus">ANT_15580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.8" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15580"/>
    <dbReference type="EnsemblBacteria" id="BAJ63586">
        <property type="protein sequence ID" value="BAJ63586"/>
        <property type="gene ID" value="ANT_15580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15580"/>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_1_1_0"/>
    <dbReference type="OMA" id="HGMSQRF"/>
    <dbReference type="OrthoDB" id="1603697at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="202" mass="21939" checksum="B690B96470BA7EE4" modified="2011-04-05" version="1">MHMENHRFVLVGVGGQGTLLASHLLAEIGLSLGLDVKKAEIHGMSQRGGSVVSNVVWGKPVFSPVVGEGEADTLIAFEKLETLRYLPLLKPSGAIFVNDHEIEPITVSAGKQIYPNNADIEATLHKFTTKVFWIPANQIAEDLGSARVANTVMIGVVLKGLGVELDYGVRTLEKTIQSRYLELNLRALKAGYDWLAISNHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D0</accession>
    <name>E8N5D0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine kinase</fullName>
            <ecNumber evidence="4">2.7.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adoK</name>
        <name evidence="4" type="ordered locus">ANT_16180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.20" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560024.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63644">
        <property type="protein sequence ID" value="BAJ63644"/>
        <property type="gene ID" value="ANT_16180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16180"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_5_2_0"/>
    <dbReference type="OMA" id="SQQIARM"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="30"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="35844" checksum="19CAC70B82206009" modified="2011-04-05" version="1">MKIVVTGSVAYDYLMTFPGFFRDHILPERLETISLSFLVDSMVRQRGGTAPNIAYTLALLGEKPSVLATVGEDFGDYRTWLENHGVDTSLIKEIPGLYTASFFANTDQANNQIASFYPGAMAFASRLSLRDITSKPDLVIISPNDPLAMDQYVRECKELGIAYVYDPSQQVVRVSGEELRRGVDGAHSLFVNEYEFGLLQKHTGFSAAEIIQRVGFVVVTLGAKGADIYADGVRYHVEAVPPKQILDPTGVGDAFRGGFLRGYSLGLDWETCGRMGSVAAAYCLEVKGPQEHSYTIEEFVARYRQNFDDGGKLDILLKSKVAHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D9</accession>
    <name>E8N5D9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_16270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560033.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16270"/>
    <dbReference type="EnsemblBacteria" id="BAJ63653">
        <property type="protein sequence ID" value="BAJ63653"/>
        <property type="gene ID" value="ANT_16270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16270"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_777656_0_0_0"/>
    <dbReference type="OrthoDB" id="1795869at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="155"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="290"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="356" mass="39869" checksum="A51C6D4967D48B72" modified="2011-04-05" version="1">MKVSLRALVVDDDPSWLELLSEILEEVGYHVDCAINLVQANDLLKKPYHLAIVDLSLDTYDHRNQDGLKVLEQIHRQYPDCATILLSGYATVEIAVSVIKDLGGYTCLRKEVFRRSEFRSLIAKLFEQITITEQLSATKFDSRRSKTEQSPISPNILVIEDDAGWRDLLEEILLDAGYSVRVCTGYGDAQGILRREHFSLVILDLNLAGNLPENPRLLKGEALEQLEGFRLLASARASGAQIIVISGLSSPNIIDKMFKRGKIFAYLEKHSFERRGFLQTVREALIMGGKSDDLSSLTEREREVLLLLAQGLTNREIAEALVISNNTVKRHLKSIFSKLNIHTRSAAVAKVAGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E1</accession>
    <name>E8N5E1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">fhs</name>
        <name evidence="7" type="ordered locus">ANT_16290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560035.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63655">
        <property type="protein sequence ID" value="BAJ63655"/>
        <property type="gene ID" value="ANT_16290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16290"/>
    <dbReference type="eggNOG" id="COG2759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_3_3_0"/>
    <dbReference type="OMA" id="CGEIMTM"/>
    <dbReference type="OrthoDB" id="177859at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="82"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="635" mass="68844" checksum="69753D3ABC282434" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H4</accession>
    <name>E8N5H4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560067.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16620"/>
    <dbReference type="EnsemblBacteria" id="BAJ63688">
        <property type="protein sequence ID" value="BAJ63688"/>
        <property type="gene ID" value="ANT_16620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16620"/>
    <dbReference type="eggNOG" id="COG0647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_1_2_0"/>
    <dbReference type="OMA" id="MDGVLIH"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="28361" checksum="6888AABB20C8CABE" modified="2011-04-05" version="1">MREIRGLILDMDGVLWRGKEPLLDIQKFFDQIQELGLKVVLATNNATKSVDQYLEKLSRYGISLQPQQIVNSAMSAAYYLKRRFPHGGPVFVVGEQGLIDTLQEAGFYPAEENVLAVVAGLDRTLNYPKLSQASLLIRKGALFVGTNPDKTFPSPQGLTPGAGAVLAFLETGSGVKPVITGKPEPYLFELALERMCLEPSHVLTVGDRLDTDILGAQRTGCQTAAVLTGVSSLEEIQAWNPPVDLILENLVDLIPFLRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K6</accession>
    <name>E8N5K6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_16940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16940"/>
    <dbReference type="EnsemblBacteria" id="BAJ63720">
        <property type="protein sequence ID" value="BAJ63720"/>
        <property type="gene ID" value="ANT_16940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16940"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_656638_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="156"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="418" mass="46972" checksum="2B5A1AF3540CEC03" modified="2011-04-05" version="1">MQELELLRQIRQPWVQRSPQTLARAVNIREDLRNQLEQFFDRMEVSLETGTYSWMDPILSAWAEALPQSESPEMSSSLVDFIGDLLLFTVKVCEETLKPEYSVAITSGLLPIFLYCFRRAFEMEMEIRIRAISEQLQQVQQTLEKLDQSKSDFIAVAAHELKTPLTLVDGYAAMLRDALSTRNLSPYEIDLLNGIHNGTRRLKTIIDDMIDVSLIDNNLLSLNFQPVWINRILHVLENELQGVIKERQQTLTIQDFPGSGEMTFGDPERLLQVFRNVLTNAIKYTPDGGSISVDGRKLPGFIEVIIKDTGIGIDPEDQLLIFDKFARLGKTDLHSSSKTKFKGGGPGLGLHIAKGIVEAHGGAIWVESPGFDEKTCPGSTFHILLPLMTQPPDEKMARLLAPLTHKPAKKPLLGSRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U6</accession>
    <name>E8N5U6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">hypA</name>
        <name evidence="5" type="ordered locus">ANT_17840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560188.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63810">
        <property type="protein sequence ID" value="BAJ63810"/>
        <property type="gene ID" value="ANT_17840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17840"/>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_4_0_0"/>
    <dbReference type="OMA" id="ILLCPCG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00100">
        <property type="entry name" value="hypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="127" mass="14544" checksum="E350465666C645CB" modified="2011-04-05" version="1">MHELSVTEHILNLALQYAEKNQATRVTDIYLVIGRLSSFVDDSIQFYWDLISQNTLCEGAALHFERVPARLLCLNCEQEFEIHTELAPCPNCFSTRVKVLTGEEFYLDSIAIETTTEKENEQSSDHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5X6</accession>
    <name>E8N5X6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-oxoglutarate ferredoxin oxidoreductase beta subunit</fullName>
            <ecNumber evidence="2">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560217.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63840">
        <property type="protein sequence ID" value="BAJ63840"/>
        <property type="gene ID" value="ANT_18140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18140"/>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_0"/>
    <dbReference type="OMA" id="NTVHGRM"/>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="57"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="346" mass="38275" checksum="C2BF3ABD88188AB7" modified="2011-04-05" version="1">MADIQALNAIGLSRTDYRGLPSTLCQGCGHNAVSNQIIQAMYEMNIQPEKIVKFSGIGCSSKSPAYFLGRSFAFNGVHGRMPSLATGALFADTSLYGMGVSGDGDTASIGMGQFKHVIRRNLPMVYIVENNGVYGLTKGQFSATAEKGLTLKHEGTNLFLPVDICLEALASNATFVARGFAGDPKQLKELLKAAIKHRGTAVLDIISPCVTFNNKDDTIHSYAFGKEREVRLHDLIFVPARDQLTIEDFEEGTVRDVELYDGSVITLRKLERDYDPTSRSEAFRILEEARERRELITGLIYVEPDAPSIFDLYELPEKPLNRMTEGELRPASQTLNQVHSWLFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N604</accession>
    <name>E8N604_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560245.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18420"/>
    <dbReference type="EnsemblBacteria" id="BAJ63868">
        <property type="protein sequence ID" value="BAJ63868"/>
        <property type="gene ID" value="ANT_18420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18420"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_342168_0_0_0"/>
    <dbReference type="OrthoDB" id="1623808at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="139"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="828" mass="93606" checksum="6CE6610644B9FBA9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N608</accession>
    <name>E8N608_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_18460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560249.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63872">
        <property type="protein sequence ID" value="BAJ63872"/>
        <property type="gene ID" value="ANT_18460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18460"/>
    <dbReference type="eggNOG" id="COG1496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065784_0_0_0"/>
    <dbReference type="OMA" id="CFADCVP"/>
    <dbReference type="OrthoDB" id="1393323at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="262" mass="28885" checksum="94AAA99D4E7F6B31" modified="2011-04-05" version="1">MRYVSSGEVRFLKADLLDTEPIFHGFFTRHGGVSPSPWASLNMATSVGDSRENVLENRARALRALTPEPRGIFDVWQVHSNRVVYTRQPRSLGEPHQQADAIITDNPEVVLLMMFADCVPILLFDPGHHAVGIAHAGWKGTVAKVARESVLSMKQAFGTKPEDLLAVIGPSICPEHYAVGSEVTHAVREAFGNDSSEVLLQENGVISLDLWRANQIILTQAGVLADHIQTVEICTAEHTRDWYSHRAEMGKTGRFAAMIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8N642</accession>
    <name>E8N642_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_18800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18800"/>
    <dbReference type="EnsemblBacteria" id="BAJ63906">
        <property type="protein sequence ID" value="BAJ63906"/>
        <property type="gene ID" value="ANT_18800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18800"/>
    <dbReference type="HOGENOM" id="CLU_3148848_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="48" mass="5453" checksum="0F0E2F103F449DAB" modified="2011-04-05" version="1">MQHLKVYTCHSILLKRKGYPEVNCQNAIVILKAYLAGLEGKFIFSVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N651</accession>
    <name>E8N651_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560292.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63915">
        <property type="protein sequence ID" value="BAJ63915"/>
        <property type="gene ID" value="ANT_18890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18890"/>
    <dbReference type="HOGENOM" id="CLU_2663057_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="75" mass="8309" checksum="36BCD92F927D94DD" modified="2011-04-05" version="1">MLDDLRNSASSSFEEIEQESPTVIPDTPKRPGKKSGEFLGMTPFQRFIIVLLLFMMTCVLGAFCLIAFGKVVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D4</accession>
    <name>E8N6D4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63998">
        <property type="protein sequence ID" value="BAJ63998"/>
        <property type="gene ID" value="ANT_19720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19720"/>
    <dbReference type="eggNOG" id="COG1594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651587_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="421" mass="47742" checksum="BC6AEF8FBC38BD8B" modified="2011-04-05" version="1">MPSLDYELLSYGRASAMAGEKETARRYLEGFLRRSPPEDERLEALYWLSEVIDDPQEKRALLEEILACNLGDVRARKKLAILDGKIQPEEIVDPDHLPAPKENRTNGARSFTCPQCGGRMTYAPDGQSLICEYCESQSRLRNRQPAEEENFLLALATAKAQRRPIQQNVIECKGCGATFTLPPKVITHTCPFCQTPYAIEQVEIRELDAPDSVLPFKITHEETRKIIIKWLKENPPDEKPLLKSFYGVYLPAWIFTIGGQVDWTGWVYKNKKAVPVQGRRIINIPNILIPAVNNFPSPLEPVFRSFPLDELVAFDPGYLASFHAETFQISAADASLKAREMAVQKIKQDVPSTELSDIYNLTVKTPSIVVESYRLALLPLWMVTLDIGKEQLHMAINGYTGESFADKEHPPFHWLKKLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D6</accession>
    <name>E8N6D6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AhpC-TSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560373.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64000">
        <property type="protein sequence ID" value="BAJ64000"/>
        <property type="gene ID" value="ANT_19740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19740"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177870_0_0_0"/>
    <dbReference type="OMA" id="FGRMPAV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="105" mass="11969" checksum="E036CBE1902189D3" modified="2011-04-05" version="1">MRQDYQKFVERGAEIIAIGPDGPNAFRKYWQENKIPFPGCADLRSRVANRYDQEVSLLKFGRMPALFIVDKQGMIRYSHYGDSMADIPSNESILNLLAELTAEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6F1</accession>
    <name>E8N6F1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_19890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560386.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19890"/>
    <dbReference type="EnsemblBacteria" id="BAJ64015">
        <property type="protein sequence ID" value="BAJ64015"/>
        <property type="gene ID" value="ANT_19890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19890"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083279_0_0_0"/>
    <dbReference type="OMA" id="CVPPQNK"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="49"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="230" mass="26451" checksum="803D82BAE892F596" modified="2011-04-05" version="1">MTPENALQELNHALVQCKRCERLTHWREHIAQTRKKAHRDEVYWGKPVPGFGDPHAEVMIIGLAPGAHGSNRTGRMFTGDSSGHFLYAALYRAGFANQPHSHALYDGLTLRRVYITAICRCVPPDNKPTPQEIQNCRPYLEQEIALFPQLKGFVALGNYAFQWLVQWYRQHGENDTREWQFAHNAFYAPRNGLPWLLASYHPSRQNTQTGRLTQPMFDEVWQRVNSLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXE5</accession>
    <name>E8MXE5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmhB</name>
        <name evidence="9" type="ordered locus">ANT_20000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gmhB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560397.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20000"/>
    <dbReference type="EnsemblBacteria" id="BAJ64026">
        <property type="protein sequence ID" value="BAJ64026"/>
        <property type="gene ID" value="ANT_20000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20000"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085077_2_0_0"/>
    <dbReference type="OMA" id="EHQICLE"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to substrate recognition" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="186" mass="20266" checksum="B737DA1EC667891A" modified="2011-04-05" version="1">MNAAIFLDRDGVIIENRDQYVLGWEDVAFIPEALEALRNICNSPFRIVLVTNQSAVGRGLITLETALEINRRVVEHVQAAGGRIDGTWICPHSPEENCSCRKPKPGLLLQAASAMNLNLSHSFMVGDALSDLQAGWAAGVREAILVRTGRGTHQSRLPQVADLPPFHTFDTLAEALIHICSQVSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ5</accession>
    <name>E8MXJ5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64076">
        <property type="protein sequence ID" value="BAJ64076"/>
        <property type="gene ID" value="ANT_20500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20500"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051820_1_0_0"/>
    <dbReference type="OMA" id="YVYETRE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="35"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="320" mass="36374" checksum="623A0530642B5994" modified="2011-04-05" version="1">MNRFASPQVLKEALLAQKYLASDELSTVVYLSLQLEKPILAEGPAGVGKTELAKVLAGAMDRELIRLQCYEGLDETKALYEWEYAKQLLYTQLLREKLSQSLSDTSSLREAADRLAREEDVFFSMRFLLQRPLLKAILSEKPVILLIDEIDRADAEFEAFLLEVLSDFQVSIPELGTLKAVNRPVVVLTSNNTRELSEALKRRCLYLYIDYPTLEQELQVIRLKVPELSPKLARQAVELVQRLRTMDLRKSPSVSETLDWAKALVALNANALDQQTLETTLSVLLKHEADLQRARQQFFSPPPKDRRSGTDAFPSAPWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK9</accession>
    <name>E8MXK9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560460.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64090">
        <property type="protein sequence ID" value="BAJ64090"/>
        <property type="gene ID" value="ANT_20640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20640"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033160_3_1_0"/>
    <dbReference type="OMA" id="PRATMEE"/>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="413" mass="45331" checksum="8A84D22792FE7977" modified="2011-04-05" version="1">MPSQEKVRVLIVDDISETRENIRRMLQFDANIEVIGTARTGREAIEQAQQLKPDVIVMDINMPDMDGITATQEIKRKIPFIQVVILSVQGDQSYMRRAMLAGARDFLTKPPMIDELTDAIRRAGVLAHEERKKVTPGFPVAPVEPGLSTPMPALLPRGKVIVVYSPKGGTGCTTIATNLAIALKADEETRVALIDANLEFGDVAVFLNEQGKNTVLDLAPRAEELDPEIVQSVMVNHRASGLDILAAPPRPEHASKITGEQFSKMVEYLKSLYAYIVIDTASSLTEVVQAALDIANVIVLVTTQDIPSIKNCNLFLGLADAVGMKRDRILFIMNRYDKRINITPERVGESLRQPVATAIPYDDRFIPASVNRGIPFMLDNKAQAIAKSIQSLGDLVKEKIAKLEAAEAELSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN6</accession>
    <name>E8MXN6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">miaA</name>
        <name evidence="10" type="ordered locus">ANT_20910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560487.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20910"/>
    <dbReference type="EnsemblBacteria" id="BAJ64117">
        <property type="protein sequence ID" value="BAJ64117"/>
        <property type="gene ID" value="ANT_20910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20910"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_0"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="323" mass="36910" checksum="ED65CAF027044EB4" modified="2011-04-05" version="1">MSISKTRLQNNPLLVIVGPTAVGKTQVSIELARRLDAEIVSADSRLFYRGMDIGTAKPTPAERQGIPHHLIDVADPDEVWSLALFQQAAHQAIGAIHARGKLPILVGGTGQYVKAVIEGWQPPEQPPIPSLRAVLERMAAEQGKDAMHAMLTFLDPIAAQKIDPRNVRRTIRALEVIFSTGRRFSDQRRKTSSPYQVQIIGLTRNRKILYERVDARIEQMLQQGFLDEVRRLLEKYPPDLPAFSAIGYRQMIEVVQGKRTLEEAVAEIKRLTRRYVRQQGAWFREEDPQIHWFDLDQISFEEIFTFVYSWWKEVSQNESSMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ1</accession>
    <name>E8MXQ1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21060"/>
    <dbReference type="EnsemblBacteria" id="BAJ64132">
        <property type="protein sequence ID" value="BAJ64132"/>
        <property type="gene ID" value="ANT_21060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21060"/>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_3_0"/>
    <dbReference type="OMA" id="PGVPYEM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="31"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="407" mass="44639" checksum="886361D4EA0B8001" modified="2011-04-05" version="1">MCTGSADVELAKRCSIHYNRKNKREPMPVAEIVTIGTELLLGEILDTNTRFLARELRNLGVDLYRTTTVGDNEERIAGVLKEALGRSQIVLTTGGLGPTVDDPTRQAVARALGVKLEFHPELWQQIQERFQRYGRQPSENNRRQAFIPQGAIPIPNPVGTAPAFIGETSEACIICLPGVPREMEYLFQHAVVPYLKERFHLHGVIQVRVLHTAGVGESQIDEWIGDLETSSNPTVGLLAHPGQCDIRITAKAETPENAASMIADMEALVRQRCGEAIFGADADTLETVIAGQLSRLGWKLLVVEVGLEGELCARLRHPSLADVSTCRAETIAEEGSPLVPEKTDEAQVFLGVCLSRDFDSFSLRWEIVSPQGRQTGLRKFGGAPALVKTWAGNTALDLVRRHLSQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR8</accession>
    <name>E8MXR8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560519.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64149">
        <property type="protein sequence ID" value="BAJ64149"/>
        <property type="gene ID" value="ANT_21230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21230"/>
    <dbReference type="eggNOG" id="COG4712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096421_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="257" mass="28411" checksum="9441F9FDF12AC4C3" modified="2011-04-05" version="1">MSQQFDFSQILDALQEPFPSHEVEFKPGATNREKTKALALAYVDSRPYIQRLNLVCPDWQDEYQVMMQPDRVVVLCRLTIAGVTRTGDGECLLAGEEGDRAEPNAVTTASAQAFKRACVKFGLGAYLYDLPQVWCDYDAQKRKIINPPQLPEWALPPAERLEKATSRAVEREARLEGRGEMSAEPEPAGEPANLSNPGEFVMPGGKYQGKTLAEIAKTKDGQDYLHWFANLDGKGYQGKGAGEAQRMARAFLAIQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU6</accession>
    <name>E8MXU6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64177">
        <property type="protein sequence ID" value="BAJ64177"/>
        <property type="gene ID" value="ANT_21510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21510"/>
    <dbReference type="HOGENOM" id="CLU_3179508_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="46" mass="5146" checksum="9405F762B6405DB8" modified="2011-04-05" version="1">MSDWKTDKQTFETLTLSIACFIWVVLTLLLSAAYVVLVVLNAGGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC0</accession>
    <name>E8MYC0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_00310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558463.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00310"/>
    <dbReference type="EnsemblBacteria" id="BAJ62065">
        <property type="protein sequence ID" value="BAJ62065"/>
        <property type="gene ID" value="ANT_00310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00310"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573281_0_0_0"/>
    <dbReference type="OrthoDB" id="2159245at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="188"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="463" mass="50512" checksum="AF6D73CA77AC7866" modified="2011-04-05" version="1">MNAPLIWILFPLFFAFILWLVRWREGWVMRLGVVLCLLLALLAWLLPIGTGFRVFGNRWEIEPTLALAGRQLVVQNNDRPLLIFVYLIAAFWFGGSREARAHRFMIPYGLAVAALLLAALSVQPFLYAALLVELAVLLSIPLVAPPGKPVGTGALRYLIFQTFAMPFILLAGWALSAVEANPANTFFPLLAQIFLGVGFALWLAVFPFYAWMPLVAEEADPYPLGYLLMLLPTTFLLLGVRYINAVAWLKDLSALWEVLRLTGVVMILTAGGWAVFQRHLGRLFAYAVTIETGTSLLALSLNTPQSMETFAMLFLPRVLALALWALSASVMRSGGKGLRFEDLDRAAETFPFASAGLATAYLSLAGLPLLAGFPARFLLLEELATRAPLSAVLALAGTGGLLLSGFRVLAVLTGGYFGPREPRETPFQAILISVGVVVLILLGFLPRLLFPAMLGLVPAILMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC4</accession>
    <name>E8MYC4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558467.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00350"/>
    <dbReference type="EnsemblBacteria" id="BAJ62069">
        <property type="protein sequence ID" value="BAJ62069"/>
        <property type="gene ID" value="ANT_00350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00350"/>
    <dbReference type="eggNOG" id="ENOG502ZASA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052504_0_0_0"/>
    <dbReference type="OMA" id="PMEASIT"/>
    <dbReference type="OrthoDB" id="1506220at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="251" mass="26571" checksum="B5164373AAFB11CE" modified="2011-04-05" version="1">MIWLESILGLGLVLLAGALTLILSLPALRKRKVVLRTIPALQRARRALGLSVEDGSRIHLSIGKASIFSPTNASALVGLSTLERVAQLSLVSDRPPVATSGEGTLTVLSQDTLQAAYRIANVPEQYDPERGRLTGATPMSYTAAALPVIHQERISANLFVGNFGPEVGLMASASEHENAFSLGASDALDAQSVLYVTAEETLIGEELFAVPAYLQAGSIYQTSLRVQDILRWVVIGLMVLSAILGLAGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC7</accession>
    <name>E8MYC7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558470.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00380"/>
    <dbReference type="EnsemblBacteria" id="BAJ62072">
        <property type="protein sequence ID" value="BAJ62072"/>
        <property type="gene ID" value="ANT_00380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00380"/>
    <dbReference type="eggNOG" id="ENOG5031DS7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1282425_0_0_0"/>
    <dbReference type="OMA" id="WLIMVAF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="23014" checksum="9AF2F61182475149" modified="2011-04-05" version="1">MMEWVWMIVGVVLTLMVFSYIFGDNFLFRVATYLFVGVAAGYVFVVVFYQVLMPRLIEPIFLGTMAERVLAVVPLLGAALLLFKVSPRLAFLGKAPMAFLVGVGAAVAIGGSVFGTLLGQVSAAGAPFRSGSGILEGLLALIGAVGVLAYFQFSAPARASLSGEVPKRPAWMEALAWVGQVFLGITLGALFSGVLIASITALLDRVQAILLLLARLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD8</accession>
    <name>E8MYD8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558481.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00490"/>
    <dbReference type="EnsemblBacteria" id="BAJ62083">
        <property type="protein sequence ID" value="BAJ62083"/>
        <property type="gene ID" value="ANT_00490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00490"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513616_0_0_0"/>
    <dbReference type="OMA" id="MITRRIH"/>
    <dbReference type="OrthoDB" id="600220at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="1">
        <location>
            <begin position="146"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="557" mass="61834" checksum="EE2BBC661A686265" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE5</accession>
    <name>E8MYE5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_00560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62090">
        <property type="protein sequence ID" value="BAJ62090"/>
        <property type="gene ID" value="ANT_00560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00560"/>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_1_2_0"/>
    <dbReference type="OMA" id="MIFVVIE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="270" mass="28412" checksum="2402D9E932267B23" modified="2011-04-05" version="1">MMEWFAQQAPVLQALMGTLFTWGVTALGSAMVFFFKSINRRVLDTMLGFAAGVMIAASFWSLLAPAIDLAQENGQPGWLPAVAGFLAGGAFLWLVDRILPHLHLGLPLEEAEGIKTSWQRSILLVLAITLHNFPEGLAVGVAFGAVAAGIPSATLAGALALALGIGLQNFPEGAAVSVPLRREGFSRFKAFLYGQASGLVEPVAGVLGAVAVLLMRPLLPYALAFAAGAMIYVVVEELIPEAQQEKDTHAATFGAMLGFAVMMFLDVSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF5</accession>
    <name>E8MYF5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative prephenate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.12" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00660"/>
    <dbReference type="EnsemblBacteria" id="BAJ62100">
        <property type="protein sequence ID" value="BAJ62100"/>
        <property type="gene ID" value="ANT_00660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00660"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846336_0_0_0"/>
    <dbReference type="OMA" id="ACEGASM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="35773" checksum="EA2E120F738E0B83" modified="2011-04-05" version="1">MSVQITLIGLNQIGASFGLALANAAEQIHRVGHDKDPDMARMAQKMGAVDKLVFTLPAAVENADVVILSLPADELRFTLEAIAPYLKPGCTVVDTSPIPATSTVWAQKVLPREDRYFVTLTPTVSAKYLLESDRGTASAQADLFKDTMMMITAPAGTDSSALTLAESLAEMLGAKPIFSDAVEVSGLLASSHLLPELLSAALVNATAGQPGWSDIRKIAGQMYARMTEPAFFFEEKGKLGQNQIVSHEVLVAVLDHFIRELVEMRDAIARQDGEALHARFEQARQARQSWWSQRLKNQYPEASEQKSPGMPRFGESIGRLLGIRPKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI9</accession>
    <name>E8MYI9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_22990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560692.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22990"/>
    <dbReference type="EnsemblBacteria" id="BAJ64325">
        <property type="protein sequence ID" value="BAJ64325"/>
        <property type="gene ID" value="ANT_22990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22990"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036573_0_0_0"/>
    <dbReference type="OMA" id="VIACDQF"/>
    <dbReference type="OrthoDB" id="1111951at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="438" mass="49126" checksum="7D67BC3B3E13A8CC" modified="2011-04-05" version="1">MRTYPDLGIQIGEILLPREGIDLKKWAVIACDQYTSEPEYWEQVARLVGDSPSTFHLILPEVFLGTPEEQARIQSTQQTMRRYLNEGVFTSHNGLILVERQSSGRTRHGLMLALDLEKYDYSAGSQTLIRATEGTILDRLPPRMRIREGAPLELPHILVLIDDPQQTVIEPLMEVRKQFTRLYDTDLMFDSGHLTAWAVPDGGYEERVISALRALANPETFRARYGVGEDKGVLLFAMGDGNHSLATAKAIWEKIKGQVGMNHPARYALVEIENVHDHGLEFEPIHRVLFQCKESPSEALKKFFGDTVQITPVENAQLMIERVKKPSGDLQMAGMVTSEGYALVTFTQPTSNLPVGTLQGFLDTWLKAGGAEKIDYVHGDDVVVRLGAQPGNAGFYLPAMSKHDLFKTVILDGVLPRKTFSMGEARDKRFYMEARRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ7</accession>
    <name>E8MYJ7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560700.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23070"/>
    <dbReference type="EnsemblBacteria" id="BAJ64333">
        <property type="protein sequence ID" value="BAJ64333"/>
        <property type="gene ID" value="ANT_23070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23070"/>
    <dbReference type="eggNOG" id="COG3689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070027_2_0_0"/>
    <dbReference type="OMA" id="YPEPDAY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40047">
        <property type="entry name" value="PTHR40047"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09323">
        <property type="entry name" value="DUF1980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="251" mass="27871" checksum="A00D35E7C69211D2" modified="2011-04-05" version="1">MKERATRSFQALVMAGLGVFLLYQVSSGGITFYIHQRFVWLVGIGALLLLVIAQTLFQSRVSDDGHLEHEHSEAEEEHQHTSTPGWVLWLMILPVMMGILLPQRGLSASVIQNRGIQTAGTLSSTTQVVQVQEIPPEQRTVLDWVRLFSQPDQRTRILGQPVDVIGFVYRDPRLPEGQFMVVRFTLTCCVADASALGLAVSWANADSLAENRWVRVRGTLDATTLDGSPVPLVLAKQVDEVPEPAQPYLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM6</accession>
    <name>E8MYM6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">murD</name>
        <name evidence="11" type="ordered locus">ANT_23360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="9"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
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        <property type="protein sequence ID" value="BAJ64362"/>
        <property type="gene ID" value="ANT_23360"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell wall organization"/>
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    </dbReference>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mur-like_cat_sf"/>
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        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
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        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="115"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="460" mass="50532" checksum="54E857E98B7017BE" modified="2011-04-05" version="1">MTKNWKDSRVLILGAARQGQALARFLCQRGAAVTLNDQNPAEKLTLAMEVLAEYPIEWVTGGHPLELLERHDLLCLSGGVPETLPIVQEALRRGMPITNDSQIFMEEVPCRVIGITGSAGKTTTTTLVGRMASRAVVAPQKAWVGGNIGVPLIDRLDEIQPADVVVLELSSFQLQWITRSPQVAAVLNITPNHLDRHGTMEAYTAAKARILEFQSATDIAVLGREDAGAWGLREKVRGDLISFGLNHPAEGKGTFYDNGWLWYQGEMVEEALFERGKIALRGTHNLLNVLAACAIGIAAGFPPEALLDGVQGFGGVPHRLELVREWRGVRWYNDSIATAPERTIAAIRSFEEPLVLMLGGRDKKLPWDSLADLIHERVDHVVVFGEAAEKIAHAIGEVRPGKRPFTLTLCKTVQEAVQAAAAVAEEGDVVLFSPGGTSYDEFRDFEERGERFRKWVQELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ4</accession>
    <name>E8MYQ4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate/guanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ64390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560756.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64390">
        <property type="protein sequence ID" value="BAJ64390"/>
        <property type="gene ID" value="ANT_23640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23640"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477063_0_0_0"/>
    <dbReference type="OMA" id="CIMAAWG"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
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        <property type="entry name" value="GAF"/>
    </dbReference>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
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    </dbReference>
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        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="392"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="571" mass="63314" checksum="20EC28AC7558BC46" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS9</accession>
    <name>E8MYS9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560781.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23890"/>
    <dbReference type="EnsemblBacteria" id="BAJ64415">
        <property type="protein sequence ID" value="BAJ64415"/>
        <property type="gene ID" value="ANT_23890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23890"/>
    <dbReference type="HOGENOM" id="CLU_2766839_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="69" mass="8311" checksum="CC4847AB45A0EBFA" modified="2011-04-05" version="1">MKRCPHRRTIVASTGGYHYSYSAGVWDDIKEYVICLDCFKVIERGWWSWKYRVMRYYNVPPAKAEEVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ19</accession>
    <name>E8MZ19_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MvaI_BcnI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558560.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01280"/>
    <dbReference type="REBASE" id="32148">
        <property type="entry name" value="AthUNI1ORF1290P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62162">
        <property type="protein sequence ID" value="BAJ62162"/>
        <property type="gene ID" value="ANT_01280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01280"/>
    <dbReference type="eggNOG" id="ENOG502Z9I9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141953_0_0_0"/>
    <dbReference type="OMA" id="HGTKFRM"/>
    <dbReference type="OrthoDB" id="1158785at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.210.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029127">
        <property type="entry name" value="MvaI_BcnI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043004">
        <property type="entry name" value="MvaI_BcnI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043005">
        <property type="entry name" value="MvaI_BcnI_rec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15515">
        <property type="entry name" value="MvaI_BcnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MvaI_BcnI" evidence="1">
        <location>
            <begin position="10"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="267" mass="31089" checksum="990CBCEF479603FB" modified="2011-04-05" version="1">MITFTKEDLIEKIHQISREGWKKSVKQTIERRNDGAVGNTLECLLGLSENNLPIPNAQEWELKGQREHTSSLITLKHLEPSPTALQIVSCILLPNFGWRHKEAGKKYPNDEKSFRSTTDAIHYTNRGFKLVLDRNARKLRFTFSKDHIDASDPSIKEWANSVPDSLCPEPYWGFQDLEYAIGSKIKNCFYVIAESKIENRHEFFLYKKLFVLSGFDFERFLNCIEMGLVFVDFDARTGHNHGTKFRIKQNSWKNLYKSVQEINLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ52</accession>
    <name>E8MZ52_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558593.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62195">
        <property type="protein sequence ID" value="BAJ62195"/>
        <property type="gene ID" value="ANT_01610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01610"/>
    <dbReference type="HOGENOM" id="CLU_1238096_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="223" mass="25577" checksum="39C211C69CFD2285" modified="2011-04-05" version="1">MIRLGWLKHRNIPFEVPAEPLMYMLAVGYVGESQNASAFFRWFYNKVAEDDRRLVVYHENKSSAVKGDWDWAYQHPTFYTEVLGEEALEETLNDLSESGNVRGYDPFMDEPDFEDIDVVDSYAMTVLSPAETTLWQSTYVSDCSLMQLITPASFALSGSDLFRKDKEEDIGGFDVLFIEPFDMPSASLVRLSPRVPFVLPNQLQAGEYLLYYFGQWDVLVTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA4</accession>
    <name>E8MZA4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62247">
        <property type="protein sequence ID" value="BAJ62247"/>
        <property type="gene ID" value="ANT_02130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02130"/>
    <dbReference type="HOGENOM" id="CLU_1406193_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021224">
        <property type="entry name" value="DUF2690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10901">
        <property type="entry name" value="DUF2690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="193" mass="21105" checksum="543C6A188D657651" modified="2011-04-05" version="1">MKVERFDGRLNMSTLVSLFADSRKVRLVVFALMLVLFILGAGAPEDAGGVFQKGYKSVSHSHFTNILSDPEINTGAQGVNCSGSACNNTDPGTTGCNVDAATIHRKVFTNTKVQLRFSDTCQTRWSKTINKASINFYGNATLRYYYYGAVYLGPGYSVYSNQRFGMGYQACGKVGASPMNYLINDTDKCTAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC2</accession>
    <name>E8MZC2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02310"/>
    <dbReference type="EnsemblBacteria" id="BAJ62265">
        <property type="protein sequence ID" value="BAJ62265"/>
        <property type="gene ID" value="ANT_02310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02310"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393803_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="195" mass="22087" checksum="662E8252ED703216" modified="2011-04-05" version="1">MKGEWKYTRAVNPRLLRSEPMRRCTLGECRAACCLYGVWLAVEERDDLLEHAALIAPHMPPALRDPTVWFRGEETADPYAPSGRVIHSNVLPAPEHYGGTACVFLREDHKCALQVAGEAAGFHPWRFKPFYCILHPLDLDEQGRITLDETPAMLAEEGSCLRPSETLIPLMRTFEPELIHLLGDLPEQNSSDERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD5</accession>
    <name>E8MZD5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRISPR_Cas6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_24570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560838.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64483">
        <property type="protein sequence ID" value="BAJ64483"/>
        <property type="gene ID" value="ANT_24570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24570"/>
    <dbReference type="eggNOG" id="COG1583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063836_1_0_0"/>
    <dbReference type="OMA" id="CWWRISL"/>
    <dbReference type="OrthoDB" id="1403079at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="5">
        <location>
            <begin position="156"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="31799" checksum="27B09CE1CEC53D10" modified="2011-04-05" version="1">MSAATPLLSLVLTLRPLDFRRPAETLPHWWGRAAHALLLDTVRRTDAALAKSLHDDNALKPFTASNLMGRFSEGKLDPQQTYTLRFTSLIPELSRILLESFLPNGEVQLDYQMFRIEQVARTPEEHPWAGSAAWEELAGKSLLGRSAPSRRISLLFASPTTFRVDGRLIPLPLPDLVFNSLLQRWNSYAPLAFPDEVRRYAAECLQVSSYRLNSAAVRTQEEALRIGAVGQVTYTSAPYDRYWMSLIRTLAGFALYAGVGASTPMGLGQVRLIDPDKTPEESTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD8</accession>
    <name>E8MZD8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase WecB/TagA/CpsF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560841.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24600"/>
    <dbReference type="EnsemblBacteria" id="BAJ64486">
        <property type="protein sequence ID" value="BAJ64486"/>
        <property type="gene ID" value="ANT_24600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24600"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_2_1_0"/>
    <dbReference type="OMA" id="NMNGTDF"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="29637" checksum="E92D339D08285A7F" modified="2011-04-05" version="1">MNAPESLSSFNLLGVRVSVLNMPLALHTLERWIEHGERQYVCVANVHTVTESTRHPDLRRAMNHAGMVTPDGMPLVWMGLWWGHSSIARVYGPELLRQACRFGVPRGWRHYFYGGAPGVAERLVERLSRENPGLQVAGVESPPFRPLTEREEEELVERVQVAAPHLFWVGLGAPKQELWMAEHAGKLPVPVMLGVGAAFDFLAGLKPQAPAWMQRAGLEWLFRLMSEPKRLWRRYLVNNPRFIWLALSQMLGWWRPPDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE2</accession>
    <name>E8MZE2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560845.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64490">
        <property type="protein sequence ID" value="BAJ64490"/>
        <property type="gene ID" value="ANT_24640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24640"/>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562166_0_0_0"/>
    <dbReference type="OMA" id="DKNWLPH"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="217"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="498" mass="56673" checksum="F1962988BFB068A1" modified="2011-04-05" version="1">MSVSYRVAIWKGEARYPTLSPFHPSITYPEYRGHDLSQEENPAYEGVRESFRLLGMDAGRFNTPEWNPLGEIIHPGDRVLIKPNFVLSHHADGGNLFSIVTHSSVIRAVLDYVVLALKGEGSVVISDAPQMDCDFSTLSEQMGLSILQDWFWHAYKMPLEIVDLRSFWQKEMRDGVAYSHLRMPLPGDPLGEQWVNLGKRSAFYGVTDSSRFYGADYDRNEVIRHHHGEVQEYALSRTVLSADVVISIPKLKVHKKVGVTLNAKGLVGICTNKNTLVHYQVGFPEQGGDQFPPDFLSPMEKLSIRAQRWLFDHLLARQNPLFNRVYGLLRSVYRKTLRPVVTGESEAKKRIFDGGNWYGNDSAWRMTADLTQMFYHVDAHGNWCDLPPRRMFSIVDGIIGGDREGPLTPRARPAGVLIAGEDLLAVDWVATRLMGLNPQRLRWIEWLQTHGFADHFSEISLITEVPEWLDLLSKPGRYLEFEPHPGWKNYLELDDSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF6</accession>
    <name>E8MZF6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560859.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24780"/>
    <dbReference type="EnsemblBacteria" id="BAJ64504">
        <property type="protein sequence ID" value="BAJ64504"/>
        <property type="gene ID" value="ANT_24780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24780"/>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_1_0_0"/>
    <dbReference type="OMA" id="EKCTWCY"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="240" mass="27213" checksum="473979A9B1C97457" modified="2011-04-05" version="1">MAEEKQTGRWGMVIDLDVCTGCNACVTACAMENNIPWVGEEDAGYGRGMHWIRVQRYWEGEYPEVSPHYQPVMCQQCGRAPCEPVCPVFATVHSEEQQINLQVYNRCIGTRYCANNCPYIARSFNWFDYSQQIPTPMNYYLNPNVTVRRRGVMEKCTFCVQRIYEGQERAKAEGRVVQDGEIVPACAQACPTDAIIFGDLSDPESRVSKAARNQRRYTLLEELGTEPKVTYLKGEGTYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG0</accession>
    <name>E8MZG0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 23S rRNA (Uracil-5-)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_24820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560863.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24820"/>
    <dbReference type="EnsemblBacteria" id="BAJ64508">
        <property type="protein sequence ID" value="BAJ64508"/>
        <property type="gene ID" value="ANT_24820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24820"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_0_0"/>
    <dbReference type="OMA" id="SIIHVMN"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="409" mass="45124" checksum="14C2F3038DFA33E3" modified="2011-04-05" version="1">MSEFHLVDLTQMTYGGEAMGRLSDGRAVFVPFALAGERVLVQLTEEKRGFARATLMDVVQPSPARIRPRCPHFTQCGGCHYQHMDYDLQLTVKQSILTEQLQRIGGLTDPPIGLMVPSPRAWNYRNTVQFHLTPEGQLGFRATDDRTVIGIQECHLPEEPLLDLWKQIQAEPLPDLERLSLRLGADGEILLVLESLEDTPPAISVEELPVSVVHSGPAGSLVLAGDDHVIMEVLGRPFRVSAGSFFQVNTPMAEAMVKHVLSLLPAERLGTVLDVYCGVGLFSAFLAPRTQNLIGIESAPSACDDFAVNLDEFDNVSLYMGTAEQILPSLQVYPDLIVVDPPRAGLELAALDAILRMNAPTLIYISCDPATLARDTKRLIRGGYRLVQVTPFDLFPQTYHIESISLFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N011</accession>
    <name>E8N011_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-asparaginase II family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558743.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62346">
        <property type="protein sequence ID" value="BAJ62346"/>
        <property type="gene ID" value="ANT_03120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03120"/>
    <dbReference type="eggNOG" id="COG4448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062004_0_0_0"/>
    <dbReference type="OMA" id="DDCGAPT"/>
    <dbReference type="OrthoDB" id="1434447at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="343" mass="36656" checksum="A996D02ADBE1E571" modified="2011-04-05" version="1">MNPYQPLVELTRGPLVESIHFGALAVVDSTGNLIASVGDPHHVANLRSSAKPFQALPLVESGVVDAFGITPRELAIICASHSGTEDHVAVLRGLQAKIGVSEDNLLCGTHYPLHEPTAQALRARGEAPTQNRHNCSGKHTGMLAGCQFNRFALEDYLNTEHPWQKRILQTFAQMVSLAPEDVPIGIDGCSAPTFAAPLQNAAHAYALLADPASLPEPRRSALNRIFHAMTTYPDMVAGPERFDTVLMQVTGGKVVAKGGAEGYQGMGVRPGALGPGSPGLGIAIKISDGDTGGRAVTLAAVQVLRLLGVLTAEELAGLTKFDRRPLYNWRKLEIGEIRPCFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N022</accession>
    <name>E8N022_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558754.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62357">
        <property type="protein sequence ID" value="BAJ62357"/>
        <property type="gene ID" value="ANT_03230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03230"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_6_0_0"/>
    <dbReference type="OMA" id="AKNLQPW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="193" mass="21541" checksum="203414CAD887518B" modified="2011-04-05" version="1">METLEVIRNRCSLKEQISPREIEPGILYTVLDAARYAASSRNHQPWRFVVVQGQPAVQALVDAAVTGTNAVIRNAPVVIAVCARPQDDSISNGREYYLFDTGMAVANLLLAATDFGLVTHPMAGFDEAALKRHLHIPEDVRVLMITPLAYPASESYDEAARERLSQRSRKAFEEVVFFNRWGEIQPEMDAIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N029</accession>
    <name>E8N029_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558761.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03300"/>
    <dbReference type="EnsemblBacteria" id="BAJ62364">
        <property type="protein sequence ID" value="BAJ62364"/>
        <property type="gene ID" value="ANT_03300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03300"/>
    <dbReference type="HOGENOM" id="CLU_2748938_0_0_0"/>
    <dbReference type="OrthoDB" id="2211731at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="70" mass="7784" checksum="F7B9E162CE0CE870" modified="2011-04-05" version="1">MNPHKVSFDPMKEGHPDPFSQPNTIPGGWDLTDAVLKTHPHARAADMNGTAYEQHLRFTAGGYERPQDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N081</accession>
    <name>E8N081_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558813.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03820"/>
    <dbReference type="EnsemblBacteria" id="BAJ62416">
        <property type="protein sequence ID" value="BAJ62416"/>
        <property type="gene ID" value="ANT_03820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03820"/>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747346_0_0_0"/>
    <dbReference type="OMA" id="KDNISWH"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="54"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="362" mass="41064" checksum="FA0D5DD20C974D30" modified="2011-04-05" version="1">MKSKVAVLRTRPETVLDDYRHLCALAGLREALDPGATTILKDNISWHLMYPSSNTTPWQLEGTILALHDAGFHDLVDVHNKTVVTIADLGDRYNKFGPVLEKYGIPKKYNFRDEDMRWVEIKPKAQMAVLHKIFPHGIYIPDFFIGKNIVHLPTVKTHSYTVTTGAMKNAFGGLLNVNRHYTHTWIHDTLVDLLAIQREIHTGIFATMDGTTAGSGPGPRTLIPHQKDVILASADQVAIDAVAAQMMGFDPMKIEYIAHATERGLGQGNPREIEIVGMPEVAEERWNFKVGVNLGTGTGRLLWHSPLKVFQKLFFHTPLVNIFIFASEYYHDHFWYPLYGKPVVERWKRESPWGQLFEQYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N085</accession>
    <name>E8N085_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_26080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560988.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26080"/>
    <dbReference type="EnsemblBacteria" id="BAJ64634">
        <property type="protein sequence ID" value="BAJ64634"/>
        <property type="gene ID" value="ANT_26080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26080"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773036_0_0_0"/>
    <dbReference type="OrthoDB" id="1885409at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="60"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="358" mass="41128" checksum="501E2149B13D6EBC" modified="2011-04-05" version="1">MKDSLKKISFALVVFVLPIFTLLPYSPWVMKGLHRDSGVFLYVGQQILNGGLPYRDIWDHKPPVIYYVNALGLLFDNSRWGVWTIELVCLVISSLLAYQLIKKHFGDFVGLIVSTLWLLTLVFVLQGGNLTEEYALVFQFLLLVMFDRINGKNRSILYFSVGVFSGLMFCIKQTTIGIFLGIIVLTLYKMFGKRQLFLFKNIFLIILGWTLFPAFWVLYFYIHGGLPNLLEAFYYNFVYSSQNKDLLNRLAPLITGIEPLTETGFFQFGMIGYILLVMDIFLGKDNNKWLVNLLQLIAVTLPIEYVLVSLSGHTYKHYYITLLPMLSLSSAYFIKVIINYCSLVALLQSWLKCGKHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H0</accession>
    <name>E8N0H0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">feoB</name>
        <name evidence="13" type="ordered locus">ANT_26930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64719">
        <property type="protein sequence ID" value="BAJ64719"/>
        <property type="gene ID" value="ANT_26930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26930"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_6_0_0"/>
    <dbReference type="OMA" id="MEMPDYE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0410">Iron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="12">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ64719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="658" mass="71771" checksum="74B7B08ABC76436D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0K5</accession>
    <name>E8N0K5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27280"/>
    <dbReference type="EnsemblBacteria" id="BAJ64754">
        <property type="protein sequence ID" value="BAJ64754"/>
        <property type="gene ID" value="ANT_27280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27280"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_37_2_0"/>
    <dbReference type="OMA" id="TERCTHV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="103" mass="11650" checksum="8F2E326D09BCDB27" modified="2011-04-05" version="1">MGWQYLFPSERLSIDPRSGIVRRHHLDPSGLQRAVKAAAKLVGIDKPVSPHTFRHCFATHLLEAGYDIRTVQELLGHKDVKTTMIYTHVLNRGPKAVRSPLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L9</accession>
    <name>E8N0L9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561116.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64768">
        <property type="protein sequence ID" value="BAJ64768"/>
        <property type="gene ID" value="ANT_27420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27420"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_0_1_0"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="318" mass="34539" checksum="14B62919168680DD" modified="2011-04-05" version="1">MNATIDRKRISIFLAFAFGIAWFFGGLLYLLVVRPSGGQALTPVQQTLSFLLLAVGYMSAPALANVLTRIVTREGWSNLWLAPRFQKGWLYWVIAWVAPALLTLFGSAVFFLLFPQYYDPSMPIVQEQLQKSGVTLPFSTWALFWLQTVQAILIAPLINSIFTFGEEFGWRAYLLQKLLPLGKRRALLLLGVIWGIWHAPVIAQGHNYGMQYAGYPWLGILAMTIFTIGAGCFLGWATLKAGSVWPAVIGHAAINGIAGLGMLLSTGSPNPVLGPSVAGLLGGMGFLLAGLAVLVIPWKASLPEETTAPDIHPPSTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0M0</accession>
    <name>E8N0M0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_27430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561117.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27430"/>
    <dbReference type="EnsemblBacteria" id="BAJ64769">
        <property type="protein sequence ID" value="BAJ64769"/>
        <property type="gene ID" value="ANT_27430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27430"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_3_3_0"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="111" mass="12357" checksum="63D2BA8E55B3E4F3" modified="2011-04-05" version="1">MEIEHTQYKHCDLVKARGRIDSYTAPQLSEALNKITESGRYKIALDLSGVEFMSSAGLRALINTQKVCKRYNRGELVLVSVPENIRAALDLAGFIPLFKIYDDVVTAIGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q4</accession>
    <name>E8N0Q4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62449">
        <property type="protein sequence ID" value="BAJ62449"/>
        <property type="gene ID" value="ANT_04150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04150"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_789031_0_0_0"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="40768" checksum="42F62C6EF360B10D" modified="2011-04-05" version="1">MLQHVQKTCPFFSALLCLCTTIKPVKVFIPVKTSSIRPLDVNRDMLAVAALIEECFASTLDPDGREYLYHIRRAVEDPALIRWVWTTDEEVSSPLFGYVWEEDGRIVGNLTLIPARKGKEWVYIIANVAVHPDYRRRGIARQLTLRALDHLRQHHIRSAWLQVREDNPAAHHLYLSVGFAERSRRALWLSSLPGVRPPHVPGVRVTGRRWRDWKCQREWLQRTYPSDVRWNLSLSISRFNANPFYQFVQWMMGSNQRHWVARGVGADRKPWGFLSWEHLTSYIQMLWAATNPAHEEEALMALLPRAQQELAHLHLPLGVNYPASKAEAAFQACGFHLHSVLIWMEYRLEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S5</accession>
    <name>E8N0S5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558866.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62470">
        <property type="protein sequence ID" value="BAJ62470"/>
        <property type="gene ID" value="ANT_04360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04360"/>
    <dbReference type="HOGENOM" id="CLU_843701_0_0_0"/>
    <dbReference type="OMA" id="IHRQPFI"/>
    <dbReference type="OrthoDB" id="2164905at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="36950" checksum="049AC03BD80B95B9" modified="2011-04-05" version="1">MASSTRTEIAPPRLMASIHAGFNLVANRAYLLAFPILLDLFFWLGPRYRVKALFSPFIEDWLSMTQAMGGAQVSDMIDTVRKFWEMQLDRFNLFSALSTFPIGIPSLMAGLMPEKTPLGMPSIMEIQSFGQFVSGFLLFSLLGLVLGCVYFSLLAREVRLFEEEHGTLRLLIWEVGQVFLLVVSLILLALVISVPLLGMAAILEMISLQFLQIFTLVVMVALLWIIVPLVFTPHGIFVARRNFLTSALLSVRTWRWLFPSIGLFLLSLLLISQGLGYLWRIPPEDSWLMLAGILGNAVVSTALLGASFVYYRDALLWAEALRRATQVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V5</accession>
    <name>E8N0V5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558896.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04660"/>
    <dbReference type="EnsemblBacteria" id="BAJ62500">
        <property type="protein sequence ID" value="BAJ62500"/>
        <property type="gene ID" value="ANT_04660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04660"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_1_0"/>
    <dbReference type="OMA" id="PLRMWTY"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="316" mass="35625" checksum="9456B0C23A6EBF4F" modified="2011-04-05" version="1">MKPVFSIIAPIFNEHDSLPELHRRVSAVMDGLGEPWELILVDDGSSDGSTDLIRQLAEQDERVRPVIFARNFGHQIAVTAGLDYARGDAVVIIDADLQDPPEVIPDLVARWREGYEVVYAVRTEREGESWFKLFTASLFYRIIFRITDVKIPMDTGDFRLLDRKVVNVLKTMRERHRFLRGMAAWVGFRQIGVPYKRAARFAGSTKYPFKKMLRLALTAITGFSYFPLQVATYLGFISAGLALIFIPIVVIERLVGNQAFFGQATTLVSVLFLGGVQLISLGILGEYIGRIYDEVKGRPLYIVREAPENDSSHPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W4</accession>
    <name>E8N0W4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558905.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04750"/>
    <dbReference type="EnsemblBacteria" id="BAJ62509">
        <property type="protein sequence ID" value="BAJ62509"/>
        <property type="gene ID" value="ANT_04750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04750"/>
    <dbReference type="HOGENOM" id="CLU_1507629_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228586" evidence="1">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="178" mass="19553" checksum="61DEBB0F3503EE3B" modified="2011-04-05" version="1">MKPPIKTMLLIALLMITLIFSWNAAQAQKGETPPSPQSETLDGNTRSLDSVSPQALTGFIITSNPYCYQPDVSRNECIINFRYTQANDDGTNAPLLKYLKYSIDGKMRYYSGKFFENSITYAYSMVPQGFKVPCGLPNESGLGNDFGKSYAIVIQAIGNTDTQLGANFFSVACPAYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z8</accession>
    <name>E8N0Z8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative M16C family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62543">
        <property type="protein sequence ID" value="BAJ62543"/>
        <property type="gene ID" value="ANT_05090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05090"/>
    <dbReference type="eggNOG" id="COG1026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_1_0_0"/>
    <dbReference type="OMA" id="MTYPDKT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M16C_associated" evidence="1">
        <location>
            <begin position="496"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1007" mass="114535" checksum="8703D478F461033C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N110</accession>
    <name>E8N110_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glgX</name>
        <name evidence="5" type="ordered locus">ANT_05210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558951.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62555">
        <property type="protein sequence ID" value="BAJ62555"/>
        <property type="gene ID" value="ANT_05210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05210"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_0"/>
    <dbReference type="OMA" id="SEPWDCG"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="157"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="689" mass="78296" checksum="29A190FD3BECBFC1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N142</accession>
    <name>E8N142_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="6">1.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sdhB</name>
        <name evidence="9" type="ordered locus">ANT_27590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a menaquinone + succinate = a menaquinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:27834"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="EC" id="1.3.5.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="6">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.4" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561133.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64785">
        <property type="protein sequence ID" value="BAJ64785"/>
        <property type="gene ID" value="ANT_27590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27590"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_0"/>
    <dbReference type="OMA" id="CPKGISL"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="249" mass="27331" checksum="0C6CDD72AF408A02" modified="2011-04-05" version="1">MSDEKWTVTFTVYRKKDEQPARYDTFTLEVSPDEYVLDAVERIWAFHDRSLVFAHACHHSTCGACGMRVNGVERLTCITPIREVTRNGGTVRVEPLRNFPVVSDLAVDMSRLYRAMDAVQAPAVHPLDAAPLEGGGIRPPREVPQPEDEGEFYRLADCIECGLCVSACPVAGTDPTYLGPAALAGAQLQGVAQNPDLLGVVDCAEGVWRCHSAYECTAVCPSNVQPGWRIMDLRRQVVAQRIKALFGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N166</accession>
    <name>E8N166_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M50 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_27830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64809">
        <property type="protein sequence ID" value="BAJ64809"/>
        <property type="gene ID" value="ANT_27830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27830"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028221_0_1_0"/>
    <dbReference type="OMA" id="GAIIRMR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="PTHR31412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="8">
        <location>
            <begin position="140"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="421" mass="46384" checksum="672480186E9512C9" modified="2011-04-05" version="1">MHSSIIESMDNGLSMDLDALITRVMSVEDKTLGSVEQGFVVRYRGRLMGEDTARLYDWLEDALRPYQLTPVFRMEDRRHVVYFIPAQPQPKPSSGRLNLILFILTLISVIYTGGAMSITQEPPPGFIPGLMAYLSAGWPFAVAILSIMGAHEFGHYLMGRYHNVHVSLPYFIPFPNVFGTLGAVINMKERVKNRRVLLDIGIAGPLSGLVVSLLVLGIGLSLSNLSTLPPAPPQLPSEGGFFQQFLDRLTAPVTLTLEGNSILYLLMKYLRFGMLLPAPADYGGVPPVLYWIRYFFTASPPPYGGVDVSLHPVAWAGWGGLLITALNLIPAGTLDGGHLINVLIGRKRAMRLLPWIQGILLAMSLLSINWLIWLLLISWLGKAYAEPLDEITPLDPPRKALAVLGIIIFFLVFTPVPISGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N171</accession>
    <name>E8N171_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SufE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27880"/>
    <dbReference type="EnsemblBacteria" id="BAJ64814">
        <property type="protein sequence ID" value="BAJ64814"/>
        <property type="gene ID" value="ANT_27880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27880"/>
    <dbReference type="eggNOG" id="COG2166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124502_2_0_0"/>
    <dbReference type="OMA" id="EQVVECQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="PTHR43597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufE" evidence="2">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="147" mass="16411" checksum="A9C9D2CF45E613E7" modified="2011-04-05" version="1">MMLPQRLAEIVEDFRLCQGREKLELLLQYAESLPTLPDHLKEHLNEMEAVPECMTPVSVMAEWQENGAIFHFAVPAESPTVRGYAAIIAEGLRGATPEEILNLPSDFYIAMGLQDVVTSQRLNGMAAIVAHVKRLALVRLEQMNKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N174</accession>
    <name>E8N174_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_27910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561164.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27910"/>
    <dbReference type="EnsemblBacteria" id="BAJ64817">
        <property type="protein sequence ID" value="BAJ64817"/>
        <property type="gene ID" value="ANT_27910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27910"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_0_0"/>
    <dbReference type="OMA" id="MIFGNWM"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="423" mass="44922" checksum="0E5D107BD408C4B5" modified="2011-04-05" version="1">MATSTIVIHRKVEIISPTRQRVTGIVEVLLGVLIFLFSRRAEPGMVARFVMTPGGLDRGAAPDWIVPAYATLLVLAILAVGLGLVQIFRGFGRWMNLVLSVVVALFVFAFLTWATAGKSLNLVGMLSAAVLLGVPIILGAFSGVLSERAGVVNIAIEGMMLMAAMVGALVGSVTKNMWIGLLAAVLSSMLLALIHGVLSIHYKINQIISGTVINIFSTGLTSFLSAKFLQTYQQLNNPPIFPRIPIPLLADIPVIGPLFFNTNLFVYIMLIALIVIQVALFSTRWGLRLRAVGEHPKAADTLGINVFATRYMAVLLSGLMAGIGGAFFTLGSVGRFDEMMTAGKGFIGLAAMIFGNWTPLGAFGAGLLFGFADSIATKLTILGTGIPTQFMAMSPYIVTMIVLAGVVGRGQMPAADGTPYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A8</accession>
    <name>E8N1A8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561197.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28250"/>
    <dbReference type="EnsemblBacteria" id="BAJ64851">
        <property type="protein sequence ID" value="BAJ64851"/>
        <property type="gene ID" value="ANT_28250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28250"/>
    <dbReference type="eggNOG" id="COG3832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_5_1_0"/>
    <dbReference type="OMA" id="CIRWTGP"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="149" mass="16658" checksum="595C00F784769D5E" modified="2011-04-05" version="1">MKIDSRAPLSAREEILISAPVEQVWSAMSEIDRWAEWQSDVTAAKLDGELKAGTTFHWKAKGLNIVSTIQVCEPMRRIGWTGNSPGMQAVHLWTFEPSAEGTLVTTEESLSGWFARLLKVLDAQFLQKSLLQSLQVLKEHVEGKQRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I0</accession>
    <name>E8N1I0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558981.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62585">
        <property type="protein sequence ID" value="BAJ62585"/>
        <property type="gene ID" value="ANT_05510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05510"/>
    <dbReference type="HOGENOM" id="CLU_1871101_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="14371" checksum="F382CECCE4AD3E46" modified="2011-04-05" version="1">MTEHENHLDQQRAEIRKVLIVIIVVAFACYCVGLSILQFNAWINRPTATPTVTPTITETPAVTVTPPQASPTLITLTATGTGTPTMTPSFTPTFFTFTPTVTATSTPTPPPPTATNTPVPPSPTETETPVAPTTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1L6</accession>
    <name>E8N1L6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_05870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559016.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05870"/>
    <dbReference type="EnsemblBacteria" id="BAJ62621">
        <property type="protein sequence ID" value="BAJ62621"/>
        <property type="gene ID" value="ANT_05870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05870"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313298_0_0_0"/>
    <dbReference type="OMA" id="YQGYRER"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="145"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="209" mass="23854" checksum="2BD6AA1F8BE12040" modified="2011-04-05" version="1">MSVPLGPILVVEDVPHVRELLEVTLRFKGYPVVSACDGLEALEFIARERPALIVADILMPRMDGFAMAHEIRKNPQTRSIPIIFVSATYVTPEDKKFALSFGGVRFIEKPIDTEDFLLTVAEVLTSDSPNVPAPMNERDFYQGYRERLEQKLRHKNTQISRTERLLATLPDEQKPAFETLLKQALADRDEIQRELDQLYKILDEMKGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M9</accession>
    <name>E8N1M9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Na(+)/H(+) antiporter subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mrpD</name>
        <name evidence="4" type="ordered locus">ANT_06000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559029.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06000"/>
    <dbReference type="EnsemblBacteria" id="BAJ62634">
        <property type="protein sequence ID" value="BAJ62634"/>
        <property type="gene ID" value="ANT_06000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06000"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_2_0"/>
    <dbReference type="OMA" id="YVAHHIT"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="127"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="493" mass="53291" checksum="C1E797FF85BE3B02" modified="2011-04-05" version="1">MNGLSIAPIVLALVWGILGLIFWQRTRVLRWLGVAGSTSFVALSIVLLLLVQKEQFLVIQVGAWRAPFGITITIDLLSALMVTMTSVLAWFIALFSLTEVDEAQARYGFYPLFFLLLMGVFGAFTTGDLFNLYVWFEVMLMASFVLMALGGHRAQLEGATKYVLLNLIGSTFFLIAAGLTYSMTGTLNMADLAVQIREVEHSTLPLVLSAIFLVAFGIKAAIFPLFFWLPASYHTPPIAVTALFSGLLTKVGVYAMLRVFTLIFPMNGTILQSILLILAGFTMVTGVLGAAAQWDLRRLLSFHIISQIGYLIMGLGLFTPLALAGTIFFTLHVVIAKAALFLVSGMIQRLTGTFNLKPLGNLAQTQPAMALLFAFPALSLAGLPPFSGFFAKLALVRAGLEVQQGAIVAVSLAVSLLTLFSMSKIWQEAFWKPAKREEKGALPANLWGAVSGIVLVSVLLGLLANPIMTLSLQAAHQLLQPSLYVQAVLGGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N1</accession>
    <name>E8N1N1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na(+)/H(+) antiporter subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mrpB</name>
        <name evidence="9" type="ordered locus">ANT_06020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559031.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06020"/>
    <dbReference type="EnsemblBacteria" id="BAJ62636">
        <property type="protein sequence ID" value="BAJ62636"/>
        <property type="gene ID" value="ANT_06020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06020"/>
    <dbReference type="eggNOG" id="COG2111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101659_1_1_0"/>
    <dbReference type="OMA" id="HPGFLMP"/>
    <dbReference type="OrthoDB" id="1962104at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007182">
        <property type="entry name" value="MnhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04039">
        <property type="entry name" value="MnhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="MnhB" evidence="8">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="139" mass="14817" checksum="2A984544D39906E8" modified="2011-04-05" version="1">MKARSMLLQVAVSYLMPLLLIFSIFLLIRGHNEVGGGFVGGLVAAASFILYAIAESPNAARALLPLSPDKLIALGLSIAVLSGLPAVFMGMPFMTGLWIKQPLPVIGKLGTPFIFDIGVYLVVIGVCLHILLNLAEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N8</accession>
    <name>E8N1N8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559038.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62643">
        <property type="protein sequence ID" value="BAJ62643"/>
        <property type="gene ID" value="ANT_06090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06090"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_793756_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228055" evidence="2">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="349" mass="37745" checksum="9749462401986C2A" modified="2011-04-05" version="1">MKKTLFLLALLGALFLSACASSVELGSLFTPTFTLTPSLTPSVTQTPTPTETLTPSPTDTETPTLSPTFTTSFTPTSTDTVTPGPSPTDTRTPTVTRTPTRTRIPTRTRIPTRTPTITLTPTITNTPTPPPPQTAILRPGLLSRVVSPIQAEINVTPGEDGMVRIELIGEDGRIIVRQVLDYRNYRGRSITIYPQIPFEIQAMAETARLQVVTQDRFGRTISLMSVDLVLLSLGRAEIYPPLVTQEPYIVRFPQEGQVVSGGVLWISGLARPVNSSPILIELVGESGAVLSTKLLTVEPPSGELSHTPFEVEIPYQVNASTPVRLTFRQEGGRIPGTVALSSRVIVLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S0</accession>
    <name>E8N1S0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559070.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62675">
        <property type="protein sequence ID" value="BAJ62675"/>
        <property type="gene ID" value="ANT_06410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06410"/>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567011_0_0_0"/>
    <dbReference type="OrthoDB" id="756259at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="481" mass="54944" checksum="8B6E9A1B0DAEE9AA" modified="2011-04-05" version="1">MTDKTIFISADHGLSIVYFLQTDVLPTLLESGARVVVLTDDGIRDQIAAKFSQPNLIIEGLRFRQCREYFEKNDHSLQYWMHFLRWMGGSNRINTNAMDGHLRQMAHEASPRGKRLMPLIRGLTYVLRRSRLARQALVNFQRRYTPNIYGDLFEKYQPSLVVASTPGWRWDRYLLREAAARGIPTAAVIVGWDNPSSYRLPGAPVDWITCWSEIQKQELVLGSDWKPERVHVGGIPSYDGYFRGTWKMSREEYFRLHGLDPNRKLLSYACSFVTFSPNFANIRALAELVHQDALAEPTQLLIRLHPNHFQPGSLYEQEANRVRELIRGMPHVHLVEPVPLGGELGYYSGEDMPEKASMMAYSDVFLTVYSTMVVETAIHDRPIVSVCIDEPGGWNTPGKFSLSLQEIGEWPTHLRFRAAGAGRVAYNAEQLKDILNLYLRAPETDSAQRRKFIQDECTFTDGSAGWRTGTFLRSLLERGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W4</accession>
    <name>E8N1W4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561256.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28850"/>
    <dbReference type="EnsemblBacteria" id="BAJ64911">
        <property type="protein sequence ID" value="BAJ64911"/>
        <property type="gene ID" value="ANT_28850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28850"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_3_0_0"/>
    <dbReference type="OMA" id="IYVYSFC"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="132" mass="14497" checksum="E5A91CB0EE6F8908" modified="2011-04-05" version="1">MEMIIDFPGGAKVDAHFGQFTVKTDQPPIGGGDGSAPAPFEVFLASIGTCAGIYVLGFCRQRGLPTDGIRIIQRAYRDFTTGLIGTIELEIQVPPTFPEKYHESLVRSANMCAVKKHLEHPPQFNTYTRVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z0</accession>
    <name>E8N1Z0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561281.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29110"/>
    <dbReference type="EnsemblBacteria" id="BAJ64937">
        <property type="protein sequence ID" value="BAJ64937"/>
        <property type="gene ID" value="ANT_29110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29110"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391726_0_0_0"/>
    <dbReference type="OMA" id="CLVSDYA"/>
    <dbReference type="OrthoDB" id="131906at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="630" mass="69894" checksum="30E5E875E5F03397" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N201</accession>
    <name>E8N201_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561292.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64948">
        <property type="protein sequence ID" value="BAJ64948"/>
        <property type="gene ID" value="ANT_29220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29220"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048237_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="29763" checksum="CF0CF58DAE90D5D7" modified="2011-04-05" version="1">MPETVAEFSPRLEGERLLRRWWMLVLCAFLGALMAFVYSLRTATEYEVSFSVLTGIDQTTAGELTQYEEDVMFEAVGYILYSPDTLAQIAALAQEQGIALTPADLRDSSSVERRLNEWRVRLHRPHPQEAETLGRLWMQWSWDELQRAYAHALTADGLRRYAESLTACLSRAVTTEPAYGLCGFARLPDLQAELAQTSQRLLEERLASRGLSSSLLLHEVQWETPAPRPVSYRRGWLVLSGLGLGLLAGLILVFALPERKHGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N212</accession>
    <name>E8N212_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rmlA</name>
        <name evidence="7" type="ordered locus">ANT_29330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561303.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29330"/>
    <dbReference type="EnsemblBacteria" id="BAJ64959">
        <property type="protein sequence ID" value="BAJ64959"/>
        <property type="gene ID" value="ANT_29330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29330"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_0"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="32496" checksum="A1C1080B7C25C453" modified="2011-04-05" version="1">MKGIILAGGKGTRLYPLTLSISKQILPVYNKPMIYYPLSILMFARIREILVISTPDDLPAFRRLLGDGSQWGLSFAYAEQPQPNGLAEAFLIGRDFLAGESAALILGDNIFYGHGLPEQVQRAASLTHGAVIFAYPVRDPERYGVVEFDGSGRAVSIEEKPKQPRSRFAVPGMYFYDERVCDFAAALKPSPRGELEITDLNRVYLERGELQVELLGRGIAWLDAGTHESLMQASSFVQAVEDRQGLMIACPEEIAWRMGFIDDEQLLAQARRYGQNEYGTYLLRLLEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N214</accession>
    <name>E8N214_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlC</name>
        <name evidence="4" type="ordered locus">ANT_29350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561305.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29350"/>
    <dbReference type="EnsemblBacteria" id="BAJ64961">
        <property type="protein sequence ID" value="BAJ64961"/>
        <property type="gene ID" value="ANT_29350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29350"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_1_1_0"/>
    <dbReference type="OMA" id="RGVFLEW"/>
    <dbReference type="OrthoDB" id="1618609at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="182" mass="20813" checksum="C990889D13C8DAD8" modified="2011-04-05" version="1">MHCLPTAIPEVMILEPQVFRDARGFFMETFHEEKFAALGLPTRFVQDNHSASRRGVLRGLHYQIQQAQGKLVRVISGEVFDVAVDLRRSSPTFGQWVGEVLSAENHRMMWIPAGFAHGFLVLSDWAEVLYKTTDFYAPQWERTLLWNDPAVGVRWLISPGEQPLLSEKDQRGLPLSQCETYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N275</accession>
    <name>E8N275_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29960"/>
    <dbReference type="EnsemblBacteria" id="BAJ65022">
        <property type="protein sequence ID" value="BAJ65022"/>
        <property type="gene ID" value="ANT_29960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29960"/>
    <dbReference type="eggNOG" id="ENOG50340JU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665455_0_0_0"/>
    <dbReference type="OMA" id="AVTRTCW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="408" mass="47443" checksum="69475B6308DBA00B" modified="2011-04-05" version="1">MKKPWMEDWGFAFDPFEHLEASQDVHLHRYLVGHRDWSAVLAEQPHVVFSPPGGGKTALRLYLYRTCWTGGQGQRPFALHYSLPDCWEFHTLASLAQLSEEELYQQHLSQMVRMGARSLFFGSCYFPVLFLHHCPPAQRAALAQFIDHVAPETRWYLEVIRETKNPNTAAVHAGNAFVLNHQPDFALLEAFLREWEKALKGEKSTAPFSSSLEAFEQELFLIREVLGFPGIFILMDGVDGMTAYQRLDARKVLKPLLRRIPEWGEQDIFLKAFLPEEVHEVLEEDLREVLNQFPPLFIRWQVSDLIELLQARIRVATGGAFDSFASVAAPPLCYEEVERILVSMLPEHRLLPREALTLVSELLNAYTQRMEHFHPLKRLEQEDVEWAGRRYRQQYEIFANRTEIQSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C9</accession>
    <name>E8N2C9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribose/galactose isomerase</fullName>
            <ecNumber evidence="2">5.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559129.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62735">
        <property type="protein sequence ID" value="BAJ62735"/>
        <property type="gene ID" value="ANT_07010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07010"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_0_0_0"/>
    <dbReference type="OMA" id="DDRVDYP"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="148" mass="16034" checksum="25B6ECC7102538D7" modified="2011-04-05" version="1">MRIAIGWDEHLPIVDRILSYLAEHGYEVQTFGPPAGEAWQWSAVARDAATAVARGDADEGILLCWTGTGVSIAANKVRGIRAALCADAETARGARKWNNANVLCLSMRLTSEPLAVEILDAWLSTAYQPNPQDDACLRVIEELDAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2E0</accession>
    <name>E8N2E0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abhydrolase_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559140.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62746">
        <property type="protein sequence ID" value="BAJ62746"/>
        <property type="gene ID" value="ANT_07120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07120"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_4_0_0"/>
    <dbReference type="OMA" id="QGSAWTT"/>
    <dbReference type="OrthoDB" id="1470522at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="54"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="299" mass="33304" checksum="AEBEE570FE1DFD66" modified="2011-04-05" version="1">MSTKPHYAVPFPIPEANTDHIKRKMFDLPYAHSSPAQKLDIYWPEEGNGPFPVVISIHGGAFMGGDKRDIQIKPMFEVLKYNYVLVGVNYRLSGEATFPALIHDIKAAIRWIRANARTYLFDPNRIATWGGSAGGYLSLMAGVTAGIRELDDPSLGNAAQPDHVQAVVSWFPPTDFLKMDEQLAESGFPPPPEYTHSGENSPESLLLGRKITDVPDLVRVANPETYIRPGLPPFFIQHGRLDETVPYQQSLHFANQLAAVNPQGVTYEILPEARHADSAFETPQNIQKVLNFLDKALRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2M0</accession>
    <name>E8N2M0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_07920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07920"/>
    <dbReference type="EnsemblBacteria" id="BAJ62826">
        <property type="protein sequence ID" value="BAJ62826"/>
        <property type="gene ID" value="ANT_07920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07920"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="ADRANDW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="251" mass="27707" checksum="5CE3587F67AA3B47" modified="2011-04-05" version="1">MMDTLVPIIQTVQLVKIYGSGENRVTALDGIDLTIESGEFVAIMGPSGSGKSTLLNILACLDRPTEGQYILAGEDVSGYNRAQLAEIRSRQLGFVFQSYNLLPRLTALENVLLPLLYRREERLSHAERVEKALASLESVGLADRAHHYPNQLSGGQQQRVAIARALINDPLLILADEPTGNLDSHASEEIIELLTTLNQRGRTIVMVTHEPDMARHAQRVLMIRDGKLASDRKNGHHQESQSLSQVEGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Q7</accession>
    <name>E8N2Q7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nuoA</name>
        <name evidence="8" type="ordered locus">ANT_08290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559255.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08290"/>
    <dbReference type="EnsemblBacteria" id="BAJ62863">
        <property type="protein sequence ID" value="BAJ62863"/>
        <property type="gene ID" value="ANT_08290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08290"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_3_1_0"/>
    <dbReference type="OMA" id="RFPVKYY"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="118" mass="13512" checksum="5AD2E2D8BBDDCCF1" modified="2011-04-05" version="1">MLTDYFPLVVIIVFAVILAFLVVALGHLFGPKRPSEKKSMPYESGMVPYGPGQRRMTVRYYLIAVLFILFDIEVVFFLPWAVAFRDLGLPGFLLMVVFVVILEVAHLYAWKKGALEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V7</accession>
    <name>E8N2V7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561448.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30810"/>
    <dbReference type="EnsemblBacteria" id="BAJ65107">
        <property type="protein sequence ID" value="BAJ65107"/>
        <property type="gene ID" value="ANT_30810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30810"/>
    <dbReference type="HOGENOM" id="CLU_643476_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="426" mass="45602" checksum="4C26730ACCA043F9" modified="2011-04-05" version="1">MNLYLMIGGTGIPLQENGALRAARFVNSDLTRLELVLEGTPAAIGEAVQGLETALYTARASAHLPAHPACGLGVTLPDGQTWRSPLRGGKLESLPHPAARQVNRQMLVLEVEREPFWEQEGAPLTLLNRHGAGANATLYNHSDGAHDNFVDIPASQVQGSLPAPLEMTLSGALSGRSLVLLTAGTHDPATPFQHVLEGEQGVEGSGVSGTTLSASTASAGGYRRLTWSGVEEVTLKRFSLPASQSAAARGRFYRLTARLHAPLSETLLVWGEAGFEGSAGFEPLYAGEPAVIPASAQTLWLPPLRLPPWDVDTLSAGVTLTLKAQAETTGAHTLDLDCLFLTPTEAEARLLPLMSLSALALTYDPRTRGVKFSGAPLLTHTVEGQGIFLQPGQTQRLYVLLERNGAMTIEDTFTLQARPFFRRRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X8</accession>
    <name>E8N2X8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Elongation factor Ts</fullName>
            <shortName evidence="5">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">tsf</name>
        <name evidence="7" type="ordered locus">ANT_31020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31020"/>
    <dbReference type="EnsemblBacteria" id="BAJ65128">
        <property type="protein sequence ID" value="BAJ65128"/>
        <property type="gene ID" value="ANT_31020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31020"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_1_1_0"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="6">
        <location>
            <begin position="40"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="5">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="213" mass="24020" checksum="F7D6224AEF62731E" modified="2011-04-05" version="1">MNFEDFEKDGNKTMAITTEMIKQLRDATGAGILDCRKALEQSNGDYEKAVDYLREKGLAQAAKRSDRTASEGVIEVYSHGNGRVAVVVEVNCESDFVAREASFRAFAHELALQIAASSPRWVKEEDIPEAELKREADIAAARAREEGKPEAVIPRIVEGYLSKFKDETVLMRQKYIRDESKTIQDLYNELAVSLKENIVVRRFVRWELGEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y3</accession>
    <name>E8N2Y3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_31070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561474.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31070"/>
    <dbReference type="EnsemblBacteria" id="BAJ65133">
        <property type="protein sequence ID" value="BAJ65133"/>
        <property type="gene ID" value="ANT_31070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31070"/>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082936_0_0_0"/>
    <dbReference type="OMA" id="HVDFLIC"/>
    <dbReference type="OrthoDB" id="1999861at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024402">
        <property type="entry name" value="DUF2726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014538">
        <property type="entry name" value="UCP028063_topo_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10881">
        <property type="entry name" value="DUF2726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028063">
        <property type="entry name" value="UCP028063"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2726" evidence="3">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="zf-C4_Topoisom" evidence="2">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="232" mass="26207" checksum="DC6E96A35B416C75" modified="2011-04-05" version="1">MAVTKEKQGCLSLIFPFLRKNDLPEELPYRTRDDFLSPAELSFYKVLSSTLGARFTLQSKVRLADVFFVARPNENFAYFNRIAQRHVDFLICDPATMKPLLGIELDDSSHQRERRQKRDEFVDRVFEAANLPLVRFPVQRAYTTQELVEKIAPHLRNALGKPAAEAPATAPAVSDPPAPAKQDSAPLCPKCNIPMVLRTVTQGEHKGKQFYGCSNYPRCREVKPVPAQRPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z5</accession>
    <name>E8N2Z5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheC</name>
        <name evidence="2" type="ordered locus">ANT_31190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561486.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31190"/>
    <dbReference type="EnsemblBacteria" id="BAJ65145">
        <property type="protein sequence ID" value="BAJ65145"/>
        <property type="gene ID" value="ANT_31190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31190"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087860_0_2_0"/>
    <dbReference type="OMA" id="IVILMEV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="203" mass="21979" checksum="F8EB65465D9723AA" modified="2011-04-05" version="1">MHLSPEQMDTLTEMVNIGFGRAAASLSALVHQRIVLRAPEIALYPLEDLPHQLNFLSPEVTSVHQIFSGALNGDAILLLDYDSASILVNLLTGEPPIPRPLTSSDREALTEIGNILLNAFVGTLGNLLKVKIFFAVPRLNIEAVHEMLQTLNIGGNEIRYTLVVKTYFETSDGSVSGYVVMIMGLESLERLSAALNPAPESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N366</accession>
    <name>E8N366_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559272.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08460"/>
    <dbReference type="EnsemblBacteria" id="BAJ62880">
        <property type="protein sequence ID" value="BAJ62880"/>
        <property type="gene ID" value="ANT_08460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08460"/>
    <dbReference type="HOGENOM" id="CLU_854277_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228608" evidence="1">
        <location>
            <begin position="23"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="36087" checksum="F2313BA671B3E7AA" modified="2011-04-05" version="1">MKRFLQMLIACFSILGVTLACALDTPTPSPSVSTQQEQSIYRGLNAFSSYRRQATILFKGQDENGAPLEVQMDFLEEVNRDEQAQHRMSRIVLPNLPPGSFELYQMGDRQYLVSSEISASFPCIMLPQVTEQEDNVLKFDNLFEGLSLGEKLGTRTTFNGIEADHFRVGNLRLSLGTPQQWNAEVWVDAQHSTVLYFKGSAEGEFAIEGHAAKGTLSWEYYLLDLQNTHVSLPKECDNLTLKDLPLPLKILSAGWQGSQLTLKIAQSAQEAVNELRNALVQSGWELTADAGTGEVFTLSATKEGKVLQITIRSLEKGSQVEINLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N368</accession>
    <name>E8N368_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559274.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62882">
        <property type="protein sequence ID" value="BAJ62882"/>
        <property type="gene ID" value="ANT_08480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08480"/>
    <dbReference type="HOGENOM" id="CLU_1105352_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="251" mass="28029" checksum="EDA03AA8AC79718A" modified="2011-04-05" version="1">MELTPSWIVILTEWLGVIAVAWLLSATPRFRKQTVGFRYARRDGIVALTVGGVLVLIGWIFASSSPGKMLWELIRLPEPARSLNPLFILAMISLVITLAALFLRGQPLKGAGWNTTNLRLGIQTGLALALLTIFLRNRVMDVLNGLSREEIAYLLVVLGIALAEETIFRGYVQMRLCWWLGERQGVLATAALNTLWRLPLLLASGAYIVLWLNLVIMIGQAILSGWLMQKTGSVLTTILYRTTSLWMNFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G3</accession>
    <name>E8N3G3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenide, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">selD</name>
        <name evidence="8" type="ordered locus">ANT_09430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09430"/>
    <dbReference type="KEGG" id="atm:ANT_09430"/>
    <dbReference type="eggNOG" id="COG0709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032859_0_1_0"/>
    <dbReference type="OMA" id="DNEPKYG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0711">Selenium</keyword>
    <keyword evidence="8" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="61"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="179"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="8">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="357" mass="38773" checksum="4102D42844EF1B65" modified="2011-04-05" version="1">MSEAEPFANNGRKIRLTTLSSCAGUASKLNAETLAHVLRPLKDVFATQQYPDLLVGLDQPDDAAIWRLSDDRALVITTDFFTPVVDDAYDYGAIAAANSLSDIYAMGGEPFLALNVAALPPQLPHELLAEIIRGAAEKAREAGVVVAGGHTVQDKEPKFGLVVVGFVHPGKILTKSGARVGDRLVLTKPLGFGTVTTALKRGVAEPQDIEEAVTWMKQLNRQAAQLARQFDLKAGTDVTGFSLLGHALEMARESGVGMRFRYSQIPFLSCAYKYARQFIFPGGASDNRLYFGQWVQFDANLDEHEQMLLFDPQTSGGLLLAVPSDRIDAFLEEAPTQGISIWEVGEVVSGEGIEVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G8</accession>
    <name>E8N3G8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">coaE</name>
        <name evidence="2" type="ordered locus">ANT_09480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559373.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62982">
        <property type="protein sequence ID" value="BAJ62982"/>
        <property type="gene ID" value="ANT_09480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09480"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_724895_0_0_0"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="381" mass="42272" checksum="B84B5238B903F5BD" modified="2011-04-05" version="1">MSSWPGKYVIGLTGNIGTGKSVVRRMLEHLGAYGIDADALAHRAIAKGAPGYQPVIDHFGRWILTPDGEIDRAKLARVVFADGEALARLENIIHPLVRQGIEWLVQRSSQKVIVIEAIKLLEAGLNKTCDSVWVTYTPPEIQLARLMQYRKMSEAEARQRIAAQPPQEQKIGAATVVIRNDGSFEETWKQVMAAWKRLVPQTLEAAQEAHTQPRRAVPQGEITVSRGKPKDSEDIAGLINRLRKPAKPVTREDVMAAFGEKAFLILRVGNQPGGLLGWQVENLVARTVDILLDTSLPASDVLPPLIEEMERSSRNLQCEASLIFAPPELAQESLWKPLGYEKRTPQTLGVSAWQEAAVESLRPGTTLFFKQLRADRVLRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M4</accession>
    <name>E8N3M4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplC</name>
        <name evidence="9" type="ordered locus">ANT_10040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559429.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63038">
        <property type="protein sequence ID" value="BAJ63038"/>
        <property type="gene ID" value="ANT_10040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10040"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_0"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="209" mass="22525" checksum="90CE495BCC259A58" modified="2011-04-05" version="1">MLKGLIGKKIGMTQIFDENGVAIPVTVIEAGPCYVTQVRTPENDGYSAVQLGFEEVKPKRLTGGELGHLKRNNLPPLRFLREFRVKNPEVKEGDKVTVECFAVGERVDVVGTSKGKGFQGGVKRYHFRGGPKTHGQSDRHRAPGSRSSGTTPGRVYKGSRGPGHMGNDRVTAQGLKVVLVDTERNLIGVKGSVPGAKGGLVVIKEARKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P0</accession>
    <name>E8N3P0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rplR</name>
        <name evidence="8" type="ordered locus">ANT_10200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559445.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10200"/>
    <dbReference type="EnsemblBacteria" id="BAJ63054">
        <property type="protein sequence ID" value="BAJ63054"/>
        <property type="gene ID" value="ANT_10200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10200"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_0"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="121" mass="13492" checksum="95A1F29AAF85D40B" modified="2011-04-05" version="1">MAKRTRAEGRLHRHRRVRMKVQGTPERPRLSVYRSLAEIYAQVIDDQAGHTLAAASSIDHELREKTAGLNKTEQAKLVGKLVAERALAKGIKQVVFDRGGFRYIGRVKALADAAREAGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V3</accession>
    <name>E8N3V3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two-component response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_10830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559507.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10830"/>
    <dbReference type="EnsemblBacteria" id="BAJ63117">
        <property type="protein sequence ID" value="BAJ63117"/>
        <property type="gene ID" value="ANT_10830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10830"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3851">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="363" mass="41647" checksum="357E788FCF9E8F59" modified="2011-04-05" version="1">MTRILVVEDEEMVRANIVDLLEAEGYETQEASDGEQALQLIWQNPPDLILCDVRMPRVDGFTFLARISQEPRLRAIPFIFLTARVEREDQRLGMNLGADDYITKPFTRKDLLTAVQRRLEKHRHIGETAIHHHAHTVEQALKDLPDDLIAPIQYLLALSQSLMSGMELPGHISQMRELGRDVYKKTYQLLNSARQYVLLNRIFRIEKDLEQVQALRNLITFSAHEVMRDIAMSFAQQQDRAADLAIDLEPVSLAMGEEWLVNLLECALGWVFSKSSLGEKIVLEGKNLSANRYEVRLVYTPVHLLVEEYTAEWSAEKTPLSLRLMATIADFHEGSFTFNPGTPHSEMHFSLKSENRERGLFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W3</accession>
    <name>E8N3W3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559517.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10930"/>
    <dbReference type="EnsemblBacteria" id="BAJ63127">
        <property type="protein sequence ID" value="BAJ63127"/>
        <property type="gene ID" value="ANT_10930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10930"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_2_0"/>
    <dbReference type="OMA" id="LMSNADW"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="133"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="693" mass="78885" checksum="20396AAF4B64B459" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Z4</accession>
    <name>E8N3Z4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_11240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63158">
        <property type="protein sequence ID" value="BAJ63158"/>
        <property type="gene ID" value="ANT_11240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11240"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2912328_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="61" mass="6856" checksum="BF466649CE5AEA59" modified="2011-04-05" version="1">MPVILDLQTIPNWLHETSAARLKTLLVPFEADRMVAYPVSRQVNSPAVDSPELILPESQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Z9</accession>
    <name>E8N3Z9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_11290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559551.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63163">
        <property type="protein sequence ID" value="BAJ63163"/>
        <property type="gene ID" value="ANT_11290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11290"/>
    <dbReference type="HOGENOM" id="CLU_1438351_0_0_0"/>
    <dbReference type="OMA" id="IRERWRS"/>
    <dbReference type="OrthoDB" id="2167739at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="188" mass="21629" checksum="93690BD7C62E2E7B" modified="2011-04-05" version="1">MNDISQYHLKYLKLAIPDLESYVLSPTIFWPLPSASSSINEPGMDQMTLGGVILSLKVITAFSLPEAMTFSDIINDIRERWRSNWAKKAAREFAQRVHNWEHTIQELTRQSAGRLNVYRGQVRNRVILELLKDEIPPEKPAELGALVSLDSTLRNLFVPGEFLWDTPLQSVFPQPRFWFLYLTSIPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N417</accession>
    <name>E8N417_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559569.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63181">
        <property type="protein sequence ID" value="BAJ63181"/>
        <property type="gene ID" value="ANT_11470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11470"/>
    <dbReference type="eggNOG" id="COG4189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902760_0_0_0"/>
    <dbReference type="OMA" id="WKLEGSQ"/>
    <dbReference type="OrthoDB" id="891543at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="327" mass="36456" checksum="2757FF25D6073820" modified="2011-04-05" version="1">MTDSSMTNYEKIPNARLLELLAEDHELQKLEAVTKALGSETRLKILKFLSVHTSTVMEIAEALGLPPSTATLHINILENAGLIKTDLRPATRGLQRVCARVYDRIIIQLPAYLETAETPIEVSMPIGAYTQIQAIPTCGLVGELGIIGHLDDPSAFYEPQRIYAQLIWFRRGFLEYHFPYRLPPGSILNEIEISFEVCSEAPLHHPDWPSDITLWIGGIEIGTWTSPADFGGERGMLTPAWWDTQNSQYGLLKVWKVTSTGSYVDGVQVSSIKVKDLPIKPGEPISVRIGIKENATNVGGMNLFGSKFGNYPQDIVMRQYFKRVGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N461</accession>
    <name>E8N461_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559613.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63225">
        <property type="protein sequence ID" value="BAJ63225"/>
        <property type="gene ID" value="ANT_11910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11910"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_1_1_0"/>
    <dbReference type="OMA" id="DEYLFPW"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="27678" checksum="46AB663853634957" modified="2011-04-05" version="1">MRVLVLSDIHANLTALDAVLKDAGTVDEVWCLGDIVGYGPDPNECIQRIRNLANLTCVLGNHDAAVLGWIPLDAFHRDARHAIYWTRSTLSRENLEWLAEIPERQTRENFTLVHGSPRNPVWEYLLDPISAAQNFAYFETDYCLIGHTHIPLQFSFVSPEYPARWTQPMVRRQVHLHPRAILNPGSVGQPRDHDPRAAYAILDTEEALWHARRVLYDIEAVQERILSADLPRRHAARLSDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N483</accession>
    <name>E8N483_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1-phosphate synthase</fullName>
            <ecNumber evidence="3">5.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559635.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12130"/>
    <dbReference type="EnsemblBacteria" id="BAJ63247">
        <property type="protein sequence ID" value="BAJ63247"/>
        <property type="gene ID" value="ANT_12130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12130"/>
    <dbReference type="eggNOG" id="COG1260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_0"/>
    <dbReference type="OMA" id="GTKEWAD"/>
    <dbReference type="OrthoDB" id="669352at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="193"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="360" mass="39950" checksum="D27C609414191F78" modified="2011-04-05" version="1">MGNKKVRVAIIGVGNCASSLVQGVYYYRNAADTDRIPGLMHVNLGGYHISDIEFSAAFDVVDTKVGKDLSEAIFAYPNNTYQFTKVPHLNVPVSRGMTHDGLGKYLSQIVKKAPGPTADIIKILKDTGTDVVINYLPVGSEMATKWYVEQVLEAGCGFVNAIPVFIASSEYWSERFRQKNLPIIGDDIKSQVGATILHRVLTSLFVDRGVRLDRTYQINFGGNTDFLNMLERERLESKKISKTGAVTSMLPYDIGENNIHVGPSDYIPWLTDRKWCYIRMEGTTFGDVPLNLEAKLEVWDSPNSAGVVIDAVRCVKLAMDRGIGGPLYAPASYFMKTPPKQFKDEIAREMTEAFIRGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E3</accession>
    <name>E8N4E3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulphurase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559695.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63307">
        <property type="protein sequence ID" value="BAJ63307"/>
        <property type="gene ID" value="ANT_12730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12730"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_2_0"/>
    <dbReference type="OMA" id="PYRLIDI"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011340">
        <property type="entry name" value="Cys_dSase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01976">
        <property type="entry name" value="am_tr_V_VC1184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="19"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="302"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="419" mass="47067" checksum="A58EF32D7AA73B1E" modified="2011-04-05" version="1">MLNLAVIRSQFPALEKPVVFLDNPGGTQVARSVVERMTRYLTESNANHGGEFETSRISDAIVDEARQRMADFLNARRTEEIIFGPNMTSLTFQMSRALGKQLRPGDTIVVTRLDHDANISPWVKLAEDLRLTIRWVDFHPEDGTLNLEDFEQAMRERPRLVAFGYASNALGTVNPVAELVARAHRVGALTYVDAVQYAPHGPIDVQTLDVDFLVCSAYKFFGPHVGVLYGKYELLESLPAYKVRPAPEEPPGKFEMGTGNFEGIAGVLGALEYLEWMGKTFGGEVEESLPSQFTGRRRYFKSAMAAIRAYEFSLSRTLLDVLEEIPGIAIYGITDHRRLEERVPTVSFTLNGKNPKEVARMLDERQIQVWNGNFYALAVTQRLGLEESGGLVRVGPVHYNTIEELERLGRALWEIARMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G8</accession>
    <name>E8N4G8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ANT_12980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63332">
        <property type="protein sequence ID" value="BAJ63332"/>
        <property type="gene ID" value="ANT_12980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12980"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280151_0_0_0"/>
    <dbReference type="OMA" id="NWWFPEG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019962">
        <property type="entry name" value="CHP03663"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41710">
        <property type="entry name" value="PTHR41710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="12">
        <location>
            <begin position="80"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="9">
        <location>
            <begin position="863"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="9">
        <location>
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            <end position="959"/>
        </location>
    </feature>
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            <end position="1008"/>
        </location>
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        <location>
            <begin position="1012"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1155" mass="129168" checksum="F07DA0668AAA7F96" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I5</accession>
    <name>E8N4I5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Toast_rack_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559736.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13170"/>
    <dbReference type="EnsemblBacteria" id="BAJ63349">
        <property type="protein sequence ID" value="BAJ63349"/>
        <property type="gene ID" value="ANT_13170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13170"/>
    <dbReference type="eggNOG" id="COG4758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982261_0_0_0"/>
    <dbReference type="OMA" id="ANFREME"/>
    <dbReference type="OrthoDB" id="1623927at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031346">
        <property type="entry name" value="DUF2154_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17115">
        <property type="entry name" value="Toast_rack_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toast_rack_N" evidence="1">
        <location>
            <begin position="45"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="283" mass="31260" checksum="E032312A82A455E8" modified="2011-04-05" version="1">MKRYAFLIWLGLLMLLALACTIELPLPEVRLIAPQTYEIKEPYPDQEPAELLIRMGAGELTLSGGADNLVEGKVEYNVEGWEPEIQREGREVRVEQGVKSANFTRGVQNLVNRWELTLGKRSMDFALEAGAYDGNLDFSDVPLTRLRISDGASKVRVVFNVPNPEVMRSFTYETGASNITLKKLANANFEEMTFKGGAGNFTLDFSGKLQREARVWIDSGLGNMTVIVPADANCRIVLSGGLTNVSTEGTWTIQGQEYRTKGEGPQLRIDINVGVGNLKLVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4P6</accession>
    <name>E8N4P6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rex</name>
        <name evidence="8" type="ordered locus">ANT_13820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
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            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
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        <property type="protein sequence ID" value="BAJ63410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13820"/>
    <dbReference type="EnsemblBacteria" id="BAJ63410">
        <property type="protein sequence ID" value="BAJ63410"/>
        <property type="gene ID" value="ANT_13820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13820"/>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061534_1_0_0"/>
    <dbReference type="OMA" id="HEQRKAG"/>
    <dbReference type="OrthoDB" id="1872374at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="7">
        <location>
            <begin position="79"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="206" mass="22943" checksum="9FE7DE7BFAD0C1F2" modified="2011-04-05" version="1">MNDKPIPDIVIGRLPRYLQALEHMLEQGYAVTSSKELGEQIGISAAQIRKDLSQYGEFGKQGKGYSVPFLVTQLKQILKVDRIWDMALIGAGNLGKAIANYQGFTEHGFRVALIFDSDPQKVGQVIHQIPVLHTSTMIETIQSHHIKIAMLTVPAQVAQSVTNQLIQAGIKAILNYAPITLSVPEDVHVQYVDPIIHLQRMTYYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T3</accession>
    <name>E8N4T3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_14190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559829.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63447">
        <property type="protein sequence ID" value="BAJ63447"/>
        <property type="gene ID" value="ANT_14190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14190"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_0"/>
    <dbReference type="OMA" id="MWRWQRE"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="193"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="254" mass="28458" checksum="21654C065484F4C9" modified="2011-04-05" version="1">MTNQPVRLFYRERGQGKPMILIHGFPLDHSIWDAVAEDLSKKARVITPDLRGYGKSPKPEGEYTMRMMADDLIALLDQLGIDKAIMVGHSMGGYITLALAKAYPQRLSGIGFVATQAAADLPERRQARLILVDEIKRKGAQAVVHANLKKYSRNAEVLKYTQELMLKAQPHVLMACLRGMADREDMTDFLKEIAVPSVVIAGEQDDLIPLERTREMVERLQRGWLVTVPNAGHMPMMESPQQVTSALIELLQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z1</accession>
    <name>E8N4Z1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_14770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559887.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63505">
        <property type="protein sequence ID" value="BAJ63505"/>
        <property type="gene ID" value="ANT_14770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14770"/>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_0_1_0"/>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="OrthoDB" id="944891at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="296" mass="33345" checksum="FECB138ACB44069F" modified="2011-04-05" version="1">MTEERPFLSGGEVAREGDLVQLVGTNHRHFIFRLRTGAEFQTHRGILYHDELIGKPYGSQVYSHIGTPFFMLQPSLADLLMNIRRNTQILYPKDIGYILVWMGIGPGARVIEAGTGSGALTMAFAYMVGETGKVYTYETRVEMFNLAQKNLAAVGLDSRVVFHLQHISEGFEETRADALFLDLPDPWNYLPQVKQALKPGGYFGSLLPTTNQVQTLLAELHRQGFAFINVSEILLRHYRPDPARFRPTDRMVAHTGFLIFARTVLHLPEDPKLRRELRFPLGDSVSEGVEDDDLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N543</accession>
    <name>E8N543_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559939.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63557">
        <property type="protein sequence ID" value="BAJ63557"/>
        <property type="gene ID" value="ANT_15290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15290"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078484_0_2_0"/>
    <dbReference type="OMA" id="GAREYAD"/>
    <dbReference type="OrthoDB" id="1602369at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="153" mass="17676" checksum="56AA4611891BD1FD" modified="2011-04-05" version="1">MDILHLVDRLEELFNESRPFPLTHSVLVNEDRMLDIIDQMRVSIPEEIKKAQQILAQRDRILAQAQEEANRTIALAREKSEQLVSRDSIVAEAQARAEQIIQQAHVDAANIRKEADDYVLESLTRLEAELERILTQVRNGVRTLQSERRSPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N584</accession>
    <name>E8N584_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559979.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63598">
        <property type="protein sequence ID" value="BAJ63598"/>
        <property type="gene ID" value="ANT_15700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15700"/>
    <dbReference type="HOGENOM" id="CLU_2079848_0_0_0"/>
    <dbReference type="OrthoDB" id="2139843at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="12631" checksum="2299CF8966977CE2" modified="2011-04-05" version="1">MKTIGYILASILIFFGVLFIWGAFGAQGQPVWIVIGIITVGIGLLLVYFASKKPKVEAAPNITLKVDLPGNVNLDTLKCRSCGGVLNAENIKMVNGAPVVTCPYCSTVYQLTEEPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5F3</accession>
    <name>E8N5F3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63667">
        <property type="protein sequence ID" value="BAJ63667"/>
        <property type="gene ID" value="ANT_16410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16410"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587481_0_0_0"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228648" evidence="1">
        <location>
            <begin position="26"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="465" mass="50969" checksum="ABE3433A73F041C7" modified="2011-04-05" version="1">MIMKKCFLFFLVIVLLFSNPFGVHAQDQTPSAPVYIVQSGDTMYTIALRFNVPLSELITANPSINPDLLQAGMEVVIPGLEGVSGVLSTEAIPLGMGLDDLARFRNVSRDLLIRLNKITSPAEVYAGSNLVVPEKEAQIYHEGLGRLSPQKSLLQVAVEKNLNPWSIALSHQQLSTQTVLSGEMLYSLSSEKAPTPNPLMPIVQSIVLSPLPLVQGRTVVITVQTTQPVEISGSLNDRALEFFENRKNEFVAIQGIHAMANPGLIPFSLQVKTSDGNTLSFQQEIILMSGYYPQDPPLSVDPATIAPENTRPEDDLIREIVSKVTPEKLWDGMFALPVDEPYCIRSGFGNRRSYNGSPYTYFHTGLDYGVCANLNIRAPAAGVVVYTGDLTVRGKSTIIDHGWGVFSGFWHQQEILVNVGDKVEPGQLIGLIGGTGRVTGPHLHWEVWANGVQVNPQQWLEQSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R9</accession>
    <name>E8N5R9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17570"/>
    <dbReference type="EnsemblBacteria" id="BAJ63783">
        <property type="protein sequence ID" value="BAJ63783"/>
        <property type="gene ID" value="ANT_17570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17570"/>
    <dbReference type="eggNOG" id="COG2317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_0"/>
    <dbReference type="OMA" id="THHPFMT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="508" mass="58703" checksum="8E6E1AAC21A4C2B3" modified="2011-04-05" version="1">MLKGWTKMEEKMRDLKQRLSEIHDLEMANAVLGWDQLTYMPPGGAEARGRQMATLARLAQEKMTDPGLGKLIEELLPYADSLPEDHDDAALIRVAKRDFDRLTKIPPQLIARVYEHQSRCYMAWTEARPNNDFEKVRPLLEQTLEYSREVANCFPGYEHIADPLIDWADYGMKAKNLRVLFDQLRQELVPLVQAITSYPPSDDSCLRQHFPEKDQIAFGEQVIRALGYDFQRGRQDKSPHPFTTRFGYGDVRITTRVKENDFGEAFFSTVHEAGHAMYEQGCNPAFDGTPLFGGTSAGVHESQSRLWENVVARSREFWEYYYPLLQKTFPGQLGNVTLDTFYRAINKVQPSLVRTDADEVTYNLHVMIRFDLELQMLEGSLEVKHLPEAWNERYRSDLGVVPPDDRDGCLQDVHWYGGFIGGQFQGYTLGNILSALFYHHAVLEIPSIPEEIRQGKFENLHGWLKEHIYQHGRKYTAPDLIRRVTGRDLDIQPYIAYLKRKYGELYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T4</accession>
    <name>E8N5T4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">hisS</name>
        <name evidence="10" type="ordered locus">ANT_17720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560176.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="SMR" id="E8N5T4"/>
    <dbReference type="STRING" id="926569.ANT_17720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63798">
        <property type="protein sequence ID" value="BAJ63798"/>
        <property type="gene ID" value="ANT_17720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17720"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_1_0"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="426" mass="48723" checksum="693F5492B36C1C34" modified="2011-04-05" version="1">MKAIVPSVKGTRDFYPEIMAVRNWLYARIREVSEKFGYQEYEGPFLERVDLYAAKSGEELVNEQSFVFQDRGGDYIALRPELTPTLARMVAQRQNELVYPLRWWSFGPFWRYERPQKGRTREFFQWNIDIIGSQAIEADAELLAVAVEFFKSVGLTSQQVKLLVNNRRLMDVQLENLGIREGQKRDVFRLIDRKEKLPLPEWRQYAFDFGLTQEQLSGLESLLVNESLWETSDELKRVFELLEGMGIREYVEFAPQIIRGLDYYTGTVFEAKDLDGGRSILGGGHYDNLVANVGGEPLPGVGFAMGDVMITLVLEKYGKLPALETAPAQVLVTVFDLERLPQSFALAARLREQGLKVVWYPEAAKLQKQLKFADRAGIRFAVIYGPDEISAGQVALKDLHQRNQELVSVENVGERVRQILAQSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T5</accession>
    <name>E8N5T5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DRTGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63799">
        <property type="protein sequence ID" value="BAJ63799"/>
        <property type="gene ID" value="ANT_17730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17730"/>
    <dbReference type="eggNOG" id="COG4109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140224_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="151" mass="16475" checksum="E6CCA1320E366BC7" modified="2011-04-05" version="1">MEIHYSEFSIGYSGVKSIKISVWMNHMNLNELAELINGKYLNQTTPTLKEIKGAFAADLMSDVLATIQPHAVLITGLCNPQVIRTAVMADITAIVFVRGKQPPQETIDLADEESIPIISTPMGMYEVCGKLYVAGLSSLEQVVNPDECDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U5</accession>
    <name>E8N5U5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560187.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17830"/>
    <dbReference type="EnsemblBacteria" id="BAJ63809">
        <property type="protein sequence ID" value="BAJ63809"/>
        <property type="gene ID" value="ANT_17830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17830"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_16_0_0"/>
    <dbReference type="OMA" id="CLRGKCE"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="19513" checksum="AE3073D1D35A30B4" modified="2011-04-05" version="1">MNMRQTHLTEIYQGIPLFHGFSPEILTRLAQISRVREVPPQEFLFKEGDTDRTLYILLDGEVKLSCYAPGYGEVVIAKAEALDILGWSSMTSMIRQRLESAQTTRRSTLLCIDTEALQKICDENPAIGYQIAQRIANLAATTLMQSRINLLQIIREQATQRYKEDTLEFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5X3</accession>
    <name>E8N5X3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pyk</name>
        <name evidence="14" type="ordered locus">ANT_18110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560215.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63837">
        <property type="protein sequence ID" value="BAJ63837"/>
        <property type="gene ID" value="ANT_18110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18110"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_0"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="3"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="366"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ63837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="492" mass="54010" checksum="658B3F4764DAD7EA" modified="2011-04-05" version="1">MKRRVKIIATLGPACENAETIRAMAEAGMDVARLNFSHGTHEQHAQRIQTVRQISKELGKEITILQDLQGPKLRVGVLPENGVDLYPGELIVLTSKKELPEVPHSAKILPMDVPNLEASVHEGSRVLMDDGNLELRVKEVTPDYIISEVINGGKLRSQKGVNLPEANLGIEGFTEKDQADLMFGLEHGVDAVAMSFVRTAEDIRTVKRAIESWCPEKCSVPLVIAKIELPEAIQNLHEIVHEADGVMVARGDLGVEMSLAEVPTLQKEIIYLANRHAKIVITATQMLETMIQNPRPTRAEASDVANAVFDGTDAVMLSAETAAGKYPVEVIRTMASIVTDAEMNYTMWGHYKDLPREAVQSDALSITWAARELAHDRDVRAIVVFTETGRTALYTSKSRPAVPILAFTPVQETLQKLGLFWGVSAHLVPFANSVESMIQIVEEMLLGKLGFSKGEQIVLISGLPVGAMRQPNFCLLHTLGETYTYSGNDKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N617</accession>
    <name>E8N617_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560258.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18550"/>
    <dbReference type="EnsemblBacteria" id="BAJ63881">
        <property type="protein sequence ID" value="BAJ63881"/>
        <property type="gene ID" value="ANT_18550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18550"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047251_0_0_0"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="33468" checksum="8FACFA2CA676C866" modified="2011-04-05" version="1">MDIALALGGGGVKGIAHIGVLQALEQAGFRIRAIAGTSIGGLVGGVYAAGNSPLKILQTVQQLDMNLVYKRRAEDGPALLGHAGMVEVLNTLLHNRRFEDLEIPFACTAVDIHSHREVYLTKGDVIQAILATTAFPGVLPPQEHKEMLLVDGGVLDPVPVLLARKLAPNLPVLAVVLQPPPEDWDKIPEGDLITTTPLPIPSPLIQGFIRMRIGQAARIFIEAMDINSRMLTELRLHVDKPDFVLRPNVFRFGIFEPADPLVLFNAGKEIVEQKLGQIRDSFSWKGKLLRFLKADSSSTVLKILKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N619</accession>
    <name>E8N619_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase/carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18570"/>
    <dbReference type="EnsemblBacteria" id="BAJ63883">
        <property type="protein sequence ID" value="BAJ63883"/>
        <property type="gene ID" value="ANT_18570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18570"/>
    <dbReference type="eggNOG" id="COG0400">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_5_3_0"/>
    <dbReference type="OMA" id="HYCESST"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="203" mass="22690" checksum="027C3C0D10FE1D72" modified="2011-04-05" version="1">MIQMPDEEPAQQIILFLHGWTGDENSMQIFSQVAPPSSVKIFLRGYLPAPTGFGWAPPRQGVWIDMDKFKPSSGLILQTLEHIRKKFPEMVQKPIVPIGFSQGGAMALALLYYYPEEIFQAAVLSGFLPKISILDVSFTDKSIFLSHGTKDEIIPVEMARESVKILTQAGARVHYCESSTGHKTSAECLKRLRAFLEENLHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N629</accession>
    <name>E8N629_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560270.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63893">
        <property type="protein sequence ID" value="BAJ63893"/>
        <property type="gene ID" value="ANT_18670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18670"/>
    <dbReference type="eggNOG" id="COG3225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018716_0_0_0"/>
    <dbReference type="OMA" id="YGQHPIT"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="98"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="515" mass="56692" checksum="4849BAC5794F2977" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N649</accession>
    <name>E8N649_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560290.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63913">
        <property type="protein sequence ID" value="BAJ63913"/>
        <property type="gene ID" value="ANT_18870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18870"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_3_2_0"/>
    <dbReference type="OMA" id="HEATSRW"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04623">
        <property type="entry name" value="CBS_pair_bac_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044725">
        <property type="entry name" value="CBSX3_CBS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="146" mass="16606" checksum="8FDD897B54777515" modified="2011-04-05" version="1">MATVKELLEEKGYDVWTVSPEMTLREALKLMAEKHIGAVPVLENGQVVGIFSERDFARHAVEFSECLDLEVPVRQLMTHPVYYVNLEQTVDECMAVMTAKKLRHLPVIQEGKLIGLISIGDVVKHILADKQNTIELLEHFLWVNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N662</accession>
    <name>E8N662_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">secE</name>
        <name evidence="9" type="ordered locus">ANT_19000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63926">
        <property type="protein sequence ID" value="BAJ63926"/>
        <property type="gene ID" value="ANT_19000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19000"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_7_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="108" mass="12170" checksum="9CB06E366FD9090B" modified="2011-04-05" version="1">MAEKTLKTKQQEKVKEVASPKTASVVRKEQKPKVETPRAAEKKQSARPGRLATWWRETIGELRKVTWPTLPEARRLTVIVLIVVGVTSLALGLLDWVFSRLIALLISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D2</accession>
    <name>E8N6D2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560369.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19700"/>
    <dbReference type="TCDB" id="9.B.27.1.5">
        <property type="family name" value="the death effector domain a (deda) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63996">
        <property type="protein sequence ID" value="BAJ63996"/>
        <property type="gene ID" value="ANT_19700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19700"/>
    <dbReference type="eggNOG" id="COG1238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114458_0_0_0"/>
    <dbReference type="OMA" id="GLPYWIF"/>
    <dbReference type="OrthoDB" id="1149870at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19830" checksum="F1CF28BEB99D494D" modified="2011-04-05" version="1">MKPETRLRIVRLLLLLLVIALSVSIYLYRDQVKQLAALGYPGLFLVSLLTNATLILPVPGVLFTSLMGAVFHPFWVALVAGTGSALGELSGYLAGISGRGVVERSELHDRLVYWMRRYGVWTVLVLAFVPNPIFDVAGIIAGMLKMPVWRFLLFCWIGKVLKMLMFAYGGAGLLNFLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH0</accession>
    <name>E8MXH0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560421.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20250"/>
    <dbReference type="EnsemblBacteria" id="BAJ64051">
        <property type="protein sequence ID" value="BAJ64051"/>
        <property type="gene ID" value="ANT_20250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20250"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_0"/>
    <dbReference type="OMA" id="IRCFSYI"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="175"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="42923" checksum="FA37C15FFC863F08" modified="2011-04-05" version="1">MTKVLVTGGAGFIGSHLVDRLLQEGFEVRVLDLLDSRVHPAGKPAWVSKEAEFIQGDVRDAQTMLKALQGVSIVFHEAAYQDYMPDFSRFLHVNSVSTALIHELILEHKLGVEKVIVASSQAVYGEGQYRCKNSNCQNYHQVIQPPAREEKQLQKGHWEVICPLCQTDMEPLRLKEEYANPYNAYAISKYAEELSAVRLGKLHHIPSVALRYSIVQGPRQSLFNQYSGICRIFSVRLMNGLPPIIYEDGLQTRDFTHVADVVEANITVLKDARADYQVFNVGSGHAITVLEYARVLTQQFGLSIEPLLQGEYRLGDNRHSVSDISRLQALGWQPTRTLHHIFDDYLQWIANQGNVLDYFKVAETSMKKAGVVRKVSSFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH5</accession>
    <name>E8MXH5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560426.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64056">
        <property type="protein sequence ID" value="BAJ64056"/>
        <property type="gene ID" value="ANT_20300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20300"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028014_0_1_0"/>
    <dbReference type="OMA" id="WWPEPAD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="397" mass="45140" checksum="C4D48114A9804E83" modified="2011-04-05" version="1">MHILFLSRWYPFPPNNGSKLRIYNLLRFLGQSHTITLVSFYDPDEGIVQEPVPSFCKEVYTLPWKEFRPTHWKALLGFFHPYPRWVVDTYSREMEHLVNGLLEKHSFDVVIASQTIMAPYARKIQGTHKILEEAEVGVFIHRARKSSGTLGKFRHSLTWLKYQQYLQGLFRDFASITVVSEEEKSYILPLTPQPEKVEIIPNGVKVQDYETVMRNPVPNTLIFTGSFRYSANYEAMMWFVSQVFPLIQAEIPEVRLIITGDPAGKRLPFNPQVTQTGGVPDVREWIASSWVAVAPLQIGGGTRLKILEAMALRTPVVSTSKGAEGLDVHSPKHLIIADSPAEFARAVIAICQDPALREKIATSAFDLVKEKYDWDSILPRYQEILTGITSPKVLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL3</accession>
    <name>E8MXL3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20680"/>
    <dbReference type="EnsemblBacteria" id="BAJ64094">
        <property type="protein sequence ID" value="BAJ64094"/>
        <property type="gene ID" value="ANT_20680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20680"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_1_1_0"/>
    <dbReference type="OMA" id="RYNQSAL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DZR_2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="244" mass="27115" checksum="F81EF6F1D7F8AE3D" modified="2011-04-05" version="1">MRPASFLYHLGWTAVDWLFPPYCLDCGTLGERWCETCQQKISLLAPPLCERCGRPVELAGLCVECQHAPISMDAIRSCYAYEGIIREAIHRLKFEKDLGLAEILANALIKVLSMQDWNIDVITSVPVSPARMKERGYNQAEMLAFPLALNTGVPYKRSLLKRVKDAPSQVGLSKEERRENIREAFEGLPQASQYSSVLVVDDVVTTGSTLQSCALALREQGVKQVYGLTLARAISRDPLARATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ0</accession>
    <name>E8MXQ0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methylthioadenosine/S-adenosylhomocysteine deaminase</fullName>
            <shortName evidence="1">MTA/SAH deaminase</shortName>
            <ecNumber evidence="1">3.5.4.28</ecNumber>
            <ecNumber evidence="1">3.5.4.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtaD</name>
        <name evidence="3" type="ordered locus">ANT_21050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57985"/>
            <dbReference type="EC" id="3.5.4.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine</text>
            <dbReference type="Rhea" id="RHEA:25025"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:48595"/>
            <dbReference type="EC" id="3.5.4.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.28" evidence="1"/>
    <dbReference type="EC" id="3.5.4.31" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560501.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64131">
        <property type="protein sequence ID" value="BAJ64131"/>
        <property type="gene ID" value="ANT_21050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21050"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_0_0"/>
    <dbReference type="OMA" id="FCPVERL"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090614">
        <property type="term" value="F:5'-methylthioadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050270">
        <property type="term" value="F:S-adenosylhomocysteine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01281">
        <property type="entry name" value="MTA_SAH_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023512">
        <property type="entry name" value="Deaminase_MtaD/DadD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="466"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="654" mass="73484" checksum="89C11E1C2176D6A7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR6</accession>
    <name>E8MXR6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64147">
        <property type="protein sequence ID" value="BAJ64147"/>
        <property type="gene ID" value="ANT_21210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21210"/>
    <dbReference type="eggNOG" id="ENOG5033N5H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734965_0_0_0"/>
    <dbReference type="OMA" id="GTWWREY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031009">
        <property type="entry name" value="Tcm_partner"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04474">
        <property type="entry name" value="tcm_partner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="376" mass="42915" checksum="C0E6B0EE45364FD3" modified="2011-04-05" version="1">MKTENSFFEEAKEWSCRKMAIVEKYLDGFTKILGNRASSSLVYIDGFAGRGIYGNDIKGSPVRAAELASGKYSNILQCVFVEKDDDNFNDLQQYTTQYYSCVEIYKGELSEYADKILSDAGDRAVLVFLDAFGVKGMGWKTVQKFISRKFITDCWLRLDHRTILRLLGYIDSDSKDARGKLDLLIETFGISDLNLLRQLTDAPSSLERIQKVVKLYQSRLKSCMGQNGFVGSYPIISLDGQKKYHLMFACKNRKAAVLANDIVNTVEDDLPVKQAEYQEHIRFQKTNQPSLLELTPSLEEIFHYKVNGLKQKILELLQSQSDILTIHYELLNQNPDLFGTFRRKHLTKALSELQEEGCIELDGAPSKEITKVYRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS1</accession>
    <name>E8MXS1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560522.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64152">
        <property type="protein sequence ID" value="BAJ64152"/>
        <property type="gene ID" value="ANT_21260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21260"/>
    <dbReference type="HOGENOM" id="CLU_1987995_0_0_0"/>
    <dbReference type="OrthoDB" id="893995at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="125" mass="14707" checksum="5183B0BA54F67679" modified="2011-04-05" version="1">MEKEVFKITRSVYRVADSGNEEIVFDFESQPISCTCGKADCEHIQTVRKYIFWSDEVANLTVTEEDVFRALEGRNQPKDWRRLIEYLSDHLADALNEHVYDEIRYLADAYEDQDVEEAEKEDVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW0</accession>
    <name>E8MXW0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560561.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64191">
        <property type="protein sequence ID" value="BAJ64191"/>
        <property type="gene ID" value="ANT_21650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21650"/>
    <dbReference type="HOGENOM" id="CLU_1727560_0_0_0"/>
    <dbReference type="OrthoDB" id="2168580at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="177" mass="20485" checksum="B3A73BEDCC34FA53" modified="2011-04-05" version="1">MSFAFRRHDYNLNEFDRCEKHGCPLMQVTAQAQPVCLMEWLALKAGERTVRDILPKDEGEYDLPALILDNGFMLPVVRAYPLAQKKRRVPPYLLPFLGGGNTAAVTDRFVGWWVSDLYHTRGETPLREAVMAMIRPPWKRGTTREDADNDRDAVLLHLALDILLYLLEDEEIRRYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX3</accession>
    <name>E8MXX3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560574.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21780"/>
    <dbReference type="EnsemblBacteria" id="BAJ64204">
        <property type="protein sequence ID" value="BAJ64204"/>
        <property type="gene ID" value="ANT_21780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21780"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1168754_0_0_0"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="237" mass="26614" checksum="BF74FF85A6A0608B" modified="2011-04-05" version="1">MTKIVTIYNQKGGVGKTTLAVNLAHGLARSGKAVTLMDLAEPPYCHQWFRLPADGSAQRWLKGEEVPRYGTRVGGLYVLTGYQPGVEELMSGKMEVLTPEAVRRERFDALGGDVVVVDGYRYEWKVEEALLGLSDVVLIPHDGGTPLDSTNWTLGECMELRRGGWQGRFYLVGQVERVGDVERLTAIGERADGVVLLTRNERMRQRRTAFETPRVARVMVEYHNLCMWLEKEGCQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY62</accession>
    <name>E8MY62_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560661.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64293">
        <property type="protein sequence ID" value="BAJ64293"/>
        <property type="gene ID" value="ANT_22670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22670"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_0"/>
    <dbReference type="OMA" id="ATDKAPQ"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="142" mass="15217" checksum="72ABF38F5273A95F" modified="2011-04-05" version="1">MCCSDEKRIYTSEKAPKALAPYSPAVKGGGLIFISGQLGLDPATNQLVEGGFEAECRQALNNLKNLVEAAGSTLDQVVKVTVFLKDINDFARLNSIYAEYFTVNPPARSAFQVAALPKNAAIEIEAIALAPECCCCHQDCCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY87</accession>
    <name>E8MY87_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22920"/>
    <dbReference type="EnsemblBacteria" id="BAJ64318">
        <property type="protein sequence ID" value="BAJ64318"/>
        <property type="gene ID" value="ANT_22920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22920"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_6_0_0"/>
    <dbReference type="OMA" id="IKRLARC"/>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="94" mass="10822" checksum="2AE988E57A271D5E" modified="2011-04-05" version="1">MGSMNEDYPNEPRLRDLPLTLWNIPRWVLLLLIRGYQKFISPGLPPNTCRFYPSCSHYGYQAVYKYGAIKGGLMAVWRVLRCNPFNPGGYDPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA9</accession>
    <name>E8MYA9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_00200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558452.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00200"/>
    <dbReference type="EnsemblBacteria" id="BAJ62054">
        <property type="protein sequence ID" value="BAJ62054"/>
        <property type="gene ID" value="ANT_00200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00200"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012344_3_0_0"/>
    <dbReference type="OMA" id="ANLGWSC"/>
    <dbReference type="OrthoDB" id="567019at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225150" description="GSDH domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="119"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="462" mass="49293" checksum="21DACDC6E235352C" modified="2011-04-05" version="1">MVIKEVTLRFVRRLFPLILLLGVLLAACSPQATPSPQPPTTTAPAPSAPETPTLYAPPAASNAGGTVPTLEGYQPPAETTPVPTSEAAYPAPGGNTVSSVTAFPDPAQFTWVQAAAGFQRPLDLADLSADGSRLLVLEQRGVIALVENGARRETPFLDIVERVGSSGNEQGLLGIALHPRFNENGFFYVNYTDRKGDTVIARFTANAERTAADPASEYVLLRVDQPAANHNGGGLTFGRDGYLYIGLGDGGQGGDPWGNAQSLKTHLGKLLRISVDGGEPYAIPANNPFADGQKGLAEIWAYGLRNPWRFSFDRLTGDLYIGDVGQNLYEEIDFLPAGSPGGANFGWDYREGLHPYEGTPPADAVFVEPVAEYAHPVGCSVTGGFVYRGAALPEFQGVYLYADYCTGKVWGLLRQADGTWKSQELFQLGGVSVSSFGQDALGEVYITDHQNGALLKLVRQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB6</accession>
    <name>E8MYB6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-hydantoinase</fullName>
            <ecNumber evidence="4">3.5.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_00270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558459.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00270"/>
    <dbReference type="MEROPS" id="M38.973"/>
    <dbReference type="EnsemblBacteria" id="BAJ62061">
        <property type="protein sequence ID" value="BAJ62061"/>
        <property type="gene ID" value="ANT_00270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00270"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_2_0_0"/>
    <dbReference type="OMA" id="RNFVCSP"/>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="49"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="471" mass="51529" checksum="06B8645893FBE45E" modified="2011-04-05" version="1">MRTLIKNGTLITAAETFRADILIEGEKIAAIGADLTAPDARVLDAEGKLVLPGGVDVHTHFDLPMFGTVSSDDHYTGHKAAAFGGTTTVIDFVSQDYPNLRQCVDAWHERVGGKAAVDYSFHMNITHLYPDTLAELPALLDEGISSVKVFTAYNNRLRLPDDDILRVMRVAGKHGILTMMHAENGDVIELLVAEALAQGRTEPVWHARTRPAWSAVEAVLRGAALAGMADAPLYVVHMNAAGEVDMLAYARAQGLPVMGETCPQYLFFSEEDLQRPDGAKWICSPPVRTPADQERLWQGLADGTLQALATDHCPFFYDGTQPIEYEGKPVAIPGKELGRGDFTRIPNGLPGVGDRLPVLWTYGVGAGRLTPNQFVALTATQPARIFGLYPQKGALLPGADADIVLWNPAQRLTYGVRYAHHRTDYNLYEGWELQGFPETVLLRGQVIVHQGEWRGRPGMGRFLKRSSGEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE4</accession>
    <name>E8MYE4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558487.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00550"/>
    <dbReference type="EnsemblBacteria" id="BAJ62089">
        <property type="protein sequence ID" value="BAJ62089"/>
        <property type="gene ID" value="ANT_00550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00550"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_2_0"/>
    <dbReference type="OMA" id="QTWREAY"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="177" mass="20147" checksum="43B0CB9F4BE2D90D" modified="2011-04-05" version="1">MTSIWIRPAVPEDAPALAQVHVETWRAAYRGIVDDEFLNSLDVAHREERWRQYLTSGESATFVATTDRGQVVGFVNAGAEREGLKPNMGEVYAIYLLPAYHRQGIGMRLMRRAARWLKSQGMRACLVWVLAENLPARRFYEALGGVLSREQNITIGRQILREVAYVWEAIEDLLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYH3</accession>
    <name>E8MYH3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cobalt ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_00840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00840"/>
    <dbReference type="EnsemblBacteria" id="BAJ62118">
        <property type="protein sequence ID" value="BAJ62118"/>
        <property type="gene ID" value="ANT_00840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00840"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_0"/>
    <dbReference type="OMA" id="VTHRVHA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="32"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="330"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="600" mass="65668" checksum="F98B79644E228E52" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI5</accession>
    <name>E8MYI5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trkA</name>
        <name evidence="7" type="ordered locus">ANT_22950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560688.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22950"/>
    <dbReference type="EnsemblBacteria" id="BAJ64321">
        <property type="protein sequence ID" value="BAJ64321"/>
        <property type="gene ID" value="ANT_22950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22950"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_0_0"/>
    <dbReference type="OMA" id="HGCRTVM"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="139"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="238" mass="25981" checksum="3E2B02BC45F0428B" modified="2011-04-05" version="1">MYVIITSGGRTGATLASMLISMDHEVKVIEWRKEVLSRIHHELPTEAIVEGDPLDLNILELAGIKKADVIAATTVSDEANLTLCYIARELYGINRTIARVNDPRNAWLFDDKYHVDVAVNQAELLASLIQEEMSLGDMITLLKLRRGRYSLVEEKIPAGARAIGTAIKDLDLPDHCVIAAIIRKGEVMIPRGVTTLEEGDEVLAVTDRDGAASLAGLFSAKQSEQNGKARNGEKSLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ0</accession>
    <name>E8MYJ0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23000"/>
    <dbReference type="EnsemblBacteria" id="BAJ64326">
        <property type="protein sequence ID" value="BAJ64326"/>
        <property type="gene ID" value="ANT_23000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23000"/>
    <dbReference type="HOGENOM" id="CLU_1999142_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="124" mass="14477" checksum="C08C51F943ECF41B" modified="2011-04-05" version="1">MFFEEKMPRYNYLNPPEDARAPQEVRIVDLKVEPAPDHRRVRVMVEITPFRERPDLTATLYQQDEEVTSAHIVENIDTHLAFTLHIRNPSDDPNYVLAVSVHYQEYGEVDQRSISFSLPPAVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM0</accession>
    <name>E8MYM0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mraZ</name>
        <name evidence="10" type="ordered locus">ANT_23300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560722.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64356">
        <property type="protein sequence ID" value="BAJ64356"/>
        <property type="gene ID" value="ANT_23300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23300"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_0_5_0"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="OrthoDB" id="1684767at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="145" mass="16973" checksum="386E99E5AC117894" modified="2011-04-05" version="1">MFLGRFEHNLDDKSRIIIPAKYRELIKSGAYVTQGFDRNLMVLTTEVFERVVTYLNELGMTNPDARTLKRLIFSSASPVTFDKLGRFLIPAYLREFARIENHVILVGVGDYFEIWSKEEWLKQESSLQNAEVNEHRFAAFEIHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN0</accession>
    <name>E8MYN0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">murC</name>
        <name evidence="15" type="ordered locus">ANT_23400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560732.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23400"/>
    <dbReference type="EnsemblBacteria" id="BAJ64366">
        <property type="protein sequence ID" value="BAJ64366"/>
        <property type="gene ID" value="ANT_23400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23400"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_0"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="106"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="314"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="108"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ64366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="461" mass="50454" checksum="48C8C07280B608EC" modified="2011-04-05" version="1">MERIHLIGIGGSGLSAIARLLVEQGVQVSGSDRAETPFTRELRDMGIPVFIGHAAGNISGATMVVRSSAIPEDNPEVQAARQAGIPVLKRAEFLETFLKKYRVIAVAGTHGKTTTTGMIAWMLSSLAQNPSYIIGGVVRDLHTNAHAGKSDLFVIEADEYDRMFLGLHPHIAVITYLEHDHPDCFPTMADYSGAFEDFIRQIQAGGILLVNGDHPPTRALGQATPKGVKVMTYGESEHNTYFLKHASVNRWGGFSADVWKQMPDGENRRLLHLALQVPGKHNLLNALAALAVADQLGLMLSPAAEALHLFHGTGRRFEVRGEANGVTLIDDYAHHPTEIRTTLAAARARYPERHIWAVWQPHTYSRTQALMEEFCQSFEDADAVVVLEIYAAREKNPGFSAREVVNRMKHPAAVFQPTLETAQEYLLNCLQPGDVVLVLSAGDADALNARLLDVLSQGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ8</accession>
    <name>E8MYQ8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="8">PRA-PH</shortName>
            <ecNumber evidence="8">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">hisE</name>
        <name evidence="9" type="ordered locus">ANT_23680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PRA-PH family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560760.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23680"/>
    <dbReference type="EnsemblBacteria" id="BAJ64394">
        <property type="protein sequence ID" value="BAJ64394"/>
        <property type="gene ID" value="ANT_23680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23680"/>
    <dbReference type="eggNOG" id="COG0140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123337_0_0_0"/>
    <dbReference type="OMA" id="FTHEKGE"/>
    <dbReference type="OrthoDB" id="2022633at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="95" mass="10760" checksum="3A7C74A5930BD30C" modified="2011-04-05" version="1">MNVRELYAIICERRDHPLPDSYTAKLLAQGEDEILKKIGEEAVEVILAGKAQGDQRLIEEIADLTYHTLVLLASRGLTPEQIADELEKRHRKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYR9</accession>
    <name>E8MYR9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUFU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560771.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64405">
        <property type="protein sequence ID" value="BAJ64405"/>
        <property type="gene ID" value="ANT_23790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23790"/>
    <dbReference type="eggNOG" id="COG4859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082045_0_0_0"/>
    <dbReference type="OMA" id="YWPVRLL"/>
    <dbReference type="OrthoDB" id="1944952at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUFU" evidence="2">
        <location>
            <begin position="66"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="247" mass="28988" checksum="C3586D48810E9069" modified="2011-04-05" version="1">MDDNSAPARKIESTPSGTPIYRYEPRSKPAERVVDYPDMEKIQQHVERFIGKVDMVYHEIISDLVHLDIFLVNPTPERNFFTLVTSGMSQRPMKAPPGAEKFQYAELMICLPSYWLLTDEALQDETFYWPIRQLKTLATFPHEYNTWLWFGHTIANGEPARPFARNTKFSGIILGLPVLSPQDFWTLEIAENKTVFFLSVIPLYKDEMEMKLKKGSEDLFERFDQQGVNELLNLKRPSVYKKRWWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYV5</accession>
    <name>E8MYV5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560796.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64441">
        <property type="protein sequence ID" value="BAJ64441"/>
        <property type="gene ID" value="ANT_24150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24150"/>
    <dbReference type="HOGENOM" id="CLU_2230870_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="105" mass="11331" checksum="29CAFAFEC2A896DD" modified="2011-04-05" version="1">MNKPIVVFLLLAGVLLVGLLAGELSGADRPVDPQPVSLKTQPATATRTPGWWNGVATWTPSPTADPTREVTETVEGRSTPTPQLDIPPVRTVEMPTPQPTWTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA3</accession>
    <name>E8MZA3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558644.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62246">
        <property type="protein sequence ID" value="BAJ62246"/>
        <property type="gene ID" value="ANT_02120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02120"/>
    <dbReference type="HOGENOM" id="CLU_1248493_0_0_0"/>
    <dbReference type="OrthoDB" id="2225175at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="221" mass="24002" checksum="E0163B977D90E66D" modified="2011-04-05" version="1">MNKLSIRASFSGMVIAGVASLMALALILFGIIHTVAGNTVTKDQGLNKGPTRIGDITVELLGGRQIKDQFQVEVCYTLPDERDWLISISPTDTLLRINDKDYTVSEAQMISREKGSNGQYNLRCEALLFPVQNVPAGTPFQITLSKISVSESEIFDCAALQKKIDAIQPGISIQCATQPHVSGFHAVSWPRGITQAEANALAHDIASDARKGSWIFKDVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH4</accession>
    <name>E8MZH4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_24960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560877.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24960"/>
    <dbReference type="EnsemblBacteria" id="BAJ64522">
        <property type="protein sequence ID" value="BAJ64522"/>
        <property type="gene ID" value="ANT_24960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24960"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_0"/>
    <dbReference type="OMA" id="VEPAYEF"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="581"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="759" mass="82975" checksum="450F1552C3D9F90C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI4</accession>
    <name>E8MZI4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">grpE</name>
        <name evidence="7" type="ordered locus">ANT_25060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25060"/>
    <dbReference type="EnsemblBacteria" id="BAJ64532">
        <property type="protein sequence ID" value="BAJ64532"/>
        <property type="gene ID" value="ANT_25060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25060"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_1_0"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="210" mass="24180" checksum="D784CB95448E69BB" modified="2011-04-05" version="1">MSKRSKTVKQEETKPEAESVVSETQPAASVDAEQVAQTAETAEREALKEEVEALRQRVKALEEYIRELEGKQKEYIEGWARERADFSNYKRRIEREQATLAQNITGEILKKYLLILDDMSRAMKMRPKDGEAASWADGIELIYRKLQSILDAEGIQRIPAEQEMFDPMRHEAITYEESPEHESGQIIEVLQDGYTLGDRVLRPARVRVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM2</accession>
    <name>E8MZM2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25440"/>
    <dbReference type="EnsemblBacteria" id="BAJ64570">
        <property type="protein sequence ID" value="BAJ64570"/>
        <property type="gene ID" value="ANT_25440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25440"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_0"/>
    <dbReference type="OMA" id="RHTGMHQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="298" mass="32764" checksum="F1E4C900C6CE128F" modified="2011-04-05" version="1">MESTKLTGKTILITGATDGIGKETARQLARLGAHILITGRNPQKVEATVLELRQSTGSPQIEGFVADLSSQEQILNLAHAIHERVPALHVLINNAGAIFMQRQTSVDGIEMTFALNHLGYFMLTLLLIDLLKNNAPSRIINVSSAAHRGARLDFNDLQNERAYQGWRVYSQSKLANLLFTYELARRLEDSGMTVNALHPGFVATRFGRSNGGLFDPLFRLFQFAAIPPEEGARTSVYLAASSEVEGVSGKYFEKCKAVPSSPESYEVSSAQRLWEVSLQMTGISEPEILQTRTMKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP6</accession>
    <name>E8MZP6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560949.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25680"/>
    <dbReference type="EnsemblBacteria" id="BAJ64594">
        <property type="protein sequence ID" value="BAJ64594"/>
        <property type="gene ID" value="ANT_25680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25680"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_1_1_0"/>
    <dbReference type="OMA" id="GFDSRVN"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="34415" checksum="07B667A41665C5C8" modified="2011-04-05" version="1">MPRKRVRIIFNPIANFGRSWAIASSLRPLLTELGGAEWTGTVYPTHAVELARQAGEDGVETIIAMGGDGTVHEIVNGLMQLPPEKRPVLAIVPVGTGNDFAHSLGISSDPEIALRQAFSAPTHAVDIAHIRDNRGHEEYWVNSLGIGFDAVINIRSRRIPVFQGFLVYFLALLQAVLLDYTPYHAHFRTDQEEWEENLLMTILGNGRREGGGFQIAPRASVRDGAIDFCAVRTIPRMMMFYTVPYFLKGTQESLSYVRSGQLRRLELHSDRPLFIHTDGEIYAAYHSTVRNLTVEAVPSAIRVVAPALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ9</accession>
    <name>E8MZQ9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_25810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25810"/>
    <dbReference type="EnsemblBacteria" id="BAJ64607">
        <property type="protein sequence ID" value="BAJ64607"/>
        <property type="gene ID" value="ANT_25810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25810"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410325_0_0_0"/>
    <dbReference type="OMA" id="WEGIYFD"/>
    <dbReference type="OrthoDB" id="131906at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="8">
        <location>
            <begin position="100"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="7">
        <location>
            <begin position="611"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="690" mass="79684" checksum="5624B2FF481FCA99" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS3</accession>
    <name>E8MZS3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560976.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25950"/>
    <dbReference type="EnsemblBacteria" id="BAJ64621">
        <property type="protein sequence ID" value="BAJ64621"/>
        <property type="gene ID" value="ANT_25950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25950"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709475_0_0_0"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="153" mass="17487" checksum="1F3D48149652F844" modified="2011-04-05" version="1">MLTSSLQETLILRPFQPQDQDAAKGLILDGLVEHWGFLDPTLNPDLNDIAHAYANGCFLTAWHGKTLIGTGAFLPVDEQTIQIVRMSVRKSHRRLGVGKHILEALLLEATRREYRRAILETTATWTEVIDFYLRCGFIITHHAEGDVYFERWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ0</accession>
    <name>E8MZZ0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thymidylate synthase complementing protein ThyX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558722.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02910"/>
    <dbReference type="EnsemblBacteria" id="BAJ62325">
        <property type="protein sequence ID" value="BAJ62325"/>
        <property type="gene ID" value="ANT_02910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02910"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024745_0_0_0"/>
    <dbReference type="OMA" id="MHRHRRC"/>
    <dbReference type="OrthoDB" id="809519at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="477" mass="54427" checksum="EBA865C1997929B8" modified="2011-04-05" version="1">MPLNRQVYLLDSMRLPPETIAVAFAKTSRSPQSFREIAAELTDEKSAEFHEKWVVGYGHASVAEHAVLHIAVENVSRLAVECLESNRLASYTEKSTRYQKWDAQAYCLPPELETHPLRALYEDTIGTLFETYQHLLEPVRQVIEQRLPRQDGESDSAYDRRIRSEYVDVCRFALPAAALANVGVTINARALEHALRKMLSHPLAEVRQMGEEIKQVALERLPTLIRYVEPVAYLEQTARDFTRRAETLSPVEDADWCRLLSWDAQGENRILAAALYRFGHMPFAQALQVVENAPAEERAHLTEMLLAGRGRHDIPLRELEYAYFTVDVLLDQGAYFELKRHRMMTQTAQRLSALHGYALPKAIVEAGMAETFRLAMRAAHRAYLRLSADLPEVASYVVPNAYNRRVLLHFNLRTALHWLALRSAPNAHFSMRRVAQRVAQELRNVLPALGRYLLVEEGETWQAIEARYFAATAESPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ8</accession>
    <name>E8MZZ8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_02990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558730.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02990"/>
    <dbReference type="EnsemblBacteria" id="BAJ62333">
        <property type="protein sequence ID" value="BAJ62333"/>
        <property type="gene ID" value="ANT_02990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02990"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_0_0"/>
    <dbReference type="OMA" id="WFSWQNT"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="350" mass="37318" checksum="81ADCDA5DF66CDE8" modified="2011-04-05" version="1">MPKLKIERYPAPLWVRPLIPIISIVVTFLLTSLVVLSLNKNPFEAFYYFLIVPLASQSSAIEVLVKSTPLLLTGAAVTFAFSAGYYNIGAEGQLLAGAIAAAGLGMVLQNVPPVLAIPIMIVGGFAAGMAYAAIPALLKTRLDVDEVVTTLLLNTVILFFISFLLNGVWRSPVSGWPQSPEIAESAIFPRLIPRTRLHLGFLLAWISIGAVWLVFRRTVLGLRMRAVGMGKEAARFAGVKVEQTMLTAALISGGIAGLAGVSEVAGIHYHLIEAISNNFGYTGIIVAMLGALNPLGVSLAALFLGLLDTGAQTVSRAMGIPIYLGNIVQSALLLITLAALVLQNYRIRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N063</accession>
    <name>E8N063_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558795.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03640"/>
    <dbReference type="EnsemblBacteria" id="BAJ62398">
        <property type="protein sequence ID" value="BAJ62398"/>
        <property type="gene ID" value="ANT_03640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03640"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071013_1_0_0"/>
    <dbReference type="OMA" id="ICYPIVE"/>
    <dbReference type="OrthoDB" id="1227281at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="255" mass="28761" checksum="2A4C5FA7B02F0B8B" modified="2011-04-05" version="1">MKAILAAGGEASIQDPLYPYTQGKPKALLEMAGKPMVQWVIDALNASSVVDSIVVVGLPPHTPLESRLPLRILPDHHGMLENFQAGARAIYEEERRDQMVLAVSADIPLIRGEMVDWVAQNTQDIEADVYYHIIERHVMETRFPQSKRTYLRIEGREYCGGDLNALRLKAVLEADSLWNAMVQARKNPLKQAQLIGWDILLLLLLGRLTIPEAERRFSRRLGLRARAISCPYAELGMDVDKPVQYELALRELSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N076</accession>
    <name>E8N076_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V4R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558808.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03770"/>
    <dbReference type="EnsemblBacteria" id="BAJ62411">
        <property type="protein sequence ID" value="BAJ62411"/>
        <property type="gene ID" value="ANT_03770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03770"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1282415_0_0_0"/>
    <dbReference type="OMA" id="TMKMKIV"/>
    <dbReference type="OrthoDB" id="1307286at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V4R" evidence="1">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="210" mass="23172" checksum="6DA44C652045DD70" modified="2011-04-05" version="1">MEPIPKSGLYYSNKMARLALLALEEVMGKNGLNAILNLANLSHLIDNLPPDNLNREFDFADFSMLNGALEEMYGPRGGRGLAKRAGRAVFMEGLRNFGALAGAGDLAFKILPLSTKLRIGIPAMAKIFSTTSDQYTTVEEKEDHFVYTIHKCPVCYGRHTDKPCCHIATGVILEGLRWVSGGHEFKVEEVRCIACGDPTCDFIIYKEPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I0</accession>
    <name>E8N0I0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative S9 family peptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_27030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561081.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27030"/>
    <dbReference type="EnsemblBacteria" id="BAJ64729">
        <property type="protein sequence ID" value="BAJ64729"/>
        <property type="gene ID" value="ANT_27030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27030"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_1_0"/>
    <dbReference type="OMA" id="DENHWIM"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="457"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="668" mass="76150" checksum="0192461C7C6E437C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J2</accession>
    <name>E8N0J2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64741">
        <property type="protein sequence ID" value="BAJ64741"/>
        <property type="gene ID" value="ANT_27150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27150"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_0"/>
    <dbReference type="OMA" id="ADTFRRN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="106"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="564" mass="64903" checksum="7D277CF9D4F4BB60" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R1</accession>
    <name>E8N0R1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_04220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558852.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04220"/>
    <dbReference type="EnsemblBacteria" id="BAJ62456">
        <property type="protein sequence ID" value="BAJ62456"/>
        <property type="gene ID" value="ANT_04220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04220"/>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929525_0_0_0"/>
    <dbReference type="OrthoDB" id="12313at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901663">
        <property type="term" value="P:quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="299" mass="32796" checksum="9E913BF5BB2026D9" modified="2011-04-05" version="1">MEPAETSTLSQHVLRIARPWALGFSLLTYALGGGVAHYLGVTIEWGRFLGGQLLVFILLLCGFFLFETFELPLESAVPAPGEKPRRLSRIQALRISVILLTGGAALTALWIAQGVLNTVAFLVLGISVLVMLALSVPPLRLANSAYRDLLWGILFVYLIPAFAFALQSGELHTLLGFITLPLIFLYLASSLALSLEHYASDLKQGRRNMLNRLGWERAVGVHHYLVLVGFLLFPLGSLMGIPRSLLFPGLLGLPVGLFQIWQLMRIAGGAPPRWRLLMITAAATLVVTLYDLNLALWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U2</accession>
    <name>E8N0U2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ATP-dependent Clp protease ATP-binding subunit ClpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_04530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558883.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62487">
        <property type="protein sequence ID" value="BAJ62487"/>
        <property type="gene ID" value="ANT_04530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04530"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_0"/>
    <dbReference type="OMA" id="IMQDGGD"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="839" mass="93596" checksum="C78497395A4F2378" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W3</accession>
    <name>E8N0W3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558904.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04740"/>
    <dbReference type="EnsemblBacteria" id="BAJ62508">
        <property type="protein sequence ID" value="BAJ62508"/>
        <property type="gene ID" value="ANT_04740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04740"/>
    <dbReference type="eggNOG" id="COG2461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026706_1_0_0"/>
    <dbReference type="OMA" id="LCHPPKS"/>
    <dbReference type="OrthoDB" id="565213at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007380">
        <property type="entry name" value="DUF438"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04282">
        <property type="entry name" value="DUF438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF438" evidence="2">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="91"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="416" mass="48496" checksum="74FA7A8B5C528BC1" modified="2011-04-05" version="1">MSELINNRQQRIEIMKSLIRQLHHGSSEEQVKHQLETMLAEADYSDVFLMEMQLIQEGIPAESIQQLCDTHTHVLKKFLDLQETPETIPGHPVHTFIQENRELTRTTARVRLLIRMLDKMRDEDDASSLMMQIHQALNDLMDVDKHYKRKEYLLFPIFERNNLPGPPTVMWGKHDEVRQALRTTLEGLHEVSQIIASEARAFCTFAVEPLLQAIDEMIYKEEKILFPTALNLLTEQEWYDIYLQSDEYGYCLYAPEFEWIPEGGVQQPEERPAAHNGRIQMPTGSLSLNELIGLFTTLPFDVTFVDRDDVVRYFSPGKERIFSRSRAVLGRKVQYCHPPKSVHIVNQILKDFKAGKQDVARFWINLHGKMVYICYYAVRDKEGQYLGTLEVTQDITEIQQLSGERRLLMYDTPHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W6</accession>
    <name>E8N0W6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558907.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04770"/>
    <dbReference type="EnsemblBacteria" id="BAJ62511">
        <property type="protein sequence ID" value="BAJ62511"/>
        <property type="gene ID" value="ANT_04770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04770"/>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301647_0_0_0"/>
    <dbReference type="OMA" id="HIMAGEV"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTAD" evidence="1">
        <location>
            <begin position="933"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1075" mass="122515" checksum="E3E2A5AC306B2C6D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y5</accession>
    <name>E8N0Y5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04960"/>
    <dbReference type="EnsemblBacteria" id="BAJ62530">
        <property type="protein sequence ID" value="BAJ62530"/>
        <property type="gene ID" value="ANT_04960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04960"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_0"/>
    <dbReference type="OMA" id="GAYKRSK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="323" mass="35383" checksum="9884AA496F994A53" modified="2011-04-05" version="1">MNVLVTGASGFIGGNLCRVLVQAGHRVRAFHRASSVLTLLEGLDVEHAVGDLTQPETVARAMEGIEVVFHAAAWMGSSDPGKLYAVTVEGTRTVLRCAREAGVRRVVHTSSVAALGVPEYRSPFPINENHTWNYRPERYPYGYAKYLAELEVQRAVAQGLDAVIVNPALVFGAGDVYRQSRSLLRQVAARRFPFSVEGGLNVVHLDDVIEGHLAALERGRTGERYILGGENLSLHAMLSLAASVVGVPPPTLVLPAGIVRAAAIPLNAFQRFLNLPVPVETLHLAGYYFYFDTTKARRELGIALERSARQAFADAWEWMRFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z2</accession>
    <name>E8N0Z2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_05030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558933.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05030"/>
    <dbReference type="EnsemblBacteria" id="BAJ62537">
        <property type="protein sequence ID" value="BAJ62537"/>
        <property type="gene ID" value="ANT_05030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05030"/>
    <dbReference type="eggNOG" id="COG4843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161155_0_0_0"/>
    <dbReference type="OMA" id="KLALGYI"/>
    <dbReference type="OrthoDB" id="1480783at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044035">
        <property type="entry name" value="DUF5698"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022930">
        <property type="entry name" value="UPF0316"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40060">
        <property type="entry name" value="PTHR40060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18955">
        <property type="entry name" value="DUF5698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5698" evidence="6">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="127" mass="13727" checksum="9BC1CE2D43E09A56" modified="2011-04-05" version="1">MESVLSLEVILTALMIFVMRVVDMSMDTLRILFVVRGKKLITWVLGFLQSLIFIVAVARVLGGDVHPLSVLAYAAGFATGNIVGMFIEDKMAIGHVRITIISTAAGSQIAQALRESGYAVTEIKMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N118</accession>
    <name>E8N118_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_05290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558959.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05290"/>
    <dbReference type="EnsemblBacteria" id="BAJ62563">
        <property type="protein sequence ID" value="BAJ62563"/>
        <property type="gene ID" value="ANT_05290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05290"/>
    <dbReference type="HOGENOM" id="CLU_2731158_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="71" mass="8122" checksum="753A12CF59956398" modified="2011-04-05" version="1">METSTDTQKKMELRRGVIVFAALAVLTVIEYFLGTHAAPTIFLWLIALLKAGLVIWFYMHIQRAFREEGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N170</accession>
    <name>E8N170_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561160.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27870"/>
    <dbReference type="EnsemblBacteria" id="BAJ64813">
        <property type="protein sequence ID" value="BAJ64813"/>
        <property type="gene ID" value="ANT_27870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27870"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_1_3_0"/>
    <dbReference type="OMA" id="GYPRVKG"/>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="166"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="287" mass="32976" checksum="EC563F48B9EAC0AD" modified="2011-04-05" version="1">MTTEQYAHPEVLVETEWLAQHLHDPNLRIVESDEDPLLYDTGHIPGAVKVDWFTTLQDPVRRDFINQQQFEALCSSLGIANDTTVIFYGDKNNWFACYAFWLFEYYGHEHLRILNGGRQKWLQEARPITREVPVYPPTDYRAKPPKRDIRAFREDVFRHIETGGALVDVRSPQEYTGELLHMPNYPQEGAMRGGHIQGAVNIPWAMAINPEDGTFKLPQALRDLYQGKGITPDREVIAYCRIGERSSHTWFVLKYLLGYPQVRNYDGSWTEWGNLVGAPIEKGAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C8</accession>
    <name>E8N1C8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561216.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28450"/>
    <dbReference type="EnsemblBacteria" id="BAJ64871">
        <property type="protein sequence ID" value="BAJ64871"/>
        <property type="gene ID" value="ANT_28450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28450"/>
    <dbReference type="eggNOG" id="COG1857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068035_0_0_0"/>
    <dbReference type="OMA" id="HEGDPVP"/>
    <dbReference type="OrthoDB" id="1098288at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013414">
        <property type="entry name" value="Cas7/Cst2/DevR_sub_I-B/Tneap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010154">
        <property type="entry name" value="CRISPR-assoc_Cas7/Cst2/DevR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02585">
        <property type="entry name" value="cas_Cst2_DevR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01875">
        <property type="entry name" value="cas_MJ0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="359" mass="39955" checksum="9833D9D7715D5B40" modified="2011-04-05" version="1">MSFVTGLLLIDAPASALNNLGNLPGSMTENVVGVKHIPTREGNYPYVSAQAFRYWLRTTLEQGNWGWKAAPVFRETKIAYTDANPILYWDDDLFGYMRAPSKKTEAANARESSGLVAEATPTADTVTRVSPFRVSTLVSIAPVRLVEDFGTMSRQEGDPVLHGHQFYRATLQGLLSLDLHAAGTFTYVQRTGYQNLDEERCKLAKAKGLEHLEQEKAYRLPLKERIARVRALLEGLAELSGGAKQALHYTDVSPDILVLAVTRGGNHIFGHIIGAQGERPVLNLPALREALDVNREDLLSDVYIGWVRGYLDAEREKLETALGEGGMLGDWNDRIHLIHPREACQRLAQELEAHPDWMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E7</accession>
    <name>E8N1E7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cellobiose phosphorylase</fullName>
            <ecNumber evidence="3">2.4.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561235.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64890">
        <property type="protein sequence ID" value="BAJ64890"/>
        <property type="gene ID" value="ANT_28640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28640"/>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019054_0_0_0"/>
    <dbReference type="OMA" id="YVYAQMI"/>
    <dbReference type="OrthoDB" id="136681at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047738">
        <property type="term" value="F:cellobiose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11754">
        <property type="entry name" value="GH94N_CBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037825">
        <property type="entry name" value="GH94N_CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="814" mass="92670" checksum="2216BCB0A7DE0AF9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I9</accession>
    <name>E8N1I9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558990.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62594">
        <property type="protein sequence ID" value="BAJ62594"/>
        <property type="gene ID" value="ANT_05600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05600"/>
    <dbReference type="eggNOG" id="COG5617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523559_0_0_0"/>
    <dbReference type="OMA" id="LIACIWA"/>
    <dbReference type="OrthoDB" id="2066577at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="501" mass="56260" checksum="A9A26A22A2403055" modified="2011-04-05" version="1">MKRWLAGLTLFLTLSALFAIAPYGAGVARDSVEYLATGMHVAQGRGFITFDGTPFRLWPPLYPLLLAGLSVFPLDPFLTGGWVNALLLGASVYLSGLLFMEIFPRRRWLGIWGAGLFGISRSMFPLSIHLLSDLLFMVLVLAFLWVVSSMSRTRGVLLAGVLAGLAWLDRYIGALLLPLGAGWVVFFSRVSWRKRLERMGLFLLVSALPMSFWMVRNLRLFGHPFGAPPPARLTLIENVEAGLAEMRLWLFPEGFLPAWGMLGGFLLFLGVLAFLVRWRRGDLAGRAGILAGWFILWGVAYFAFLLISSTQADITRLDARLMAPIYPAFLMFILAGLEGLARVLKRWRLASLLVPLIVGLFWGIPSVSQWADILQQTRTYGAPLYNYLNTPEFRQSGVTAYLQSEGVPEGLPLYSNYRTAVFLYTRHTCSGSPWSRHPHYAIEYPLEQYLPDFPAGETGVLIWYESGVHTHYYAPEDLARLYVLDVLYKGEDGGVYLIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N9</accession>
    <name>E8N1N9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559039.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62644">
        <property type="protein sequence ID" value="BAJ62644"/>
        <property type="gene ID" value="ANT_06100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06100"/>
    <dbReference type="HOGENOM" id="CLU_1718549_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="152" mass="18144" checksum="E3B30810D8349C5C" modified="2011-04-05" version="1">MEKNRLQPGFWRIVDNDYIATFSIYTIGTLWAVYLIFKVFALEFRDESFYLILSAVLTVLGGAVLAWRYWRIRAFFAKGERTRGKLVKTDFFRSTGWLEYDYTLKGKRYHRKETVHRNPRTRALKEGDLVWVVFDPQRPERAMLADIYEEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P6</accession>
    <name>E8N1P6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559046.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62651">
        <property type="protein sequence ID" value="BAJ62651"/>
        <property type="gene ID" value="ANT_06170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06170"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_0"/>
    <dbReference type="OMA" id="NKNYGQT"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="317" mass="35700" checksum="9531CFF58BE443E1" modified="2011-04-05" version="1">MDLSIVVPVYNEEENLPLLYQAVVAAVVPLNLEWELILVDDGSRDSSPQVLQTLAEQDPQHVRVVLLRRNFGQTAAIAAGIDHSSGEIVVLMDADLQNDPADIPMMLEKIHEGYDVVSGWRKNRQDDLTRTLPSRLANGLISRVTGVHLHDYGCTLKAYRREVLTGFRLYGEMHRFIPVYAHSVGARILEVEVHHHPRRFGKAKYGLERTAKVILDLFTVKFLSSYSNKPIYLFGGVGIILIGMAFLVLFYLFVRRVFFGISVLGSPLFQMSTMVAIFGFQSILMGLIAELLVRTYHESQGKPTYTVRTTINFPPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q5</accession>
    <name>E8N1Q5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative LytR family transcriptional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_06260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559055.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62660">
        <property type="protein sequence ID" value="BAJ62660"/>
        <property type="gene ID" value="ANT_06260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06260"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697642_0_0_0"/>
    <dbReference type="OMA" id="NGELALC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225395" evidence="3">
        <location>
            <begin position="27"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="106"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="395" mass="43326" checksum="25C1E9A849647E4E" modified="2011-04-05" version="1">MLKAVTPLYRLLVGLLLCALALSACGAEQDITARGTVFPSYAVQMPPTLSPTPSLTPLPPRSTVYPTPRFTSVTPIPSPAEPLTLPDEVMVYLLAGQDRSQPFVGRTDAIHLVFLHPRFAKAALISLAPDLFVYLPGYSMQRLSAAYPLGGARLLRETLAYNFGVRVDEWAVMRMDDFAFLVDELGGINVPVLEAIPGVCGDRIYPGQVFMNGELALCYARLRQQEQETARGLRQQALLEQMLLRLAQGGNLVRLPGIFETIAPRLDTSLSREDVVGRAALALRLSDTRRLGYFQIGENAARVWPILDNPRTIVFLPDGQAVRRVLEQAMAFISRPEAFSERIATLEFELTISPTPTPLPTDTPIPPDTPTPLPTFTRTPAPQTLTPTFTPTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N286</accession>
    <name>E8N286_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gidB</name>
        <name evidence="2" type="synonym">rsmG</name>
        <name evidence="3" type="ordered locus">ANT_30070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30070"/>
    <dbReference type="EnsemblBacteria" id="BAJ65033">
        <property type="protein sequence ID" value="BAJ65033"/>
        <property type="gene ID" value="ANT_30070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30070"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_0_0_0"/>
    <dbReference type="OMA" id="ICFPHLH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="27213" checksum="935A7D8CAFCCBCE9" modified="2011-04-05" version="1">MPAFMEDLVRYAASLFDLTLSARQVEALRIYEQELLEWNERMNLTAIRDVPGIRVKHFLDSFSCALAWRDNPPASLIDIGTGAGFPGIPLKILYPSMRLTLVDSVGKKVDFCRHVVQKLGLDRVEALQARAEELGQNPQYREKYDCAVARAVAQMNILAEYLLPLVRVGGIMLAQKGESGPSETHTAEGVIRLLGGNVRKLIPVELPGVVEERFLVVVDKVAVTPSAYPRRVGVPAKSPLDVKKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D3</accession>
    <name>E8N2D3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559133.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62739">
        <property type="protein sequence ID" value="BAJ62739"/>
        <property type="gene ID" value="ANT_07050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07050"/>
    <dbReference type="HOGENOM" id="CLU_181375_0_0_0"/>
    <dbReference type="OMA" id="GTDKITM"/>
    <dbReference type="OrthoDB" id="2091541at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="94" mass="10727" checksum="9A8B7456AFFC4951" modified="2011-04-05" version="1">MTFVPYRVLRNTPGELRKKLKEAGHLVVTGDGEPFAVMLSVEPGEVEQVLETILRLRAQQAVRRMRESAQERGLERLSEADIESEIRAVRKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H3</accession>
    <name>E8N2H3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ANT_07450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559172.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62779">
        <property type="protein sequence ID" value="BAJ62779"/>
        <property type="gene ID" value="ANT_07450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07450"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_0"/>
    <dbReference type="OMA" id="YLTMEDV"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="232"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="296"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ62779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="466" mass="51739" checksum="AD466B13FD898D96" modified="2011-04-05" version="1">MSILQIGLIFLLIALNAFFVGVEFAVVASRRSRLDLLVEPDHPALRLVHRWLEDEAARDRLIAASQLGITLVSLALGSVGEKAFEAWLEPYFAHWMLPPQLMFLRQAVEILPLVLSLTIVTGLHVVLGEQVPKVAVLRDPEAFALRAAQPMDLFARIFRGFIDLLDWATRTILKALGIPSNGHAHALISSVEELRQIVTSPEVEQLVDDSEREMLSAVIDFGERVVRQVVVPRTEIIAIEADQLLTEAAELAAREGVTKLPVYEDNLDQVIGILHMKDLMARWVEDRLENGCARDLAREALFVPDSLPINDLLMLFRERRQHIAIVLDEYGGTAGLVTLEDLLEEIVGDVQDAFDAEPPAIQSLKDGSALIDGMTLIEEVNETFGLHLQDPNYDTLAGYILGKLGHIPAVGEEVEDPENGISLRVEAMERLRIARVLMRRLPKPAPKPDPVPEKTSPLQTEPAHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H4</accession>
    <name>E8N2H4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559173.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07460"/>
    <dbReference type="EnsemblBacteria" id="BAJ62780">
        <property type="protein sequence ID" value="BAJ62780"/>
        <property type="gene ID" value="ANT_07460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07460"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_34_3_0"/>
    <dbReference type="OMA" id="RQTNVYR"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="145" mass="16128" checksum="34C9FC6AEA616E2C" modified="2011-04-05" version="1">MPIDVVKNVTDELLEAMQRLMPQLNPGHPIPDRQALERIVHSEASTLLVSRDESGRITGMLTLVVFHTPSGTHAWIEDVVVDSVSRGQGIGEALTRKAIEMAQALGADSVNLTSRPAREAANRLYQRVGFQLRQTNVYRYSLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2M6</accession>
    <name>E8N2M6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559224.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07980"/>
    <dbReference type="EnsemblBacteria" id="BAJ62832">
        <property type="protein sequence ID" value="BAJ62832"/>
        <property type="gene ID" value="ANT_07980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07980"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155955_1_0_0"/>
    <dbReference type="OMA" id="IVEAMGY"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="125" mass="14238" checksum="8E449DF402299BA8" modified="2011-04-05" version="1">MNLTGKENTTIEIILCFNEALNQGNVDGMMNLMSEDCIFENTSPAPDGSRYQGKTSVRLFWEQFFKASQNPKIEMEEIFACGDHAVMRWVYTWQDGTGTAFHIRGVDVYLIRDGRIAQKLSYVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P5</accession>
    <name>E8N2P5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_08170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559243.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62851">
        <property type="protein sequence ID" value="BAJ62851"/>
        <property type="gene ID" value="ANT_08170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08170"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_0_1_0"/>
    <dbReference type="OMA" id="WVPVFAM"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="401" mass="44554" checksum="E62601AB4297CD33" modified="2011-04-05" version="1">MKKILAIIWKDVLLRFSSPVEWLFFLILPVVFTVVLSLGTPNENSDNRSILLVVDEAKTPLSREILQQLEKSPVVRPIETSRQDAEQRFRERKTLFWMLIPEGVSEERLQSGESLPLTFYEQPNQITALAVRRSVQEAIRTVTQSLQAAQFAVEQAESIRPFENENQRLAYFQEAHRLAVQLQEATPERLMVLRENAPDSIPYDPRTNSSAGQLITWVFIPLFGISVLMVSERESRTLARLMTTPTSSGTFLAGTILGQVLMALVQMALLVGFGIIALKVPWGREPLGLAVVLTAGALAAAAFGTFLGTLVRSSSQANNLSIMLGMVMALLGGCWYPLELFPPAVQNVVKILPTTWAMQGMLDLTLRAGSVQDIWLEAGVLLGFAAVFFALGIWRFRKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Q4</accession>
    <name>E8N2Q4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_08260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559252.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62860">
        <property type="protein sequence ID" value="BAJ62860"/>
        <property type="gene ID" value="ANT_08260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08260"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_6_1_0"/>
    <dbReference type="OMA" id="GQIGMAF"/>
    <dbReference type="OrthoDB" id="791272at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="402" mass="43413" checksum="8D69E089D9EA5DB1" modified="2011-04-05" version="1">MSLSKPSSSNPNILFTLYFLMFAAGGIYFTYFLIFLRQSGLTSAQIGVINMSGGVVAFFASTLWGYLSDRTGKARLLLAFAIAANGAIALLYPLAHAFPAFLAIACVFAIFNAAIMTLMDSLALNLLGERRHEYGKYRLGGTFGYISTTLTIGFLFERIGLRWMFPIYFLIMLLYALLATRLPDSSTGASRSSLPSLKALGTLLRQPGWGVFLATTFLIWLASSGAISFLGIKLKGMGASDSLVGVVASAAAIFEIPFMLYSGQIMRKLGIPRTLWFAIIGYIARVFLYTVIPTPEWAIAVNGLNGVSYVLYWNAALQFNNQNAPENLKATAQGILVSTMNLASVASALLTGGLYDAIGADPVYSLLAGICVLALILFTLGNRRLVFPPRTEAEPLAQADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S7</accession>
    <name>E8N2S7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30510"/>
    <dbReference type="EnsemblBacteria" id="BAJ65077">
        <property type="protein sequence ID" value="BAJ65077"/>
        <property type="gene ID" value="ANT_30510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30510"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046120_1_1_0"/>
    <dbReference type="OMA" id="QPRNMSM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="278" mass="31477" checksum="E52DD62C9A2F7068" modified="2011-04-05" version="1">MMTSNFIVDVNEADFEFEVIAYSQNTPVLVDFWASWCQPCRHLTPLLEGLANEMQGAFRLARVNVDENPNLALRYGVRSIPTVKAFVQGQVVAEFVGLQPEARIREFIQRLMPPSPAALALEKAYSLLAEQQWEDAETIFRDLEDQEGLRPAVQLGLLKSVLAQGRGGEAALILRDFPASREFPIAEKMRPLVEALVQFERGELPNETDLDATFINAIRLARRGNLEAAMDGLLDILRQDKRYRNDLARQVMLGILELYDPNDPTARQYRNELGMVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S9</accession>
    <name>E8N2S9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30530"/>
    <dbReference type="EnsemblBacteria" id="BAJ65079">
        <property type="protein sequence ID" value="BAJ65079"/>
        <property type="gene ID" value="ANT_30530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30530"/>
    <dbReference type="HOGENOM" id="CLU_570676_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="478" mass="52391" checksum="189F7F52CBBB94F1" modified="2011-04-05" version="1">MNRRIFIVAILGGLAGNVLAYSALGAFLPQEIFHIKPSAFIAYVCLAGLVVLWFLCGWLAGWMSGASTRRQAMGAGALTGGIAALMVNGSFGELIAGLVGTTALLNAQILPAINEADVILRVSDTANTILLYNYISIWAAIFLGVFFGALGGWLGGALSKPSRSHAFFWQGILVSLLPLFTLLSFGVLRLYFTRMKELSNGEQNLLAISFGLHFLFLIFLHFAGWRLLKATPYTSQIPSLKTALSTFFCLALAIPATLAFMTFTNHFSISFACILLIVIVVFIGATQVVKNYRKNESQEENPRKGWLRTFLSWLGNIGEPRLLGIYFLFFALLTLLGIFLVMREALLQVIWLIAGMLLILTFAILAFRAGWQARSQEAPHVSWIEYSISASTASFLSSLWMGLNISPAFALTFLSLSFMEQGASENLVITADAQGVVNSYFNIMPSFILFWSITAVISGILAFLVGWLLRRPQNQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z0</accession>
    <name>E8N2Z0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561481.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31140"/>
    <dbReference type="EnsemblBacteria" id="BAJ65140">
        <property type="protein sequence ID" value="BAJ65140"/>
        <property type="gene ID" value="ANT_31140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31140"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017083_0_0_0"/>
    <dbReference type="OMA" id="TNMLAVS"/>
    <dbReference type="OrthoDB" id="383378at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="178"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="421"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="625" mass="65703" checksum="85071B24B386D444" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N318</accession>
    <name>E8N318_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561509.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31420"/>
    <dbReference type="EnsemblBacteria" id="BAJ65168">
        <property type="protein sequence ID" value="BAJ65168"/>
        <property type="gene ID" value="ANT_31420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31420"/>
    <dbReference type="HOGENOM" id="CLU_1500554_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228605" evidence="1">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19838" checksum="AD494CEBEABCA435" modified="2011-04-05" version="1">MKFKVFSIAIVFLLAFGVLMMQTAPVAAQSSAPEGGVRDKINQMREGVLERTYQRELNWLAAQEDHLNNARTFASKGRELMEKARQKGLDVSALEQAFNTFDSAITAAQGHHDRAAAVLNTHAGFDNNGKATDPQAAKQTVEQAYRALSDAHLTLQKGVIEMRQALRAWRDAHRPQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N322</accession>
    <name>E8N322_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31460"/>
    <dbReference type="EnsemblBacteria" id="BAJ65172">
        <property type="protein sequence ID" value="BAJ65172"/>
        <property type="gene ID" value="ANT_31460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31460"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_4_0"/>
    <dbReference type="OMA" id="SHEPVIL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="213"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="395" mass="45073" checksum="7953D7034F00322C" modified="2011-04-05" version="1">MERLNMKVLIITTAFPRWMGDGRGNFVYEAAQAIKRQGCQVRVIAMHNPGAKTHEWMDGIEVIRPRYLPERWEILAKDSAGLPQAWRTNPWAKLALLPFLVVHTLNVLRYAPQADILHANWTLSGMVAWLTQRLHRKPYVVTVQGSDVFQGLKIPLVRQLSLWALKHARFVFALSHALAREVQELGIQADQIKIVPNGVNLGSIRNILQEESSHEPVILFVGSLFWRKGVTHLLEAFHQICGEIPGYRLVFVGEGDQREILEQRTRETGLENRVVFTGNLPHDDVIRWMRLARVFVLPSVEEGQGVVLLEAMACGTPCVGSNVGGIPDIVTPECGWLFEPENVQELASTLRNSILQKEEWEEKSYNSRNRVENIYDWDKIAFSILRYYQDAKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N342</accession>
    <name>E8N342_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T5orf172 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561532.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31680"/>
    <dbReference type="REBASE" id="32161">
        <property type="entry name" value="AthUNI1ORF31680P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65192">
        <property type="protein sequence ID" value="BAJ65192"/>
        <property type="gene ID" value="ANT_31680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31680"/>
    <dbReference type="eggNOG" id="COG4096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014749_0_0_0"/>
    <dbReference type="OMA" id="FNSALMN"/>
    <dbReference type="OrthoDB" id="50774at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T5orf172" evidence="1">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="848" mass="97881" checksum="D3561557A516DA2B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N371</accession>
    <name>E8N371_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_08510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559277.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62885">
        <property type="protein sequence ID" value="BAJ62885"/>
        <property type="gene ID" value="ANT_08510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08510"/>
    <dbReference type="eggNOG" id="COG2094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060471_3_0_0"/>
    <dbReference type="OMA" id="VEAYHHT"/>
    <dbReference type="OrthoDB" id="1385409at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="197" mass="22609" checksum="4F7C319F3B1D666C" modified="2011-04-05" version="1">MSDQALPVEFYDRNTLDVARSLLGMRLIRKFDSIRLVGIITETEAYRGEEDLACHARAGLTPRTRVMFGRAGHAYVYFTYGMHWLLNVVTEREGFPAAVLIRAVRVVEGEAWIRERRKGVPPKNWTDGPAKLCRAFEIDGKLNGADLTVTENGLWIARGQDIPEEYIERTARIGIDSVPEPWRSIPWRFRARDEFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N377</accession>
    <name>E8N377_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559283.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08570"/>
    <dbReference type="EnsemblBacteria" id="BAJ62891">
        <property type="protein sequence ID" value="BAJ62891"/>
        <property type="gene ID" value="ANT_08570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08570"/>
    <dbReference type="eggNOG" id="COG3304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1843608_0_0_0"/>
    <dbReference type="OMA" id="VFVGWWA"/>
    <dbReference type="OrthoDB" id="1806532at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="143" mass="16598" checksum="F45B06F90EDDE6BB" modified="2011-04-05" version="1">MSYEPVVVETRRNPGCLIQLLWFAFIGWWLGQAWMIVAWLFMISILGIPIGIVMLNMLPKVIALREPAREVAVYRRADGTLVKSEVEPRQLPFLLRALYFILIGWWFSALWMEVAYLLCATIIGLPLGFWMFDRIPAVLTLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N389</accession>
    <name>E8N389_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08690"/>
    <dbReference type="EnsemblBacteria" id="BAJ62903">
        <property type="protein sequence ID" value="BAJ62903"/>
        <property type="gene ID" value="ANT_08690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08690"/>
    <dbReference type="eggNOG" id="COG5624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538396_0_0_0"/>
    <dbReference type="OMA" id="YYQVLWT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="532" mass="58048" checksum="6E4D32FB90868361" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B6</accession>
    <name>E8N3B6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NagC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08960"/>
    <dbReference type="EnsemblBacteria" id="BAJ62930">
        <property type="protein sequence ID" value="BAJ62930"/>
        <property type="gene ID" value="ANT_08960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08960"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_5_0"/>
    <dbReference type="OMA" id="DFVLLWN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="397" mass="42085" checksum="07C64C39F7D08322" modified="2011-04-05" version="1">MRTIATITANEMRAINRSAVLEVIRQYAPISRVEVANRLGVSLPTVMRLVDDLLAEDLIRPSQTSVSTGGRRGELLEFNASGHLVVGVDLGGTKIHGAITDLAGNILHEVNVTGHMTHGEDSYSLLVNLLENLSSIAASSGKHLLGLGVGVPGVVHPESGEVSLAPALNWNDFPLRPRLERYFGLPVVVENDVNLAALGELWFGAGQDANTLVLITVGTGIGAGVIVNGCLYAGTHFMAGEVGYLVPDRTFLGKPLEGFGALERLASGTGIAERARQRLKAVRPVEALESLTAEDVFEAARAGECWATEVVDETVDYLAQAIAAIQLVIDPEVILLGGGVSNSADLLIEPILQRLAGVIPVQPALLPSRLGYRAGVLGAMVKLLRVTANYYLLQKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F1</accession>
    <name>E8N3F1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_09310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559356.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09310"/>
    <dbReference type="EnsemblBacteria" id="BAJ62965">
        <property type="protein sequence ID" value="BAJ62965"/>
        <property type="gene ID" value="ANT_09310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09310"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="VCMSKLR"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="234" mass="26081" checksum="073936BB585C9B9A" modified="2011-04-05" version="1">MSKSILLIDDDALMRRSLGFNLEQAGFQVFTAASAEDGLVLAKRTPPDLVLLDINLPGMDGLDALRRFREEVGAPVIFVTARRRELDQVLGLELGADDYITKPFDFNILLARIKAVLRRVSGGEERKPAEPQPLLIGELRIDPLAHTVHRAGKPVDLSPREFDLLYTLALEAGKVVPADELLARVWGAEFVGEPQVLYVHIRWLREKLEDDPQNPHYILTVRGVGYKLVGGEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L9</accession>
    <name>E8N3L9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsL</name>
        <name evidence="7" type="ordered locus">ANT_09990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559424.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63033">
        <property type="protein sequence ID" value="BAJ63033"/>
        <property type="gene ID" value="ANT_09990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09990"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_0"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="15467" checksum="4E182F6619E2070B" modified="2011-04-05" version="1">MPTINQLIRKGRESKKVKSKAPALQYILNIPKQRRLRQEGGSPQKRGVCTVVRTMTPKKPNSALRKIARVRLTNGIEVTAYIPGEGHQLQEHSVVLVRGGRVKDLPGVRYHIVRGTLDTTGVAKRRQGRSKYGAKRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M8</accession>
    <name>E8N3M8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsS</name>
        <name evidence="7" type="ordered locus">ANT_10080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559433.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10080"/>
    <dbReference type="EnsemblBacteria" id="BAJ63042">
        <property type="protein sequence ID" value="BAJ63042"/>
        <property type="gene ID" value="ANT_10080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10080"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_0"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="97" mass="10878" checksum="41F6C43FD0BECA28" modified="2011-04-05" version="1">MSRSLKKGPYVDPKLLKKIELMNTRGEKKVIRTWSRASVIFPQMVGHTIAVHDGRRHVPIYITENMVGHRLGEFAPTRLFRGHVAEKSSGAKGKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N1</accession>
    <name>E8N3N1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplP</name>
        <name evidence="9" type="ordered locus">ANT_10110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559436.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63045">
        <property type="protein sequence ID" value="BAJ63045"/>
        <property type="gene ID" value="ANT_10110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10110"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_0"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="142" mass="16420" checksum="036BCD2902F602F8" modified="2011-04-05" version="1">MLMPKRVKWRKQQRGNMRGKALRGAEIAFGEYALQALEPGWVSARQIEAARRAIVREMRRRGKIWIRIFPDKPYTHRPPETRMGKGKGNVEYWVAVVRPGRIMFEVGGLPEEVAKEALRQASYKFSIKTKVIAREEVEGEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3R9</accession>
    <name>E8N3R9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_10490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559473.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10490"/>
    <dbReference type="EnsemblBacteria" id="BAJ63083">
        <property type="protein sequence ID" value="BAJ63083"/>
        <property type="gene ID" value="ANT_10490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10490"/>
    <dbReference type="eggNOG" id="ENOG502Z91J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392645_0_0_0"/>
    <dbReference type="OMA" id="PIWEPGV"/>
    <dbReference type="OrthoDB" id="125670at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="697" mass="81142" checksum="24DA6F8581C1D1DE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V9</accession>
    <name>E8N3V9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559513.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63123">
        <property type="protein sequence ID" value="BAJ63123"/>
        <property type="gene ID" value="ANT_10890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10890"/>
    <dbReference type="eggNOG" id="COG2316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090635_1_1_0"/>
    <dbReference type="OMA" id="EMLGWEL"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="193" mass="21529" checksum="5B6E15069C13ECC4" modified="2011-04-05" version="1">MMNREEALRIVHTYVKNPNLINHMLSVEAAMRFYAEKYGEDAELWGVVGLLHDFDWEIHPTLEEHPIAGAPILREHGVPEEIVRAILSHADHTGIPRTTLMEKALYACDEVTGLITAVALVRPSRSLYDLTSSSVKKKWKDRAFAAGANREEIAAGAQELGIDLWEHVDNVILAMRRIAPELGLEGNIESPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X5</accession>
    <name>E8N3X5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ordered locus">ANT_11050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559529.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63139">
        <property type="protein sequence ID" value="BAJ63139"/>
        <property type="gene ID" value="ANT_11050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11050"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_1_0"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="46620" checksum="33B579D95660B565" modified="2011-04-05" version="1">MEKFIIDGGIPLHGEVTPGGNKNAALPLLAACLLTTEPVILHNVPSILDVIHMRRLLQSLGVEFTELDAHTWKIQAREVRPADLDPDLCRKIRASILLAGPMTARTGELHLPPPGGDVIGRRRVDTHMLALTRLGAEVNYDRTFHFRARDGLKGADILLDQASVTGTENAIMAAVLAKGHTVIRNAASEPHVQELCHFLNKLGAKIENIGSNTLHIEGVPSLSGGEFTIGPDYLEVVSFIGAAVVTHGSIRIRNAGPEYLDMIRYVMGRMGVEWEVEGQDILVPAEQRLEVEPDLGGAIPEISVMPWPAFPTDLMSIAIVVATQARGSILFHDWMYPSRMFFTDKLVGMGAQIVLCDPHRCIVQGPSQLYGEKMESPDIRAGMALLLAALSAQGRSVIRNVGQIDRGYEKVDVKLKALGASIERQSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N408</accession>
    <name>E8N408_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559560.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63172">
        <property type="protein sequence ID" value="BAJ63172"/>
        <property type="gene ID" value="ANT_11380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11380"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131367_1_1_0"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="17246" checksum="B2463363BD26CB88" modified="2011-04-05" version="1">MIAIVFLILRLVLVVLLYAFLLWALYTLWNDLRMQTLALQAPQIPPITLEVTNLMDEQPATFDLPEILVGRSASANYTIRNETVSSQHARLSYHHHQWWVEDLKSTNGTFLNGERVVSPTVVMNGDELRCGQVNIRVTVHEPQKQQVRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N431</accession>
    <name>E8N431_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559583.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11610"/>
    <dbReference type="EnsemblBacteria" id="BAJ63195">
        <property type="protein sequence ID" value="BAJ63195"/>
        <property type="gene ID" value="ANT_11610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11610"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472605_0_0_0"/>
    <dbReference type="OMA" id="GGHIERN"/>
    <dbReference type="OrthoDB" id="1957197at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="176" mass="20086" checksum="A2D6AEA3A66DEF36" modified="2011-04-05" version="1">MPASDQGVHLPRYKVIPRTLIFLVHGEEILLIRGAPTKRLWANRYNGLGGHVEHGEDPLSAAKRELREEAGVENVRLHGIGVLMVDVQADTGVCIFVFRGEVREKFSWQSEEGTLEWVSWKDVQKLPLVEDLPQILPRVLAWQQGDPPFWAISRYENEQLMVHFHSEEGDSSLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N438</accession>
    <name>E8N438_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559590.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63202">
        <property type="protein sequence ID" value="BAJ63202"/>
        <property type="gene ID" value="ANT_11680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11680"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506849_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="2">
        <location>
            <begin position="95"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="537" mass="59658" checksum="AE2C45073FBAC50D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N487</accession>
    <name>E8N487_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_12170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559639.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12170"/>
    <dbReference type="EnsemblBacteria" id="BAJ63251">
        <property type="protein sequence ID" value="BAJ63251"/>
        <property type="gene ID" value="ANT_12170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12170"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="QVHKYYG"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="248" mass="27830" checksum="90BA7C61CEE4CCDA" modified="2011-04-05" version="1">MASTDDIIIVKNVSKFFGKVQALRNVSLTVKRGSVVVLIGPSGSGKSTLLRCMNHMEIEDEGEIWVDGQRLSRDEKIINQVRADIGMVFQHFNLYPHLTVLQNITLAQRIVRKRSQEEAETIAMEQLKRVGIAEKAHNYPAQLSGGQQQRVAIARALAMKPKILLFDEPTSALDPEMIKEVLDVMLDLAKAGITMVVATHEMGFARAAADEVHFMDEGCIVESGTPEMVFDHPRFERTRQFLSQILFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B7</accession>
    <name>E8N4B7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative alpha-L-fucosidase</fullName>
            <ecNumber evidence="6">3.2.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_12470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559669.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63281">
        <property type="protein sequence ID" value="BAJ63281"/>
        <property type="gene ID" value="ANT_12470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12470"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_2_0"/>
    <dbReference type="OMA" id="RSIYGCT"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="419" mass="48542" checksum="ED3B8A260384746C" modified="2011-04-05" version="1">MDKDRIRWFIDARFGMFIHWGIYAIPARGEWVKHFESIPEAQYQQYFETFNPIHYNPREWARIARQSGMKYAVMTTKHHDGFCLFDSQFTDYKATNTPAGRDLIKEYVDAFRAEGLRVGFYYSLLDWHHPDYPVAGDRFHPYRNFPEFSECKGNLERYALYVHNQVEELLTSYGKIDIIWFDFSYDDMRGEAWKATELVNMVRSLQPEILIDNRLGGNIRARQPEVYAGDFASPEQIIPPEGVTNEDGEPIPWEACITLNDHWGYHAQDLNWKSPRTIVRTLVECVSKGGNLLLNVGPNAKGEIPEASVRILSEVGQWMRRNGESIYGCGRAPFPKPEWGRWTAKEGRLYAHLLDRGIGPVNLRGLEGKIAYARLLADGSEVRLERPWNAAEYPEDAFISFSQPELPDDWDTVVELMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D3</accession>
    <name>E8N4D3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prs</name>
        <name evidence="4" type="ordered locus">ANT_12630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12630"/>
    <dbReference type="EnsemblBacteria" id="BAJ63297">
        <property type="protein sequence ID" value="BAJ63297"/>
        <property type="gene ID" value="ANT_12630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12630"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_0"/>
    <dbReference type="OMA" id="HYAYARS"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="34974" checksum="39454906F6A009FA" modified="2011-04-05" version="1">MYGDIKLYAGSASIELTNKVAEYLGVPVNGRDVVVFPNENIFVKLHSSVRGQDCYVIQTTSAPVHRNLMELLIMIQTLRLDSAARITAVIPYLCYARSDKKDQPRVPITARLVADMIEVAGADRYITLDLHAGQIQGFFTIPGDVLTAFHILVDYLHSIKPRMHSPVLVTADLGFAKKGRNFAAAIDAPMAFIEKRRVANDAKARALTIIGDVNGRDCVLVDDEIDTGGTMVEAVNILKENGARNVYMVFVHPVFSANAAQRLASLPVTEFITTDSIPIPPEKKALFGERLKILSVAPLLGEVILRANQGRSVGEMFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F9</accession>
    <name>E8N4F9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_12890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63323">
        <property type="protein sequence ID" value="BAJ63323"/>
        <property type="gene ID" value="ANT_12890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12890"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_0"/>
    <dbReference type="OMA" id="NMGWFLI"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="375" mass="40676" checksum="FF40585265BF246E" modified="2011-04-05" version="1">MNRSEPMSKTPSLFESLVQQRTLGYLLLGLILLVAIWRLGNALLENPSLFLQQVTNGLQIGFVYALIALGYTMVYGIVRLINFAHGDVFMVGAFTSFYAISRMQLHLWPRVLFPNLNPFLGDAIGTVTVVLLSMVVCALLAVTIERVAYKPLRNAPRISALITAIGVSFFLEYFGALNFVYTANYITYRRPFDVVTWVIGNQGVQVLQRGQEVPPGAIIFSNISFIIIIVSIILLVLLQYFVKNTRTGKAMRATAYDRQTARLMGVDVDATISTTFAIGAALAGAAGVLYAIAYPQVVFWMGIIPGLKAFVAAVLGGIGSIPGAVVGALILGQAETLSAAYISTPMRDAIAFSILIIVLLVRPTGIFGEAQREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U8</accession>
    <name>E8N4U8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559844.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63462">
        <property type="protein sequence ID" value="BAJ63462"/>
        <property type="gene ID" value="ANT_14340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14340"/>
    <dbReference type="eggNOG" id="COG1480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015767_1_1_0"/>
    <dbReference type="OMA" id="QGTYNHS"/>
    <dbReference type="OrthoDB" id="1124669at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="2">
        <location>
            <begin position="478"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="711" mass="79618" checksum="0CC0C2E914B594BC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V0</accession>
    <name>E8N4V0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative competence protein comEA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comEA</name>
        <name evidence="3" type="ordered locus">ANT_14360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559846.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14360"/>
    <dbReference type="EnsemblBacteria" id="BAJ63464">
        <property type="protein sequence ID" value="BAJ63464"/>
        <property type="gene ID" value="ANT_14360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14360"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_1_0_0"/>
    <dbReference type="OMA" id="SESHIVM"/>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="184" mass="20293" checksum="D72EA5ECB0CA369A" modified="2011-04-05" version="1">MEEWQDWQKYLVAFFFGLIASAVILLIARRPTGIPLTLYPPPTPQPYQVHVDGAVNSPGVYTLERGSRVHDAVKAAGGTTESANLREINLAAPVKDGQKIYIPSMDETPIPSGTKQGDKPLVDLNHASFEELMTLPGIGEDRAREIIQYRESHGGFSELEELMNISGIGEATFEKIKPFIFITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V9</accession>
    <name>E8N4V9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559855.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14450"/>
    <dbReference type="EnsemblBacteria" id="BAJ63473">
        <property type="protein sequence ID" value="BAJ63473"/>
        <property type="gene ID" value="ANT_14450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14450"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_3_0"/>
    <dbReference type="OMA" id="VCWAAEA"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="37123" checksum="DDE85701FB221DE0" modified="2011-04-05" version="1">MKQRVALYLQDAHDLRAGLDYVRYAEVRGFEAVWQAESRLVRDAIVPMAAYAAVTERIKVGSGVINNWTRNIGLLAATFLTLDDLAPNRIICGIGAWWDPLAKNVGIERKKPLVAMRETVTVLRRLLNMERVTFHGEFVHVDGIELDVVHGRREPRNVPIMIGATGDQMMELTGEIADGVVLNYCVPPEYNLKALELLEKGARKAGRTLDDLDRPQLVVCSVDYDHDKAIDTTRELLTQYLAQQPHIAKASGVSMDVVSEIQSILGWPATHEQIQRAKHLVPEDLIHRITASGTPDEARAKVEEYRRNGCTCPILYPVGGDVRLLIDTFAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X2</accession>
    <name>E8N4X2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_14580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14580"/>
    <dbReference type="MEROPS" id="A24.019"/>
    <dbReference type="EnsemblBacteria" id="BAJ63486">
        <property type="protein sequence ID" value="BAJ63486"/>
        <property type="gene ID" value="ANT_14580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14580"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114217_0_0_0"/>
    <dbReference type="OMA" id="WITQLAT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="108"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="28621" checksum="6CDA8440C3293376" modified="2011-04-05" version="1">MKILSRNFGISMNAMITSLLIFFSGWLAGGLVNWLADWLPVESRLGGLICSSCRKEISWLDYWTLFPCKHCGRTRGLRTWLLHFGLGIAFLGVHWTGSPRLSEVEAMLWLTYSSLIVVIDFEHRLILEKTSIAGGILAFVIGVRLHGIGMTLAGGTAGAALLFLLFLGGEVFRRWMEKRRGEPISEVAMGFGDVILSGIIGLILGWPGILAGLFLAILAGGIVSGLIMFSMIIRKNYQAFTAIPYGPYLIFATLYLLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y0</accession>
    <name>E8N4Y0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent butanol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559876.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63494">
        <property type="protein sequence ID" value="BAJ63494"/>
        <property type="gene ID" value="ANT_14660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14660"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_0"/>
    <dbReference type="OMA" id="HAMSHQV"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="388" mass="43276" checksum="7B9BBBB1C6BD3140" modified="2011-04-05" version="1">MWFFQSPQIVYGEGSLSHLSQISGVRVLIVSDRTLERLGMVEKIRALLRENRFQVETFLDVESDPSVTTVENGAHKMREFEPDWIIALGGGSVMDATKAMWVLYERPDMDPVAINPIEPIFLRKKARMIAIPTTAGTGAEATWAIVLSEKESHRKLGLGNRECVPDLAILDPELTIGLPPRITADTGLDALTHAIEGYTSTWHNDFSDGLCLQAIRLIFNYLPRVYRDGNDREARERMQNAATIAGLGFGNAMAALAHGMGHALGARFNVPHGRAVALFLPYTIAYYVRGEAKTRYREIAQFLGENVQTENEAADWLIQKIRALESEVEQPLSIAQLGIDEKAFEEDLETLVAFALNDSQTLMGTRVPEVDELTRLFRVAYHGDDVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y7</accession>
    <name>E8N4Y7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">iscS</name>
        <name evidence="10" type="ordered locus">ANT_14730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559883.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63501">
        <property type="protein sequence ID" value="BAJ63501"/>
        <property type="gene ID" value="ANT_14730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14730"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_0"/>
    <dbReference type="OMA" id="APHIINF"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="7"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="384" mass="41709" checksum="B746294412CBAC17" modified="2011-04-05" version="1">MTQKHFYLDYAATTPLDPAVLEKMLPYFSEQFGNPSSVHSWGQQAENALETARETVASCLSAEASEIVFTSCGTESDNLALRGVARAQRSLHGKHHILTTPVEHHAVSHTAFDLAKVEGFEVELLPVDSTGMVDPDEVARRIRKDTAIVSVIYANNEIGTINPIAEIGKICREKGVPFHTDAVQAAAHLRMDVQRDFVDLLSIGAHKFYGPKGVGALYIRKGIPIQAVQTGGKQENYLRAGTHNVPYIVGLAEALKIAQTEPEKRAQHFQSMRDSLIHEVLSRIPGSQLTGHPSRRLPNHASFVFDGVDGNALLMMLDVQGFACSSGSACKTGSPQPSEVLLVLGIPAKLALSSLRVTLGRDTTSEALSLFVEALERCVAQQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N545</accession>
    <name>E8N545_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent protease La</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559941.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63559">
        <property type="protein sequence ID" value="BAJ63559"/>
        <property type="gene ID" value="ANT_15310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15310"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_3_1_0"/>
    <dbReference type="OMA" id="QANDETM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="40"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="349" mass="40115" checksum="0BF4DD4947F3DFDD" modified="2011-04-05" version="1">MKENWSDSDAEEFANHLHQRTEELYNIPDAEPDDEGLIECSAFIMQDMVIFPRMISPVFILPGPNMVAVLDAQANDETMIAMFLQNPDAEVPTLEDFLPIGVEIAVGRLLSLSDGKSSALIQGRRRVEIVEIVQDDPYLRVRARPIYESIEVNREIDALMRTSRDLFEKCVQLDRSLPDEAHIYSLNIPEPGWLADMIATAISFPLKERQTLLLLADPKERLKRLNWLLAQELDVLQLEDEIQSKVQNEVDRSQREFYLREQMKAIQTELGEGDIWMRDIAELRERIEKAGLPEEARKVAEKEVERLAQMPSMAPEVGIIRTYVEWILENYPGISKLKIISTLNTPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N552</accession>
    <name>E8N552_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559948.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63566">
        <property type="protein sequence ID" value="BAJ63566"/>
        <property type="gene ID" value="ANT_15380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15380"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131754_0_0_0"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228642" description="YceI domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="80"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="27177" checksum="345326B9A42C6EDA" modified="2011-04-05" version="1">MKKITGCLLFLVSFMVLITGCVSGSSSSQVNSTLPVLTSTPVVQTPVIEEYLPATTAENNTGKDRFPVKFVIDSQNSVISYTVDETFLNQNNRLATAVGKTSEITGELEIDLRNPSNISFGEFVVNIQTLRSDSSRRDSAIQNRWLESAKFPLARFNVREVKDFPQDPKENETIKFQIIGELTIRETTRPVTWDVSAMLKGDQILGKATTFIYMADWGIEPPSIAGVLTVKDGVTLNLEFAFLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N592</accession>
    <name>E8N592_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559987.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63606">
        <property type="protein sequence ID" value="BAJ63606"/>
        <property type="gene ID" value="ANT_15780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15780"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_2_0"/>
    <dbReference type="OMA" id="YRQFYFR"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="266"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="544" mass="62646" checksum="0CE9171BA41A3F5C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B5</accession>
    <name>E8N5B5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">ANT_16030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560009.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63629">
        <property type="protein sequence ID" value="BAJ63629"/>
        <property type="gene ID" value="ANT_16030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16030"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_1_0"/>
    <dbReference type="OMA" id="AVKMDKR"/>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="79" mass="8748" checksum="47A1EAB46EDAA3F5" modified="2011-04-05" version="1">MKDLIEYIARSLVDQVDKVEVTQQKGPGGKIKFELRVAREDMGRVIGKGGKVANAMRVLLRVAAARDEKQATLDVIEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C1</accession>
    <name>E8N5C1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560015.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16090"/>
    <dbReference type="EnsemblBacteria" id="BAJ63635">
        <property type="protein sequence ID" value="BAJ63635"/>
        <property type="gene ID" value="ANT_16090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16090"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_0_0"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="211" mass="23421" checksum="5F965744DF9B0ADF" modified="2011-04-05" version="1">MILEIIPFELGPLSNNTYLVADSESHTAIIIDPAFGSSAVVKTCLEKQLTIQGIWITHAHFDHIGGVEAVRKHFPQAQIALHPLDQSLWQDGGGSQLFGFHMKPLPAPEVLLNHKQTLPLGTTFFEVLHTPGHTPGHVCFVLHSQKVVFTGDLIFYRGVGRTDLPGGDPKQLYQSIREHIYTLPSDYHLFSGHGPSTTVEEERIENPYISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C5</accession>
    <name>E8N5C5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560019.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16130"/>
    <dbReference type="EnsemblBacteria" id="BAJ63639">
        <property type="protein sequence ID" value="BAJ63639"/>
        <property type="gene ID" value="ANT_16130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16130"/>
    <dbReference type="HOGENOM" id="CLU_2857874_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="64" mass="6573" checksum="0BE2DE279CC595C1" modified="2011-04-05" version="1">MDWKKRTLLIGIVVGAITGAIGAFVLIQAGEKTGNPPKLTAGDGVKVGVGLMAVLRLLTELGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E2</accession>
    <name>E8N5E2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">proC</name>
        <name evidence="5" type="ordered locus">ANT_16300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16300"/>
    <dbReference type="EnsemblBacteria" id="BAJ63656">
        <property type="protein sequence ID" value="BAJ63656"/>
        <property type="gene ID" value="ANT_16300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16300"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_0_1_0"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="162"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="29931" checksum="8B6DACD91ED3A50F" modified="2011-04-05" version="1">MNPKITLIGPGAMGEAIIVGLLSKQITLPEFIFASGPIVERGEELKAKYGIVPLTDNVQAVQQADLVIMAVKPQILKKVMRGLKGHIPAQALVLSIVAGASIQTLSEGLAHTAIVRAMPNTPAQIGEGITVWTASPSVTPEQMELARQVLTALGAEIYEEEESHLDMATALSGTGPAYVFLFMEALIDAGVHMGFARKTAEQLVTQTILGSVLYYKKIGIHPAQLRNQVTSPGGTSAEALYYLEKAGFRTALSRAIWAAYERSLELGKGLNSKPPESKGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E6</accession>
    <name>E8N5E6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560040.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63660">
        <property type="protein sequence ID" value="BAJ63660"/>
        <property type="gene ID" value="ANT_16340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16340"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_0_3_0"/>
    <dbReference type="OMA" id="IWQKERG"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="72" mass="8015" checksum="26D8DAE7BDFF5FF4" modified="2011-04-05" version="1">MSVRYTGTVKWFNATKGYGFIGRDDNAGDDVFVHFSAIQMEGYRTLKEGQKVEFEIEQGPKGLQAAQVVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5M3</accession>
    <name>E8N5M3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-xylose ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_17110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560116.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63737">
        <property type="protein sequence ID" value="BAJ63737"/>
        <property type="gene ID" value="ANT_17110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17110"/>
    <dbReference type="eggNOG" id="COG4214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_0_0"/>
    <dbReference type="OMA" id="VIAVIQY"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="400" mass="43469" checksum="C3CBC806B3F78D12" modified="2011-04-05" version="1">MATISETKTRINIWDEILKRFRLNIQTYTIILAMVAIWILFTILTGGAYLKPQNFSNLFRQMTVTSFLAAGMVLVIVTGNIDLSVGKLAGFVSVVVAYFQANIWNHLLPNQPILAAALSVLVGLGVGTLFGVIQGYIISYLQVPSFIVTLGGMWILNGGILIVTEGKTIPANQPGFSEIAQGYLPLWVGWVLAVGVVILLFYSMLRSRQRKRQYGFELSSLSLDILTTTFFSILVIVYVYIVNLYNGVQTPVLLLAITAVLMSYISSNTRFGRYAYAIGGNREAARLSGINIRKNIFMIFVLMGFLSGVSGIVLASYVGYGTIAAGTGYELDAIASCILGGTSTLGGVGTVFGAMIGSLIMSSLTNGLQMMNVQPAWQYLLKGIVLVLAVYADVYFKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P8</accession>
    <name>E8N5P8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17360"/>
    <dbReference type="EnsemblBacteria" id="BAJ63762">
        <property type="protein sequence ID" value="BAJ63762"/>
        <property type="gene ID" value="ANT_17360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17360"/>
    <dbReference type="HOGENOM" id="CLU_603626_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="453" mass="51894" checksum="FFC52CD48D7AC4ED" modified="2011-04-05" version="1">MTTNEAGCTGDKEHRWNYSRLSSGTTLAPQYAIDMLTITLWRQYRMESTPSPIPLGFHYFTDMEHYRLQDALDFIPLIKSVRGTFLFLPVYSSIAIPEYFLSAWIAESIQPIIHLKIPIENASQNHDLYLLIETYAKRGIKHLIFFDRPNMRRAWPPPVWVLSNLVERFVDQILPLFEFSNKLGVLPVLPPLEPGGDYWDTLFLKSTLQALQRRNAHLQFGYSAYGWTCGHPLNWGAGGPERWPLSLPYHPIQGNEDHRGIRIFEWYSSIAKSFGFDHLPLFILDSGKPDTPLNSFEEWQAIEILNLIRSEQAAGKDIDVQTLGLWMPAEMDSAEFQRGIEKIKEWQDRLEAKNTAQAVHPNSASVIEHYVLIGDSHPAITDWRLRASHAFVLKHKATLGFSLQQASKAKRVTILATEEEIPEENLNDLRHQGILVERISETGTALATILRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S1</accession>
    <name>E8N5S1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="E8N5S1"/>
    <dbReference type="STRING" id="926569.ANT_17590"/>
    <dbReference type="EnsemblBacteria" id="BAJ63785">
        <property type="protein sequence ID" value="BAJ63785"/>
        <property type="gene ID" value="ANT_17590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17590"/>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276188_0_0_0"/>
    <dbReference type="OMA" id="PEWNDAN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1161" mass="132282" checksum="6D3F96C474943D6D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S2</accession>
    <name>E8N5S2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_17600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560164.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17600"/>
    <dbReference type="EnsemblBacteria" id="BAJ63786">
        <property type="protein sequence ID" value="BAJ63786"/>
        <property type="gene ID" value="ANT_17600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17600"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_0"/>
    <dbReference type="OMA" id="QMDVTDR"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="318" mass="35704" checksum="3B79073CD0D31572" modified="2011-04-05" version="1">MSEKTVVFITGVSSGIGLETASLLHQKGFRVIGSSRHPEKLPPFPFPVFSLDITSEESICTCVHRIKSEFGQLDVLICNAGIMGPVAAGEELTPEDLWKVFQTNFFGTVNMIRCVTPLMRTQKGGRIIVLSSIAGKIGAPPFFSAYAASKHALEGYVETIAKELAPFHIHVTLVEPGYFHTAIDQSIQTPPNPISEYQTRRHFTYALQQYAIEHGRHPQQVACAILNTLQKPNPPLRVVVGLDAKFLDTGRRYLPDRLFQFFLSQMFSWKKETQNPVTPIRKFLLNSKIADYSWHILLFGALTFGLVQLMKHIYKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T2</accession>
    <name>E8N5T2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560174.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63796">
        <property type="protein sequence ID" value="BAJ63796"/>
        <property type="gene ID" value="ANT_17700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17700"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_0"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="36"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="400" mass="44459" checksum="FB2C57882737B33B" modified="2011-04-05" version="1">MNTIEKTVVVAGHICLDIFPDMTHLPPGQLMKLLQPGHLILTKGVALCTGGPVSNTGLSLHLLGVPVHLIARIGDDPFGWIVRKLVEQYGVQLAQGLRVEKYSSTSYSIILSAPEVDRIFLHSPGANDEFGMEDIDESWLSQASLFHFGYPPVMKRMVQNRGEELTKIFREVKSFGLTTSLDMALPDPQSEGGKVDWREILGRLLPYVDIFSPSFEELLFMLHRQEWEEFYRTSSSENILRIATPERMSLLGEELVTLGAKIVLLKMGDQGVYLKTSSNWSPMDFGKVQPVPFDEWQNREIRGACFQVNVMGTTGAGDATIAGFLAAFLRGFSPVDAMNAALAVGASNVEAEDALSGIRGWSETLSRIQAGWQRRDLLYPLSGWMALQDGIWEKINQEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V6</accession>
    <name>E8N5V6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_17940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560198.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17940"/>
    <dbReference type="EnsemblBacteria" id="BAJ63820">
        <property type="protein sequence ID" value="BAJ63820"/>
        <property type="gene ID" value="ANT_17940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17940"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_0"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="407" mass="45358" checksum="5B1295518AAE6665" modified="2011-04-05" version="1">MPLVEEIRRQFPILHRQVRKGVPLVYLDSAATSQKPLQVIETMQRFYQLMNANIHRGVHTLAEEATAAYEKARDKVASFIGATSSNEVIYTRNTTEAINLVANSWGRKFLHPGDVIILTEMEHHSNLVPWQMLASEKGLRLEFIPVREDFLLDLDAYRQLLDLRPKLVAFTHMSNVLGTINPAKEIIRLAHEVGALTLVDGAQSVPHFPVNVQDLDADFVAFSAHKMCGPTGIGILYGKQEILDKMPPFLGGGDMIKKVYLRDFVPNSLPHKFEAGTPAIAEAIGLGAAVDFLQEVGMDWIHTHEQEITAYALERLSEVPGLKFFGPEVRYKGGVISFTMQGVHPHDVAQILDREGIAVRAGHHCAMPLHDKFHIPATTRASFYLYSSKEEVDKLVAGLEKVLSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y6</accession>
    <name>E8N5Y6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ordered locus">ANT_18240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560227.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63850">
        <property type="protein sequence ID" value="BAJ63850"/>
        <property type="gene ID" value="ANT_18240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18240"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_2_0"/>
    <dbReference type="OMA" id="TMKMAPQ"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="1 4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="47"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="217" mass="24448" checksum="4CA75F72B1B17871" modified="2011-04-05" version="1">MPNEELHSPGYEIPPEMQNQVTVTTLDRIYNWSRKNSLWPMMFGLACCAIEMIATAASRFDFSRFGMEVMRPSPRQADVMIVSGTVTKKMVPQIVRLYNQMPEPKYVVAMGACASGGGPFKEGYNVVSGIDKFIPVDVYIPGCPPTPQALLNGLIMLQKKVERESLRTVRWYSREPAKPIPVPVLGPDLMDPRRYEEIRSYTLSKLSLQTAEEQTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXE8</accession>
    <name>E8MXE8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560400.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20030"/>
    <dbReference type="EnsemblBacteria" id="BAJ64029">
        <property type="protein sequence ID" value="BAJ64029"/>
        <property type="gene ID" value="ANT_20030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20030"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_0"/>
    <dbReference type="OMA" id="MVIMAKF"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="407"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="496" mass="54724" checksum="7FE0069224557162" modified="2011-04-05" version="1">MNTADYLLQNGKDDAIALISPNHQYTYGEVHTGSARILGALRRCDVQVGDRVAILGSNSLFWVCSYLAILKQGAIAVPLATTHTPEEIQRFIEFTGCRVILSEQRLYPKFLASLNGRIGTLFEDVLHHDESSPVWDEPDPDFDLDQDAALMSTSGTTARPRAVRVTHRNIQANTNSIIAYLELDSSERMMAVLPFYYCFGTSLLHTHLRVGASLVFGGTFTYPETVLDLMEATQCTGFAGVPSIYQTLLRNSSFPKRSWTHLRKLQQAGGKLQNILIEELVHAVPHAKVFVMYGQTEATARLSYLPPELLPQKIGSIGKGIPGVTLSVLNEEGEPVKPNEVGEIYARGENICPGYWNDPEATAEKFINGELKTGDLATIDEDGFIYVVDRKADFIKTYGYRVSSQQVEAALIEIPELVAAAVIGEPDIVRGEAIVAFVVLRDGAVLTEKDILAHCAKRLPHYMVPKEVFFVPALPVNAHGKVVKTELRKQVIQRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF0</accession>
    <name>E8MXF0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">nadE</name>
        <name evidence="8" type="ordered locus">ANT_20050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560402.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64031">
        <property type="protein sequence ID" value="BAJ64031"/>
        <property type="gene ID" value="ANT_20050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20050"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_0_0_0"/>
    <dbReference type="OMA" id="TEYYHAD"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_synthase" evidence="7">
        <location>
            <begin position="164"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="323" mass="36894" checksum="C1C3F27D3872051D" modified="2011-04-05" version="1">MNQVFTRQALELDAQQEVERITRFLREEVLHRLRKQGAVVGISGGIDSSVVLALAVHAFGAQRVVGILLPEKESSPESAELAHLLAEQYGVQTVTEDISSALEGFGCYRRRDEAVRRVFPEFEPSWKSKIVLPGNLLEEDRLNIFSLTVIKPDGTELNRRLPLQEYAQIVAASNFKQRTRMAMLYYHAELRNYAVIGTPNKNEHDLGFFVKYGDGGADVNPIAHLYKTQVYQLARYLEIPKAIQERTPTTDTYPAGSTQEEFFYRIPFHLLDLIWLGYEKQIPTKEIAEAAELTEEQVQRVIADIERKKRATQYLRAHPVHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG9</accession>
    <name>E8MXG9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560420.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64050">
        <property type="protein sequence ID" value="BAJ64050"/>
        <property type="gene ID" value="ANT_20240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20240"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_0_0"/>
    <dbReference type="OMA" id="EYICFIN"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="385" mass="43186" checksum="16EE35266DAEBD6F" modified="2011-04-05" version="1">MPEVTIVLPTYNRADMILDAIRSVQAQTFQDWEIVVVDDGSTDNTEEVVLSLHDSRIHYVYQENKGLAGARNTGIRHAHSELITFLDSDDAFLPQKLEWQVGLMKSRPGLGLVAGDFFFADPHLTPLSEARSWQSYPNLTLKDWILGCPVIVCAVIVQRAWLEKAGGFDETMRYVEDWDLWLRLAYLGCPMDWLPRPVALYRIHGQNMAKQAVLMKQGMLRMFDKFFTLPDLPKDIQSLKEQAYAHAYLNGAARAFAGGDAEEGRNSLEMALKLDPFLLSGEPPQALSSLASFANSPQCHSPSVFLNSLILGLPSQAQKWKPRFIRAVFHAVAAFEKARQGKRSQVPVHALKAVLLDPSWLKNRGLLSIVIKSLLSPFFPLKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI8</accession>
    <name>E8MXI8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">pth</name>
        <name evidence="4" type="ordered locus">ANT_20430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560439.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20430"/>
    <dbReference type="EnsemblBacteria" id="BAJ64069">
        <property type="protein sequence ID" value="BAJ64069"/>
        <property type="gene ID" value="ANT_20430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20430"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_2_2_0"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="208" mass="22881" checksum="6C33A6C26BCFF6C6" modified="2011-04-05" version="1">MLQRLFYHSQAEEPLKPFLIVGLGNPGREYRENRHNAGFMFIDRLAKALLITPGRVQSKAIIATGQYAGKRLILAKPQTYMNLSGQSVKGLAQFYKIPPEQILVAHDDLDLPLGTLRLRPGGGSAGQKGVSSIIQQLGTSQFCRLRIGIGRPPGQMDPAAYVLQDFSEKEKEILDEVMDRAVKAALRFVEAGIQTAMNEFNGSVKEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK5</accession>
    <name>E8MXK5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560456.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20600"/>
    <dbReference type="EnsemblBacteria" id="BAJ64086">
        <property type="protein sequence ID" value="BAJ64086"/>
        <property type="gene ID" value="ANT_20600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20600"/>
    <dbReference type="eggNOG" id="ENOG5033AIT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117974_0_0_0"/>
    <dbReference type="OMA" id="IDAFDKR"/>
    <dbReference type="OrthoDB" id="1981279at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="176" mass="19589" checksum="1BE360613E836428" modified="2011-04-05" version="1">MSDILGRVMEEQDPLRKLLGKIPGFKGYVDRVNRRSADKLLRETIASRFETLVQRISALQRDLVSQGGLRYVDDLEGAVVKLRTFIDRVRTASYGYAGFFDAVKVNSEELALLYQYDLALFESSEAVERAIDNVEAALGTEGLGAAIRALVGESQKCIDAFDKRVQVILQNQGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS3</accession>
    <name>E8MXS3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560524.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64154">
        <property type="protein sequence ID" value="BAJ64154"/>
        <property type="gene ID" value="ANT_21280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21280"/>
    <dbReference type="HOGENOM" id="CLU_715043_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228496" evidence="1">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="348" mass="39449" checksum="FCDD41CD7B8E180C" modified="2011-04-05" version="1">MTLARRFIAFSLLLLVLAACTPATPPAPTNTPRPTPTATLIPTATLIPTATPEPSPTVDPCAYDTSYWSLTPIEPANTGSPKSHLYRLPECAYAGLKKAVAFTLLRVSGGWLFSELYRALGHDYGYPYPYVAGALVNTETQSDVWYSPITQESPFYTRWWNFDPATHESHSQYIFAGCYMNVSVYIQPPGEYRDLPYGCTVAEFIPYDPMGIISLEAPEEERLKAFYSSLMSNFPNVDPKAAGFKIERYYGYLGDGVWMYLGYNEETIQSYPTRERYDMNWQMYRLREPALPVMDLAWVEQEFSLAPKPAPWEVLDVPAEINKENRQTINASNTRFFRTVVLRITPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV9</accession>
    <name>E8MXV9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560560.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64190">
        <property type="protein sequence ID" value="BAJ64190"/>
        <property type="gene ID" value="ANT_21640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21640"/>
    <dbReference type="HOGENOM" id="CLU_1127257_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="28634" checksum="C41679CC23BD8B47" modified="2011-04-05" version="1">MNEIDFSSIAVPEILPDGFRRLEWAYRRPRWRRMVATVLLMAQTGVSTVRELERLTALDRKTIHIVLDSMLDLLDPLIESHVFHAGGRGHLRVVVLTDYAKNLCRALGVEPVESDLEKIMRLHNGEVQTFHAALVLMAAYQARLRGWKAEVMPFDPQETPWFQPDLKVTDPEGWFYYCEVETRSRVKSHKWARMREVNLIVPTPTTRQWMVQRLKDMGIPGRATDLRTLAQQAKAGDLSRFWLEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY09</accession>
    <name>E8MY09_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhB</name>
        <name evidence="8" type="ordered locus">ANT_22140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560609.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22140"/>
    <dbReference type="EnsemblBacteria" id="BAJ64240">
        <property type="protein sequence ID" value="BAJ64240"/>
        <property type="gene ID" value="ANT_22140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22140"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_0_0"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="236" mass="27018" checksum="04D4D5416C6EB5E1" modified="2011-04-05" version="1">MQVKLRVFRFDPERDQKPRYDTFIMDVDPNDRVLDLLEYIKADFDPTLALRRSCAHGVCGSDAMRVNGRNYLACKVLVKNLNADTITVEPLLGLRVIKDLIVDMGPFFENYRSVLPYLINDEPLPEDGKERLQSPEQQLRFEDTTKCILCAACTTSCPSFWADDRYVGPAAIVNAHRFIFDSRDRAAEKRLNILNEQMGVWRCRTAFNCTEACPREIHITQAIAEVKKAIITGKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY51</accession>
    <name>E8MY51_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_22560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560650.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64282">
        <property type="protein sequence ID" value="BAJ64282"/>
        <property type="gene ID" value="ANT_22560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22560"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_11_2_0"/>
    <dbReference type="OMA" id="NPGHINI"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="16"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="318" mass="33688" checksum="CEB7B427F50DC5F6" modified="2011-04-05" version="1">MSLESLQERADRPVLAIGAAGLDMVGVITEPVTERLANPASIRFSFGGVARNVAENLARLGQAVRLATAVGEDPFGSDLLEHTASCGVDVSPSLHVKGYDTGSYLAVYESDGTLKMALEDMQVLQALTPAYIRELEPLFAESSVIFVDANLPPKTLKVVVQQARRLKVPVCADTTSVVLAERLLPYLKHLFLLSTNSKEASVLTNHTPDVTGRASALEVSRFLINQGVEVVIIALAAFGVVYATSETSGHVPAVRTKVVDPTGAGDALTATTLFGLLNNIPLDDSVRLGVTAASLVLRHTGPVYPGISLESLYDQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD9</accession>
    <name>E8MYD9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_00500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PucC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558482.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62084">
        <property type="protein sequence ID" value="BAJ62084"/>
        <property type="gene ID" value="ANT_00500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00500"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030017_1_0_0"/>
    <dbReference type="OMA" id="RVPYIWF"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06176">
        <property type="entry name" value="MFS_BCD_PucC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026036">
        <property type="entry name" value="PucC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004896">
        <property type="entry name" value="PucC-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23538">
        <property type="entry name" value="PTHR23538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03209">
        <property type="entry name" value="PUCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016565">
        <property type="entry name" value="PucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="437" mass="46534" checksum="0F64D539D007CA8D" modified="2011-04-05" version="1">MSMMVKRLQLALIHTAVAVTLVPINSTLNRVMIKELGISAALVALLASLPYVFSPLQVLIGSYSDHHPILGLRRTPYIVLGLLFCAAGVVLAPLAAVEIPVQPVLGLLLTLLVFMAWGMGFNLASVSYLALASEISGEKGRSRTVAIMWVMMVVGIILTAATLGGMLERFDYAALNRAFLTVALGALGLGALGLIGLEKRVSAQPALPLDEERESWQVIFRKVFANPEARLFFGYLLLLLTALLGQDVLLEPYAAEAFGLSVSATTRITSIWGGVMLVAMLATGFLETRLAKKTLARAGGWVGLLGFALIALSSLLAQRGVFYGGVLLLGAGTGIATISNLSLMLDMTTARVGLYIGAWGIASALARLVGNLLSGVVRDAVTFTTQNALAGYLTVFILQALFLLVSLFLLSRVDVRRFRERESLPFAERAAIAGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE2</accession>
    <name>E8MYE2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recN</name>
        <name evidence="7" type="ordered locus">ANT_00530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558485.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62087">
        <property type="protein sequence ID" value="BAJ62087"/>
        <property type="gene ID" value="ANT_00530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00530"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_0"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="21"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="155"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="334"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="580" mass="64330" checksum="AFB12F6F84E81B78" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYG0</accession>
    <name>E8MYG0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558503.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00710"/>
    <dbReference type="EnsemblBacteria" id="BAJ62105">
        <property type="protein sequence ID" value="BAJ62105"/>
        <property type="gene ID" value="ANT_00710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00710"/>
    <dbReference type="HOGENOM" id="CLU_1068095_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036700">
        <property type="entry name" value="BOBF_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101756">
        <property type="entry name" value="SSF101756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="27693" checksum="7372EEB1E7BAF9A6" modified="2011-04-05" version="1">MSRKILVLTLASAVVSAILLFVGTTVMGFFSPVSADSLPALVLGKRVTNDTALQAQSGADDTPTPTPFQPAPTETALPTATFSPQETPAQQPTPIPAVSLTIAQLLANPGAYLNQMVSLSGMVNVISRELFLLNDGTGQIVVDVEEDGVAGALSNGMTVTVVGRFDDYSKGGSYKIEACTVTDSSGKVWSNQCHNHDEDDDTSLTSTPHDDKDDDHKSTLQPTRTDDHDDDHDRSGKSTPKPTQSDDDHEDDGDHRNKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYG8</accession>
    <name>E8MYG8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ordered locus">ANT_00790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00790"/>
    <dbReference type="EnsemblBacteria" id="BAJ62113">
        <property type="protein sequence ID" value="BAJ62113"/>
        <property type="gene ID" value="ANT_00790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00790"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_6_1_0"/>
    <dbReference type="OMA" id="PRMKEIK"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="204" mass="22156" checksum="0861A9C47025AD3E" modified="2011-04-05" version="1">MDLWNILSFMALGFTLGSIPFAYILARVFTGRDVRAIGDGNPGAANAWKAGGWRIGLLAVFFDLCKGFLPLFLAQRAGLSEWALVPVALSPILGHALQPFLQFRGGKALAVSGGVWLAWIGPRVFPVYASLTLPVLALQEEHAWAAFSGTLALLAYALWLGTSPALMVFAALNMVLIGWTHRRELAHAPRPRAWVGHLLSRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN3</accession>
    <name>E8MYN3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">ddl</name>
        <name evidence="11" type="ordered locus">ANT_23430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560735.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23430"/>
    <dbReference type="EnsemblBacteria" id="BAJ64369">
        <property type="protein sequence ID" value="BAJ64369"/>
        <property type="gene ID" value="ANT_23430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23430"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_0_0_0"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="142"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="369" mass="40801" checksum="1396471B8514AAFD" modified="2011-04-05" version="1">MERKLRVGVIFGGRSGEHEVSLMSSRSVLNVLSPEKYEVTQIGITLEGMWVTGENVWKALKSGQVKGLSQAVLLPYPGETILYALRNGTLEPVTTLDVIFPVLHGTFGEDGTLQGLLEMADCAYVGAGVLGSAVGMDKGLFKDVMRAHGLPVADSVLVTRKQLEQNLSEVIEQVERLGEYPFFTKPANLGSSVGITKCHSRSELYEGLLEAARYDRRILIERGVPDAREIEVSVLGNDEPIASVPGEIVPGDEFYSYEAKYLMETSKLLIPAPLSEALSERIRQLAIQAYRAIDCAGMARVDFLVNRNTGECFINEINTIPGFTAISMYPKLWEASGISYTALIDRLIELALERKAERDRTQRHYRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP2</accession>
    <name>E8MYP2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560744.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23520"/>
    <dbReference type="EnsemblBacteria" id="BAJ64378">
        <property type="protein sequence ID" value="BAJ64378"/>
        <property type="gene ID" value="ANT_23520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23520"/>
    <dbReference type="eggNOG" id="ENOG5032YH0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056208_0_0_0"/>
    <dbReference type="OMA" id="VIGNWRE"/>
    <dbReference type="OrthoDB" id="2013925at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019206">
        <property type="entry name" value="DUF2085_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09858">
        <property type="entry name" value="DUF2085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="263" mass="28726" checksum="93395300259E1C03" modified="2011-04-05" version="1">MQFSLRWKIAIITATAALLLTWLVKTPPGLLGKMDAVGYAVCHRAPARSFWLEDRPTPVCARCSGTFLGSGLSLVYILRKGKRALFPPRWMMMVFAGFALFFALDGANSFLSALPGLSSLYSPNNPLRLVSGTLLGLAVGSVLAPTFHQTVWKDSLPQPALTSIREGGTLLGLALAMDAAILSEIPLLLYPLAVLSGISVLGLLSIAYALLWILLAQSENRFSEWKELWIFLWLGFLTALLQISLMDAGRFWLTGTWDGFPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS6</accession>
    <name>E8MYS6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64412">
        <property type="protein sequence ID" value="BAJ64412"/>
        <property type="gene ID" value="ANT_23860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23860"/>
    <dbReference type="HOGENOM" id="CLU_2912330_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="61" mass="6440" checksum="3BF3646C22BD5D17" modified="2011-04-05" version="1">MRPGDLPVPSAYAVVKVLPLAGNHPGGLAPPYALCGVEFSLGQGWVALPVLLARLKWDFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYV4</accession>
    <name>E8MYV4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560795.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24140"/>
    <dbReference type="EnsemblBacteria" id="BAJ64440">
        <property type="protein sequence ID" value="BAJ64440"/>
        <property type="gene ID" value="ANT_24140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24140"/>
    <dbReference type="HOGENOM" id="CLU_2821696_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="66" mass="7937" checksum="89E292A12B851224" modified="2011-04-05" version="1">MGEEELTHLLERLRERRLFDEVFVLILEREPQGDWKLLDYGMREISDVAAWLAVQKQKYTSEKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW0</accession>
    <name>E8MYW0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64446">
        <property type="protein sequence ID" value="BAJ64446"/>
        <property type="gene ID" value="ANT_24200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24200"/>
    <dbReference type="HOGENOM" id="CLU_1131755_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228539" evidence="1">
        <location>
            <begin position="24"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="241" mass="27511" checksum="DC8ADA7048E177C0" modified="2011-04-05" version="1">MKMRKTIVFMLALVLLAGCSLRATPTPTAAPRPTPTPTEEVRYYPTVSPDIRTSLVNQLPSDTFPSRYYEPPEGNYFVAMTVSTGETGQMTAGKWTLDVLWVYERNASVVFYPLVLGVWDGNTYTPYLFPAYDEFPTDRESYFRYLDDNRILERGRLIFPRVQGDFVSRTGIDWQKCGESTFCQVGRFMQETYNLDRVVELGIVGVNYPIPEGWALAWYWIPSTEKNTMPGFDKVDLPGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ15</accession>
    <name>E8MZ15_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558556.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62158">
        <property type="protein sequence ID" value="BAJ62158"/>
        <property type="gene ID" value="ANT_01240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01240"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_1_0"/>
    <dbReference type="OMA" id="YGAKIMK"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017706">
        <property type="entry name" value="Peptidase_M20/DapE_YgeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03526">
        <property type="entry name" value="selenium_YgeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="183"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="404" mass="44731" checksum="23BF8B7D13D13E0D" modified="2011-04-05" version="1">MVESHVVQLIQERVRTAEEDIIRFLREICAIPSMESQIGPVGERIGAEMRKLGFDEVRFDKMGNILGRIGNGPKVLVYDSHIDTVGVGDPAEWPYDPFEGKIENGCLYARGAVDEKGSTPGMVYGLAIARDLGLLDGWTVYYFGNMEEWCDGIAPNSFVEVDPGVRPDFVVIGEPTMMKVYRGHKGRLEFKVTARGKSAHAASNHLGDNAIYKLLPVIAGIRDLEPALGDHPFLGHGKITVTDMKVRTASINAVPDEAVIFIDRRMTFGETKEQVIEQVRALIPEKDRESVTIEELFYDEPSYTGFVFPVDKYFPAWALDEEHPLVQAGQKTRTLIGLPEAPSGKWDFSTNGIYWAGKAGIPSIGFGPGDERLAHAMAEHVPLAEVVKAAEFYALLPRIIQETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ27</accession>
    <name>E8MZ27_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recR</name>
        <name evidence="9" type="ordered locus">ANT_01360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558568.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62170">
        <property type="protein sequence ID" value="BAJ62170"/>
        <property type="gene ID" value="ANT_01360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01360"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_0"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="83"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="201" mass="22017" checksum="BE47D1F0ED9EAB6D" modified="2011-04-05" version="1">MAGLPAPLEALITAFERLPGIGPKTASRLAFFILRQPDEVAQQLAEALLAVKSQTANCPVCFNIMLAGQERCQICADPRRDESQLCVVEDPLDVLVIERTGGFLGRYHVLQGVLNPIEGIGPEQLRIRPLIERVQEGRVREVIIATNPSMEGDATALYLRQQLAPLGVRITRLARGLPMGGDLEYADQNTLLRALAGRQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ41</accession>
    <name>E8MZ41_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_01500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558582.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62184">
        <property type="protein sequence ID" value="BAJ62184"/>
        <property type="gene ID" value="ANT_01500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01500"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="VYQEIYY"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="336"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="582" mass="64162" checksum="0598B0C679074DF9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ60</accession>
    <name>E8MZ60_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tmk</name>
        <name evidence="5" type="ordered locus">ANT_01690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558601.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01690"/>
    <dbReference type="EnsemblBacteria" id="BAJ62203">
        <property type="protein sequence ID" value="BAJ62203"/>
        <property type="gene ID" value="ANT_01690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01690"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_0"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="205" mass="23348" checksum="B2159C19C4999AEA" modified="2011-04-05" version="1">MFITFEGPEGSGKTTQIRLFAEFLRARGYDVLTTREPGGTEISDQIRAVLVNLRNTAMHPRTEILLFQAARAQLVEQVIRPALSRGTLVLSDRYADSTLAYQGYGHGYPLEELRRLIDFATGGLIPDLTFLLDVNPAQGLERKQREGEWNRLDAYDLGFHQRVRAGYLEMARAEPHRWVVVDATQSIEVIQSDIRRCFEQRLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ64</accession>
    <name>E8MZ64_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558605.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01730"/>
    <dbReference type="EnsemblBacteria" id="BAJ62207">
        <property type="protein sequence ID" value="BAJ62207"/>
        <property type="gene ID" value="ANT_01730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01730"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_3_0"/>
    <dbReference type="OMA" id="HTMAKVK"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="211"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="413" mass="46115" checksum="2BC4937E47E89233" modified="2011-04-05" version="1">MNIAMLSYHTCPLATLGGKDTGGMNVYVREVTRFLGMRGVHVDVFTRSQDEHVPHVLHDLGFGNRVVHLPAGAETWLPKRQLVDFIPQFAEGVLRFAREKGIHYDLIHANYWMSGIAAETLKAEWNVPVVTMFHTLGLMKNRIARSPEEMEGEYRINGERRVLQISDRIIAATLAEKAQLQFLYQADEGKIRIVPPGVDTARFYPIPREEACEAIGIPPEDRMLLFVGRIEPLKGLDTLMRAIAILRECGVQCHVPHYLAVVGGDPSASGEKLSDEMARLQALRRELHLEDLVLFLGKRAQDTLPYYYSAAEVLIMPSHYESFGMVALEAMACGTPVVASQVGGLAFLVQDGLTGYVVPDGDPQALSERLRLLLMDGELRQRMGLQAAAYARQYAWENIVERLLGVYSEVLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA5</accession>
    <name>E8MZA5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02140"/>
    <dbReference type="EnsemblBacteria" id="BAJ62248">
        <property type="protein sequence ID" value="BAJ62248"/>
        <property type="gene ID" value="ANT_02140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02140"/>
    <dbReference type="HOGENOM" id="CLU_726924_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="43395" checksum="BF2AF681B4CBB8D3" modified="2011-04-05" version="1">MNCFSKFVHFLILLLGAFPLSSCNILGQKMEIQSFPVKEFPFALELQPVPLEDAMPYFNDPLIQEQIEGIESITQDGWQSIHVVSVAGNSPEQLQVGPSIVIKPGKPLMGFILFFNTHQYDRNLGMLTVLDGEQVIIKTSQGIEKRPSLFLERNKWQAFRFFMDPLPEGLHTLIMTAIVEPGLNFYVSERKVKLTTYETDVLGHRDSPIEFKKLLWVTSDSPQSVEDWPPSVRTPAPDQVVSVLSARLVGYKPRFGESQWLYYYDEVRPGDLLTYYLTLGGQTSTEIPGEQRLPMDILVFWDDKLTQRTRLQIPVQAVVNKTYLSYPIEVPKDLPPGKHNLTAIGYPYPGYLHSWLGDRSWNPPVYFNSYVLAHFPILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZB8</accession>
    <name>E8MZB8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nusA</name>
        <name evidence="10" type="ordered locus">ANT_02270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558659.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02270"/>
    <dbReference type="EnsemblBacteria" id="BAJ62261">
        <property type="protein sequence ID" value="BAJ62261"/>
        <property type="gene ID" value="ANT_02270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02270"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_1_0"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="633" mass="70276" checksum="F1294EEC6074EF8A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG9</accession>
    <name>E8MZG9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5 8" type="primary">xylB</name>
        <name evidence="8" type="ordered locus">ANT_24910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560872.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24910"/>
    <dbReference type="EnsemblBacteria" id="BAJ64517">
        <property type="protein sequence ID" value="BAJ64517"/>
        <property type="gene ID" value="ANT_24910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24910"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_0"/>
    <dbReference type="OMA" id="WHVMGVT"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="257"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="498" mass="53757" checksum="DE7338FF97A7EA90" modified="2011-04-05" version="1">MAYFLGIDVSTTGVKALLMDEQGQVVGTANTEQPLYTPYPLWSEQNPQDWWNGAVNSIRTVLSQSGVDGSQVLGVGLTGQMHGLTLLDEEGNVLRPAILWNDQRTAQQCDEIRARLGKSRLIQITGNDALTGFTAPKILWVREHEPEVYARVRHILLPKDYVRYRLTGEFAVDCADGAGTILFDLRQRTWSDEVLKAMDIPLEWLPKTYEGPEITGRITPEAAQATGLKQGTPVMAGGGDQAAQAVGVGAVQPGIVALTLGTSGVVFATTGEPFIEPEGRLHAFCHSVPGRWHLMGVMLSAAGSLRWYRDALAPGVSYDDLLAPAADVPMGSEGLLFLPYLTGERTPHPDPLARGAFVGLTVRHTRAHMTRAVLEGVAFGLRDGFELMKSAGLTHIEQVRVSGGGARSPLWRQILADVFDAELVTVNTTEGAAYGAALLAGVGAGIWKTVDEACSAAIRITGSTAPRPEGVSFYQKAYQGYRQLYPALRDLSHALSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH1</accession>
    <name>E8MZH1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_24930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560874.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64519">
        <property type="protein sequence ID" value="BAJ64519"/>
        <property type="gene ID" value="ANT_24930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24930"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="YNRYDAY"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="360" mass="40440" checksum="25B2B4B3A85EA79A" modified="2011-04-05" version="1">MAMNPQKRATLKEVARLAGVSYQTVSKVLNGQVQLPEVTEARIWEAVRALNYTPNHTARSLRSRRSHTIAYCWAPTATGQANPILDELLQSMVQAAEQQGYYLLCFPNLPDPNRQREAYRELIDSGRVDGFILSSVEYEDPRILYLMERRFPFVAFGRSNPEYQFPSIDIDGGMGMLKVVRHLVERGHRRIAALTWPPESRVGANRISGFLQGLIEADIPPVPEWMERGEGVPSFGYQATLRLLKLPEAMRPTAIVAFNDAMALGAVRAAQQLGYRVGSDIAVTGFDDTPIARYTLPPLTSVRQPIWEVGERLVNRLIALLDHPEISSPYCELIEPELIIRASSTGEETPLDQDHPYLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI5</accession>
    <name>E8MZI5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hrcA</name>
        <name evidence="6" type="ordered locus">ANT_25070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560888.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25070"/>
    <dbReference type="EnsemblBacteria" id="BAJ64533">
        <property type="protein sequence ID" value="BAJ64533"/>
        <property type="gene ID" value="ANT_25070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25070"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_1_0_0"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="OrthoDB" id="1510750at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="2 4" id="KW-0346">Stress response</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="5">
        <location>
            <begin position="107"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="352" mass="39344" checksum="7E337D39432A6B83" modified="2011-04-05" version="1">MNREPTERQKFLLALVVHEYVRTALPVGSRTLVEQYKLDMSSATVRNELAALTEMGYLRQPHTSAGRVPTEEGYRFFVGRLMQETALPDSTRHTITHQFYQMGTDVEQWMRLAASVLAHQSRAASLVTAPHPERARLKHLELISTRGRQVLMVLVIVGGEIRQRILTLSEPIPQEKLSEAAERITRQLQDCDADGIRAVRSRFDGLEYDVLGYVVEDLDKTERTIAGEIFTDGLTNVLAEPEFSNSEEARRALRLLEERSLLQELLARTVFATNSVGGVQVLIGGEGTWEDLRQSSLLLTRYGVPGQATGTLGVLGPMRMAYGRTISTLRFLAGLLSDLVAETLVEDENHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI7</accession>
    <name>E8MZI7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560890.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25090"/>
    <dbReference type="EnsemblBacteria" id="BAJ64535">
        <property type="protein sequence ID" value="BAJ64535"/>
        <property type="gene ID" value="ANT_25090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25090"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703295_0_0_0"/>
    <dbReference type="OMA" id="KYAWAME"/>
    <dbReference type="OrthoDB" id="1567543at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="392" mass="46777" checksum="1E515C14A45E8D7E" modified="2011-04-05" version="1">MDLEQLQKRIEWLEGERRKDKAIIDTLEQRLASLEAGLPDVQSKVKELEGEVSRLSTLSTRFDQIDAAILQVRSEFTRTIENIERLRAEYNRDMEKVRQDDLDTFNRAIGELRKNIEILPELRKNLQARVEEDFRLSRLIEGLEVKLVESRRSEEEYRRAQKLIEEAQKQETKRMTDLQGEVSAIRKRLEELRGKVELLSDGSRKLETRLTEIQTAESERRQAQTAFIDKVNMMQVERERIWKDWQSRFEAIERLAQGLDTQAQALDSTHRAVKRAQEAFEEITQKFERRINEITEMQRLTEERFRQEWMTFRADDQKRWTNYTLVQEEQLRENARQNERIQDQLTALQDALQDINDTLHNITQETQKRLQTLLALAHQWMEEYDRTFGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI8</accession>
    <name>E8MZI8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">SelB translation factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">selB</name>
        <name evidence="7" type="ordered locus">ANT_25100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560891.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25100"/>
    <dbReference type="EnsemblBacteria" id="BAJ64536">
        <property type="protein sequence ID" value="BAJ64536"/>
        <property type="gene ID" value="ANT_25100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25100"/>
    <dbReference type="eggNOG" id="COG3276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023030_3_0_0"/>
    <dbReference type="OMA" id="YAIDRVF"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015190">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09106">
        <property type="entry name" value="SelB-wing_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="630" mass="70175" checksum="2AFF9061161BA66F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK6</accession>
    <name>E8MZK6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative fatty acid desaturase</fullName>
            <ecNumber evidence="3">1.14.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25280"/>
    <dbReference type="EnsemblBacteria" id="BAJ64554">
        <property type="protein sequence ID" value="BAJ64554"/>
        <property type="gene ID" value="ANT_25280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25280"/>
    <dbReference type="eggNOG" id="COG3239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043118_0_0_0"/>
    <dbReference type="OMA" id="PYDCWRR"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="374" mass="42778" checksum="0A9A5FBAA11E4D80" modified="2011-04-05" version="1">MTPVSSVFLPLQVCWEAGETCMETLTLPTLKNHPAIETEPPVKKLPTMKELNPLLLPFQKPEWKPAIWQLINTLVPFFALLGLMGASLQMSYWLTLLLALPTAGFLVRIFILFHDCGHNSFTPSRKANKIIGFILGVITLTPSEQWWKSHAIHHATSGNLDKRGVGDVTTLTVEEYRAKPWIERMGYALFRFPFIMFGLGPIWMFIIAHRFALPRFSKKETLSVVWTNIALIFYLGGLSLLFGGVWNMVKVLLPVFWLAGMFGIWLFYVQHQFEGVYWAPDTEWDYVASALKGASYYRLPKVLQFFSGNIGFHHIHHLSPRIPNYQLEACYKSNPIFQIEVTEIGFLEALKTVRLKLIDTARNNQMVTFQDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK7</accession>
    <name>E8MZK7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="10">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">secA</name>
        <name evidence="15" type="ordered locus">ANT_25290</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560910.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25290"/>
    <dbReference type="EnsemblBacteria" id="BAJ64555">
        <property type="protein sequence ID" value="BAJ64555"/>
        <property type="gene ID" value="ANT_25290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25290"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_0"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="14">
        <location>
            <begin position="3"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="104"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1330"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ64555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1362" mass="156298" checksum="738D389346FF5BA8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZL5</accession>
    <name>E8MZL5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560918.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25370"/>
    <dbReference type="EnsemblBacteria" id="BAJ64563">
        <property type="protein sequence ID" value="BAJ64563"/>
        <property type="gene ID" value="ANT_25370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25370"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036799_0_0_0"/>
    <dbReference type="OrthoDB" id="1567367at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225348" evidence="2">
        <location>
            <begin position="32"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="470" mass="49283" checksum="7ED0E576FBF63501" modified="2011-04-05" version="1">MKPIRVSSVAWFAMLILGVCLLGLRVQPVQAAVVDEDGNVGAKEVIQDDLIIGGQNVIIDGTVNGAVLASAERIVVNGTINGDLFMFGQTVLLAENGKVSGNVFIGAQSGEVRGKVGGSVFTGATSLLVGSQARIERNLYFGGYSLETLNGSVIKIDALVGAYQIIHAGEIQQNLKGGVAGAELKGKVGKDVKLDVAAPGETGSNFWMFWYQPGMPKAIEPGLRVAPEAVIGGDLTYTSPAEQASAIQARPKGQVIYQTPTPAEKAPQKSPLQRWEEHPVLKTLLGLVRNLIVLLILGGLALWLIPGIFHKTADMANAKPLPSAGVGILTLLGGYAGAILAGLLLLAIGVILSLITLGGLSNAIFGIGFSALALLVAIFTLLVGYGSKLVVSFWVGKQLLEKTAPQTRNLHIWALVLGVALYAIVRAIPFIGWLIGLIATLIGLGAMWYTYQSRKAPTPEVVPAPLPEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZL9</accession>
    <name>E8MZL9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">ANT_25410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560922.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25410"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="EnsemblBacteria" id="BAJ64567">
        <property type="protein sequence ID" value="BAJ64567"/>
        <property type="gene ID" value="ANT_25410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25410"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_0"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="304"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="540" mass="60286" checksum="C4FEA12B9770C03E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN5</accession>
    <name>E8MZN5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcrA</name>
        <name evidence="9" type="ordered locus">ANT_25570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560938.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64583">
        <property type="protein sequence ID" value="BAJ64583"/>
        <property type="gene ID" value="ANT_25570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25570"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_0"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="283"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="737" mass="84065" checksum="D6535A7CCD604EE3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV1</accession>
    <name>E8MZV1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_02520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558683.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62286">
        <property type="protein sequence ID" value="BAJ62286"/>
        <property type="gene ID" value="ANT_02520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02520"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_0"/>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="340" mass="35527" checksum="7F56B12FBC5DC726" modified="2011-04-05" version="1">MKHTARPLLFSIPPLFLSLLLSVAVGSVFIPPATLFHLLGVRLAGGTIPAEWQSFAVIVFDLRLPRTALMLLTGAALGGSGAAFQGLFRNPLADPYLIGVASGAGLGAVLTLTGGLPRSLAGYFTVPVAAFIGALITVAVVYSLARVGRTVPTTHLILAGVAVSSFTSALTSFLMLTSTGELRRALVWLLGGASIGGWRPVLGALPYIVVGLGVLCLSGHALNVFQFGEEQARQLGLPVERVRLIIVAAASLATAAAVAYAGIIGFVGLIVPHLMRFFFGADYRHVIPLSVLGGATLLLLADVLARVVMAPQELPVGMITALSGAPFFLWVLQRTRQQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY2</accession>
    <name>E8MZY2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558714.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02830"/>
    <dbReference type="EnsemblBacteria" id="BAJ62317">
        <property type="protein sequence ID" value="BAJ62317"/>
        <property type="gene ID" value="ANT_02830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02830"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1871098_0_0_0"/>
    <dbReference type="OrthoDB" id="10143at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="SSF51120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="14015" checksum="19875095EB5B9E1C" modified="2011-04-05" version="1">MRRLRVLLGVMFVFILLGAVSAVAGANVVPVTRAGMITRTNTPNDFRPPACTANVTSIISGSGTLNGTPGNDLMLGSAVGDTLYGGAGNDCLMGGGGFDWLFGEDGNDYLNGGPGFDLCFGGLGLNTYDVSCEIQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ1</accession>
    <name>E8MZZ1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02920"/>
    <dbReference type="EnsemblBacteria" id="BAJ62326">
        <property type="protein sequence ID" value="BAJ62326"/>
        <property type="gene ID" value="ANT_02920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02920"/>
    <dbReference type="HOGENOM" id="CLU_2021910_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012550">
        <property type="entry name" value="DUF1706"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08020">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="122" mass="14086" checksum="B1C9E87F0AFA2F20" modified="2011-04-05" version="1">MCWCTSTTGREGETITLLYTLKRGAPVTSILLDPNLDVDACNARWVAMAKERPWERVWSDFQGVHTQLLRRVAEFSDEQLFQAGLHPKLGKTPLWRIIAVCAFEHEREHAEGLRVWQKQIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ5</accession>
    <name>E8MZZ5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase molybdoprotein family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558727.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02960"/>
    <dbReference type="EnsemblBacteria" id="BAJ62330">
        <property type="protein sequence ID" value="BAJ62330"/>
        <property type="gene ID" value="ANT_02960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02960"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_1_0"/>
    <dbReference type="OMA" id="SWMRAPG"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="775" mass="84386" checksum="0E215EFBA57B30CD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N016</accession>
    <name>E8N016_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">gatA</name>
        <name evidence="9" type="ordered locus">ANT_03170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558748.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62351">
        <property type="protein sequence ID" value="BAJ62351"/>
        <property type="gene ID" value="ANT_03170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03170"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="496" mass="53483" checksum="8C6387F7404DAAD4" modified="2011-04-05" version="1">MSRIPDLSVSELLAGMRRGDFSAVEVTRAFLEVIERLEPSLHTLITFTPELALRMAEDADRRYRAWRRADSPAEEALPPLLGIPLMVKDVLCLKGVPCTCGSRILQDFIPPYTATAVQRLLDAGVVVLGKTNTDEFAMGSSTENSAFGATRNPWNPAHVPGGSSGGSASAVAARMTPAALGSDTGGSIRQPAAYCGVTGIKPTYGRVSRYGLVAYGSSLDTVGVFARSAAETALFFSLMAGHDPLDSTSAREAVSPITLPDEPALKGLRIGVPQEYFIPGMSAEVEQAVRAAIAQLEHLGATVQMVRLPHTEYALPVYYLIAPAEASANLARYDGVRFGLRAPAERLWEMFDRTRGSGFGAEVKRRIMLGTYALSAGYYDAYYAQAQKVRTLIRQDFLDAFQQVDVIACPVAPTPAFRLGEHTDDPLAMYLEDIFTLPANLAGVPGLAFPAGFSAAGLPIGIQLMSAPFREEILFQTAHAYQQVTDWHLRRPPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N044</accession>
    <name>E8N044_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_03450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558776.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62379">
        <property type="protein sequence ID" value="BAJ62379"/>
        <property type="gene ID" value="ANT_03450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03450"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278344_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011620">
        <property type="entry name" value="Sig_transdc_His_kinase_LytS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07694">
        <property type="entry name" value="5TM-5TMR_LYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="8">
        <location>
            <begin position="948"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1136" mass="128928" checksum="35B7FD95D30F2599" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B4</accession>
    <name>E8N0B4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561017.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26370"/>
    <dbReference type="EnsemblBacteria" id="BAJ64663">
        <property type="protein sequence ID" value="BAJ64663"/>
        <property type="gene ID" value="ANT_26370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26370"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OMA" id="NTYLMYG"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="302" mass="33852" checksum="81D451D3A6620CD5" modified="2011-04-05" version="1">MRRRWFQFSSSYRNRGINPQGFHPSQLKFYLILLPLSAFMLLPMVFIFSHAFKPPDELFAYPPRFFVVNPTLKNFIDLFSRMSASSIPVSRYLFNSILVTVVTVAASVVVSSTAAYALSKKRFKLKQTLFAINTVALMFVPIAVTIPRFLIIERLHLMDTFWVHILPMLAMPVGLFLIKQFIDGIPDEVVEAAQIDGASDVWIYWQIILPMIRPAIATIAILSFQAAWNNADTSALYINNESLKTFAFYLTTLTSTTTGANVVAGQGIAAAASLIMFLPNLIIFIFMQSQVMSTMSHSGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L4</accession>
    <name>E8N0L4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64763">
        <property type="protein sequence ID" value="BAJ64763"/>
        <property type="gene ID" value="ANT_27370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27370"/>
    <dbReference type="HOGENOM" id="CLU_553945_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase_6" evidence="2">
        <location>
            <begin position="341"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="492" mass="56286" checksum="EE31A555F7C49F0A" modified="2011-04-05" version="1">MHPTGFASLRFAAQVKRRPLGCSFLLTLMSKRKETITQQAVTPYHIFHRVPPIKSSEIERRAKMSTSKSSFWKRIYVAAVVITTVVIGTIGAVPLSTASASSVNEQTISQDVKILLSDYSMYLSNGQIFRPAYYTVEMEKLIQERRAYYDEFFNVGLHINLLQIKSEFLVDEKTTEKRDGDTIHVHITEKVTLLGTPKISSSKEYPLIQAAYWAISETDDTRVKNALENFIENMSEGVNESIRDGVEIAFIVHHDIVIKAGDKGQFQFISDSFTDKSNDNIEGNDNVAWSDNEFTRSKPDLTRMPDYIIYNTTIEEIGKWLLDDYSRSYREDREYLATETYNRQNARSYINTYTSNPNGKYCPNTSVPQDKTKYNPYYIAQEPCVDCVNYVSQAIKAGGYQTDNTWKPYTYAWINTYGLRDYLLYTKEVGVWYSNLTSLQVGDIAFTGNYSHVVMVGAVSPHRYSGHTSDRKIYSWNSSLTRYMHILEIPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P4</accession>
    <name>E8N0P4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558835.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04050"/>
    <dbReference type="EnsemblBacteria" id="BAJ62439">
        <property type="protein sequence ID" value="BAJ62439"/>
        <property type="gene ID" value="ANT_04050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04050"/>
    <dbReference type="eggNOG" id="COG2222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_2_0_0"/>
    <dbReference type="OMA" id="WTVGLAH"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="31"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="196"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="349" mass="37642" checksum="895DE06C309B55A2" modified="2011-04-05" version="1">MENGTFTLQEILSQPQAWASALDVLKASQADIRRFQPGEYAQILFTGCGSTYYLALSAAALTQELTGAPARAFPASELWLNPDIVYTGGKTLLVAVSRSGETSETLHACRAFLDQKRGDLITLSCYPQTPLAGMGTLNLVLPSGQEQSVAQTRAFSTLYLGTMALACEWSGRADLLDALTRLPEAGAQVLENSAGLAGELGQDASLDRFYWLGSGTRYGLACELSLKMKEMSLSHSEPFHFLEFRHGPKSMITDSAVVIGLRSARNGQAEGAVLDDMLALGGRVVDLAFADAPLFPEKATYRLTLPAPLSEAIRNILYLPVGQRIAFERALSKGLNPDRPTHLDTVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S8</accession>
    <name>E8N0S8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_04390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558869.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62473">
        <property type="protein sequence ID" value="BAJ62473"/>
        <property type="gene ID" value="ANT_04390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04390"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_656637_0_0_0"/>
    <dbReference type="OMA" id="PYTGPRG"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="418" mass="45009" checksum="8417899095617A20" modified="2011-04-05" version="1">MNAKKTLLNETLIWFLIAMILANIAGSMYMDLLPLYLQELNASVAQVGLFFTLSAIIPLALQILGGWISDSLGRLRSIALGSLAGVLSYVGLVLAPSWEWLLLAQGLGAVTSALVAPSYGAFIAESSSEENRARVFGVVETLYSVVGIVGPPLGAWLVELRGFKPMLFVAGILYLSATIIRVRMARNARRQNPAPASALTLDSLRGNLRSLLILLVSGGLLTWLFLTDGVRDIFFRMSFTFFPVYLKSVGGLTIQQIGWLSASLSTAIMATNLLGGWLADRKGEHVAISLGFLLDGISMLIFLRASTFPLFLLSWVLAGVGIGMMSPAYSSLMSKALPERLRGTGFGLLHSSLGVFSLPAPSIGAYLYEKFSPRAPFMLTTVISFLTILPAWFKFRPQKATPAPLAVEGQTAPVSEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W8</accession>
    <name>E8N0W8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_04790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558909.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04790"/>
    <dbReference type="EnsemblBacteria" id="BAJ62513">
        <property type="protein sequence ID" value="BAJ62513"/>
        <property type="gene ID" value="ANT_04790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04790"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302801_0_0_0"/>
    <dbReference type="OrthoDB" id="2040132at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228038" evidence="2">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="211" mass="22752" checksum="A6D4BA81C15C4694" modified="2011-04-05" version="1">MNKSLRFFWMMVLLVVLILSTACTLRASTPPAPTQEQGVLFPTPTSVANAVQTQTAQAQPQIATATPQVEAPTPVPQQAEQPQPTAQAPQPQPIPTLERPSTYTLQKGEWPICIARRYDLDLNALFSLNGLNMNSRPAVGTVLKIPSSGNWNEAAYGPRALRKHTDYKVAAGDTVYTIACYFGDVSPEAILAANGLNSPNDVKPGMTLKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y3</accession>
    <name>E8N0Y3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_04940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04940"/>
    <dbReference type="EnsemblBacteria" id="BAJ62528">
        <property type="protein sequence ID" value="BAJ62528"/>
        <property type="gene ID" value="ANT_04940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04940"/>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_0_1_0"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="297" mass="32170" checksum="E6B84072FAC7EF11" modified="2011-04-05" version="1">MKPFPFLFGPMRVPFLLLTPACVAVGVATAYRQTGHLSLLDILIVLIGALAAHISVNVFNEYYDFKSGLDSRTQRTPFSGGSGSLQAHPEMARATLILAWASFAVTALVGLYFVWKQGWGLLPLGILGLVILVTYTLWFVYQPVLCLIVPGLGFGILMVMGTHYALTGTYTWTAFIASLVPTFLVSNLLLLNQFPDVEADQSVGRRHYPIVLGRRASSVVYGLFLLGAYLAVGVGVALRLLPWTSLLALLTLVLSWKAFRGAFENAENIPALIPSMGMNVIINLATPVLLALGLFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N159</accession>
    <name>E8N159_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561150.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64802">
        <property type="protein sequence ID" value="BAJ64802"/>
        <property type="gene ID" value="ANT_27760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27760"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_0"/>
    <dbReference type="OMA" id="ENDHQIN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="225" mass="25625" checksum="5F34ECFFF9F2ACB5" modified="2011-04-05" version="1">MPRATLDRQLHLIQDEVLTLGSMVEQALVKSVDALKRRDVKAAAEIIRGDQAINEKRYAIENGIIAVVATQQPMAHDLRLLAAVLEVIIELERMGDYAKGIARVCQRLEGVDIPIPSREFERMAEITVSMLHRSLSAFIKEDATLAHRIPEEDEQVDELYNNVYRGLISSMIEHPEWIDHTNLLLWVAHNLERAADRVTNICERTVFIATGELLEMDLDDYEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1D9</accession>
    <name>E8N1D9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64882">
        <property type="protein sequence ID" value="BAJ64882"/>
        <property type="gene ID" value="ANT_28560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28560"/>
    <dbReference type="HOGENOM" id="CLU_1109634_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="250" mass="26506" checksum="F7982DB37829AB5C" modified="2011-04-05" version="1">MNTSYLNINCKKSLRFSTRRASIGSFGKWILGVIMSRKHVMLIVFSGVFLGLALLLSSSLSLAQLVEQSSPSSGWDEGRQVTSNLTQSQSSLAAVPTTPGTTYKTFSGGAFSPTNSSLTYSAQGGAVYATALPPGGFSFSLELDLPQGAKITEVVFFVVDNDTASNMDLGLRSYNPETNSFSALETASSSGASTSLQTIVVPVDPPVQVDNTTTSYRLRVAPRVASSAHLLRGARIGYIVSQVYLPSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E8</accession>
    <name>E8N1E8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64891">
        <property type="protein sequence ID" value="BAJ64891"/>
        <property type="gene ID" value="ANT_28650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28650"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529613_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="514" mass="56018" checksum="40D3AC4BBD14093A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P4</accession>
    <name>E8N1P4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559044.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62649">
        <property type="protein sequence ID" value="BAJ62649"/>
        <property type="gene ID" value="ANT_06150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06150"/>
    <dbReference type="HOGENOM" id="CLU_417192_0_0_0"/>
    <dbReference type="OrthoDB" id="2017492at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="657" mass="74494" checksum="935F6BCB5F01B2C3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V4</accession>
    <name>E8N1V4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559103.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06750"/>
    <dbReference type="EnsemblBacteria" id="BAJ62709">
        <property type="protein sequence ID" value="BAJ62709"/>
        <property type="gene ID" value="ANT_06750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06750"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587770_0_0_0"/>
    <dbReference type="OMA" id="KNCSIDP"/>
    <dbReference type="OrthoDB" id="710779at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="425" mass="47593" checksum="6F6B947A348BFF39" modified="2011-04-05" version="1">MLKIILRNPQHIVPFNEPARDLRIQNKPLWLLQRDVLAPYTTREIELPPGAPLPQVHEPCIVYRDNLFFDAPYMEAFISEARKRGKAVRAAFNASDPCFREHILPLSLSYTPAGNLYLADLWYYPNGPEPGAEPLVIDLLSREIGYYHIPLYMAPSQGDLVYQVPLRSLMAIDSWVHIFIADEVFGLFGRGARFEERLNRDLWFKLKVLGTALYEGRQLLRSSAVVQIGRNCVIDPDAIIHGPTTIGDNVTIGANAVIENCIIGDNVNISQGCQLMLSVVGDGTFLPFRASLFMTTVMENSLIAQNTCLQMCVVGRNTFIGAGSTWTDFNLLSAPIKARDGTGALRNSNRIVLGGCVGHNCRIGAGMLVYPARTIESDVVIFSTKERRVIDRDLYYEDSDHLRLPNAHLHPRLYPRPGEKGSETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Y4</accession>
    <name>E8N1Y4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c-type protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nrfH</name>
        <name evidence="12" type="ordered locus">ANT_29050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="9">Binds 4 heme groups per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Binds 4 heme groups per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NapC/NirT/NrfH family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561275.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64931">
        <property type="protein sequence ID" value="BAJ64931"/>
        <property type="gene ID" value="ANT_29050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29050"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096753_0_2_0"/>
    <dbReference type="OMA" id="ACINCHV"/>
    <dbReference type="OrthoDB" id="1683334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019333">
        <property type="term" value="P:denitrification pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024717">
        <property type="entry name" value="NapC/NirT/NrfH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005126">
        <property type="entry name" value="NapC/NirT_cyt_c_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017571">
        <property type="entry name" value="NrfH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03264">
        <property type="entry name" value="Cytochrom_NNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000013">
        <property type="entry name" value="4_hem_cytochrm_NapC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03153">
        <property type="entry name" value="cytochr_NrfH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrom_NNT" evidence="11">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>a menaquinol</name>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>a menaquinol</name>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>4</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000013-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000013-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="156" mass="17564" checksum="FE521A2A4B2F5782" modified="2011-04-05" version="1">MRLPILVGVICLIAVLGVGMWVSNFTVYLGDDPTTCNNCHVMDDVYEGWYHAGHKAWATCNDCHTPHAFIPKYLVKARSGFNHVTAFTFGHIPSPLRAKPSTDKIIQENCIRCHEDTVETIMAGPMQEERYCFECHRSVAHGARGISILPYQDKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N213</accession>
    <name>E8N213_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rmlB</name>
        <name evidence="7" type="ordered locus">ANT_29340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561304.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29340"/>
    <dbReference type="EnsemblBacteria" id="BAJ64960">
        <property type="protein sequence ID" value="BAJ64960"/>
        <property type="gene ID" value="ANT_29340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29340"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_0"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="6"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="362" mass="40850" checksum="CEF653A252B26E36" modified="2011-04-05" version="1">MPHSLLVTGGAGFIGSNFVRYLLAHDPDVRIVNLDLLTYAGSLENLKDLPDPARHTFVQGDICDRALVEDLFRRYQVDTVVHFAAESHVDRSILGPAQFIQTNIVGTFTLLEAARQAWLKEGIVPVEQARFHHVSTDEVFGSLEPHDPPFTETTPYNPRSPYSASKASSDHLVRAYHHTYGLPVSITNCSNNYGPYQFPEKLIPLMIFNALNGKPLPIYGDGQQVRDWLYVEDHCEAIWKVVCEGKLGETYNIGGGNNPANLQVVHTLCDILDELLPHSPHAPHRSLIQFVADRPGHDRRYAMDIRKIQRELGWSPRETLASGLRKTVQWYLSHPDWIEAIRQTSDLSGWMEKNYARRGGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N267</accession>
    <name>E8N267_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ordered locus">ANT_29880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561358.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29880"/>
    <dbReference type="EnsemblBacteria" id="BAJ65014">
        <property type="protein sequence ID" value="BAJ65014"/>
        <property type="gene ID" value="ANT_29880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29880"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_1_0"/>
    <dbReference type="OMA" id="NSEYHSA"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="84"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ65014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="155" mass="16995" checksum="A80D8B68F2FC3794" modified="2011-04-05" version="1">MPTTPFLTREGYAKLQEELEYLRTKKREEIAQRLHEAMEGGELIENAEYEAAKNEQAFVEGRIKELEYLLASAKIIEEGGTHGNVVQVGSRVTIQEEGAEPEVYTIVGAAEANPVLGRISNESPLGKALIGKKAGDNVQVDAPQGSFRVTILKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C2</accession>
    <name>E8N2C2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_06940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06940"/>
    <dbReference type="EnsemblBacteria" id="BAJ62728">
        <property type="protein sequence ID" value="BAJ62728"/>
        <property type="gene ID" value="ANT_06940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06940"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972456_0_0_0"/>
    <dbReference type="OMA" id="DDREHYR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="288" mass="32047" checksum="38313580C86CC9D6" modified="2011-04-05" version="1">MMPLMKRSIPLRSFLTAAWLGWQIESNWTDPFLFATYSIVKPVAGAAILVIMYAIVTQAQFDSPVFAYLFLGNALYQYVPAVLSGVSWTIIDDREHYRTLKYIYVAPVNIPFYLFGRAVAKFIIGTIGVVITIAAGVLFLHVRIDWAQVNWGLFFLSLVLGIIMMALLGLILAGVTLLSARHSYFIGDVVAGGLFLFTGAIFPLEVLPVWLRPVGYALPITYWLELLRRALVGEVAQAFPTFATLSNETLLLVLVGSSLVFGAASLFIFRRCDFLARERGNLDITTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D0</accession>
    <name>E8N2D0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07020"/>
    <dbReference type="EnsemblBacteria" id="BAJ62736">
        <property type="protein sequence ID" value="BAJ62736"/>
        <property type="gene ID" value="ANT_07020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07020"/>
    <dbReference type="eggNOG" id="ENOG502ZCWZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079845_0_0_0"/>
    <dbReference type="OMA" id="IRHRWRT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="13364" checksum="971CB4BC51E4ED72" modified="2011-04-05" version="1">MAMEIARLIERIQQKIAEVESLYQRQSGGASFCQVQRDGRVTGGLKYEEGRMVALHFARRALQQRGEAGLADIEEEEQTWLKALADLQAKPSLPMLWLAYRQGGVDAFHWLREQFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D9</accession>
    <name>E8N2D9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_07110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559139.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62745">
        <property type="protein sequence ID" value="BAJ62745"/>
        <property type="gene ID" value="ANT_07110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07110"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_4_1_0"/>
    <dbReference type="OMA" id="RDQSFLM"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="35614" checksum="D09F8AB319FEC723" modified="2011-04-05" version="1">MKKQFSLSRWIDEFGFVTRKYAPLMILISLVIFFSITTPNFMTAKNLVIIIRQVSFAAISAVGMMFVMIGGAIDLSLGSQIVLTNIVLSILMVDYKVPMALAIPLILVLGTLLGTINGFLAVKLKIHPLIITLGTASIYKGIGYILAHSRNIMGFPDAFRWFGQGFIGPIPVPIVVMIIVALIGSFILTRTYFGRYIFALGGNEEAARLAGVNVDAMKVILFAICGFITSITSVLLLSRVFAGQTSTGQGLEFDCLTAALLGGVSFKGGEGTIFGLITGILIIGVLNNAMQLASFPDFSQNVVKGAVLLIAVGFDVYQKNRKAKETVAKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I8</accession>
    <name>E8N2I8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559187.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62794">
        <property type="protein sequence ID" value="BAJ62794"/>
        <property type="gene ID" value="ANT_07600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07600"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_4_0_0"/>
    <dbReference type="OMA" id="WRTRAYG"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="259" mass="28664" checksum="16A32C2BB1FAB011" modified="2011-04-05" version="1">MTTSLRDLLDFAVETAYLAGRTTLAYFQTGVQAEFKADSSPVTLADRAAEQLIRQRIEKRFPHHAIVGEEFGVQGSADATHRWFIDPIDGTKSFLRGIPLYAVLLGLEIEGRVQVGVAYYPAMDEMLSAADGEGCWWNGRRARVSTASRLAEAWVTSTDPYNFQKTGKDAAWQRIQAVSYHRGGWGDAYGYLLVATGRAEVMLDPIMNEWDCAPFPPIFREAGGFFGDWQGNETIYGGEALATTQVLLPEVLECLHSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J0</accession>
    <name>E8N2J0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07620"/>
    <dbReference type="EnsemblBacteria" id="BAJ62796">
        <property type="protein sequence ID" value="BAJ62796"/>
        <property type="gene ID" value="ANT_07620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07620"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507630_0_0_0"/>
    <dbReference type="OMA" id="EKWQWMA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="64"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="178" mass="20410" checksum="C731A4341C83664C" modified="2011-04-05" version="1">MDGAVFCFLLQFFAEFLEKTSHALDLELTPGCINKVSSIYHQRAFLRKGKIKMTKREQELIQLSSEKWKWMAERNLPALENLFHEKAVFVHMGGTLTREKELEVIQTGAIHYKETEIQEVSVRFVSRTTAILLNKIRLLAVVGGNEVVNPFVVTEVYVRQGGKWLLASLSFTRLLTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2R5</accession>
    <name>E8N2R5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561406.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30390"/>
    <dbReference type="EnsemblBacteria" id="BAJ65065">
        <property type="protein sequence ID" value="BAJ65065"/>
        <property type="gene ID" value="ANT_30390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30390"/>
    <dbReference type="HOGENOM" id="CLU_1552110_0_0_0"/>
    <dbReference type="OrthoDB" id="2130034at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="172" mass="18462" checksum="6D9BE43D5141AA7D" modified="2011-04-05" version="1">MTAQISQNTPPPVAASNSVTRPYRYWHRRARTGLILTLFGFLVFLMGARPGLFGLDRSPVIGFVQIAVFLIGLAIICIGGYISLLALWKGDPLSIAADIGQRLVATGYVIAVFAGMADIFGMGSHALPGIPYFGEWQARGVEVGQLLIAIGFILMLPFGRNKPTPPPQPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y7</accession>
    <name>E8N2Y7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31110"/>
    <dbReference type="EnsemblBacteria" id="BAJ65137">
        <property type="protein sequence ID" value="BAJ65137"/>
        <property type="gene ID" value="ANT_31110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31110"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127258_0_0_0"/>
    <dbReference type="OMA" id="YHVISAT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="129"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="27590" checksum="4ED36C56711A8F47" modified="2011-04-05" version="1">MSAYRVLLVDDSPQFLQSASSLLRSIHGVELVGTAGTLAEAVKQAERLAPDLILLDLILPDGNGIEAARQIRQNNPQASIVILSIYDMNDYREAADAVGVLDFIPKQELSETLILSWLNRSPKEKVRRRILVVDDSPTIRRMIITALKPLEADFEEASNGLEALEKMTLMSFDLVTLDINMPDMHGMEVLQFIRKVDRLKDLPVIMLTTRGDEESLQEAMSLGANRYLTKPFSPSSLLRTVEELWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z4</accession>
    <name>E8N2Z4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561485.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31180"/>
    <dbReference type="EnsemblBacteria" id="BAJ65144">
        <property type="protein sequence ID" value="BAJ65144"/>
        <property type="gene ID" value="ANT_31180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31180"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_0"/>
    <dbReference type="OMA" id="WNLLETR"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="120" mass="13276" checksum="7795C4567651E670" modified="2011-04-05" version="1">MTRILLIDDSRYARSTLKQALGEGYQYLEAADALSGLELYFLEKPELVILDLTMPGMNGLEMLAQLKAIEPAARVIVCSADVQEFSQQEALRLGAARFLAKPIAPEHLRTAVSEVLEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N301</accession>
    <name>E8N301_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation-transporting ATPase</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_31250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31250"/>
    <dbReference type="EnsemblBacteria" id="BAJ65151">
        <property type="protein sequence ID" value="BAJ65151"/>
        <property type="gene ID" value="ANT_31250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31250"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_1_0_0"/>
    <dbReference type="OMA" id="GVHRMAK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="803"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ65151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="940" mass="102383" checksum="63B63F7D629504AE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G0</accession>
    <name>E8N3G0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_09400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559365.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09400"/>
    <dbReference type="EnsemblBacteria" id="BAJ62974">
        <property type="protein sequence ID" value="BAJ62974"/>
        <property type="gene ID" value="ANT_09400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09400"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131753_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="26695" checksum="44E4665554FCE10D" modified="2011-04-05" version="1">MNRQSLYCPTPWMNAAGTLGFLPSKAWNLPEAQGVFVTNPLSLHPRTPAAQRIALTDAGNLLVHSGLPNPGLVTALRRYARKWEKSPIPVWVHLIPQSPEECYRMIHLVENSAGVSAIEISLPPRLSTGEKQAFLSAMDSELPIVLVLPLNGEEIPVPLDRISAVTLSAPRGMLPSPSGAWIEGRLFSISLFPQMLYAVKQVVQHGIPVIAGAGIYRRAHAQHLLQAGAMAIQVDTVLWKGFLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L5</accession>
    <name>E8N3L5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_09950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559420.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09950"/>
    <dbReference type="EnsemblBacteria" id="BAJ63029">
        <property type="protein sequence ID" value="BAJ63029"/>
        <property type="gene ID" value="ANT_09950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09950"/>
    <dbReference type="eggNOG" id="COG1090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047373_0_2_0"/>
    <dbReference type="OMA" id="YMPWIHI"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="298" mass="32858" checksum="400F8FDDE81198F9" modified="2011-04-05" version="1">MAKVIVTGGSGLIGQAFCREMHNAGWEVVVVSRNPQQASPVESFCRIGWEDLSHEMESAHAVVNLAGENIGAGRWTEEKKQRIRESRIKAGEAVLQAFRQVSRKPTVLMQSSAIGFYGIQHGDTPLDETASAGKDFLSLVGVAWEDSTREVENLGVRRVVIRTGVVLAREGGVLGRMVLPVRLGAGGPLGSGKQWISWIHLQDQVRAMRFLIETPSSRGVYNLSAPHPVQNRDFMRTLAKVLKRPYWLPVPAFALRLLLGEMSTLVLDGQRVIPARLLAEGFKFVYPELEGALQNLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L7</accession>
    <name>E8N3L7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low molecular weight protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_09970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559422.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63031">
        <property type="protein sequence ID" value="BAJ63031"/>
        <property type="gene ID" value="ANT_09970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09970"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_1_2_0"/>
    <dbReference type="OMA" id="AFFPQKA"/>
    <dbReference type="OrthoDB" id="2062716at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="162" mass="17854" checksum="93D0B4C66A4D18C4" modified="2011-04-05" version="1">MPAVLFVCTANICRSPMAAALFSARLRADGLRPEEWLVDSAGTWAHDGQAASQNAVLAMQKRGLDLRSHRSKTVSSYLLEMFDLILVMEPGHKEALQVEFPHLAERIYLLTEMVGEHLPVEDPFGASLEEYEKTAAEIDAYLEKGMPRILALVGFHGKVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M5</accession>
    <name>E8N3M5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplD</name>
        <name evidence="7" type="ordered locus">ANT_10050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559430.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63039">
        <property type="protein sequence ID" value="BAJ63039"/>
        <property type="gene ID" value="ANT_10050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10050"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_0"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="208" mass="22944" checksum="04E1FA8504D248A9" modified="2011-04-05" version="1">MLVDVVNMQGQKVSSVELPESIFEAPIYIDLMHQAYVRQMANARLGTHDTKTRNEVSGGGRKPWRQKGTGRARQGSTRSPVWAKGAKVHTPHPRSYVQLMPRKMRRAALRSALSVKAAENAIVVVDQLTLPEAKTRHMAQALNTLVGDASALVLIPEKEAYEGVIRSTRNLPDAKILLANYLNIRDLLMFDKVVMPLAALDVISANLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Q5</accession>
    <name>E8N3Q5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsI</name>
        <name evidence="8" type="ordered locus">ANT_10350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63069">
        <property type="protein sequence ID" value="BAJ63069"/>
        <property type="gene ID" value="ANT_10350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10350"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_0"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="131" mass="14460" checksum="BBF8C3D7F7218626" modified="2011-04-05" version="1">MSVQYYEGVGRRKEATARVRVMSGNGKFIVNDKPAEDYFTRLGDLEAILAPLAAAGEDRSRLDITVQVKGGGVTGQTDAVKLGMARALVKMNADLVAVMRKYGFLTRDARVKERKKPGLKRARKAPTYTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3U9</accession>
    <name>E8N3U9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cobalt ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_10790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559503.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10790"/>
    <dbReference type="EnsemblBacteria" id="BAJ63113">
        <property type="protein sequence ID" value="BAJ63113"/>
        <property type="gene ID" value="ANT_10790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10790"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_2_0"/>
    <dbReference type="OMA" id="NNIMIGR"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="273" mass="30007" checksum="7A3C20D24CBCF3D0" modified="2011-04-05" version="1">MSRFEFLRSVPIGQYMPVDSLLHRLDPRARLLGYAWLVLALTFSFQLRGLLLGIGIGLLGLWLGHIPLRFALRAMASPLPLILFLAVLQVFLNTSPTDSPVLVPLGRFSITRADLLAGGLLLLRFTGLVLILSLLSFTLSTSEMSHGLNALLKPFDQLGLPAQDLGMMVQVTLRFLPLLAQTAERIAKAQVSRGADWEGKRGGLLQRVRQVLPLIVPLFLASLHRAENMALAMDARAYGCVRDRGSFYAYRFTGKDFLALVLMGATGILILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X0</accession>
    <name>E8N3X0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_11000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63134">
        <property type="protein sequence ID" value="BAJ63134"/>
        <property type="gene ID" value="ANT_11000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11000"/>
    <dbReference type="eggNOG" id="COG1933">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010640_0_0_0"/>
    <dbReference type="OMA" id="GWILWYQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="4">
        <location>
            <begin position="85"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1225" mass="139983" checksum="D89FA4E5252F23A8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N460</accession>
    <name>E8N460_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_11900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559612.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63224">
        <property type="protein sequence ID" value="BAJ63224"/>
        <property type="gene ID" value="ANT_11900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11900"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046535_1_2_0"/>
    <dbReference type="OMA" id="WDAFVTM"/>
    <dbReference type="OrthoDB" id="1977328at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228167" evidence="3">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="312" mass="34234" checksum="86535298676A9CCB" modified="2011-04-05" version="1">MKRIWIALLGMVFLLSACSPARSFAPVPGETQRNAITGADMSKGVSAPAYEGVESASLVVPSESAADRLVIRNADLRIVVDDPVSALDEISQLAEKMGGFVVQSNLYKTQTEEGVETPEASITIRVPAERLNDALAQIKSLVKDKNTDILSENVSGQDVTKEYTDLKSRLTNLENTEKQLQRIMEEATKTEDVLAVYNQLVSVREQIEVLKGQIKYYEESAALSMISVTLKASATVKPLTIGKWQPIGVARDALQATLKTYKFLANAAIWIVLYFIPVAVVIILPIWLIIHGLRRLSTRKSKSSQSDESLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C7</accession>
    <name>E8N4C7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559679.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12570"/>
    <dbReference type="EnsemblBacteria" id="BAJ63291">
        <property type="protein sequence ID" value="BAJ63291"/>
        <property type="gene ID" value="ANT_12570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12570"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_0_0"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="139" mass="15038" checksum="61C1CDD0A5CE1126" modified="2011-04-05" version="1">MFKQILLAYDGSEYSRRAAELAGKLAREQKDCVVRIVCAVGDVPWGSSDPMAERWIAEQTLEGNRLIDEASALVGNGVEIRRELVFQSPAEGILNVAETHQCDLIVIGTKGKGGFAGLFMGSQTQKVISMANCPVLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F3</accession>
    <name>E8N4F3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63317">
        <property type="protein sequence ID" value="BAJ63317"/>
        <property type="gene ID" value="ANT_12830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12830"/>
    <dbReference type="HOGENOM" id="CLU_3163990_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="47" mass="5357" checksum="ECEF9516EE6D960F" modified="2011-04-05" version="1">MPSLEEEEGLLFFGLDFGLFTENPYPKVSSRHIIAHAFYLKAKVNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G1</accession>
    <name>E8N4G1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">npdA</name>
        <name evidence="4" type="ordered locus">ANT_12910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63325">
        <property type="protein sequence ID" value="BAJ63325"/>
        <property type="gene ID" value="ANT_12910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12910"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_0_0"/>
    <dbReference type="OMA" id="ERDCHGL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="229" mass="25951" checksum="6CB76DA502C3E055" modified="2011-04-05" version="1">MAFTGAGISTPSGIPDFRSAGSGLWERFDPMEVASLGVFLSNPRKFWDWKRPLLRQIWAVQPNDAHRALAEMERQGILRAVITQNIDQLHQRAGSQTVLELHGSIDRLECLKCQATFPMEDFREFLETSEDMPRCPRDSSVLKPTIVLYQEMLPADTWLKAEEHTRQADCMLVIGSSLEVFPANELPRRVVERGARLMINNLSPTRLDNLATLVLPWDVCKVIPLLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I7</accession>
    <name>E8N4I7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ordered locus">ANT_13190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559738.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63351">
        <property type="protein sequence ID" value="BAJ63351"/>
        <property type="gene ID" value="ANT_13190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13190"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_3_1_0"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="208" mass="23804" checksum="7023425D6FA5F912" modified="2011-04-05" version="1">MAGLTLSRVGVFGGTFDPPHMAHLALAEEALHQLNLSQVLWMITPNPPHKRGVEITPFVLRLEMLKEALKDYARFEISTLEAELPPPQYAVETVRLLREKLPDSELFYLMGEDSLRDLPLWHQPAKLVSLLDGIGVLRRPEVVLDWEILETSLPGLREKVFFFNAPLLQIASHEIRQRISSGQPYRYMVPEGVARIIEQYHLYQFPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K0</accession>
    <name>E8N4K0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_13320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559751.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63364">
        <property type="protein sequence ID" value="BAJ63364"/>
        <property type="gene ID" value="ANT_13320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13320"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108925_0_0_0"/>
    <dbReference type="OMA" id="THVESAH"/>
    <dbReference type="OrthoDB" id="1875455at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="111"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="111"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="24878" checksum="957592C63F485B73" modified="2011-04-05" version="1">MTQSGSEAPLLVASIGPLSGQRWTMDKALLIGRDPSCDIVIPDRQISRYHARISPTPNGAILEDLGSKNGTYYLGKRVEDPVSLQDGDAFQVALVQHFTFLISDATLPLGNAFISTQATKYRLRLDERSRRLWLNGKEVLPPLSAQQFRLLQALERQQGEVVSREELIQAVWGDEAFGVTEQAFDALVRRLRERLAEIDPHHNYILTIRGHGLRLDNPPVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K3</accession>
    <name>E8N4K3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_13350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559754.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63367">
        <property type="protein sequence ID" value="BAJ63367"/>
        <property type="gene ID" value="ANT_13350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13350"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_2_0"/>
    <dbReference type="OMA" id="PKPWVET"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="313" mass="34211" checksum="AC538135C01DEC49" modified="2011-04-05" version="1">MIFPWEWLEQAYQRLQDKVIQTPLTQDEVAAITLKWENQQITGSFKVRGALNRALTLQPWEIEKGLVCASAGNHGQGVAYAAKLLGASCIVFTYEGASAHKIEQMRQLGAKVHIVPGHYADAERAGLEYARSHQATWISPYNDPQVIAGQATVGLELIEQWKAEIPASVVVPVGGGGLAAGIALAMQRLPHPPKVIGVQSEASAYFHALFHQNNKKEVVEWESLADGLAGDVEDNSITIPLVKTHLFDLRLVSEKEIAEAIRFAWQRYGERIEGSAAVTLAAVLSRKVDELPATLIISGGNIDPQIFENILHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4P8</accession>
    <name>E8N4P8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559796.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63412">
        <property type="protein sequence ID" value="BAJ63412"/>
        <property type="gene ID" value="ANT_13840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13840"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_961865_0_0_0"/>
    <dbReference type="OMA" id="EWFGFRR"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="153"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="289" mass="33229" checksum="C12568DD2D51EF22" modified="2011-04-05" version="1">MNWFQRHHHLRPVTPEDKPSLQTFLRKTIYLHQHLDWRNALDWVGWQPFWLAEKDSQIIGFLASPADPPLASWIRIFAADLFVSPSRVLVELLEKNVEWHREYGKVSFIASLGLSDWFSHLLQDSGFHHHQDVVMMTYDLNFVSCQTPLLRDGIIREMGFEDLPLVTAIDHAAFEPLWQLSQIDLSNAFQKCTYKTVLEVNGKLVAYQMSTESESKAHLARLAVSPEMQNKGLGAALIRDLLEHFILHKGLQSVTLNTQSTNAASLHVYQRCGFHLTGEQFPVFILPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N538</accession>
    <name>E8N538_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559934.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63552">
        <property type="protein sequence ID" value="BAJ63552"/>
        <property type="gene ID" value="ANT_15240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15240"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113198_2_2_0"/>
    <dbReference type="OMA" id="CYGLVGM"/>
    <dbReference type="OrthoDB" id="1961470at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="12702" checksum="047236A2D592A632" modified="2011-04-05" version="1">MKDSNPLGNIFVSYRAIATVAYQSALSSYGVVGFAAKNLAEGLAQVLVKDPTLGVDVRYVNNSIQIDLYIIVEYGTRIKMVASSVADNVRYQVEKTIGIPVSQVNVHVRGLRVSNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N541</accession>
    <name>E8N541_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recG</name>
        <name evidence="9" type="ordered locus">ANT_15270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559937.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15270"/>
    <dbReference type="EnsemblBacteria" id="BAJ63555">
        <property type="protein sequence ID" value="BAJ63555"/>
        <property type="gene ID" value="ANT_15270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15270"/>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_0"/>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="397"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="586"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="816" mass="92547" checksum="5B54DBF16E7883BA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A8</accession>
    <name>E8N5A8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dgt</name>
        <name evidence="3" type="ordered locus">ANT_15960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560002.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63622">
        <property type="protein sequence ID" value="BAJ63622"/>
        <property type="gene ID" value="ANT_15960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15960"/>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028163_1_0_0"/>
    <dbReference type="OMA" id="KLAECGD"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016793">
        <property type="term" value="F:triphosphoric monoester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="76"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="383" mass="44832" checksum="80B640E819ABC7D3" modified="2011-04-05" version="1">MAYTRERLEEIEEQTLAPYAIKSRNSRGRKYPEDEAPYRTCFQRDRDRILHTTAFRRLEYKTQVFINYEGDYYRTRLTHTLEVAQIGRSIAVALGANEILTEAICLAHDLGHPAFGHSGEQTLSRLMKDFGGFDHNKQSLRIVTELERRYPEFPGLNLSWEVLEGIVKHETEYDIADARDFNPELRGHLEAQIANIADELTYTAHDLDDGLRSGMITVDMLQGLSLWEIVCESIGWKGGTLTDMTRHQIIRRLIGMTVNDIIQSTEQRLRESLVRSVEELQRLPYNVVSLSEDMRRRSRELKDFLYKNLYRHWRVVRMAVKAERIISDLFNAYREEPTILPKHVQENIPKWGLERTICDYIAGMTDRYAIEEHQKLFDPTRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C2</accession>
    <name>E8N5C2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rny</name>
        <name evidence="8" type="ordered locus">ANT_16100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560016.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16100"/>
    <dbReference type="EnsemblBacteria" id="BAJ63636">
        <property type="protein sequence ID" value="BAJ63636"/>
        <property type="gene ID" value="ANT_16100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16100"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_0"/>
    <dbReference type="OMA" id="PHAILGM"/>
    <dbReference type="OrthoDB" id="1012190at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="328"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="66"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="512" mass="58121" checksum="6AE47702133F4BF8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C9</accession>
    <name>E8N5C9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ahcY</name>
        <name evidence="9" type="ordered locus">ANT_16170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560023.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16170"/>
    <dbReference type="EnsemblBacteria" id="BAJ63643">
        <property type="protein sequence ID" value="BAJ63643"/>
        <property type="gene ID" value="ANT_16170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16170"/>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_0_2_0"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="186"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="215"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="419" mass="46028" checksum="7913C2392EBBBB47" modified="2011-04-05" version="1">MSGFDIKDPKLAEGGRLRIEWAEREMPVLRSIRERFAKERPLSGVRISACLHVTTETANLMRTLQAGGADVVLTASNPLSTQDDVAAALVNVFEIPTFAIKGEDNVTYYKHLRAALDHQPHLTMDDGADLVSTLHKERRDLLSNVLGGTEETTTGVIRLRAMAADGALAFPIIAVNDALTKHLFDNRYGTGQSTIDGIVRATNVLLAGKVFVVAGYGWCGRGLASRARGMGSNVIVTEVDPLKALEAVMDGYRVMPMTEAAKIGDIFCTVTGDINVIDRHHFELMKDGAIVANSGHFNVEINIPALEELSQGKRLVRPFVEEYTLKDGRRIYLLGEGRLINLASAEGHPASVMDMSFANQALSVEYMLKHHAELEKKVYSVPEVIDQEIARLKLESMGIEIDTLTPEQVQYLNSWEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E3</accession>
    <name>E8N5E3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltrans_SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_16310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63657">
        <property type="protein sequence ID" value="BAJ63657"/>
        <property type="gene ID" value="ANT_16310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16310"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051804_1_0_0"/>
    <dbReference type="OMA" id="PEQAVNW"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="89"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="312" mass="35794" checksum="0449A8A4CB37F9DC" modified="2011-04-05" version="1">MIYFHPKMNAKTDLEPQLLYPQSWSEYELLDCGNGYRLERFGVFRVIRPDAEAIWAPALPEREWKAIHARYIPAPEENGGHWEKIKPIPERWQIHYKDLRFWLQMGGSKHLGVFPEQAVQWDWIQEQIKAFAKPVRVLNLFGYTGLSTLAAASIGASVTHVDASRKAITWARENQILSGLENKPVRWLIDDALKFVQREARRGVTYEGMILDPPKFGRGPKGEVWEFYKLLPELLQVCQAVLSPQPCFVVLTAYAVKASPITMYYAIEDMLKGKGGHIEVGEVALKESNPRGRLLATALFARWTYQKRGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G8</accession>
    <name>E8N5G8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_16560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560061.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16560"/>
    <dbReference type="EnsemblBacteria" id="BAJ63682">
        <property type="protein sequence ID" value="BAJ63682"/>
        <property type="gene ID" value="ANT_16560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16560"/>
    <dbReference type="HOGENOM" id="CLU_1493244_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="20360" checksum="0DA47557A34E36B5" modified="2011-04-05" version="1">MSEQPAGTTPRLEADEKISHVMIYTLSGIYWGELITKSIIRVSTWLRTNAVPDRITLHNAKGMITTGGQVSPTSYTELHISLSQIQAFHLIPPEQDPIDYDPTEPNRKMEPVLILLSSFQFKGYLRLSTTSTVKKFLDVTHELYTPIYDAEITNLLLPNLGSIKVPYTLIRQETAIFAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H2</accession>
    <name>E8N5H2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="3 9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">tig</name>
        <name evidence="13" type="ordered locus">ANT_16600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560065.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16600"/>
    <dbReference type="EnsemblBacteria" id="BAJ63686">
        <property type="protein sequence ID" value="BAJ63686"/>
        <property type="gene ID" value="ANT_16600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16600"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033058_3_1_0"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger_C" evidence="12">
        <location>
            <begin position="274"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="447"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="489" mass="55626" checksum="314B5A17ED39192A" modified="2011-04-05" version="1">MKLEILDRDDHQKQIVAEFDSETLEKFKRQAARKISERTKIPGFRPGKAPYEMVRRIVGDGVILEEAIEILIDEAYPKILDETKIEPYGPGKLDEIISMEPPKFSFLIPLQPEVDLGNYREIREEYTPPEVADEDVEKILNRLRRRAGTAVPVERPAQQGDLVAIKMSAHLINPEEGQEKILIEENNFEMIAGVSEEHTDEEGYEWPFPGFVQELIGVSAGEKKVVKHTFSASDFSDDLAGQEAEFVFEVESVKEIVLPELDDSFAHLMGPYETLEALKNDIRQQLLSGKLQEYQRNYVDRVVDRLVEGATVKYPPVMVEDEVEHLLRHLEEDLGKQQMDLEAYLKARQITREELIEKEIRPAAEANVKRNLVLEEFARQEQIQIKASEIQTIYDIALNQARTDKELRQLAGKSMNTKQLADTMARMSINEIFNQRMINRLHAIATGKADEQPEATEEGSPSEEIGTTDTTESLEPSDEAKADASQPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J6</accession>
    <name>E8N5J6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">alaS</name>
        <name evidence="11" type="ordered locus">ANT_16840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560089.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63710">
        <property type="protein sequence ID" value="BAJ63710"/>
        <property type="gene ID" value="ANT_16840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16840"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_0"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="10">
        <location>
            <begin position="4"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="911" mass="101317" checksum="306AB0223B9E9311" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L8</accession>
    <name>E8N5L8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560111.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63732">
        <property type="protein sequence ID" value="BAJ63732"/>
        <property type="gene ID" value="ANT_17060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17060"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_0_0"/>
    <dbReference type="OMA" id="TMCVREY"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="244" mass="27368" checksum="4ABDCC30DB266612" modified="2011-04-05" version="1">MKAVVLAGGKGTRLAPYTRIIPKPMLPVGDRAILEIMLLQMKRAGIEEVILTVGHLSGLMKAYFQDGQQLGLRICYSYESHPLGTAGPLALIEGLEETFLVTNGDVLTTLSLTDLIKFHDQSGGIATIATHRRKVFIDLGVIHVNGGHEIVDYIEKPTLEYQVSMGIYVFEPRVLRYITKGEYLDFPDLVKNLLAVGEKVVAYPFDGYWKDLGRPDDYEQANLDFEQIRNQILPEEPTWNGEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R1</accession>
    <name>E8N5R1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="4">HAT</shortName>
            <ecNumber evidence="4">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Homoserine transacetylase</fullName>
            <shortName evidence="4">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">metA</name>
        <name evidence="4" type="synonym">metAA</name>
        <name evidence="6" type="ordered locus">ANT_17490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560153.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17490"/>
    <dbReference type="EnsemblBacteria" id="BAJ63775">
        <property type="protein sequence ID" value="BAJ63775"/>
        <property type="gene ID" value="ANT_17490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17490"/>
    <dbReference type="eggNOG" id="COG1897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057851_0_1_0"/>
    <dbReference type="OMA" id="WLWFCYQ"/>
    <dbReference type="OrthoDB" id="1601420at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019281">
        <property type="term" value="P:L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03131">
        <property type="entry name" value="GATase1_HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00295">
        <property type="entry name" value="MetA_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005697">
        <property type="entry name" value="HST_MetA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20919">
        <property type="entry name" value="PTHR20919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000450">
        <property type="entry name" value="H_ser_succinyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01001">
        <property type="entry name" value="metA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4 5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000450-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="35805" checksum="C8ECA076318C5B4B" modified="2011-04-05" version="1">MPIRIPVNLPAREILLQENVFVMDEERADHQDIRPLKIAILNLMPTKIATETQLLRLLGNTPLQVEITFMRTSSHQSKNTPEEHLLAFYQTFDELSHLKFDGLIITGAPVEHLEFEEVDYWKELTEIIDWSGVHVTSTFFICWGAQAGLYHQYGIPKYALPRKMFGVFEHYALRNHIPLLRGFDDVFYAPHSRHTEIRKEDIQKVPDLEVIAESPLAGVYIVMRRDGRQIFVTGHSEYDPLTLQSEYERDVRLGKPIHVPLNYYPADDPSRPPVVRWRGHSHLLFANWLNYYVYQVTPFNLDDLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V2</accession>
    <name>E8N5V2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560194.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63816">
        <property type="protein sequence ID" value="BAJ63816"/>
        <property type="gene ID" value="ANT_17900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17900"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061439_0_0_0"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="38"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="266" mass="30373" checksum="A35E636595E2D466" modified="2011-04-05" version="1">MKIEYHETTNDLQTRINIHNQFGARDIDAWMLEILPLQKGMHILDVGCGAGKQCFSFYDHLGGEATILGGDVNQELLAQARQTAEKTNRKVKFFELNFNKAFPVESEQFDLVSCCFAIYYAENIPFTIEQMHRVLKPGGRLFTTGPMPTNKQVFYDIIREATGKPIPPMPGSSRYSTEIYSAIEKLFSKVETYIFENPLTFESVEPFLAYTRASLSEDRKLWNSLFQTKEEFEAIMKQIEQVAKARIEHDGKLIMTKVVGGFIATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z1</accession>
    <name>E8N5Z1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <ecNumber evidence="2">1.11.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpx</name>
        <name evidence="2" type="ordered locus">ANT_18290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63855">
        <property type="protein sequence ID" value="BAJ63855"/>
        <property type="gene ID" value="ANT_18290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18290"/>
    <dbReference type="eggNOG" id="COG2077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_12_0_0"/>
    <dbReference type="OMA" id="ITQEPNY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="29"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="20314" checksum="31E3425FB1F873E9" modified="2011-04-05" version="1">MFFLRGTMKERYGLIQFLGKDTPVIGEDILPGQQAPEFHAVTQNWEYIPVLESTKGKVRIIAAVPSLETSVCDRETRRFNEEAAKLGKDVVIIVISTDLPFTQKRWCGAAGIDQVWVVSDHREVEFGTRYGCLMKEPRILRRAVFVVDRNDKVTHVEYMAALGEEPDYERVLEAAKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N601</accession>
    <name>E8N601_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560242.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63865">
        <property type="protein sequence ID" value="BAJ63865"/>
        <property type="gene ID" value="ANT_18390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18390"/>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008305_1_0_0"/>
    <dbReference type="OMA" id="WATERWI"/>
    <dbReference type="OrthoDB" id="1881002at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="696" mass="78558" checksum="6D45891B9AED3DF0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N646</accession>
    <name>E8N646_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosidase</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_18840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560287.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63910">
        <property type="protein sequence ID" value="BAJ63910"/>
        <property type="gene ID" value="ANT_18840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18840"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001528_3_1_0"/>
    <dbReference type="OMA" id="YKAGSGH"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="452" mass="51691" checksum="A753B0C1BF11D013" modified="2011-04-05" version="1">MGTEFSERYRPQFHFTARKGWLNDPNGLVYYGGLYHLFFQHNPYGNEWGNMTWGHAISTDLIHWKQMERALLPDELGTMFSGSAVVDWNNTAGFQTGESPAIVLIYTAAGGTSPESEGKPFTQCLAYSNDGGKTFTKYKDNPVLPEMAPENRDPKVIWYEPDKKWIMALYLQENDFALLASPNLKEWSHLQTLTLPGCIECPDFFEIPLENQPEISRWVFMAANGNYLLGKFDGNHFEAETPLLISDFGKNYYATQTFSDLPDQRRIQIAWMRGGIYPDMPFNQQMSFPCELKLRETPEGLRLTRHPVQEIETLWEQSIEKEPIFLDQDEHVFPISPAELLDLEMQLESGNSQEITIIVNAIAIRWNVQEHCLEVLDCSAPLPAEIQTLDIRILIDRTSLEIFALEGTRNFSCCTLECQAQPFILFKTAGKGAVLSRLKFRKLSSIYGLQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N650</accession>
    <name>E8N650_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63914">
        <property type="protein sequence ID" value="BAJ63914"/>
        <property type="gene ID" value="ANT_18880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18880"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_267531_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007892">
        <property type="entry name" value="CHASE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05228">
        <property type="entry name" value="CHASE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="415"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1232" mass="141615" checksum="73F6D9AC21C28598" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N668</accession>
    <name>E8N668_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="2">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">pcm</name>
        <name evidence="3" type="ordered locus">ANT_19060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560308.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63932">
        <property type="protein sequence ID" value="BAJ63932"/>
        <property type="gene ID" value="ANT_19060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19060"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_0"/>
    <dbReference type="OMA" id="TISAIHM"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="223" mass="24965" checksum="CC4277470D93D59E" modified="2011-04-05" version="1">MDTESSWFEARLRMVKEQIEQRGIRDPRVLQAMREVPRHLFVPEEEQPYAYEDCPLPIGFGQTISQPYMVAIMTALLELRGDEKVLEVGTGSGYQAAILSRIAREVHTIERHQALAQKAGERLQALGYTNVKVHVGDGSLGIPEEAPFQGIIVTAAAPKVPTPLLEQLSMNAYLVIPVGGPGGQELMRWQKTPAGFEPKELFPVAFVPLRGKEGWKEDQWYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8N682</accession>
    <name>E8N682_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19200"/>
    <dbReference type="EnsemblBacteria" id="BAJ63946">
        <property type="protein sequence ID" value="BAJ63946"/>
        <property type="gene ID" value="ANT_19200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19200"/>
    <dbReference type="HOGENOM" id="CLU_3076173_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="52" mass="5996" checksum="C4409EB2C37DFCDC" modified="2011-04-05" version="1">MQTQFGDSSFRFDWVISPSLIDQALKRFSLGMYSIHGPCLMIGQGYMRMECD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N696</accession>
    <name>E8N696_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560333.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63960">
        <property type="protein sequence ID" value="BAJ63960"/>
        <property type="gene ID" value="ANT_19340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19340"/>
    <dbReference type="HOGENOM" id="CLU_948792_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="32786" checksum="925507C5A7A9254E" modified="2011-04-05" version="1">MKPSARVWLILGLILSAVTFTALSVTLYLRPADLFSQRLVWALIGLGFSLLLMSVLAVELLRRKPAELQTFPPVWRIFLLIYVLTPVVLVFPVWIVAIGLGISQTLPTFFSPQQILALPAPWVWIIQGSLLFLFMLPQILPVRQWFSPISQPLLTLGASFLLGWMLALMSLFGYHLSARLLGVNPGVIPAPETIQKWVAGFLGVLILPISEQLFFRKYFFQALTLRLSPIQAGGASALLFALVQGRPLLFLPALIFSLLLQWLTRSSSDPRMALLTHAFANVFLMILNWNLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B6</accession>
    <name>E8N6B6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19540"/>
    <dbReference type="EnsemblBacteria" id="BAJ63980">
        <property type="protein sequence ID" value="BAJ63980"/>
        <property type="gene ID" value="ANT_19540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19540"/>
    <dbReference type="HOGENOM" id="CLU_703294_0_0_0"/>
    <dbReference type="OrthoDB" id="2146903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="392" mass="42595" checksum="768943E51B9B2CB7" modified="2011-04-05" version="1">MFALIGKDFSMSSGKKFIVLVLSALVLALAWMGGTWTTTQGATQGQSTLPTITPTREPPDTPTPTRVGAPPPTFPIPLIFIVSVVPGESVTIRTANFPPNTDFDVLMNYYGTLGIGGEKVATVNSGSGGVLTWTFNIPSFLKDAARIAIRLQSQRGYYSYNWFWNKPTSGTGQAPSKPFVIPTFKIIAVERDKTVTIQTANFPANDTFDVLMNYYGTLGIGGIKVDQVNSGSGGTLTFTFNIPEAMRGQTKIAIRLQSPTSGYYAYNWFWNNSTSEASIPPSTPPAESPVPSLPPGVIPTFRIQSVVRDTSVTIVTSNFPQNDTFDVLMNNYGTLGINEVKVETISSGSGGTLTLTFTIPESMRGKSRIAIRLQSSKSGYYAYNWFWNNTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D9</accession>
    <name>E8N6D9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560376.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19770"/>
    <dbReference type="EnsemblBacteria" id="BAJ64003">
        <property type="protein sequence ID" value="BAJ64003"/>
        <property type="gene ID" value="ANT_19770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19770"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077889_0_0_0"/>
    <dbReference type="OMA" id="QFTYKPT"/>
    <dbReference type="OrthoDB" id="1160025at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029059">
        <property type="entry name" value="AB_hydrolase_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12695">
        <property type="entry name" value="Abhydrolase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_5" evidence="1">
        <location>
            <begin position="67"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="27102" checksum="3AE2E3BB4A87FFE8" modified="2011-04-05" version="1">MKRWRILWIVFALLILLAGGFVVWGSMPAQPMPEALVALQSDEWVEVSDSRWLVFTPRSQTPDTAWIFYPGGRVDPRSYAPLARRVAEQGFLVVVPSMPLNLAVFAPETALDILQEYPAIKTWVIGGHSLGGAMAANFVKKHPGKIQGLILLASYPAEGDSLRDVSSLKVLSIYASLDGLATPEKVLSSRPLLPEDTTWVEISGGNHAQFGWYGVQSGDLPARISREQQQSQVVSAILEFLQYLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK2</accession>
    <name>E8MXK2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 7" type="primary">sucD</name>
        <name evidence="7" type="ordered locus">ANT_20570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560453.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64083">
        <property type="protein sequence ID" value="BAJ64083"/>
        <property type="gene ID" value="ANT_20570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20570"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_0"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="287" mass="29859" checksum="A690FE12BA01D6F4" modified="2011-04-05" version="1">MSILVNKQTRLVVQGITGNEGLFHTTQMVAYGTNVVAGVTPGKGGEWVLEGKIPVFDTVRSAVETTGANTSVIFVPARFAPDAILEAADAGVSLIVCITEGIPVQDMMRVRSYLDQKKVRLVGPNCPGILTPGEAKVGIIPNNISIPGNIGIVSRSGTLTYEVLYALKMAGKGASTCVGIGGDPINGTNFVDVLDMFEADPHTDQVVMIGEIGGTDEEKAAEFIARNMTKPVVAFIAGQSAPPGKRMGHAGAIIEGGTGTARDKVLALEKSGVRVANHPEEIPGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN2</accession>
    <name>E8MXN2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560483.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20870"/>
    <dbReference type="EnsemblBacteria" id="BAJ64113">
        <property type="protein sequence ID" value="BAJ64113"/>
        <property type="gene ID" value="ANT_20870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20870"/>
    <dbReference type="HOGENOM" id="CLU_2192145_0_0_0"/>
    <dbReference type="OrthoDB" id="2086679at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="109" mass="12403" checksum="95A1FD10090DAE02" modified="2011-04-05" version="1">MKTPAGKECPYFYGNYFRGRKQEECRLIGNQPSPYHWGSDLCKTCSVPEIVLANACPHMQLQAKVQSFLFGLIRRVKVLAYCEKSHSIVEEPQIGCGQCHPFPPFIPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS2</accession>
    <name>E8MXS2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21270"/>
    <dbReference type="EnsemblBacteria" id="BAJ64153">
        <property type="protein sequence ID" value="BAJ64153"/>
        <property type="gene ID" value="ANT_21270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21270"/>
    <dbReference type="HOGENOM" id="CLU_1458440_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="185" mass="20590" checksum="023FE7EC578A1973" modified="2011-04-05" version="1">MLEECLMWNRVIIIGNNLRDHGREGIIKNKENQGTDTLLPEAMATRQSLSRESGEVLAFCFWLGRVPGFDRLTPHAVQVRTGQFRTVDTSPVRTWNINKGKWALTALESPPAVRGTAAGGSRERRCTMNPNLIIALTFLMLVLIPLLFTLFLIVVQAVIVLALSQSNEERKAALVSVLVGALKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY17</accession>
    <name>E8MY17_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_22220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64248">
        <property type="protein sequence ID" value="BAJ64248"/>
        <property type="gene ID" value="ANT_22220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22220"/>
    <dbReference type="eggNOG" id="COG2940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133663_0_0_0"/>
    <dbReference type="OMA" id="NIVAKRD"/>
    <dbReference type="OrthoDB" id="1675945at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="5">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="20269" checksum="8FF07229344D7999" modified="2011-04-05" version="1">MKNGETMKQPERYSYLSPKVEARRCPDKGGYGVFAREKIHAGELITVWGGRVVTEEELDEVPIEQATHGIQVDEGIYLIPLGIDEPADMFNHSCNPNAGLFGQIALVAMRDIEPDEEVCFDYAMSDSSPYDEFECHCGEPTCRGKVTGNDWQLPELQARYEGYFSPYLQRRIQKMHSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY37</accession>
    <name>E8MY37_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssb</name>
        <name evidence="5" type="ordered locus">ANT_22420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560636.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64268">
        <property type="protein sequence ID" value="BAJ64268"/>
        <property type="gene ID" value="ANT_22420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22420"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_0_2_0"/>
    <dbReference type="OMA" id="GQMQERT"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="15380" checksum="904F518AAF74D71E" modified="2011-04-05" version="1">MSRGLNKVMIIGHLGRDPEMRYTPSGKPVTTFPVATSRTWNSVDGERHTETEWFNVVAWGQLAEICKQYLAKGQQVYVEGRLQTRRWEDSEGVKHVTVEIVASEMMMLGDRRDVNQAVETALSEEEETDEEYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY86</accession>
    <name>E8MY86_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PQQ_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560684.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22910"/>
    <dbReference type="EnsemblBacteria" id="BAJ64317">
        <property type="protein sequence ID" value="BAJ64317"/>
        <property type="gene ID" value="ANT_22910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22910"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745401_0_0_0"/>
    <dbReference type="OMA" id="GRVLWQR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228468" description="PQQ_3 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="PQQ_3" evidence="2">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="350" mass="37883" checksum="31987233A86BFC6B" modified="2011-04-05" version="1">MKKLKIVLWLGLAMVFLAACAGVPLNNWPGLAATEDMVVLAYGQVHVVDARTGVEKWKYPEKIDNASLIFSNPAVVDNKIIVASYANVVQALDAQSGAVLWTFDTFKGKGKFVAGPVIAGDTILVPSTDHHLYALDLNGKLLWRFQSRNALWAPVVADEEHVYLAGLDHYLYAIRLSNGQMDWEVDLGGPLIHAPGSDGNGRLYMTTLKREALAIDKQDGRILWRTPLTGSSWAAPLVAEGKVVFGTDQKKAYILNAENGQVLASLDVAAGIIGGPALFEGVPVLVTEGGEVFQFKWDGTRGWTRTIEGQLGTTPVISDGRLVVSGLQMKNLIVTFRPDGTEDWSLAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB9</accession>
    <name>E8MYB9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558462.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00300"/>
    <dbReference type="EnsemblBacteria" id="BAJ62064">
        <property type="protein sequence ID" value="BAJ62064"/>
        <property type="gene ID" value="ANT_00300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00300"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_35_0_0"/>
    <dbReference type="OMA" id="PAVRHGC"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="219"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="395" mass="43870" checksum="EB6021867B63070A" modified="2011-04-05" version="1">MRLLLIHNDYQQLGGETLAFDAELSLLRQAGHEVILYRRSNEELRHASALQKFLLGLSVLHSPRAVREVRQLIRTHRPEVAHVHNVFPLISPAVYRLLADEGVPVVQTLHNVRFLCPNGLFYTQGRLCERCKKGNTLHAVRWRCYRNSYPASALYALAIGWHRRRGTFARITRAIALTPFTVQKMVESGLFRAGQMEVLGNFIPDPLPEARSAPPVNGYVAFLGRLSEEKGAHLLIEAARHLPGVTFRLAGEGGQRASLEQRARGLSNVEFVGQIPPEQRWDFLRGAALAVVPSTVYEQFSLAALEAMACGVPVIAARIGGLPYLVEDGVQGRLFTPGNVEELVERIRGLLADPAQAHALGQAGRRTVEERFTSARHLEGLMSIYRKAIHGETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD2</accession>
    <name>E8MYD2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_00430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558475.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00430"/>
    <dbReference type="REBASE" id="32146">
        <property type="entry name" value="M.AthUNI1ORF430P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62077">
        <property type="protein sequence ID" value="BAJ62077"/>
        <property type="gene ID" value="ANT_00430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00430"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_2_0"/>
    <dbReference type="OMA" id="MIEMWDD"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="278" mass="32095" checksum="C04A02E17B12F381" modified="2011-04-05" version="1">MSTNHKLIIGSSVNMPEIPDESVHLVVTSPPYFNAPFDYKGLYSSYQNYLEMLKQVAREAYRVLANGRIFVLNIDDMLVDGEKFPIVADATRIFLDAGFRYRDRIIWKKPEGYLRISRRSGVLLQNPYPMYFYPDNLLESIIIFQKGRFDYKSVPQDVREASKINIKEFQENKWYMTLWEMVNVLPNSPLEKDIAAFPEELPYRCIQLFSYVGETVLDPFCGSGTTMKVARQLGRNSIGIEINEALIPIITTKVGFGNQHGLFNGEDTFECLIRQEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF7</accession>
    <name>E8MYF7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558500.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00680"/>
    <dbReference type="EnsemblBacteria" id="BAJ62102">
        <property type="protein sequence ID" value="BAJ62102"/>
        <property type="gene ID" value="ANT_00680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00680"/>
    <dbReference type="eggNOG" id="COG4481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180138_1_0_0"/>
    <dbReference type="OMA" id="RIKCLGC"/>
    <dbReference type="OrthoDB" id="2041238at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009296">
        <property type="entry name" value="DUF951"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38455">
        <property type="entry name" value="PTHR38455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06107">
        <property type="entry name" value="DUF951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="73" mass="8385" checksum="6D0AE93CD6BC5EB1" modified="2011-04-05" version="1">MKRMLPDIQLNDIVTLRKPHPCGGYEWKVVRLGADIGLECLTCGRVILLSRRELSRRMKKIRSGESHDSTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYG3</accession>
    <name>E8MYG3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558506.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00740"/>
    <dbReference type="EnsemblBacteria" id="BAJ62108">
        <property type="protein sequence ID" value="BAJ62108"/>
        <property type="gene ID" value="ANT_00740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00740"/>
    <dbReference type="HOGENOM" id="CLU_640375_0_0_0"/>
    <dbReference type="OrthoDB" id="2156108at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="49042" checksum="3886A17EF446DDF0" modified="2011-04-05" version="1">MTPGPKRTGWWLFLIALLYFIALIFPNARGAQSERMLLVTSLDEPVTYQYVVRMLTPASDFKDLFSRWVLYGDYHYGYPFYFFSALAVLPVRLIYGAEFTNYTALNLLLLRQAISVLPMLLAILLLVYEQTRFRTLWQSLALTAVMFLVPAFVRNHLQWWHPDALSVLAVTLVLVFLRRDDLRFGRFFWLAAAACGVAVGIKFAGVFFFLTIPIYLFMGYRQKRLTLPQVFTKGALFVVVALLALVLSNPFLYNEGARQELMRIQTEKVEVLGSGYEDASPYYQKGPAFWKWTLSTWYGHPLFLAFLGLSLLVGCLRGPNQRFNGLILTYILPQAVYLLWFVSVKPDHYWLPVMVPLFSTALTLPTALVEGWFPAVSRRAWLRRGLLALLVAVLMAQSAVFLLRPYSGVIAQVQNAMHIEEIYYDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYG5</accession>
    <name>E8MYG5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_00760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00760"/>
    <dbReference type="EnsemblBacteria" id="BAJ62110">
        <property type="protein sequence ID" value="BAJ62110"/>
        <property type="gene ID" value="ANT_00760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00760"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="MQISARR"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="122"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="185" mass="21139" checksum="3FC85C65151EDCD9" modified="2011-04-05" version="1">MNDMEEAALLEKARAFDLDALAEVYDRYSPPLYLYALRLLGDEALAEECVADTFHRFLQALRHGGGPQSHLQAYLYRMAHNWITDIFRRNPARWQELAEDETTPEQANSPSLEAQADLLLERERVRRALMALTPDQRQVVVLKFLEGWDNEAIARAVGKPVGAVKSLQHRALASLRRWLGKEEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ36</accession>
    <name>E8MZ36_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pribosyltran domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558577.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62179">
        <property type="protein sequence ID" value="BAJ62179"/>
        <property type="gene ID" value="ANT_01450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01450"/>
    <dbReference type="eggNOG" id="COG2236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_1_2_0"/>
    <dbReference type="OMA" id="TAAVMFY"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="169" mass="19321" checksum="5CE4F0D6DC0C94E7" modified="2011-04-05" version="1">MRREILTWNDVDQLIDHLIPQFEVEFDALVLITHGGLIPGGMLAEALKVNDIFIAAVDFPNELEAEKQRERARLLAWPKFLQFPDESLLRGRRILVVDDVWGSGRTMTAVKNRVTASGGIAYTCVLHFNPYRSLFGTLRPDYYAAITDAYIVYPWEIKRGPEAVLLRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ93</accession>
    <name>E8MZ93_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoadipate:succinyl-CoA transferase, B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">catI</name>
        <name evidence="1" type="ordered locus">ANT_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558634.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02020"/>
    <dbReference type="EnsemblBacteria" id="BAJ62236">
        <property type="protein sequence ID" value="BAJ62236"/>
        <property type="gene ID" value="ANT_02020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02020"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049557_0_0_0"/>
    <dbReference type="OMA" id="YDPWFAK"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="300" mass="33845" checksum="1A41C7E378CC077B" modified="2011-04-05" version="1">MSKLCTLSDAVSRLIHNGDTVYLAGFTHLIPFAVGHEIIRQGKKNLTLARATPDLIYDQMAAAGCARKIIFSYMGNPGVGSLKVLRRMLEAGQLEWEEYSHFGMITRLQAGAAGLPFLPMNLTAAPDLERVNPNYKRLTDPYTGREVMALPPLNPDVAVVHVQRADEHGNAQIWGILGEQKEAAFAAERVIVTAEEIVPEEVIRSDPNRTIIPEFIVDAVCHVPYCAHPSYTQGYYDRDNAFYLEWDRISESDEAVQDYLKEWVYGVRDRAEYWEKLGEETHRRLAVSPRYAAPVNYGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA9</accession>
    <name>E8MZA9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_02180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558650.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62252">
        <property type="protein sequence ID" value="BAJ62252"/>
        <property type="gene ID" value="ANT_02180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02180"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="HGTIFYR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="223" mass="24808" checksum="BBE307A4B62FE318" modified="2011-04-05" version="1">MKTLLEAHNLSKLYGNGRSQVVALKDVSISLFPGECLALMGPSGSGKSTLLSILGLIIRPTSGCVLVQGKPVEEDERSRARLRNEFFGYIHQEFAVIENETVEKNVMIPLQYARIKPSRQERQSRILQLLKQLNLDWAVHKNVSFLSGGERQRVAIARAIINHPSVILADEPTAALDRKSAEEIMGFVLSMRDQGCSVLIATHDERIAKTCDRVLHLVDGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK2</accession>
    <name>E8MZK2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560905.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64550">
        <property type="protein sequence ID" value="BAJ64550"/>
        <property type="gene ID" value="ANT_25240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25240"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_851640_0_0_0"/>
    <dbReference type="OMA" id="VNERAPF"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="73"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="34340" checksum="99CDCFC4579CDFD8" modified="2011-04-05" version="1">MRTWRQWILGSLLIFFIGWAMGCTAPPTPAGENFPTFTPAGTLVLYRTRTPSPTPQASPTLTLPLPSPTPTPIRHVVKKGEDMFGIALRYGIAPQALLEANPTVNPRVMSVGTVLIIPAAGLPTPTGQVPSPTPQPLVLGEPVCHPALDGGAWCFVVVQNPLEQALEDVVAVIRVSGNAQGELLERTAYAPLNLLPAGKRLVLSAYFPAPFPESPQVAAELRMAHPVPAEDVRYLPAAVEVEQVQIASDGKSAVIGGNIILGESSVTAQVLWLALQAFDGAGKPVGVRRVDMPAPAQGDQSVPFKATVYSAGAPISSVEVLVEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN4</accession>
    <name>E8MZN4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64582">
        <property type="protein sequence ID" value="BAJ64582"/>
        <property type="gene ID" value="ANT_25560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25560"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_3_2_0"/>
    <dbReference type="OMA" id="APIKVYM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04623">
        <property type="entry name" value="CBS_pair_bac_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044725">
        <property type="entry name" value="CBSX3_CBS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="10"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="77"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="140" mass="15883" checksum="17E77F4F78C4439D" modified="2011-04-05" version="1">MIQTVRHILEVKGSDVWSIGPDATVFDALRMMADKDVGALVVMENDKVVGIISERDYARKIILHGKSSKETLVREIMSTNLYTVHPDQTVEEAMEIMTNKRVRHLPVMEGETLLGMISIGDVVKNIIYRQREIIKSMSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N012</accession>
    <name>E8N012_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_03130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558744.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62347">
        <property type="protein sequence ID" value="BAJ62347"/>
        <property type="gene ID" value="ANT_03130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03130"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_0"/>
    <dbReference type="OMA" id="APYWTTY"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="30"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="385" mass="42596" checksum="AA37E3C5F2440D68" modified="2011-04-05" version="1">MRETFLNHRIRGLRPSAIRKFFDIAATMQDVISLGIGEPDFDTPAPIVQAGIRSLQAGYTHYTSNSGVMELRQALAEHLERLYGVHYDPTEIIITVGGSEALYLAASATLDPGDEVIIPTPCFVSYQAQVHMAGGVPVEVPCRMENNFEVDPQDVAAAITPRTKAILLGFPSNPTGAIARRETLLEIARLAEEHDLLVMSDEIYDRLVYDGQHVCFPSLPGMWKRTILLGGFSKDYAMTGWRIGYAAAPHAILQGLLRLHQYTVMCASTTAQMAAIEALRNGEEYVQQMVAEYDRRRRLIVKGLNEIGLPTFEPKGAFYAFPKVSVTGLDDETFASRLLTEERVAVIPGSGFGAGGEGHVRISYATAYEKLEEALRRMERFVNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N017</accession>
    <name>E8N017_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">gatC</name>
        <name evidence="2" type="ordered locus">ANT_03180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558749.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62352">
        <property type="protein sequence ID" value="BAJ62352"/>
        <property type="gene ID" value="ANT_03180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03180"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_1_2_0"/>
    <dbReference type="OMA" id="VTPMAMK"/>
    <dbReference type="OrthoDB" id="1780195at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="96" mass="10754" checksum="B9F36FC6DA790A53" modified="2011-04-05" version="1">MSLTLAEVEHIARLAHLELTEEEKNRFREQLSAILEYAARLQEVDTRSISPTAWTFNAQAPLREDVPAQGLSTAEVLSNAPQVQNDQFRVPPVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N032</accession>
    <name>E8N032_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_03330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558764.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62367">
        <property type="protein sequence ID" value="BAJ62367"/>
        <property type="gene ID" value="ANT_03330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03330"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_7_0_0"/>
    <dbReference type="OMA" id="KSWDFHV"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="533" mass="57892" checksum="E51B71A77E386573" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N056</accession>
    <name>E8N056_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative D-aminopeptidase</fullName>
            <ecNumber evidence="1">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dppA</name>
        <name evidence="1" type="ordered locus">ANT_03570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.11.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558788.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03570"/>
    <dbReference type="EnsemblBacteria" id="BAJ62391">
        <property type="protein sequence ID" value="BAJ62391"/>
        <property type="gene ID" value="ANT_03570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03570"/>
    <dbReference type="eggNOG" id="COG2362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086038_1_0_0"/>
    <dbReference type="OMA" id="ATGVTWP"/>
    <dbReference type="OrthoDB" id="1439650at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="273" mass="29555" checksum="DB9E4B601FA6C448" modified="2011-04-05" version="1">MKLYVVCDLEGVAGVVNHLQQCRWNAEKGWYAPFLEQARRLATLELNALVEGALSAGAEEVIAWDGHGNFPGGLDYELLHPACKLILDAGDGGPAGLDGSFDALLQLGLHAMAGTPRTVLAHSFYSHLLEYTVNDEAVGEIWMNAYTAGKAGVPFIFLSGDRAAALEAQRLVPEMEVAVVKEGLSDRPLGLNHPQPALCLSPQAARKTIRKAVAKALWKVGKIAPFTRKPPFTLRARFSEECFAEERASLPGARRVDAFTVELAGAEEPWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N065</accession>
    <name>E8N065_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoglucanase C</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_03660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558797.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03660"/>
    <dbReference type="EnsemblBacteria" id="BAJ62400">
        <property type="protein sequence ID" value="BAJ62400"/>
        <property type="gene ID" value="ANT_03660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03660"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018668_1_0_0"/>
    <dbReference type="OMA" id="SIEKRIF"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="346" mass="41042" checksum="642774811CC78CF8" modified="2011-04-05" version="1">METLSGFQAGVNLGGWISQYGSFDYQHFETFIQEEDIARIASWGMDHIRLPMDYPIFESDDNPFSYNERGFGYVDRTIEWCEKYNLNLILDLHRAPGFSFNTLEENRLFQNVDLQERFLALWETFARRYRKVERPTLIFELMNEVVLPTSAPWNELAQRAVRRIRSVDAERWIMIGGNHYNSAWTLKDLVRVDDPHIVYTFHFYEPMPFTHQKAYWVDFLKAFDTTTPYPGEIPHLEEFLAQHPEYAEQFAAYRGKVMNLDMLRYFIQPAVDFLEQTHLPLYCGEYGAIDHAPLESRLNWHRDIVGLLRQHGIGRAVWSYKEMDFRLVNWKGEVESQELVEIVSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N068</accession>
    <name>E8N068_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558800.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03690"/>
    <dbReference type="EnsemblBacteria" id="BAJ62403">
        <property type="protein sequence ID" value="BAJ62403"/>
        <property type="gene ID" value="ANT_03690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03690"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692109_0_0_0"/>
    <dbReference type="OMA" id="LENIDCE"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="209"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="404" mass="44934" checksum="2E77C421615ED6B8" modified="2011-04-05" version="1">MNIEDARRYLKMLCEDIPDRSVGSEGNRRAVAFFTELVSSFGWQTETMALPVIDWQERGADLRIGEQSFDVRVSPYSLGCAVEAPLISAETLKELERLEVEGRVLLLHGELTREKLMPKNFPFYNPEEHQRILALLGQKQPAALICATGRNAAVAGGVYPFPLIEDGDFDIPSVFTTEEAGQVLLSCVGKTVWLESRSNRIPAFADQVIARKGNNPDRRVVVSAHIDAKKGSPGTIDNAIGVVVLLFLAELLKEYHGDPGIELVPFNGEDYYAATGQMEYLRKNQGRFHTIWLNINLDGVGYKDGKTALSFFNLPESVKMHMDEILARYEGLVEGFPWVQGDHSIFIQQGCPAVAVISQWLLEHLDSQEITHTSKDAPSIVDPHKLVEIAVALKDFLNSLSELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N080</accession>
    <name>E8N080_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_03810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558812.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03810"/>
    <dbReference type="EnsemblBacteria" id="BAJ62415">
        <property type="protein sequence ID" value="BAJ62415"/>
        <property type="gene ID" value="ANT_03810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03810"/>
    <dbReference type="eggNOG" id="COG3583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596714_0_0_0"/>
    <dbReference type="OMA" id="TIYTHRA"/>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="2">
        <location>
            <begin position="257"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="458" mass="49817" checksum="B2139E05D20614D7" modified="2011-04-05" version="1">MRNLFRWLPALLVFAGITLLGVYFAQPVYIRVDGQTLTTHPLALTVKGTLRQTGVEISTEDLVIPPDNHLIPANGIIEVHRAVPVHLLVDGQPFSFLSVARAPAALAHQAGFLLFPGDVVLHNGAPVNPIQPIGGDAPIYLQIKRARPVRLVEDGGEKTLFAIGNTLRQALWQAGVPLLPGDVLSPSPDTPLSTASKAALRRARPITIEVDGKDIQTFSAAPTVGAALAEAGLSLQGLDRAEPDENSPLPADGRIRVVRVREEIVLQQKTLPFSSTLQPDSSLPLDERRVIQPGKYGVRVSRERVRYEDGVEIARFTEGEWTAAEPVNQVVGYGTQVRVQTAQTPDGTIEYYRKVTVYATSYSPCQQGLGRCSWSTSSGMRLQKGVVAVTLSWYRLFKGARVYIPGYGFGVIGDVGGGIPGTYWVDLGYSEEDYVRWSQNVEMYFLTPAPPNPPAILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0A1</accession>
    <name>E8N0A1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xseB</name>
        <name evidence="5" type="ordered locus">ANT_26240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561004.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64650">
        <property type="protein sequence ID" value="BAJ64650"/>
        <property type="gene ID" value="ANT_26240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26240"/>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145918_0_3_0"/>
    <dbReference type="OMA" id="RICESHI"/>
    <dbReference type="OrthoDB" id="2057189at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="74" mass="8234" checksum="A7D247AC013BB804" modified="2011-04-05" version="1">MMDSLSEIANLSYEDAVRELEAILEKLETAQPSLEETLRLYERGQALAKHCAALLEQAELRIQTLNGNDLSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B1</accession>
    <name>E8N0B1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561014.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26340"/>
    <dbReference type="EnsemblBacteria" id="BAJ64660">
        <property type="protein sequence ID" value="BAJ64660"/>
        <property type="gene ID" value="ANT_26340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26340"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OMA" id="WEKFWKI"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="32975" checksum="4EC284A5E3F52F7D" modified="2011-04-05" version="1">MNVQKLLRGEMKHRTREALHGYAFVFIWIVGFLVFTLAPMVETLRYSMNEVTVTATGIVMDFREWQNYTRALFTDPNFVELLIEYVIKTLVSVPVVLIFSMIIALLLNLRFKLRGVFRTIFFLPVVITSGPVIKELAAQGAASAPQVASSAAVMQFLQGLPTYLRNPVEYLLTSFILILWFSGVQILIYLAGFQKIDHSIYEAAAIDGASAWESFWKITLPALTPTTIVNAVYTIITLSHFSENEVIRYIYSRTYDVQGGIGYASAMSYIFFLALVLLLAVVYGGLTFGTKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0C8</accession>
    <name>E8N0C8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561031.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26510"/>
    <dbReference type="EnsemblBacteria" id="BAJ64677">
        <property type="protein sequence ID" value="BAJ64677"/>
        <property type="gene ID" value="ANT_26510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26510"/>
    <dbReference type="eggNOG" id="ENOG5030TAR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_856978_0_0_0"/>
    <dbReference type="OrthoDB" id="1657827at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="324" mass="35510" checksum="2FB4485C32E9D87F" modified="2011-04-05" version="1">MVDMTVAVSESAFQRLFVVLRDSIRWEAQDSTNFGPFTAGYHVKGHLEGGSVEFRPDHSVLIDELDVRWDKFEFTLGLDIPEICVGGGCVDMPWPIPDFCLPRWCVFSANPDASISPDLAAFVAQELSLAGRPVVRYYDASVPSPAIDPCGLLRDLLVDASVIDPFPDHNQWHIHLNPDFIDLDLFDFADVVGDLIENALTSAVTALLPGGWVRDLILAIIGGIADFIRWLLDIPDEIDEWLSDLFNISFGLGDLLIQLVGEFFGACVPILRVDDPLEILAKETSTSVLLSGAPVQLVPVTVPVRNLSVQVEDVEMVIQADVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0D4</accession>
    <name>E8N0D4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_26570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561036.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64683">
        <property type="protein sequence ID" value="BAJ64683"/>
        <property type="gene ID" value="ANT_26570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26570"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_0"/>
    <dbReference type="OMA" id="RTSWLIV"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="161"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="42119" checksum="B7C91BED3ABE745F" modified="2011-04-05" version="1">MLTLFRRHLAWKLFLSYVIVVLVGVVVLATATSFSVPAAFERHMAGMSAMMPGMMGNSHSMEMELFANYRASVTEALSLAVITALIAAVVASYFISRQVVNPIRTMMNLSHRIAEGEYKERLTISGDLSQLDELDQLALSFNQMADKLEKTETMRRQLIGDVAHELRTPLAAIKGYIEGLMDGVIPAEGNTYQQIHDEINRLQRLVDDLQELSRVESGAFHLKPELVSLSDLMDTIQNIFVPQFIHKGIQFQIQIEPNLPPVLIDKDRILQVLTNLVGNALQYTPSGGKVTVQISKQRTEILISVSDTGIGISPEHLPFIFNRFYRTDKSRARASGGSGIGLTIAQALVKAHHGRIWAESGGEGKGSTFYFTLPIPKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H8</accession>
    <name>E8N0H8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_27010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561079.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27010"/>
    <dbReference type="EnsemblBacteria" id="BAJ64727">
        <property type="protein sequence ID" value="BAJ64727"/>
        <property type="gene ID" value="ANT_27010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27010"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_1_0"/>
    <dbReference type="OMA" id="YYRCEIS"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045045">
        <property type="entry name" value="RTM2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="PTHR43670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="146" mass="16825" checksum="6E587AD74D5725FB" modified="2011-04-05" version="1">MIYRRYTMPSIWEEMNRMQREMERLMQAFLPETGRVSTVFPAINAWTNDEAEIVTVEVPGVDPKDLDISVVNDVLTISGERKPEDPKDDIRYHRRERVCGKFSRSIQLAFPVNTDKVTASYENGILKIVLPRAEADKPRKITVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L7</accession>
    <name>E8N0L7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561114.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64766">
        <property type="protein sequence ID" value="BAJ64766"/>
        <property type="gene ID" value="ANT_27400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27400"/>
    <dbReference type="HOGENOM" id="CLU_2784825_0_0_0"/>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="68" mass="7673" checksum="73B51BCC099E77FD" modified="2011-04-05" version="1">MCLALIGLFPGGDMKGLVALALFDSRLYLLAWLGAGVVYLLWRILRRERRMPGYVGFVVGAVGWWMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S6</accession>
    <name>E8N0S6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gyrB</name>
        <name evidence="12" type="ordered locus">ANT_04370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558867.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04370"/>
    <dbReference type="EnsemblBacteria" id="BAJ62471">
        <property type="protein sequence ID" value="BAJ62471"/>
        <property type="gene ID" value="ANT_04370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04370"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_0"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="422"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="639" mass="71129" checksum="8023F2FE7870D8B9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T8</accession>
    <name>E8N0T8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2-oxoglutarate ferredoxin oxidoreductase delta subunit</fullName>
            <ecNumber evidence="5">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_04490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04490"/>
    <dbReference type="EnsemblBacteria" id="BAJ62483">
        <property type="protein sequence ID" value="BAJ62483"/>
        <property type="gene ID" value="ANT_04490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04490"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_5_3_0"/>
    <dbReference type="OMA" id="CARMCPD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="81" mass="8485" checksum="CB2B9EEBC5CAD55B" modified="2011-04-05" version="1">MPVQGRIVVSDLYCKGCELCVAACPQHVLRLSPDRLTAKGYHPAELAGPGCTGCGICAVVCPEAAITVYRQKAPARKTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W7</accession>
    <name>E8N0W7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558908.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04780"/>
    <dbReference type="EnsemblBacteria" id="BAJ62512">
        <property type="protein sequence ID" value="BAJ62512"/>
        <property type="gene ID" value="ANT_04780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04780"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_0"/>
    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="20031" checksum="2218CB89C5019C06" modified="2011-04-05" version="1">MAFERLNRTILHTGRVFTVAQHTLRLPNGKSQTYDLVEHEGAVTILPLDEAGNIWFVRQYRLGAERSLLELPAGVLHAGEDPLEGAAREVREEIGMAARTLKRLGGFFMAPGYSTEYMHVFLATGLTPAPLPQDEDEFIERVSLPFQEALAMAQRGELEDGKTLVALFLALPELTGEHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N106</accession>
    <name>E8N106_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative M20 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62551">
        <property type="protein sequence ID" value="BAJ62551"/>
        <property type="gene ID" value="ANT_05170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05170"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_1_0"/>
    <dbReference type="OMA" id="NYGDHSG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="235"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="486" mass="52985" checksum="CE1C91A66A9CC1B4" modified="2011-04-05" version="1">MGILVLVLVLFFLAFLLIRTVLFGKVPPPVEQAELPEVDGNIVAEHLAAVLRHRTISESEGKPADPQTFYALHRELERLYPRVHATLRVDVVNRLSLLYTWKGRDEFLEPVLLAGHLDVVPVDPETRDAWKFPAFDGHIEDGAVWGRGALDTKNSVVAILEAVETLLKQGYQPKRTILLAFGHDEEIGGFQGAAQIAGRIQAYNARLAAVLDEGGAILSGGVVPGVSLPVALIGIAEKGYATLQLTVESSGGHSAMPPKHTGIGVLARAITRLENAPLPERLHMVHRMFEHLAPFLPFGLRLAFANLWLFRPLIARVLSANPRTNALIRTTTAVTMVQGGVKDNVLPARATAVVNFRLMPGDRVADVVAYARRVIADDAVQISLPQGGSWEASGVSPTDSPAYLGILQALGQVYPEAVSAPYLVAGATDARHYQAVCDQIYRLSPMLITPEELKTIHSENEHISIETLARMVQFYIQLIKIWGENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N139</accession>
    <name>E8N139_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561130.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64782">
        <property type="protein sequence ID" value="BAJ64782"/>
        <property type="gene ID" value="ANT_27560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27560"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1552108_0_0_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="172" mass="18829" checksum="02D11E4B2A0E4631" modified="2011-04-05" version="1">MPCLPVGGYSWETEWILPFLALSLRPMVQIARVTGGLLSDELGARYVTAALFADGKLLWRVNLQQSKSKALSGAVIASDGTACYPISASLLAVDAQGGLRWRINLPTYSIINPLPRLSRDERFLFFQEFVIDAQTGEMLFSQTPGPMDFYFVGADGRIYLYSSEGILAVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E4</accession>
    <name>E8N1E4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_28610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561232.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64887">
        <property type="protein sequence ID" value="BAJ64887"/>
        <property type="gene ID" value="ANT_28610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28610"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="ADPFYGP"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="341" mass="37461" checksum="500CC35F19C8C4B2" modified="2011-04-05" version="1">MTDKNLKITIKDVAAEAGVSFGTVSRVINNDIHVKPETRERVLKAMERLGFVANRQARSLAGGKTHFIGLLVPDLGTGYIGEIIRGIDAELTLQGLDLVLYTTHRTASKEAAYVANLAKGMVDGLLLVLPRNPADYIGVLTQRKFPFVLIDHQGTGKDCPAVGATNWQGGYDATEYLIKLGHRRIGFITGWMDLGCAQDRLAGYRAALRTYHIPEDPDLIYEGTFFQPDGYTGAMKFLDLPDPPTAIFASNDVMAMGVMDAVRMRGLRVPEDVSVLGFDDIPQASLVRPALTTVQQPLENMGRVAAQMLLDLIDQPERKVGRIELSTKLVIRESCQPPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H2</accession>
    <name>E8N1H2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-ribose pyranase</fullName>
            <ecNumber evidence="2 5">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rbsD</name>
        <name evidence="6" type="ordered locus">ANT_05430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RbsD / FucU family. RbsD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558973.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05430"/>
    <dbReference type="EnsemblBacteria" id="BAJ62577">
        <property type="protein sequence ID" value="BAJ62577"/>
        <property type="gene ID" value="ANT_05430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05430"/>
    <dbReference type="eggNOG" id="COG1869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135498_0_0_0"/>
    <dbReference type="OMA" id="IIRTGEC"/>
    <dbReference type="OrthoDB" id="1750843at2"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01661">
        <property type="entry name" value="D_rib_pyranase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023064">
        <property type="entry name" value="D-ribose_pyranase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37831">
        <property type="entry name" value="PTHR37831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="131" mass="14325" checksum="1DC3CF8B34EEA652" modified="2011-04-05" version="1">MKKTALLNSALSEVIATLGHGDMLVIGDAGLPIPAETYRIDLALTRNMPPFLDTVRAVLSEMQVEKVIVAKETGEVSPQVLAELKRLLPDTPFIEVSHEELKRLTRDARAVVRTGEFTPYANVILVSGVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I1</accession>
    <name>E8N1I1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aminopeptidase</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_05520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558982.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62586">
        <property type="protein sequence ID" value="BAJ62586"/>
        <property type="gene ID" value="ANT_05520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05520"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_0"/>
    <dbReference type="OMA" id="EITHDAM"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="354" mass="38828" checksum="E3BF3BBF87AFDEBC" modified="2011-04-05" version="1">MTDIKDFLKELISLPGLSGYEAPAREVISREWQTLVDELSVSPLGSLHALKRGSSPEPRPRILLAAHMDAIGMMVTRITPEGFLGFTEVGGLDPRILPAQPVRVYGKEPLRGVIVQPSDRLLPPSQKGKPVEMKHLLIDTGLPAEEVRRLVKVGDPIAFDTEPLELPEDLICGHTLDNRASVAALTVCLQTLQRAAHDWDVYAVATAQEEETLGGGFTSPFEIRPTLAIAIDVTFAKGPGVNDYRGKTLGGGVVLGWGPQSHPRVFDDLKALAERLDIPFEIEVYPRASGTDAYAMQIVAEGIPTMVVSIPLRYMHTPVEVVSLSDIRRVGRLLAEYILRLTPEDVKKIQWEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K6</accession>
    <name>E8N1K6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase FAD-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559006.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05770"/>
    <dbReference type="EnsemblBacteria" id="BAJ62611">
        <property type="protein sequence ID" value="BAJ62611"/>
        <property type="gene ID" value="ANT_05770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05770"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_0_1_0"/>
    <dbReference type="OMA" id="EIRGWQY"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="299" mass="32137" checksum="D28065CDE7D6465D" modified="2011-04-05" version="1">MQNPHPGLPEIEYIKPASLEEASKFLAAHAGEARPFLGGTDTFVRMRDGVWKDKYLVDVKGLDGTAQVSFDPEKGLTIGAGVPMNRVEAMPEVREHYPLLAEAIRTVASYQLRNRATIVGNICNASPAGDTIGACMLYGGVLKVFGADGVREEPLATFFKGPGKTNLKPGDIALSLHLPLPPKGHVGRYIKVARNKLGDLAIVGVSVLGYPDATVASGFRFLIALASVAPVPLRVPVAEKVLAEKKIDEATIAEAAQIAMDSCSPIDDVRGSAQYRKHMVRNMTRRAVTEVWQKLTQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N4</accession>
    <name>E8N1N4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterioferritin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bfr</name>
        <name evidence="2" type="ordered locus">ANT_06050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06050"/>
    <dbReference type="EnsemblBacteria" id="BAJ62639">
        <property type="protein sequence ID" value="BAJ62639"/>
        <property type="gene ID" value="ANT_06050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06050"/>
    <dbReference type="eggNOG" id="COG2193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122243_0_0_0"/>
    <dbReference type="OMA" id="LAHEYQA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="1">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="145" mass="16283" checksum="41CF122F6ABC39DA" modified="2011-04-05" version="1">MEDTMDKETLIAHLNEDLAGELGAIIQYITYAAKASGPFRPQLAQFFLAEVPDEQLHAQFLANKIVALGGEPTTTPRPVPPARNNREMLEAVLEAERKARADYTRRAEEAEAFGDKGLAVQLENMVLDESNHAEETERILREWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S2</accession>
    <name>E8N1S2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559072.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06430"/>
    <dbReference type="EnsemblBacteria" id="BAJ62677">
        <property type="protein sequence ID" value="BAJ62677"/>
        <property type="gene ID" value="ANT_06430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06430"/>
    <dbReference type="HOGENOM" id="CLU_1145361_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225219" evidence="2">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="26662" checksum="0828217E1DABA089" modified="2011-04-05" version="1">MKRLQFHGWMGLLVLTMLVVSACTPPAPAATPTPVSTDTPQPSATATPTATLTLTPTVTATPTQTPTSTLTPTLAPSFEQAKVIELRYQTVGGYQITMVVPAVNAPYNVILGGINFKCSFDEKYPDRLFCFGLAKPPMDQSITLAFLHPDTGKVIYQGKIVLDSRALPTPVPSGYSQYDCPDRGKNVTCEIECRIAPDGVPCMVATCFDACGPYYSVHTCPEDVSQWNMCNDELLREMKSRYNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N251</accession>
    <name>E8N251_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561342.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29720"/>
    <dbReference type="EnsemblBacteria" id="BAJ64998">
        <property type="protein sequence ID" value="BAJ64998"/>
        <property type="gene ID" value="ANT_29720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29720"/>
    <dbReference type="eggNOG" id="ENOG5030TSE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133746_0_0_0"/>
    <dbReference type="OMA" id="THWPSAS"/>
    <dbReference type="OrthoDB" id="2002817at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="167" mass="18139" checksum="2C7CFA107D69EB8D" modified="2011-04-05" version="1">MESIGFICFVGLTLIFAAVGGFALWTYFKDRQKAEASKQWMAVNGRVVESRVEVREGYDEDQGTTRSYAPHVEYEYEVNGTVYRSTKLQAGTRVFVSSRGRAEAEVARYAPGTPVTVYCDPANPAEAVLQPGKSSKAGLVIGIVFLVISGMILCLFLITVLIGAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N256</accession>
    <name>E8N256_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561347.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29770"/>
    <dbReference type="EnsemblBacteria" id="BAJ65003">
        <property type="protein sequence ID" value="BAJ65003"/>
        <property type="gene ID" value="ANT_29770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29770"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1238099_0_0_0"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="223" mass="23652" checksum="E47CB057098A875F" modified="2011-04-05" version="1">MSPFTALLTSAGREPTKSIALALAEPGARLALTDLTPMGLEDTAALVQAQGAEVSTHVADPSKGLAVRMLLDEVLERWESLDALINCPLAQPTAGMLELDEWDFQRTLESNIGGPFLMLQALGRIWREERRGGIVLHVITGGGARPPDAGKFAFTASQAGLRALTRSAVELAPLGIRVYGVCLESVHPRGALVAARLAAQILHGQVQAEPGTLFEVDNTGDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D2</accession>
    <name>E8N2D2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M42 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_07040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559132.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07040"/>
    <dbReference type="EnsemblBacteria" id="BAJ62738">
        <property type="protein sequence ID" value="BAJ62738"/>
        <property type="gene ID" value="ANT_07040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07040"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053520_0_0_0"/>
    <dbReference type="OMA" id="HGMERTH"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="349" mass="38143" checksum="04BFDC404E371D9D" modified="2011-04-05" version="1">MISLPAIDTADLVNFLTRLLNTPSPTGFTHRALSLTEQALEGLPVTMRRTRKGALVIRWEGERNTAPRGLTAHVDTLGAMVKEIKPNGRLKLTKVGGFAWNTVEGENCTVFTRSGREVRGTLLLTKASSHVHSSAVSETKREDDAMEVRLDERTTSAEQTRALGIEVGDFVAFDPRVEVINGFVRSRHLDDKACVACVVAAFKALHAAGKKPAQTTIALISNYEEVGHGAATGFPPEMSELLVVDMAAVGDGQNSDEFHASLCVKDSRGPYHHEMSNRLRDLAEAHQIPYRVDIYPYYGSDGEAYWYAGGDVAVALIGPGVDASHNYERTHIEALEATTRWILAYLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G2</accession>
    <name>E8N2G2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="5">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">ANT_07340</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559161.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07340"/>
    <dbReference type="EnsemblBacteria" id="BAJ62768">
        <property type="protein sequence ID" value="BAJ62768"/>
        <property type="gene ID" value="ANT_07340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07340"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_3_0"/>
    <dbReference type="OMA" id="ICIGPIS"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="814"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="15">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAJ62768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="848" mass="94273" checksum="35AA54A3520E8A35" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G7</accession>
    <name>E8N2G7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative basic membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559166.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62773">
        <property type="protein sequence ID" value="BAJ62773"/>
        <property type="gene ID" value="ANT_07390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07390"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_1_0"/>
    <dbReference type="OMA" id="NARYYEG"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225232" evidence="3">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="32"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="344" mass="37274" checksum="5D0C345C20E72097" modified="2011-04-05" version="1">MKKSLLVLLIALFVFSLAACTPAAKTQEQPKRVVYLINGALGDNAFYDSGKAGIDNIAKQYGVETRTIECNFDAGKYEPSLRAAVDYADVIFVISYGFEDQLKEFADQYPNKIFVNIDTVVENSKKTITSVDFIEEESAYLAGVVAGLTTLDTSIPNVNPDKVVGVVGGDVDPVVSAFVFAYENGAKSVDPEIQVLKKSLGGAWDDSARGKQAALQLYDQKADVVFQVAAAAGIGVLQAARERQLYAIGVDTNQNDLEPGYVIASDIKNVGKSIEDVYKTIHEGTYKPGQVLKYGIAQGGVDIALEAKVQVLPQSIVDKVLAIRQQIVDGTLKIEMYNNQDVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K8</accession>
    <name>E8N2K8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559207.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07800"/>
    <dbReference type="EnsemblBacteria" id="BAJ62814">
        <property type="protein sequence ID" value="BAJ62814"/>
        <property type="gene ID" value="ANT_07800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07800"/>
    <dbReference type="eggNOG" id="COG1437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105244_0_0_0"/>
    <dbReference type="OMA" id="LECELKY"/>
    <dbReference type="OrthoDB" id="1536958at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="204" mass="23152" checksum="67F73B0731A28972" modified="2011-04-05" version="1">MNSSEQEIEAKFPVHSLEGVRQRLEQAGAVLEAPRVHEVNLRFDTPDGALTRERRVLRLRRDSRSILTYKGAAKMGQEVSVRQEIEVEVSDFEAARHLLEALGYRVSILYEKFRTAYQLAGVHVVLDEMPFGNFVEIEGENAEQIHQIALSLGLCWEARVAESYLGLFERVRQAYGLPPTHLTFDALRGVKVEFSRIGLQEADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P8</accession>
    <name>E8N2P8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">surE</name>
        <name evidence="7" type="ordered locus">ANT_08200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559246.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08200"/>
    <dbReference type="EnsemblBacteria" id="BAJ62854">
        <property type="protein sequence ID" value="BAJ62854"/>
        <property type="gene ID" value="ANT_08200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08200"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_2_0"/>
    <dbReference type="OMA" id="YVGEYGK"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="262" mass="28436" checksum="4F889F3E4416C8C8" modified="2011-04-05" version="1">MHIMVTNDDGINAPGLLALANAMKPLGQVSVLAPERNWSSSGHVRTLDRPLRVKSVQMDHELTGHACDGAPSDCVALANAGFFNEKVDLVISGINSSANLGHDVTYSGTVTAAMEAAIWGIPAIAFSLDIPETLETPPDYSTAARVAREIVAATIQYGLPPHLLLNVNIPYLPFEEIRGVQITRMGLRVYHDQLDRRLDPRGRPYYWTIGGSPTGVPERGTDIGAIHEGYVSVTPLQLDLTAFHFIPEMNTWQWNGLSSKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U3</accession>
    <name>E8N2U3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaK</name>
        <name evidence="10" type="ordered locus">ANT_30670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561434.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30670"/>
    <dbReference type="EnsemblBacteria" id="BAJ65093">
        <property type="protein sequence ID" value="BAJ65093"/>
        <property type="gene ID" value="ANT_30670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30670"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_0"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="527"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ65093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="621" mass="67633" checksum="C0A3D62F5ADC371F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y0</accession>
    <name>E8N2Y0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561471.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31040"/>
    <dbReference type="EnsemblBacteria" id="BAJ65130">
        <property type="protein sequence ID" value="BAJ65130"/>
        <property type="gene ID" value="ANT_31040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31040"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1222701_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="226" mass="26195" checksum="A9421802D19A62A6" modified="2011-04-05" version="1">MKKTIHCPSCGAPLDSTSTHCTYCGTQIKKISTRQQQEARIKELRRAVVGRTPTFDEAMELAKLYTNLGQSAHAEEYLRQAIALNPDAPQPRILLCLSLLGFNRPTTSSRMYADEIREHFNWLYQHHPRMREVEWLGYFLTMEYFMEAQDWRRGLETGRLAVEKFPENYLLQFMYGLALVHFGDTDGLDAQDYRQALHHFRLSAELNPEFEPAMKNASALENYLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N309</accession>
    <name>E8N309_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561500.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31330"/>
    <dbReference type="EnsemblBacteria" id="BAJ65159">
        <property type="protein sequence ID" value="BAJ65159"/>
        <property type="gene ID" value="ANT_31330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31330"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_3_0_0"/>
    <dbReference type="OMA" id="GVVWDFN"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228603" evidence="1">
        <location>
            <begin position="28"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="41200" checksum="593C3237F656FF11" modified="2011-04-05" version="1">MFFSGKSHWVRLLSLVLLVAMLASCTATPTAKPAEPGADNGALQPLVDAAKQEGTLTTIALPHDWCNYGEAIETFKAKYGIKVNELNPDASSAEEIEAIKANKESKGPQAPDVIDVGYAFGPQLIDEGLAMPYKVSTWDSIPANLKNADGYWYGDYYGVMAFEVNKDVVQNVPQDWADLLKPEYKNQVALAGDPRISAQAQMSVYAAALASGGSLDDVQPGLEFFKKLNEAGNFVPVIAKQSTLAKGETPVVLRWDYNALADKKALEGNPEIEVVIPKSGVIAGVYIQAISAYAPHPNAAKLWMEFLYSDEGQLIWLKGGCRPVRFDDMLKRNAIPQDLLAQLPPAELYAKAVFPSIEQLNAARAAIAENWDKVVGADVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N330</accession>
    <name>E8N330_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recF</name>
        <name evidence="9" type="ordered locus">ANT_31560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561520.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31560"/>
    <dbReference type="EnsemblBacteria" id="BAJ65180">
        <property type="protein sequence ID" value="BAJ65180"/>
        <property type="gene ID" value="ANT_31560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31560"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_0"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ65180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="413" mass="46384" checksum="63C0176024656CEA" modified="2011-04-05" version="1">MHLTHLSLTHFRLFARLDMELPRRTLLLVGENAQGKTSLLEAIYYLATFTSLHASLDRQIVSFAAAREPLAVARIVGDFEREGRAHRLEVRLILEANGGFPPARFRKEILLDGVKRTAQEATGALTAVMFLPDMTHILDGSPEERRRYLNLALAQAVPGYAQALTDYTRALEQRNALLKLLQERSADPAQLAYWDTLLAEKGAFILHARIAAIAELERLAARIHNRLTGGTEVLQFVYLPAYDPLPHPEGQYALPILTPMDRGGFSLTQLREGFLQRLSDLRSEEIARGVTTIGPHRDELRFLSNGVDLGDYGSRGQLRTTLLSLKMAEARWMKERTGEFPILLLDEILAELDDRRRADLLDALDDFEQAVLTTTDLKLFAPPFLSRCTVWRVTQGVVQTESPQQGEQLSPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N341</accession>
    <name>E8N341_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_31670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31670"/>
    <dbReference type="EnsemblBacteria" id="BAJ65191">
        <property type="protein sequence ID" value="BAJ65191"/>
        <property type="gene ID" value="ANT_31670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31670"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_3_0_0"/>
    <dbReference type="OMA" id="SHYPEAN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ65191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="181" mass="20529" checksum="C3FB07E298691AC1" modified="2011-04-05" version="1">MCLPSRAEGRAPCYNLTMPILDARTFEFFSRSAEQTRRLGGRLGMLLNVGDLVCLSGDLGSGKTTLVQGMAQGWGSLDPVSSPTFILVNEYRRADGACLFHLDAYRLTNVEEAEELDFERMLECGVLVVEWPEHIQPALPAECLWVSLRYVEEEQRHLLFQSRGTRYDALLNEFRQKVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N375</accession>
    <name>E8N375_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08550"/>
    <dbReference type="EnsemblBacteria" id="BAJ62889">
        <property type="protein sequence ID" value="BAJ62889"/>
        <property type="gene ID" value="ANT_08550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08550"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_3_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="143" mass="16093" checksum="A545DF037C567875" modified="2011-04-05" version="1">MPFSACLRISILYNIFIVMNISSAALQEIADFFEVLAVPTRLGILLAIGEREVCVCHLEAVLKLRQAAISQHLQVFKKNGWVISRRQGRFVYYKLSNPSVLPLIYEGARMKGVSQEQIEYFFTAPIEGCSCSLCNPNSNKPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>E8N385</accession>
    <name>E8N385_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">glmU</name>
        <name evidence="18" type="ordered locus">ANT_08650</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559291.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08650"/>
    <dbReference type="EnsemblBacteria" id="BAJ62899">
        <property type="protein sequence ID" value="BAJ62899"/>
        <property type="gene ID" value="ANT_08650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08650"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_0"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="139"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="250"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAJ62899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="455" mass="49537" checksum="7D7FC2DEA825C409" modified="2011-04-05" version="1">MKVLPVILAAGQGVRMRSRLPKVLHPLAGRPLIQHALRIVQQVADVPPIVVIGHQADQVRAALDESVRTALQEEQLGTGHAVMSAEALARGQSDLVLITYGDMPLLRPETLRALIEVQKNNRGPLSLLTVEMEDPHGFGRIIRDEEGRVTAIVEEAVATPEQRAIRELNTGVYCIRNEWLWDALRKIQRSPKGEYYLTDLVEIAVSEGLEVQAVCLKDPEEALGINTRVHLAEAEAVLRKRIARHWMEAGVTIIDPASTYIEADVTIGMDTVIYPNTYLRGKTSIGENCVLGPDTIIEDSQIGNHCTVLASVIESSLLEDDIRMGPFCHLRPKAHLAKGVKMGNFGEVKASYLGPGVHMGHFSYIGDAIIGAHTNIGAGTITCNFDGKNKHRTEIGEDAFIGSDTMLVAPVKIGARARTGAGSVVTHDVPDDETVVGVPARPFKKTSQERTPQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>E8N391</accession>
    <name>E8N391_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">dnaG</name>
        <name evidence="17" type="ordered locus">ANT_08710</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559297.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08710"/>
    <dbReference type="EnsemblBacteria" id="BAJ62905">
        <property type="protein sequence ID" value="BAJ62905"/>
        <property type="gene ID" value="ANT_08710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08710"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_1_0"/>
    <dbReference type="OMA" id="PVKQIWK"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="255"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="14">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAJ62905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="632" mass="72385" checksum="D235B4DA0FAA69D9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B7</accession>
    <name>E8N3B7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_08970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559323.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08970"/>
    <dbReference type="EnsemblBacteria" id="BAJ62931">
        <property type="protein sequence ID" value="BAJ62931"/>
        <property type="gene ID" value="ANT_08970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08970"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_1_0"/>
    <dbReference type="OMA" id="LAYDFID"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225444" evidence="4">
        <location>
            <begin position="25"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="445" mass="48617" checksum="9353F09C3D11C6B9" modified="2011-04-05" version="1">MNRFVHSMLVVLLVFGLLAGCTPAATPQQPAEPTKAEQPQQVTLKVWDILVNPTEDEVAKTLIAEFEASHPGVKIERETMTFDQMKSRAKLGLSAADGPDVAQINQGYSDMGALVAANLLVDLTPYAKKYGWDKKLSPGIVARNSFTPDGKTLGEGNLYGVPITAELVGVFYNKEHFEKAGVTVPKTFAEFEAALEKFKSAGIVPINYGSLDGFVNIHVFAEIQNLKIDRAYLDDFIYGRNNVSFNIPANVEAAAKMQEWVKKGYFTPDFSGIGYDDSLAAFRSGQGAMMITGSWISGDAIAQAPGKFGFFLMPPLEEGGKRMSTGGTSTAFAIRKGTANEELAAQYIDWMVSDRAAQLWAEKGIVPVGKVEVKDADPLFVDLLKAWAYLNENDLVGHYLDWATPTFYDTIVAAFAELMALKITPEGFVQKVEADYAAYLKTRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3D1</accession>
    <name>E8N3D1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62945">
        <property type="protein sequence ID" value="BAJ62945"/>
        <property type="gene ID" value="ANT_09110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09110"/>
    <dbReference type="HOGENOM" id="CLU_1665794_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="158" mass="17439" checksum="EE020532202373C0" modified="2011-04-05" version="1">MGGKMIFEESPSLELYKKGIPEKLPDPHRRKKILWGAISALMVVVLVLGGIRMKQSGALDWLTGKGTLTGVVVDDFHRPIPADVYLLDLDRSTRCDEFGRFTFEGVPAGTHTILIAYRVAGREYPAQVFSGRINDAGTLRFLPGDFDHGWSQAVNALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J0</accession>
    <name>E8N3J0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mreC</name>
        <name evidence="7" type="ordered locus">ANT_09700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559395.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63004">
        <property type="protein sequence ID" value="BAJ63004"/>
        <property type="gene ID" value="ANT_09700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09700"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_1_0_0"/>
    <dbReference type="OMA" id="NPFTHRI"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="280" mass="30354" checksum="5AF07FFB60005073" modified="2011-04-05" version="1">MTGFLERFWRTGVIFLIVAGLLFLALGGYLNPMVRLASTPWIAAQRWLMTRYLAFYELVSSPQEMAALRQQVAALEEENARLRSQVIELQQELSRAQTTSALLDFARSRPGDRFVGASVIGRDPSPFLQYVFIDKGSDDGLRRGMPVVTAEGLVGRIDAVIANGARVQLITDPGAAVNVKIASSEVEAILSGSLTGELTLEMLPQEATLKVGDVVLTSGLGGNYPENILVGQIAALRQQETTLFQTAVVQPAVDFRTLRTVLVITNFAPVNLSPLQPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J5</accession>
    <name>E8N3J5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division topological specificity factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">minE</name>
        <name evidence="4" type="ordered locus">ANT_09750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MinE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09750"/>
    <dbReference type="EnsemblBacteria" id="BAJ63009">
        <property type="protein sequence ID" value="BAJ63009"/>
        <property type="gene ID" value="ANT_09750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09750"/>
    <dbReference type="eggNOG" id="COG0851">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137929_1_2_0"/>
    <dbReference type="OMA" id="VHDRANV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00262">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036707">
        <property type="entry name" value="MinE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55229">
        <property type="entry name" value="SSF55229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01215">
        <property type="entry name" value="minE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="87" mass="10060" checksum="62BDD45E011809DB" modified="2011-04-05" version="1">MAGWLDWLMGQRNKSADQAKERLKLVLINDRTDLSPAQMEQLKNDLLAVIERYIAIDPARVHITMSQEGREHRLLADIPLKPATRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J6</accession>
    <name>E8N3J6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rod shape-determining protein RodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mrdB</name>
        <name evidence="7" type="ordered locus">ANT_09760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559401.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09760"/>
    <dbReference type="EnsemblBacteria" id="BAJ63010">
        <property type="protein sequence ID" value="BAJ63010"/>
        <property type="gene ID" value="ANT_09760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09760"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_1_0"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="375" mass="41890" checksum="29A7E196800DFA2A" modified="2011-04-05" version="1">MIQRETWKHFDYWLLGAVVILSVFGIAMIRSAIAGNEVLAELVQRQTIYVIIGFVVILFMASLDYRYFSALSQVLYIGAIVSLLIIFVFGTAFFGSARWLDTGLILIQPSELAKIIMIIVLADFFARTRDRKKDLRWIFQSFLLTFGVVIWILLQPNLSTSIVIMVIWFSMLWVSGLPVKYLWILLGVSIVLLLVIILMLFSGQKIPFIEDYQLKRIVDFLFPDPNSRHGNIFNVQQALISIGSGGLFGSGYGHSTQVQLRFLKVRHTDFIFSAMAAEFGFVGTVVIILLLVFVIIRCFRAAAIAADPFGALIAYGFGVLLFFQMAVNIGVNLNVIPVTGLTLPFISYGGSSMLSLAFGIGLVESVVSRHKVLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L6</accession>
    <name>E8N3L6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gmd</name>
        <name evidence="6" type="ordered locus">ANT_09960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63030">
        <property type="protein sequence ID" value="BAJ63030"/>
        <property type="gene ID" value="ANT_09960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09960"/>
    <dbReference type="eggNOG" id="COG1089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_14_0_0"/>
    <dbReference type="OMA" id="FVKSSWQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="377" mass="43536" checksum="655FD7A06ECCBC10" modified="2011-04-05" version="1">MPGRVWYTLALVDFCLGGKKLKKALITGITGQDGSYLAELLLSKGYEVHGMIRRASTFNTRRIDHIYRDPHANGDPVHLYLHYGDLTASDTLLDIIYNIRPDEIYHLGAQSHVRVSFDMPEFTGDVTGLGTARILEAIRKSGVKARFYQASSSEMFGSAKPPQNEQTPFEPRSPYAVAKLYSYWLTRNYREAYNIFAVNGILFNHESPRRGETFVTRKITRALASIRAGKQKVLYLGNLDSKRDWGYAPEYVEAMWMMLNRDEPDDFVIGTGEAHTVREFLDEAFGYLDMDWHEYVKIDPRYFRPTEVDYLLADASKARRVLGWEPKVRFRELVRIMVDADLELMGLECPGEGKRILQERFGNWHRWEKQVISMDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Q4</accession>
    <name>E8N3Q4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rplM</name>
        <name evidence="5" type="ordered locus">ANT_10340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559459.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63068">
        <property type="protein sequence ID" value="BAJ63068"/>
        <property type="gene ID" value="ANT_10340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10340"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_0"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="143" mass="16055" checksum="DE4BD54071943E63" modified="2011-04-05" version="1">MAVEKTFVLKGKPESQWLLVDATGKGLGRLATQIAHYLMGKHKPTYTPGVDMGDYVVVINALQLDIPKERLTTKIYYRHSNYPGGLKAISLRDQLQKHPERVIRAAVWGMLPHNKLGRRLIEKLKVYPGSEHPHAAQKPTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V1</accession>
    <name>E8N3V1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cmk</name>
        <name evidence="10" type="ordered locus">ANT_10810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559505.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10810"/>
    <dbReference type="EnsemblBacteria" id="BAJ63115">
        <property type="protein sequence ID" value="BAJ63115"/>
        <property type="gene ID" value="ANT_10810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10810"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_0"/>
    <dbReference type="OMA" id="RAITWWM"/>
    <dbReference type="OrthoDB" id="776861at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="7"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="226" mass="25299" checksum="C06268A84107F882" modified="2011-04-05" version="1">MNKPKTIAIDGPAASGKSTIAEKLANELGYLFFDTGVMYRAVTLAALRRLGNVRDEQAVTRLAERVWIDVRPPSKDDGRKADVLLDGEDVTWAIRSSEVDAHVSIVSAYPGVRAAMTRQQRRIGERGEVVMVGRDIGTVVLPEAELKIYLDASLEERARRRYLENKSRGMDANYDEILENLRKRDEIDSTREVAPLRIAGDAHVVMTDGLTIEEVMQQVRKLAHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Z5</accession>
    <name>E8N3Z5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative two-component hybrid sensor and regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_11250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559547.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63159">
        <property type="protein sequence ID" value="BAJ63159"/>
        <property type="gene ID" value="ANT_11250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11250"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237644_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007892">
        <property type="entry name" value="CHASE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05228">
        <property type="entry name" value="CHASE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="842"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1158"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1396"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1542"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="11">
        <location>
            <begin position="1721"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="645"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="1446"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="1593"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="4">
        <location>
            <position position="1760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1819" mass="205515" checksum="41C66882DC0CFEC0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N420</accession>
    <name>E8N420_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_11500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559572.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63184">
        <property type="protein sequence ID" value="BAJ63184"/>
        <property type="gene ID" value="ANT_11500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11500"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507895_0_0_0"/>
    <dbReference type="OMA" id="NRYPAYW"/>
    <dbReference type="OrthoDB" id="2075193at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="65"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="531" mass="60387" checksum="9B5F1E9FA46E0A24" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N434</accession>
    <name>E8N434_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559586.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11640"/>
    <dbReference type="EnsemblBacteria" id="BAJ63198">
        <property type="protein sequence ID" value="BAJ63198"/>
        <property type="gene ID" value="ANT_11640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11640"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079846_0_0_0"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="12885" checksum="6D59C412E93643A4" modified="2011-04-05" version="1">MAKSASQPVALNPDTLTPATPAEFLTRGWLYYARGNYKAAEEDFRKALETNANDPEALYALGLNLLAAGRSQEAVEIFEKASNAAGAIDDHVRASMIQRLIKGHINRIRTGNWNLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A6</accession>
    <name>E8N4A6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559658.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12360"/>
    <dbReference type="EnsemblBacteria" id="BAJ63270">
        <property type="protein sequence ID" value="BAJ63270"/>
        <property type="gene ID" value="ANT_12360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12360"/>
    <dbReference type="eggNOG" id="COG2350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110355_6_1_0"/>
    <dbReference type="OMA" id="MEPHMAW"/>
    <dbReference type="OrthoDB" id="1780176at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="100" mass="11489" checksum="20BFAE9DC6E52F97" modified="2011-04-05" version="1">MKHFLIEITYTVPFSTLEAVVPEHRAFLQTGYDKGWLLLSGPMNPRTGGIVVARAPSQEDLQYFFSGDPYALRGFALYRFVEFDPVKYQPFLAEWIQEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J5</accession>
    <name>E8N4J5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glk</name>
        <name evidence="1" type="ordered locus">ANT_13270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559746.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13270"/>
    <dbReference type="EnsemblBacteria" id="BAJ63359">
        <property type="protein sequence ID" value="BAJ63359"/>
        <property type="gene ID" value="ANT_13270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13270"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_0"/>
    <dbReference type="OMA" id="VNVPGWR"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="32651" checksum="D37CBDF629DD1E5A" modified="2011-04-05" version="1">MDYYIAVDIGGTQLRAALYPEGEQKAVSQKRIPTQTKDQSPVDRLLELIKNIMPSQGKVKAIGMAAPGPINPKTGILYAAPNIPGWVNLPLAQIVQDRFKVPTLLGNDANLAAMGEWKFGAGRGYQHLLYMTVSTGIGGGVIEEGKLLLGYKGLAAEIGHITVDPNGPLCGCGQRGHLEALASGTAIARYVSEQLASGVPSSMAELPAVTARDVSLAAEQGDPLAREALARAGRYLGRAIADFLHLFNPQIVIIGGGVSRSGRYFLDPLRNSIAEYVISPEYLHGLVVTTASLGDDAGLLGALALAQTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J8</accession>
    <name>E8N4J8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_13300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559749.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13300"/>
    <dbReference type="EnsemblBacteria" id="BAJ63362">
        <property type="protein sequence ID" value="BAJ63362"/>
        <property type="gene ID" value="ANT_13300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13300"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_0"/>
    <dbReference type="OMA" id="HERAICE"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="172"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="306"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="521" mass="57868" checksum="7DDD4E2B4EC4E2A0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K4</accession>
    <name>E8N4K4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559755.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13360"/>
    <dbReference type="EnsemblBacteria" id="BAJ63368">
        <property type="protein sequence ID" value="BAJ63368"/>
        <property type="gene ID" value="ANT_13360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13360"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_5_0"/>
    <dbReference type="OMA" id="YRMFECD"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="10"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="250" mass="28003" checksum="BF989E174B2494AA" modified="2011-04-05" version="1">MNEFRLRHETLIIAHRGASAYAPENTLAAFRLAIEQGADAIELDAKLSADGHVVVIHDPTVDRTTNGKGWVHRLTLAELKNLDAGRFFSAKFSGEPIPTLEEVFVEIAPSLLVNVELTNYASPTDALVEKVCHLVKKYHLEDRVLFSSFHPLNLIRARQILPEVPVALLALEGRGGWWARSFVMRGLSPEFLHPYYTDATALFIQKQHQKGRRINVWTVNQVNAMQELVQNGVDGLITDDPLLAREVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4M9</accession>
    <name>E8N4M9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63393">
        <property type="protein sequence ID" value="BAJ63393"/>
        <property type="gene ID" value="ANT_13650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13650"/>
    <dbReference type="HOGENOM" id="CLU_1340948_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="204" mass="23309" checksum="2757112444693C25" modified="2011-04-05" version="1">MGKGEHLPFFLNWSTWLSLHASPASLKKYALLSLLLFFTYQGLAWGFYQLNEQQGLLELGCAPHFLQSPIGALSIEGAISLRQSLTVWTLIFHGVLSLFRLVPVLTFGVWLSMGLTYFFGVRLLAPKMNRLLLVFPALYVVSEILQTIIAFWILLLPEIELGKGVPWFNLFQRFSLWLGFASLGLVLIGWLLWRIFEFILHHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V3</accession>
    <name>E8N4V3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559849.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63467">
        <property type="protein sequence ID" value="BAJ63467"/>
        <property type="gene ID" value="ANT_14390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14390"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_6_0"/>
    <dbReference type="OMA" id="CYEVSDR"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017700">
        <property type="entry name" value="Aminohydrolase_SsnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03314">
        <property type="entry name" value="Se_ssnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="56"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="452" mass="50905" checksum="ED8ECA4A1EB03B6C" modified="2011-04-05" version="1">MLILRCQIVRWSEPNEILYNAAVLVRDGKIVDFGPSKDLEERYPQEEKLDANGQWLMPGNICAHTHFYGAYARGMSVYGTPPADFPQILRKLWWGLDKALSEEDVYYSALVCLMDAIRHGTTTLIDHHASPNAIDGSLDQIAKAVEESGVRASLCYEVTDRDGVARRDAGIRENVRFLQRLQKGDNLDGRLSGMFGLHASLTLSDETLRKAREAVPEHIGFHVHVAEHSVDEYDSLQKSGMRVVDRLSHFGILGPRSIAVHAVHVDAQEIFQLSRTQTWVTHQPRSNMNNGVGTAQVESMMRAGIRVCLGNDGHSNTMWQEWKFAYFLHKHANLDPRRMGADQVVQMGVYNNRALVETLFSGKKVGAIEVGAEADLILVDYHPYTPVTEANLPWHIIFGMQESMITMTMVAGKVLMRDRKLITLDEQGISEAVLARVPATWERYRKLMEQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W3</accession>
    <name>E8N4W3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_14490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559859.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14490"/>
    <dbReference type="EnsemblBacteria" id="BAJ63477">
        <property type="protein sequence ID" value="BAJ63477"/>
        <property type="gene ID" value="ANT_14490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14490"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040786_0_0_0"/>
    <dbReference type="OMA" id="KNICRCT"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="320"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="472" mass="51359" checksum="8C9C5F4432271843" modified="2011-04-05" version="1">MWKRYCLVTRIEEALEWLAKEKEKARVIAGATDLILEMERGGRKDVETLIDISRVSALDTISLDEDGWIHLGPLVTHNQCATSHLLYDRAYPLARACWEVGSPQIRNRGTVAGNLITASPANDTITPLMALGAVLTLRSQRGERRVPLKEFYTGVRRTVLAPDEMLVDIAFPAMRSSQKGTFVKYALRKAQAISVVNLAVLLDFDEQNIIQSAQITLGSVAPTIIHARSAEEYLTGKVLMPEVILEAAERCMGDAKPISDIRGSAQFRKKITGVIAKRALQAIAGGNEREGMPRVPITLSIRKMNSSLSESIVFEEHSAPPIICKVNGEERVFHSGHHKTLLRLLREDGLLIGTKEGCAEGECGACTIILDGMAVMSCMVPAPRAHGAEIVTVEGLAQGETLHPVQKAFVEAGAVQCGYCTPGFLVSAAMLLKEKSKPTRGEIVQAFSGNLCRCTGYYKIVEAVEKAVEKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N523</accession>
    <name>E8N523_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_15090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559919.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15090"/>
    <dbReference type="EnsemblBacteria" id="BAJ63537">
        <property type="protein sequence ID" value="BAJ63537"/>
        <property type="gene ID" value="ANT_15090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15090"/>
    <dbReference type="eggNOG" id="COG1819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044082_0_0_0"/>
    <dbReference type="OMA" id="SNFGWDF"/>
    <dbReference type="OrthoDB" id="700931at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="364" mass="41326" checksum="55298B5EB1ED0D57" modified="2011-04-05" version="1">MIRIAYFITPHGFGHAARATAVMLACLQKCQDLWFEVYTTVPQWFFEDSRLINYTIHPLACDVGMVQKNSMEEDIPATIKALQYFYPVNKQLIEELSREFSEKEIRAVLCDVAPLGILAAHQARIPSLLIENFTWDWIYEGYLSEEPDFQPFIEYLQGVYRQVIYHIQTQPACSVSTQADLNVFPVSRPIYSSREEIRKSLTIPQDVPAVLITMGGIESNQFPFEVLKKMPNVVFIVPGGAKTPYKQANLILLPHRSGYYHTDLMNACDAVIGKLGYSTLAEAYWTGTPYGFIPRARFRESPPLAVFAKETMGGLEIPMESFWGEPLLSFIEYLIQIPKKNAVMNGSEQIADFLMGLVNQKTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N533</accession>
    <name>E8N533_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63547">
        <property type="protein sequence ID" value="BAJ63547"/>
        <property type="gene ID" value="ANT_15190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15190"/>
    <dbReference type="eggNOG" id="ENOG5033KPB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1631950_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="162" mass="17506" checksum="C2D7FFA5A9BD5027" modified="2011-04-05" version="1">MKHPFQFSVTPWVILGSIIIAGALSVLLILGLSLTASRLQSQEIPAMITVIPAPTMLPTSTLLYTSTPEATFIEINGISLGKFVQIAGTGGDGLRLRAGPGKEFAPLFLGYESEVFEVKDGPKFSDGITWWYLIAPYDETRSGWAAADYLKVVNVELEDSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N536</accession>
    <name>E8N536_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">ANT_15220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63550">
        <property type="protein sequence ID" value="BAJ63550"/>
        <property type="gene ID" value="ANT_15220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15220"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_0"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="14">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ63550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="224" mass="24523" checksum="54653BD893083C14" modified="2011-04-05" version="1">MNSFRLCASVLSADFRCLEDQVKQLEEAGVDEIHVDVMDGHFVPNLTMGPFIVSTLKRITHLPLDVHLMVENPDRMIPWYAEAGAHRLSVQVETCPHIHRTLQNIHSLGCEAGVVLNPGTPASWLEEVVSHADLILVMTVNPGFSGQSFLPEVLPKIAKVRDLVENSHSRAVIQVDGGIDQKTLPLVYAAGARYIVSATAIFKHPEGIKAGVNALRESVQKNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N551</accession>
    <name>E8N551_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15370"/>
    <dbReference type="EnsemblBacteria" id="BAJ63565">
        <property type="protein sequence ID" value="BAJ63565"/>
        <property type="gene ID" value="ANT_15370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15370"/>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_571920_0_0_0"/>
    <dbReference type="OMA" id="EVCFRYN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017587">
        <property type="entry name" value="YqeC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19842">
        <property type="entry name" value="YqeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03172">
        <property type="entry name" value="TIGR03172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="285"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="477" mass="52675" checksum="A02EA9532643C7CB" modified="2011-04-05" version="1">MKYRKFILHDLSFFKHESILKKMSISRTMALRKALNLPETPVLAIVGSGGKTSLLFRLAKEYTPRVIVSNTAHLGVNQAENADKVVQLREPQDIPRILDETFDGILLITGLPDERGRYRGLEHTAISLLIDVCKQKRIPLLIEADGCRGKPLKAPGPWEPPIPQKIEQVIVCAGASGFGKPLNEEWVYRSADYSQLANVSLGDLLSSETIAKVISHPLGGLKNIPENSKRYFLINQADSVEQQEFGGNVAIRILSKFDRGVVASLHGTEYTKPVEIHRVYVPVAGVVLAAGESRRFGSPKVLIEIEGEPLVRRIAKIALESYLQPVLVVTGAYPEISSSLSNLDVNIIENPSWKLGQSSSVKVAISALPEHVQAVIFLLGDQPFITSSLLKSLLHAFAISQAPIIAPRVNGQRANPILFSRETFHDLMNMTGDAGGRQIFEKFPLQFIPWEDKKLLLDIDTLDDLANLMKLIDHSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N566</accession>
    <name>E8N566_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_15520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15520"/>
    <dbReference type="EnsemblBacteria" id="BAJ63580">
        <property type="protein sequence ID" value="BAJ63580"/>
        <property type="gene ID" value="ANT_15520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15520"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_15_0"/>
    <dbReference type="OMA" id="HDSIGHE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="185"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="377" mass="41752" checksum="F2DEDD05DE0EDBAE" modified="2011-04-05" version="1">MAFAVMVLAGYFTTFTSVRSLSFEWLTLMILLGIGYLTTGVYGYARVAHDDRLLIRVGYFLLQIPLGALSIILSGQVGFNAIILLPLVGHSVFLLPEAWKYLINLLIVFSYGAIVHLMTASWEFVWASVPVFGAGQVFILVFTQMMLNEEKARREIESLVVQLREANDRLREYAIQAEELAIVKERNRLAREIHDGLGHYLTTLNMQIKAASAVLETDLEAARQLLAKAEGVTHKALLDIRQSVRALRDPSLPVKSVEEILAGLLEECEHSGIHTLMEVKGEPRKVDQELKASIIRLVQESISNTLKHSKATLYQLVLDYQSDCIILEMKDNGVGGEISAVGFGLLGMQERVALLKGKMEIATTNGAGFSIKIILPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N575</accession>
    <name>E8N575_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15610"/>
    <dbReference type="EnsemblBacteria" id="BAJ63589">
        <property type="protein sequence ID" value="BAJ63589"/>
        <property type="gene ID" value="ANT_15610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15610"/>
    <dbReference type="eggNOG" id="COG1912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_1_1_0"/>
    <dbReference type="OMA" id="EIPYQKA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="28667" checksum="04848CFE26AE2D25" modified="2011-04-05" version="1">MNIITILTDFGLQDGYPGVMKGVIYRIAPSVQIVDISHQVPPQNISRGARILERSYAFFPPGTIHIAVVDPGVGTKRRPMAAKIGDYFFVGPDNGIFTAPLLRAEGEGKAIECVELNQPEYWLENVSHVFHGRDIFAPVAAHLANGVALQNLGIPIQNPVLLNLPQAQIFENQILGEITDVDHFGNLSTNIPGNWLSKYSPGNLTFCLGDVIIHGLNKTFGERPEGEWVAFIDSDNYLALAIVNGNAASKAQCGAGTPIIVKIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N579</accession>
    <name>E8N579_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559975.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63593">
        <property type="protein sequence ID" value="BAJ63593"/>
        <property type="gene ID" value="ANT_15650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15650"/>
    <dbReference type="HOGENOM" id="CLU_1529506_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="175" mass="18488" checksum="3099DCB016E6EC4B" modified="2011-04-05" version="1">MSENQAQEKTGVSPIEVHGVEKRVIGDRVIIRQGVVQSLEANEVTIRQGATLISKATNISVSNSSVAISHSQEASFSSSKSGITIVNGNANFDQSGAKVLLVNGNASLDQSGNILLAAKEVQGTNINTVFFFGKNVHGNVQTAFGAKESILFGLIAGFVSGTFLVLYKLFFGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B3</accession>
    <name>E8N5B3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63627">
        <property type="protein sequence ID" value="BAJ63627"/>
        <property type="gene ID" value="ANT_16010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16010"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_1_1_0"/>
    <dbReference type="OMA" id="SEMPFGW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="302"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="40773" checksum="5D9D496EEB6EB538" modified="2011-04-05" version="1">MDSRLYWIGFNMVRGVGAVRFRTLLNHFGSLEIAWNAPQEALKEAGLSPKSIQHLQHLREEPNFFKRLSDYLEKHQICYVLWDDPEYPTLLKQIDQPPPVLYYKGDLLPQDEIAVAIVGTRKMTTYGRQVTEEVASFLARNGVCVVSGLARGVDAVAHEVALKEGGRTFAVLGCGLDRIYPPEHSKLAEKIIQQGALISDYAPGTPPDAVNFPPRNRIISGLSLATVVVEAGEESGALITATFAVEQGREVFAVPGNIHASQSKGTNRLIQQGAIPLLSAEEILEDLHLSRVSEKQTAKKVLPADPLEEKILKALEQQPLHIDEISIAIDLPVEQVSAILTFMELKGLVRHLGTMIYASLYDSSLLKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D1</accession>
    <name>E8N5D1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mtnA</name>
        <name evidence="3" type="ordered locus">ANT_16190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560025.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63645">
        <property type="protein sequence ID" value="BAJ63645"/>
        <property type="gene ID" value="ANT_16190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16190"/>
    <dbReference type="eggNOG" id="COG0182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_0"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="1290468at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="346" mass="38416" checksum="60329C83AE1DD95D" modified="2011-04-05" version="1">MRSIEWDETKKVVRMIDQRCLPQRLEMVECVDYHEVANAIRDMVIRGAPAIGVAGAMGMALAAIHSKYNDWEGFRRYLDEADKVLRASRPTAVNLFWALNRIQTILQRPIEDIEKLKKLILAEALRIAEEDIAINYQISLFGSELIQNGDVILHHCNTGALATVDWGTALGCIRMAHQQGKHIHVLVDETRPRLQGARLTAWELEQYGISYEIIVDGAAGYFLRTGKVQKVFFGADRIAANGDVANKIGTYMLALAAHSNGVPVYCAAPISTVDLSIPAGESIPIEERSADEVLDIQYKGENVVPKGAKARNPAFDVTPHFLLTAIITEKGVVYPPFEENLRQILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D4</accession>
    <name>E8N5D4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560028.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63648">
        <property type="protein sequence ID" value="BAJ63648"/>
        <property type="gene ID" value="ANT_16220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16220"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_0"/>
    <dbReference type="OMA" id="PNGEKWA"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="17"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="565" mass="66442" checksum="CB0FE9B3E76094F5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H0</accession>
    <name>E8N5H0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase</fullName>
            <ecNumber evidence="3">6.2.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.13" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16580"/>
    <dbReference type="EnsemblBacteria" id="BAJ63684">
        <property type="protein sequence ID" value="BAJ63684"/>
        <property type="gene ID" value="ANT_16580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16580"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_3_1_0"/>
    <dbReference type="OMA" id="ASHTGKL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="492"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="703" mass="74881" checksum="650C114629FC3D28" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H6</accession>
    <name>E8N5H6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ftsY</name>
        <name evidence="7" type="ordered locus">ANT_16640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560069.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16640"/>
    <dbReference type="EnsemblBacteria" id="BAJ63690">
        <property type="protein sequence ID" value="BAJ63690"/>
        <property type="gene ID" value="ANT_16640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16640"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_0"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="306" mass="33151" checksum="DF35FAACCCEA29B2" modified="2011-04-05" version="1">MADLFSKWKNGLEKTRKAAFGRIATLFGATQINTETWEELEAILVQADLGIETTEEIIQALKQHVVQEGLTRTEELQHALREVLIQRLDPTPVVDFSYQKPAIILLVGVNGSGKTTTAAKLGWQFSRAGKTVLLAAADTFRAAAVDQLQVWGERLGLPVIAGQPNADPAAVAFDAIQSAISKKIDIVLVDTAGRLHTRYNLMEELKKIHRVVGKALPGAPHAVWLVLDATTGQNALQQAKAFKEAVQVTGIILSKLDSSARGGMAFAIQESLGLPILYAGLGEKPEDLQVFDREAFVNGILEKNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K8</accession>
    <name>E8N5K8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">hflX</name>
        <name evidence="10" type="ordered locus">ANT_16960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560101.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63722">
        <property type="protein sequence ID" value="BAJ63722"/>
        <property type="gene ID" value="ANT_16960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16960"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_1_0_0"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="219"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="178"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="225"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="250"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="338"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="451" mass="50247" checksum="2C02C3B42D32D5F2" modified="2011-04-05" version="1">MAKKVPEPTVPPRERAFLVGVELRNEPSLLPLEDSLEELALLAQTAGLEVVGQTTQKLDAPHPDTYIGSGKIEEIKILVEETLAQVVLFDNELSPRHLRELEERLGPHVRILDRTALILDIFAQHAHTREGILQVELAQYEYRLPRLTRAWTHLARQAGGGGGRTGSMGGVGLRGPGETQLEVDRREIRKRIATLKAELEKVRAHRMRYRAQRQRSQIPVVALVGYTNAGKSTLLNRLANAEVYVADQLFATLDPTTRRVELPGGHLALFTDTVGFIQKLPTQLVAAFRATLEEIAEADLLLHVVDITHPNAFEQAQAVHATLKEIQADHIPVITLLNKIDRLPDPKAAEEAIAYFSGSVLAISALKGMGINEMLTLVNQELFETYQPVKVRIPYQEGNLISLFHDQGQVKRIEHTRGGVLIDGNLPGRLLARFQPFLYTDDKLSQKEETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5M4</accession>
    <name>E8N5M4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-xylose ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_17120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63738">
        <property type="protein sequence ID" value="BAJ63738"/>
        <property type="gene ID" value="ANT_17120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17120"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OMA" id="AKREIYQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="271"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="519" mass="57665" checksum="899894771E62C903" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N1</accession>
    <name>E8N5N1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560123.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63745">
        <property type="protein sequence ID" value="BAJ63745"/>
        <property type="gene ID" value="ANT_17190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17190"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_5_0_0"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="126" mass="14186" checksum="F6826BA1DEC1BE15" modified="2011-04-05" version="1">MTIRIDVWLYGELAKYGGEQAKPGFANLYLELPEGATVADLLKKIQMPTEERGITFINGLLSAMPGVQPDLSHILQDGDRVAFFHLRSMWPFQYRHGASMIGELAQELSSREDKGIHHDYRHDSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N6</accession>
    <name>E8N5N6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63750">
        <property type="protein sequence ID" value="BAJ63750"/>
        <property type="gene ID" value="ANT_17240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17240"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709118_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="389" mass="41827" checksum="FE59C33F5A183FFF" modified="2011-04-05" version="1">MWYNASSREYPLNLVKETMTGENQTTQTKICPTCGTRLSSNATRCTVCGTVLVDAEGKTGKDRTVPEISLSLPALLGLIVLLLAVGAGTVYAVFQFTQPAPQSVSAPTLTPSITPTHTMTPTPSPTATLEPTATERPPFEYKVAPLDTCISIASTFNVSVQSIIILNKLPAACDNLVVGQTLLIPYPTVTPTPLPTNTLDPTQQAEAACEKLEYTVTETDTLSKISANYGVSAQAIRDYNGLPGDIIFPGQKLIIPLCERGPKPTPTPTPIPPYPAPNLLLPTDGASFLSLNDIITLQWASVGELRPNEAYAVSLIDATDSSKGKFVAYVTETKYIVPEQLRPTDGKLHIFRWSVLPVRQTGTNKETNEPIWEPAGAVSAERVFAWASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q0</accession>
    <name>E8N5Q0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63764">
        <property type="protein sequence ID" value="BAJ63764"/>
        <property type="gene ID" value="ANT_17380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17380"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_5_0"/>
    <dbReference type="OMA" id="PREEIRI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin_C" evidence="3">
        <location>
            <begin position="79"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="241" mass="26092" checksum="D6F8CFE80C1B504C" modified="2011-04-05" version="1">MAIVTMPFGFEVGKRQKNAREGLMKLQPHADTLITVPNDQLLKIASPNLPLDMAFRLADDVLRQGIQGISELITQPGLINVDFAHIRQVMQHGGGSLMAIGIGEGNSKALKAVEHALHHPLLDSISLDSATGIIANFTGGADLTFMELMEAMQFLQEQTHGKAEIIPGVITDERMRDRAQVILIVTGVGATPVEALRSPLPVQQNMPVHPPAQAVEVSTTIPAEISATDLDLPAFMRRRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W4</accession>
    <name>E8N5W4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="7" type="ordered locus">ANT_18020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560206.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18020"/>
    <dbReference type="EnsemblBacteria" id="BAJ63828">
        <property type="protein sequence ID" value="BAJ63828"/>
        <property type="gene ID" value="ANT_18020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18020"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_0"/>
    <dbReference type="OMA" id="IQKYFRD"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="38201" checksum="7BC2A5188CF51ED4" modified="2011-04-05" version="1">MIRSVYYTNHHIIPQTNLSIEEIHRALQDPEGLLWVCLSAPTEEELQTILGNLFHFHPLAIEDCTSHGYQVSKIDEFRDYLFIVMHALPSGKFWEISEPIEVDIFLGKNYVVSVTHESYVSPIETVWKHLEKDERLITRGSDFLCHAILDHLVDDYLPVLDEIDEQIEFLEDQVLQSPTPDVLSKTLEMKHALMSMRRLVAPQREIMNRLSRDEFPMIDQQSKIYFRDIYDHLVRLQDLSESLRDIVTGILDIYLNSTSLRLNEIMKALTIVSTIFLPLSFVAGVYGMNFIHMPELGWRYGYLMVWVIFFLIASGMILFFKKRNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W9</accession>
    <name>E8N5W9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiB</name>
        <name evidence="3" type="ordered locus">ANT_18070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560211.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63833">
        <property type="protein sequence ID" value="BAJ63833"/>
        <property type="gene ID" value="ANT_18070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18070"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_0"/>
    <dbReference type="OMA" id="ETHHANQ"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="155" mass="16798" checksum="905E268F727A9D01" modified="2011-04-05" version="1">MRVAVACDHGGFPLKATVLRVVQEEGHEPLDLGAYDAQSSDYPDYALKIGEAILSGKADRGILLCGSGVGACIAANKIQGVYAGVCHDTYSAHQGVEHDDMNVLCLGARIVGEELAKELVRAFLRAKFSQEERHVRRVQKVRKIEQKGAVQPKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N643</accession>
    <name>E8N643_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">adh</name>
        <name evidence="2" type="ordered locus">ANT_18810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560284.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18810"/>
    <dbReference type="EnsemblBacteria" id="BAJ63907">
        <property type="protein sequence ID" value="BAJ63907"/>
        <property type="gene ID" value="ANT_18810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18810"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_7_0"/>
    <dbReference type="OMA" id="GIPWLGH"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="33"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="37828" checksum="3B8095CE51A96948" modified="2011-04-05" version="1">MRAMQITRITSVLDDPEPLQFTTNKPIPACQKDEVLIRVSACGVCHTEIDEIEGRTPPSHFPMTPGHQVVGQVVEVGDARNAHLLGKRVGVAWIYSSCGSCEFCLSGRENLCPEFRATGRDANGGYAEYMNVLADYVHPIPDHLDDVSAAPLLCAGAVGYRSLWLSGIANHQNLGLVGFGASGHLVLKLVRFLYPHTQVFVFSRTPAEQDFARELGATWAGGIEDAPTERLHAAIDTTPVWTPPVQTLRHLLPGGRLVMNAIRKENSDLSIWSSVQYERDLWMEKEIKSVANVTRNDVREFLKLASQIPILPEVEIYSLEEANMALKALKQRKIRGAKVLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>E8N656</accession>
    <name>E8N656_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">lexA</name>
        <name evidence="16" type="ordered locus">ANT_18940</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18940"/>
    <dbReference type="EnsemblBacteria" id="BAJ63920">
        <property type="protein sequence ID" value="BAJ63920"/>
        <property type="gene ID" value="ANT_18940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18940"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_45_2_0"/>
    <dbReference type="OMA" id="EGVFCGL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="106"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAJ63920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="241" mass="27373" checksum="0AA4AB25183FEA07" modified="2011-04-05" version="1">MMMARKSEGLGERPKKILDFLIKYQEKHGYPPSIREIGNHINVDSTSLVDYYLNQLQEAGFIERGGRISRSIRVLRTLDGQVPFMQTLNTVKTAMERATHELLSIPVIGRIGASYPIPMPESDVPYFDSMSTVEVAQSLLPKEKLSDLFALEVEGDSMIDAMVNDGDIVILKRAEVANNGDMVAVWLTRDNETTLKYYYNERNGFVRLQPANRTMQPIIRPEKEVQVRGKVVLVLRQYASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N679</accession>
    <name>E8N679_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19170"/>
    <dbReference type="EnsemblBacteria" id="BAJ63943">
        <property type="protein sequence ID" value="BAJ63943"/>
        <property type="gene ID" value="ANT_19170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19170"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_501219_0_0_0"/>
    <dbReference type="OrthoDB" id="2201043at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="543" mass="62750" checksum="C53021CECD0BCD45" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6E1</accession>
    <name>E8N6E1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_19790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560378.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64005">
        <property type="protein sequence ID" value="BAJ64005"/>
        <property type="gene ID" value="ANT_19790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19790"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_362043_0_0_0"/>
    <dbReference type="OMA" id="PADPIYF"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="340"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="751" mass="86504" checksum="AEF1DB738C9E6B99" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6F6</accession>
    <name>E8N6F6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_MA_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560391.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19940"/>
    <dbReference type="EnsemblBacteria" id="BAJ64020">
        <property type="protein sequence ID" value="BAJ64020"/>
        <property type="gene ID" value="ANT_19940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19940"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691958_0_0_0"/>
    <dbReference type="OMA" id="YWYRITN"/>
    <dbReference type="OrthoDB" id="1514411at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039568">
        <property type="entry name" value="Peptidase_MA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13485">
        <property type="entry name" value="Peptidase_MA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_MA_2" evidence="2">
        <location>
            <begin position="176"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="398" mass="45222" checksum="9275CD8BFE6C426D" modified="2011-04-05" version="1">MKENRLFHGKSIFLVVLLLILIKANPGWAQSGITFENVAAIPEFGKSITFQATIRSETPLESVLLVLQGNQKQPEIFPMSLSETGEVIYRLETSARKIRPFTRLEYQFRVRLQNGREILSPMYSVRYEDTRFPWETTTNDSITVYWYERAPDFGQTALNVAEEGLRSAQRLLPVPLQSPITIYIYNSSQDIREVLQSSSPWIAGHAAPEDNLILVSIVQGLEERLELERQIPHEIMHILQLQYLGEKISQQPIWLIEGLASVSELYPNPNYLQALEQSAIENRLLPLTSLCTAFPRDASGAFLAYAESDSFVRYLYRSFGATGLQNLMTQYHDGMGCEQGFEKAFTYSLTQMESRWKQEELRVSPEALVFRNLSPYLVIILVLFGATAAAVILAKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF3</accession>
    <name>E8MXF3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560405.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20080"/>
    <dbReference type="EnsemblBacteria" id="BAJ64034">
        <property type="protein sequence ID" value="BAJ64034"/>
        <property type="gene ID" value="ANT_20080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20080"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_565801_0_0_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="482" mass="52707" checksum="60B00699C487C43A" modified="2011-04-05" version="1">MTGKSHTHGFRIVLLAMILSGLSLISNLPVYGMLPPSELNQIEQPAGPVDQVLEASHESIPLSEWPQVQRDPQHTGYYPENLGTNFQVVWRHAFQPEKVFPQVQAIISGGKVFVGTEMGNMYAFNATTGEQAWKTSIGSPILNSVAVDGGKVFFGALDGAVYALNATNGAQVWKNQLSTFQGFSTAPVVADGKVMLGGRNGIFYALDPNSGQVLWSYPVGSPILQTAAWNNGKVYFGAMDMRVYAINSASGTLAWKSAQLPGMTFKDYWPLVLNGMVYIRPMGYGYVGISEIPTANQVLDPTIQQNILADYAANPQNYSPTLFRLYETSGEQAPMVIHYNFQTMNGATPPPCVDRDGYLIMPSWTPQGGYSSGWSRLNPTTRILVDALVEVGSNEGKGNQDETMNVTCSKNLILAMHIEEENANFTGYYNLDTRQWTLIPAGASNRQMQNNTQGGGGNPASIANGWVYHITYYELVARRTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG8</accession>
    <name>E8MXG8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560419.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64049">
        <property type="protein sequence ID" value="BAJ64049"/>
        <property type="gene ID" value="ANT_20230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20230"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_0_0"/>
    <dbReference type="OMA" id="PAYNCAS"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="410" mass="46931" checksum="E9940CA33650ABE5" modified="2011-04-05" version="1">MPRVSIIIPTYNSAKFLQATLESVFQQTFQEYEIIVIDDGSTDNTREVLSPYKSRIRYLYQENQERSVARNYGLSLAQGELIAFLDSDDLWLPHKLERQVQVMNEHPEVVLVFSQALYIDSEGTPTAFCGEWLDGKPANDIEIRSFFEDFAQGNVVYGGGSTALVRKEVIEKAGGFDPAITHGEDWDLWWRISTLGPFAYIPEPLIYYRVFGWKKLLQRQSTERALQEHLYVIEKNLGHLPPEAKQRLYPLAQCHMTVLAALGSYQLEEFERAQKFLKKVGEIDPSWTSPERILWLAVDRAKIIERDTGSYEEAIAFIRNMFQHLPSEIQMPASSLQKAIGWLYISGAFEQHARGNLKKVRQYLLQGIPRVPQALSNRGVVSMIIQALLGRSFTHSLRNVMGKKVNQPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX2</accession>
    <name>E8MXX2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">parA</name>
        <name evidence="2" type="ordered locus">ANT_21770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21770"/>
    <dbReference type="EnsemblBacteria" id="BAJ64203">
        <property type="protein sequence ID" value="BAJ64203"/>
        <property type="gene ID" value="ANT_21770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21770"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_0"/>
    <dbReference type="OMA" id="CIFSMNE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="30264" checksum="535AA2D06171F731" modified="2011-04-05" version="1">MSREMKKARVIAVANQKGGVGKTTTVINLAHWFALHGRRVLVLDLDGQGHIAPGLRLPGGDHLYRFLVHEEEVSNVTVKARENLDIIPNDHTGELAKEHVKQANFREYILDTALEEARERYDLIFLDTPPGADVLHVLALVASDFLIVPANMDFYALNGVGQILKTVRNLKRYPGVTPPVLVGVLPTLFDKLTNETLNNLQSLQQSLGENYILPPIPRDTRLREASSHGQTIWEYAPACQGASGYPGNGEKQCNSSGKVGGYLHIAEILHDIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY6</accession>
    <name>E8MXY6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560586.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64217">
        <property type="protein sequence ID" value="BAJ64217"/>
        <property type="gene ID" value="ANT_21910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21910"/>
    <dbReference type="HOGENOM" id="CLU_1682994_0_0_0"/>
    <dbReference type="OrthoDB" id="2132226at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="156" mass="17890" checksum="A02F666638AFFC91" modified="2011-04-05" version="1">MATLPVFIPLSEAARKYGLEEAHLRQLIEKGKIRAGVVAGEMVVSEEEVRGEAIQEKGLRKEDLPEYQQYSHLESIEIEFGEAARKYRIPPATLHGWVTRKIVKIIRRQGKKVVLKEQDVAYCAKIYEMRKGQGKWLFDKDGLPYKYKSKSNSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY28</accession>
    <name>E8MY28_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560627.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22330"/>
    <dbReference type="EnsemblBacteria" id="BAJ64259">
        <property type="protein sequence ID" value="BAJ64259"/>
        <property type="gene ID" value="ANT_22330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22330"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_0"/>
    <dbReference type="OMA" id="RFCCAFQ"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="203"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="345"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="608" mass="69876" checksum="888A2EEA1A3BAAF6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY31</accession>
    <name>E8MY31_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_22360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64262">
        <property type="protein sequence ID" value="BAJ64262"/>
        <property type="gene ID" value="ANT_22360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22360"/>
    <dbReference type="HOGENOM" id="CLU_2153053_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="111" mass="13144" checksum="DC8078A3229AD1FC" modified="2011-04-05" version="1">MCRCNIKEKECANMRERMVRAQLLLQPDLHRRLRKIAEQENRSISDVTRDLLEIALNQREKLQATKLEQVRALQQIAERILQERVGKPLEIDVAQLIVEEREERTREIGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY57</accession>
    <name>E8MY57_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_22620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560656.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64288">
        <property type="protein sequence ID" value="BAJ64288"/>
        <property type="gene ID" value="ANT_22620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22620"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_2_0"/>
    <dbReference type="OMA" id="IIIAMPS"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="297"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="635" mass="69954" checksum="CCB61DC8BF975AF4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA6</accession>
    <name>E8MYA6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA glycosylase</fullName>
            <ecNumber evidence="7">3.2.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_00170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558449.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62051">
        <property type="protein sequence ID" value="BAJ62051"/>
        <property type="gene ID" value="ANT_00170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00170"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_0"/>
    <dbReference type="OMA" id="GPQGWWP"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="44"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="237" mass="26423" checksum="1647ED5275B182F9" modified="2011-04-05" version="1">MSASPDPRHLERAQTVYRLLEAAYGIPEWRNPLPPLDELVSTILSQNTNDRNRDLAYQRLRERFPTWEDVRDAPLEQVIEAIRPAGLANQKGARLQEVLRQITAERGGLDLSFLQDLPAEEARTWLLRFKGVGVKTASIVLLFSLNKPAFPVDTHVHRVSGRIGLRPPQMSAEDAHAYLAQVFTPEQYAAGHLNLIRLGREVCHARKPACPRCPLRAVCEWATQGGAGRASTGQTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB7</accession>
    <name>E8MYB7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558460.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00280"/>
    <dbReference type="EnsemblBacteria" id="BAJ62062">
        <property type="protein sequence ID" value="BAJ62062"/>
        <property type="gene ID" value="ANT_00280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00280"/>
    <dbReference type="HOGENOM" id="CLU_511585_0_0_0"/>
    <dbReference type="OMA" id="MELVILQ"/>
    <dbReference type="OrthoDB" id="12942at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="532" mass="56909" checksum="9582E4FC05F69F94" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN7</accession>
    <name>E8MYN7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="10" type="ordered locus">ANT_23470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560739.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23470"/>
    <dbReference type="EnsemblBacteria" id="BAJ64373">
        <property type="protein sequence ID" value="BAJ64373"/>
        <property type="gene ID" value="ANT_23470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23470"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108412_0_0_0"/>
    <dbReference type="OMA" id="YRFTTYE"/>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="48"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="157" mass="18094" checksum="0AC3D26BD726C08B" modified="2011-04-05" version="1">MRCPYCQNEDTKVLDTTHDNRGIVRRRRECLSCHQRFTTLERPLLATPLIIKKDGTREEFDREKLLRGIRIACAKRPVPASAIERLVGEIETTLQRMGKAEVNSRVIGDMVIEGLRGLDHIAYIRYAIVYLQLGDLHAIRNEIDRLLSEESNNVKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP9</accession>
    <name>E8MYP9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_23590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560751.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64385">
        <property type="protein sequence ID" value="BAJ64385"/>
        <property type="gene ID" value="ANT_23590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23590"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="OMA" id="ITHIGIR"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="352" mass="39299" checksum="2F536E9BC796287E" modified="2011-04-05" version="1">MLEVREIYKQYEGKPLLQGVSFTLSEGETLALLGPSGSGKSTLLRIIAGLEESESGQILWNGEDLSGIPAHRREFGLMFQDYALFPHLNVFENVAFGLRMAGLPREEIHRRTAEALSLVNMEAFSRRRVTDLSGGEQQRVALARALAPRPRLLMLDEPLGALDRTLREELLEDLRHLLHTTRIPAIYVTHDQEEAFALADRLILLHEGKIEQEGTPQDVYSQPVSLWAARFLGQSNVLPGRVIQSDPLLVETPEGRLGGVSADGRFLSPGEAVAVLLQWVGVELLAPDDSRALFSAVVEDVTFRGDSFRVELLTRHHRRLLFHISHSVRVGERVGVTLEPQAVRVYPESEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW3</accession>
    <name>E8MYW3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560804.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64449">
        <property type="protein sequence ID" value="BAJ64449"/>
        <property type="gene ID" value="ANT_24230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24230"/>
    <dbReference type="HOGENOM" id="CLU_2566372_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="81" mass="9627" checksum="92D78B7E29352376" modified="2011-04-05" version="1">MNLYRAQIILEKQQHEQLSQIAHEEGKSISEVARELIRLALRERQRRQMEMAAQILQEDYQNDPELTAFTALDGEDWDETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX0</accession>
    <name>E8MYX0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560811.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64456">
        <property type="protein sequence ID" value="BAJ64456"/>
        <property type="gene ID" value="ANT_24300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24300"/>
    <dbReference type="HOGENOM" id="CLU_1412594_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="195" mass="21534" checksum="896F6929EDD51309" modified="2011-04-05" version="1">MRFANRVVLQGYLEIERAEQIALDETSELSAPVLHGWLWTDAAGLERHRVVLADKPALGLLEMLRKFNPTEGGSALVSINGSRFEVAHLDGKPFVAVEGRLLDGVVDVKHVTLLSTPDAGLLRLLTDHRLREIVYAWEEIREADRALMYRIVREIRQMRDGEPLSLTALGQGAPDGAWGGLTSTPPAPRREAPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ26</accession>
    <name>E8MZ26_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein ANT_01350</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558567.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01350"/>
    <dbReference type="EnsemblBacteria" id="BAJ62169">
        <property type="protein sequence ID" value="BAJ62169"/>
        <property type="gene ID" value="ANT_01350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01350"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_1_0_0"/>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="OrthoDB" id="1883809at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="114" mass="11893" checksum="713D1CA664BB0F02" modified="2011-04-05" version="1">MAKGFNRPPVGGGGNMMAQLKKLQEQMEQAQARLAEETVTGTSGGGAIKVVMTGDQHCKAVEIAPELLQEVDADMLQDMLLAAINQALELSRQKQEEMLGPLAGGLGGLGGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ53</accession>
    <name>E8MZ53_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
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        <property type="protein sequence ID" value="BAJ62196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
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    <dbReference type="EnsemblBacteria" id="BAJ62196">
        <property type="protein sequence ID" value="BAJ62196"/>
        <property type="gene ID" value="ANT_01620"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="163" mass="18700" checksum="9C1DC52AF2F57715" modified="2011-04-05" version="1">MLSKRLLEEMNTQIKLELYSAYLYLAMAAHFEENNWGGFAKWMAMQAREEQEHALKFFEYIHDRGGKVTLQAIDAPPSAFGTHEEIFAEVLKHEQSVTARINLLYSIAVEDKDYASQEFLNWFVKEQVEEEKNAAQVLEWLKMAGGAVPALFQINALLAQRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ62</accession>
    <name>E8MZ62_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ62205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558603.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01710"/>
    <dbReference type="EnsemblBacteria" id="BAJ62205">
        <property type="protein sequence ID" value="BAJ62205"/>
        <property type="gene ID" value="ANT_01710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01710"/>
    <dbReference type="eggNOG" id="COG3322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_404229_0_0_0"/>
    <dbReference type="OMA" id="FMIEHND"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007892">
        <property type="entry name" value="CHASE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
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        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
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        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="CHASE4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="297"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="394"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="535"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="680" mass="78162" checksum="296F857BAFA14366" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZB2</accession>
    <name>E8MZB2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558653.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62255">
        <property type="protein sequence ID" value="BAJ62255"/>
        <property type="gene ID" value="ANT_02210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02210"/>
    <dbReference type="eggNOG" id="ENOG5034217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2056469_0_0_0"/>
    <dbReference type="OrthoDB" id="2155603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="119" mass="13614" checksum="1D2678F0176ACFF1" modified="2011-04-05" version="1">MQKKLLSGIIAIGIAFVITITVLAGGMNYAYAWETLGGARWNGYIQIQACYNDNGNHAKQGYHRFTRQAGPPLDTGRMYTSQATSPQDCTIRSRQDSVWDSPLWGDQYTTRYFYDFVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE8</accession>
    <name>E8MZE8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560851.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64496">
        <property type="protein sequence ID" value="BAJ64496"/>
        <property type="gene ID" value="ANT_24700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24700"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_0"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="1">
        <location>
            <begin position="271"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="356" mass="39281" checksum="0A633F1C697230A0" modified="2011-04-05" version="1">MKLGIIGLPQSGKTTLFNALTRGNQPTGMASGKLEVHTAVVDVPDPRVDRLAAMFKPKKTIYAKVTYADIAGLEGSAAKTGISGALLNQLTQMDGFIQVVRCFEDENVPHPAGSVDPLRDLASMESELILNDLISVERKLERLNDERKKGGGRDKATIDREIALFERFHEALVAEKPLRDVDIDAEEEKMLSSFGFLSRKPMLVVLNVSEGQQPPAIDYPHRHSKVVALQCRLEMEIAQLPPEEAAAFLQEYGIDEPSLNKMIRLSYDLLGLQSFFTVGPDECRAWTVRKGATAPEAAGVIHSDLQKGFIRAEVMTYDDLIALGGVNEVKSHGKLRLEGKEYIVQDGDILNIRFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ6</accession>
    <name>E8MZJ6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25180"/>
    <dbReference type="EnsemblBacteria" id="BAJ64544">
        <property type="protein sequence ID" value="BAJ64544"/>
        <property type="gene ID" value="ANT_25180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25180"/>
    <dbReference type="eggNOG" id="ENOG503470Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275521_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="216" mass="23706" checksum="807FD504191F3957" modified="2011-04-05" version="1">MDSTQPLSENSPKSSFSLASLKIAPAFWTIASILSLIVNLILVIVLLVLATQLFTLKRVIQDQVLGGLYRNFILMDQAHIRTTIPVSTEVPARFTLPLETETVVVLTEDTFLQGATVRELTTGGLTIRNAPADIVLPAGTRLPVALNLDVPVDQMIPVNLNVQVDIPLSQTELHQPFVGLQEVVRPYYKMLDDLPDSWGELLCRSAAGSLCDSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK9</accession>
    <name>E8MZK9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560912.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64557">
        <property type="protein sequence ID" value="BAJ64557"/>
        <property type="gene ID" value="ANT_25310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25310"/>
    <dbReference type="eggNOG" id="COG1996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825390_0_0_0"/>
    <dbReference type="OrthoDB" id="1145242at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="343" mass="38006" checksum="7735BAFCD22E8606" modified="2011-04-05" version="1">MSTQALHGLTCPRCGGTVPVPEGQRLVICPYCDLRSVVSGEGGVRRYQVPLRVEREAAEKAFRAFLSSSPSIASGVTREAQLSEIFLVYLPFWSAWGKGVAWAFGQQRVGSGDNARYEPRERRATAELIWTQVACDVGEFGVQRIELKGCPLEPFDPEALHRKGMVFEPVGSPQQALQEAQQSFENHIQGKVSLSRTAQVFTRILNPRLGLVYYPIWVVRYLHKQRAYQVVIDGYHGNVLYGKAPGNLLMRALTLVGGMAFGAFLAVDVPALIVSLSGDEDILGLALIALGIGLALMFGGYQRFRHGEHYEYHRLKGEPSALLELGENTDLSQFVKALREWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN7</accession>
    <name>E8MZN7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_25590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560940.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64585">
        <property type="protein sequence ID" value="BAJ64585"/>
        <property type="gene ID" value="ANT_25590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25590"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_5_1_0"/>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="129"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="509" mass="58243" checksum="4F8935BA7C85E258" modified="2011-04-05" version="1">MKVFHIIPQPAFMSLQPGEFQFTAETALVAGAGTEEVTALAHLQLAQAGLDLPLGEEGAQGKVIFELVPDLNLPNSEGYSLKITPEEIRIRAQETAGLFYGLQTLRQMLLISPQDFRLPCVDIEDYPRFRWRGAMLDVCRHFMPKSFVMKFIDLLALHKLNTFHWHLTDDQGWRIEIKRYPRLTEVGSKRKETLIGRPSWTDPNEDRFDGIPHGGFYTQEEIREVVEYARQRFVNIVPEIEMPGHSTAAIAAYPELGNTGRQIEVATRWGIFEDIFNVEESTFRFLQNVLDEVMELFPSPFIHIGGDEVPKQQWRESPRVQQRMRELGIDSEEELQSYFTRRMDAFLFARGRRMIGWDEILEGGLAPGAAVMSWRGEAGGIAAAQAGHEVVMAPNTYTYLDYYQGPPEREPLAIGGFVPLEKVYSYEPIPAELPAEKAHFILGAQAQLWTEYMPTPEHVEYMAFPRLCALSEVVWSRPDQKDFEGFKERLRSHVARLERLGVNYHPLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP5</accession>
    <name>E8MZP5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_25670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560948.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64593">
        <property type="protein sequence ID" value="BAJ64593"/>
        <property type="gene ID" value="ANT_25670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25670"/>
    <dbReference type="eggNOG" id="ENOG503366P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494051_0_0_0"/>
    <dbReference type="OMA" id="THASIEW"/>
    <dbReference type="OrthoDB" id="1861185at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="3">
        <location>
            <begin position="403"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="551" mass="61797" checksum="6134ED39163A4343" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS5</accession>
    <name>E8MZS5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4HBT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25970"/>
    <dbReference type="EnsemblBacteria" id="BAJ64623">
        <property type="protein sequence ID" value="BAJ64623"/>
        <property type="gene ID" value="ANT_25970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25970"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_6_2_0"/>
    <dbReference type="OMA" id="ICAQACM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="60"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="166" mass="18671" checksum="2CE734185C259BD4" modified="2011-04-05" version="1">MFQERKTAMTAKRLKQPNSRHCFVCGVENPVGLQLKIYQIEEGVIETTYTAPEHFQGYPGVLHGGIIATLLDEISGRAHMGDPSQPRFMYTGKLEVIYRRNVPIGQPLRIVGKKLENRGRAAQGWAGIYDEKGNLLAEGTTLLFDIPPHLLPLKDLEELGWKVYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU6</accession>
    <name>E8MZU6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative basic membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_02470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558678.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02470"/>
    <dbReference type="EnsemblBacteria" id="BAJ62281">
        <property type="protein sequence ID" value="BAJ62281"/>
        <property type="gene ID" value="ANT_02470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02470"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_1_1_0"/>
    <dbReference type="OMA" id="TYMPESE"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005674677" evidence="3">
        <location>
            <begin position="24"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="31"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="330" mass="35945" checksum="9F0B7AAF01566537" modified="2011-04-05" version="1">MKRVLFVVLLLALVLAACTPATPTQPAKTYKLAAIFPGVINDSDYNTLGYMGAEAVKKDLGIEMAYSETVAVPDIDRVMREYIDQGYNIIWTHGGQYVNQTIELAKQFPDVVFIAEGDAKPAEMPANVWFIDRNFHIGFYGVGALAARITQTGKIGYIGGLTLPFSYAEVHAMQQAIKDSGKNVELKAVWAGDFNDPTKARQVADTMIAEGYDVLVGSLNNGMLGVFEAAKATTDKKILVTAKYTDKTSIAPDNYVTSLLYDFVKPMKDIVGKIQAGEKGGYYPLGFDTGVSLQTPFKNVDPAVEEEMKAVINDLVSGKIQVVKDTSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW6</accession>
    <name>E8MZW6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558698.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02670"/>
    <dbReference type="EnsemblBacteria" id="BAJ62301">
        <property type="protein sequence ID" value="BAJ62301"/>
        <property type="gene ID" value="ANT_02670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02670"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155828_0_0_0"/>
    <dbReference type="OMA" id="HIIADHI"/>
    <dbReference type="OrthoDB" id="1986500at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="124" mass="13839" checksum="DD1427F3A84C62BC" modified="2011-04-05" version="1">MFFVLYVLHDETKLSAVLDAWDEAGVTGVTVLPSTGMGRIIKHGALREDMPLIPSLQALLKEHEEILNRTLFSIVESREVVQRIVENTEKVVGPLADPNTGILAVLPVLEVYGLRSREDHEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N004</accession>
    <name>E8N004_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558736.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03050"/>
    <dbReference type="EnsemblBacteria" id="BAJ62339">
        <property type="protein sequence ID" value="BAJ62339"/>
        <property type="gene ID" value="ANT_03050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03050"/>
    <dbReference type="HOGENOM" id="CLU_703293_0_0_0"/>
    <dbReference type="OrthoDB" id="1303547at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="392" mass="45742" checksum="7AEE6BE664DC31E3" modified="2011-04-05" version="1">MELQELVIAIAEVGKEHPSRPLLHEVEIFRHFFVQGEIDWKNLDQRDGSLTRRETLTRFLLLCAVLDQGPDIEGIRRMLIETTNELYRKEIRFLHKPISFFSEIGVAIDEILARHEAIKNIRARVWAEANRSNPARYNLFMDNASQVLGYAIFRWGVPLSLPYLLEKDRQKENLSGENALLDYLESYDSAERMTQQLKDHSRYGLGKAIGDKASHLFGKWLVSSFRLTRQSGDGWDDFSYEVPYDSNAGRVLWRTGFLLHWADEEDFKKQLVLQSGKGKGNTTYLRVTNLRGMKAVKNVGDNLKEPYEEICLRHLKTHKKRPKNFQIQQIQHIYLWQNRGRGLHAAHFDDGLIFIGTHYCFNHDQPDCQQCPINTLCMGYSSERRLIRDFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N026</accession>
    <name>E8N026_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvN</name>
        <name evidence="10" type="ordered locus">ANT_03270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558758.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03270"/>
    <dbReference type="EnsemblBacteria" id="BAJ62361">
        <property type="protein sequence ID" value="BAJ62361"/>
        <property type="gene ID" value="ANT_03270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03270"/>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_1_3_0"/>
    <dbReference type="OMA" id="EPYGIKE"/>
    <dbReference type="OrthoDB" id="1500398at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19582" checksum="44480B4EAD8D82F7" modified="2011-04-05" version="1">MRHTLVALVEDKPGVLNRVASLFRRRAFNIESLTVGHTEQPGLSRMTIVVDGDDIAIERLIAYLYKLVNVVHVEDLTHVPAVTRDLAMIKVAAPPETRTQVMQVVDVYRARIVDVTSQSLIIEVTGDEEKIESFVEVLRPLGILEMVRTGLLAMSRGGAPLYPPPNGNGNGHHAAASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B7</accession>
    <name>E8N0B7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561020.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26400"/>
    <dbReference type="EnsemblBacteria" id="BAJ64666">
        <property type="protein sequence ID" value="BAJ64666"/>
        <property type="gene ID" value="ANT_26400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26400"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030564_0_0_0"/>
    <dbReference type="OMA" id="NYNSPAF"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228576" evidence="2">
        <location>
            <begin position="28"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="483" mass="53547" checksum="881A17988FE40A36" modified="2011-04-05" version="1">MKTAKQWIFLAMIALFVASLMGCAPQATPTTEVPQPTEPPQVEPTATEVPPTPEPTATEAPQPVTLRYANWNLGTEEENNIQRQLVKAYMEMNPHVTIEFVDMSAEGGWDANLNAYAAKGELPDVFMANNMPLYVKNGWVADLTDLVKDDSDWANVPQVLKDGVTYGDKVLGLPAAQFIMGYFVNKDLFEAANLDAPEYGVAPEDFFAAVTALNNPAKGILGLDEMEFVLGWYPHTVDPNLKWFSFDGTKMNYNSAAFKEAIAKVAELKPYTWQGLTDEQKANFKSQDPWELFLNQEVGVRWEGGWNLPNFVQNATFEWDFVGIPGGTQALVMDIMAVSKTTKNLEEAYKFAKWMTFSSEAYAKEAELAKAAGSAPKMPVAMDDASLALYREFVDKPGVNAALDNLDASLVESLAKIVPGYIQARWEGKPGIDIGEDKDVNMWYMFNFASEGKFKYEDYAAKLEEFANKILADAKAEVEASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I2</accession>
    <name>E8N0I2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561083.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64731">
        <property type="protein sequence ID" value="BAJ64731"/>
        <property type="gene ID" value="ANT_27050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27050"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089258_0_1_0"/>
    <dbReference type="OrthoDB" id="1629615at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="204" mass="23709" checksum="8FD63B9571584AAF" modified="2011-04-05" version="1">MSVRNAILGLLCQRTRYGYEVLQAFQAVAGGRETWDLKPAQVYTTLARLKDSGLVIEEFPDGNEDPAKRRYTITPAGKAELQRWFETPVRTEHQRDEFFLKLMLALATGEADPRRLIYLQRANLFQELHRLTALRMELDPYTSLAHILLLDQAVMHVEADLRWLEMIEARLDEVRKQPIPEPELRPRGRPSKQEKLTTSLKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N4</accession>
    <name>E8N0N4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein ANT_03950</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_03950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558825.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03950"/>
    <dbReference type="EnsemblBacteria" id="BAJ62429">
        <property type="protein sequence ID" value="BAJ62429"/>
        <property type="gene ID" value="ANT_03950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03950"/>
    <dbReference type="eggNOG" id="COG0393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117144_1_1_0"/>
    <dbReference type="OMA" id="ETRNQAM"/>
    <dbReference type="OrthoDB" id="2015368at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="109" mass="11991" checksum="173966CB13151195" modified="2011-04-05" version="1">MDRSMVTTTFGFEGYRIVRYLGVVRGITVRSRSIAGNFVGALETMVGGKITTYTELCEHARQEAFDLLIQHAEQIGANAIIGMHYDATELMESVTEVLAYGTAVVVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N8</accession>
    <name>E8N0N8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tagatose 1,6-diphosphate aldolase</fullName>
            <ecNumber evidence="1">4.1.2.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lacD</name>
        <name evidence="1" type="ordered locus">ANT_03990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.40" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558829.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03990"/>
    <dbReference type="EnsemblBacteria" id="BAJ62433">
        <property type="protein sequence ID" value="BAJ62433"/>
        <property type="gene ID" value="ANT_03990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03990"/>
    <dbReference type="eggNOG" id="COG3684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058971_0_0_0"/>
    <dbReference type="OMA" id="KDITRPS"/>
    <dbReference type="OrthoDB" id="1560751at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009025">
        <property type="term" value="F:tagatose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="315" mass="34539" checksum="2704F67E0B8ECDB7" modified="2011-04-05" version="1">MKALSIAKFRSFQTCASAHGTFTFLALDHRQNLRRANPRFEDNHELSRFKLEVTAELAPFATGVLLDPEVSAAQAIASGALPGTKGLVVALEATGYTGEPAARRSQILPGWSVEKAKRMGASMVKLLVYYHPESPTAQEIEAFVAQTAVECQRYDLALMLEPLSYPLKGERLSGEEKRRVVIETARRLTAIPGVDLLKAELPQATDDLDMGKLADACAELHEASQAPWILLSAAASFETYLQQTAVACRAGASGIAVGRAVWQEAVALDGSDRLDFLRRIARPRLERLSALCLALARPFTEVYSAEAPFDWYRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T1</accession>
    <name>E8N0T1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62476">
        <property type="protein sequence ID" value="BAJ62476"/>
        <property type="gene ID" value="ANT_04420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04420"/>
    <dbReference type="eggNOG" id="COG3870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143974_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010375">
        <property type="entry name" value="CdAMP_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38456">
        <property type="entry name" value="PTHR38456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06153">
        <property type="entry name" value="CdAMP_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="115" mass="12721" checksum="978AE4F5EDA787C6" modified="2011-04-05" version="1">MSAEFPTQPIRLWIAVVQAQDAEIAREAVEKLGLHVERLPSVGGFLGRRNATLIIGVPPEKQEQVEQSLHENCRQRVEFIAIPLESAPLPMPTPTPITVGGATVFTLEVDHYEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T3</accession>
    <name>E8N0T3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558874.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04440"/>
    <dbReference type="EnsemblBacteria" id="BAJ62478">
        <property type="protein sequence ID" value="BAJ62478"/>
        <property type="gene ID" value="ANT_04440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04440"/>
    <dbReference type="eggNOG" id="ENOG50333RW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079270_4_0_0"/>
    <dbReference type="OMA" id="MDFERAF"/>
    <dbReference type="OrthoDB" id="1987468at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025098">
        <property type="entry name" value="DUF4013"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13197">
        <property type="entry name" value="DUF4013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="217" mass="23391" checksum="15398ED55352ADFF" modified="2011-04-05" version="1">MDFAKPFTFVFEDQNWLSKIALVAVISLIPVVGVLVLLGWGLEITRRVIRDELPILPEVDFGKHLGDGFKGFVIGLVYSVPMLVLVILMSVFSAALSNSYNTDFANAVLILLVVCLALFILLYGLVLNLLAPAAYARFAATGSMSAAFQFGEVWRTVTANLGGYVLVVLATILAGFIAGLGSIACVIGVIFTGTYAAAVLYHFYGQAYKQARLNRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V0</accession>
    <name>E8N0V0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_04610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558891.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04610"/>
    <dbReference type="EnsemblBacteria" id="BAJ62495">
        <property type="protein sequence ID" value="BAJ62495"/>
        <property type="gene ID" value="ANT_04610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04610"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="FFMELIS"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="336" mass="37353" checksum="1128877C8A509608" modified="2011-04-05" version="1">MKRSRPNIRDVAALAGVSHQTVSRVINGDERVTEETRQKVEAAILQLGYRPSSLARSMAYGRTFTLAFVALNFTDYTFSSMLDAAESEARQHNYFTLAISAGENSNYAELVNQLFGHQRVDGMIVVGPSLVEHHAELAHEAPVVCITPRRISDLPHTVDSDNRQGGWLATRHLLELGHRNIGMITGPQNQVSVQERMEGYCKALQERGVTSPVEWIVEGDWSATSGYHAFEALYPQGVSAIFAQNDRMAIGCIRAARDHGVNIPEDLSIIGFDDIPLASYFDPPLTTIRQDTAELGRQAARLLLELLKNPQLPPRHTVIPTQLIVRKSTCAFQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N105</accession>
    <name>E8N105_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558946.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05160"/>
    <dbReference type="EnsemblBacteria" id="BAJ62550">
        <property type="protein sequence ID" value="BAJ62550"/>
        <property type="gene ID" value="ANT_05160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05160"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111932_0_0_0"/>
    <dbReference type="OMA" id="KDHQYNA"/>
    <dbReference type="OrthoDB" id="1200636at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="38"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="220" mass="24847" checksum="CFAF5E57FFC47769" modified="2011-04-05" version="1">MEEILSLPIRGMDGAPLTNTFFRQKEEASELAVFFPGRGYTCAMPVLYYPTRLMVQRGADALTIEYNATREAGFDQLDMEERLRRLGNDARNAVEVALTQRKYQRVVLFGKSLGSLVLAWLLVHEPELLHATYVWLTPLVRVPFLREAVRRAKPQSLFIAGDADPLFDSDAMQDLMKQGDFHLLVLSGANHSLEIEGDLEATLKGMSLMLRTLDEFLQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N155</accession>
    <name>E8N155_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_27720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561146.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27720"/>
    <dbReference type="EnsemblBacteria" id="BAJ64798">
        <property type="protein sequence ID" value="BAJ64798"/>
        <property type="gene ID" value="ANT_27720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27720"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_1_0_0"/>
    <dbReference type="OMA" id="FDACAAK"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027155846" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="66"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="355" mass="38567" checksum="A076CBF5D7937DE0" modified="2011-04-05" version="1">MSRKLWSIVSVLIVLALALAACAPAATPTATQPPTQEEKPTATPKVEPTATEIPSPTPTVNPFDPAAVSGDIYTAGSSTVGPLTEAIIEMFVADGFTGQVKNDIIGSGAGFERFCKTGETDISNASRKIKDSEVENCGKLNPARNPIGFLVGLDAIAVVVNPQNDWVENVTKDQLFKLFTSAEKWSDVDPSWPNEPILRYTPGTDSGTFDFFVEVAVQKTGKIEKLDEAKKLVLEAKNLNASEDDNVLVQGVEGNKYAIGYFGYAYYKGEGSKLKVLSIEGIKPSLETAENGTYLLSRPLFIYSDAGIMKSKPQVAAFIRYYLEHVNEVIEEVGYFPASKEAMENNLKLFEEAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1D1</accession>
    <name>E8N1D1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28480"/>
    <dbReference type="EnsemblBacteria" id="BAJ64874">
        <property type="protein sequence ID" value="BAJ64874"/>
        <property type="gene ID" value="ANT_28480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28480"/>
    <dbReference type="eggNOG" id="ENOG502Z9AV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979240_0_0_0"/>
    <dbReference type="OMA" id="FLGTYTE"/>
    <dbReference type="OrthoDB" id="1837319at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015093">
        <property type="entry name" value="DUF1887"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09002">
        <property type="entry name" value="DUF1887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="34207" checksum="EB962274CD591CC2" modified="2011-04-05" version="1">MDISDEVAMILLCLAGEQPIPNLLPARFLQPAQTLIAHTSLDASRKSAQRLAGLIGNTRLFSVGDGYQIARILDAYRREMGEPGDEVVVNVTGGTKPMALAAFELARQRHYPVVYYQTEGPRGRDQKSMLYRYCFNEQGQLCLEEGYPRELPGLITLDDYLKAHLDGYHHNTRETAGKALEDAVAQALKPHVDEIKQSVVPDGVKDQAEIDLLVRCGNQVGIFEIKTGGEGSGKKAVDQLTTIAAREYLGTYAARFMVTQASMEVRYKSLASALRVEVIELKEYRSGRPLSQTDSQNLLTRVSNILPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E6</accession>
    <name>E8N1E6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561234.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64889">
        <property type="protein sequence ID" value="BAJ64889"/>
        <property type="gene ID" value="ANT_28630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28630"/>
    <dbReference type="eggNOG" id="COG5579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124534_0_0_0"/>
    <dbReference type="OMA" id="WFVFPQI"/>
    <dbReference type="OrthoDB" id="1625285at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014937">
        <property type="entry name" value="DUF1810"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036287">
        <property type="entry name" value="Rv1873-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08837">
        <property type="entry name" value="DUF1810"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008546">
        <property type="entry name" value="UCP008546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140736">
        <property type="entry name" value="SSF140736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="146" mass="16668" checksum="9510035143032E6A" modified="2011-04-05" version="1">MTKVSDDPFDLERFVQAQEGVYERALAEIQAGEKRTHWMWFIFPQALGLGFSPMSQRYGIRSLDEARAYLAHPLLGARLRACFEALLALQGRSAHQIFGSPDDWKLRSCATLFALVSPPDSLFHQVLEKYFEGQMDEKTLILMNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F4</accession>
    <name>E8N1F4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561242.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64897">
        <property type="protein sequence ID" value="BAJ64897"/>
        <property type="gene ID" value="ANT_28710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28710"/>
    <dbReference type="HOGENOM" id="CLU_2630400_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="77" mass="8358" checksum="C502549E31C3D68C" modified="2011-04-05" version="1">MSYPSPSGNEPADTAVFRTVVLALAVDICERLKCAHLPARLAKEMKRLPDGRFEVRVPAEYAGEALQLVSAWTGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1J8</accession>
    <name>E8N1J8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon monoxide dehydrogenase medium chain</fullName>
            <ecNumber evidence="2">1.2.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.99.2" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558998.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05690"/>
    <dbReference type="EnsemblBacteria" id="BAJ62603">
        <property type="protein sequence ID" value="BAJ62603"/>
        <property type="gene ID" value="ANT_05690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05690"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_3_0_0"/>
    <dbReference type="OMA" id="NQSEWWR"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="291" mass="31224" checksum="0DAB96FE0398ABBE" modified="2011-04-05" version="1">MKPIPFEYFAPTTVEEALEHLSNLGYGGKVLAGGQSLIPAMNFRMARPGALVDLNGIPELAYIKPTADGGLAIGTMTRDSKVEHSPEVAKRFPLLPEVMPNIAHPQIRNRGTFGGSIAHADPAGQLPAISIVLNANLKVLKKGSERWVKAEEFFLGPFMTVLEPEEMLAEVVLPALPPRTGSSYQQVSRQKGGYSMAAVASVVTLDEAGKCTNARMVMISVGDVPILSAAALRILVGQKPTPEAIAEVAEIAASQEIDPGTDIHATAEYRRHLIRVLVRRSLTTAFERAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M8</accession>
    <name>E8N1M8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na(+)/H(+) antiporter subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mrpE</name>
        <name evidence="9" type="ordered locus">ANT_05990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559028.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05990"/>
    <dbReference type="EnsemblBacteria" id="BAJ62633">
        <property type="protein sequence ID" value="BAJ62633"/>
        <property type="gene ID" value="ANT_05990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05990"/>
    <dbReference type="eggNOG" id="COG1863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086615_3_1_0"/>
    <dbReference type="OMA" id="HAMDIED"/>
    <dbReference type="OrthoDB" id="1987527at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002758">
        <property type="entry name" value="Cation_antiport_E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34584">
        <property type="entry name" value="PTHR34584"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01899">
        <property type="entry name" value="MNHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019239">
        <property type="entry name" value="MrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="157" mass="18136" checksum="E3F55AA6D73078B3" modified="2011-04-05" version="1">MRLFLLNVLLAIAWGALTGNFEPENLIGGFALAYLILWLAFSRRPQTRYFRRFPRAVEFILFMAWEIFLANLRVAVTVLSPRPRLRPAVVGVPLSLKSPAEISLLMNLLTLTPGTLSLDVSSDRTLLFVHTLWLESPEEFIQKIKQDYERRIMELFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T3</accession>
    <name>E8N1T3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559083.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06540"/>
    <dbReference type="EnsemblBacteria" id="BAJ62688">
        <property type="protein sequence ID" value="BAJ62688"/>
        <property type="gene ID" value="ANT_06540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06540"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_21_0_0"/>
    <dbReference type="OMA" id="NGCWISH"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="311" mass="35518" checksum="9A03ACCD875202F1" modified="2011-04-05" version="1">MPPLVSIVTPSFNQAPYLEQTLRSVLEQDYPAIEYFVMDGGSTDGSVKIIQRYARRLAGWVSEPDRGQADAINKGFARAHGEIVAWLNSDDLYLPGAVRAAVEIFERHPQAGMVFGDVVSIDGEGNPIHVMTFGDWGLEELMQFRIISQPGVFVRRQVLEQAGLLDLSYHYLLDHHLWLRCAQVAPMVYLRQRLACARFHPLAKNVAQAARFGQEAYRLVEWMAQEPVLSERFRRLEKPIRAGAHRLNARYLLDAGLIRPAASAYTRSLLTHAPTALVEWRRILFAYARLLVNVEGLKRLYLRARRRRMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W6</accession>
    <name>E8N1W6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_28870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28870"/>
    <dbReference type="REBASE" id="32158">
        <property type="entry name" value="M.AthUNI1ORF28870P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64913">
        <property type="protein sequence ID" value="BAJ64913"/>
        <property type="gene ID" value="ANT_28870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28870"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027633_1_0_0"/>
    <dbReference type="OMA" id="SHTTVAY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="483" mass="55057" checksum="9FAF9057280F80B2" modified="2011-04-05" version="1">MMSPKKTSQIKEQLALPFAPPQPMVWESEQAYIDRLKTLLEGDLDFHEQNSGYATHLIHSFPAKFPPQLPRLFIENLTQPGEIVLDPMAGSGTALLEACIAGRQAIGLDIDPLALRISYAKVHPLNTEQVLQSLHKILRNVEEQLKIREETDFQSEFAHTFDEETRQFISYWFSPAVSKPLFYLKKEIERVQEPVLRLFFEVAFSSLIITKSGGVSFALDLAHTRPHRAKIVYDEQGNEILREIPDTLSPARLKILTKTLRPVLPEFEKRVRINLRSELGKSEVNPLPIVLAGDAQNLPIARNTIDLIVTSPPYASNAIDYMRAHKFSLIWFGYPLGILSQNRRQYIGSDWVESIEESRFPPIVQEILMTLVQKDKKKMLAVQRYYREMKTVLTEMYRVLRPGRAAILVVGTSVIRGIDIRIGDCLAEIGTQIGFQVPAIGIRNLDRDRRMLPASKTNGNDSLIQQRMHQEYVIGFYKPSKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N216</accession>
    <name>E8N216_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561307.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29370"/>
    <dbReference type="EnsemblBacteria" id="BAJ64963">
        <property type="protein sequence ID" value="BAJ64963"/>
        <property type="gene ID" value="ANT_29370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29370"/>
    <dbReference type="eggNOG" id="ENOG503325R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1049443_0_0_0"/>
    <dbReference type="OMA" id="MENFLYE"/>
    <dbReference type="OrthoDB" id="1746523at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045706">
        <property type="entry name" value="DUF6062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19538">
        <property type="entry name" value="DUF6062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="241" mass="28040" checksum="491DF99F9DF768A7" modified="2011-04-05" version="1">MPFALTLIRLEEALRKPGCAVCRLEHEAALSAVDHLLWEQTNDPQTRQNVRQASGFCPEHTRLLTAMELSRSGPVLGVNLIYESLIESTLDDLRQRRAARKAPWTGWFRRAQPPAAMQCPICQQVHQAGMNILSSLMQALEERDERLREAYLQSDGICLRHLRGWLDAPGERFPRATDFVLEDTMERLKTQRGHMLEYIRKQNWEYREEALTPEERRAWIKVLTIFTGLPAERFDHHLPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N225</accession>
    <name>E8N225_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroQ</name>
        <name evidence="11" type="ordered locus">ANT_29460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561316.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64972">
        <property type="protein sequence ID" value="BAJ64972"/>
        <property type="gene ID" value="ANT_29460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29460"/>
    <dbReference type="eggNOG" id="COG0757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_0"/>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="OrthoDB" id="1872106at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="153" mass="16448" checksum="3A6FCD39E50C9D6A" modified="2011-04-05" version="1">MKKAYLILHGANLNLLGTREPQVYGAETLAEINARLHALAQELGVSIRCFQSNHEGELIEALHGARAWADGVVFNPGAFTHTSIALRDAIAAIGIPVVEVHLSNVVAREEFRHRSLIAPVCLGSIAGFGWQSYALALRALAERSGTEVARQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N237</accession>
    <name>E8N237_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561328.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64984">
        <property type="protein sequence ID" value="BAJ64984"/>
        <property type="gene ID" value="ANT_29580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29580"/>
    <dbReference type="HOGENOM" id="CLU_402090_0_0_0"/>
    <dbReference type="OrthoDB" id="1452844at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="684" mass="78582" checksum="001A1DCBAD0976D8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N238</accession>
    <name>E8N238_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561329.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64985">
        <property type="protein sequence ID" value="BAJ64985"/>
        <property type="gene ID" value="ANT_29590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29590"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_1_0"/>
    <dbReference type="OMA" id="IVVPMYF"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="322" mass="36563" checksum="032693B627F3EB92" modified="2011-04-05" version="1">MRTVGIVVPVFNEEEALPAFHRLLCQTIDSLPYHFFIYYVNDGSRDGTMNILQSICAQDTRVTVLELSRNFGHQAALTAGLDVAEGDFVISMDGDGQHPPDLIPEMLRLAQAGYDIVLTQRLEDGRLPLFKRLTADWFYRLINRISDTQILPGGADFRLMSRRAVDSLRRMREYHRFLRGMVSWMGFRSVILPYHPPERLAGHSKYTLRKMLKLARDAVFSFSLVPLYIGLSLGGVMLGLAVLEVIYVLSLWLSGDRASLAPGWSSLMFMLLFTNGILMILLGFVGVYVGYIFQEVKRRPIYLVRSVVQSPHPSAREDWEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N299</accession>
    <name>E8N299_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561387.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30200"/>
    <dbReference type="EnsemblBacteria" id="BAJ65046">
        <property type="protein sequence ID" value="BAJ65046"/>
        <property type="gene ID" value="ANT_30200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30200"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592854_0_0_0"/>
    <dbReference type="OMA" id="RTEATMY"/>
    <dbReference type="OrthoDB" id="643859at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030609">
        <property type="entry name" value="KLHL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF14">
        <property type="entry name" value="PTHR45632:SF14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="455" mass="48596" checksum="DB9A231B0C55AB3F" modified="2011-04-05" version="1">MELPNNEPLSEREIEILRLVATGASNKEIAQALSISPNTVKVHLRNIFAKIGVVSRTEATLYAIRNGITPPGFSLPETSPAEEEVPPESPLQVAALTREVEAPLPARRTLNRWALAGAALLILLLAGALVWNLTRPAASTPTPASTQTTPVAPPRWAVLKELPEARAGMAAIAFNERLYLFGGETETGISNDTLAYDPATDTWQALSGKPTAVSQIAAARLGEQIYLPGGMTAAQRPISALEVYSPLTDSWQSRAPLPQALAGYALTAFEGNLYLFGGWDGKTPSSAVYAYDPETNRWEERTPLPSPRVFAAAIAVEGRILLFGGSDGSQPLDEVWAYHPARESGGGTVWEALPAMPAPRAQMSAVGLINSIYLLGGISSNDEGNLPNWVFTPADGLWQALEPAPAPLGEQGVAVTYGNYLHIFGGKSGQTLQRTHLSYQALYTVAIPFIVDDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D5</accession>
    <name>E8N2D5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62741">
        <property type="protein sequence ID" value="BAJ62741"/>
        <property type="gene ID" value="ANT_07070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07070"/>
    <dbReference type="HOGENOM" id="CLU_3113959_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="50" mass="5856" checksum="FACBD01DF9010082" modified="2011-04-05" version="1">MNRLANLGFVEWQKITFVDSNEEITYQAPILTQKGYDQVNSGKYMNQQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K4</accession>
    <name>E8N2K4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559203.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07760"/>
    <dbReference type="EnsemblBacteria" id="BAJ62810">
        <property type="protein sequence ID" value="BAJ62810"/>
        <property type="gene ID" value="ANT_07760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07760"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_6_0"/>
    <dbReference type="OMA" id="PTYGMFE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="289" mass="32543" checksum="CE2A220BF2D27001" modified="2011-04-05" version="1">MKLCLALAQINTVLGNVQKNLEKHLAIIEEANSRGADLVVFPELSLTGYVLQDLTPMVACRPRVDDPVFAPLLAASQRLDIVVGFVEEDVRNRFYIAAAYLSRGKVLHVHRKVYLPTYGLFDEGRFFAWGDTVQAFDTSYGRVGMLICEDFWHASPPYLLWLDGADLFIFMSASPGRGVTGKEVLDSSRWVNHILRAYASLYTSFVAHTNRVGFEDGLNFWGQAALYDPNGDLLAEGPAFEEALTLVEIDLNQLHRTRARLPLLRDERTALVQRELNRIVSDRTHFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S5</accession>
    <name>E8N2S5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">surE</name>
        <name evidence="7" type="ordered locus">ANT_30490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561416.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30490"/>
    <dbReference type="EnsemblBacteria" id="BAJ65075">
        <property type="protein sequence ID" value="BAJ65075"/>
        <property type="gene ID" value="ANT_30490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30490"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_3_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="28290" checksum="FA8BADA820DC0635" modified="2011-04-05" version="1">MDKPLILLTNDDGIHSPGLHAAARALLPLGEVVVVAPREQQTSMGRSLPPASDGRIEPVTLPVNGGEVRAYALGGTPAQCVLHAVLEILPRTPALVVSGINYGENIGTGVTISGTVGAALEGGAMGIPSLAVSQAIEGEEYFAYTQIDFSAAAHFTALFAQKLLSRTLPVDVDVLKVDVPLGATPQTPWRVTRQSRHRYYIPYLIREGGWEQKGVVAASPKVRLEDTAPDDDIRAVVFDRVVSVTPLSVDLTSRTDLEDLEDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V6</accession>
    <name>E8N2V6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30800"/>
    <dbReference type="EnsemblBacteria" id="BAJ65106">
        <property type="protein sequence ID" value="BAJ65106"/>
        <property type="gene ID" value="ANT_30800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30800"/>
    <dbReference type="HOGENOM" id="CLU_1114042_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="249" mass="27141" checksum="088788047FB017B3" modified="2011-04-05" version="1">MRLRTVSLPNRAGRGSVSLRSRSVHIYVVASAEREATSALAGTFQEVATLAGLARDDTRLCHCNRGARFASVCAPPPTPSTGLRRSAEETLQGGAPKRRHMSLNLTTLLEQTRLFLHDSEGARYSTDDLTAAARMALMEINLVSAQGFVLAGLDGVDETTLPDSLQHLLVMGAAGYAASARAAAQAEWELAPQKTLPLALWSRNVMEDFRRILCTLYPPETARLHEQRTAAPFVRWEGTLSEEHPDHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X7</accession>
    <name>E8N2X7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">ANT_31010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561468.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31010"/>
    <dbReference type="EnsemblBacteria" id="BAJ65127">
        <property type="protein sequence ID" value="BAJ65127"/>
        <property type="gene ID" value="ANT_31010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31010"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_0"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ65127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="243" mass="26635" checksum="182C993B7E902FD4" modified="2011-04-05" version="1">METTLSNGLKYRRILLKLSGEALAQENGFGIDPNCVRAIAQRIKQVREMNVDVAVVIGAGNLWRGRVGQNSGMDPATADYMGMLATVMNALALMDALESMNVVTRVQSAIEMHSVAEPYIRRRAIRHLEKGRVVILGGGTGNPYFTTDTAAALRATELKCDVLIKATKVDGVYDSDPKKNPNARRFEHITYMDALNQRLAVMDSTALSLCMDNKMPILVLNLWDETALIRALKGEPVGTLVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y1</accession>
    <name>E8N2Y1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_31050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561472.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31050"/>
    <dbReference type="EnsemblBacteria" id="BAJ65131">
        <property type="protein sequence ID" value="BAJ65131"/>
        <property type="gene ID" value="ANT_31050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31050"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_3_2_0"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="198" mass="22059" checksum="3D6C4D1A2959BB90" modified="2011-04-05" version="1">MEPLITLGVVADTHVPDRVNALHPALIECLRAQGVQRILHAGDVCVPAVLDELEQVAPVSAARGNRDWMFTPALPWAVEMELGGARLALIHGQGSFLRYWWDKALYVLQGYRFERYRNVVLRACPHADVIIYGHTHQAENRREGGKLFFNPGSASLGIIPGRVPPSFGVLRIYAGGRVEGEIHVLKGWKVQRGRWVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N332</accession>
    <name>E8N332_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_31580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561522.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31580"/>
    <dbReference type="EnsemblBacteria" id="BAJ65182">
        <property type="protein sequence ID" value="BAJ65182"/>
        <property type="gene ID" value="ANT_31580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31580"/>
    <dbReference type="eggNOG" id="ENOG5032TN1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122755_0_0_0"/>
    <dbReference type="OrthoDB" id="1702147at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="147" mass="17368" checksum="9B5E506CA792FBD2" modified="2011-04-05" version="1">MSTFEDLFSGVNFKSTVTRYCQQIGWKVAEVDDRHAMLKFTMESGRNQVLWILRYDKTLEFSVPSMAQFDREEDIPHFLSTVLMRRSSQKKIGFWCIEEINGRFIYSCMHNAEIQLMDIPYFRDVVVALISECDEFEGILLDMLNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A2</accession>
    <name>E8N3A2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">melA</name>
        <name evidence="8" type="ordered locus">ANT_08820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559308.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08820"/>
    <dbReference type="EnsemblBacteria" id="BAJ62916">
        <property type="protein sequence ID" value="BAJ62916"/>
        <property type="gene ID" value="ANT_08820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08820"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="OMA" id="EYVPWYR"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="193"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="445" mass="49768" checksum="F6847594A202741D" modified="2011-04-05" version="1">MAKIVLIGAGSTVFTRNLCNDILLTPALQESEIVLMDINAERLNAAYKLVEALIEQRKLKARVQATLNRREAITGADYVITTFQQGGLEAYRLDIEIPLKYGVGQCVGDTLGPGGVFRALRTIPVLLDICDEMDDYAPDALLLNYVNPMAANCWAVSAGSGRPFVGLCHSVQGTSEMLARWVNVPYEEVNFLCAGINHQAFFLEFRRGKEDLYPALWEAIEKPEIYETEPVRCELMKYFGYFVTESSGHASEYVPYFRKSAEMIEQDLVPRFKSPQDFWFDFGRTGGYLRHCQRTAQTFQQEFQELLEGVRTLSNQRSHEYGSYIIEAIETNHPVKINGNVPNFGLIPNLPHGCTVEVPCLVDASGIQPVSVGDLPPQLAALNRTNINAQELIVEAALSGEVDAVYHAVMLDPLTAAVCTLPQIHAMVREMLEAERQWLPQFQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H4</accession>
    <name>E8N3H4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_09540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559379.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09540"/>
    <dbReference type="EnsemblBacteria" id="BAJ62988">
        <property type="protein sequence ID" value="BAJ62988"/>
        <property type="gene ID" value="ANT_09540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09540"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052321_2_0_0"/>
    <dbReference type="OMA" id="RWINNRA"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="3">
        <location>
            <begin position="188"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="429" mass="47822" checksum="6681565647590827" modified="2011-04-05" version="1">MNSRSAFLLILIFGFLITGLISLNGAIIALSIPLLVYFGVAAWYSPAPPRLVARRTLPLEAVFPETPVEVNLYLKNNGEDLQEVWIEDQLPAGLIVLEGETSRFLPLPAGEEVRLSYVVTGGRGDYRFTTLQVHYRESAGLFEGKIPVQASHRLMIRPRPRPLRSVPIRPPQTRGFAGPIPSRQGGVGVDFFLVREYQPGDPMRRINWKVTAREEQNLFTNLFEQQRVADVGIILDAREPGYGGASNNPLFEYAVDAAASLSETFLKDGNRVGMLVYGAGIDIAFPGAGKMQRQRILQTLARARLGSNFALESLSYLPTRFFPPRSQVILISPLQPHDPEVLVALRAHGYQVLVLSPNLIRFEAGQVRPNSPEELAQRIAQAERRFALQKLRRAGIQVLDWDVRMPLEQVLRQVISLRPLLRQGIGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N7</accession>
    <name>E8N3N7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5 6" type="synonym">rpsN</name>
        <name evidence="6" type="ordered locus">ANT_10170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559442.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10170"/>
    <dbReference type="EnsemblBacteria" id="BAJ63051">
        <property type="protein sequence ID" value="BAJ63051"/>
        <property type="gene ID" value="ANT_10170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10170"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_0"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="60" mass="7313" checksum="9282487A3F4A7A19" modified="2011-04-05" version="1">MAKKCMKYREMRRKYEVRVRNRCERCGRPRGYIRRFGLCRICFRELALQGKIPGVTKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P3</accession>
    <name>E8N3P3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">rplO</name>
        <name evidence="8" type="ordered locus">ANT_10230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559448.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10230"/>
    <dbReference type="EnsemblBacteria" id="BAJ63057">
        <property type="protein sequence ID" value="BAJ63057"/>
        <property type="gene ID" value="ANT_10230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10230"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_1_0"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="27"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="16173" checksum="313DE3495DC88AB2" modified="2011-04-05" version="1">MKLHDLFPNEGAKKKHKRKGIGIAAGQGKTAGRGTKGEGARSGQGGKLYRQGGNLPFYRRLPFMRGEGFTPPNQVEYNEVNVEQLERFPEGTVVTPELLAQAGMLHKNSNPVVILGRGELTRALTVQAQRVTKGARAKIEAAGGKVELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3R0</accession>
    <name>E8N3R0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559464.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63074">
        <property type="protein sequence ID" value="BAJ63074"/>
        <property type="gene ID" value="ANT_10400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10400"/>
    <dbReference type="HOGENOM" id="CLU_1412593_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="192" mass="21923" checksum="306CACCBF70C53E8" modified="2011-04-05" version="1">MRIKKGKFFFLGIALLLGVFLWVSFPAPVQQLAVPLKEWGHSFTEARFYIPQWGWTGRSVKLRVVLQQDGREKRVVRARMETSPEVSGGGEVSQVVQGGKSVQFSWQLTSMTQGRKTWRIWLWSDEPSGEERLLLVREGELLLLGFSGITVSWLQGIILLAMILFILLWVMGQNRQTRSSSDLVNCDKINKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3U7</accession>
    <name>E8N3U7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartokinase</fullName>
            <ecNumber evidence="12">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">ANT_10770</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="12"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559501.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63111">
        <property type="protein sequence ID" value="BAJ63111"/>
        <property type="gene ID" value="ANT_10770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10770"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_0_0"/>
    <dbReference type="OMA" id="DMIVQTI"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="413"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ63111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="476" mass="50127" checksum="EEFCDA2D3112C69D" modified="2011-04-05" version="1">MNDSSPRTLVMKFGGTSVGTPDAMAQTAEIIHRQRTLTPRLVVVTSALSGVTDILLSSAIAAAEGDTTTYNQSVQTLRARHEAIIKALIPDRARQEEVKAEITLLILDFANLCQAISVLGEATPRALDAVASLGERMAVRLLAAVVDSGGTPAQYLEANRLIITDDHFQSAHPDFAATQIAARASLNPILDQGTVPIVTGFIGATSQGITTTLGRGGSDYTAAILGAVLPADEVWIWTDVDGVMTADPRIVPEARTIEELTYREVSELAYAGAKVLHPKTIRPVIEAGIGLRVLNTFNPEHPGTRLVAEKATPNGNVVKSVTAIRGLKLITVEGRGMLGVPGVAARTFAAIASTGTSVSLISQASSEQAICFAVPASSAEKVIAAIENEFYREIAGKDIDRVWATSEVVIVTVVGEGMRSTPGIAGKVFSALGEKQINVIAIAQGSSEVSISFVLKAEDIRAAVQTLHERVITQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X9</accession>
    <name>E8N3X9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_11090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11090"/>
    <dbReference type="EnsemblBacteria" id="BAJ63143">
        <property type="protein sequence ID" value="BAJ63143"/>
        <property type="gene ID" value="ANT_11090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11090"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="HSEFVFM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="344" mass="37589" checksum="1540A9B3993938BD" modified="2011-04-05" version="1">MNAKGIKKVTIVDVAKEAGVSISTVSRVLNQNTPVAEETAQRVWEVIERLQFNPNAAARKLASKRTNTIGLIVPMIGGTFFPLMFSGIERGVNEEGFELLVYVSPCHPVPHRPLTPPVGPQNTDGLIVFTEGMSDEDLRALHVKGFPIVLLHRTSPKDCEIPYVTVENRLGTEKLIDHLIEVHGYTRIGFLRGPVTNEESHEREQGFRASLQKHGLQPDEALFGIGNFHPETAAESVRQMLSSGKRPQAIFTGDDASAAAVMKALLEMGVSIPDEIAIVGFDDDYLAPYLPLPLTTVHSPIEQAGYTAAQLLIQQIRGEAVQSQVLPTHLVIRRSCGCITSHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N405</accession>
    <name>E8N405_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
        <name evidence="5" type="ordered locus">ANT_11350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559557.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63169">
        <property type="protein sequence ID" value="BAJ63169"/>
        <property type="gene ID" value="ANT_11350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11350"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_0"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="331"/>
            <end position="332"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="380"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="406"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="483" mass="52205" checksum="D86628E05B703D4C" modified="2011-04-05" version="1">MITLQIFQKVSDYEWEIPPTFRSGMRVPVRIFATRRLLEKALQDASIEQAVNVATLPGLVGRVLVMPDMHQGYGFPIGGVAATRYPEGVISPGGIGYDINCGVRLLSSAIPYEAVEPYLDTLVAALDHHCPSGVGTHGAIRLSDKELDQACRLGSRWALKQGMASEQDLEFTEENGCIEGAAPEKVSARAKERGREQLGTLGAGNHFLEVEVVDQIFDAEAANAMGLFEGCLVLSIHCGSRGFGHQICSDYVQEFQGAVRRYGIQLPDRELVCAPLDSPEGQAYLGAMRAAANYAFLNRQILAHHARQAFEEVLSGKVKNWHLRQVYDIAHNIGKIETHEVDGKQVKVCVHRKGATRAFGPGSPAIPAAYRPIGQPVLVPGSMGTASWVLVGTETSMRISFGSSCHGAGRVMSRNEAKRQVRGEHLRKELEADGIHLRAGSLSGLAEEAPQAYKDVDAVVETVSGAGIARKVARLRPVAVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N447</accession>
    <name>E8N447_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_11770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559599.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63211">
        <property type="protein sequence ID" value="BAJ63211"/>
        <property type="gene ID" value="ANT_11770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11770"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_0"/>
    <dbReference type="OMA" id="FWEGGFF"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="441"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="560" mass="61929" checksum="324096CB2FA58AA8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N490</accession>
    <name>E8N490_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="8">GPR</shortName>
            <ecNumber evidence="8">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="8">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proA</name>
        <name evidence="10" type="ordered locus">ANT_12200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12200"/>
    <dbReference type="EnsemblBacteria" id="BAJ63254">
        <property type="protein sequence ID" value="BAJ63254"/>
        <property type="gene ID" value="ANT_12200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12200"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_0"/>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0521">NADP</keyword>
    <keyword evidence="7 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="7"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="421" mass="46890" checksum="410DCEE57CBBE3A9" modified="2011-04-05" version="1">MNMNLHEMGKQARWAGRKLASVASEQRTEALSILSEKLLEHAEEILEGNGQDVQRARELGLSEAMLDRLLLNPSRLQGMSDDLRRVAHLPDPLEEIFEERVLPNGLRLHKRRVPLGVLGVIYESRPNVTVDVVGLAIKSGNAVILRGGSETIESNRALIRVIHQALMEAGLPENCVQWIDDPDRKYVYELLQLDEFVDLIIPRGGASLHEFCRKNSRIPVITGGIGICHLFVEESADLEKSLPVILNAKVQRPTVCNALDTLLVQRSIADIFLPEVVRLLGDAGVSFKVDEIAWDILKDYQGIRISRAQPEDFDTEWLSLILGIRVVNDLEEAIEHIAQHSTGHSDGILTQNTALAEKFVQRVDSAAVYVNASTRFTDGGQFGLGAEVAISTQRIHARGPMGLRELTTYKWVVEGMYHVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A7</accession>
    <name>E8N4A7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative [LysW]-lysine hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">lysK</name>
        <name evidence="3" type="ordered locus">ANT_12370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:48684"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:9715"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:78526"/>
            <dbReference type="EC" id="3.5.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) or Co(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family. LysK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.130" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559659.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12370"/>
    <dbReference type="EnsemblBacteria" id="BAJ63271">
        <property type="protein sequence ID" value="BAJ63271"/>
        <property type="gene ID" value="ANT_12370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12370"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_0_0"/>
    <dbReference type="OMA" id="HMDTVPG"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01120">
        <property type="entry name" value="LysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010175">
        <property type="entry name" value="LysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01902">
        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="150"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="348" mass="37705" checksum="7813C6FD5F64BFFA" modified="2011-04-05" version="1">MDEVALLKDLVSRYSPTGEESKAVAFLVEEMQKAGFKAFVDSTGNAVGILGDGPNEIVLLGHIDTVQGEIPVRIEGDLLFGRGTVDAKGPLACLTAAAAQAGPQPGWKIIVIGALAEEGDSRGAKEILHTYHPHFAVIGEPSGWDRITLGYKGSAWIRYRVEKPMSHSASGKQTACETAVQFWNRLVKQTHQWNASTTRVFDQVTPSLRSMHSEQNGFVDTAELEINVRLPPAMPPERLMQEILLLDDEGTVNLLDGIPAYRGEKNSPLVRALLQAIRSEGGNPTFSLKTGTADLNLVAPVWSCPCVAYGPGDSNLDHTPNEHISLSEYRQSIRVLTQTLKTITQGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B4</accession>
    <name>E8N4B4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">argG</name>
        <name evidence="10" type="ordered locus">ANT_12440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559666.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12440"/>
    <dbReference type="EnsemblBacteria" id="BAJ63278">
        <property type="protein sequence ID" value="BAJ63278"/>
        <property type="gene ID" value="ANT_12440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12440"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_0"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="424" mass="47259" checksum="85AD57197CE5CAB9" modified="2011-04-05" version="1">MPKQTPSTPIKKVVLAYSGGLDTSIIVPWLKENYGCEVICFTADIGQGEELSGLPEKAKATGASKLYIEDLTEEFASQYLFKLLKSGAIYERHYLLGTSIARPLIAKHMVEIAHLENADAVAHGCTGKGNDQVRFELTVMALDPRLKVIAPWREWNIRSREDALEYAAAHQVPVSSTLKSIYSRDRNLWHLSHEGGLLEDPWAEPEESMYQITVAPEDAPDTPEYVEITFEEGTPVKLNGKALSSATLIKALNEIGGKHGIGRVDMVENRLVGMKSRGVYETPGGTILMRAHKELEQITLDRDTLHYKDVMAQRYAELVYYGQWFTPLREALDAFFEVTQKHVTGTVRLKLYKGNIITAGKKSVFSLYREDFATFGKDNVYDQSDAAGFITLFGLPLKVAAMRDIATAVQIASNAPDYSSFKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F8</accession>
    <name>E8N4F8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_12880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559710.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63322">
        <property type="protein sequence ID" value="BAJ63322"/>
        <property type="gene ID" value="ANT_12880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12880"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_0"/>
    <dbReference type="OMA" id="MRPCGDF"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="417" mass="45185" checksum="92FF64EB0C94251C" modified="2011-04-05" version="1">MKRISRTTLIFLGSIVAFTLVVQVLISLNVLSPFWNTILRQGAVMAIVSLGLNLIYGFNGQFSLGQWGFYAIGAYSAADITYRWTNDANSNGLTVLFFTVVLVGAAILILYRVFGKIRGVDPLSAFAIYLIAAIGLTALAVSIGNITAPGVNGLLKVLPANIANTVVYLLAVIIGGVLAAEVSFLFGLPVLTLGSDYFGIATLGFTIIVKVLLDNSDVMFGFVEMKGARGMIGIPKLTSWIWVMLFLILVLVITRNLLHSSYGRAIISVREDEIAAKAMGIDIGHYKTLTFVLGCLFAGLAGGLYAHINGFLHPDTFNFIKSFDPMIIVVFGGLGSVTGTIFAAFAWQLVLEGILRSILPPGFETWRYVVYPLLLLVMMLLKPNGLFGNYEIPYLRQVLPPKKSTEPKPAQTAKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G2</accession>
    <name>E8N4G2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559714.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12920"/>
    <dbReference type="EnsemblBacteria" id="BAJ63326">
        <property type="protein sequence ID" value="BAJ63326"/>
        <property type="gene ID" value="ANT_12920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12920"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033160_3_1_0"/>
    <dbReference type="OMA" id="MPCIVLD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="381" mass="41558" checksum="1D04C36F29D72552" modified="2011-04-05" version="1">MAEKILIVDDDVQTLRLVGLMLERQGYKILAASNGTQAISMARTERPDLILLDVMMPDVDGFSVARTLRKEPETADIPILMFTAKAQVEDKIAGYEAGADDYLTKPIHPAELTAHMRAILSRNKGRTGVPVERGYTIGVIGAKGGLGVSSLTLNVAINYFQNTKQEVIAAELRPGQGSWSTELGIQSCEGLNNLLRLNPSDINIATVENELIRVPYGIRLLLASPYAKDVPLMKNTAGMEAIVDQLSLIGRVTFLDIGTNTHLALDEILNLTREIIVVTEPFPAAIARTRILIEDLKQRGFGKGKLLSLVVVNRIRADVQLSVTQIQEMLGYSVSQVIPPAPEVSFQAATRNLPLIQVQIGGMLSLQYSRLAEAIAERVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X3</accession>
    <name>E8N4X3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="8">PCK</shortName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="4 8">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">pckA</name>
        <name evidence="9" type="ordered locus">ANT_14590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4 8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559869.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14590"/>
    <dbReference type="EnsemblBacteria" id="BAJ63487">
        <property type="protein sequence ID" value="BAJ63487"/>
        <property type="gene ID" value="ANT_14590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14590"/>
    <dbReference type="eggNOG" id="COG1866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_0"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="146648at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="236"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="443"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="542" mass="60450" checksum="DBC24B5C8D389AE3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N511</accession>
    <name>E8N511_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ordered locus">ANT_14970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559907.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63525">
        <property type="protein sequence ID" value="BAJ63525"/>
        <property type="gene ID" value="ANT_14970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14970"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_2_0_0"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="11"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="27839" checksum="BF9E84221D640FFB" modified="2011-04-05" version="1">MIKGILHLLPTSEILAQEAAKFIQQRITDTLQQKKRCSISLSGGNTPRKLYQVLASEPYLSSIPWNQIDFFWGDERCVPPDHPDSDYLMAKETMLDAITSRWQPGIYRIETEHSPAEAAARYEKTLREYFSDSSSGFDILLLGMGEDGHTASLFPFTQALHETKRWVVENYVPKLQAWRITLTAHFLNRAVTTMILVSGTNKKKVFTFIQTPNASPEAFPVLTIQPASGELHWFVDKDAFSENVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N524</accession>
    <name>E8N524_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ordered locus">ANT_15100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559920.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15100"/>
    <dbReference type="EnsemblBacteria" id="BAJ63538">
        <property type="protein sequence ID" value="BAJ63538"/>
        <property type="gene ID" value="ANT_15100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15100"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_0"/>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="13016" checksum="7DBC232D21088E4C" modified="2011-04-05" version="1">MINEPIHVTDAAFEKTVLQSTLPVIVDFWAPWCGPCKMIAPVLEKIAKEYAGKVIVAKVNTDENPEWAMKYGIQGIPTLLFFSNGKIVHRQVGALPERALRDIVSQFLEVVNSANTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N532</accession>
    <name>E8N532_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GBBH-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_15180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559928.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63546">
        <property type="protein sequence ID" value="BAJ63546"/>
        <property type="gene ID" value="ANT_15180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15180"/>
    <dbReference type="eggNOG" id="COG3536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117841_2_0_0"/>
    <dbReference type="OMA" id="PCATCHE"/>
    <dbReference type="OrthoDB" id="2003927at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBBH-like_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="118" mass="13483" checksum="1244881E62758C8B" modified="2011-04-05" version="1">MNLKELPQKITLNKKEQHLEIAWQDGHLSQYPFSLLRAACPCATCRGGHENMRSEPDPLVFDMTLADSPATQVEQVEMAGQYAITIHFQDGHHYGIYTWHFLRLLCPCPSCRSRVQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N539</accession>
    <name>E8N539_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DhaL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63553">
        <property type="protein sequence ID" value="BAJ63553"/>
        <property type="gene ID" value="ANT_15250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15250"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017496_1_0_0"/>
    <dbReference type="OMA" id="TRTIPQG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="564" mass="61185" checksum="F6185FD948BB30FB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N546</accession>
    <name>E8N546_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Folylpolyglutamate synthetase</fullName>
            <ecNumber evidence="6">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">folC</name>
        <name evidence="6" type="ordered locus">ANT_15320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559942.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63560">
        <property type="protein sequence ID" value="BAJ63560"/>
        <property type="gene ID" value="ANT_15320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15320"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_0"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="5">
        <location>
            <begin position="58"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="4">
        <location>
            <begin position="320"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="466" mass="52024" checksum="EF5B490165A0D070" modified="2011-04-05" version="1">MNEYEILYQESLDYLYSFVDYSLTRNFRYTPDKFNLDRIFKFLELLGNPQDKFFVFHVAGTKGKGSTSALIASALKAEGYRVGFYTSPHLQDYTERIQVNGEEISREDFVHLVEEIKPFVAMVPQLTTFEITTGMAFLYFARKGCHVAVIEVGLGGRLDATNVVTPTVSVITSLSMDHMNVLGDTLAKIAFEKAGIIKPGKPVVTSPQLPEAMAVLEQVARERGSALYKVGVDFHFAPWSHDLEGQTLFVWKEDEQDMVNSFIESGAHTDWEPLRLRIPLLGYHQVQNAATAYAALQIGKTCGVPVSDAAIQKGFSTVYWPGRFEILNRNPMLIVDSAHNRDSALKLRLTLDDYLPGKPVILLFGVSEDKDIAGMLGELLPRVKRVITTQSVHPRAMDAQTLVEWIHRYGVRAEAIVPVEKALASAMEIAQKSEAVILATGSLFVAAAVRHAWQNMLQPQFHQSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I2</accession>
    <name>E8N5I2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1540 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560075.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63696">
        <property type="protein sequence ID" value="BAJ63696"/>
        <property type="gene ID" value="ANT_16700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16700"/>
    <dbReference type="HOGENOM" id="CLU_2582034_0_0_0"/>
    <dbReference type="OrthoDB" id="2094585at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="2">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="80" mass="9501" checksum="FDC5C6D04E10E707" modified="2011-04-05" version="1">MPRIRCHYLDCVFWDEGYCSAAQVEIDPDKGCLTYSPNPESSAEDVWDETEEDLEEWDELELEEGEEDEDLWVDEDEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I3</accession>
    <name>E8N5I3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_16710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560076.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63697">
        <property type="protein sequence ID" value="BAJ63697"/>
        <property type="gene ID" value="ANT_16710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16710"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048252_1_0_0"/>
    <dbReference type="OMA" id="FFAMGNG"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="224"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="417" mass="45796" checksum="81EE8E6C5896F7AA" modified="2011-04-05" version="1">MQTEKAKHHRFNFVVNILDGAMFGMALGFASFSTVIPLFISTLSDSAIFIGMVSAVHVLGWQLPQLFIAPWLANKERMKPLVMIFTLQERLPFLGLAVVAFLLPSIGDTWGIVLAFVMLTWQAIGGGLTANPWQLMIHKIIFPEVLTTFFGIQAAALNLFAAVGAVFSGLILDRIPYPHNFALTFLIAGFWLAVSYAFINATKEPKGEANGAEAQFSSLWNAIITITRTDTNFNAVLGVRILGTIGMMGTAFYSVYAVNQLGASKTEAGILTSVLMISSVLTNLLLGWLADHWGHKKVLEIGGVAMFLSALLAALAPSFAWFYPVMFFTGISNTAMWTIMMAFVLTFGEEHQKPLYVGMANTLITPFTFAAPIFGGWLANLFGYPVVFWVSAIVSILCLGVLHFFVRERRSHRTEQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I8</accession>
    <name>SECD_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secD</name>
        <name type="ordered locus">ANT_16760</name>
    </gene>
    <organism>
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560081.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E8N5I8"/>
    <dbReference type="SMR" id="E8N5I8"/>
    <dbReference type="STRING" id="926569.ANT_16760"/>
    <dbReference type="EnsemblBacteria" id="BAJ63702">
        <property type="protein sequence ID" value="BAJ63702"/>
        <property type="gene ID" value="ANT_16760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16760"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_2_0"/>
    <dbReference type="OMA" id="MVVYYRL"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000412672" description="Protein translocase subunit SecD">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="464" mass="50867" checksum="76142F2EFF507BD8" modified="2011-04-05" version="1">MKRYYFTLALIVLLLGLTIWFNVPGHPQIKIGNFERSMDLIQGLDLQGGVQVLLEADLPAETPIDPQALEDARTILENRTNALGVSENLFQVAGERRIVAEFPGLSDPEKVLAVIKETGLLEFVDLQDNPENLQEGNLILTDFGQTSTSTQPTETTTAPATEGQESLASTTVYHTIMTGKDLKSVVVSRNPNTGEVVIDFTLSDEGAKIFDEYTSNNIGKILAIVLDKKIISAPRVQGRIPSGQGQITGNFTLETANNLAIQMRYGALPIPFKVVESRVIGPTLGRDSLQKSLLAGYIGFTIVILFMGIYYRLPGVMADLSLIVYALITLTLFRFIPVTLTLPGIAGFLLSTGSALDANILIFERLKEELRAGRTFSQALDLAWKRALPSIRDSNIATLITVVILFIFGSQFGATIVKGFAFTLGVGIFVSLFCAMVVTRTFMYILVDRMKPQAKHLKWFGILD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I9</accession>
    <name>SECF_ANATU</name>
    <protein>
        <recommendedName>
            <fullName>Protein translocase subunit SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secF</name>
        <name type="ordered locus">ANT_16770</name>
    </gene>
    <organism>
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560082.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="E8N5I9"/>
    <dbReference type="SMR" id="E8N5I9"/>
    <dbReference type="STRING" id="926569.ANT_16770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63703">
        <property type="protein sequence ID" value="BAJ63703"/>
        <property type="gene ID" value="ANT_16770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16770"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_0_0_0"/>
    <dbReference type="OMA" id="AFEWRMA"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000412692" description="Protein translocase subunit SecF">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <sequence length="308" mass="33789" checksum="2D1F6F4D4792F381" modified="2011-04-05" version="1">MLNILGKRYLFFAISLAMIIPGLIVMAIFGLPLSIDFKGGSLLEVEFASKTLPAPAEVVALYNDLGITDAQVTTTGNNTLLVRSSFIDDDVRAKVVQEMNSRFNDTVTVLRFDSVGPTIGKEVAGRATLAVSIAALAVIIYITWAFRGVHNAFRYGVCAIIAMIHDVLVVISLVSIGGVLFGWQVDALFLTALLSVIGFSVQDKVVVFDRIRENSQIYRKLDFEKLANHSIVQTLQRSINTQLMTVEYMLLAIALFGGITLREFAIILLVGLFMGTYSSIFIAAPSLVIWESGEWRNWFKRGAKPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K2</accession>
    <name>E8N5K2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_16900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63716">
        <property type="protein sequence ID" value="BAJ63716"/>
        <property type="gene ID" value="ANT_16900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16900"/>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_420734_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="299"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="435"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="651" mass="72657" checksum="B828A82A9BD9EE1F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L3</accession>
    <name>E8N5L3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560106.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63727">
        <property type="protein sequence ID" value="BAJ63727"/>
        <property type="gene ID" value="ANT_17010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17010"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_1_0"/>
    <dbReference type="OMA" id="PPEPIIF"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="31466" checksum="A95B9BCD33C8EF61" modified="2011-04-05" version="1">MKIAVVEYQSSVQVGIVEESQVFLLPQDISSSIEAIIHKGDRFVENILERKSTYESVSLSQVRLKAPLQNPEKIIGIGLNYKDHCREQNVPVPEYPLVFAKFSSSIIGNGDAICWNTELTRQVDFEVELGVIIGKKARNVSTQEALEYVFGYTIINDVSARDLQFRDRQWVRAKSLDTFCPMGPWIVTADEIPDPQALHLSTELNGVKMQNSSTAEMVFSVAELISFLSQAFTLQPGDIIATGTPDGVGVFRKPPVFLQNGDSLRMEIEKIGVLENTCKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N4</accession>
    <name>E8N5N4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="9">1.2.7.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_17220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560126.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63748">
        <property type="protein sequence ID" value="BAJ63748"/>
        <property type="gene ID" value="ANT_17220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17220"/>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_0"/>
    <dbReference type="OMA" id="HGCHRGC"/>
    <dbReference type="OrthoDB" id="332680at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="587" mass="62667" checksum="9A3917CD569FCB37" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q2</accession>
    <name>E8N5Q2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63766">
        <property type="protein sequence ID" value="BAJ63766"/>
        <property type="gene ID" value="ANT_17400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17400"/>
    <dbReference type="HOGENOM" id="CLU_2766838_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="69" mass="7771" checksum="E3BB1220C0D2951F" modified="2011-04-05" version="1">MRPSLTSQMELLAYNLVITALNRSTFIRTITRLVLSGSHQSKEWLWLVGLLACGVFGFVFGFCLVFFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S4</accession>
    <name>E8N5S4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560166.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17620"/>
    <dbReference type="EnsemblBacteria" id="BAJ63788">
        <property type="protein sequence ID" value="BAJ63788"/>
        <property type="gene ID" value="ANT_17620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17620"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_12_0"/>
    <dbReference type="OMA" id="HDAIAMT"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="202" mass="22865" checksum="D75C8A06DCBCFCE9" modified="2011-04-05" version="1">MQQRSEETRQKILQAAEALFAQKGYDATGVADLCEACGVSKGAFYHHFPTKQAVFLALLEDWLRQLDEQLQKTLSGHPNIPEGLIDLAKSTDAIFAASNTRARIFLEFWIQATRQPEIWQATVAPYHRYVERFTQLIRQSEIQGDLSLKKDIDPQIVARTILALALGMLLQAFFDPQGENWSQVTGKSIEWLFEALQKGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S8</accession>
    <name>E8N5S8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560170.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63792">
        <property type="protein sequence ID" value="BAJ63792"/>
        <property type="gene ID" value="ANT_17660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17660"/>
    <dbReference type="eggNOG" id="COG0579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_0_1_0"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="1371190at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="6"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="403" mass="44372" checksum="3142B778E62B6A50" modified="2011-04-05" version="1">MSQTFDIAIIGGGIVGLATAMALTQKYPKQSIIVLEAENRLAAHQTGNNSGVIHSGIYYKPGSLKAKNCVEGRTAMYEFCAQHGITHENCGKLIVATEQEELPRLDSLYERGIANGLTGLKKLRAEEIKDYEPHATGIAAIFVPQTGIVDYIGVTNAYAKIVKERDGEIWTGARVIGFQNRGSEFVLSTPKGEVVCRNLINCAGLYSDRVARMCGVNPVVRIIPFRGEYYELVPEKHHLVKNLIYPVPDPRFPFLGVHFTRMVKGGVEAGPNAVLAFKREGYKMGDISLRDLSEFLTFRGFWIMGFKYWQTAVGEFYRSLSKKAFVKALQRLLPELQEEDVHRSGAGVRAQALDPSGKLLDDFSIAEGQRMIHVLNAPSPAATASISIGKTIAEMASKNFSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W1</accession>
    <name>E8N5W1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SufR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560203.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63825">
        <property type="protein sequence ID" value="BAJ63825"/>
        <property type="gene ID" value="ANT_17990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17990"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078469_2_1_0"/>
    <dbReference type="OMA" id="LCQGHCP"/>
    <dbReference type="OrthoDB" id="1288973at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="213" mass="24037" checksum="60B241D20775324D" modified="2011-04-05" version="1">MEQIKSTRDRILHTLLTHPRSTIKELADAAGINGISVRHHLNALMAEGLIVIEEERHGVGRPRQVYSLSEKGMERFPSRYLRLTNRLLEQLKEALPAPMVSRLFEQIAEDIAAEAAEKVKSLPFEQKMEAVKQLLAQEGFTVEWEQQGDQYVIREITCPYYQIGQSHPEVCAVDQQLISTMLATPAEKVSCVLSGDPHCSYIISKKSIVEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y1</accession>
    <name>E8N5Y1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63845">
        <property type="protein sequence ID" value="BAJ63845"/>
        <property type="gene ID" value="ANT_18190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18190"/>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033149_2_0_0"/>
    <dbReference type="OMA" id="YGGLGPC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="353" mass="39146" checksum="063E842AF7CA2AF1" modified="2011-04-05" version="1">MSMNGMLPVLVGVRFSKVGKIYHFDATLVPDVEIGDSVVVETARGLQIGTVAQIFPTPEEIPEGLKRVERKATPQDLLIRQEWQAKEAEVVSVCKARARELGLSGVKIVAAEYSFDGTKLAILFSTETDERVDLKSLRQDMQRQYAPAQVELRQIGPRDVAKLLGGMGACGLESRCCSQFLCEFSSISIRMAKEQGISLTPSEITGMCGRLRCCLIYEFQQYAEARARLPKRNKRVVTPDGEGKVVDVVPLKGAVIVELSDGVRREYPGEKISLVGEPLPATPVVETEVEEESEPEEPEEESQEIGWEEMLLGEKPEAEPSSQKTQSGQQQSSPVSNRRSGKFRRKPKRKPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N609</accession>
    <name>E8N609_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560250.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63873">
        <property type="protein sequence ID" value="BAJ63873"/>
        <property type="gene ID" value="ANT_18470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18470"/>
    <dbReference type="eggNOG" id="COG0625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828069_0_0_0"/>
    <dbReference type="OrthoDB" id="1968326at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019206">
        <property type="entry name" value="DUF2085_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09858">
        <property type="entry name" value="DUF2085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="335" mass="38317" checksum="1D5E1690D1773A0C" modified="2011-04-05" version="1">MISLTFYYVPDSPECQAVDALLEKLKSELDFQITRIDISQKDPALLHSIGGRVPVIQVGPYRLTDPINEVQIRVAVGAARDRQVQMHKIGQQEWEDKVQRGRTVTQADYFSLWLSKNYIHVFNLLIFLYVGLPFLAPVLMKNGYERPASLIYRFYSFTCHQLPFRSWFLFGQQAYYPRELSGISGVITYEQAIGIENLFEARNFNGNPVVGYKVALCQRDVAIYLAMLGFGVVFALRGRRIKGIPWYLWVILGLFPIGIDGTSQLFGLVPNMPAWLPLRESTPFLRTVTGALFGLMTVWYLYPLIEQTMEDTYNLITRKIERASQNPAPESGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N616</accession>
    <name>E8N616_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18540"/>
    <dbReference type="EnsemblBacteria" id="BAJ63880">
        <property type="protein sequence ID" value="BAJ63880"/>
        <property type="gene ID" value="ANT_18540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18540"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_3_1_0"/>
    <dbReference type="OMA" id="TGNCHKW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="30"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="395" mass="45668" checksum="BA0145AFEE227CBE" modified="2011-04-05" version="1">MNNMYASLRRFFLLDPDVTFLNHGSFGATPHPVFEKYQEWQRLLEKEPVEFLGRRASEFLAQARQSIAPELGCKPDDFTFVTNATTGMNVVIHSLPLTSDDEVLTTNHEYGAVDKTWQFYSRQKGFKIVRARFSLPIDSQEKWLEELWRHVTPKTRVISLSHITSPTALIFPVEKVTERAKQEGILTIIDGAHAPGQIPLNLEKLDPDFYTGNFHKWVCAPKGAGFLYVRSEYHSMIQPLVVSWGYDNPSSQRSTFLDYTEWWGTRDISAFLSVPEAYHFLKVHHWDEVRQQCHQLLKDTCKELQTYLGAEPVATDPDIWNAQMLSLKIPNLHPKDIPEVSRKLWETYRIEVPLIEWEGSSLIRISLQAYNRWEDIKKLENALQNLLSSSSMQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N618</accession>
    <name>E8N618_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18560"/>
    <dbReference type="EnsemblBacteria" id="BAJ63882">
        <property type="protein sequence ID" value="BAJ63882"/>
        <property type="gene ID" value="ANT_18560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18560"/>
    <dbReference type="HOGENOM" id="CLU_2646595_0_0_0"/>
    <dbReference type="OMA" id="AGWLCIT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="76" mass="8558" checksum="CDF732CD79B322E5" modified="2011-04-05" version="1">MRNRDLREYARQTTTRLILGGLILLFVVGTALIYWRYGAGGALSGLLCMTIALFPIGLILIILALLEWLTKRIDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N661</accession>
    <name>E8N661_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">nusG</name>
        <name evidence="10" type="ordered locus">ANT_18990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560302.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63925">
        <property type="protein sequence ID" value="BAJ63925"/>
        <property type="gene ID" value="ANT_18990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18990"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_1_0"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="55"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="226" mass="26306" checksum="DAC4047554084715" modified="2011-04-05" version="1">MEEPKDQNFEADFLDEEKPRRRKSRSGEPRTPRKASVSAKPEEPVSKEGETETPERAWYVVHCYSGYENKVRHNLEQRIETMGMKDKIFDVVIPTQEEIEVKDGKRRTVERHVFPGYVLVNMIMTEESWYVVRNTPGVTGFVGMDQPTPLRPEEVAQILKRMEAEAPRVKVTFKVGERVRIVDGPFNDFRGTVSEIDMERNKVRVMVNFFGRETPVELDFLQVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N665</accession>
    <name>E8N665_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560305.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63929">
        <property type="protein sequence ID" value="BAJ63929"/>
        <property type="gene ID" value="ANT_19030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19030"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_3_0_0"/>
    <dbReference type="OMA" id="HFDHNAV"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="214" mass="23489" checksum="39CD0C16C08586D1" modified="2011-04-05" version="1">MEIFWYGHSCFRLVERGLASIVTDPFDHRVVGYEPLKLRADVVTISHDSPSHNYLDGVKGVSHVITGPGEYEIGGVFITGVQTNHRNGKEDTPRNTLYVFDYDGINVAHLGDLNHVPSQTEVENLGTVHIALVPVGDGSSLNAAKAAEVISLLEPNIVIPMHYHTPSCNLKLDPLNKFLKEMGLSEIETLPSLKISGTAGLPEETRVIVLDYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N669</accession>
    <name>E8N669_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ordered locus">ANT_19070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560309.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63933">
        <property type="protein sequence ID" value="BAJ63933"/>
        <property type="gene ID" value="ANT_19070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19070"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_0"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="362"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="548" mass="60564" checksum="062AA2DFD2ADCEE4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N693</accession>
    <name>E8N693_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560330.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63957">
        <property type="protein sequence ID" value="BAJ63957"/>
        <property type="gene ID" value="ANT_19310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19310"/>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_948791_0_0_0"/>
    <dbReference type="OrthoDB" id="2138746at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="32623" checksum="78C4F9CC3A5B2B7A" modified="2011-04-05" version="1">MLNPDSKKTPSPSKRRGQSFVELALILPILLVMLLGLVEVAIFVGRYLDVLDLTREAARFASVKDPFFIDMPGYWDCSGNQFFFYFHTACIFSPPSDQETEGGICWDRRFDHDNDPSTEIHDPFCNGLNPFITLDLTTDDVVISVYTVDGNNTVSRSHPGSNPDPRFAGDSVLDENGNITYFWALSNHDWDTAHNNNWQKDCQGNVVRQRPHYTTASVQQIINSSSVLNAQGTPVPAPGTKGYVAVELFYCYKQALNVPLFNVIVPNPVMIHAYTIMPLPAAQPTPTPIPSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6E9</accession>
    <name>E8N6E9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ruvB</name>
        <name evidence="9" type="ordered locus">ANT_19870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560384.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19870"/>
    <dbReference type="EnsemblBacteria" id="BAJ64013">
        <property type="protein sequence ID" value="BAJ64013"/>
        <property type="gene ID" value="ANT_19870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19870"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_0"/>
    <dbReference type="OMA" id="IHRMSRP"/>
    <dbReference type="OrthoDB" id="874197at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="54"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="344" mass="37998" checksum="A2D8D2CD3B94A89F" modified="2011-04-05" version="1">MSDTSQRFISPNPMPDEPVDPALRPVRLKDFIGQDQIRENLSILITAARQRNEPLEHVLFYGPPGLGKTTLAHVLANEMGVNIKITAGPAIEKAGDLAAILTNLKGGDILFIDEIHRLGKAIEEVLYPAMEDFALDIMIGKGPAARSIRLKLPRFTVIGATTRLALISAPLRARFGAVYRLDYYDVNAIEAILKRAASRLQMTVEPEGFREIAHRARGTPRVALRLLRRVRDFAQVRHQGLVTQAVAAEALNLLNVDPLGLDEVDRRVLSTIILKYNGGPVGLNTIAASIGEEPDTIMDVVEPYLLQLGFLDRTPQGRVATQRAYEHLSIPYPQTQSPNQPELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH9</accession>
    <name>E8MXH9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20340"/>
    <dbReference type="EnsemblBacteria" id="BAJ64060">
        <property type="protein sequence ID" value="BAJ64060"/>
        <property type="gene ID" value="ANT_20340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20340"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023978_1_1_0"/>
    <dbReference type="OMA" id="SICFRTE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="399" mass="45583" checksum="C79C09FF2CC1F87C" modified="2011-04-05" version="1">MIMAFVFWVLWLILLIPTLYWVLLAIASIYTPRRRAWQNELPQTRFAIAIPAHNEETVIAETVNRLQELDYPAHLFSVFIVADHCSDQTANKARAAGATVFERKEGPRSGKGAALSWLFQKIFADPTFQAIVVFDADTRVDKNFLRVMDMRLREGSQVIQGQHRIRNENDGWFPLLTWAMFLIDNRYQNLGRNNLGCSAKHMGDSICFRTEVLRKLGWGEGLTEDYQLRQRLLLEGIRIEYEPEALGLGEAPLTWQQARAQRARWLRGTRDASRTLAPQLLKQGIRKQNLAMLEGALQAYFPSFSTLSVIAVFFFFLLLLLYWTGRALPPSLLAAWGGLVMVLIFYPFGGLVLEKAPFKAFLAILTGPYFILWRTALALQARLSRKPVVWIRTAHGRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL1</accession>
    <name>E8MXL1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative bacterial type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_20660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560462.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64092">
        <property type="protein sequence ID" value="BAJ64092"/>
        <property type="gene ID" value="ANT_20660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20660"/>
    <dbReference type="eggNOG" id="COG4965">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064305_0_0_0"/>
    <dbReference type="OMA" id="WMRKIIR"/>
    <dbReference type="OrthoDB" id="1002350at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="150"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="323" mass="36004" checksum="EF235C3094B2B97F" modified="2011-04-05" version="1">MIDFTLILIIGGAVAVIMLIVGIVVSITSERSLVEERLGRYIETPAPVKERQTQAPVTEWLNKQVAGSSFGENIARELARADIKLKAGEYIALMIISAFLVGFVFYFLGDKNMLVGLAGAAIGLFLPRFYVKSQQAKRLVKFNEQLPDMLNLMVNGLRAGYSTMQAMEAVSKELPPPICDEFRRVVQEMQLGVPMQQALDNLLRRIPSDDLDLVVTAINVQREVGGNLAEILDTISFTIRERVRIKGEIRVLTTQVMYSGRFLAMMPIFVMGVLYLLNRPYMMEFFKPENNANLPCGYIALVCAAILIISGYVVMNKIGDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL2</accession>
    <name>E8MXL2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative bacterial type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_20670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64093">
        <property type="protein sequence ID" value="BAJ64093"/>
        <property type="gene ID" value="ANT_20670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20670"/>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056917_4_0_0"/>
    <dbReference type="OMA" id="SIKRAWP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="177"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="35485" checksum="2F4C2FCC83887CB9" modified="2011-04-05" version="1">MNLITIIIGVVGLVVIGAGALVYIGLRNPTSADDRLLQQRLEEFNQRGEQVDLEKIELSLPFSERVIFPMARKLGEIAVRFTPQNAMQDINRKLELAGNPGKLDATVFLALQFIAGGFFGAVLFLAMYFGQSNWPFGQKFLVVLGGTLLGFFFPQIWLTSKISRRQKEIRKSMPDALDLLTICVEAGLGFDAAMAKVAEKWESELSLAFARVIQEIQLGKTRRDALRDMAERIGIPEMTSFVAAVIQSEQLGVSMAKVLRIQSDQMRVRRRQAAEEEAHKAPVKMLIPMALLIFPSLMIVLMTPAALRLMNSALAGMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM8</accession>
    <name>E8MXM8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="5">1.1.1.169</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_20830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560479.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64109">
        <property type="protein sequence ID" value="BAJ64109"/>
        <property type="gene ID" value="ANT_20830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20830"/>
    <dbReference type="eggNOG" id="COG1893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_0_0_0"/>
    <dbReference type="OMA" id="CAQNGVE"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="186"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="37444" checksum="A3D351D850A90120" modified="2011-04-05" version="1">MAKPHTPKLKFLCFGAGAIGGYIGGSLILAGHSVTFLERPEQAETLQSRGLVLKNPAGTFKIASLQVVSSLEETITAGPYDLGILAVKSYDTQSLLESLAPYAIALPPILSLQNGVENEILLAQVLGEDRVVSGTVTTAVGKPEPGTIVVERLRGVGIAAEHPLAPTLVGVMDAAGLRARLYTNGRAMKWSKMLTNLMGNATSAILDMPPSEIYANPDLVKLEIAMLREALAVMQALQIPVVDLPGTPVKGLVFLSSLPIRLSQPLWQQVLGKGRGKKMPSFHIDLESGRGKSEVEFLNGAVVRFGQKAGVPAPVNRCLTELLMGITKGEIAWEDFRHNPTALLKRCGFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR1</accession>
    <name>E8MXR1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21160"/>
    <dbReference type="EnsemblBacteria" id="BAJ64142">
        <property type="protein sequence ID" value="BAJ64142"/>
        <property type="gene ID" value="ANT_21160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21160"/>
    <dbReference type="HOGENOM" id="CLU_3163991_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="47" mass="5555" checksum="CD75B8C3A92648CF" modified="2011-04-05" version="1">MTQENKIDSNPQPTVWFVISANQTIILNRRIKTFFKNLKFQWGGKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS5</accession>
    <name>E8MXS5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21300</name>
        <name evidence="3" type="ordered locus">ANT_23950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="2">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64156">
        <property type="protein sequence ID" value="BAJ64156"/>
        <property type="gene ID" value="ANT_21300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64421">
        <property type="protein sequence ID" value="BAJ64421"/>
        <property type="gene ID" value="ANT_23950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21300"/>
    <dbReference type="KEGG" id="atm:ANT_23950"/>
    <dbReference type="HOGENOM" id="CLU_1773540_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="146" mass="15814" checksum="2EB5BDFA1A4729C0" modified="2011-04-05" version="1">MQVEIDLSGVKKESGWYAVMTLLALLGLMALGRVFTPEGGRLLTWQEWQVRKLQQAYRAERLQLLEDTNRLAELLAGERPDPARVQVEVGAVRRRLSTQKVESLAAARAEVDAAAQAVLEWASGIGEYNAAVAAVQAALEALDGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ9</accession>
    <name>E8MXZ9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560599.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22040"/>
    <dbReference type="EnsemblBacteria" id="BAJ64230">
        <property type="protein sequence ID" value="BAJ64230"/>
        <property type="gene ID" value="ANT_22040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22040"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_6_1_0"/>
    <dbReference type="OrthoDB" id="1735902at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="158" mass="17632" checksum="B78C4AA92646DE5C" modified="2011-04-05" version="1">MTVEEHLAQAKKIVEPFAVEMASPDPWRLDVVILPANLIPVLQALKDAHWGYLSAITGLDYPPADGQEGQLEALYHLVMNGVVLTIRVKVPYAHPELESVCQVYPAASLYERELMEMFGFVLKGTPSTERLLLADDWPQGVYPLRKSFQSGKAQEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY26</accession>
    <name>E8MY26_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_22310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560625.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64257">
        <property type="protein sequence ID" value="BAJ64257"/>
        <property type="gene ID" value="ANT_22310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22310"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_2_0_0"/>
    <dbReference type="OMA" id="PMGWTAQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="152" mass="16391" checksum="389BBC897FBAD3EE" modified="2011-04-05" version="1">MKGRILAVDPGDVRIGLAISDPTGTIARALGVIHHVARAIDAATIAQIATEQGVVRIIVGQALDDHGLPTPQGRKSARLAEAIQQQTSIPVELWDESGSTNKAQDTRRIMGVKRKQRQGHLDDLAAVIILQDYLEAHLPPVSSSTLEEDLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY42</accession>
    <name>E8MY42_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative molybdenum cofactor biosynthesis protein D/E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaD</name>
        <name evidence="1" type="synonym">moaE</name>
        <name evidence="1" type="ordered locus">ANT_22470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560641.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22470"/>
    <dbReference type="EnsemblBacteria" id="BAJ64273">
        <property type="protein sequence ID" value="BAJ64273"/>
        <property type="gene ID" value="ANT_22470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22470"/>
    <dbReference type="eggNOG" id="COG0314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069141_1_0_0"/>
    <dbReference type="OMA" id="SEWKGHQ"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="233" mass="25852" checksum="B1FCA6AD09F7AE3E" modified="2011-04-05" version="1">MKVVVLMFASLKERAGFSRKELELPAESRVRDLKQLLSQSLPNLAGTMENVIVAVNRQFAFDEDLIPDQAEVALFPPVSGGAEFPTIVRVTTDVLDLDDLLARITLPTTGAACFFTGMVRAKTERGAPHETVRLEYEAYVPMAEAKMRQVAEEIRQRWPSVEGIAIVQRIGLLDAGTPTVLIACTAAHRDTGVFEAARYGIDRLKEIVPIWKKEIGPHGEVWVEGEYHPKRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY43</accession>
    <name>E8MY43_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">moaC</name>
        <name evidence="7" type="ordered locus">ANT_22480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22480"/>
    <dbReference type="EnsemblBacteria" id="BAJ64274">
        <property type="protein sequence ID" value="BAJ64274"/>
        <property type="gene ID" value="ANT_22480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22480"/>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_0_0"/>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="166" mass="17552" checksum="6FB8EBC328973996" modified="2011-04-05" version="1">MHFSVDKGGLTHIDESGSAHMVDVSGKPDTERTAIARGEVVLRPETLALIRQGLMKKGDVLGVAQIAGILGAKKTSELIPLCHPLPLHQVDVKLELDDALPGVRITALARTTGKTGVEMEALTAVAVAALTVYDMVKAVEKGARIHNIRLVEKHGGLSGDVINEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY64</accession>
    <name>E8MY64_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_22690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560662.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64295">
        <property type="protein sequence ID" value="BAJ64295"/>
        <property type="gene ID" value="ANT_22690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22690"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_0"/>
    <dbReference type="OMA" id="TMTERFN"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="36"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="353"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="605" mass="68162" checksum="9AB9C121FB0813B6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA5</accession>
    <name>E8MYA5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558448.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00160"/>
    <dbReference type="EnsemblBacteria" id="BAJ62050">
        <property type="protein sequence ID" value="BAJ62050"/>
        <property type="gene ID" value="ANT_00160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00160"/>
    <dbReference type="eggNOG" id="ENOG502ZGE4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1297671_0_0_0"/>
    <dbReference type="OrthoDB" id="12008at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="212" mass="23807" checksum="A0C03FEC6BE2DF31" modified="2011-04-05" version="1">MQTLLSTLRRRRWVWMLVNLALIALLTAVVPPEKTLGERIRLVYFHGAWVWTGKIAFALAGLSGLAALIFLPARSRLYPRWAEISLALGRTGLFFWLTYLPVSLLVQQINWGGIFWDEPRWRIPATFGVVAVLVQVAISLFDLPWLTVLVNAVFGAALWLALGGAENVLHPDSPIFSSNSVPIEGFFVALLGLSLLFMAQFALWMHDRRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA7</accession>
    <name>E8MYA7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative gluconokinase</fullName>
            <ecNumber evidence="4">2.7.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_00180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558450.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62052">
        <property type="protein sequence ID" value="BAJ62052"/>
        <property type="gene ID" value="ANT_00180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00180"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_2_0"/>
    <dbReference type="OMA" id="SDAMHFK"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="285"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="501" mass="53148" checksum="C444EF581DBE4692" modified="2011-04-05" version="1">MSPCFLGLDAGTGSCKSALLDENGNLIAEGSGAYRLPVHQTTTDQDAEAVLAGILQAGREALEKAGIPPQEVAGISLGAAMHSLLAVDAHGQPLTGAMTWADNRAQAQADALRGTPEGDALYRRTGCPIHPMYPLYKARWLKEHRPELFRRAAKLVTLRDYALYRLCGVWVTDPSMASSTGWFNLHTFGWDANALAFSGVSAAQLPEIHPPDTSFPLRPSPLADALGLLPGTPVTLGCSDGVNSNLGAGAVREGQAVLMIGTSGALRQFSAQARFHPGQGSWCYAVERGRFLAGGAINNGGLALTTLRDWFAALPGASALTVEDLLALAEQAPPGAGGLVALPFFSGERSPDWNAQARGVFFGLTPAHRPAHLARAVLEGVAFRLRAVMEMLAETGTVIREIRASGGFVRSPLWLSIVASVLGQPLHLPASGETSSRGAAFWAMRGAGALADFDILPERIAIVQTVHPDPLAQERYQRVYPLAQSLYRALLPFYDALAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS3</accession>
    <name>E8MYS3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64409">
        <property type="protein sequence ID" value="BAJ64409"/>
        <property type="gene ID" value="ANT_23830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23830"/>
    <dbReference type="eggNOG" id="COG4422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063017_0_0_0"/>
    <dbReference type="OMA" id="PWGYKGL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031009">
        <property type="entry name" value="Tcm_partner"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04474">
        <property type="entry name" value="tcm_partner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="365" mass="41988" checksum="C72859ED549E1CB7" modified="2011-04-05" version="1">MAPPQTKLWKIDPHTKAKHEILRRYLGAWFGILGQKIPRIVYIDGFCGPGEYEDGEPGSPLIALQQARPLATKYQNTEFVFIFIDERKDRIENLESKIRSEQYPQNMLIFPINGTFEEKMSELFSDLSDEGALLAPTFVFIDPFGFSGIPFDIVAKFLSNPKTEIFINIMVDSINRFLDHPNPEIKNHIIRMFGTSKVTKVLSGSGDRFQALRCLYQEQLLTHAKFVRYFEMRDQYNQPIYYLFFASSHRLGHLKMKEAFWKVDPQTGYLFSDATDPNQLVLFQDAPIVELANILAKKFCGQTVTTNEIIHDFVEDQTPYTASHAKKALSILENEQKIKVYAYKMDGSPRIRNSFPDGVSVEFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS4</accession>
    <name>E8MYS4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560776.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64410">
        <property type="protein sequence ID" value="BAJ64410"/>
        <property type="gene ID" value="ANT_23840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23840"/>
    <dbReference type="eggNOG" id="COG4422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054184_0_1_0"/>
    <dbReference type="OMA" id="KVSPGCK"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011101">
        <property type="entry name" value="DUF5131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07505">
        <property type="entry name" value="DUF5131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="240" mass="27848" checksum="90AE630BFA9601D4" modified="2011-04-05" version="1">MAGSRIEWTESTWNPLTGCNKVSPGCKHCYAERMAKRLKAMGQEKYRDGFRLTLHPEVLEEPLSWHKPQIIFVNSMSDLFHENVPVEFIQSVFDVMRRAYWHTFQVLTKRAERLLELDPILEWSANVWMGVSVENQNYTIRIDRLRNTHAKVKFLSLEPLLGPISNLNLEGINWVIVGGESGPHARPIKPEWVREIRDQCLANHVPFFFKQWGGTNKKKSGRLLDGERWDQMPILVPSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX9</accession>
    <name>E8MYX9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_24390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560820.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24390"/>
    <dbReference type="EnsemblBacteria" id="BAJ64465">
        <property type="protein sequence ID" value="BAJ64465"/>
        <property type="gene ID" value="ANT_24390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24390"/>
    <dbReference type="HOGENOM" id="CLU_851639_0_0_0"/>
    <dbReference type="OrthoDB" id="2159080at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003227979" evidence="2">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="36184" checksum="4B1078E05511E642" modified="2011-04-05" version="1">MRYGLVLFAALLITACAPAGYYAPADPQSLRATAQAFSQMAEAYNRLAGQTEQAYQAQATQTAQAYQVTAQYLDLRATQQAVDATATANAMLLAVQSYQATATLQALERKAREEQHAAEVTRQRAVVQSILETAIVFLALAALVVLFFVFLYRLLDAYVRWQETRRSIMISPIGVLVVRRDGMPPVHVEVLKPKPELPPGKDTETHDERGDLDWIPYRVGDQIMGFVKPEWRQKGEDPNRRLVLRLLRESIQKAGGNADHIPGWRELGWPAETWTRAVALLRPYVHPVPGRGGGTFLVGEYRTLAELYTALGSKQITLSPAPTEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYZ8</accession>
    <name>E8MYZ8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01070"/>
    <dbReference type="EnsemblBacteria" id="BAJ62141">
        <property type="protein sequence ID" value="BAJ62141"/>
        <property type="gene ID" value="ANT_01070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01070"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_4_0"/>
    <dbReference type="OMA" id="QVQNIDM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bac_transf" evidence="2">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="199" mass="22780" checksum="C57A9FB9FF13C217" modified="2011-04-05" version="1">MPLSKRLFDLTLAVLALVLLSPVLLFTALAVRLGLGKPVLFRQPRPGYRGRVFTLYKFRTMRDALAPDGTPLPDDQRLTPLGRFLRATSLDELPELFNVLKGEMSLVGPRPLLVKYLPLYTPEQMRRHEVLPGITGWAQINGRNALSWQDKFRLDVWYVDHWSFWLDVKILILTVWKVLRREGINQPGQATASEFDGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ24</accession>
    <name>E8MZ24_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558565.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62167">
        <property type="protein sequence ID" value="BAJ62167"/>
        <property type="gene ID" value="ANT_01330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01330"/>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514873_0_0_0"/>
    <dbReference type="OMA" id="TEAVWRS"/>
    <dbReference type="OrthoDB" id="1580596at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="46"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="177" mass="19505" checksum="71E4ADE847BA32C2" modified="2011-04-05" version="1">MRRPRTSLWLYLLLNIVVSAATMLAVLYFWERAHGRAQSILPVFPTPSAAEASPTPTSLPPEEMLPSPTPYTGEPLVQIIAVIGATDPQQEYVVLKRVGQGDLNMDGWVLRDEDGNELRFPAGLTLFPNGGLLIYTRAGTDTVSELYWNRTEAVWRSGEVVTLLDPAGQVHATYTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ29</accession>
    <name>E8MZ29_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558570.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01380"/>
    <dbReference type="EnsemblBacteria" id="BAJ62172">
        <property type="protein sequence ID" value="BAJ62172"/>
        <property type="gene ID" value="ANT_01380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01380"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_0"/>
    <dbReference type="OMA" id="DPEQWAW"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="163"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="399" mass="44562" checksum="1B563F9DAF2754A4" modified="2011-04-05" version="1">MTSYLIRRLFQMIIVILVSAAASYALLNLAPGGPLTGLRQMQQNSRFRITEEDFARIRAYFELDLYLPVRFSRWLIGFPSGPVKIFGQELFANVPVGCYKEIQATFQDAKGNFSVRTIGCKEYVYLKDLEGRRVSKGVLRGDFGNSWRLNRDRPVVDLLVSRIPNTVKLMGISTLLALVLGLPLGVYSAIKQYSRFDYIFTSLAFMGSAMPTFFFGILSIMIFSILPNRLGWFYLPAGSATAVRDYTIPLLGTVKAGSGLDQGLHLVLPVFVLTIVSIAGWSRFIRGSMLEVMRQDYVRTARAKGLTERVVIMKHALRNGLIPFVTIVVFTLPGLIGGAIITETIFSWPGMGRLYFLALGDSDYPTAMAILFLTAVLTVIATLLRDILYTIVDPRIRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ49</accession>
    <name>E8MZ49_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation-transporting ATPase</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_01580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558590.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62192">
        <property type="protein sequence ID" value="BAJ62192"/>
        <property type="gene ID" value="ANT_01580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01580"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_4_1_0"/>
    <dbReference type="OMA" id="FGIDDYI"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="881"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="912" mass="99077" checksum="4022F6844D26B845" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ73</accession>
    <name>E8MZ73_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01820"/>
    <dbReference type="EnsemblBacteria" id="BAJ62216">
        <property type="protein sequence ID" value="BAJ62216"/>
        <property type="gene ID" value="ANT_01820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01820"/>
    <dbReference type="HOGENOM" id="CLU_3179504_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="46" mass="5388" checksum="FEC0950F937850CE" modified="2011-04-05" version="1">MNNFIIGRFTRRASHPIGVIFPPERDKGKLYPQTCLDHLKKCGWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ74</accession>
    <name>E8MZ74_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dnaE</name>
        <name evidence="11" type="ordered locus">ANT_01830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558615.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01830"/>
    <dbReference type="EnsemblBacteria" id="BAJ62217">
        <property type="protein sequence ID" value="BAJ62217"/>
        <property type="gene ID" value="ANT_01830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01830"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_0_0_0"/>
    <dbReference type="OMA" id="NECRRMG"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="10">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1126"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1321" mass="147997" checksum="12CA3D23271CCAEC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ90</accession>
    <name>E8MZ90_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01990"/>
    <dbReference type="EnsemblBacteria" id="BAJ62233">
        <property type="protein sequence ID" value="BAJ62233"/>
        <property type="gene ID" value="ANT_01990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01990"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697641_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002860">
        <property type="entry name" value="BNR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02012">
        <property type="entry name" value="BNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225175" evidence="2">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="395" mass="43078" checksum="3366BBDF4E9C2E55" modified="2011-04-05" version="1">MKKLLLSLVLMLWAVSACAPRIPPVPSLQAQSLPEATPSPSPAPTFTAVPSPTETLPAPVPSSGSLLPFTQLTRLDALNGWGVRDTRVLRTTDGGRTWQDVTPSDLHSEMTVTLSGFFPSAEEAWVCLPALDRYDSGTLYRTTDGGQTWQSAPAPFGWANFFRAPASAQTVLAQVSLQGLVELHRTRDGGQTWELVMRSTAGDEDAPGRLPVGMHTQWQIAAQDEQTLWAAGISPAVDGLYLYRSGDGGVRWERRPLDLPQSPSGFYAEGLRFFDGQSGAFSIFYGSETFQRAFFVTRDGGASWQLTPGIPAVGNTWSAPDALHWWVWDGENLRLSQDGGWTWQTAPANPPETPESLVFSDPLTGWAVQYDENGHRLYGTTDGAQTWELLAEDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC6</accession>
    <name>E8MZC6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LuxR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_24480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560829.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24480"/>
    <dbReference type="EnsemblBacteria" id="BAJ64474">
        <property type="protein sequence ID" value="BAJ64474"/>
        <property type="gene ID" value="ANT_24480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24480"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945601_0_0_0"/>
    <dbReference type="OMA" id="WHLITEG"/>
    <dbReference type="OrthoDB" id="1192714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019092">
        <property type="entry name" value="CRISPR-assoc_prot_NE0113/Csx12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09623">
        <property type="entry name" value="Cas_NE0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="218"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="298" mass="33493" checksum="67C57143835970D3" modified="2011-04-05" version="1">MTSHSHRPATLIATLGSEPQVVTAGLDLLLKQRVNVHSVEIVHTSAIPDSPIHEAVLKLTQACQDYSAPLCEAFHFHPLLVDGIPVADVESASASQAVFRLLYTCVWNAKQRGDIVHLLIAGGRKTMSIYGMVVGQMLFDESDRLWHLFSAGDFLTSKRMHPQPGDQVELSEIPVIRWSEISPIIGVLRSSEDAMSALETIRSFQIERRNKEVERFIQKHLTPAERRVVACLLEEGEGDEEIAQRLHLSPRTVEQHLRSVYAKAQDFWGIERVTRSGLIILLSPHQWAKIRENPHDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI6</accession>
    <name>E8MZI6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560889.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25080"/>
    <dbReference type="EnsemblBacteria" id="BAJ64534">
        <property type="protein sequence ID" value="BAJ64534"/>
        <property type="gene ID" value="ANT_25080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25080"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OMA" id="TTDYRSH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="16"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="327" mass="36406" checksum="ECD296499DC8C440" modified="2011-04-05" version="1">MEYRLLGRTGVRVSQLCFGTMTFGGDADEETSAALYRRCREAGINFFDCANIYNGGKSEELLGRFVKGHRQEVILTSKVYFPPNQDVNARGATRRNIMLNVEESLRRLGTDYLDVYFIHRFDELTPLEETLRALDDLVQAGKVLYLGASNFAAWQIAKALGISARYGWSPFAVIQPMYNLVKRQAEVEILPLALSEGLGVIPYSPLGAGLLTGKYGVTSRPEQGRLVEHPIYKVRYGDEWMYEVAERFVHFARERGYSPAALAVAWVGSHPAVTAPIIGARNLAQLEESLLSLQIQMTPELRAEISSLSPEPPPATDRTEEARGKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ9</accession>
    <name>E8MZJ9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560902.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64547">
        <property type="protein sequence ID" value="BAJ64547"/>
        <property type="gene ID" value="ANT_25210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25210"/>
    <dbReference type="HOGENOM" id="CLU_1544461_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="177" mass="20978" checksum="12B68B15CFCE8AA0" modified="2011-04-05" version="1">MSETTPSTLEKALQKAVQLERMTGTLYLQFTRLFDHHPEICQFWKEYATEEEEHAAYLEKLREGLPEHRRKEPVDPDLDRRLNHCLQKMGEISPEKILTLRDAHQLAVEIENSETNSIFEFFVLHLSPDHSTSHIEFLREQLNNHLQRLEADFPEAYRGIFAQRNTLTHHKNQDKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZL1</accession>
    <name>E8MZL1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560914.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25330"/>
    <dbReference type="EnsemblBacteria" id="BAJ64559">
        <property type="protein sequence ID" value="BAJ64559"/>
        <property type="gene ID" value="ANT_25330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25330"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056918_0_0_0"/>
    <dbReference type="OMA" id="NLMWGDG"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228504" evidence="1">
        <location>
            <begin position="25"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="37806" checksum="CCA12EC1F8C2F83C" modified="2011-04-05" version="1">MLDSSRLKSVLLATLVLLAGVLAACEKPVPSQSAITAYFTNPVSPAQNQALQNALVDSLNNASTSVDIAMYNFNLLEVGNALRNARQNGVKVRLVVDSDALDSNLLQQLRREGFEVLGDRRETLMHNKFIVIDRKIVWTGSLNLTYGGLTNDENNLVCIESPELAQRYTEEFNEMFEEDVFGGGEPLGARSALSLNGSDAWLYFSPEDRPSQAIVDRVKQAQTSIDILAYNFTLNDLRDALLEAAHRGLDVRIVFDADQAASTGGEYSTLKNAGLDVRLDGASGLMHHKAIILDRNTVIFGSYNFTRSADLNNDENVLIIDNKELAKQFRQTFERIYSQAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP4</accession>
    <name>E8MZP4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_25660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560947.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64592">
        <property type="protein sequence ID" value="BAJ64592"/>
        <property type="gene ID" value="ANT_25660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25660"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002018_0_0_0"/>
    <dbReference type="OMA" id="LDRYPYG"/>
    <dbReference type="OrthoDB" id="231654at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041246">
        <property type="entry name" value="Bact_MG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17973">
        <property type="entry name" value="bMG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="A2M_N_2" evidence="4">
        <location>
            <begin position="1068"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="A2M" evidence="5">
        <location>
            <begin position="1276"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1989" mass="218972" checksum="70970EC90EE998D6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP7</accession>
    <name>E8MZP7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64595">
        <property type="protein sequence ID" value="BAJ64595"/>
        <property type="gene ID" value="ANT_25690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25690"/>
    <dbReference type="eggNOG" id="COG3287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711051_0_0_0"/>
    <dbReference type="OMA" id="PYYKLSH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FIST" evidence="1">
        <location>
            <begin position="36"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="2">
        <location>
            <begin position="226"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="388" mass="40965" checksum="A768B56491E41A07" modified="2011-04-05" version="1">MSMTRIAVYGVGQGLDGRDAAMKATQKALDQLGALRPALGIVFASEEFDLGEVASGMAGLLGETPLWGMSTVRPLAGDREVPRSVVVALVAGGDLKAQAHFWNTFALDSTETARQVMRHFRSDLMLPQAVLLAADGVNGTLAPLCSMLADLPVAVGGGLASGGFSSGKTAVVGRGQAGHSALSTVTLGGRFRLGTGSGHGWRDTGLHATIGKTRDVWVQTIEDRPAVELYVQYFGHEPREWAYPPLNEVVRLYPLGIENNGNLLVRSPLRVEVDGSLRMSAVVPSGSVAHLMLGDPQACLESAEAAVRHALDEIGPARPLIALALVDLAWLQLFNMRSGQIVATIQDTLGSIPVIGGYSLGQIARPAINYAPMIYNQSVTILILASQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ7</accession>
    <name>E8MZQ7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_25790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64605">
        <property type="protein sequence ID" value="BAJ64605"/>
        <property type="gene ID" value="ANT_25790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25790"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_0"/>
    <dbReference type="OMA" id="PRRVIMF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="77"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="33172" checksum="32923F26178ACE09" modified="2011-04-05" version="1">MSMITSKRLQDRIIDWFIALFLLALGISTLLPLINTLAISLSERAAVSGGMVKLTPVGFNLTAYEYILQDTKFWRAFGISVLRVALGGLLNFALAVLTAFPLSRSEKAFPGRNIFIWMFVFGMILNVGIVPWYLTIAQYKLIDTIWALVLPGAVPIWNVIILMNFFRNIPKELDEAARIDGANPWQLLWHIYLPTSLPALATITLFSIVGHWNSFFDGLILMNNPDNYPLQTYIQQLVIADRPILHGGQAQLMVKLSNATLNAAKLFVAMIPILIIYPFLQRYFVRGIMLGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT5</accession>
    <name>E8MZT5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558667.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62270">
        <property type="protein sequence ID" value="BAJ62270"/>
        <property type="gene ID" value="ANT_02360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02360"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_0"/>
    <dbReference type="OMA" id="MDYADLE"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="268" mass="28556" checksum="4142E5D7575E62C7" modified="2011-04-05" version="1">MKVQNKVFVVTGGGSGIGRALVLGLLARGARVAAVDLNPATLQETANLAGEKQANLSTHVANIAQREAVEALPAQVIERHGAVDGLINNAGIIHPFVKVNDLTYDVIERVMNVNFYGTLYMIKTFLSYLLQRPEAHIANVSSMGGFVPVPGQTLYGASKAAVKLLTEGLRSELMDTPVKVSVIFPGAVGTNIAANSGVNIQSHGGQSSRAMKVLQPEEAARIILDGIEQDRARILVGSDSTFMDRLSRLSPERAAKLIYQQMKSLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ3</accession>
    <name>E8MZZ3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02940"/>
    <dbReference type="EnsemblBacteria" id="BAJ62328">
        <property type="protein sequence ID" value="BAJ62328"/>
        <property type="gene ID" value="ANT_02940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02940"/>
    <dbReference type="HOGENOM" id="CLU_3179505_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="46" mass="5429" checksum="8EE9739CA0491FBF" modified="2011-04-05" version="1">MKNSRVFYILDVFQRRENAGFAIPEAMFEFLPLVWAIQLEMSFSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N019</accession>
    <name>E8N019_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558751.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03200"/>
    <dbReference type="EnsemblBacteria" id="BAJ62354">
        <property type="protein sequence ID" value="BAJ62354"/>
        <property type="gene ID" value="ANT_03200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03200"/>
    <dbReference type="HOGENOM" id="CLU_193886_1_0_0"/>
    <dbReference type="OrthoDB" id="2039523at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="74" mass="8449" checksum="E2EEA7E7CAED4538" modified="2011-04-05" version="1">MSTMMKPLAEINQQAIQLLYQELGVVNAVRFLRQFTTGFGDYTRERASLFAGKSLQEIVHEIEQQKGQSLPHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N040</accession>
    <name>E8N040_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558772.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62375">
        <property type="protein sequence ID" value="BAJ62375"/>
        <property type="gene ID" value="ANT_03410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03410"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_3_1_0"/>
    <dbReference type="OMA" id="YWSLPGT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraR_C" evidence="1">
        <location>
            <begin position="139"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="217" mass="24731" checksum="D5B34A815A4AA9F4" modified="2011-04-05" version="1">MSLMDEVLPHVDVRVVAFCLLKERLHVLVCSASANGYELPGAPVLLNCSLEETAARRLGELTGIRETYLEQLYTYGEPQRANPRLISVAYFALLPANRLSKTPPHPACWFAVDALPALTGDHAEIIAYALRRLRYKLEYSAVGFQLLPERFTLSELQRTYEMILGEKLDKRNFRRRILRAGIIEPTTECRTGEGRPARLYRYRPDAVAEVKARRLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N042</accession>
    <name>E8N042_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_03430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03430"/>
    <dbReference type="EnsemblBacteria" id="BAJ62377">
        <property type="protein sequence ID" value="BAJ62377"/>
        <property type="gene ID" value="ANT_03430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03430"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705238_0_0_0"/>
    <dbReference type="OMA" id="LAYWHHP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="158"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="391" mass="43006" checksum="CA34FA7F09CB38F7" modified="2011-04-05" version="1">MRCAVLTNATRFRNYGKGAECPKPSPVTGREVSLLTGTTLAMTLPVRLPCPWAIIPSMPRQFWLWLFLFFLALAGCAPQGAVPVVPSASPLLPSMTFPPSDTPSPTLTASPSPTATLTPTFTPTPTPAVLAGAGDISICGQDGDDQTAQLLMNLPGEVFTAGDNSNEQGKPIQYRQCFDASWGRLMSRLHPAPGNHDYGTDEGAPYFAYFGERAGPPGRGYYSYELGAWHILALNSNCEYAGGCGADSEQERWLREDLLSHPNRCTLAYWHHPRWSSGWHGSDARTDAFWRALYDFGAEVVVSGHDHHYERFAPQSPEGERDDLRGIRQFIAGTGGVSLRGYEEIHPLSEVRYNDTFGVLVFILYPDRYEWQFLSVDGARVIDSGSDECHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N050</accession>
    <name>E8N050_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">frr</name>
        <name evidence="6" type="ordered locus">ANT_03510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558782.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62385">
        <property type="protein sequence ID" value="BAJ62385"/>
        <property type="gene ID" value="ANT_03510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03510"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_0"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="185" mass="21204" checksum="79D9810D351B721C" modified="2011-04-05" version="1">MIKETLKEAETRMKGAIQALEENLAGIRTGRASPALVERLQVEYYGVPTPLMQLASISAPEPRVLMIRPFDTSSLRLIEKAIMASDLGLTPNNDGKVIRLNIPPLTEERRRELVKVVHARLEESRIAVRNVRRDMVKDLRDFEKEKLISEDDLKKGEEELQKLTDRYIQEIDAIGQKKEKEIMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N059</accession>
    <name>E8N059_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558791.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62394">
        <property type="protein sequence ID" value="BAJ62394"/>
        <property type="gene ID" value="ANT_03600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03600"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076204_3_0_0"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="18967" checksum="1930275F1EA9D83B" modified="2011-04-05" version="1">MPLILNQPAPDFTLPSVSGEAVTLSALRGKPVLINFWSAECPWAEQADRLLVERWKTFQNQAVWISIASNANETSEQIREVAQARGLPLVLVDAGHRVADVYEAVTTPHCFVLDANGILRYHGALDDTSFRQRVPARFYALEALEAILKGETPAIQHIPSYGCTIVREMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8N069</accession>
    <name>E8N069_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03700"/>
    <dbReference type="EnsemblBacteria" id="BAJ62404">
        <property type="protein sequence ID" value="BAJ62404"/>
        <property type="gene ID" value="ANT_03700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03700"/>
    <dbReference type="HOGENOM" id="CLU_914130_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="304" mass="35136" checksum="C9B1B167D86BB73B" modified="2011-04-05" version="1">MKRMHQTMLFPDALREFTFAKSYEQIVQLLQDYPELDEYVIPILSLMSTLGLMLEVEKAFGETSETQERVIEIVDPATIEILQQKPTARETAQTINLLISIGRRNPAVFTEEACTMLKILAEGDIPANLKPKLLRYHAALRASRDSGFDLEWALKKKREAEWVDEDWEKADQQSEQMKAFLLAPNVESARAVVHQSHWLEPYLEEGGLSFSGEDLSLRHGLAHALWEKSWCRVRRTVREYAELTTPRAWEVLDQFAETAKKHQKKQTVHEVLAIKFEYFSVLLKKCAEQGVDRVFLEYANHFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B9</accession>
    <name>E8N0B9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561022.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64668">
        <property type="protein sequence ID" value="BAJ64668"/>
        <property type="gene ID" value="ANT_26420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26420"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_6_3_0"/>
    <dbReference type="OMA" id="ERAHYED"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="2">
        <location>
            <begin position="44"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="311" mass="32746" checksum="E532F8D86D9B7888" modified="2011-04-05" version="1">MHRFLRSFPILLFIFVVGLSGCNPAGITPQATPLSANDLADSTITASGTVIPAQYQWVGFESGGTLRELLVATGDTVSPGQILARLDETILRAAVTQAKAALIRARNIRNELEELPKEDSRAAAVAAVASAEANLDRLERSGARQIEIDAAKAQLESARASLKALEEGASRAQITQADADVEAAQAALEQAEAALRSATLQAPFGGQVVEIAPKVGDVLAPGQPIILLADLSKMQVETTDLSEVDVAQIAIGDDVLVTFDALEGITVRGKVVKIALKAAPGVNVTYPVTIELENPPQSLRWGMTAFIKIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F5</accession>
    <name>E8N0F5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26780"/>
    <dbReference type="EnsemblBacteria" id="BAJ64704">
        <property type="protein sequence ID" value="BAJ64704"/>
        <property type="gene ID" value="ANT_26780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26780"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105867_0_0_0"/>
    <dbReference type="OMA" id="VCWCLSY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="195" mass="21830" checksum="3A9CF1B38B27EF2E" modified="2011-04-05" version="1">MNTPQESAYTFHLLTPERWADFERLFGAHGAYGGCWCMFWFLRGSAFTRGQGEANRLAMKSRVEAGETPGMLAYLGDEPVGWCAFGPREGYPRLQASRTLKPVDNLPVWSVVCFYVAKGHRRRGVSKALLKAVIEEVRRRGGKVVEGYPSPSTGEGRPDPFVYLGLEAAFREAGFVDVARPTPHRLIMRYVIENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G2</accession>
    <name>E8N0G2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561063.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26850"/>
    <dbReference type="EnsemblBacteria" id="BAJ64711">
        <property type="protein sequence ID" value="BAJ64711"/>
        <property type="gene ID" value="ANT_26850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26850"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_0"/>
    <dbReference type="OMA" id="ESCPAFC"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="63" mass="6815" checksum="33C0CDC44C525748" modified="2011-04-05" version="1">MKAFVDRDLCMGCGVCETIAPSVFKLEDDGIAVVLVDVVPPEEEANVREAMDSCPEQAISIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G6</accession>
    <name>E8N0G6_ANATU</name>
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        <submittedName>
            <fullName evidence="4">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26890"/>
    <dbReference type="EnsemblBacteria" id="BAJ64715">
        <property type="protein sequence ID" value="BAJ64715"/>
        <property type="gene ID" value="ANT_26890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26890"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_0"/>
    <dbReference type="OMA" id="SSIATWF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="128"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="188" mass="22748" checksum="BE89A301D315C08E" modified="2011-04-05" version="1">MTEWVSKMGLSRNRTKYDERFLIQAIREDPEKFGELYKLYVERVFRYLYSQTGNIQEAEDLTSQTFLTALESINHYRQDGHFSAWLFTIAHNKAMDHFRRKKKTIPLDEKREIPDPIHAVMQSEQSIMLRTLIRSLTEEERELLRLRFLAEMSYEEMAHFLRRNEQAVKKSLYRLLARLQRQMEDSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0K3</accession>
    <name>E8N0K3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561104.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64752">
        <property type="protein sequence ID" value="BAJ64752"/>
        <property type="gene ID" value="ANT_27260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27260"/>
    <dbReference type="eggNOG" id="COG5427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011570_0_0_0"/>
    <dbReference type="OMA" id="YYYGGHL"/>
    <dbReference type="OrthoDB" id="612537at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018746">
        <property type="entry name" value="DUF2298"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10060">
        <property type="entry name" value="DUF2298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03662">
        <property type="entry name" value="Chlor_Arch_YYY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="834" mass="93737" checksum="92535D2AE4A6364F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S7</accession>
    <name>E8N0S7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_04380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558868.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04380"/>
    <dbReference type="EnsemblBacteria" id="BAJ62472">
        <property type="protein sequence ID" value="BAJ62472"/>
        <property type="gene ID" value="ANT_04380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04380"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_4_0"/>
    <dbReference type="OMA" id="AEVCVMP"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="236" mass="26082" checksum="B38A8257137B8FF8" modified="2011-04-05" version="1">MGLRELTSGLESVRLFRGLTPQQLEWVAARAYSRTFPPGVELIVAGTPGETVYFILSGTVKIYVPQVDGTEVIVNILGPGDTVGELGVIDGGERSASVVTLERTETIWMTGEMFQEALRTIPQMNENLLRILSARVRLTTENVQAYASLDIPGRIARQLLSLAHTYGREQGGGVFIPLRLTQGDIAELVGSSRKRVNQVMVTLRREGVLTFDTEGHITLFRLKDLERMVEGRVGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U9</accession>
    <name>E8N0U9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558890.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62494">
        <property type="protein sequence ID" value="BAJ62494"/>
        <property type="gene ID" value="ANT_04600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04600"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_4_0"/>
    <dbReference type="OMA" id="QFFDRDA"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228035" evidence="1">
        <location>
            <begin position="26"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="449" mass="51158" checksum="7885E71A547A07FF" modified="2011-04-05" version="1">MKIRFFTLFSMLMLVVMVFSACAPAATPTPEKVVETVVVEKEKVVEKTVEVQKVVTANVITYNSYNGDPKPRAFDESVVKMWNEAHPEMPVEHSIIAHEDFKQAIRAYLTADPAPDVLTWFAGNRARFFIDKGLILDQTKMWEDAKLNEVYAPGFQALATYNDKKYFLPTSYYWWAIYYRKSLFAEAGIEKEPETWQDLLDACDKLNAKGITPITIGARFKWPAAAWFDYLNMRVNGPQFHIDLTDLKVPYTDPKVRKVFDYWKELIDHKCFIEDPAAYDWQEAIDPMVQGKAAMYLMGAFITDSYPDEAEADLDFFRFPIIDPNLPVGEDAPTDGYFASATARNPEGALAFMAFLGSKEVQQKAFEELGRLPTRTDVDISKATPATQKGIKLIQSADYIAQFYDRDTTPPMAEAGMDGFMRFWDDPTQIDQILADLEAERQRILSEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y9</accession>
    <name>E8N0Y9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558930.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62534">
        <property type="protein sequence ID" value="BAJ62534"/>
        <property type="gene ID" value="ANT_05000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05000"/>
    <dbReference type="HOGENOM" id="CLU_1871100_0_0_0"/>
    <dbReference type="OrthoDB" id="504558at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="15603" checksum="36A816EF126382E1" modified="2011-04-05" version="1">MPEFHQWLEQKFRQWEKEQGKAQSYYAFARYLGVSQSDLALWMIGDGLPGADDLSLIAEKLGDEVYTIMEKPRADPFLQKMVDAFPVLPVGLRERLASAAWDTRQYIQSRGLDPESVEAKKALVEIFQRYGIRFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N125</accession>
    <name>E8N125_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_05360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558966.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62570">
        <property type="protein sequence ID" value="BAJ62570"/>
        <property type="gene ID" value="ANT_05360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05360"/>
    <dbReference type="eggNOG" id="COG1243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_0"/>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="OrthoDB" id="221975at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="84"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="532" mass="60624" checksum="BBFADBBB03375938" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N165</accession>
    <name>E8N165_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561155.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27820"/>
    <dbReference type="EnsemblBacteria" id="BAJ64808">
        <property type="protein sequence ID" value="BAJ64808"/>
        <property type="gene ID" value="ANT_27820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27820"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_8_3_0"/>
    <dbReference type="OMA" id="FIKCMRN"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="128" mass="15282" checksum="5725B8C5EE018B32" modified="2011-04-05" version="1">MKIAEVSQRFGISLDTLRYYERIGLLPPVKRNGSGIREYDEQDLRWIDFIQCMKRAGLPLDSLREYVQLVQQGDETIPTRKEILQAHREQLAKRIQELQETLDMLDRKIANYENRLLMREKEMLSEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1B1</accession>
    <name>E8N1B1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">infA</name>
        <name evidence="5" type="ordered locus">ANT_28280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28280"/>
    <dbReference type="EnsemblBacteria" id="BAJ64854">
        <property type="protein sequence ID" value="BAJ64854"/>
        <property type="gene ID" value="ANT_28280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28280"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_0"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="86" mass="10049" checksum="6ADD75DE633D1AB1" modified="2011-04-05" version="1">MPMAKEEEKIQVDGTIVEALPGTQFKVRLDNGHEVLAYLSGRMRKYYIRILLGDRVRVEMSPYDLTRGRIVYRQKKTSEGIVEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1D5</accession>
    <name>E8N1D5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561223.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28520"/>
    <dbReference type="EnsemblBacteria" id="BAJ64878">
        <property type="protein sequence ID" value="BAJ64878"/>
        <property type="gene ID" value="ANT_28520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28520"/>
    <dbReference type="eggNOG" id="COG1769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044328_1_0_0"/>
    <dbReference type="OMA" id="VMESMFP"/>
    <dbReference type="OrthoDB" id="1656967at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010165">
        <property type="entry name" value="CRISPR-assoc_prot_TM1793"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019117">
        <property type="entry name" value="CRISPR-assoc_protein_Cmr3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09700">
        <property type="entry name" value="Cas_Cmr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01888">
        <property type="entry name" value="cas_cmr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="359" mass="40013" checksum="857C89182236C421" modified="2011-04-05" version="1">MSILFMQAEDVLLFRDGRPFNAKSDHEARSLFPPPPSVMQGVLRSHYLAHKNISLNDSQAIQALVGDSANPKGLRLRGPFLAWRENGRVVRYLPTPADAYPVDEKAERVVPMKAAKNPGGCVWDGATLPYLLQRPNNIITKSAPGEYLSEKALLEYLEQGREVAPVKATDLYVTERRLGIQTDPQRLSTVEGMLYEVEFIRLREDAGLVVEILEGYPDFPPQGVMRAGGEGRALRYTTLKEGEFTPLSWGYTGELPRFFKVYFATPAYFSQGWKPASWQAFFTGEVRLEAVALSRYQVLGGYDLLKKEQKPARRFVPAGSVYYFSHAGGVQLSQQVITEDGAALGFGQVMIASWKPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E1</accession>
    <name>E8N1E1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_28580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561229.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64884">
        <property type="protein sequence ID" value="BAJ64884"/>
        <property type="gene ID" value="ANT_28580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28580"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OMA" id="AWMMKGF"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="31567" checksum="2B8B1F26AC675527" modified="2011-04-05" version="1">MSAFSGSHGVFWRKTLPRAVQYFLLTLMSIYILVPIVILIFGSLKTRGQMYSHPYTPPIPPYWDNYIKILTSDIFWTMLKNSLIVTLAVTAAVLVICSLAAFVFARLDFRGKDLAFNFFTLGLMFPITIAILPVYLVIRQMSLTNSLLGIILVQTAFQLSGNILILRNFFASIPFELQDAAYIDGCTPFDFFRLILLPLARPALSAVASLTMVVSWNDLLVPLVLIDKETLWTLPLGTMQFQGQYGTDLALVAAFVALSAVPAVIFYIVAERHIVSGLTAGALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H5</accession>
    <name>E8N1H5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsA</name>
        <name evidence="5" type="ordered locus">ANT_05460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558976.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05460"/>
    <dbReference type="EnsemblBacteria" id="BAJ62580">
        <property type="protein sequence ID" value="BAJ62580"/>
        <property type="gene ID" value="ANT_05460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05460"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OMA" id="IKMLSGA"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="256"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="499" mass="54976" checksum="9DD1BE24740FE157" modified="2011-04-05" version="1">MTDTAIPRLKLEHVYKSFPGVQAVSDVSLDVYGHQILALVGENGAGKSTLMNIINGVVPLDSGKIVLDGQPVSITSPHRALELGITMIHQELALIPELTVGQNIFLGREPRRWGIGVDWKRLYAQAQRELDRLGIEVSAQATIADLSIAQRQLVEIAKALSYNARLIALDEPTSSLTSRETETLFRLVRSLREEGVALIYISHRLEEVFELADRIAVMRDGHLVAVGNAAEFTPAEVVRLMVGRELTEFFPKVPAQRGEPVLKAVNLKAGREVRGVSLELHRGEIVGLAGLVGSGRTNVARLLFGADRLEAGEIWFEGRKVQLRSPQDAIRLGIGLVPEDRKAQGLFAGQSVRYNAAAGLIQRLSRWGFIRFQAVNRIVRELVERLRVRTPHLNQKVRNLSGGNQQKVIISRWLSLNPKVLILDEPTRGVDVGAKAEIHALMSELAAQGMAILMISSELPEVLGVSDRILVMREGRIVAELTREEATQDRIMQAATGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q3</accession>
    <name>E8N1Q3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62658">
        <property type="protein sequence ID" value="BAJ62658"/>
        <property type="gene ID" value="ANT_06240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06240"/>
    <dbReference type="HOGENOM" id="CLU_192036_0_0_0"/>
    <dbReference type="OMA" id="WAYCHRA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="81" mass="9386" checksum="31D72A851FA10F51" modified="2011-04-05" version="1">MTRRTIRASEIGAFLYCRRAWWYRLQGVEPQNREVLGEGTAYHLRHGKEVWLASLIRLAGWLFLSGALILLVVGLTLYVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1U8</accession>
    <name>E8N1U8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiN</name>
        <name evidence="7" type="ordered locus">ANT_06690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559097.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06690"/>
    <dbReference type="EnsemblBacteria" id="BAJ62703">
        <property type="protein sequence ID" value="BAJ62703"/>
        <property type="gene ID" value="ANT_06690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06690"/>
    <dbReference type="eggNOG" id="COG1564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_1_1_0"/>
    <dbReference type="OMA" id="PRDKDYT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="6">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="215" mass="23824" checksum="2FFD0F395005EB26" modified="2011-04-05" version="1">MTSQRALIFVSGASCNEEALRHFRQPEDFIIAADGGAQHCLRLGWRPHVVIGDFDSLSAEILNHLEREGVLLLRYPPEKDETDLELALQYAVQRGFEVIRILCGLGGRVDQTLANLFLLGLPMLSDRDVRLEDGEVEAFLIRSEAVLEGAPGETVSLIPLSGAAQGIWTEGLRYSLHGETLYPEHSRGVSNEMISARARVRLSHGMLLCIHFHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V6</accession>
    <name>E8N1V6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559105.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06770"/>
    <dbReference type="EnsemblBacteria" id="BAJ62711">
        <property type="protein sequence ID" value="BAJ62711"/>
        <property type="gene ID" value="ANT_06770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06770"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_0"/>
    <dbReference type="OMA" id="YWAMMHK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="22"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="270" mass="30629" checksum="B2C3A0C3DA151B15" modified="2011-04-05" version="1">MSSITTDQGILHYEVYGRGRPVILLHGWLGSWGLWQETMTFLGQYYRTYALDFWGFGESGTKRNTYNVQDFISLVAQFMDQMGILSAPLIGHSMGGTVSLSVAIQYPHLAQKVVVIGSPIAGSSLALPLKFAGYRPIAWLLFTFFPLFRAAMRIASPTICKDPRFPDMMDRDLSQTTLESFLISIATLRRTDLRPRLHQIRVPVMGMYGDRDNIVHPRQWEPLKKGVPHARIERFPKAGHFIMLDEPKECMSKIKDFLDTPAEPLPPVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V9</accession>
    <name>E8N1V9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homocysteine S-methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559108.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06800"/>
    <dbReference type="EnsemblBacteria" id="BAJ62714">
        <property type="protein sequence ID" value="BAJ62714"/>
        <property type="gene ID" value="ANT_06800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06800"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047457_0_0_0"/>
    <dbReference type="OMA" id="AQEDYKM"/>
    <dbReference type="OrthoDB" id="1149455at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="296" mass="31357" checksum="1BB153F92D3160B2" modified="2011-04-05" version="1">MNSSSFFALQEGHGVVLLDGAMGTSLQQRGLPLGVPSDSWVLERPEEVLRVHEEFLAAGAQIILTNTFGSSRLRLRQAGMEEHFEIINRQAVALARRASHGCSGVWVAASLGPLGEWLEPLGALSPGQARAFYREQAQILIEAGIDALVIETQMDLQEALTAIEACFSAGNVPVVCSFSFNAQGRLIRGERPAQVAQVLEQSGVFALGVNCGSSLEGNLQALAEMREVTSLPLWFKPNAGLPTVDEAGRVAYPIAPEQMGKGAVRAVEKGAKFVGGCCGATPAHIRTIAKALGKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W9</accession>
    <name>E8N1W9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory protein Ada</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ada</name>
        <name evidence="7" type="ordered locus">ANT_28900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561261.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64916">
        <property type="protein sequence ID" value="BAJ64916"/>
        <property type="gene ID" value="ANT_28900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28900"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_0_0"/>
    <dbReference type="OMA" id="GVFCRLT"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016221">
        <property type="entry name" value="Bifunct_regulatory_prot_Ada"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000409">
        <property type="entry name" value="Ada"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from methylphosphotriester" evidence="4">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000409-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="356" mass="39406" checksum="74FB54F55F0ADC76" modified="2011-04-05" version="1">MMRSMMAQLQDEETLWQAVMARDAAWDGKFVFAVRSTGVYCRPSCPARRPRREQVRFFAAPAEARAAGFRPCKRCAPDEPIPPTQAWVLEVCRLLEEAGRPLPLNELSRAVGISPHHLTREFKAALGVTPRQYGEALRRQALRQELRAGESVTAAVYAAGYNSAARMYASGAATLGTTPNHYRMGGMGMDIAYTLVDSPLGRLLIAGTSRGICFLSMGDEDDPLLEALRREFPQAQIRPAGEDMRAWVSEVLAYLRGELPDVSHLPLDVRATAFQLRVWEELRRIPPGETRTYAQVAEALGNPKAVRAVARACATNPVSLVTPCHRVVRTDGSLAGYRWGVGRKRRLLEQEKHLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Y5</accession>
    <name>E8N1Y5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrite reductase (cytochrome; ammonia-forming)</fullName>
            <ecNumber evidence="2">1.7.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nrfA</name>
        <name evidence="10" type="ordered locus">ANT_29060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:13089"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c-552 family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561276.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29060"/>
    <dbReference type="EnsemblBacteria" id="BAJ64932">
        <property type="protein sequence ID" value="BAJ64932"/>
        <property type="gene ID" value="ANT_29060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29060"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035040_1_0_0"/>
    <dbReference type="OMA" id="EMVILWA"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042279">
        <property type="term" value="F:nitrite reductase (cytochrome, ammonia-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00548">
        <property type="entry name" value="NrfA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003321">
        <property type="entry name" value="Cyt_c552"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30633">
        <property type="entry name" value="PTHR30633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02335">
        <property type="entry name" value="Cytochrom_C552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000243">
        <property type="entry name" value="Cyt_c552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="429" mass="47853" checksum="1753A460D055E72C" modified="2011-04-05" version="1">MKKFTGTTLILTGIIVVLSALLIGVLIFLRNQPAPQRGVMPVVKIAAMEPDSSIWGQNFPNQYSTFMMTESNNTATTYGGSDPYEKLNKDPMLKTLFAGNPFSKGYGEDRGHANALTDVENTPRLSDKTPGTCYSCKSADNPKLWSEMGMAEYDKTPFKQLGEKINHPIGCANCHDAETMRLIVTNPALEEALKEQGKDWRTFSRQEMRSLVCANCHVEYYFTKEGNYLTFPWEKGTNVEAMEAYYNEIGFFDWKHADSGANMIKMQHPDYEMYTANSTHYKAGVACADCHMPYMRDGAAKFSSHNVKSPLLDPARSCGTCHTDVNYVVERVNIIQKNVYDTMQNTEKALVSAINAIKTASENPNADQSKLEEARKLHRAAQLRWDYVAAENSMGFHNPTEALRILAAATDLARQAELTALQAVQVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z7</accession>
    <name>E8N1Z7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561288.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29180"/>
    <dbReference type="EnsemblBacteria" id="BAJ64944">
        <property type="protein sequence ID" value="BAJ64944"/>
        <property type="gene ID" value="ANT_29180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29180"/>
    <dbReference type="eggNOG" id="COG4334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133265_1_0_0"/>
    <dbReference type="OMA" id="RPVTIWI"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016888">
        <property type="entry name" value="UCP028498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10012">
        <property type="entry name" value="DUF2255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="132" mass="15111" checksum="51C7120DD09D4A5B" modified="2011-04-05" version="1">MSGWTTEELEVIGKAEELHLAPQREDGTAGKFVTIWVVRVDNDLYVRSWRGQQSRWYRQAQAHLAGRIRAGKIEKDVLFVEEDDPAINAQVDQAYRQKYRRYLSYAEAMASLPARTTTLKLIPRETDTAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N219</accession>
    <name>E8N219_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29400"/>
    <dbReference type="EnsemblBacteria" id="BAJ64966">
        <property type="protein sequence ID" value="BAJ64966"/>
        <property type="gene ID" value="ANT_29400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29400"/>
    <dbReference type="HOGENOM" id="CLU_3113960_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="50" mass="5183" checksum="41D1667C0C526BC4" modified="2011-04-05" version="1">MDDLRAEDASPAGIILPPPQTSRAALSGRKNQTGRRSLNALPGALQGQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N274</accession>
    <name>E8N274_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29950"/>
    <dbReference type="EnsemblBacteria" id="BAJ65021">
        <property type="protein sequence ID" value="BAJ65021"/>
        <property type="gene ID" value="ANT_29950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29950"/>
    <dbReference type="eggNOG" id="ENOG5033WIA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637204_0_0_0"/>
    <dbReference type="OMA" id="FRENEMP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="430" mass="50352" checksum="5B88DD76E43950B8" modified="2011-04-05" version="1">MEVMIARIRRKEFGNGGEVMTENKETSLPGNGNVMEYQPDYFVDRKGELDLVRNMLTGHEKAGSRVILVEGERGMGKTWLALHLHRTVLTKSERVKSLLVLMVPPSWAKSSEREYCVPSLENADLKQTLQELLRWMAEGLGVQLPHEPALEEISDRILRHVEGDEFTRYWLLLDSVYECRWEFVELLENVFLMRFMALPNAYLWASGRGRPYPWKIPETSRAVVSSLALFNEDSLRDQLNKFMRVAEKELENRVKWVAELGKGIPLLSQTLVQTQTKEEGLKKAVALLLEVIPESRREHLRRVLERLSVLDGFREEEMAYLLEKDGQKVPLDEVRRIRDELLRVSLVRWEKSKFVMDQPLQEILQEYMKACNPEEWERLNQCMIDYYEDLRDKPAFKNYQKYLDEKILFYREAMGKEQKSNPTSAVHSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G9</accession>
    <name>E8N2G9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_07410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559168.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62775">
        <property type="protein sequence ID" value="BAJ62775"/>
        <property type="gene ID" value="ANT_07410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07410"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_3_0"/>
    <dbReference type="OMA" id="YGYLGIM"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="345" mass="37512" checksum="45B41CA9E2F64F68" modified="2011-04-05" version="1">MKQKVFNALIGIGVALLLGAVLLILQGYNPLETYQALFEFSLFGYYPFATTLRNAVPLVLPGLSAAIAFASGVVNLGQPGQLVMGALFATVGGLYLDLPPALMIPVLALLAMLGGMLWAGIAALLRRFFDMSEFIVTLMLNMIADYFTAWAITEPFKDPTAFSPMTPQITQNGWLPKWGEFNSMILFMLAAVLVSWFVFNRWKAGYEWRITGQNALFARLGGCDINRNFMAVMLMTGALAGLAGGLVVMGGTHRFIRGLGANYAWDGVMIAIVANNGILATFLYGLFFSAIQTGALGMELITSVPNEISQVLQAVLVLVIVASREYLNTLVEQISARRRAREART</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S0</accession>
    <name>E8N2S0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III delta subunit</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">holA</name>
        <name evidence="2" type="ordered locus">ANT_30440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561411.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30440"/>
    <dbReference type="EnsemblBacteria" id="BAJ65070">
        <property type="protein sequence ID" value="BAJ65070"/>
        <property type="gene ID" value="ANT_30440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30440"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044694_2_2_0"/>
    <dbReference type="OMA" id="TWLWVKL"/>
    <dbReference type="OrthoDB" id="1860432at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="37473" checksum="0869D4CFC764D9A9" modified="2011-04-05" version="1">MSEKPVVYVLHGNDVHAMQAFIHTLREKLGDPAVADLNLTRLDGRTASEDDIFNAAGAMPFLAERRLVILTHPFTRLTAESARQRFCQRLETLPETTALVLVIEDIIERRSWVHFPPKHWFRAWMEKAGKRVHYHLCTLPDLSAMPAWIQKEARSLGGQFTAEAAAELARHVGNDTQTARQEIEKLLTYVNFQRAVELEDVAELTAQGGEADLFAMMDAIAEGNARLAQNLLHRLLEEEDELSLFGMIVRQFRLLLLARELLDEGKGVADFLQAGISTSQFVAEKSLRQARRFSMAQLEEIYRTLYEMDGAVKTSNTDLPTALDTFIVALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U2</accession>
    <name>E8N2U2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative plasmid maintenance system killer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561433.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30660"/>
    <dbReference type="EnsemblBacteria" id="BAJ65092">
        <property type="protein sequence ID" value="BAJ65092"/>
        <property type="gene ID" value="ANT_30660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30660"/>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155111_1_1_0"/>
    <dbReference type="OMA" id="INDQWRL"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="93" mass="10933" checksum="9A04CA54B6CDDBA7" modified="2011-04-05" version="1">MIKSFRDRSTESLFHGERHPSLPPNLQRIALRKLLILDAAADLDDLRVPPGNHLEKLRGDREGQYSIRINDRYRLCFVWQDGDAYEVEITNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U8</accession>
    <name>E8N2U8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561439.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30720"/>
    <dbReference type="EnsemblBacteria" id="BAJ65098">
        <property type="protein sequence ID" value="BAJ65098"/>
        <property type="gene ID" value="ANT_30720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30720"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_11_2_0"/>
    <dbReference type="OMA" id="FAEPRVY"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="397" mass="44491" checksum="4F62DFEEA1A8BA70" modified="2011-04-05" version="1">MERIPPEQAGFSSVRLQRITSFFQSLVDRQVIAGVDALVARRGRVAYRQCVGFADLESAKPLAEDALYRIYSMSKPITSVAVMMLFEEGAFHLFDPVARYIPALGEVKVYQPRSGGADFDLVPPKRPITIHDLLTHTAGLSYGFDEHSYIDDLYRKMVWQRLEKDPEITLGTLVEEIAKIPLAFHPGTSYRYSTAIDVLGYLVEVVSGKPFDVFLRERIFEPLGMNDTDFWAPPEKAARLANLYGPAEGGGLKVIQTMENFLRKPSVPSGGGGLVSSTADYFRFAQMMLNRGEWQGVRLLGRRTVEWMWMNHLPEGLRLPDDPACGFGLGGSVVVDAARHWHMCSPGNWGWGGAANTWFFLDPSEDLLAMIMLQYMPGFTIPFHHTFANLVYQALND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N331</accession>
    <name>E8N331_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_31570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31570"/>
    <dbReference type="EnsemblBacteria" id="BAJ65181">
        <property type="protein sequence ID" value="BAJ65181"/>
        <property type="gene ID" value="ANT_31570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31570"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507881_0_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="157"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="231"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="479"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="609" mass="68587" checksum="4F3AE9B4B222111D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N335</accession>
    <name>E8N335_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_31610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561525.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31610"/>
    <dbReference type="EnsemblBacteria" id="BAJ65185">
        <property type="protein sequence ID" value="BAJ65185"/>
        <property type="gene ID" value="ANT_31610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31610"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588812_0_0_0"/>
    <dbReference type="OMA" id="FQSWQTV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="464" mass="50091" checksum="60082960CD6319CE" modified="2011-04-05" version="1">MGEGHPHRLITRLWGRARAFAEDRLLRRVVRNSAYLFISNVIAAVLGIVTANLLGASVFGTLGILTGFVTDVNRLFSFRMNDVVVRYMGEALAQRDKARAAAVVKAAALIEGAASLFAFLALLALAPVGARYFAKDASLTPLFILYGGSILANLVNETSTGVLQVTGHFRSQALINLAQSVLVALIIVHAALTGGGLLEVLWAYLLGKVILGLGPVGLALYWAGHVLGRDWWRASFALLPPWKELVRFGISTNFSGTINLIARDSEVPLVGFFFGPQIAGYYKIALQVVNLLIMPINPFIGTTYPEITRAWAAREWMRLKNLLRRVSFIAGGWSVLAGAGLALFGEALLFSPIALFGRTFQLYKAEYLPALPVLMILLVGYGVANTFFWSRLLLLSQGKADQALRISFLAMLGKLALAVLFLPAAGYLMEAVFLSGYFIVSTGWMVALGLRGLQAAAQDGEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E3</accession>
    <name>E8N3E3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559348.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62957">
        <property type="protein sequence ID" value="BAJ62957"/>
        <property type="gene ID" value="ANT_09230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09230"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432625_0_0_0"/>
    <dbReference type="OMA" id="WGRYTLL"/>
    <dbReference type="OrthoDB" id="410691at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="619" mass="69812" checksum="34DB6E2F721C44D1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I3</accession>
    <name>E8N3I3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="5">RF MTase</shortName>
            <ecNumber evidence="5">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemK</name>
        <name evidence="5" type="synonym">prmC</name>
        <name evidence="8" type="ordered locus">ANT_09630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559388.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09630"/>
    <dbReference type="EnsemblBacteria" id="BAJ62997">
        <property type="protein sequence ID" value="BAJ62997"/>
        <property type="gene ID" value="ANT_09630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09630"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_1_0"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="6">
        <location>
            <begin position="112"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="124"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="287" mass="31613" checksum="53F916554A4782AD" modified="2011-04-05" version="1">MKNSPTLGAWLQQARETFAQQSDTAGIEVQVLAAHVLKRPRAWIAAHPETLLSDEQASHLNTLLGRLLEGVPLPYLTGKQEFFGLEFEVSPAVLIPRPETETLVEAALQWLKRFPERNRVADVGTGSGCIAVSIAYHMPNVRVLATDFSHEALKVAQRNVNRHGVSDRVQLIQCDLLSACAGMFDLVCANLPYIPTSALDETPPARFEPIAALDGGESGWEKIKALLQDAPRWLVPGGCILLEIQWDQGQTVSEIARGIFPAAEIQILQDLAHLDRVVLIQTTREKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3T3</accession>
    <name>E8N3T3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559487.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10630"/>
    <dbReference type="EnsemblBacteria" id="BAJ63097">
        <property type="protein sequence ID" value="BAJ63097"/>
        <property type="gene ID" value="ANT_10630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10630"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111589_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="178" mass="20921" checksum="A16B24DCC5FFE2D7" modified="2011-04-05" version="1">MTETSEVREDLLSRVVVRHLHEEDLPALEWEGEYTHFRRMYADAYQRMKRGLTLMWGAELQGVGIIGQVFVQFLCDRPELCNGVDRAYLYAFRVRAPYRSRGVGALILSIVEEDLRRRGFRYVTLNVARDNPRAQAFYERHGYHVVAPEPGRWQYINHLGRLVEVVEPAWRMEKSLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N401</accession>
    <name>E8N401_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secG</name>
        <name evidence="10" type="ordered locus">ANT_11310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559553.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63165">
        <property type="protein sequence ID" value="BAJ63165"/>
        <property type="gene ID" value="ANT_11310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11310"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_6_2_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="73" mass="7819" checksum="AE56F07AF0D3448B" modified="2011-04-05" version="1">MQTYLDIALIITSIALIISVILQSKGVGLGGLTGSDSSTVFTARRGIEKTLFYVTIGLSVLFFILILTVTIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N407</accession>
    <name>E8N407_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11370"/>
    <dbReference type="EnsemblBacteria" id="BAJ63171">
        <property type="protein sequence ID" value="BAJ63171"/>
        <property type="gene ID" value="ANT_11370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11370"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096865_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="28661" checksum="64E7EA0643844958" modified="2011-04-05" version="1">MNFPLHRMEFLLRQWLEGWSGSSAEDFLLHFLQELERILPQVLASQSSDLLEEMNVLLIVGISPQVRAHFQEKSPVLNDLLHLLQQVAREQGMRVHFSIEFVEDPRLKLGEVWVDWEMPEQGSSTRAMPNPLGVSLRETGKRAYLIVPGGNLFPLEQSVVNVGRMKDNHLVLDDPRVSRHHAQIRRSPEGFILFDLNSTGGTMVNHLPVHQWTLRPGDVISLAGVTLVYGEEEEQNSFDEDTTDTATLPKGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N418</accession>
    <name>E8N418_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_11480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559570.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63182">
        <property type="protein sequence ID" value="BAJ63182"/>
        <property type="gene ID" value="ANT_11480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11480"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053649_0_0_0"/>
    <dbReference type="OMA" id="AWEKNWG"/>
    <dbReference type="OrthoDB" id="884913at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="375" mass="43881" checksum="76D05512FEC3BB67" modified="2011-04-05" version="1">MLTIQQVDTRSREQVHRFIQFHYDLYRGTPQWVPPFYSDIRLMLDREKHPFYEHSDGDFFLALRGKEVVGRIAILENRPFNEYHQCKKAQFYLFDCINDLEVARALFDRAAEWCKARGLTEIVGPKGLSAFDGYGIQVEGFEHRQMMTMMNYNFDYYPKLMEALGFEKEVDFVSAYINRENFQLPDKMREVARRVIERGKFKVVNFRNKKELVAWAPKIGEAYNKAFVNNWEYYPLSPREVKFVLDNLLMVAVPELIKIITYNEDVVGFLFGFPDISAALQRQGGRITPWGLVDFMLEMKRTKFISLNGVGVLPEYHGRGGNVLLYAEMAKFLENSQFTEGELTQMAETAVQIRKDILVAGSKPWKNHRVYHKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N425</accession>
    <name>E8N425_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559577.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11550"/>
    <dbReference type="EnsemblBacteria" id="BAJ63189">
        <property type="protein sequence ID" value="BAJ63189"/>
        <property type="gene ID" value="ANT_11550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11550"/>
    <dbReference type="HOGENOM" id="CLU_514512_0_0_0"/>
    <dbReference type="OMA" id="WRIASNF"/>
    <dbReference type="OrthoDB" id="10476at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="529" mass="60136" checksum="E1FB3FA53EECC780" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N441</accession>
    <name>E8N441_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_11710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559593.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63205">
        <property type="protein sequence ID" value="BAJ63205"/>
        <property type="gene ID" value="ANT_11710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11710"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_0"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="27443" checksum="B45E8094F49F51E6" modified="2011-04-05" version="1">MAEERVQKILARAGYGSRRACEELILAGRVKINGQTAVLGSKADPSRDQILVDGQKIPLQPPPVYIMLHKPQGVLSDVEVHKDPRPTVRDLVPVEGHLFSVGRLDYESEGLILLTNDGELANRLTHPRYGHEKEYRVLVGTRPDERQLEAWRHGVVLEDGYRTAPAQVRVEGVAGKGAWLRVILREGRKRQIREMGRLTGLPVLRIIRIRIGSLLLGDLKPGEWRYLTPQEVRLLKAGVSSSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E2</accession>
    <name>E8N4E2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559694.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63306">
        <property type="protein sequence ID" value="BAJ63306"/>
        <property type="gene ID" value="ANT_12720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12720"/>
    <dbReference type="HOGENOM" id="CLU_2068207_0_0_0"/>
    <dbReference type="OrthoDB" id="2053329at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="118" mass="13656" checksum="D23F361B3FA60AF6" modified="2011-04-05" version="1">MDEKITIIEGPTPVFEAIDDGWALGLHESAGMYETALTRVRTFNGNALVERCHKAWSRQEHIYLHYRNRLGMEERAPIFAARNVTTPEGDVLLLWCRLKPEDIEEEPDFDLPDDEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4H1</accession>
    <name>E8N4H1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_13010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559723.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63335">
        <property type="protein sequence ID" value="BAJ63335"/>
        <property type="gene ID" value="ANT_13010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13010"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691957_0_0_0"/>
    <dbReference type="OMA" id="GKFWGVV"/>
    <dbReference type="OrthoDB" id="1165704at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="PTHR12778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="5"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="398" mass="43608" checksum="1B96EB6E6D48E178" modified="2011-04-05" version="1">MKHSRFFRFSLFALIYFAEGAILSYFTALNGIYLLSFDVSMTQIGLIGSIALLPFVLKIFLGLISDRFNLFHLGHRKPYILIGLIVQFVCLLVVPHIHPGQQFALFAFLAFLLMSGQALYDTSTDGLALDTTAPEEEGTVQGIMVGGRALGVVLISSIIGWVAQNASWMWMFYLLALLTLIPLPLVLSLRESERTAQQRFTWQGFSAFKSREVIALGILGALYSMIINAANQIVNPFLQQTFQISVSFAGFTTTIWGIGVILGGLLGGLLTDRLGQSRSVIAAVLLSLTSIFGLSLTPNAFVALFLVMVFGFAFGYYETVYFATSMRVTDPRIAATMFAILMGIANLGTGIGLALSGSLSDWIGFRNTFIVFALLNLLAFPLLPWVFPGRVMQKVKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I1</accession>
    <name>E8N4I1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559732.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13130"/>
    <dbReference type="EnsemblBacteria" id="BAJ63345">
        <property type="protein sequence ID" value="BAJ63345"/>
        <property type="gene ID" value="ANT_13130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13130"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_1_0"/>
    <dbReference type="OMA" id="HRILFFW"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="227" mass="26272" checksum="3CAD319F21982C03" modified="2011-04-05" version="1">MNLTVLIPVYNEIQTIAEIIRRVKAVQLASEILIVDDGSTDGTRDYLITLKDDPIVRVILHERNQGKGAAVRTGIQQARGDWIIIQDADLEYDPRDYPVLLQPVEEGIADVVYGSRFLGGARRPILFWNMVANKILTFITNILYNNILTDMETGYKLFRRDIALQIPLHARGFEFEPEFTAKLLKRKVRIYEVPIRFNPREYSEGKKIKMKDAFIAVWTLLKYRFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J0</accession>
    <name>E8N4J0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">argS</name>
        <name evidence="11" type="ordered locus">ANT_13220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559741.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63354">
        <property type="protein sequence ID" value="BAJ63354"/>
        <property type="gene ID" value="ANT_13220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13220"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_0"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="473"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="587" mass="66873" checksum="6B6DC6AFB8FC8372" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S5</accession>
    <name>E8N4S5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559821.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63439">
        <property type="protein sequence ID" value="BAJ63439"/>
        <property type="gene ID" value="ANT_14110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14110"/>
    <dbReference type="HOGENOM" id="CLU_2912329_0_0_0"/>
    <dbReference type="OrthoDB" id="2197460at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="61" mass="7183" checksum="9C90729BFDB7CC39" modified="2011-04-05" version="1">MANPSEPKTETIAETENYIAWKADEPDGETTYHIELNNVTVHFFEEEWEEFLQLAKLLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V1</accession>
    <name>E8N4V1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14370"/>
    <dbReference type="EnsemblBacteria" id="BAJ63465">
        <property type="protein sequence ID" value="BAJ63465"/>
        <property type="gene ID" value="ANT_14370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14370"/>
    <dbReference type="eggNOG" id="COG3872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038140_0_0_0"/>
    <dbReference type="OMA" id="LFQYHGA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010787">
        <property type="entry name" value="DUF1385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07136">
        <property type="entry name" value="DUF1385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="32794" checksum="94D2753DA4F2DD85" modified="2011-04-05" version="1">MPAYGGQALIEGVLMRSRYVAVAAMRTPEGQITLHVEPLSNIYRSKFWQLPFVRGVIALWDALGLGMRFLTISANLQAPEEEKLEGKSAILTVGVSLILAIGLFFLIPAGIAQFLQNLLSINAFASNLIEGVVRLIFVIGYIWGIGQIPEIQRVFAYHGAEHKTINAFEGEAELTPEKVREYPLEHPRCGTSFLLTLIIVSIIVFTLLGDLTPFWRIATRVIFLPVLAGIAYEYIRWSANHIENPLVKSLIQPNLALQRLTTREPDPSMLQVAITAFTEMLRLEKEYSQSQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V5</accession>
    <name>E8N4V5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F420-0:gamma-glutamyl ligase</fullName>
            <ecNumber evidence="9">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_14410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559851.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63469">
        <property type="protein sequence ID" value="BAJ63469"/>
        <property type="gene ID" value="ANT_14410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14410"/>
    <dbReference type="eggNOG" id="COG1478">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051152_1_1_0"/>
    <dbReference type="OMA" id="KHGFVCA"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043773">
        <property type="term" value="F:coenzyme F420-0 gamma-glutamyl ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="255" mass="28084" checksum="8CF2616BE6874ECD" modified="2011-04-05" version="1">MSLQVLPISGIPEIKTGDVLSEIILKALEENNLSLQDEDILVLAQKIVSKAEGRFVNLTTVTPSAKAYEYAEITQKDPRFIELVLRESRSVLRCRLGTIIVEHRNGFVCANAGIDHSNVRGPWGNSEDWVLLLPEDADSSARVIRDQVFQKTQKRIGVMIIDSHGRAWRMGTVGVAIGLAGVPGLVDLRGKPDLYGYRLRITMIGAADELAAAASLVMGQADEGTPVVLVRGFPYPLRESSIQELIRPKELDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y5</accession>
    <name>E8N4Y5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNase</fullName>
            <ecNumber evidence="1">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559881.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63499">
        <property type="protein sequence ID" value="BAJ63499"/>
        <property type="gene ID" value="ANT_14710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14710"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_0"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="266" mass="30012" checksum="BC7E7D3CF83F9D63" modified="2011-04-05" version="1">MNKAYLADTHCHLNFNTFESDLEEVLERAFETGVQKILVPGIDVETSIRAVEIAQQYSPQVFAAVGIHPNSAGDCWSQTAFSEIVELSKAPWVVAIGEIGLDYYRNYTPANVQREAFEAQLELSEKRGLPVVIHNRKAEDDLLQILQTWVSAKNLSKPSGVWHSFEGPLELAHQVIELGFYLGVSGPITFKNADEKKRVVRAIPVERLLIETDSPYLTPHPHRGKRNEPMFVSLVAEELANQFNLPLTEIWQITTRNATSLFLWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N537</accession>
    <name>E8N537_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmB</name>
        <name evidence="5" type="ordered locus">ANT_15230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559933.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15230"/>
    <dbReference type="EnsemblBacteria" id="BAJ63551">
        <property type="protein sequence ID" value="BAJ63551"/>
        <property type="gene ID" value="ANT_15230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15230"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_0"/>
    <dbReference type="OMA" id="KRIWRPN"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="60" mass="6864" checksum="8EDC9466FD8B1844" modified="2011-04-05" version="1">MAKCENCGKKTVFGHRRSFSMRATNRAFRPNLQKVLVIENGRKVHKVLCTKCIRTMVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N561</accession>
    <name>E8N561_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ligA</name>
        <name evidence="12" type="ordered locus">ANT_15470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559957.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63575">
        <property type="protein sequence ID" value="BAJ63575"/>
        <property type="gene ID" value="ANT_15470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15470"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_0"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
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        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF50249"/>
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        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="596"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="34"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="674" mass="75212" checksum="4DF475D4C5B19AE9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N573</accession>
    <name>E8N573_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="14">IOR</shortName>
            <ecNumber evidence="3 14">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">iorA</name>
        <name evidence="17" type="ordered locus">ANT_15590</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14 15">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="3 14"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559969.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15590"/>
    <dbReference type="EnsemblBacteria" id="BAJ63587">
        <property type="protein sequence ID" value="BAJ63587"/>
        <property type="gene ID" value="ANT_15590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15590"/>
    <dbReference type="eggNOG" id="COG4231">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_017727_0_0_0"/>
    <dbReference type="OMA" id="IGDSTFM"/>
    <dbReference type="OrthoDB" id="342322at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03336">
        <property type="entry name" value="IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAJ63587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="609" mass="66674" checksum="D08FA440AE07B3C6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C8</accession>
    <name>E8N5C8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560022.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16160"/>
    <dbReference type="EnsemblBacteria" id="BAJ63642">
        <property type="protein sequence ID" value="BAJ63642"/>
        <property type="gene ID" value="ANT_16160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16160"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_0_0_0"/>
    <dbReference type="OMA" id="PLPIYCD"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="155" mass="16724" checksum="56064EC8F1681BE0" modified="2011-04-05" version="1">MHPLAEKVQQALNALGYSGNVQELPASTRTALEAAQALNCEIGQIVKSLVFIFSGNHQPILLLVSGKNRVDEAKVGFVLGDEIRKATAQEVQQITGFPIGGVPPIGHLQILPVIFDEDLLHFEIVWAAAGTPNSIFPISPTLLRDITHARVMSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D8</accession>
    <name>E8N5D8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative glutamate synthase</fullName>
            <ecNumber evidence="16">1.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">ANT_16260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.-.-" evidence="16"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560032.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16260"/>
    <dbReference type="MEROPS" id="C44.003"/>
    <dbReference type="EnsemblBacteria" id="BAJ63652">
        <property type="protein sequence ID" value="BAJ63652"/>
        <property type="gene ID" value="ANT_16260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16260"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_0"/>
    <dbReference type="OMA" id="TVFRLQH"/>
    <dbReference type="OrthoDB" id="5568at2"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAJ63652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1546" mass="169740" checksum="6E95A2F10D367B4F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G6</accession>
    <name>E8N5G6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560059.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16540"/>
    <dbReference type="EnsemblBacteria" id="BAJ63680">
        <property type="protein sequence ID" value="BAJ63680"/>
        <property type="gene ID" value="ANT_16540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16540"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2033248_0_0_0"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="72"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="121" mass="13730" checksum="946CB3FDAFD6EE77" modified="2011-04-05" version="1">MRTSNRPKIKETKKRFPFTLLLSGIGLILIGFLMWLALDNSNKQAVKSTPDLGIPFPNIQRVSLDEAKRAFDSQSAIFVDVRDSNSYAQQHIKGAINIPLGVFESHLDELPKDRWIILYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R4</accession>
    <name>E8N5R4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="4">2.7.8.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560156.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17520"/>
    <dbReference type="EnsemblBacteria" id="BAJ63778">
        <property type="protein sequence ID" value="BAJ63778"/>
        <property type="gene ID" value="ANT_17520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17520"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1193565_0_0_0"/>
    <dbReference type="OMA" id="WSAKEST"/>
    <dbReference type="OrthoDB" id="1542506at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="3">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="115"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="244" mass="28355" checksum="4617AF11C6E93B77" modified="2011-04-05" version="1">MSILYVLIHEVDEGQAFWEKEGEKFLSPQERERLTSLRFQKRRQEWLHGRWVAKHLIQRVLSDFGELTLSEISIENRADGSPWVFVKGEEVQGELSISHREGWACAAFSQNTEISLGIDVEKIEKRDPAFYMDYFTDREKVNRALISEMSEEMYYTFLWSAKEAVLKALKLGLRIDTRKIEILLGGFDTISRSFACSWFSISIQVLGVGENWTGFGYIREQFVMTLACHGIKKSEPVMIQEIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5X4</accession>
    <name>E8N5X4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560216.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63838">
        <property type="protein sequence ID" value="BAJ63838"/>
        <property type="gene ID" value="ANT_18120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18120"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_0_0_0"/>
    <dbReference type="OMA" id="QRPGHVP"/>
    <dbReference type="OrthoDB" id="920668at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="167"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="32294" checksum="E4CD431D2032A09B" modified="2011-04-05" version="1">MKSIRDLIQTEELDQILGNPEVVIVDCRFDLFQTEWGREQYRHSHIPGAYYAHLDEDLSGVRTPQTGRHPLPETEAFVRLLSAWGVTPNSLVVAYDQNGGAFAARLWWMLRYWGHERACVLDGGWEKWIRERRKTSTEIPAPSKGTPWLTPKNDWLISTEEMASILGNNQWKIIDARAPQRYSGEEEPIDPVAGHIPGALNRFHGFNLAPDSTFLPPDTLRQQFLELLGETSPDHTIVYCGSGVTSCHHLLAMSIAGLGMGKLYAGSWSEWIRDPNRPIRRGNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z4</accession>
    <name>E8N5Z4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560235.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63858">
        <property type="protein sequence ID" value="BAJ63858"/>
        <property type="gene ID" value="ANT_18320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18320"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_0"/>
    <dbReference type="OMA" id="HEVWEAC"/>
    <dbReference type="OrthoDB" id="255525at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="121" mass="14133" checksum="574508BF5AA163FE" modified="2011-04-05" version="1">MMKIMLVDDDRTMQAILKTLLEMDKHQVVLWDGTSESDIFAQIVQEMPDLILLDYYLRDRNGIEIVKQLRQEPQTSHIRVIMTSGQYLRDECLEAGADAFLLKPYMPDELLRLLHQVQQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N613</accession>
    <name>E8N613_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Histidine ammonia-lyase</fullName>
            <ecNumber evidence="3 6">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hutH</name>
        <name evidence="8" type="ordered locus">ANT_18510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="3 6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63877">
        <property type="protein sequence ID" value="BAJ63877"/>
        <property type="gene ID" value="ANT_18510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18510"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_4_0_0"/>
    <dbReference type="OMA" id="CAPQVAG"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="515" mass="55967" checksum="8566AC8D2DCD27BA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N645</accession>
    <name>E8N645_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">clpP</name>
        <name evidence="4" type="ordered locus">ANT_18830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18830"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="BAJ63909">
        <property type="protein sequence ID" value="BAJ63909"/>
        <property type="gene ID" value="ANT_18830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18830"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_4_0_0"/>
    <dbReference type="OMA" id="GFKRQDP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="23706" checksum="D85178C422B380F6" modified="2011-04-05" version="1">MIYEVRQGADCKGVTMRITNGIASEFSPAVTSGISDLNALLLRNRIIYLGTAIDDKVANNIVAQLLFLSNEDREAPIQMYINSPGGQVYAGLAIYDAMQIIPNPISTLAVGVTASFGTVLLAAGTKGMRYALPNATIHMHQPLGGAQGQATEIEIQAKEILRLKARLNQILAAHTGQTVETIQRDTERDRYMDAHQAMEYGLVDHIMEVPAFKRLPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N647</accession>
    <name>E8N647_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560288.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63911">
        <property type="protein sequence ID" value="BAJ63911"/>
        <property type="gene ID" value="ANT_18850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18850"/>
    <dbReference type="eggNOG" id="COG2152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046648_3_0_0"/>
    <dbReference type="OMA" id="KYYMIWG"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="305" mass="34591" checksum="5B5B889CF6031919" modified="2011-04-05" version="1">MKLNRHPNPVLLPDPQSPWECYNVFNPGVLYANGMFHMVYRAQGLDWVSRLGYAVSADGIHWNRLKNPIMEPASPEESRGLEDPRIVEIEGTYYMTYTAYGSVYKGSGQPTHAGGGILPMIARSQNLITWERIGPIVVGEDNKDHVLFPRKIGGKYVALHRRWPKVWIAYSDDLIHWPSDQMFPIYGPRPENPWDSRSVGNNGVPIETEHGWIVLNHAYDENKVYKIGVVLLDLDDPTKVIHRPKEPIFWPEELWELRGDVPNVVFSCANPVVHDTVYVFYGGGDHVIGLATCALSELVDYARFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N687</accession>
    <name>E8N687_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63951">
        <property type="protein sequence ID" value="BAJ63951"/>
        <property type="gene ID" value="ANT_19250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19250"/>
    <dbReference type="HOGENOM" id="CLU_2366739_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="95" mass="10911" checksum="898AD7D5076B648E" modified="2011-04-05" version="1">MRRSLERYTIPCTQCQAGQMHQHFITYFTWLGDELITVPDFPAWICDVCGHREYDPAALNQLSLILSPNAGRPVSRSRGIPQRKTDKKGQRPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A4</accession>
    <name>E8N6A4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_19420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560341.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19420"/>
    <dbReference type="EnsemblBacteria" id="BAJ63968">
        <property type="protein sequence ID" value="BAJ63968"/>
        <property type="gene ID" value="ANT_19420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19420"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442583_0_0_0"/>
    <dbReference type="OMA" id="WERSPAM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228204" evidence="6">
        <location>
            <begin position="29"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="617" mass="67232" checksum="18365E347843C8DE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C0</accession>
    <name>E8N6C0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560357.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19580"/>
    <dbReference type="EnsemblBacteria" id="BAJ63984">
        <property type="protein sequence ID" value="BAJ63984"/>
        <property type="gene ID" value="ANT_19580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19580"/>
    <dbReference type="HOGENOM" id="CLU_1270123_0_0_0"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="217" mass="25019" checksum="491198D8D55A8B1E" modified="2011-04-05" version="1">MFWKKTFAFLAIFVLVSIFLGLATPDLSSAQTVPTMAPTTVVPPPEEPVPTPKSKGAPLYCVKAPLSKEVEVELSLLRFPETRNKDIWGGVINPPGTACDEAVELVCKIPVRYLPQRSQLNYWREALEVRQYVKGVVDDSQSCRPKKVYFELTWYERWVHDKMPERFGFFWFNPNKKEWQSCEDVSFEPEVGKYGRISCSTLEWGYFTLGWKPPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6F3</accession>
    <name>E8N6F3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mvaD</name>
        <name evidence="10" type="ordered locus">ANT_19910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <reference evidence="12 13 14" key="2">
        <citation type="journal article" date="2019" name="ACS Chem. Biol." volume="14" first="1767" last="1779">
            <title>Substrate specificity and engineering of mevalonate 5-phosphate decarboxylase.</title>
            <authorList>
                <person name="Thomas S.T."/>
                <person name="Louie G.V."/>
                <person name="Lubin J.W."/>
                <person name="Lundblad V."/>
                <person name="Noel J.P."/>
            </authorList>
            <dbReference type="PubMed" id="31268677"/>
            <dbReference type="DOI" id="10.1021/acschembio.9b00322"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560388.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="PDB" id="6N0X">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.44 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-326"/>
    </dbReference>
    <dbReference type="PDB" id="6N0Y">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-326"/>
    </dbReference>
    <dbReference type="PDB" id="6N0Z">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-326"/>
    </dbReference>
    <dbReference type="PDBsum" id="6N0X"/>
    <dbReference type="PDBsum" id="6N0Y"/>
    <dbReference type="PDBsum" id="6N0Z"/>
    <dbReference type="SMR" id="E8N6F3"/>
    <dbReference type="STRING" id="926569.ANT_19910"/>
    <dbReference type="EnsemblBacteria" id="BAJ64017">
        <property type="protein sequence ID" value="BAJ64017"/>
        <property type="gene ID" value="ANT_19910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19910"/>
    <dbReference type="eggNOG" id="COG3407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_0_0_0"/>
    <dbReference type="OMA" id="LTLHAMM"/>
    <dbReference type="OrthoDB" id="645296at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="8">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="MDD_C" evidence="9">
        <location>
            <begin position="178"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6N0X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="6N0Y"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6N0Z"/>
        </source>
    </evidence>
    <sequence length="326" mass="35365" checksum="7516D51B7B885C40" modified="2011-04-05" version="1">MGQATAIAHPNIAFIKYWGNRDAVLRIPENGSISMNLAELTVKTTVIFEKHSREDTLILNGALADEPALKRVSHFLDRVREFAGISWHAHVISENNFPTGAGIASSAAAFAALALAATSAIGLHLSERDLSRLARKGSGSACRSIPGGFVEWIPGETDEDSYAVSIAPPEHWALTDCIAILSTQHKPIGSTQGHALASTSPLQPARVADTPRRLEIVRRAILERDFLSLAEMIEHDSNLMHAVMMTSTPPLFYWEPVSLVIMKSVREWRESGLPCAYTLDAGPNVHVICPSEYAEEVIFRLTSIPGVQTVLKASAGDSAKLIEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK8</accession>
    <name>E8MXK8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_20630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560459.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64089">
        <property type="protein sequence ID" value="BAJ64089"/>
        <property type="gene ID" value="ANT_20630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20630"/>
    <dbReference type="eggNOG" id="COG3745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_734964_0_0_0"/>
    <dbReference type="OMA" id="PGAQWIL"/>
    <dbReference type="OrthoDB" id="2060643at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="376" mass="40067" checksum="BC48CAC27C7D1E30" modified="2011-04-05" version="1">MATGGRRRGRAFILIALILILLLVLAWAVVRFFAPNQLPTAPGETSAPPTPVEEMTSIVISVQPISRGLEFNETNVTTIPYPKKDLVEGAFITDIQEVLGKRAKFDIEARTPITMTMLVDPTTKNSPAAFQIPPGQVAITIPVSKLSSVAYGLEPGDHVNVIVSLLLVDIDPGFQSKLPNNTGVVVAPGPSGEGGPTTISASVSKTDSLSGRTELDPTLGQPIYVIPSEPQRPRLVSQTLIQDAIVLRLGDFTSTSQQQAQTAAQQQPTPAPATGQAQQPAEAPKPDTVTLIVTPQDAVTLNYLMLAGGRLNLVMRSAGDSQRIATEPVTLQFILDQYNIPNPAKLPYGLEPRLDQFPNTIPAFPSTGSTFTATPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN3</accession>
    <name>E8MXN3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560484.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20880"/>
    <dbReference type="EnsemblBacteria" id="BAJ64114">
        <property type="protein sequence ID" value="BAJ64114"/>
        <property type="gene ID" value="ANT_20880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20880"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691959_0_0_0"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="267"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="398" mass="45657" checksum="83AF408066B39AEA" modified="2011-04-05" version="1">MSPILLIDLDDTLLENSIETFLPAYLKALSKHLSNHLQPEVMIRELLRATDQMLVNQNPQKTLEDVFDETFYPAVKVSKEELKPVIESFYRRVFPTLKSLTRPKPEAKALIEYALKKGWKIVVATNPIFPLTAIEQRLEWAGLSPKEVPFDLITSYETFHFAKPNPAYYAEVLARFGWKDEPVTMVGNSMSDDIQPAVQTGIPAFWLSDTPPESETHSPSGWGTFSEIYPFLEQIEYIRSTSILPSLNGLIGILRATLAFLDSQRRTVPLEDWNQKPSAEEWCLTEIICHLRDSDREVNLPRFRKILEEENPFLPAVNADEWSSVRQYCNNEDPLEALQGFIQARMEILSILESLSPEAWKRPARHAIFGPTTLQELVIFMCAHDRDHIQQVHKTIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN9</accession>
    <name>E8MXN9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64120">
        <property type="protein sequence ID" value="BAJ64120"/>
        <property type="gene ID" value="ANT_20940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20940"/>
    <dbReference type="HOGENOM" id="CLU_3094963_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="51" mass="5949" checksum="7D714FF5395D8171" modified="2011-04-05" version="1">MRILLLKANYNESPCISYLFYKLPEGLTKESWFIKMKISFNKKGNDGAFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ7</accession>
    <name>E8MXQ7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21120"/>
    <dbReference type="EnsemblBacteria" id="BAJ64138">
        <property type="protein sequence ID" value="BAJ64138"/>
        <property type="gene ID" value="ANT_21120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21120"/>
    <dbReference type="HOGENOM" id="CLU_3195433_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="45" mass="5337" checksum="22912FE931E31058" modified="2011-04-05" version="1">MSIQKEFFPEKTRINSLKQVLIGGKIILNIEYDLKTIPKNRRFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT4</accession>
    <name>E8MXT4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_21390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21390"/>
    <dbReference type="EnsemblBacteria" id="BAJ64165">
        <property type="protein sequence ID" value="BAJ64165"/>
        <property type="gene ID" value="ANT_21390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21390"/>
    <dbReference type="HOGENOM" id="CLU_1871102_0_0_0"/>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="14952" checksum="0E6AB2DCB0D9273C" modified="2011-04-05" version="1">MQVTIEGRDVFIFLWLLVCAVFDLRRREVPDWLTLPAVAAGLVWRVLHPDGWLAWALAGVTVALTLLGVLPGGDMKGLAALALVDPRLYLAAWLGTVGVYLLWWLVRRERSMPGYVGFLVGVVGWMIISGVLPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT7</accession>
    <name>E8MXT7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560538.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64168">
        <property type="protein sequence ID" value="BAJ64168"/>
        <property type="gene ID" value="ANT_21420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21420"/>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083537_0_0_0"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="31340" checksum="2E9B8507D97759E4" modified="2011-04-05" version="1">MEIEIVSPRKLLTGLMMIGLVVGGVWGALVHVPRARVAAAQALPSPTPTPLLTAAVFEPTATPMAVPTATPMPTPTAVPDNLQTYLEGCRKGGAAAFTPDYAGAVVAASCNHGGENRPQAVVVHATEGELPAALAHLRDPQSRVSAHYVVDRDGTVYQLVPERAVAYHVACGVEGCVSSCPAFLCGDGRPETRTVGIELVNRGKVPQDWRGAVYEDYGMAFGWRWWEEYPQAQRDALKRLVEDIAVRWGIAVDPDHVLGHYRVQGKRDPGPALNLFWERNGHPMREAVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY11</accession>
    <name>E8MY11_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative succinate dehydrogenase membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhD</name>
        <name evidence="8" type="ordered locus">ANT_22160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22160"/>
    <dbReference type="EnsemblBacteria" id="BAJ64242">
        <property type="protein sequence ID" value="BAJ64242"/>
        <property type="gene ID" value="ANT_22160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22160"/>
    <dbReference type="eggNOG" id="COG2142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145876_0_0_0"/>
    <dbReference type="OMA" id="WLFMRLS"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="127" mass="14448" checksum="35CBB4DF5F1A3E1F" modified="2011-04-05" version="1">MTTTTRPVKVKRTFEQTAWLWMRYSAFLLIPLAWGHMILQDVVVGVHSITSEYAIQRIANLGWKIYDIFLLGFAFAHGMNGVRQVVRDYIRNPKTFQIVSIVLLVVWFVITLMGAIALLAINQPIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY24</accession>
    <name>E8MY24_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560623.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22290"/>
    <dbReference type="EnsemblBacteria" id="BAJ64255">
        <property type="protein sequence ID" value="BAJ64255"/>
        <property type="gene ID" value="ANT_22290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22290"/>
    <dbReference type="HOGENOM" id="CLU_595351_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228461" evidence="2">
        <location>
            <begin position="19"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="459" mass="49938" checksum="38F3098390BF2A14" modified="2011-04-05" version="1">MKWHTLALILGASLGLCACSPTIVENSTPAVIASPPSQITSFTHPCSKPFALPREVNQLAIMPFALQEKEEQPFQLIPLGEEQAIAIANSLQPTASLCAEMNSPKIKAILETARQLHQQGKDEEARKLLRASPLSPGDTANWRQGVRDRLDLAEVMAAAGGDPQDFLTSAQQLAQGELAREVSELSTSLAGSQKTSSSTPDTSGITAVLSLAYDAGILGLDDLQTQANQLATQMGEQMLAAELEDFDPCQSDKSAVVRLLNAESQAYLLGVQGMEMDEPFYNQIRARITKAMNHQYNDLIRKRGLSPSLMLPEEPCHVRGSLEVRIFSVCSRQWSTIGRIEFEGDEDAIPMTLTGQGHISFSEHRLIEGELDCSISIDADVALTGAFRNDQGVQRIEFTPQFSSDGHYQVTSKTTGMQSSGVYPFNGFGSFIMPWVDGSVFPPSENHIIQYALSFTTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY56</accession>
    <name>E8MY56_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FemAB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560655.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64287">
        <property type="protein sequence ID" value="BAJ64287"/>
        <property type="gene ID" value="ANT_22610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22610"/>
    <dbReference type="eggNOG" id="COG2348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048411_0_1_0"/>
    <dbReference type="OMA" id="WEIFTAT"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="38175" checksum="2BAD1EAF2B0A80B1" modified="2011-04-05" version="1">MAIVNVSEWEKFLQAHPQAHILQTGAWGALKLAFGWQPVYFISGDAGAQVLFRRLPAGLSIAYVPRGPVGKDWLPLWREILPYCRKHGAVVLKVEPDAWEEEEDHLTLQMPGFIPEGIPVQPRRTLVVSLEGSEEDWLARMKQKTRYNIRLAERKGVIVQPSQDIEGFHRMMTLTGARDGFGVHSREYYQRAYDLFHPLGMAELLVALYDGKPLAGLMVFARGERAWYFYGASTDEERNRMPTYLLQWEAMRWAASRGCRWYDLWGVPDESEEVLEAQFESRHDGLWGVYRFKRGFGGVLRRSAATREYPLWKPLFPLYRWLEGRERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY63</accession>
    <name>E8MY63_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transposase for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01020</name>
        <name evidence="3" type="ordered locus">ANT_02280</name>
        <name evidence="4" type="ordered locus">ANT_03830</name>
        <name evidence="5" type="ordered locus">ANT_06680</name>
        <name evidence="6" type="ordered locus">ANT_13540</name>
        <name evidence="7" type="ordered locus">ANT_15660</name>
        <name evidence="8" type="ordered locus">ANT_16450</name>
        <name evidence="9" type="ordered locus">ANT_22680</name>
        <name evidence="10" type="ordered locus">ANT_23290</name>
        <name evidence="11" type="ordered locus">ANT_26520</name>
        <name evidence="12" type="ordered locus">ANT_29040</name>
        <name evidence="13" type="ordered locus">ANT_31520</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="9">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01020"/>
    <dbReference type="EnsemblBacteria" id="BAJ62136">
        <property type="protein sequence ID" value="BAJ62136"/>
        <property type="gene ID" value="ANT_01020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62262">
        <property type="protein sequence ID" value="BAJ62262"/>
        <property type="gene ID" value="ANT_02280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62417">
        <property type="protein sequence ID" value="BAJ62417"/>
        <property type="gene ID" value="ANT_03830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62702">
        <property type="protein sequence ID" value="BAJ62702"/>
        <property type="gene ID" value="ANT_06680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63385">
        <property type="protein sequence ID" value="BAJ63385"/>
        <property type="gene ID" value="ANT_13540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63594">
        <property type="protein sequence ID" value="BAJ63594"/>
        <property type="gene ID" value="ANT_15660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63671">
        <property type="protein sequence ID" value="BAJ63671"/>
        <property type="gene ID" value="ANT_16450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64294">
        <property type="protein sequence ID" value="BAJ64294"/>
        <property type="gene ID" value="ANT_22680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64355">
        <property type="protein sequence ID" value="BAJ64355"/>
        <property type="gene ID" value="ANT_23290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64678">
        <property type="protein sequence ID" value="BAJ64678"/>
        <property type="gene ID" value="ANT_26520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64930">
        <property type="protein sequence ID" value="BAJ64930"/>
        <property type="gene ID" value="ANT_29040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65177">
        <property type="protein sequence ID" value="BAJ65177"/>
        <property type="gene ID" value="ANT_31520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01020"/>
    <dbReference type="KEGG" id="atm:ANT_02280"/>
    <dbReference type="KEGG" id="atm:ANT_03830"/>
    <dbReference type="KEGG" id="atm:ANT_06680"/>
    <dbReference type="KEGG" id="atm:ANT_13540"/>
    <dbReference type="KEGG" id="atm:ANT_15660"/>
    <dbReference type="KEGG" id="atm:ANT_16450"/>
    <dbReference type="KEGG" id="atm:ANT_22680"/>
    <dbReference type="KEGG" id="atm:ANT_23290"/>
    <dbReference type="KEGG" id="atm:ANT_26520"/>
    <dbReference type="KEGG" id="atm:ANT_29040"/>
    <dbReference type="KEGG" id="atm:ANT_31520"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_757892_0_0_0"/>
    <dbReference type="OMA" id="HVATIAW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="175"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ65177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="39639" checksum="FB3D0EB678AE1192" modified="2011-04-05" version="1">MKIILQLPQVKRKKPARPKRCPYCQGETFQRWGVEKRRIEDVKVRHVEVVRYRCTRCRRTFRDYPEGVGNGRHSERLKKLSVILWSLGLSYRRVAGVLRIFGLRLSHMSGWRHVQAEGEKLMGELKWKSVRVVGVDGAWVGGKGVMVAVDLGDGSLLEVAEVDEKDSRALFTWLKRLKEMHDIGAIVSDDLAIYKQLTDELEIGHQVCQFHVRRWVKHALKGLQAELDPAWQGVLEKVEEILRDLPLHGDRLLHRLWKSLPGRSTPPEGKRTPLEKLRDLILRLSRDWQRYVAFYADVGIPWTNNRTEQMIGRLKSRAQQARRYKTTAGLLRGSTVACQFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY72</accession>
    <name>E8MY72_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_22770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560670.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22770"/>
    <dbReference type="EnsemblBacteria" id="BAJ64303">
        <property type="protein sequence ID" value="BAJ64303"/>
        <property type="gene ID" value="ANT_22770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22770"/>
    <dbReference type="eggNOG" id="COG3428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1208825_0_0_0"/>
    <dbReference type="OMA" id="IGRQHVF"/>
    <dbReference type="OrthoDB" id="1235841at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="3">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="211" mass="23743" checksum="13615CAD718A53D8" modified="2011-04-05" version="1">MSPAYLKRLLGENEQILLTTHQHWIVLVEQILVEIILAAVTILLVTIFLITGGGNPGIALGYLLLIIPLVSLVRDVLKWWNHQYIVTNLRVIQITGILNKNVTDSSLEKVNDVKMVQSVIGRFLDFGDLEVLTASEMGINRFTRIANPIRFKTTMLNAKIRLEDQTREATAEASIYSIPQLIEQLGELRQKGLITEEEFIEKKAALLAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY97</accession>
    <name>E8MY97_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62042">
        <property type="protein sequence ID" value="BAJ62042"/>
        <property type="gene ID" value="ANT_00080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00080"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_2_0"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="151" mass="17523" checksum="29657D7E2851299C" modified="2011-04-05" version="1">MEGEGLNGFKGFQLDFRSGVPIYEQIVAHVRQQIESGTLQPGDQLPTVRQLALELRVNFNTVARAYRLLDEAGLISTQQGRGTYILEQPPPERGERLRQRTLEEMTEDYLMGALRRGYDLEEIEQVFYRAVQRRREGQYELTDEQKGQMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE7</accession>
    <name>E8MYE7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558490.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62092">
        <property type="protein sequence ID" value="BAJ62092"/>
        <property type="gene ID" value="ANT_00580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00580"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_8_2_0"/>
    <dbReference type="OMA" id="IYEWMAG"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="255" mass="28557" checksum="4531228F9287B15D" modified="2011-04-05" version="1">MNNSLYDDLSEDYDRFVNWEQRLKVELPFLLRHLPHGRVLDAACATGWHAIALAQQGFQTAGADLSPQMIAVARRNAQAAGVTLPFEVAGFGDLARAFAASLPFDGLICLGNSLPHLLTPQDLARALADFAACLRPGGTLILQNRNFDAVLARGERWMEPQVFRKGRKTWLYLRFYDFLPEGLIRFNMVRLTRERMGWTQRVTSTFLRPLRMAEVMEMLREAGFEALETYGSMEAGGVPFDVHTSGNSIVVAHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYH9</accession>
    <name>E8MYH9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATPase</fullName>
            <ecNumber evidence="5">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_00900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558522.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00900"/>
    <dbReference type="EnsemblBacteria" id="BAJ62124">
        <property type="protein sequence ID" value="BAJ62124"/>
        <property type="gene ID" value="ANT_00900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00900"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_0"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="152365at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="52"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="463" mass="51753" checksum="0D45345D6BE408F8" modified="2011-04-05" version="1">MDLFDHAHQEQMKSEAPLAARLRPRTFDEMVGQEHIIGPGKLLRRAIETDRLFSSIILWGPPGTGKTTLAQLIAQYTQAHFEVISAVLAGVPDLRRVIQEAEERRKLYRRRTILFVDEVHRWNKAQQDALLPHVESGMITLVGATTENPYFEVISALVSRSRIFQLLPLEEHHLSILFDRALSDPERGYGKISVQVDPEARAHLIRVSGGDARNLLNALELAVESTPPDENGVRHITLDVAQESIQRRAVLYDKNGDAHYDTISAFIKSVRGSDPDAALYWLAKMLAAGEDPRFILRRLIILAGEDIGLADPHALQVAVSAAYAFDYIGMPEGIYPIAEATLYLATAPKSNSVGEAYYSALERIQQEGAGPVPVHLMDASRDARGLGHGKGYLYPHDFPDHFVPQQYLPASLQGTIFYNPSDQGYEAQILERLKRWRAWKTAQTEPASHENTDHPAVDSPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI7</accession>
    <name>E8MYI7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_22970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560690.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22970"/>
    <dbReference type="EnsemblBacteria" id="BAJ64323">
        <property type="protein sequence ID" value="BAJ64323"/>
        <property type="gene ID" value="ANT_22970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22970"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017999_1_1_0"/>
    <dbReference type="OMA" id="VGHWYEH"/>
    <dbReference type="OrthoDB" id="100199at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="647" mass="71185" checksum="8CFF475385A50B2B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ1</accession>
    <name>E8MYJ1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_23010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560694.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23010"/>
    <dbReference type="MEROPS" id="M23.A03"/>
    <dbReference type="EnsemblBacteria" id="BAJ64327">
        <property type="protein sequence ID" value="BAJ64327"/>
        <property type="gene ID" value="ANT_23010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23010"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952011_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225157" description="Peptidase_M23 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="203"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="292" mass="31205" checksum="91D493FBE59F1D35" modified="2011-04-05" version="1">MHRQFVVLAGWMLVFLLAGCTSSPTPGLGSTVTNAPMASLPSSVEVSTPSESSPSPTSIQRTEETLAPAGSEEVSALCSPLEGIALENLNTPDLLKTPFQAPPPGDDGGHFGVDFAYWTSPEGKPMLGLPVNAILDGKVAGIIYNRKPYGNTIILETPLENLPEEIRERLPELNAQTVPTPIPPCSLSCPSIPFQGNFSSLSLYHLYAHLNKPPSLTLGESVNCGTEIGEVGSTGNSVNAHLHLETRLGPSGVVFPSMAHYDNSASPEEMGWYCLWRISGFFQAFDPMILFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK1</accession>
    <name>E8MYK1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560704.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23110"/>
    <dbReference type="EnsemblBacteria" id="BAJ64337">
        <property type="protein sequence ID" value="BAJ64337"/>
        <property type="gene ID" value="ANT_23110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23110"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053514_1_1_0"/>
    <dbReference type="OMA" id="LWFTRWQ"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="78"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="264" mass="29418" checksum="8B6CD41E27EA88A9" modified="2011-04-05" version="1">MFVFLSKLLAPFLYPLGMALVLLALSLFKWKNIRWRNLFTGLALFILLVSSNRWVATTLARSLEWQYLPNEPISSAPAMVVLGGGTEPAFPPRSQPEVNSAGDRVLYAAALYQQGKAPLVIVSGGNVAFRGEQSSTPASDMRHLLKMLGVPPEAILEEDQSQNTYENALYCAKLLKERHIQRVILVTSALHMPRSVKLFEKQGIEVIPAPADFAVPFQEWEDLLHAPIPAQLVALLPSSSNLQLTTNVLHEYIGILVYWMRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM3</accession>
    <name>E8MYM3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein FtsI</fullName>
            <ecNumber evidence="5">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsI</name>
        <name evidence="5" type="ordered locus">ANT_23330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.129" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560725.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23330"/>
    <dbReference type="EnsemblBacteria" id="BAJ64359">
        <property type="protein sequence ID" value="BAJ64359"/>
        <property type="gene ID" value="ANT_23330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23330"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_2_0"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="55"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="267"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="601" mass="67238" checksum="3B2D6D56E567BAF4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ04</accession>
    <name>E8MZ04_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_01130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558545.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62147">
        <property type="protein sequence ID" value="BAJ62147"/>
        <property type="gene ID" value="ANT_01130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01130"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791418_0_0_0"/>
    <dbReference type="OMA" id="DINLTIC"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="350" mass="37777" checksum="CFF4B376779CA141" modified="2011-04-05" version="1">MNAPAAPYISLQDVVKTFPAPGGEVMVLKHIYLDIQPGEYVSIVGKSGSGKSTLLNMITGIDHPTSGTVTVAGTQPHRLSESQLAGWRGVTIGIVFQFFQLLPMLSLLENVMLPMDFCNRYPPAEREGRARALLEQVGLGDMVDKLPGAVSGGQQQAAAIARALANDPPLIVADEPTGNLDERTAEGVLALFDGLVARGKTVVIVTHDPALVKRTQRTILLSDGEIVNPFIAQALPHLSHPQLLQLTHLARPQTLSRGESLTLPPYAPGLLVLTQGKLALWKPARRGEILWRELRPAQALTAQDVAFHTPLRLQALEDSAWLEIPAEAWETWLAQSGARASLAPVTEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ31</accession>
    <name>E8MZ31_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558572.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01400"/>
    <dbReference type="EnsemblBacteria" id="BAJ62174">
        <property type="protein sequence ID" value="BAJ62174"/>
        <property type="gene ID" value="ANT_01400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01400"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="DVLTMKW"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="37582" checksum="EF079E623D622BF3" modified="2011-04-05" version="1">MNESTQNKPLLEVKNLKTYFFTEDGVVKAVDGVDFHVNQGEVLGLVGESGCGKSVTSLSIMRLLGVPGKVVDGEIYFAGQDLLKLPESEMVKMRGNRMSMIFQQPQSSLNPVFTVGDQVAEVLMIHQNLGKEAAWNRAVELLAMVGIPDPARKAKAFPHEMSGGQAQRVMIAMALALAPELLIADEPTTALDVTIQAQILDLIQEMREKLGTSVILITHDLGIIAEMAHRVAVMYAGRIVEEASVKELFENPMHPYTKGLIASIPILGKVTDRLEVIPGSVPNLINLPPGCRFAPRCRLREQYGLEICTRDEPELVEVKPGHKVRCWLYADKDDHRAPLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ82</accession>
    <name>E8MZ82_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aroC</name>
        <name evidence="10" type="ordered locus">ANT_01910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01910"/>
    <dbReference type="EnsemblBacteria" id="BAJ62225">
        <property type="protein sequence ID" value="BAJ62225"/>
        <property type="gene ID" value="ANT_01910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01910"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_0"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="397" mass="42559" checksum="34A20800BB1575A6" modified="2011-04-05" version="1">MEEGETMTLRFLTAGESHGPALSVILDGIPAGLPLNEDILARDLTRRQQGLGAGARMKLEHDRARILGGVMAGVTTGAPLALLIENADHARWKGKDIPPFTTPRPGHADLSGALKYGYRDLRPALERASARETAARVAVGAVCRHLLGQFGIQVGGYVVSIGGVESRLEGMPYAERIARALESDVSCPDAQAAEDMRAAIRTVMQARDTLGGVIEVAALNVPPGLGSYAQWDRRLEARIGAALLSVPAIKGVEFGPAFANTRLPGTQVHDPIRLEGERIIRTGNRSGGLEGGITNGEPLVVRAAMKPIATTLTPQPTVDLAQGVETETRYERSDFCPVPRAVVILEAMLAFVLTDALLEKLGGDSLAEILPRFERLRQARLSDLPMDGTPHRFWEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZL7</accession>
    <name>E8MZL7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25390"/>
    <dbReference type="EnsemblBacteria" id="BAJ64565">
        <property type="protein sequence ID" value="BAJ64565"/>
        <property type="gene ID" value="ANT_25390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25390"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_8_0"/>
    <dbReference type="OMA" id="GEYRRVW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="186" mass="21600" checksum="340BFB90C12B55E4" modified="2011-04-05" version="1">MRQRILREATRQFVERGFDGVSIRDLAEACQVTNAALYYHFPDKEHLFLEILEQGLENFTRILRNAREKYPASTQDCLKEFILGIFTQVPPESRGVMRLATQEMEKLSPGLREKFKEIYAKEFLHPLEEILREGQARGEVRPLPSNLLVWAFLGIFYPFLASESHPNFSADTPEILLSIFWKGIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ2</accession>
    <name>E8MZQ2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64600">
        <property type="protein sequence ID" value="BAJ64600"/>
        <property type="gene ID" value="ANT_25740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25740"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371992_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="747" mass="83322" checksum="C64F27B1DD786B36" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR2</accession>
    <name>E8MZR2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64610">
        <property type="protein sequence ID" value="BAJ64610"/>
        <property type="gene ID" value="ANT_25840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25840"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_0"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="312" mass="35055" checksum="77B8AF9CE701CEE9" modified="2011-04-05" version="1">MKGMEYKDYYQILGVNRNASDDEIKRAFRKLALKYHPDRNPGNKQAEEKFKEINEAYEVLSDPEKRRRYDQLGDSYFRWQQSGAPGGFDWSQWVSQPAGGVRVEVGDLDDLFGGSFSEFFQSIFGGYARSAGTATAGTRTRTRTARPAPVEYPIQITFEEAYRGGERTLDIDGRRVQVKIPAGADNGTKIRMAGMGQVMPDGTRGDLYLVVEITPDPRFERKGHDIYTEFDLDLYTAVLGGEARLQTPEGAVLLTIPAGTQPGQTFRLAGRGMPYLKNPSQRGDLYARAKVSLPRHLTPEQRALFEQLARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS9</accession>
    <name>E8MZS9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560982.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26010"/>
    <dbReference type="EnsemblBacteria" id="BAJ64627">
        <property type="protein sequence ID" value="BAJ64627"/>
        <property type="gene ID" value="ANT_26010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26010"/>
    <dbReference type="HOGENOM" id="CLU_873313_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="318" mass="34748" checksum="5CD19C8A4A0BAC9F" modified="2011-04-05" version="1">MNIIHMETDLVYEQGKKMMYTASDFFNLVDHLQNAIEDLRQAWSSPRATTYLLEIEKIHKDLVNQVHVLDELSRRVRQEVDEWIETDRTQSAYLTALRESFEITSSDLDKVVAGAVLSSTLQWSVKRPNSIIFTGNNWMRKALGIKEMVRVIKPSTLARGMAIGGTIEALGSGISTSVESFLENGQQDISRGISAAVIDFNVKTILTGIGSVGIPVLLGGMVSVTGLPVIAGGAVIIGGSVLLGLAYSKFVEAPLWEMWKGSTLHEEAIESGKRAIDKISNAVSHLTSQFVQKTEKAFSNVIRGILDTTPVVCIPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N015</accession>
    <name>E8N015_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative M3 family peptidase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_03160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558747.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03160"/>
    <dbReference type="EnsemblBacteria" id="BAJ62350">
        <property type="protein sequence ID" value="BAJ62350"/>
        <property type="gene ID" value="ANT_03160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03160"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030403_3_0_0"/>
    <dbReference type="OMA" id="CAFQFWK"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011976">
        <property type="entry name" value="Pept_M3B_oligopep-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02289">
        <property type="entry name" value="M3_not_pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="164"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="563" mass="65067" checksum="EF981CABA8C0FC73" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N072</accession>
    <name>E8N072_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_03730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558804.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03730"/>
    <dbReference type="EnsemblBacteria" id="BAJ62407">
        <property type="protein sequence ID" value="BAJ62407"/>
        <property type="gene ID" value="ANT_03730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03730"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_3_0"/>
    <dbReference type="OMA" id="LRWHPGY"/>
    <dbReference type="OrthoDB" id="1694312at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="52"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="27673" checksum="0AE5CA0A3B8045C4" modified="2011-04-05" version="1">MKRRDYLLALLALLALWQILAWLVNQPILPDPWRVLRALVQETLSGDLPKHFLASLWRVVASTLLSILLAAPAGLVLGQSRRLNRLFTPMIYLLYPIPKVVFVPVLLLFFGIGDLSKILVIFLILFFQILVLVRDQAAALRPELILSVRSLGAGRRALFRFVYLPASLPGILTALRQSIGTAVAVLYVAELFATRVGLGYYIYFQGSTLLNYPAMYAGILAMSFLGLGLYFLVDGLERRLCRWQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E3</accession>
    <name>E8N0E3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ordered locus">ANT_26660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561044.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64692">
        <property type="protein sequence ID" value="BAJ64692"/>
        <property type="gene ID" value="ANT_26660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26660"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_1_0_0"/>
    <dbReference type="OMA" id="RSINMTI"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="97" mass="10395" checksum="481E382C4D575A09" modified="2011-04-05" version="1">MAINLKPLGSRVVVEPIESEDVTPGGIVLPETAKEKPQKGKVLSVGPGDRDDKGNRISMDVKVGDVVLFAKYAGTEIKVDGKKLLILRESDLLAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H9</accession>
    <name>E8N0H9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">add</name>
        <name evidence="4" type="ordered locus">ANT_27020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561080.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27020"/>
    <dbReference type="EnsemblBacteria" id="BAJ64728">
        <property type="protein sequence ID" value="BAJ64728"/>
        <property type="gene ID" value="ANT_27020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27020"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_0_2_0"/>
    <dbReference type="OMA" id="DERLMQR"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="333" mass="36725" checksum="CA6271FD4402F7A9" modified="2011-04-05" version="1">MVDDTLPLIDLHRHLDGSVRLETILDLGRQHNLNLPAWDVESLRPFVQVSEAQPGIMAFIARFEWMTGVMVNADAVRRIAFENVEDLHREGVDYAELRFSPLFMAQPHHLDPVEVIDAVVDGVRAGSQKTGVQVNLIGILSRTYGVDACWQELRAILARREAFVAVDLAGDEAHFPGEWFVEHFKAVRDAGLHVTVHAGEAAGAESVWQALRELGAERIGHAVHAPEDPALMDYLATHGIGVEVNLTSNVQTTTVPSYKDHPVRLFLEHGIRAVLNTDDPGISGIDLPYEYNVAAPAAGLTPAQIRQLQSNALEAAFLSPDEKQALRERRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0K8</accession>
    <name>E8N0K8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561109.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64757">
        <property type="protein sequence ID" value="BAJ64757"/>
        <property type="gene ID" value="ANT_27310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27310"/>
    <dbReference type="eggNOG" id="COG1431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372063_0_0_0"/>
    <dbReference type="OrthoDB" id="196845at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="386"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="617" mass="69611" checksum="CA1392DF676CC739" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N9</accession>
    <name>E8N0N9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558830.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04000"/>
    <dbReference type="EnsemblBacteria" id="BAJ62434">
        <property type="protein sequence ID" value="BAJ62434"/>
        <property type="gene ID" value="ANT_04000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04000"/>
    <dbReference type="eggNOG" id="COG3868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051214_3_1_0"/>
    <dbReference type="OMA" id="STGAWED"/>
    <dbReference type="OrthoDB" id="1327691at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225195" description="Glyco_hydro_114 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_114" evidence="2">
        <location>
            <begin position="58"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="32605" checksum="25C6F73286DCCAA9" modified="2011-04-05" version="1">MRLRFAHLVLILSIALAGCAPALPPAPSFVRFTETAEMSSENSPHPAADWWRPTVGLTWQWQIGNNEIDTRVDVDVYDIDLYVDQAVIDELHAQGRRVICYISVGSWEDWRPDKDRFPAEVLGKDYEGWQGEKWLDIRQIDKLAPIMLARLDLCQAKGFDAVEPDNMEIYTNDTGFPLTYKDQLKYALWLAEEAHKRGLAIGQKNAADMVADLVNVFDFAITEDYFYYGEAESMLPYIQAGKPVFAAEYTDLPGDFEEFCRQSRKLGFSTILKNRELDAWVKFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q3</accession>
    <name>E8N0Q3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent Clp protease ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_04140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04140"/>
    <dbReference type="EnsemblBacteria" id="BAJ62448">
        <property type="protein sequence ID" value="BAJ62448"/>
        <property type="gene ID" value="ANT_04140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04140"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_0"/>
    <dbReference type="OMA" id="GPEHILM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="818" mass="92364" checksum="FF199AB6355E2268" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R7</accession>
    <name>E8N0R7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04280"/>
    <dbReference type="EnsemblBacteria" id="BAJ62462">
        <property type="protein sequence ID" value="BAJ62462"/>
        <property type="gene ID" value="ANT_04280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04280"/>
    <dbReference type="HOGENOM" id="CLU_2875865_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="63" mass="7250" checksum="3B2CD3DCC8099486" modified="2011-04-05" version="1">MIDQNNNQLKTFSKVTFFTFWLDNHHNHNQFSPELSSRNSLQTVNNLAGGMGKITGKETLYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y1</accession>
    <name>E8N0Y1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">thrC</name>
        <name evidence="14" type="ordered locus">ANT_04920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558922.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04920"/>
    <dbReference type="EnsemblBacteria" id="BAJ62526">
        <property type="protein sequence ID" value="BAJ62526"/>
        <property type="gene ID" value="ANT_04920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04920"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_0"/>
    <dbReference type="OMA" id="MWGFQAS"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="33"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ62526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="366" mass="38657" checksum="F9C48180D0536BA9" modified="2011-04-05" version="1">MRGFLNTPDSSLYSGVLARYGAWMDLPAHTRPVTLLEGNTPLIPMPRLAQELGGGFELFVKFEGMNPTGSFKDRGMTAAISEAFGRGVHTVICASTGNTAASAAAYAARAQMRAIVIIPEGKVAAGKLAGAVAYGAQVIQIQGSFDDALSLVVEISERHPIALVNSLNPYRLEGQKTAAFEIVDALGSAPDWLCLPVGNAGNITSYWMGFRQDHARRSSGLPRILGVQAEGAAPLVLGHPVEHPETVATAIRIGKPARGEQALEAAEQSGGRIIAVSDAEILAMQRRLAGEGVWVEPASAAGLAGLARQLREGKMRLSELRGRRVVAVCTGHGLKDPEIIAHNMPAPLRLPARMDALEEAILGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N130</accession>
    <name>E8N130_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27470"/>
    <dbReference type="EnsemblBacteria" id="BAJ64773">
        <property type="protein sequence ID" value="BAJ64773"/>
        <property type="gene ID" value="ANT_27470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27470"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2140652_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="112" mass="12303" checksum="21B7ED5F00970BBE" modified="2011-04-05" version="1">MFEAYYGKLPPVLKSVSLFLDDGSVFTGDLPLEPYAFDNPTALATWKMLRERGARRMDRFGILTGCHQGVCQSHKWGGVLGQASEESGISKPPHQRLTTPPDMGKCFALATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N153</accession>
    <name>E8N153_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0173 metal-dependent hydrolase ANT_27700</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0173 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561144.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64796">
        <property type="protein sequence ID" value="BAJ64796"/>
        <property type="gene ID" value="ANT_27700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27700"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_4_1_0"/>
    <dbReference type="OMA" id="WHGHSTW"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00457">
        <property type="entry name" value="UPF0173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022877">
        <property type="entry name" value="UPF0173"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="227" mass="24487" checksum="7006DC8FA43027E6" modified="2011-04-05" version="1">MGLTFTWYGHATIGLETGGYHLLVDPFFSGNPAATAKPNEVRADFILVSHGHGDHVGDTEMIAKRTGALVISNFEISSWLGRKGLKTHGQHLGGGYRYPFGYLKLTFAIHGSALPDGSYGGNPAGFLLTTNAGEKVYLAQDTGLFGDMKLIGDEGIDLAALPIGDNFTMGPDDALRAVELLRPKHVIPIHYNTFELIQQDAHAWAKRVEEATSAKVHVLKPGESFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N158</accession>
    <name>E8N158_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB</name>
        <name evidence="6" type="ordered locus">ANT_27750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561149.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27750"/>
    <dbReference type="EnsemblBacteria" id="BAJ64801">
        <property type="protein sequence ID" value="BAJ64801"/>
        <property type="gene ID" value="ANT_27750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27750"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="261" mass="29527" checksum="8672491698AC6625" modified="2011-04-05" version="1">MSEQNHSNHYAIETRNLNLYYGNFRAVKEVNLQIVPRKITAIIGPSGCGKSTVLRSFNRMNDFVPGFRMEGEILFHGKNLYAPDVDPVQVRQYIGMVFQKPNPFPKSIYENVAWGARINGYKGNMDELVEEALRGAALWDEVKDNLKKSGLSLSGGQQQRLCIARALAVKPEIILMDEPCSALDPIATLKIEDLMRELSQNYTIIIVTHNMQQAARASDYTAFFTMDEDRAGVMVEYGETSQIFTTPRDKRTEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E0</accession>
    <name>E8N1E0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosidase</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64883">
        <property type="protein sequence ID" value="BAJ64883"/>
        <property type="gene ID" value="ANT_28570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28570"/>
    <dbReference type="eggNOG" id="COG3405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037722_0_0_0"/>
    <dbReference type="OMA" id="FDRLWKW"/>
    <dbReference type="OrthoDB" id="636673at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00735">
        <property type="entry name" value="GLHYDRLASE8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225213" evidence="3">
        <location>
            <begin position="29"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="442" mass="50420" checksum="5989002BC672BEF9" modified="2011-04-05" version="1">MRNFMFRNTLFRISMVLVLFLSACSVPQTPPVPPTETPEPSATPIPTQPPTATSVPVPSPRSFFTGEYRNLFKEYLGKSDAEVQEKLEAAFQHFFYGDDTTQRVYYPVGEDMAYIMDIGNNDVRTEGMSYGMMIAVQLDKKEEFDRLWKWTKTYMYQSEGPYRGYFAWHCTPEGKQLAANPASDGEEWFVMALLFAAGRWGNGEGIFNYQAQAQEILDTMLHKNEEDTGLATNMFDPQTYQVVFVPSGRSATFTDPSYHLPAYYELWARWAERDRDFWEKAVQASREFFPKAAHPETGLMPDYSHFDGTPVDDPEHSDFRFDAWRTLSNVAVDYAWFGADPWQVEQSTRVLKFLTREGVNAFANQYTLDGKPLSGDHSAGLVAMAAVAALATDRETGEPFVQALWDLRFPSGKWRYYDGMLTMLALLHVSGQFRIYPPGNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F9</accession>
    <name>E8N1F9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/hydrogen exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_28760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64902">
        <property type="protein sequence ID" value="BAJ64902"/>
        <property type="gene ID" value="ANT_28760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28760"/>
    <dbReference type="eggNOG" id="COG3263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_9_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="11"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="306" mass="32600" checksum="1EFE21B1F322E87D" modified="2011-04-05" version="1">MNDYVLIAAALLLLFSVLISKISDRFGVPTLLLFLILGMLAGSDGPGGIYFDNPAQAQFIGVIALVLILFSGGLDTEWRHIQPVLKEGLLLSTLGVLITAGVAGLCAHLLLDLSLTEGLLFGAIVSSTDAAAVFSVLRSRGIHLQGKLKPLLELESGSNDPMAVFLTLGLIQWLTQPNPSVGQMVGLFIQQMLIGAVLGLGMGRVMLFLINRLKLGYEGLYPVLTLSLVFLTYGVTAVLGGSGFLAVYMAGIVLGHYDFIHKRSLLRFHDGLAWLMQIAMFLTLGLLVFPSRLLPIVGGGCSAPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K9</accession>
    <name>E8N1K9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methylmalonyl-CoA decarboxylase alpha-subunit</fullName>
            <ecNumber evidence="4">4.1.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mmdA</name>
        <name evidence="4" type="ordered locus">ANT_05800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.41" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559009.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05800"/>
    <dbReference type="EnsemblBacteria" id="BAJ62614">
        <property type="protein sequence ID" value="BAJ62614"/>
        <property type="gene ID" value="ANT_05800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05800"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_0"/>
    <dbReference type="OMA" id="YAYAECT"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="281"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="534" mass="58008" checksum="FA8FA17504B800A2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q8</accession>
    <name>E8N1Q8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fcl</name>
        <name evidence="4" type="ordered locus">ANT_06290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559058.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06290"/>
    <dbReference type="EnsemblBacteria" id="BAJ62663">
        <property type="protein sequence ID" value="BAJ62663"/>
        <property type="gene ID" value="ANT_06290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06290"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_18_0_0"/>
    <dbReference type="OMA" id="IHCAGRV"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="171"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="320" mass="36328" checksum="6439628CAB49BFAF" modified="2011-04-05" version="1">MQVESFWHGKRVCVTGGAGFLGQFVQKKLRERGVSQEQIFVPHYPEYDLVKPEDVRRVLDDSRPDVIIHLAAHVGGIGANREHPAEFFYDNLMMGVQLMHEAWKKGVGKFVAIGTVCAYPKFTPVPFKEDDLWNGYPEETNAPYGLAKKMLLVMAQAYRQQYGFNAIFLLPVNLYGPGDNFDLQSSHVIPAMIRKFIEAEEAGKDEVVLWGDGSPTREFLYVEDAAEGIVRATEAYEGSDPVNLGSGYEIRIRDLAELIARLTGYSGKIVWDTTKPNGQPRRALDTTRAEKYFGFRARTNFEEGLQKTIEWYRQNRHKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1U9</accession>
    <name>E8N1U9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559098.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06700"/>
    <dbReference type="EnsemblBacteria" id="BAJ62704">
        <property type="protein sequence ID" value="BAJ62704"/>
        <property type="gene ID" value="ANT_06700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06700"/>
    <dbReference type="eggNOG" id="COG4143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_6_1_0"/>
    <dbReference type="OMA" id="PTTNWMY"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13545">
        <property type="entry name" value="PBP2_TbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225220" evidence="1">
        <location>
            <begin position="30"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="363" mass="39948" checksum="234A0ECFDB5CFBF8" modified="2011-04-05" version="1">MIRKLWMWLMVLMMALGACVPQTTTPAPAQATTPAVSASQPVELRVMTHDSFAVSEEIVRAFEAEHRAKVTFIKSGDTGAALNRAILTRENPQADVFYGVDNTFLSRALDENIFEPYASPLLEKIPASFKLDSSNRALPVDYGDVCINYDKAYFAEKNLPIPQSLEDLTKPEYRGLLVVENPATSSPGLAFLFATIAHFGEEGYLDYWKALRANDVVVASDWESAYYTYFSASSGKGPQPMVVSYASSPAAEVIFAEQPLSDAPTASLTGAGMCYRQIEFVGILKGTPQRKLAEAFVDFMLGKTFQEDMPLQMFVFPVNSEATLPEAFTRYAQVAEQPAALDSAVIAAKREAWIQAWTEAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z1</accession>
    <name>E8N1Z1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561282.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29120"/>
    <dbReference type="EnsemblBacteria" id="BAJ64938">
        <property type="protein sequence ID" value="BAJ64938"/>
        <property type="gene ID" value="ANT_29120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29120"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033147_0_1_0"/>
    <dbReference type="OMA" id="NFWCRYL"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="303" mass="33913" checksum="B7B37B09F87A6D68" modified="2011-04-05" version="1">MQAKVKTSLFNKRFFRKNIWIRRVVQFFFFALIALIAVNHTLAETGQSIPFLSSASLHALCPFGGVETLYAYLTTGSFVQKIHESSFILMIISLLTALLFGPVFCGWVCPLGTVQEWFASIGRKLFKRRRYNHFIPAKIDRWLRFLRYGVLIWVLYMTATTGKLIFADVDPYFALFNFWSSEVAVGGLIVLGAILLASLFVERPWCKYACPYGAVLGLTNLVRIFSIRRTASTCRMDGACDITCPMNINVSAKSVVRDHQCISCLECTSEAHCPVAGTVTFSTARIPGKSISFAKPQIIAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N204</accession>
    <name>E8N204_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561295.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29250"/>
    <dbReference type="EnsemblBacteria" id="BAJ64951">
        <property type="protein sequence ID" value="BAJ64951"/>
        <property type="gene ID" value="ANT_29250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29250"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_8_1_0"/>
    <dbReference type="OMA" id="SYYREGI"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13477">
        <property type="entry name" value="Glyco_trans_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="373" mass="42474" checksum="0AF220D3431BA2DD" modified="2011-04-05" version="1">MKILLVANTDWFLYNYRLNFARFLREQGHEVVLVSPAGEYAPALQTAGFRWVRWEVGRQSLAPWKELDAFWRLAQIYRRERPDVVNHLTIKPVLYGGLAAQWTGVPRVVSNITGRGYALVSEERKARLLRPLVLALYRLILRSKRQQVLFENDLDRQYFIEQKLLRPEQAHLLAGLGVNVERFHPVQHQNEVPMVLFAGRFLREKGLEDLVEAGKILRQRGVRFRLALAGDVDAGNPLSLERETVQAWADSGWVEWWGFQPRMEEVYAQADVFVFPSFYGEGLPSALMEAAACGLPIVASDLPGCRAVVEDGVNGFIVPARDVEALANRLEDLLRSEDVRRQMGTASRQIALQRFNQNAVNRQILAVMEGKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N234</accession>
    <name>E8N234_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_29550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64981">
        <property type="protein sequence ID" value="BAJ64981"/>
        <property type="gene ID" value="ANT_29550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29550"/>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034545_0_3_0"/>
    <dbReference type="OMA" id="EDHTWVA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="383" mass="41753" checksum="B803DE021E9B9BA6" modified="2011-04-05" version="1">MRRMERPVVPVAAISHTGMRRRGNEDRYGVFAYRQYPPFSLPVVLLVLCDGVGGHRAGEVAAEIAVEQIDAAVAASDGLNPPQILYQAIQQASEAIRKQAEENPDQIGMGATCACAWIAGRRLYTATVGDTRIYLIRQGKAHRLSIDHTWVQEAMEQGILKPEEVEGHPNQHVIRRYLGSPIPPEVDLRLCWDELPPQNDEQRLANQGLMLQEGDLIVLTSDGLTDLVSDGEIAATFEALPVKEALSRLVEMANIRGGFDNITIVAARIPQAQYREEATRPLKSVPGARRRSVWRWVGWLGILLLLVGMSVIAGWWLSGGTRIQPATPTVSAAVSPTLVQVSPNPLPSATPAPPTPTAETRPSPTEQSGNAPTLTPWPTQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N288</accession>
    <name>E8N288_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561376.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30090"/>
    <dbReference type="EnsemblBacteria" id="BAJ65035">
        <property type="protein sequence ID" value="BAJ65035"/>
        <property type="gene ID" value="ANT_30090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30090"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_1_0_0"/>
    <dbReference type="OMA" id="NDQMLHP"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="42"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="36260" checksum="28810A65B5130CC4" modified="2011-04-05" version="1">MSERSFSIRFWGVRGSYPVPGASTVRYGGNTPCVEVQVNGYTIILDAGTGIIPLGRELMRRARASGKTVEAVLLFSHLHHDHTQGFPFFAPAFVPSTRLHVFGPDFLASSPKVTLDTVMNPPYFPIRLAELNAWLGFATLRETDVILVGESVGGVALFSAGDTIPAADPNLVLIRILRSYAHPQGVLHYRIDWRNHAMVYATDTEGYVNGDRRLANFAHGVDLLIHDAQYTDEHYLGLVPGLPNTQGFGHSTISIAVQAAQASEAKRLVLFHHAPEYSDDQLDFIQEQVERIQPGTLVAQEGMTLTLYDEAEPLPPQERPVPVNLQRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B2</accession>
    <name>E8N2B2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561400.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30330"/>
    <dbReference type="EnsemblBacteria" id="BAJ65059">
        <property type="protein sequence ID" value="BAJ65059"/>
        <property type="gene ID" value="ANT_30330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30330"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359704_0_0_0"/>
    <dbReference type="OrthoDB" id="26006at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="778" mass="87525" checksum="9337AD1E11338B9F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C0</accession>
    <name>E8N2C0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">folA</name>
        <name evidence="2" type="ordered locus">ANT_06920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559120.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06920"/>
    <dbReference type="EnsemblBacteria" id="BAJ62726">
        <property type="protein sequence ID" value="BAJ62726"/>
        <property type="gene ID" value="ANT_06920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06920"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_2_0"/>
    <dbReference type="OMA" id="GYIAKPN"/>
    <dbReference type="OrthoDB" id="1306955at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="187" mass="20789" checksum="D0A3ECEA4EA2D264" modified="2011-04-05" version="1">MSLETTSLVPIRCSVFMALSLDGFIARPDGGLDWLPQPEPGEDYGYTRFIETVDTVLMGRNTFDQVLTFPEYPYADQSVVVLTTRPLALPAHLAGKVQWMQGEPAQILARLAEQGARHVYVDGGETIRRFLRAGLIQDIILTHVPVLLGRGIPLFGDLDGEIPLEHVETVVYTRGLVQSRYRVLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C8</accession>
    <name>E8N2C8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serA</name>
        <name evidence="6" type="ordered locus">ANT_07000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559128.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07000"/>
    <dbReference type="EnsemblBacteria" id="BAJ62734">
        <property type="protein sequence ID" value="BAJ62734"/>
        <property type="gene ID" value="ANT_07000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07000"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_0"/>
    <dbReference type="OMA" id="VHHQTLG"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="6"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="33930" checksum="4504BCA204378D4A" modified="2011-04-05" version="1">MATYKIMITDGLAEKGKAYLREYGEVIDRTGISPEDLLKEVGEVDALIVRSRTKVNAAVFEAGKRLKVVGRAGIGVDNIDLNAARAAGVTVVNSPLATTVSVAELAMGLMLALVREIPRADASMKQNKWLKKEFEGHELYQKTLGIIGCGRIGSAVAERAQAFGMHVLAFDRFRPKDELCQCSEPVDDLNDLLARSDFLSLHLPLTAETKNLLSHEQFARMKDGVYLINASRGGIVDEEALLAALNSGKVAGAALDVFAVEPPSENNPLVMHPRVICTPHMGAQTHEAQARAGYDIATEVVAALKGEPLRWKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F6</accession>
    <name>E8N2F6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559155.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07280"/>
    <dbReference type="EnsemblBacteria" id="BAJ62762">
        <property type="protein sequence ID" value="BAJ62762"/>
        <property type="gene ID" value="ANT_07280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07280"/>
    <dbReference type="eggNOG" id="ENOG502ZDSU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2299835_0_0_0"/>
    <dbReference type="OrthoDB" id="2218692at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="100" mass="10808" checksum="1614DC4C0A9D4E24" modified="2011-04-05" version="1">MAKKFLTAKDIDFHADQGVKEIHIGDDVVITDLGQERARERGVTLTRLPAGVKSPPHPSCEAMPSDAEIFAQVRSAVIARFGGTPDGLDQIIQKVLTGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J3</accession>
    <name>E8N2J3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_07650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559192.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07650"/>
    <dbReference type="EnsemblBacteria" id="BAJ62799">
        <property type="protein sequence ID" value="BAJ62799"/>
        <property type="gene ID" value="ANT_07650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07650"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="OMA" id="MGSNMIT"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="309"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="408" mass="43389" checksum="9B3D2A1878BADB70" modified="2011-04-05" version="1">MIVLQSIIEALQSLTANKLRSALTILGIVIGVAAVIAMLAVGNGAQAAITGSISGIGTNLLFVFTGNLEGNIRNAKPLTLGDVDAIKDAFQAPHVANAAPAIQADREVSFGGERTRPTLIGITPEYLEVRNFKLSEGEPINETHILERASVALIGTEVADKLFGTREGITGQVIRIEGQPFRILGVLESKGGGAFGSQDNVVMVPFSTAQERLIRRSRERVDIIFVQAVDANSVPLAAEEVAQILRQRHRTEVGADDFTIFTQQDFISTARQITSVLTIFLGGIAAISLLVGGIGIMNIMLVSVTERTREIGLRKALGARKRDILIQFLTESSLLSLIGGLIGIALGWLIAFVVGQIAAANNTELTPVVGIDAILLATLFSTAVGLFFGIYPASRAANLEPVEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J4</accession>
    <name>E8N2J4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559193.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07660"/>
    <dbReference type="EnsemblBacteria" id="BAJ62800">
        <property type="protein sequence ID" value="BAJ62800"/>
        <property type="gene ID" value="ANT_07660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07660"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="RMKDFDA"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="229" mass="24901" checksum="C9D11D5D01B2D40E" modified="2011-04-05" version="1">MSSEYVIEAFDLTKIYRMGSVEVRALAGVSLKIRRGEMVAIMGPSGSGKSTLMNVLGCLDRPTSGRYLLDGEETSKLSDDQLASIRNRKVGFVFQSFNLLPRVTALGNVELPLRYAGVTKGRSERAKEALIAVGLAERLYHRPSELSGGQQQRVAIARALVNNPAILMADEPTGNLDSKSGKEIMELLIHLNRDRGATVIIVTHDPNVAAQTQRVIRLMDGLIVEDGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N2</accession>
    <name>E8N2N2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_08040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559230.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08040"/>
    <dbReference type="EnsemblBacteria" id="BAJ62838">
        <property type="protein sequence ID" value="BAJ62838"/>
        <property type="gene ID" value="ANT_08040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08040"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065155_2_2_0"/>
    <dbReference type="OMA" id="FIHFYFD"/>
    <dbReference type="OrthoDB" id="1962890at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="234" mass="26654" checksum="D3A8FAD6AA727E2F" modified="2011-04-05" version="1">MATITISRQFGSGGDEIARMVADMLNYRMFDKWMILNAARESGLSEQEIIDYSEDNYRVRGFLERLFARTAPISITYGVIEEPYSVHLLEQELSEETALRLVQKAVQSAHAQGNVVIVGRGGQVILQNEPNTLHVRIEAPLEDRILRVKQQIREQNHRGYADIQPRRQAQNLIEERDAASADYIKRFYEANWADPMLYHMVLNTGKLSLEQAANLIVQAVKELESRSQQAAQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S1</accession>
    <name>E8N2S1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561412.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30450"/>
    <dbReference type="EnsemblBacteria" id="BAJ65071">
        <property type="protein sequence ID" value="BAJ65071"/>
        <property type="gene ID" value="ANT_30450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30450"/>
    <dbReference type="eggNOG" id="ENOG50337UE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1624084_0_0_0"/>
    <dbReference type="OMA" id="ITIPWQI"/>
    <dbReference type="OrthoDB" id="1528604at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="167" mass="18431" checksum="865863C622F4C2E4" modified="2011-04-05" version="1">MSILNWTPVARMRRNHALEHATLQVLAERHPHLMAAGYSDTRGFWIVGNLSTEEVYEAVEQALARLNAGEYRLAIHPNCGTNFAAAGFFAGTVGWLASLNMGRDLRSRLERWSVIVPLVTLALILAAPLGPLLQQRITTAPPHGLRVVEITRQVQGDLIAHRILTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W8</accession>
    <name>E8N2W8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30920"/>
    <dbReference type="EnsemblBacteria" id="BAJ65118">
        <property type="protein sequence ID" value="BAJ65118"/>
        <property type="gene ID" value="ANT_30920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30920"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504941_0_0_0"/>
    <dbReference type="OMA" id="VRQAFYQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="85"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="520"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="593" mass="65463" checksum="D451AECB8BE6E40D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X4</accession>
    <name>E8N2X4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tungstate ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30980"/>
    <dbReference type="EnsemblBacteria" id="BAJ65124">
        <property type="protein sequence ID" value="BAJ65124"/>
        <property type="gene ID" value="ANT_30980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30980"/>
    <dbReference type="eggNOG" id="COG2998">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061511_0_0_0"/>
    <dbReference type="OMA" id="LADRGTW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228634" evidence="1">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="31"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="31173" checksum="055938397AC19CFD" modified="2011-04-05" version="1">MDMLKRFWMLILALLVLSACQSAPAVPHLRLATTTSTQDSGLLDVLIPAFEQEYPVKVDVIAVGTGQALKLGEDGNADVLLVHDRAREDAFMAAGYGVRREDVMVNDFVLAGPAEDPAGVKQADSIAQAFQRIAQSRSPFISRGDSSGTHARELSLWKQAGINPQGENWYFSAGQGMGEVLTLADEKRAYTLSDRATFLRRRQNGLKLAILREKDEGLLNPYGVIVVSPSRGADLQVEWAETFTDWLISIPVQQKIAQFGVDEFGQSLFFPNSRLWREQNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N303</accession>
    <name>E8N303_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_31270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561494.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31270"/>
    <dbReference type="EnsemblBacteria" id="BAJ65153">
        <property type="protein sequence ID" value="BAJ65153"/>
        <property type="gene ID" value="ANT_31270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31270"/>
    <dbReference type="eggNOG" id="COG1808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675514_0_0_0"/>
    <dbReference type="OrthoDB" id="1707622at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="331"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="407" mass="42487" checksum="01D7929C9D8A7834" modified="2011-04-05" version="1">MSLPASEPIPLPEEELPPARRRRLRRMVIPEHHDEQSAFLDDLGERTTPGAEFFLSALLAGLVTGIALMLDSPALVVLAALLAPFMAPVLGMGVAGVAGSTGFLLRSLVSALIGGLIFFLTGTLTGIPARLFVLNGWVQLSYLLRLDGFSLLLLSLGTVFSTVLLARSTHQRPLVSSVAMAYALFLPLGAAGYGLTSGVPLPWYNGMVVFLIGLAVAALLGAITLVILGLRPLNGLSYLFTGAYMTIVVTALVIWLSGGIPTIQLPEMTPAQLPQAPAQVSAGSQPSPTPAELSATPSVSPTVTLTATATPTRTLIPTNTPTMTVTPQPTPVWARINVKGSNGAVIRAEPGYNAAIVKSLLNGIIVEVLSDVATADGATWVKIRTADGVEGWIVRNLLATATPAPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N306</accession>
    <name>E8N306_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potA</name>
        <name evidence="10" type="ordered locus">ANT_31300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561497.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31300"/>
    <dbReference type="EnsemblBacteria" id="BAJ65156">
        <property type="protein sequence ID" value="BAJ65156"/>
        <property type="gene ID" value="ANT_31300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31300"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="OMA" id="PFSIRPE"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015417">
        <property type="term" value="F:ABC-type polyamine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ65156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="38951" checksum="5A1779B2D1EA05F4" modified="2011-04-05" version="1">MAYLSLTGLSKRFGQTIAVEDFNLEIERGELVSFLGPSGCGKTTTLRMIAGFEYPTTGQIVLDGVEITHLPPNRRQIGMVFQSYALFPNLTVGENIAFGLKIAKRPAEEIRQTVEEMLNLIHLSNYGDRYPYQLSGGQQQRVALARALAIRPRVLLLDEPLSALDAKIRVELREEIRRIQQTLGITAVYVTHDQEEALSLSDRVVVMNAGHIEQAGTPFEVYNYPKTRFVASFIGQLNLLPVRVSDPARGVVLFKDTPIQVETPAALAGVSEATLALRPEELNLGEVVGRNHLRGKVLDVMFLGAIVRVRVDLQGDEVLADLFNERQMILPKVGEEVTLNFPPHACWIIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N361</accession>
    <name>E8N361_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase chain M</fullName>
            <ecNumber evidence="6">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoM</name>
        <name evidence="6" type="ordered locus">ANT_08410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559267.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62875">
        <property type="protein sequence ID" value="BAJ62875"/>
        <property type="gene ID" value="ANT_08410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08410"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_0"/>
    <dbReference type="OMA" id="GHMGFVL"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="131"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="499" mass="54869" checksum="2A9E9F0DB23E59AD" modified="2011-04-05" version="1">MDYTLILLTFSPLVGFLVLLFLKEEQKTALRWVALITSLVTFALSLWALAQFRMGEGGLQLVFDQPWFRLAESQVTFAMGVDGLGMLMILLTTFLTPLALLSTWSAVQERVKGFMIFFLLLETGMLGVFTAQDLVLFYIFWEFTLIPMYFLIGIWGGERRIYAAVKFFLFTMFGSVLMLLAILYLGLTAGTFSLSDLVLARQVFAGAQVWLWLAFALAFAIKVPMWPLHTWLPDAHVEAPTAGSVILAGVLLKMGSYGFLRFNLPLFPEATLQLAPYMAVLAVIGILYGAVVSFAQTDVKKLVAYSSVSHLGFVMLGIFALTAQGLAGSILQMVNHGLSTGALFLLVGMLYERRHTRQMSAYGGIWKVVPVLGAVMLFISLSSAGLPALNGFVGEFTILLGSFSSSTLGSPWFAGLGALGVILAAVYLLVMFERVFLGPVKHAENQSLKDMNLREVLTLLPIMIVILWIGLYPSFFFNLMNPTVSQLLATVQTAAMAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N363</accession>
    <name>E8N363_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_08430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559269.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08430"/>
    <dbReference type="EnsemblBacteria" id="BAJ62877">
        <property type="protein sequence ID" value="BAJ62877"/>
        <property type="gene ID" value="ANT_08430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08430"/>
    <dbReference type="eggNOG" id="COG1836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036918_2_1_0"/>
    <dbReference type="OMA" id="VISPWRW"/>
    <dbReference type="OrthoDB" id="737126at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="PTHR13353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="30739" checksum="F867F2F03EF3F271" modified="2011-04-05" version="1">MLLKLLLGVFFALLITGAAVRMRALSPSGFWAALALGTIIFGLGGLAWAIALLTFFVSSSLLSRLWGKQKRSLEEKFSKGHQRDAWQVLANGGLAGGMALLHAFIPHSPLPWVGFIAALAAANADTWATELGALSPVSPRLITTLRPVERGTSGGISLLGTLAALSGAVLLALVGVLFWNGFILPIPAGVPFVLVDLLGGVPMLPPPGGAGLWFMIFSLSGLAGSLVDSLLGATVQAIYRCPACEKETERHPLHTCGTRTHLLRGWRWMNNDAVNFLCTFSAFVLSILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N364</accession>
    <name>E8N364_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08440"/>
    <dbReference type="EnsemblBacteria" id="BAJ62878">
        <property type="protein sequence ID" value="BAJ62878"/>
        <property type="gene ID" value="ANT_08440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08440"/>
    <dbReference type="HOGENOM" id="CLU_920237_0_0_0"/>
    <dbReference type="OMA" id="IRWAGNQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027783">
        <property type="entry name" value="Bacterial_PH-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10882">
        <property type="entry name" value="bPH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_5" evidence="2">
        <location>
            <begin position="73"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="302" mass="33288" checksum="A0047C1E09AB347C" modified="2011-04-05" version="1">MELPALFTPPRRYGLIFLSLVTLILTGAGGLSIALSTSQQEQSRFTGLLLFGVILLVPVPLILYALYSLLRGQYILEREGLRLRWGLRAEDIPMSHIEWVRPMKELGFRVPLPLLRFPGAVLGNVYSHELGAIEFLASDPDSILLIATPEKIYAISPENVSAFMRAYRYVAELGSLQPISSQSIRPMVFLAHIWQDQIARRLILTGGGLFLALLVSSGIAILTRATVPLGYSPQGASLAPVPSIQILLLPVLGLLFLGTDWIIGVYFYRQERTLPAAYLLWGSGAVTLLLFVLATWIFMLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N369</accession>
    <name>E8N369_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559275.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08490"/>
    <dbReference type="EnsemblBacteria" id="BAJ62883">
        <property type="protein sequence ID" value="BAJ62883"/>
        <property type="gene ID" value="ANT_08490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08490"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_6_4_0"/>
    <dbReference type="OMA" id="AVIQGEM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="141" mass="14993" checksum="19D00FE597DB87D1" modified="2011-04-05" version="1">MFRKTPPQTPPPNPNMPVERVTSVLGPGILWKGNLRGTGGIRIEGTFEGDITLRGLVVVGETGKVVCQTLQANTVIVAGTVTGNITAEKLEIRGTGRVWGDVIISALATEEGGFLRGQVRMEEKIEFPLETSSSESSSETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N370</accession>
    <name>E8N370_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PglD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62884">
        <property type="protein sequence ID" value="BAJ62884"/>
        <property type="gene ID" value="ANT_08500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08500"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747312_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PglD_N" evidence="2">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="38638" checksum="D534BD38BE5BA65A" modified="2011-04-05" version="1">MGYGLPAGRTFLRNISSALRASALIACRSPGVLSPGGFARVMNSWYKKNMQFVPVCVPSLASSEIFVLKEWQVREGMWLLAGQPVATLLSGVEEIPVFAPQSGSLAGVHHHPGEVLLAGAVIGWIQQSDYTSGDYDPDAVLVYGGGGHGQVLLELIRQAGHFRLVGVVDDRLSRGETLLGVPVLGGAECLAEWRRKGVGLAVNGVGGIGNPLAREGVFTQLEQAGYFFPTLVHPRALVEPAAILHPGAQVLAMAYVGPCVEVGFGSLINVGAIASHHCRLGRVTNLSPGATLAGGVSLGDYTQVGMQATINVNIRIGKHCLIGNGATVKADVPDGTRVRAGHIWPPLHSSSQSGGTYVSQDSPANSPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N382</accession>
    <name>E8N382_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recO</name>
        <name evidence="9" type="ordered locus">ANT_08620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559288.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08620"/>
    <dbReference type="EnsemblBacteria" id="BAJ62896">
        <property type="protein sequence ID" value="BAJ62896"/>
        <property type="gene ID" value="ANT_08620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08620"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066632_1_0_0"/>
    <dbReference type="OMA" id="LCTQSET"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="258" mass="29518" checksum="77F9F1F1898EA27C" modified="2011-04-05" version="1">MPTPPRTLSVEAVVLRHSDWGEADRVLVLFTREQGKVRALAKGARKMLSRKAGHLEPFTHVKVLLAQGKDFWIVTQAETLNAFLSIRADLLRTAYAALVIELLDRFTSDDGENPALFQLLVHTLSRIATLEDPFIAVQYYHLRLLDLTGFRPQLFTCLRCGKEIQPENQFFDYQEGGVICPRCAPQVPTAKGISLNTLKYLRHLQRSTFEAAQRAQPSPAERNEMETILEGYFTYLLERRLNTPHFLNEIRREIAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A9</accession>
    <name>E8N3A9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two-component response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559315.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08890"/>
    <dbReference type="EnsemblBacteria" id="BAJ62923">
        <property type="protein sequence ID" value="BAJ62923"/>
        <property type="gene ID" value="ANT_08890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08890"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1955038_0_0_0"/>
    <dbReference type="OMA" id="AWRIIES"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="128" mass="14133" checksum="07EBC7EF45466BA0" modified="2011-04-05" version="1">MKPAILILDDDHPTLELYTRELSDEFVVFPCSSTPEAIPLLAREPLAAVVFEPAMENGGGWEFLQSLADFCIPRHIPIIFCSTQDEHRGEIPPEAGVFLVKPVLPNQLAKTLNQLLHPSSSKSKELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C6</accession>
    <name>E8N3C6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559332.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09060"/>
    <dbReference type="EnsemblBacteria" id="BAJ62940">
        <property type="protein sequence ID" value="BAJ62940"/>
        <property type="gene ID" value="ANT_09060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09060"/>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157042_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PTHR28242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="12939" checksum="7DF95C44F3879AFD" modified="2011-04-05" version="1">MINPEPLDKLRKFFGAEGESFVREVVTRYLQGVEGMLTDLERFLQQQDTVQFARVAHTLKGNSASVGAEEVSSLAAELEMMGRNGDLSGAPEKILLLRNAFSIAKNELEQMLRGKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E1</accession>
    <name>E8N3E1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative adenylate cyclase</fullName>
            <ecNumber evidence="6">4.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_09210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.6.1.1" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559346.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62955">
        <property type="protein sequence ID" value="BAJ62955"/>
        <property type="gene ID" value="ANT_09210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09210"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375391_0_0_0"/>
    <dbReference type="OrthoDB" id="769024at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029150">
        <property type="entry name" value="dCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14827">
        <property type="entry name" value="dCache_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="452"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="4">
        <location>
            <begin position="540"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="739" mass="81164" checksum="6E49DD28D75B84A0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I0</accession>
    <name>E8N3I0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559385.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62994">
        <property type="protein sequence ID" value="BAJ62994"/>
        <property type="gene ID" value="ANT_09600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09600"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046841_0_1_0"/>
    <dbReference type="OMA" id="MYLAITS"/>
    <dbReference type="OrthoDB" id="1155696at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="410" mass="45658" checksum="ED7D3317AEF83581" modified="2011-04-05" version="1">MKKIWIVLKHEVNTLLHNRSFLLGVFLLPLLGFIVLFVVGLLQRNPTLTGDTGTLPANVEIDTKGLVDYSGIVREIPQNLKNTVKKFDGEESALQALKSGEISAFFVIHRDYLKNGKVDFFAKNINAFSDSINHDPVDWLIQYNLFKDRPELLQRVHDPFNLQEETLASKKTQRDEDDPLAFAVPYGVTMIFYVLIFGTSSLMLSNIATEKQNRVVEILLTSVTPTQMMVGKMLGLGIMGLFQTLIWLIAARLLLPLGGRSISILQGVQIPPEILGWGILYFLLGYAIYASMMAWIGALAPNLREASQVTFIVAIPLIIPLMFHNALIFRPDSTISVIFSLIPLTSPVAMMTRLAATTVPFWQLALAAVLQALTAWLVLRIAAGMFRAQNLLSGQAFNLKVFFKALLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L0</accession>
    <name>E8N3L0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatidylinositol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63024">
        <property type="protein sequence ID" value="BAJ63024"/>
        <property type="gene ID" value="ANT_09900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09900"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080384_1_0_0"/>
    <dbReference type="OMA" id="DGNMARQ"/>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="201" mass="22123" checksum="C00EDF5EA9916DE0" modified="2011-04-05" version="1">MTFTDFLRKTFKNVLEPVAMFFNRLGIMPNTMTILGLAGNMVGAGLLAMGHIPAGGLVILLVGPIDALDGTMARLRGLPTEFGAFVDSVTDRYSELVIFLGLLIYFLREDLWLGALLVYLAAAGSVLVSYIRARAQSVGFETKIGLFTRVERFLVLVPGLIFNQPMISLALIALFGNITALQRIWHVRKQAYERTAIEKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W4</accession>
    <name>E8N3W4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_10940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559518.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10940"/>
    <dbReference type="EnsemblBacteria" id="BAJ63128">
        <property type="protein sequence ID" value="BAJ63128"/>
        <property type="gene ID" value="ANT_10940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10940"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_1_0"/>
    <dbReference type="OMA" id="IWAATRQ"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="36360" checksum="92206EC43B97657B" modified="2011-04-05" version="1">MVNYILRRLGYAVILTVLVSFVGFVIIKLPPGDFLTQKLEQLRARGDRSAESQIEALRAKYGLDKPFMEQYTTWAVGFLKGDFGESFAYERPVRDLIGERLWLTVILSVATLIVVWALAIPLGVYSAVRQYSLGDQIITTISFIGLGMPGFLLALLILYFAIVVLNQDVLGLFSPQYQDAPWSMGKFLDLLQHLWVPAIISAVTGAGGLIRIMRGNLLDTLGQPFIEAARARGLKNRDVIWKHGVRMAINPLIVILGSEALPGIISGNALVSIVLNLPTIGPLFVQALRQLDMYMAGTCLVFFTILLMLGNLLSDLMLAWLDPRIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N400</accession>
    <name>E8N400_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559552.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11300"/>
    <dbReference type="EnsemblBacteria" id="BAJ63164">
        <property type="protein sequence ID" value="BAJ63164"/>
        <property type="gene ID" value="ANT_11300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11300"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_6_0"/>
    <dbReference type="OMA" id="CHATDPN"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="86"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="564" mass="63898" checksum="C4A395EE4772FC62" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N446</accession>
    <name>E8N446_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559598.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11760"/>
    <dbReference type="EnsemblBacteria" id="BAJ63210">
        <property type="protein sequence ID" value="BAJ63210"/>
        <property type="gene ID" value="ANT_11760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11760"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884666_0_0_0"/>
    <dbReference type="OMA" id="THEGTID"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="148"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="33868" checksum="09475E6441D62C5A" modified="2011-04-05" version="1">MTKQQGITAALASALFLGVVPIFGKVAILSGFTPLAVIALRTGIAAILFMAFMAIWRRPFFYIYPVGLVGCLLAGFINGLGSVLYYTALGRINAGVGQLLYSLYPLFLAFWLLLDRQSITPLTALRLVISIVAVGLLLQTHEGTIDILGAVMMVGSAALYALHLVINQRILFEVPAPTVTIYTLLGMAATVVLAYLIGDRRPPADGVAWWAILSMALITFLSRFTLFLGIKRLGGLQTALLGLGEVLVTVVLSSILLNEKLTPQQWLGATLLCVSLILVGLDRIPPQKRVATGWLSWLNPPSIPTTDVPWQSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N464</accession>
    <name>E8N464_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ordered locus">ANT_11940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559616.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11940"/>
    <dbReference type="EnsemblBacteria" id="BAJ63228">
        <property type="protein sequence ID" value="BAJ63228"/>
        <property type="gene ID" value="ANT_11940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11940"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_0"/>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="255" mass="27272" checksum="11F3CF3E20143FD4" modified="2011-04-05" version="1">MLLTIDIGNTNLTLGLFEGDRLGAHWRLATDHERMPDEFGIQILGLLQHGGCSVAQLEGVCLASVVPPLTGRIVEACKAYLGKQPLVVDSTIKTGIQICYDNPMAVGADRIVDAVAVKALYGGPACIVDFGTATTFDAISAEGDYLGGAIAPGIGIAADALTRRTAQLPRINLERPPSVIGKNTVHAMQSGLLFGYVALVEGMIARFRKELGETMKTIATGGLAEIITRETDVIQIVNPWLTLEGLRMLWEMNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N480</accession>
    <name>E8N480_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12100"/>
    <dbReference type="EnsemblBacteria" id="BAJ63244">
        <property type="protein sequence ID" value="BAJ63244"/>
        <property type="gene ID" value="ANT_12100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12100"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536026_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="508" mass="55245" checksum="732E3C57F6D3708D" modified="2011-04-05" version="1">MAGKLSNLWTLVIIAGLLSGCVRGMNGAGQSPFSFGQKSQLALVETVTTGEEQSERVSTRVAPPQITPTPKESPTPAPPILYYTQAGDTLSALAARFGVAREEISSTQSLPENGLLDPGILLIIPDKLGETTSSEQVMPDSEIVFSPSALDFDINKYVTEAGGYLTTIQEWHSNGWNSGAASVYKVAIDNSINPRLLLAILEYQSHWVTGQPENLAQTDFPVGYLNYQKKGLFAQLSWAVQQLNIGYYGWREGRLTSLTFQDGTTMRLAPDLNAGSVAVLYLFSQLYDQPHWAAAVYGLESMPALYEKMFGSPWLRAQSVEPLFPATLTQPPMELPFRPGKPWSLTGGPHSAWGPDGARAALDFAPSTTEKDCYVSTDWVTAISSGLVVRSEYGVVVVDLDGDGFEQTGWAVLYLHIATNDRVPVNTWVNTDDRIGHPSCEGGQATGTHVHVARKYNGEWILADGPMPFVLSGWRAVAGEKPYQGALIKEEKTVKASIYGDYSSLISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D7</accession>
    <name>E8N4D7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative isobutyryl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_12670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559689.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63301">
        <property type="protein sequence ID" value="BAJ63301"/>
        <property type="gene ID" value="ANT_12670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12670"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128233_0_0_0"/>
    <dbReference type="OMA" id="VYTGLHQ"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="135" mass="14467" checksum="025F234A30A1B535" modified="2011-04-05" version="1">MIDRKIRVLIAKPGLDGHDRGAKIVAQALRDAGMEVIYTGLRQTPEMIAEAALQEDVDVVGLSILSGAHMALVPRVIELIRKNGQGDVKVFVGGIIPEEDIPLLKEAGVYAVYGPGTSTEVVIRDIQEAVLGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G7</accession>
    <name>E8N4G7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">mutL</name>
        <name evidence="8" type="ordered locus">ANT_12970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559719.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63331">
        <property type="protein sequence ID" value="BAJ63331"/>
        <property type="gene ID" value="ANT_12970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12970"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_2_0"/>
    <dbReference type="OMA" id="AHERIMY"/>
    <dbReference type="OrthoDB" id="764332at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="7">
        <location>
            <begin position="208"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="6">
        <location>
            <begin position="399"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="586" mass="64772" checksum="01616E486FF9FCE9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J7</accession>
    <name>E8N4J7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63361">
        <property type="protein sequence ID" value="BAJ63361"/>
        <property type="gene ID" value="ANT_13290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13290"/>
    <dbReference type="eggNOG" id="COG0160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_2_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="291" mass="31879" checksum="539ED3EC441D1B69" modified="2011-04-05" version="1">MGAVTFTASKNHYHRGFFPLMNGVTHVPYPDPYRPVLQSLPGEPYGETVVRYIEEQVLGKILPPEDVAGILVEPIQGEGGYIVPAEGFFPALRQLCDRYGILLIVDEVQSGMGRTGKWWAIEHFGVEPDIVCAAKGIASGLPLGAMIARKRLMKWPKGSHGNTFGGNPLSCAAALATIELIGSEYLQNAAEVGTYTLGKLREMSLRHPSIGDVRGIGLMIGIEFVKDRQTRHPDEKFRDKVVDLAFEHGLLLLGCGKSVIRISPPLCITRQEVDEGLEILERAIYLAEEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K8</accession>
    <name>E8N4K8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_13400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559759.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63372">
        <property type="protein sequence ID" value="BAJ63372"/>
        <property type="gene ID" value="ANT_13400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13400"/>
    <dbReference type="eggNOG" id="COG3870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143974_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010375">
        <property type="entry name" value="CdAMP_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38456">
        <property type="entry name" value="PTHR38456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06153">
        <property type="entry name" value="CdAMP_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="12926" checksum="45CF55F995FF7046" modified="2011-04-05" version="1">MSQQPRSNIDRMVLIVAAAEQSGQLTTELLKAGFSLTVISPREGFLGFGATCLLLGIDSQRMQELLEIVQKTCGKRRQFVPAQGHLVLPEGLPPMMIEAEVGSAYVFSMEVEHFEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4M4</accession>
    <name>E8N4M4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative OmpR family two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_13580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13580"/>
    <dbReference type="EnsemblBacteria" id="BAJ63388">
        <property type="protein sequence ID" value="BAJ63388"/>
        <property type="gene ID" value="ANT_13580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13580"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="QIISEVW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="150"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="150"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="29028" checksum="9B2331B0AF9D57DF" modified="2011-04-05" version="1">MNEPVTLPLDQTQPGIDLDEITKASRQTILVVEDEPDTVFLLKQILRMAGYNVLSAVNGYEAIQKCMDIHPDLILLDLMMPEMDGWQTYQYLREATDVPVIVISAIHNKEDVVRALRIGMDDYITKPFVNAEVVARVQAVLRRARPTKQSDRLVFPHEGLIINFTTQEVIYQQKHIQLTGKEFAILACLAKHAPEVVHYKTIAEEVWGKDSPQVRNRIKYLIYLLRQKLGNVIQTPELIQNIDRLGYKLLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S1</accession>
    <name>E8N4S1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63435">
        <property type="protein sequence ID" value="BAJ63435"/>
        <property type="gene ID" value="ANT_14070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14070"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_2_1_0"/>
    <dbReference type="OMA" id="PLKLYYN"/>
    <dbReference type="OrthoDB" id="1380748at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="289" mass="32161" checksum="625FEF65E64FB85E" modified="2011-04-05" version="1">MKIMDMETKRALLAVLAHPDDETFGMGGTLALYARQGVDVYLICATRGEAGEVEKEHLQGFSTVAERRESELRCAANILGLKGVFFLGYRDSGMPGSVDNFHPQALCVQPVEEVAERIASLILEIKPQVVITFDPIGGYRHPDHVAIHQATVRAFERLAMLQQEGKAVNPVKKLYFHTIPRTLLRLIVLAMKLRGKDPRRFGKNGDIDLASIAAEQFPIHAVVDYRQVARVRERAVACHVSQGGASLTGVGIFAQIRRWFFSRDVFMRAYPPAGKGSPKENDLFEGIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S7</accession>
    <name>E8N4S7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N_BRCA1_IG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14130"/>
    <dbReference type="EnsemblBacteria" id="BAJ63441">
        <property type="protein sequence ID" value="BAJ63441"/>
        <property type="gene ID" value="ANT_14130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14130"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833260_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="N_BRCA1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228176" description="N_BRCA1_IG domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="N_BRCA1_IG" evidence="2">
        <location>
            <begin position="93"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="333" mass="36912" checksum="80C69D8211A33191" modified="2011-04-05" version="1">MRVTIYLLLLFNLWLVSCSMATPRVSMPSHSEQPTAKTIPVDQKSSFILPTELTYQAETYSSRQEAVSEGMRISPRDHLPCDRAEAGAPIDVTVPDDFAFLAGERFVKVWKLRNAGSCSWTSDYSVVWFSGAPLGLQTSERLKQVVAPGEEVEIAVEMMAPDVPGVYQSHWKMQNARGQLFGIGPEGESPFWVRIQVLPRPTSTPEAMVTPFVPTPGIYRLGSFELSPGDSLDLDSGLFNPEQGGDFVFEILDGNYWIKPQGNSYLAVTSLFSPGYQDCRLAVLAQEAILATQEIQGSFMCLRTNEGRLGSILLSLDFERNQLSGAYILWELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U6</accession>
    <name>E8N4U6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative diacylglycerol kinase</fullName>
            <ecNumber evidence="12">2.7.1.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dgkA</name>
        <name evidence="12" type="ordered locus">ANT_14320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="12"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559842.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63460">
        <property type="protein sequence ID" value="BAJ63460"/>
        <property type="gene ID" value="ANT_14320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14320"/>
    <dbReference type="eggNOG" id="COG0818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112343_2_0_0"/>
    <dbReference type="OMA" id="SFRYAAQ"/>
    <dbReference type="OrthoDB" id="2028997at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14265">
        <property type="entry name" value="UDPK_IM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033717">
        <property type="entry name" value="UDPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01069">
        <property type="entry name" value="DAGK_PROKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="128" mass="14386" checksum="B25048FBC2C30999" modified="2011-04-05" version="1">MDEFIRLRLRAFRYAFSGWWYVIRTQRNAWIHAIVSVLTILVCIVLRLPARDWAVIILTIALVWISEFLNTALEAVVDLAMPIHHPLARVGKDVGAAAVLISAITAVLVGIFILGPALWVKIAPVFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W8</accession>
    <name>E8N4W8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559864.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14540"/>
    <dbReference type="EnsemblBacteria" id="BAJ63482">
        <property type="protein sequence ID" value="BAJ63482"/>
        <property type="gene ID" value="ANT_14540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14540"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007015_0_0_0"/>
    <dbReference type="OMA" id="RCHIKST"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="276" mass="31613" checksum="DC42B09F701F07A8" modified="2011-04-05" version="1">MSKIWGYRCTNNQLEKLLLPEQGEVDDLVRKYGEGVYTTLRTYHRNRVLFLKEHIYRLEHSAELSGVFLTVSEASVRDLIRALIQEANGKDIRIRLIVPFSSPETVIGMATFLTPPSMEDYRLGVAVETRRMHRDNPQAKVTEFIQKASEIRKQIGKEIHEVIMVDENGRLLEGLSSNFFAVHQGKVWTAGQGVLPGITRELVLKCVQELNLPLNLEGFPYQRLYEIEEAFLTSTSRGVLPVRKIDQYTVPQTPGKITTTLSTRFQERLNQLLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W9</accession>
    <name>E8N4W9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14550"/>
    <dbReference type="EnsemblBacteria" id="BAJ63483">
        <property type="protein sequence ID" value="BAJ63483"/>
        <property type="gene ID" value="ANT_14550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14550"/>
    <dbReference type="HOGENOM" id="CLU_2535286_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="2">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="83" mass="9142" checksum="17E115CE5BEDA7C3" modified="2011-04-05" version="1">MLSAEMIRMLLESYDISVWIVPESAGIAYGLTVGPLGAVDILVAEEDAEKAKDILRKYENGELSINEEQDEPARNNDSENSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N531</accession>
    <name>E8N531_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purB</name>
        <name evidence="12" type="ordered locus">ANT_15170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15170"/>
    <dbReference type="EnsemblBacteria" id="BAJ63545">
        <property type="protein sequence ID" value="BAJ63545"/>
        <property type="gene ID" value="ANT_15170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15170"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_1_1_0"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="370"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="470" mass="53637" checksum="0DAEACCAE5110228" modified="2011-04-05" version="1">MTPNYTLYQSPFSWRYASTEMRTLWSEEYKRKLWRKIWVVLARVQSEFGLFSSQVLKELEEKQNEIDLERSLEIEKTIHHDLMAELQCFSEQCPNAGGYLHIGATSMDIEDNAEAIRLREALEILVKKLDDLLGLTAQKIRLYSEIPSLAFTHLQPAEPTTLGYRIAGFAQELLIHSQKMRDLKKNLRGKGFKGAVGTAASYVEILGPDHFDEFEKKMGEALQLSFFPVSTQTYPRIQDYQVLVTLAGLGATLYKFAFDLRLLQSPLYGEWSEPFSVKQVGSSAMPFKRNPIQAEKIDSLARLLASLPQVAWENAAHSLLERTLDDSANRRTILPEAFLIADELLLTAIRILKGIKINTNSIERNLQVYAPFSASERLLMRLVQKGANRQEMHEVIREHSMQAWLEVTAGKPNPLFTLLQSDERIKIFLNAEEISECQNIQSYTGIAARRAQQIAEDIEKYLQASETYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N553</accession>
    <name>E8N553_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_15390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559949.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63567">
        <property type="protein sequence ID" value="BAJ63567"/>
        <property type="gene ID" value="ANT_15390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15390"/>
    <dbReference type="HOGENOM" id="CLU_1493243_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="21058" checksum="D2A699B18347F8D9" modified="2011-04-05" version="1">MSEQEQIRYLPFHAINEFMLDEYREKVVRFVFENLGNLSSSRRNGILSIFKKQVKIPGFRDSSLAPLPLKIKQGIVLFQKNADFVAQVLQAWVELHHDLKERVHAMLVSRGWKNLLPPELDRSKLPGFQVEWPKSETYEVLDQSFYEQNPGVEAPNDDIRLMVVWLVNALPYELFEENSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N563</accession>
    <name>E8N563_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ordered locus">ANT_15490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15490"/>
    <dbReference type="EnsemblBacteria" id="BAJ63577">
        <property type="protein sequence ID" value="BAJ63577"/>
        <property type="gene ID" value="ANT_15490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15490"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_0"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="13"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="623" mass="69764" checksum="2FF2455D2E36BD71" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N586</accession>
    <name>E8N586_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_15720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63600">
        <property type="protein sequence ID" value="BAJ63600"/>
        <property type="gene ID" value="ANT_15720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15720"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031877_0_0_0"/>
    <dbReference type="OMA" id="GWGRQFF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="133"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="471" mass="53120" checksum="5116ECB699C9FFAF" modified="2011-04-05" version="1">MSVFFDKWLSSITKKRLSLPNPGIYHYARKNNGTKMRLHLRIHPDWSGVLVINANRVFHLNPSATLMTYLWLENVSSKDAVKNLARWFATSSDTIGQDYEKISEQICALTQSENACPICDLELETTIPFNDTPFAPYRMDLALTYRCNNQCSHCYNARSRNFPELPTEKWKTIIQKLWDIGIPHLVFTGGEPTLRHDLPDLIEFAEKIGMITGLNTNGTCLSNREYLKKLVNAGLDHVQITIESHLEKIHDEMVTHSGAWYLTVEGIRNALETSLYVMTNTTLLKQNTPFILETIQFLQKLGVPTIGLNALIYSGHGKTVGTGLTEPELTTVLESVNQLTRQTGQKLIWYTPTHYCNFNPLEMGLGVKGCTAARYAMAIEPNGDVIPCQSYYSSLGNLLFQSWEEIWNHPLAASIRNRSALPNECKQCQILDICGGGCPLAKEHDPNFKPIPVLSEIEQISASVRVQHGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C7</accession>
    <name>E8N5C7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M20 family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560021.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63641">
        <property type="protein sequence ID" value="BAJ63641"/>
        <property type="gene ID" value="ANT_16150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16150"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051308_0_0_0"/>
    <dbReference type="OMA" id="DDTRGLA"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="373" mass="41120" checksum="E147CF79C1E5DCC4" modified="2011-04-05" version="1">MTINLAEIYQKVIEDTCTIQQIPAPTFHEQKRAEFLSLRWKETDNLMPETDEAGNVLVFLPGQLDKFQVVISAHMDSVFPLDVPLHFRRDGNRIYGPGIGDNALGCATLLNLPLLIKDIPSPRGNIWLAGTTGEEGLGNLKGMKALLSRFHDTPTIYISLEGMGLGCILHRGLGVNRYRIEVHTPGGHSWTDAGSPSAIHEVVRLSRKLLDLPLPLSPRTTLNIGTIQGGTSINTIASHAAIEVDVRSEMLDTLKRMDELILDTARRFETDSVEISISSIGHRPAGSISEYHPLVNLLERILLHLNISPRREIASTEANLPLSYGIPAVTIGITSGAKAHTLEEYIECQPIEKGLLQLLQLIKQIWETSIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5F5</accession>
    <name>E8N5F5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560049.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63669">
        <property type="protein sequence ID" value="BAJ63669"/>
        <property type="gene ID" value="ANT_16430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16430"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_0"/>
    <dbReference type="OMA" id="RSGFEIC"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="131" mass="14825" checksum="CA30577F539F10E2" modified="2011-04-05" version="1">MEEANKKTVVVYIEDDLDLIDLVTRILTPRGFEVKGAHGGQKGLDLIFHDPPDLILLDLMMPGMDGWEVYQQLRANPSTKHIPVIVITAKAQDIDRVLGLHIAKVQDYICKPFRPQELLDSVDRVLREVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I4</accession>
    <name>E8N5I4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ubiquinone/menaquinone biosynthesis methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ubiE</name>
        <name evidence="3" type="ordered locus">ANT_16720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560077.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63698">
        <property type="protein sequence ID" value="BAJ63698"/>
        <property type="gene ID" value="ANT_16720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16720"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1264757_0_0_0"/>
    <dbReference type="OMA" id="CATFPAE"/>
    <dbReference type="OrthoDB" id="1432164at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="24665" checksum="77F1ADDA6AAF99AE" modified="2011-04-05" version="1">MNWRKRILYFLFDLLYHPFAWAYDFVAAIVSLNSWQKWVTSIIPFLPGETVLELGCGTGYLMRALRSSRKIIGIDLSPQMIRQTRKRVNIHNNAFPFLIQADGRAIPLKKETFDHVVATFPAPYLFEEATLRSVQFALKPGGSMVVLLSAVPPLISPLEHIHSWVMRKGGVFEASQVFFNIIREKAQQAGLTPVHLEWTPCLSGKILVLVAVKSVQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J3</accession>
    <name>E8N5J3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560086.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16810"/>
    <dbReference type="EnsemblBacteria" id="BAJ63707">
        <property type="protein sequence ID" value="BAJ63707"/>
        <property type="gene ID" value="ANT_16810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16810"/>
    <dbReference type="HOGENOM" id="CLU_171854_8_2_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="48" mass="5146" checksum="B21C3DBC71D85652" modified="2011-04-05" version="1">MLIAQKERGQGLLEYALIIILVAVIVLVVLALLGPAVGQMFSNVVQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L9</accession>
    <name>E8N5L9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560112.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63733">
        <property type="protein sequence ID" value="BAJ63733"/>
        <property type="gene ID" value="ANT_17070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17070"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_0"/>
    <dbReference type="OMA" id="EDHHPYN"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05257">
        <property type="entry name" value="Arna_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045869">
        <property type="entry name" value="Arna-like_SDR_e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="37075" checksum="78A4BFA988576ADD" modified="2011-04-05" version="1">MEQNLYKNSRVLVTGAGGFIASHLVEQLVIQGATVRAFVRYNSRGDIGLLRFIPEQVLRQVEVRFGDLRDYNAVVGALKGTDVVFHLGALIAIPYSYLHPREVVETNVLGTLNVLQACREIGISRLVHTSTSEVYGTGLYTPMDEKHPLHAQSPYAASKIGADKLVESFYCTYDLSAVTVRPFNTFGPRQSARAVIPTIISQALTSERIRIGNLTTKRDFTFVLDTVRGFLLAGSVPGVEGETFNLGTGKEVTVGELIDRVAQILGKELIVEQERERFRPEKSEVMRLLSDFSKAQMRLGWAPEWTLSKGLKQTLEWIQEHLSSYPNSVYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N2</accession>
    <name>E8N5N2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560124.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17200"/>
    <dbReference type="EnsemblBacteria" id="BAJ63746">
        <property type="protein sequence ID" value="BAJ63746"/>
        <property type="gene ID" value="ANT_17200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17200"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_5_2_0"/>
    <dbReference type="OMA" id="GCALEIR"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="81" mass="8699" checksum="8F51320ECB6927C5" modified="2011-04-05" version="1">MQVKVKLYATLVRYVEGVRAGQPISVNLPDGATIRDVLTILKIPEEEVKVAFVAGRACSWDTRLKDGDEVGIFSPIGGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N8</accession>
    <name>E8N5N8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_17260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17260"/>
    <dbReference type="EnsemblBacteria" id="BAJ63752">
        <property type="protein sequence ID" value="BAJ63752"/>
        <property type="gene ID" value="ANT_17260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17260"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_0_0"/>
    <dbReference type="OMA" id="PLVPYNA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="452" mass="50894" checksum="7530F0BAB104CCA4" modified="2011-04-05" version="1">MYMVYMSDEEILSASLETNFWTWSAQGKVNPIPVKRADGVYFWDVHGKRYLDFNSMVMCVNIGHGNQRVIEAIANQARELAFAGPGMATRPRAVLGKLLREIVPEGLTHFLYTLGGADANENAIKLARAFTGRSKILTRYRSYHGATHGALALTGDPRRVAWEPYVMPGVVHFLDPYRYRSTFHLNRPEVSEEQFSQDYLNHLEEIIQYEGPHTIAAVLLETVTGTNGVIIPPKGYLEGVRAICDRYGILLICDEVMSGFGRTGRWFAVDHWGVKPDLMTMAKGLTSGYAPLGAVAMRQEIYEFFMDREYVGGLTFNGHPISLAAAAAVIEVMKDEHIVEHAAEMGVVMKEMLEELVERHPSVGEVRSIGLFGVIELVKDRKTREPMAPFNGFSAEMNALRKYILEQGVFLYTHWHTILLLPPLIITPEQLREGFEVIDRALEITDRMVKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T6</accession>
    <name>E8N5T6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_17740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17740"/>
    <dbReference type="EnsemblBacteria" id="BAJ63800">
        <property type="protein sequence ID" value="BAJ63800"/>
        <property type="gene ID" value="ANT_17740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17740"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926298_0_0_0"/>
    <dbReference type="OMA" id="YELEMNL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="37430" checksum="A7A7A80814B81E2E" modified="2011-04-05" version="1">MSAEPPLRKTLTDQDIQQITRTEELAYELKVEEVMSRDVKCLHPDMLMHQALELFRNERISGAPVTCDSTLCGVLSMEDLIRCLLNQDLDARISAYMTPNPFYIHPADPVIEALKLFVSTRHGRLPVIDQDRKVVGILTKGDITVGLLKALQKDFQAEEIRRYRASHLFEDIVSDRTSLILRYQIKPRDFTHGGAASSNIKRALLRLGASPNIARRCGIAAYEAEMNLIIHTTNGGVIRVEIEPHQITLEATDDGPGIRDIDLAMQPGYSTATEEIRELGFGAGMGLVNIRRCVDQFRLESTWGKGTRLRVRIFMNPEESSKSTSENERENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V1</accession>
    <name>E8N5V1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypE</name>
        <name evidence="4" type="ordered locus">ANT_17890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63815">
        <property type="protein sequence ID" value="BAJ63815"/>
        <property type="gene ID" value="ANT_17890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17890"/>
    <dbReference type="eggNOG" id="COG0309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049733_0_0_0"/>
    <dbReference type="OMA" id="CGNGGKE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="90"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="202"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="376" mass="39940" checksum="C78142E3214ABEF6" modified="2011-04-05" version="1">MFSFLSLFQGSQNMNDSNNLQSLPEYEGLACPLPLPHNDQIVIGHGSGGKMTHDLIRKVFQKYLSSPALLAGNDFASLVLPQLSEQQGTLIVSTDSHVVFPLFFPGGDIGRLAVAGTVNDVAVSGGIPLYLTASFILEEGFPVSLLEKILASMQQTAEEAGVVFIAGDTKVVERGKMDGVFINTTGLGWLPSNVNIHGANAQPGDVVILSGSMGDHGMAILTARGELGIQSAIESDVAPLNHLIRHLLEAAPNTHVLRDPTRGGVATTLNEIALQSRVGILLEENALPVKPVVRSMCEMLGFDPLYIANEGKVLAIVPEQEAQPALDALRSHPLGSQAQVIGKVITEQPGKVLMRTLIGSTRIVESLSGEILPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N637</accession>
    <name>E8N637_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endoglucanase</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_18750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18750"/>
    <dbReference type="EnsemblBacteria" id="BAJ63901">
        <property type="protein sequence ID" value="BAJ63901"/>
        <property type="gene ID" value="ANT_18750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18750"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018668_1_0_0"/>
    <dbReference type="OMA" id="THQGAEW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="104"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="392" mass="44679" checksum="54D6F384EABDB0C1" modified="2011-04-05" version="1">MKMNKTQIPSFFSPLWMVLIILTLFGCAVRPDADISVTTDKAGTRLSGSLSSTKTVPPFPSVPGNTSTPVPSVISGADEHVFEQNRRLGRGINLGNALEAPSEGEWGVTLNETFFLLISSAGFDSVRIPIRWSAHADSEFPYTIDPVFFKRVDWAIEQAFRNNLRVVINIHHYDELMENPRLHHDRFLAIWEQIALHYQDYPESLYFELLNEPHGPLSVFWSDLAAEAIRTIRKTNPERTLIVGPGNWNNMGALQDLTLPETDRNLIVTVHYYSPFEFTHQGAEWVSGSEKYLGTPWEGKEWEKKAIDTDFDLALMWAQKYHRPIFLGEFGAYSKADMDSRKRWTEYVARSAEKRGFSWAYWEFCAGFGVYNAQTHVWVEPLLTALIPSALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N686</accession>
    <name>E8N686_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">deoC</name>
        <name evidence="4" type="ordered locus">ANT_19240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63950">
        <property type="protein sequence ID" value="BAJ63950"/>
        <property type="gene ID" value="ANT_19240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19240"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_0"/>
    <dbReference type="OMA" id="KRGIGNE"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="250" mass="27163" checksum="E4679DD70A55FFE6" modified="2011-04-05" version="1">MKEILTLLDEFERVLPPLVLPEELSSNKPFSSWIDHTLLKPEATPQQIEHLCEEAKQYQFASVCVNPVYVSQVARALQGTPVKVCTVIGFPLGATPTRVKVFETRTCLEMGAQEIDMVLPIGHLRAGEFEYVLEDIYSVVEAAHAQDALVKVILETALLDHRQKIAGCLLSQKAGADFVKTSTGFGPGGATVEDIELMRRVVGPNTGVKASGGVRNLDIARAMLHAGANRLGTSSGVIIMKELEEAKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6F2</accession>
    <name>E8N6F2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrC</name>
        <name evidence="11" type="ordered locus">ANT_19900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560387.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64016">
        <property type="protein sequence ID" value="BAJ64016"/>
        <property type="gene ID" value="ANT_19900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19900"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_0"/>
    <dbReference type="OMA" id="PTVKMMR"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="74"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="391" mass="42397" checksum="4FC90EC471449223" modified="2011-04-05" version="1">MPFSYLSHLECSECGKAFSPSLPQTICPDCQAPLFARYDLPSLAAQVPREKMDNIHSMWCWHVVLPVLTQEHVVTLGEGGTPLLKLERLASKYNLKALYLKDEGLNPTASFKARGLSAAVSKARELGIRQLMIPTAGNAGGALAAYASRAGMSAWIAMPEDTPKANVEETAITGARISLVPGVISDAAKFLQSHAEKGKWFDVSTFKEPYRLEGKKTMGYEIARDLGWEFPEVILYPTGGGTGLVGIWKAYEELLELGWLKNPRPPRLYAVQSEGCAPVVKAFKNGESDVAFWENASTHASGLRVPRPFAGKAILRTLRNSKGGAISVEEDSIRKAQKDIAQLEGIFTAPEGAATLAGLEILLAEGEIQPDERILLLNTGSGLKYLDTLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXE4</accession>
    <name>E8MXE4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_19990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560396.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19990"/>
    <dbReference type="EnsemblBacteria" id="BAJ64025">
        <property type="protein sequence ID" value="BAJ64025"/>
        <property type="gene ID" value="ANT_19990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19990"/>
    <dbReference type="eggNOG" id="COG2605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048558_1_0_0"/>
    <dbReference type="OMA" id="LEIHHDG"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001174">
        <property type="entry name" value="Galkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014606">
        <property type="entry name" value="Heptose_7-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036406">
        <property type="entry name" value="Hept_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00960">
        <property type="entry name" value="LMBPPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="226"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="324" mass="36111" checksum="1194771FD544F980" modified="2011-04-05" version="1">MIIVQSPLRISFFGGGTDFPDYYLQEEGCVLSTAIDKYIFVVIKQRYDDKLRIGYTRTEMVDQVDEIQHELIREALKLTGIKKGVEITTMGDIPAGSGLGSSSAVTVGALHAMYTFLNENVPASRLAREACEIEIERLKKPIGVQDQYISAFGGLRFIEFKRDGSIHVHPVVLEPALKRRLNESLLIFFTGVTRQADSILSEQQQNIQQRLTILREMKDMAKTAHQELLRGNVDVLGNLLHESWLLKKQLASGISNGMIEEAYQAARSAGALGGKIAGAGGGGFLLLYCPYEKREAVRKALSNMKELPFQLEPDGSKVIFNYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL9</accession>
    <name>E8MXL9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_20740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64100">
        <property type="protein sequence ID" value="BAJ64100"/>
        <property type="gene ID" value="ANT_20740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20740"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_0"/>
    <dbReference type="OMA" id="RAHRGYE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="203" mass="23557" checksum="72DF338A72BB5B12" modified="2011-04-05" version="1">MSKLPSSVGVNPDEEKNPSSLESLSEDEVIALAARGDTEAFSVLYQRYVTRIYNYIYYRTGNPFEAEDLTSRVFHRALNHIQHYDNRGIPFSAWLYRIAHNLVANWHRDSNRHKEVPIEDQPRLVHHAEPPEHAVMNNQELESLMKVIRKLPAERQQLLILKFVEGLSNAEIAVIMMRSEGAIKSLYHRTLLALRDEIQKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP2</accession>
    <name>E8MXP2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_20970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560493.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20970"/>
    <dbReference type="EnsemblBacteria" id="BAJ64123">
        <property type="protein sequence ID" value="BAJ64123"/>
        <property type="gene ID" value="ANT_20970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20970"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="OMA" id="FGVRAHR"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="280" mass="31101" checksum="F71CF5699B41D584" modified="2011-04-05" version="1">MTKSSQGLFFFPPHLPHQTDKPIVSVKGVSLIYSNGPALENIHFDVVVGERLAVIGPNGAGKSTLFKIIAGVLPPTEGRVEVYGNEPGKHICIAYVPQRSQVDWSFPVSVADVVMMGRIGKIGIFRRPTRKDWEIVYQALETVQLQDYAKRQIRQLSGGQQQRVFIARALAQEAELILMDEPFTGLDFPARQTILNILDILKEKHVTVLVALHDLKTAAEHFDRILLLNHRLIAIGQPSEVLIPSHLLYAYGGQLSLIPAEEGTWAMEDTCCEEGEHSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV5</accession>
    <name>E8MXV5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21600"/>
    <dbReference type="EnsemblBacteria" id="BAJ64186">
        <property type="protein sequence ID" value="BAJ64186"/>
        <property type="gene ID" value="ANT_21600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21600"/>
    <dbReference type="HOGENOM" id="CLU_3195434_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="45" mass="5340" checksum="E98347C8D8BA8EEE" modified="2011-04-05" version="1">MLIITPQELQTDRLVNQLAKTWQEHGLDLETMLKTLREVRSEYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW6</accession>
    <name>E8MXW6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64197">
        <property type="protein sequence ID" value="BAJ64197"/>
        <property type="gene ID" value="ANT_21710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21710"/>
    <dbReference type="HOGENOM" id="CLU_2646596_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="76" mass="8361" checksum="74D26FCE5F787639" modified="2011-04-05" version="1">MDKHELQEQLGGELVTELVAGVDDAALEAALLDEKDPLARDLQTAVQAAVDAGRKQARQIVVTALERELNRRRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY1</accession>
    <name>E8MXY1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21860"/>
    <dbReference type="EnsemblBacteria" id="BAJ64212">
        <property type="protein sequence ID" value="BAJ64212"/>
        <property type="gene ID" value="ANT_21860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21860"/>
    <dbReference type="HOGENOM" id="CLU_1486136_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="181" mass="20866" checksum="906553F61115A41E" modified="2011-04-05" version="1">MTRSQNPDNLQNRPAWKLFVRLFFWLTLLPAGSWLIVSSFIDPAHRNFLFFWRFLITLALFGLLFHFRVFRAVHEGLHAIAAHWSAVPPSFITARDTYVFVKITDKKSWYKITLYPLLFPIAVFLLFIPWNWEIGLYLACILAAGSCQDLANLVMVSRTPGNWVSDTAEGLFVYNTPPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY27</accession>
    <name>E8MY27_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ordered locus">ANT_22320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22320"/>
    <dbReference type="EnsemblBacteria" id="BAJ64258">
        <property type="protein sequence ID" value="BAJ64258"/>
        <property type="gene ID" value="ANT_22320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22320"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_2_0"/>
    <dbReference type="OMA" id="IAMPGKA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="378" mass="41963" checksum="A39C52DED1E7D6C0" modified="2011-04-05" version="1">MKQARRRQSRTCLTFVMTILLGTICLGGLAILVGFGLIPQMANDAFGAPVSTLSPFQRTYLSLQLLIHQDALTLPVNPEAQPVQFLVKEGETANSVAMRLYDLGLIRDREAFRAYLIYSGRDTRIRSGTYTLSAAMNALEIAGKLQDPLSQEVVFNILPGWRAEEIAASLATSGINVNAESFLEAVRQGKKGEEPLASYEGFLFPGSYRFLRDVTAEEMVQAFYHEFERSVTEDLRNAYAQRGLSLVEAVTLASIVQREAVVTEEQPLIASVFYNRLQQNMKLDSDPTVQYALGYGEAWGTWWKVPLTLNDLSVDSPYNTYLYPGLPPGPICNPGLSALQAVAYPAETPYFYFRAACDGSGRHLFARTFEEHLQNACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY30</accession>
    <name>E8MY30_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_22350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560629.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22350"/>
    <dbReference type="EnsemblBacteria" id="BAJ64261">
        <property type="protein sequence ID" value="BAJ64261"/>
        <property type="gene ID" value="ANT_22350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22350"/>
    <dbReference type="eggNOG" id="COG3394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064244_0_0_0"/>
    <dbReference type="OMA" id="DFHCLAD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="33215" checksum="523BF7259AAB6536" modified="2011-04-05" version="1">MKPNPLLKKLGFSDSDRVVLIHADDVGMCQASVQAFADLTAFGLVSCGAVMVPCSWAPLAGAYAREHPEADLGVHLTLTSEWQNYRWGPLSTRDPRSGLLDEEGYFPRTVEPVQAKGNPRAVRREIEVQLEHARRLGINPSHVDTHMGTVIHPKFLDAYIGTARKNRLPAMIVRQDEASLRQMGLNALTAKIAARWIERLEREGFPMLDDIVMMPLGQWENRLEVAKEVFKAVKPGLTHFIIHPAVDSPEIRAIAPDWRARVADWQVFQSQELRQFLQAEGIQIIGYRAIQSLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY60</accession>
    <name>E8MY60_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_22650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560659.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64291">
        <property type="protein sequence ID" value="BAJ64291"/>
        <property type="gene ID" value="ANT_22650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22650"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="ATMILQF"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="188"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="247"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="478" mass="52640" checksum="BF5114B96F0F63D2" modified="2011-04-05" version="1">MFSSLRSRLWLSYALLIGVSIGVVAVTLLVAFLRNPLVYRSGLPRLREAINTATPQLEKAIPQGMKAVEEELQMASRRTGLRYFLISPSGKLFYDSGKGQEGGIALLALRRIILNENEVPSGLYRDQNGKRWLYLSQRLPEGMILVVAMPTRDLPLNTLIRNEMVMPVVLAGLCGLGLSVVLALAMGAWIARPLQKMQKEAAQLAEGKAVGVSEEGPQEVRELAHSLNEMMRKVQAGQRAQRDFIANVSHDLKTPLTAIQGFAQAILDGTAQSPETLRNAATVIYNEASRMYRLVLDLLTLARFDAGTADLVFEKVDPQDLLRETVRRFSPLAQKAGVILRLEDASLPVLFADGERLMQALANLMDNALKYTPAGGTIVLRGKVEEGHLLLEVQDTGKGISPEEQTRIFERFYRGNPSRSQDGEQSSGLGLPIVREILRAHGGEVRLYSEVGKGSCFTLVLPLQGSEVHREHQGGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY69</accession>
    <name>E8MY69_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64300">
        <property type="protein sequence ID" value="BAJ64300"/>
        <property type="gene ID" value="ANT_22740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22740"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145413_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="16947" checksum="82D41F6F31802579" modified="2011-04-05" version="1">MDDILTRALFALIAGLSGWGVYSFLKSRSLKQARKISTSMSFPTGEPFILYFTTPDCVPCRTIQRPALQSLKTTLGEQFRIVEINAYEHPDLVKQYGILSIPTTFIFDSAGVPRFVNHGVIRKERLLTQLQQVMTFESSTMAIQNRQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY91</accession>
    <name>E8MY91_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RE_EcoO109I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558434.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00020"/>
    <dbReference type="REBASE" id="32144">
        <property type="entry name" value="AthUNI1ORF30P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62036">
        <property type="protein sequence ID" value="BAJ62036"/>
        <property type="gene ID" value="ANT_00020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00020"/>
    <dbReference type="eggNOG" id="ENOG502Z8WB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100153_0_0_0"/>
    <dbReference type="OMA" id="KSGPNWG"/>
    <dbReference type="OrthoDB" id="1303188at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032793">
        <property type="entry name" value="RE_EcoO109IR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14511">
        <property type="entry name" value="RE_EcoO109I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RE_EcoO109I" evidence="1">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="248" mass="28941" checksum="89E1555EF50C6F12" modified="2011-04-05" version="1">MTPIPLSEVAQFVEENIGRFHERRLERLQNLKLKEVLKRKNPYLFKAKNIHVAHDLVKSLLDAFLSSQEETVFGEFLEQLAIFVCKRVYGGRKSSSEGIDLEFEKDGVVYLVSVKSGPNWGNSEQIKKMRLAFQKAIKTLRTNQPKINVQAVNGCCYGKEYRDHGDYIKMCGQEFWTFISGNERLYLDIIEPLGHRAKERNEAFQREYARIINLFTDEFSRDFCQDGIIDWEKLVAFNSEKKESEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB5</accession>
    <name>E8MYB5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558458.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62060">
        <property type="protein sequence ID" value="BAJ62060"/>
        <property type="gene ID" value="ANT_00260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00260"/>
    <dbReference type="HOGENOM" id="CLU_899080_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="34574" checksum="1E3D1160001CFEAD" modified="2011-04-05" version="1">MKPLHISPSGKWLFHATPQGNVMVWDLSGGTLHAVCDGLWIGHSLDEEHLLTQTPEGVKAWNLPRGEEEPLALLKAELFALHQRVVVRKQPYTLQLDLLDVLTGEMVLNLRFEQDPRYHPRLEACALAPDDRSLLITLAGEFGGQAWAHGYVLGVPGGARRVKFKVNRHQPPAFFAFTAQPFQVLLQDEMYHLTVLNLEQDRFEQDVWVSGFSGAAAFFPLLPAVLAVSVWEPIVDPAISPFSVQFLDLRRTSGERMRRAAVIAVFQESQPVHDMIFTPDGQTLAVLVSTGAIHLWNLAQGRIERTLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD1</accession>
    <name>E8MYD1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62076">
        <property type="protein sequence ID" value="BAJ62076"/>
        <property type="gene ID" value="ANT_00420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00420"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023978_1_1_0"/>
    <dbReference type="OMA" id="VICDNCT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="422" mass="48171" checksum="9C9FD17A9D3F3A92" modified="2011-04-05" version="1">MDALDARTLRAVFSFVLTLLQLPAMGVFLYFITLSAFAWVRRQEPNAAQFPLKHRFALVVPSHNEQLVIGKIVENLKALDYPADLYDIVVIADNCTDATAQAAREAGALVLERFDAIRKGKGYALEWVFPQLFQRTPAYDAVCIFDSDNLVSPNFLKEMNKHLCLGHKVVQGYLDSKNPLDTWISANNSIAFWIGNRMYQLPRSYLGLSNVLGGTGMMIASDVLKSIGWGATCLTEDLEFTVKVVLQGMKVHWAHDAVIYDEKPLGLRQSMRQRVRWMKGQADVISRFFIPLLKRFWTQRDWVALDLAVYILQPVFILVNFFCLIMGLILSAVFPQPVQSETNAVISQILFLLMLYMNGFFLFLEGRASPAVLGYFLTYPLYNLTWIPVVMVGFWKKNHKEWSHTLHTRVLDLREVPHVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF9</accession>
    <name>E8MYF9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="4">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_00700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00700"/>
    <dbReference type="KEGG" id="atm:ANT_00700"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_0"/>
    <dbReference type="OMA" id="WWPKDFT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0711">Selenium</keyword>
    <keyword evidence="11" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="36"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="11">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="233" mass="25608" checksum="25945420059CE9F0" modified="2011-04-05" version="1">MSEPEGCVKPSRGPLVEMSEQTETVVVPKEVPMIRAQVGKPAPDFELSALVGNGFKNIRLSDYKGKWIVLCFYPGDFTFVUPTELSAVAVKYPELQALGVEVLAISTDSRFSHKIWQEEELSKMVEGGVPFPLLSDAGGRVGSIYGVYDENAGVDIRGRFIIDPDFVIRAMEVLTPEVGRNVAELIRQVKAFQHVVATGEVTPSGWQPGKPTLKPGPELAGKVWKVWKPDMAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYG2</accession>
    <name>E8MYG2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558505.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00730"/>
    <dbReference type="EnsemblBacteria" id="BAJ62107">
        <property type="protein sequence ID" value="BAJ62107"/>
        <property type="gene ID" value="ANT_00730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00730"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_409202_0_0_0"/>
    <dbReference type="OrthoDB" id="773769at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="671" mass="74599" checksum="0E1F67D252C0794D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ5</accession>
    <name>E8MYJ5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_23050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560698.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64331">
        <property type="protein sequence ID" value="BAJ64331"/>
        <property type="gene ID" value="ANT_23050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23050"/>
    <dbReference type="eggNOG" id="COG1600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030790_0_0_0"/>
    <dbReference type="OMA" id="ICDTDLS"/>
    <dbReference type="OrthoDB" id="1478472at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013542">
        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="376" mass="42773" checksum="3FA597EAFF03A5D6" modified="2011-04-05" version="1">MSLETQIKQFFYERGANGVGITHLESPPHYPQYLQWVEAGLHGSMSYLDNERARALRGNPQAILPSARSVVFVSLPIASSIQSPPANRPLTGRVASYAWGEDYHLVFPKLFQAFVEWLSQQLGRVPEAKWYTDTGPVLERDLASRAGLGWIGKNTCLIHPRKGSFFLLGEIFLDVALEPDEPFKTDHCGTCTRCIEACPTECILPNRTLDASRCISYLTIENKGSIPRELREKMGNWVFGCDICQQVCPWNQRFGQTEPYPAFQPRENVPEPNLLEEIHLDSTGFNRKFKNSPVQRPRRRGYLRNVAVALGNAQDEYAVPALIECTENEPEPLVRQHAIWALGRYSSPRIREFFSQRLKEDNDEGVRLAIVQELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYL5</accession>
    <name>E8MYL5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AIRC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560718.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23250"/>
    <dbReference type="EnsemblBacteria" id="BAJ64351">
        <property type="protein sequence ID" value="BAJ64351"/>
        <property type="gene ID" value="ANT_23250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23250"/>
    <dbReference type="eggNOG" id="COG1691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_0"/>
    <dbReference type="OMA" id="EVIWGPG"/>
    <dbReference type="OrthoDB" id="1744359at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="120"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="27061" checksum="0AD9D244F563EF7D" modified="2011-04-05" version="1">MQEEMLRELLQAVQRGEMDINDAMQRLRLLPFESVGGFAHLDQHRAIRCGFPEVVFGQGKTPEQVVQIVRRLAERNDRVLVTRVAAEMAQVVLEQIPEMAYHAVPRLLILNRSPDTPKRPGIVVATGGTADIPVAEEAAMTAELMDQQVVRLYDVGVAGLHRLLGHLEVLQRARVIVVVAGMEGALASVVGGLVSAPVIAVPTSVGYGANFQGLSALLTMLNSCATGVSVVNIDNGFGAGYLAGLINRLGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM4</accession>
    <name>E8MYM4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ordered locus">ANT_23340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560726.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23340"/>
    <dbReference type="EnsemblBacteria" id="BAJ64360">
        <property type="protein sequence ID" value="BAJ64360"/>
        <property type="gene ID" value="ANT_23340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23340"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_0_0_0"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="130"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="339"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="477" mass="52149" checksum="050C87E462E1842E" modified="2011-04-05" version="1">MLTLTDVLEALTGKHIDMQKPLTFSEAAIDSRQVIPGSLFVALPGVRTDGHQFVGAAFQNGAILALVEKDLPQDFPTLDLRAVSPETPLAFPASWIPGQPLCLRVNNTLEALQQLARYWRRRLNIRVIGITGSVGKSTTKELIAEVLSQRYRTLKNPGNLNNEIGLPLTLLRLGKGHERAVLEMGFYVPGEIALLCDIAQPQVGVITNIGTVHAERAGSQEAIARGKSELVQALPVGGYAILNHDDPWVRWMADKTQAQILYYGLTPEAHLWADEIETMGLEGIRFRLHYRRESFSVRVPLIGHHSVQTALRATAVGIVEGLTWGEIIHGLQRSPTQLRLVAVRSSSGALILDDTYNASPESTLASLQILHEMKGRRIAVLGDMLELGPYEQSGHEKVGVRAAEVADVLVAVGELSKIIARAAREAGMKPEKIFWVPDTSQAIEVLRPLLKEGDVVLIKGSHGLRMDRIVSALEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM5</accession>
    <name>E8MYM5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mraY</name>
        <name evidence="8" type="ordered locus">ANT_23350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560727.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23350"/>
    <dbReference type="EnsemblBacteria" id="BAJ64361">
        <property type="protein sequence ID" value="BAJ64361"/>
        <property type="gene ID" value="ANT_23350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23350"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_1_0"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="330" mass="36055" checksum="CCBE8D410D29414C" modified="2011-04-05" version="1">MSDSTLAIALSMLSFMLTVIWGSPLLRILHHFRIGKIIRVEGPAHHMTKMGTPTMGGVLFILPVVLLTVLLNAASLLGLNVLGRSVLLPVLVLLSYGVLGAVDDWEGIRGPRRGLGMRARTKFLLQVVLAFIIAFALKYILEVPELYWPPLDEPISLGWLYIPIAMFLIVGASNAVNFTDGLDGLAGLISATAFAAYGAIALFQGQVFLARFCFTVVGALFGFLWFNVHPAQLYMGDTGSLPLGAVLAVVALMTGQWLLLPLIAIIPVSEAVSVIIQTTYFKITKGKRFFKMAPIHHHFELLGWSETQVVQRFWLVNLLFALLGIAFALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM7</accession>
    <name>E8MYM7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsW</name>
        <name evidence="7" type="ordered locus">ANT_23370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23370"/>
    <dbReference type="EnsemblBacteria" id="BAJ64363">
        <property type="protein sequence ID" value="BAJ64363"/>
        <property type="gene ID" value="ANT_23370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23370"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_0_1_0"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="415" mass="44769" checksum="EFB1FBE8566E4713" modified="2011-04-05" version="1">MGTGTFVNQPLQRSISRRFRAVRTGIDFVLVGVVIALVLFGLLMVYSAGPLFAALLKQNADFFLIRQSMWALLGFVGAGVLMFLDYHFYKRFTLLIMGGTIALLLAVIVIGDMTFGATRSLNEGSIRPSEFAKLATILYVAVWLNAKKDVLNDITFGLIPLILILGVVGALIMLQPDFSAAFTIVVLGAMLFFLAGGEWRQIALVLVITLFLGWVIVNLYPTGKDRVLGFWSGLQEPIKAEYQVRRSLEAIIRGGVFGVGIGNSTTKLTGLPVAHNDSIFAVIAEETGLVGAFLLIGAYVVFLWRGLAIAKNAPDELGSLLAGGITIWIVLEAMLNIGVSVNLLPQAGNALPFISYGGSSLLSTLAGVGILLNIGRLGNQQKQKGEQTLGAVVNLRWRDGRRRVSRPVHPASPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS8</accession>
    <name>E8MYS8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23880"/>
    <dbReference type="EnsemblBacteria" id="BAJ64414">
        <property type="protein sequence ID" value="BAJ64414"/>
        <property type="gene ID" value="ANT_23880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23880"/>
    <dbReference type="HOGENOM" id="CLU_2285558_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="101" mass="11819" checksum="FBB9378EEF7B8D74" modified="2011-04-05" version="1">MTMNVRGFIGSEAAKRRERMLDAVKKDCFQIQSRQFYRGEGKTITLWEVWSSHTHRRYPRLYVVSRVEAQGRIAFGCTCPDFESNGQWFPCKHILFVQQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYU8</accession>
    <name>E8MYU8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64434">
        <property type="protein sequence ID" value="BAJ64434"/>
        <property type="gene ID" value="ANT_24080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24080"/>
    <dbReference type="HOGENOM" id="CLU_3179509_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="46" mass="5341" checksum="1FFC86854101F4C9" modified="2011-04-05" version="1">MERDRRHDSGGDGMSEAVRFLVLGLSIGFALGYTFEVLRDFFMERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ35</accession>
    <name>E8MZ35_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558576.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01440"/>
    <dbReference type="EnsemblBacteria" id="BAJ62178">
        <property type="protein sequence ID" value="BAJ62178"/>
        <property type="gene ID" value="ANT_01440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01440"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_0"/>
    <dbReference type="OMA" id="AKDANTM"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="276" mass="29467" checksum="34881424BA5AC6E6" modified="2011-04-05" version="1">MSELHPYALFSLQERVAVITGGAGGLGSVMARVLARAGAQVIILNRTLEKAEHLAKAVRQEGGKALAMRCDVLRPEVLRTARQRIVETFGRVDILINAAGGNRPAATTAPDQSFFRLSPAAMKAVFDLNLFGTIYPCQVFGERMAEQGNGVILNITSMTALRPLTRVVAYSAAKAAVANFTAWLAVTMAREYSPAIRVNALAPGFFVTEQNRFLLVEDNGEPSPRGRDVLAHTPMGRFGEPEDLAGAVLFLVSDASRFVTGTVVTVDGGFSAFAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ55</accession>
    <name>E8MZ55_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558596.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01640"/>
    <dbReference type="EnsemblBacteria" id="BAJ62198">
        <property type="protein sequence ID" value="BAJ62198"/>
        <property type="gene ID" value="ANT_01640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01640"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090236_0_0_0"/>
    <dbReference type="OMA" id="AWIVADK"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="194" mass="21531" checksum="280E5C44ADF03A02" modified="2011-04-05" version="1">MPAFDHFDLLAPFYERFIHPRPPEDLLAHLHLPVDGALLDAGGGTGRVSQFLRDQARLVVVADLSCRMLAQARQKNGLCPVCSHTERLPFPDHAFARIIMVDALHHVCDQRATARELWRLLQPGGRLIIEEPDLRRFAVKLIALAEKLALMRSHFLAPPDIAALFDEPQAQVSVIAGTFNVWVVVEKPASPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA2</accession>
    <name>E8MZA2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62245">
        <property type="protein sequence ID" value="BAJ62245"/>
        <property type="gene ID" value="ANT_02110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02110"/>
    <dbReference type="HOGENOM" id="CLU_1192803_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="232" mass="26557" checksum="2CCEE82ED8A22205" modified="2011-04-05" version="1">MQKAHPKLLLLGWILLAIAVMFIYGDTVLRRSSQPFPHPTATLMPSETRVPPVESSGVTMRWLNAYPQWGDHYRVELCYTLPDQRDWLLSNPFRKTSPLLKISGQDLLPIEEGTMYWRQDAGSKVVERCSYLLFFVGQPASGEEFLTLQVRFLIAPQSGQPEVCQPIRDIQGQRGENLTMSCIPRKGFPAKLIERLPLFLLQNDAVLRRPMESIEWDTLEGEWTFTFPVAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH8</accession>
    <name>E8MZH8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560881.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25000"/>
    <dbReference type="EnsemblBacteria" id="BAJ64526">
        <property type="protein sequence ID" value="BAJ64526"/>
        <property type="gene ID" value="ANT_25000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25000"/>
    <dbReference type="HOGENOM" id="CLU_1648624_0_0_0"/>
    <dbReference type="OrthoDB" id="1615933at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="160" mass="18715" checksum="E8B4C721146225B6" modified="2011-04-05" version="1">MVSEKTQSQAFVNEALPELFHRNPDTFVRLLERDGTRLLRFYWEEAGKRVKPENLRDAFGLNYLTYQPNRRTTIYLITLPEPKSYGEAYFAALVYRPYRVLFLSSDVSGVYSLERIPSEAGSEDTLLVEWTKRLHRVEIRRGVPPEKNAFLQAVWNELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ8</accession>
    <name>E8MZJ8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560901.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64546">
        <property type="protein sequence ID" value="BAJ64546"/>
        <property type="gene ID" value="ANT_25200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25200"/>
    <dbReference type="HOGENOM" id="CLU_1544461_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="20146" checksum="51220F027A9FAD4F" modified="2011-04-05" version="1">MNAEFPTIQKLFDQTIALQKASEAFYSRLTALFTYYSSEIADFWKRFSEEDHQAAVFLETIRNRLPRERLEQIADPGIFHRVQKCLEDTLILTGKPIDNLEEAYRIALQLEGLENHAIYEFMVLNFAPQEITQPSGIAHLKTHERIHQLKQNLPEAFRTSASRRKINANKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX0</accession>
    <name>E8MZX0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fdhD</name>
        <name evidence="4" type="ordered locus">ANT_02710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02710"/>
    <dbReference type="EnsemblBacteria" id="BAJ62305">
        <property type="protein sequence ID" value="BAJ62305"/>
        <property type="gene ID" value="ANT_02710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02710"/>
    <dbReference type="eggNOG" id="COG1526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056887_4_1_0"/>
    <dbReference type="OMA" id="RYCAGAT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="286" mass="32109" checksum="296CD00A165BBC87" modified="2011-04-05" version="1">MAFLGEQNMAQTSRRVFYWQYQQGEWQALSGEVIAEQAVTLTVNGEEWITLMCTPHQLEALAVGFLYNEGLIQSLEEVAILQPCENEHNVDIWLTHALSKPRRWRRTSGCTGGMTQVDGEEDLRVPFWGQAQVEAEQIIQWMEELYRHQELYHTARGVHASALSDGERVVVQCEDIGRHNTLDKLSGWVLLNNFSGAQRIVLTTGRISSEMLQKSARLGAGMVVSRTSPTSASVALAERWGITLIGYARRNRLTVYTHLQRLKGAPVDLPLTSGIAFSPSENPPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N038</accession>
    <name>E8N038_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558770.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62373">
        <property type="protein sequence ID" value="BAJ62373"/>
        <property type="gene ID" value="ANT_03390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03390"/>
    <dbReference type="eggNOG" id="ENOG5031EHN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313995_0_0_0"/>
    <dbReference type="OMA" id="FKSGMAY"/>
    <dbReference type="OrthoDB" id="1328778at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021683">
        <property type="entry name" value="DUF3267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11667">
        <property type="entry name" value="DUF3267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="195" mass="21570" checksum="AB41BFC4C5C38080" modified="2011-04-05" version="1">MLPPVVSIPDLPPQYCQVEYWRITASRKRILQANLLALGLLPLWWLIAVGLMIALGYSKDSLIITIPRVLLASVITVLLHEGVHALAVRAFGGKPQFGVLWKALAFYTTVKGMAFKRWVFLVFLLAPLVVLSILFPLMAVFLRGEFWLSVAFLAFMINGASSAGDVFITAVLLRYPPTAYVADEIDGVRIFLPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N089</accession>
    <name>E8N089_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560992.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26120"/>
    <dbReference type="EnsemblBacteria" id="BAJ64638">
        <property type="protein sequence ID" value="BAJ64638"/>
        <property type="gene ID" value="ANT_26120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26120"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063649_0_0_0"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="215"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="394" mass="45584" checksum="B4938D182066FA3C" modified="2011-04-05" version="1">MNLPVSPDQKIVGDTLLIISHTPHYYHDGRYWGWAPTIRELDWLSSLFRRVIHVAPLYPGVPPKSALPYTSANITLASVTPSGGNSLGEKWRILKNYPAYFNVISRYLKIADAVHVRCPANISMLALLMLLFRKFPRRRWFKYAGTWMPQQKEPWSYSFQRWFLRTGLLRGVVTVNGSWFHQPAFIRSFYNPSFSEIELAEAQRMSSEKRLILPIQVLFVGRLEEAKGVDRALDIVQIFEKNRVPYTLHLVGDGEKRKWYEEKCEPAMIEKKVIFWGWLSPKELSSLYAKAHFVLLPSSSSEGWPKVLSEGMAFGAIPIASSVSCIPQYLQSFQVGAAIAVDDIQTYQQTLLEYIHLPDKWEQESARAREHARKFTYEYYLKKVRELFVEQDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H1</accession>
    <name>E8N0H1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26940"/>
    <dbReference type="EnsemblBacteria" id="BAJ64720">
        <property type="protein sequence ID" value="BAJ64720"/>
        <property type="gene ID" value="ANT_26940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26940"/>
    <dbReference type="HOGENOM" id="CLU_199499_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="77" mass="8412" checksum="8927909CC3EA387F" modified="2011-04-05" version="1">MDNQRWMTCSICGFRFSPEEHPGCAACPLHEGCQTVCCPNCGTSQINPERSSVARFIKKLITKKESHAPSSTPTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H2</accession>
    <name>E8N0H2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">feoA</name>
        <name evidence="3" type="ordered locus">ANT_26950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26950"/>
    <dbReference type="EnsemblBacteria" id="BAJ64721">
        <property type="protein sequence ID" value="BAJ64721"/>
        <property type="gene ID" value="ANT_26950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26950"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2731162_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="71" mass="7952" checksum="71BC9B23C9BE7B46" modified="2011-04-05" version="1">MFPGKRALIAGIGDLPDEQTHRLQAYGILPGRLVRVLSKRPMVIVQVEQTELALEESVARQIFIAQENNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L6</accession>
    <name>E8N0L6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561113.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64765">
        <property type="protein sequence ID" value="BAJ64765"/>
        <property type="gene ID" value="ANT_27390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27390"/>
    <dbReference type="eggNOG" id="ENOG50331NN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2766840_0_0_0"/>
    <dbReference type="OrthoDB" id="1900642at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="69" mass="7709" checksum="1C6D4EA1DDF89B31" modified="2011-04-05" version="1">MSVKSRGASNQQVSRAGEYFVVAELNKRGAFAVPFAGNMPKIDVIACNSDESRTVYIQVKTKRGWKTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U6</accession>
    <name>E8N0U6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558887.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04570"/>
    <dbReference type="EnsemblBacteria" id="BAJ62491">
        <property type="protein sequence ID" value="BAJ62491"/>
        <property type="gene ID" value="ANT_04570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04570"/>
    <dbReference type="eggNOG" id="ENOG502ZW25">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098984_0_0_0"/>
    <dbReference type="OMA" id="HVCPRQN"/>
    <dbReference type="OrthoDB" id="1271408at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021441">
        <property type="entry name" value="DUF3090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11290">
        <property type="entry name" value="DUF3090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03847">
        <property type="entry name" value="TIGR03847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="183" mass="20679" checksum="0D0DB63231C779E3" modified="2011-04-05" version="1">MPRFELDLNPVDHITTDAIGQPGKRVFYIQGVKDDQVVTLIVEKIQIQTLALGVEEFLQEIANRFPHLSAPAAEYDESKMHITPPVDPLFRVGELALAYDSDNDRVILIARELVAEEEMGEDPASMEERAGVVRFWCTRSQIRAMARWGLEVAARGRPLCPYCGEPMDPEGHFCPKRNGHKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V6</accession>
    <name>E8N0V6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="6">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thrC</name>
        <name evidence="6" type="ordered locus">ANT_04670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558897.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04670"/>
    <dbReference type="EnsemblBacteria" id="BAJ62501">
        <property type="protein sequence ID" value="BAJ62501"/>
        <property type="gene ID" value="ANT_04670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04670"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_0"/>
    <dbReference type="OMA" id="DDVNRFC"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="82"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="419" mass="44297" checksum="7E2B1478E8E8EB8B" modified="2011-04-05" version="1">MTRATFQGYRCSLCGAEFAPQDWLYTCPHDGGNLDVVLDTPAIRQQTSPRQISAQTEPSLWRYLPLLPVDDPGGQGTPLRTAGWTPLYSPPALKAQTSLHALWVKDEGKNPTASFKDRASAVVVARARQIGAEVVVTASTGNAGAALAGMAAAVGHRAVIFAPRTAPPAKIAQLLVFGAQVILVDGNYDNAFDLTVQAAQEFGWYCRNTGYNAFTAEGKKTAALEIFEQVILPNRLDRPLCVFVSVGDGNIISGIHKGFKDLYALGWLETMPRLFGVQSTGSAAVANAFFAGTEEITPVQAATLADSISVDLPRDGVRAVRAARQTGGAYVLVSDDAILQAIAALGKAGIFAEPAGATAYAGLLEALKSGQIQPDDPVVVINTGSGLKDVKSAMRAVTEAPVIEPNLNALKRLLEKNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0X7</accession>
    <name>E8N0X7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04880"/>
    <dbReference type="EnsemblBacteria" id="BAJ62522">
        <property type="protein sequence ID" value="BAJ62522"/>
        <property type="gene ID" value="ANT_04880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04880"/>
    <dbReference type="eggNOG" id="COG5433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3179506_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="46" mass="5294" checksum="1ED1BAC2A68565E1" modified="2011-04-05" version="1">MEQAMACINHLVLGILPGKLKFRYLPHARRYFAAHPAEALDFITRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z4</accession>
    <name>E8N0Z4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05050"/>
    <dbReference type="EnsemblBacteria" id="BAJ62539">
        <property type="protein sequence ID" value="BAJ62539"/>
        <property type="gene ID" value="ANT_05050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05050"/>
    <dbReference type="HOGENOM" id="CLU_777654_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="356" mass="39510" checksum="369A6E1BC0CDDBE4" modified="2011-04-05" version="1">MKFPCNNCLITNCNASAHMRIENLYIMILYLQRGEFTRRQGTGTTPHNRMSLNSNQGPFSYAYSTGGRRRVSPARPSSSPSSPNSSGNGHFYPPDDRSESSPPSSPPSSPPPPPDFFFQNAAWWNRFSDQFHNDPFFIWRILGLCIGLFVFFFPATVGAAIHLFDIFWGGVDPNLVSDSSFLWLFINDFVVREVVIGIILCAGLLFIMLATHDEPLLYPIFLLIGLLFVGVSSIFSVVVSSRCILDLSCDPSAYILSVALILVLGIAGSALPFAYRIGSTILFSGVFLISFAYSSAVWLVKLAGTPPYIIATPEILRATLLLFLNFVLVFLPAGLSWRPLMEQMSLNRRNPQREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N102</accession>
    <name>E8N102_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_05130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558943.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62547">
        <property type="protein sequence ID" value="BAJ62547"/>
        <property type="gene ID" value="ANT_05130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05130"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472251_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="577" mass="64470" checksum="37CA2E6271A6176A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F0</accession>
    <name>E8N1F0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561238.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64893">
        <property type="protein sequence ID" value="BAJ64893"/>
        <property type="gene ID" value="ANT_28670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28670"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_0"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="427" mass="47597" checksum="5021F61B1CB8C0B0" modified="2011-04-05" version="1">MTASSLPHVVIVGAGFGGLRAARRFSRLPVQVTLIDRQNYHLFQPLLYQVATAGVSAGEIAYPVRAVLRRQRNARFLLAEVTDLDLSNRRLLTTAGEVRYDVLILAMGGQTNFFGNATLARHALTLKTLQDAERIRDHVLRLFEHASRESNVEKRRAMLTFAVAGGGPSGVEMAGALSELIHGVLKRDFPGFDLSIARVILLEAADRLLPAMPPALQQATLQALHAKGVEVWLNAPVESYDGTLIRLKDGRQIPSRTLIWVTGIRAAGLAERIPAPRASNGRIRVQPTLQVPGYPEVFVIGDAAYLEDEHGNPLPMVAPVALQQADWAVANVQCLLEGKPLLPFRYRDPGMMATIGRNQAVARLGRFRLRGFLAWLMWVVVHIFQLIGFRNRLAVMLNWAWDYFLYDRALRLIEHPEEKPEERQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H0</accession>
    <name>E8N1H0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_05410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558971.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62575">
        <property type="protein sequence ID" value="BAJ62575"/>
        <property type="gene ID" value="ANT_05410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05410"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="OMA" id="RGCTQAL"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="333" mass="36632" checksum="64DF2D46868D4576" modified="2011-04-05" version="1">MPTIHQVAERAGVSSTTVSHVINNTRYVSPETRERVLRAMEELNYRPNVLARSLRRGETRTLGLILPDSANPFFAEVARALEFAAFRAGYNVIFGNSENDLEKEQVYVDVLVTKQVDGLIFMATGDRSQSLETLVRGGLPVVVVDRQLSALEVDTVLTDNLQGGLLATRYLIAGGHRRIGCITGPSHLTPSAQRVIGYRQALQEAGLEVDEALMVRGDFHPRSGYEAARRLLELRPLPTALFACNDMMAIGALRALAEAGLRVPEDFSIVGYDDIELASYAAPPLTTIRQDKVAIAESALRLALERIAQPELPARCETLPVELVERQSTRRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I8</accession>
    <name>E8N1I8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_05590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62593">
        <property type="protein sequence ID" value="BAJ62593"/>
        <property type="gene ID" value="ANT_05590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05590"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_32_0"/>
    <dbReference type="OMA" id="TSAFWAN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ANAPC4_WD40" evidence="3">
        <location>
            <begin position="259"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ANAPC4_WD40" evidence="3">
        <location>
            <begin position="580"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="663" mass="70982" checksum="8B09346730B25B12" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1L8</accession>
    <name>E8N1L8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="7">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">trpA</name>
        <name evidence="9" type="ordered locus">ANT_05890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559018.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05890"/>
    <dbReference type="EnsemblBacteria" id="BAJ62623">
        <property type="protein sequence ID" value="BAJ62623"/>
        <property type="gene ID" value="ANT_05890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05890"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_0"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="OrthoDB" id="912786at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="275" mass="29888" checksum="36ADCDC2D764C150" modified="2011-04-05" version="1">MSGIKRIAQIFEKARNQQRAALILYYPAGYPDYATSLEVLKGLAQSGADLLEVGMPFSDPLADGPTIQHATQMALSQRMNTRHCLALVRELRQQGVETPVVLMGYLNPVMAYGMERFVRDARQTGADGIILPDFPPEESADFRALCDAYELALISLVSPATPPERARQIAETTRGFLYLISLTGVTGARESLPPELEAFVARTRAVARVPLAVGFGISTPQQARRVSQIADGVIIGSALIARTGEAANPVQAAVEFIQQMFTALGKEELPRFESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M0</accession>
    <name>E8N1M0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">trpF</name>
        <name evidence="6" type="ordered locus">ANT_05910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559020.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05910"/>
    <dbReference type="EnsemblBacteria" id="BAJ62625">
        <property type="protein sequence ID" value="BAJ62625"/>
        <property type="gene ID" value="ANT_05910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05910"/>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_2_0_0"/>
    <dbReference type="OMA" id="FYAKSPR"/>
    <dbReference type="OrthoDB" id="1854712at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="215" mass="23248" checksum="9F6594C00B4256A5" modified="2011-04-05" version="1">MNIKICGLTTKEDALIAAEAGANFLGFVFYERSPRFIHPEGCARIVETLKGYPVQCVGVFVNHAVEKVQDILRTCGLALAQLSGDEPPAHLEQLAGKAFKALRPATPDELDENLHIYPPHHPAPAYLLDAHQPGAYGGTGLSANLEIARPLAMRMPILLAGGLTPENVAERVLRVRPWGVDVSSGVESAPGKKDPERIRAFIRAVRACEHALIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q4</accession>
    <name>E8N1Q4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_06250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559054.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62659">
        <property type="protein sequence ID" value="BAJ62659"/>
        <property type="gene ID" value="ANT_06250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06250"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125008_0_0_0"/>
    <dbReference type="OMA" id="CPCKETV"/>
    <dbReference type="OrthoDB" id="1619149at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="55"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="19273" checksum="813E7747E7ECDF95" modified="2011-04-05" version="1">MMWIGVGLFLFLLAVLMLIWAQHRLQAVGLPLGRIVSTDTSRWRALEKPLYDPETGLTGKPDYVVKVGGVLVPVEVKSAWAPAEPYDSHVYQLAAYCLLLARTSGKRPPYGFIHYRNRTFAVDFTPALEQALLGVIDEMHAEQRRSTVNRSHEESSRCARCGFRAVCDQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R6</accession>
    <name>E8N1R6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559066.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06370"/>
    <dbReference type="EnsemblBacteria" id="BAJ62671">
        <property type="protein sequence ID" value="BAJ62671"/>
        <property type="gene ID" value="ANT_06370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06370"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_0"/>
    <dbReference type="OMA" id="NIYISMP"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="42947" checksum="2AC24F6709D5D915" modified="2011-04-05" version="1">MRVLYFTRAYTPHDHRFLSALAESGQEVFYLPLENDGKALEDRPLPPQVERLHWQGGSGRFRWRDVPARVLELRRILRQVNPDVIHAGPVQTCAFVAALAGASPLVTMSWGSDLLKDAFSSGWMKWVTRFTLRASHVLVGDCLAVRDAAAGLGFPAEHVVLFPWGVNLERFHPVRESSPLRERLGWQDAFVVLSLRSWEPIYGVETVVDAFAQAFEEEPRLRLILLGQGSLAGRIQQRLHQRQLHEVVYLGGQVNQDDLPRFYQAADLYVSASHSDGSSVSLMEALASGLPVLVSDIPGNREWVTPGEAGWLFPVEDAHALAQGILRAVREPETLKDMRIRARRLAEERADWRKNFPKLLEAYRMALRRTGKLVEEKQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z5</accession>
    <name>E8N1Z5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561286.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29160"/>
    <dbReference type="EnsemblBacteria" id="BAJ64942">
        <property type="protein sequence ID" value="BAJ64942"/>
        <property type="gene ID" value="ANT_29160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29160"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_100_0_0"/>
    <dbReference type="OMA" id="LHKARML"/>
    <dbReference type="OrthoDB" id="1785082at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009594">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06719">
        <property type="entry name" value="AraC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="206"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="35993" checksum="E5C4DB62B317F3ED" modified="2011-04-05" version="1">MMDGHYQQEDREASRRKLAHQELVERILRALPEDGVIEPLKGLFLARVSTPRQRVHSVVKPSFCVIAQGRKEIWLGNSRYLYDPDHYLIATLELPRISQILEASPERPYLSFRLELDPALVYEVMLNAGQSVPSPRMDVRAMDVSPLDTDLLDAVVRLVRLLDAPDEAPALMPWITREIVFRLLKGAQGVRLRHLTTLNGYTPLIARAVERLRQDLNLPLRVEDLARELGMSVSGLHHHFKAVTSMSPQQFRKQLRLQEARRLMLSENLDAASTAYRLGYHDPAHFSREYKSLFGNSPVRDIQRLREETLNPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N209</accession>
    <name>E8N209_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561300.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64956">
        <property type="protein sequence ID" value="BAJ64956"/>
        <property type="gene ID" value="ANT_29300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29300"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016044_0_0_0"/>
    <dbReference type="OMA" id="DERMIFL"/>
    <dbReference type="OrthoDB" id="924064at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="568" mass="62176" checksum="CAED309EC067B6A3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8N210</accession>
    <name>E8N210_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64957">
        <property type="protein sequence ID" value="BAJ64957"/>
        <property type="gene ID" value="ANT_29310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29310"/>
    <dbReference type="eggNOG" id="ENOG502ZWTI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825491_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="336" mass="38535" checksum="9BD0E6FCB0401A86" modified="2011-04-05" version="1">MTMRRSSSFAVGVILLSLALALGYMYYLNIEKNTLDMRLDLHRQIVQGSAPSPYQYRVLVPFLAEGLFRVERLFFPDYRAFALSYIVLNVGALFLWLWAGFRLLRVWYRTEYALIGTLFVAAVTPLTFYDHYFQPWSFWEAFFYILSLMLMAEGRWGWLAGVVLLASLNRETAVLILPAFALTMLAGERLFNLRGWQWTRAGWLALYALLWGGVFLALRGLRPATQPVETLAQIWQFNIQPAHLFRAGVNWVLFLGGFWLMAFLAYRRAPLFLQRAGWVLVFHLPLILVWGYWQEVRMLLPHAFVFVGLGLAVFPEALKPSPPPSPSPAPETRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N228</accession>
    <name>E8N228_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561319.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29490"/>
    <dbReference type="EnsemblBacteria" id="BAJ64975">
        <property type="protein sequence ID" value="BAJ64975"/>
        <property type="gene ID" value="ANT_29490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29490"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_843703_0_0_0"/>
    <dbReference type="OrthoDB" id="2102970at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="34450" checksum="92B929CE026725CE" modified="2011-04-05" version="1">MNSDLSFREYERFSAYLDGQLSPQEVSRLEEDLRRNPQWQLALDELRETRALLRRAPRYRAPRNFTLTPEMVGKTARPGLFSFLSARFAASMAGLALMSALILQFLPALRFAAPMAAAPAPQAQQAPAMEFAPQATQAAPENQLRAAMEPTAIVPIILWHAPGGMGGGGGAPEGQGGEAMKAAGAPSGEGIVTYNQDTTAKGMGGGAGDGTEGYVPPGEGIVQYGGQPAPGTIPPVVPTEESVRALQSEATPAPAQPLEGSGPILGVPAPEEAGQVIALVPAPQESAREFAAPVQAVPSFWTSQRIAQVILLALAVLFGGLALRLRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N233</accession>
    <name>E8N233_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561324.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64980">
        <property type="protein sequence ID" value="BAJ64980"/>
        <property type="gene ID" value="ANT_29540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29540"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1248495_0_0_0"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="221" mass="23668" checksum="0CB392EF54309723" modified="2011-04-05" version="1">MTLPFRWIFTGIVLGASFLIFAANAIGQIQVVAASTEEPSFSAPVETLAPPGESTESAPSAESAPAESAPTAQEEAKSSGDGNCEVSPRFPEAVYRWCDLITRYANENGLDPDLVAALIVQESGGKPDAYSRSGAVGLMQVMPRDGIAASFRCVNGPCFASRPSMAELYDPEFNIRYGTRMLAGLISKRGSVRDGLMAYGPMNVGYSYADKVLAIYERFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N269</accession>
    <name>E8N269_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561360.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29900"/>
    <dbReference type="EnsemblBacteria" id="BAJ65016">
        <property type="protein sequence ID" value="BAJ65016"/>
        <property type="gene ID" value="ANT_29900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29900"/>
    <dbReference type="eggNOG" id="COG4012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803466_0_0_0"/>
    <dbReference type="OMA" id="LFEHHTR"/>
    <dbReference type="OrthoDB" id="1184211at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014846">
        <property type="entry name" value="DUF1786_pyruvate_format-lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08735">
        <property type="entry name" value="DUF1786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029129">
        <property type="entry name" value="DUF1786_pyruvate_format-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="378" mass="41566" checksum="4D2945DA3AEB164F" modified="2011-04-05" version="1">MKILAVDVGTGTQDILLFDSHLDVENALQLVLPSATMILRRRIQRATQRRSAIVLYGQIMGGGPCAWAVEDHLKAGLTVYATPSAAQTLNDDLEAVEDMGVRVITESDVYRLPEGVERIEMKDFDFGMLRRTLLSYEVSLDDLAAVAVAVFDHGAAPRGVSDRQFRFDYLDRRIRVENRLSAFAYPAQAVPPEMTRLQAVAEQAQMAGVPVVVMDTAPAAVLGALFDPQVSRWEHALVVNVGNFHTLAFRFGERRRIEGVFEHHTGFLTPEKLDAYLTALAQGTLTHEEVFSDMGHGALVYHSNDTGELPPVAVTGPRRSLMRASTLRPYFATPFGDMMMSGCFGLLAAVADHLPNLREEILERLHAAPSGAAPWDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N276</accession>
    <name>E8N276_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561367.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29970"/>
    <dbReference type="EnsemblBacteria" id="BAJ65023">
        <property type="protein sequence ID" value="BAJ65023"/>
        <property type="gene ID" value="ANT_29970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29970"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609229_0_0_0"/>
    <dbReference type="OMA" id="HPIYILT"/>
    <dbReference type="OrthoDB" id="514488at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="449" mass="51930" checksum="FCB813FAC2C75A8D" modified="2011-04-05" version="1">MTLQATPEDLFTLLRAEREGAWLGRVFVSPEGVERVRGMQSVILVGADGVGKTALMEYLKGQSLHNPAGPLMVWWRPVPLPAPDALQSVNGFREQAFQETSIAALDWAGRFPHLVKQAPQYAQRSWVACVDAFIPPFQQERLLYEYPVLRELLSDLRARVDQTFSALFSIPSLDVLRAWVDALRAMGCLGVWVVVDGLEMWQSPESDALLVQMKHLLSSMVWFEQAGFALKILAPERFQKVLLSAIKPENKRIQPAMLIWSVEKLKEIVECRLHWITGKPEPTLETLVQDGFLLTVLKQYGGMLPRGWLDLTYPFVKAYLEKKSPLTMAEGEQILRKYPPRLRLDLQRKRVILGYSVWEVSPQSYDLLEYLYRQPDFSCTKEELYYRGIRRYENIPAPGSKEWEPPSDWWGVMDTALWRLRREIERDPGNPLYILSERRKGMVRLNWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N292</accession>
    <name>E8N292_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561380.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30130"/>
    <dbReference type="EnsemblBacteria" id="BAJ65039">
        <property type="protein sequence ID" value="BAJ65039"/>
        <property type="gene ID" value="ANT_30130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30130"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766486_0_0_0"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="220"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="358" mass="40998" checksum="468D974637FE5383" modified="2011-04-05" version="1">MTDTLFASDLAHLSRREFLRWLGRGALGLFALPFLDPYTRRERLNHPPDGPAVSRVRCVDDHVAVYDRPSFSAALRQVYWRDLVFEVDEVVIGDEQPAHNRVWYHLKGKGFAHSGKLQPVEVRLNPPAASVPPTGWLAEVTVPYTDTLRDLNRPDRPGYRLYYSTVHWVQKVLKDGEGAVWYQLWDDKFKRVYYARAEHLHLLKPEEIAPLAETVPPEAKRIEVWLKDQLVIAYENDEPVLITRAATGGKFIDGDYSTPQGRYLTNRKRPSRHMASGDLAAPNSYDLPGVPWVCYLTESGISFHGTYWHNDFGKPRSHGCINLSPAAARWIYRWTHPAVPFDQVTWWEDTGTSVVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2E3</accession>
    <name>E8N2E3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein EutN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eutN</name>
        <name evidence="1" type="ordered locus">ANT_07150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559142.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62749">
        <property type="protein sequence ID" value="BAJ62749"/>
        <property type="gene ID" value="ANT_07150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07150"/>
    <dbReference type="eggNOG" id="COG4576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148498_0_1_0"/>
    <dbReference type="OMA" id="GAGINEW"/>
    <dbReference type="OrthoDB" id="1832681at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01614">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004992">
        <property type="entry name" value="EutN_CcmL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036677">
        <property type="entry name" value="EutN_CcmL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36539">
        <property type="entry name" value="PTHR36539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03319">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159133">
        <property type="entry name" value="SSF159133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51932">
        <property type="entry name" value="BMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="96" mass="10039" checksum="631B33DF6B822B64" modified="2011-04-05" version="1">MQIARIIGSAVSTAKDPKLTGFKLLVAQRATPDNQVYGDPFLVADTVGAGEGELVILVEGSSARETLKTANIPVDAVVIGILDSIEVNGELVFQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H9</accession>
    <name>E8N2H9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocating P-type ATPase</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_07510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559178.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62785">
        <property type="protein sequence ID" value="BAJ62785"/>
        <property type="gene ID" value="ANT_07510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07510"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_4_0"/>
    <dbReference type="OMA" id="FAQPWET"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="730" mass="77975" checksum="271646AC5D2DC188" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I3</accession>
    <name>E8N2I3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_07550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07550"/>
    <dbReference type="EnsemblBacteria" id="BAJ62789">
        <property type="protein sequence ID" value="BAJ62789"/>
        <property type="gene ID" value="ANT_07550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07550"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514875_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="entry name" value="PTHR46313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="177" mass="20043" checksum="73E0E774913D8FF3" modified="2011-04-05" version="1">MNSVTALWGGDIEFGAKVEKIFVEDGKAVGVRLVDGIERHADIVISAADGYSTLFHMLGDAYVDETFRRYYRELKTFPALILVGVGIKRTFEQEPQSVLGINYVLQPRLKIGEKERRRIGVHPYHHDPTMAPPGKTTLIVILDSDYDYWKALAEDPQAYEKEKEAVKHGVIQALEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N0</accession>
    <name>E8N2N0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_08020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559228.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08020"/>
    <dbReference type="EnsemblBacteria" id="BAJ62836">
        <property type="protein sequence ID" value="BAJ62836"/>
        <property type="gene ID" value="ANT_08020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08020"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400987_0_0_0"/>
    <dbReference type="OMA" id="MWASIEN"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="5">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42" evidence="5">
        <location>
            <begin position="107"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="6">
        <location>
            <begin position="381"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="686" mass="77414" checksum="AFCFC3FE6AE77216" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S2</accession>
    <name>E8N2S2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561413.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30460"/>
    <dbReference type="EnsemblBacteria" id="BAJ65072">
        <property type="protein sequence ID" value="BAJ65072"/>
        <property type="gene ID" value="ANT_30460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30460"/>
    <dbReference type="HOGENOM" id="CLU_112459_0_0_0"/>
    <dbReference type="OrthoDB" id="2016484at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="204" mass="22595" checksum="B661878CDC7F08EE" modified="2011-04-05" version="1">MTMNTAFGRLLGASTLESLVGCRVTQANVPAFGTLARLPVDDTYQVYGLVYNIHIEEDGTVRQLAAAGDIRDEVVRDNRENRTVPIEFNLLHVGYEENGRISHLLPPRIPLSLEVIHACTPAEVVRFTGAGRLGYFRHILRAEQAPIPELFAAHLLQASRAHAQMGDPHWLQRAQQEIIILLRDDYAALMNVLNALADVAQTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T3</accession>
    <name>E8N2T3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ycf81 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561424.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30570"/>
    <dbReference type="EnsemblBacteria" id="BAJ65083">
        <property type="protein sequence ID" value="BAJ65083"/>
        <property type="gene ID" value="ANT_30570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30570"/>
    <dbReference type="eggNOG" id="COG4956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050839_0_0_0"/>
    <dbReference type="OMA" id="TMPTDLL"/>
    <dbReference type="OrthoDB" id="940436at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="291"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="360" mass="39376" checksum="DA850092D1F8849E" modified="2011-04-05" version="1">MSADFVARLIGMIVFSILGVYLGTHLGRLANETPSEFVFSVEQYAFTIGMVGALIGLILTPYLTTRPIKSLRMQLSRLSTRSLLASLIGLIVGLIIAALLSFPLSLLPAPFGQVMPFIGVLIMAYLGVSVFLTRQDDLFSMVQGFSRGGAAGAEGGAPMAERTILLDTSVIIDGRIADIARTGFLPGSLLIPRFVLNELQYIADSSDTLRRQRGRRGMEVLAQLQKEPGIPVRITDLDVEGVREVDDKLVILARQLRCPILTNDYNLNRIAELQGVTILNINELANAVKSVLLPGEMLQVRIIQEGKEPSQGVAYMDDGTMVVVENGRDYMDQEINVVVTKVLQTAAGRMIFARPERENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W9</accession>
    <name>E8N2W9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561460.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30930"/>
    <dbReference type="EnsemblBacteria" id="BAJ65119">
        <property type="protein sequence ID" value="BAJ65119"/>
        <property type="gene ID" value="ANT_30930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30930"/>
    <dbReference type="eggNOG" id="COG3695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_0"/>
    <dbReference type="OMA" id="HRHEQSA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="15305" checksum="D2D9E1ECF29E3780" modified="2011-04-05" version="1">MSPASLPRAAEPAFYAAVWLLAKQIPPGKVFPYGRIAACIPCPEGLSPDLYRVQRARWAGQAMAVCPDDVPWHRVPAADGRLIIVARSREEQRRRLEAEGVTFDARGRVRMSLHLWEGPDPQWLESHGFLPQPNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N329</accession>
    <name>E8N329_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ordered locus">ANT_31550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561519.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31550"/>
    <dbReference type="EnsemblBacteria" id="BAJ65179">
        <property type="protein sequence ID" value="BAJ65179"/>
        <property type="gene ID" value="ANT_31550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31550"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_5_2_0"/>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="19237" checksum="468EF5CE01529CF8" modified="2011-04-05" version="1">MAVRTIVTVPDPVLRRKAKKVTTFDKDLQVLIDDMIETMRAAPGVGLAAPQVGVSQRVIVVEYGEGEEEDENVPKKLYAVVNPEIVEASPERVTGVEGCLSIPRMMGEVERHERIVVKGLNRYGKPVKYKLSGWTARIFQHEIDHLEGILYTDRATSVWIPKEEEEVQDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N334</accession>
    <name>E8N334_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561524.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31600"/>
    <dbReference type="EnsemblBacteria" id="BAJ65184">
        <property type="protein sequence ID" value="BAJ65184"/>
        <property type="gene ID" value="ANT_31600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31600"/>
    <dbReference type="eggNOG" id="ENOG502ZB4E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036670_0_0_0"/>
    <dbReference type="OMA" id="PYRWYEY"/>
    <dbReference type="OrthoDB" id="1065636at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041113">
        <property type="entry name" value="Heliorhodopsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18761">
        <property type="entry name" value="Heliorhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="266" mass="30201" checksum="27B98807C2CBFAD7" modified="2011-04-05" version="1">METSSVQQSAPAKPVTFAGLRRFNLIMGFLHLIQGIFMWVVSNDRTYPIFTNYLTFDRTTFSLKPNPQLLYELPFGPAVALFLLISAVAHFYLSTIGYNRYVENLKKGKNPIRFYEYALSSSLMVVLIGMLVGIWDLGTLIVIFGINAMMNLFGILMEEHNQYTAKTDWMAFIYGSLAGIVPWIVIFLYFVGAVNSGDAKPPAFVYAIVPTLFVMFNIFAVNMVLQYKKVGKWRDYLFGERVYIVLSLVAKTVLAWLIWFGTLAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N388</accession>
    <name>E8N388_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_08680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559294.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08680"/>
    <dbReference type="EnsemblBacteria" id="BAJ62902">
        <property type="protein sequence ID" value="BAJ62902"/>
        <property type="gene ID" value="ANT_08680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08680"/>
    <dbReference type="eggNOG" id="COG2847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100939_1_2_0"/>
    <dbReference type="OMA" id="LHIMLFD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007410">
        <property type="entry name" value="PCuAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36302">
        <property type="entry name" value="PTHR36302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04314">
        <property type="entry name" value="PCuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="147" mass="16031" checksum="1B00F158EDE39565" modified="2011-04-05" version="1">MMKIAHRIGLGLFLSVILLMSACASRQSNLTIQDPWARLGVAGGNSAIYLKIENATKEDDALISASCDAAMMTELHMTQMMDDGTMKMEPQEKISIPAGQTVELKPGGLHIMLMNLKKDLKTGDTLNLKLKFEKSGEIEVSVPVKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A8</accession>
    <name>E8N3A8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-galactoside ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_08880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559314.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08880"/>
    <dbReference type="EnsemblBacteria" id="BAJ62922">
        <property type="protein sequence ID" value="BAJ62922"/>
        <property type="gene ID" value="ANT_08880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08880"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="LDPINTI"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="13"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="37599" checksum="B5597126F606EE49" modified="2011-04-05" version="1">MNVTTSTDSLPLLEIKDLRTYFFLEKGTVRAVDGVNLTLQRKTTLGLVGESGCGKSITAMSIMRLIQEPPGKIVSGEILLRSRTFGQVLDLVKIDRHSQTMRAIRGGEIAMVFQEPMTSLNPLYTIGDQIAETVQLHQKVSKKEALERALEMLVKVQIAMPKQRLKEYPHQLSGGMRQRVMIAMALSCNPSILIADEPTTALDVTVQAQILDLMRQLQEDIDSSIIMITHNLGVVSQMAHFVAVMYLGKVVEYGKTHDIFHRSLHPYTVGLLNSVPVLGRKGKKILVPIEGIVPSPMNIPPGCPFASRCPKVMSKCREVAPELQEKESGHWVSCWLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C0</accession>
    <name>E8N3C0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alpha-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_09000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559326.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09000"/>
    <dbReference type="EnsemblBacteria" id="BAJ62934">
        <property type="protein sequence ID" value="BAJ62934"/>
        <property type="gene ID" value="ANT_09000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09000"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="OMA" id="LECDWET"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="195"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="424" mass="47541" checksum="8FEA8A0E5A356284" modified="2011-04-05" version="1">MNTTKIVFIGAGSMSFGLSMFRDLFSTQELKGSELVLVDIDPEYLERMYRLALLMNERSGAGLRISRTLNRREALPGAGFVVNSIALERTRLWKLDFEIPKKYGVRHTLGENGGPGGLFFTLRTIPIIMDIIRDMEELCPNALFINFSNPESRIIYALGKYSRIQAIGLCHGVFMGRDDVARIMGLPAEEVDVWAAGLNHFQWFLQIRRRQTGEDLYPLLREKEKTFDPAFMPLSRRLFRAFGLYPSCSDDHIGEYLAYGWEAGEEGYDFDDDERYRVWLKTTIDGVLSGAEPPADFFQPSGERGVAVITGILHNQKRWIESGVVYNRGAIHNLPEDCAVEVPVVVDAHGVHPCTVGNLPAGIAALCSVQAHIQQLSVEAAMRGSKELALQALLIDPVIHSAKAAEQILDELWQINRPYIRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C7</accession>
    <name>E8N3C7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559333.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09070"/>
    <dbReference type="EnsemblBacteria" id="BAJ62941">
        <property type="protein sequence ID" value="BAJ62941"/>
        <property type="gene ID" value="ANT_09070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09070"/>
    <dbReference type="eggNOG" id="ENOG502ZIX3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1782853_0_0_0"/>
    <dbReference type="OrthoDB" id="169533at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="145" mass="15411" checksum="21FFB0A523761ED0" modified="2011-04-05" version="1">MPQEQSPSLETYRKGLPVEKKSNSSTGRKRFRSLLVGMAVIIIILAAINFFQSPAAKTLAGTGSVQGIVVNKDGKPLNAEIFITGTKWQTSTNADGQFSLTLPAGNYSLVVARNGMGNEYPISVQRGKTQDLGTIVLVSTPSPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3D3</accession>
    <name>E8N3D3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559339.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62947">
        <property type="protein sequence ID" value="BAJ62947"/>
        <property type="gene ID" value="ANT_09130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09130"/>
    <dbReference type="eggNOG" id="ENOG5032C76">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684502_0_0_0"/>
    <dbReference type="OMA" id="PWIARHL"/>
    <dbReference type="OrthoDB" id="1253790at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041273">
        <property type="entry name" value="DUF5596"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041644">
        <property type="entry name" value="GNAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18164">
        <property type="entry name" value="GNAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18082">
        <property type="entry name" value="NAT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAT_N" evidence="1">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GNAT_C" evidence="2">
        <location>
            <begin position="154"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="402" mass="46936" checksum="B885396ED0BBF863" modified="2011-04-05" version="1">MMKRIEETLSEEDWWNAKNRLVWWQFLGLSEGAVQALEDMAHQIQRSSNLMESFLALHEQTAHRGEWHFDWSPLSFNPVIEAQLGDGTSLFYLLVYLNALPHTLQAYQRRGISMDTFAETMADIPFYIEWYAQKYGRWGFEHFPWIARHLSGRLISLGRLQFMLLPFPGKVLALRHRFHHQVILLADPDQPLRADGYAVGAGNPDLPVPTEEVWYPQRQENEDGWMGHPISPQGYALKVPAFFTRDTWEIALQHGDWVLDVHIPRGKNLNLEECRDSLQRAFAFFPGHFPENPFRGVYCHTWMFTPQLQHLLRPDSHILQFQREFYLYPHPGSAGFLLEFVFGSREYPGNDAPRDTSLRRAVLDWLSHGHELFDLPGVFLSSPQEWGEQTHRKGWLAFVTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H2</accession>
    <name>E8N3H2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559377.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62986">
        <property type="protein sequence ID" value="BAJ62986"/>
        <property type="gene ID" value="ANT_09520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09520"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080433_0_0_0"/>
    <dbReference type="OMA" id="ARCCVNI"/>
    <dbReference type="OrthoDB" id="1169054at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="277" mass="31645" checksum="0DC49F46C3F438CE" modified="2011-04-05" version="1">MRLGGPLFQPYHSPEEWVTLVQRYGYRAAYCPVGIDAPHEVIRAFKHATRQAHLIIAEVGAWSNPLSSNQEERQEALKLCKQALALADEIGALCAVNIAGSRGEKWDAPDPRNLTPETFEMIVATVREILDSVKPRRAFYTLEPMPWMYPDSVDHYLDLIRAIDRPMFGVHLDPVNLINSPQRYFENSRLLKDCFERLGPWVKSCHAKDILLRPQLTTHLDEVRPGLGGLDYRTFLREASRLPQDVPLMLEHMTEEQDYLLAAQYLRQVAAEEGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H7</accession>
    <name>E8N3H7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559382.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09570"/>
    <dbReference type="EnsemblBacteria" id="BAJ62991">
        <property type="protein sequence ID" value="BAJ62991"/>
        <property type="gene ID" value="ANT_09570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09570"/>
    <dbReference type="eggNOG" id="ENOG50336PT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078700_0_0_0"/>
    <dbReference type="OMA" id="THIRRLT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="2">
        <location>
            <begin position="212"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="294" mass="33021" checksum="36B633BBD47C24C5" modified="2011-04-05" version="1">MKRFTVRQTLLFLVGGLLVLSLVLSAGLTGLELSPGLIYGNQRWQTAEDFTGSLPDATSLLGFFQVVLGLALALFPFYFVYMLLHPQRRKKLLRYLAIFAVMLFLFERLRQAMNNLNPENFGFQGGEFGTGEEVLPMPPLADFVANPPTWLINGVAVFTVILIALALFGMIWWFVMRRERQPHPLSQVGFEASQALASLQAGADLRETIIECYRRMVRAVAESRGVQRGNAVTPHEFIQTLVQHGLPERPVRRLTELFEDARYGHLSSTPRQQMEATGCLEEIVAACQSMETTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I6</accession>
    <name>E8N3I6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bidirectional hydrogenase H subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hoxH</name>
        <name evidence="5" type="ordered locus">ANT_09660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559391.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63000">
        <property type="protein sequence ID" value="BAJ63000"/>
        <property type="gene ID" value="ANT_09660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09660"/>
    <dbReference type="eggNOG" id="COG3259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044556_0_0_0"/>
    <dbReference type="OrthoDB" id="1967820at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="474" mass="52915" checksum="B6193476AD1ABBF0" modified="2011-04-05" version="1">MVAQKITIEPVTRIEGHAKVTIHLDEAGKVRRAYMHVNEFRGFEKFCEGRMVFEMPYITPRICGICPVSHHLAASKAADIVLGCPPPRPASLLRELMHMGQIVQSHGMHFFELAGPDLLLGFDADPAIRNVIGVAQMNTELAVRAVQLRKWGQSIIAILGGKRVHPNFSVPGGVNKALSPAERDEILAGLDESIATIQTGIQIIRDWAEANMEDIRKFAVFPTGYLGLITPENGLELYDGEIRLIGQDGVQLERFSAQHYLDYIAEHVESWSYLKFPYYKKLGWPNGVYRVGPLGRLNIAEKIDTPLANQEFKRFKALNPGKPVENTLYYHYARMIECLFAAERVRFLLDDPDILSTDILNTRKEVKGEGVGVIEAPRGTLLHHYWTDQNGQIKKVNLIVSTGHNNWAMSEAVDQVAKTYITGPVTEGMLNRVEAAIRAYDPCLSCSTHAIGQMPIVLDVVDAEGNVVQTLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I9</accession>
    <name>E8N3I9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">ANT_09690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63003">
        <property type="protein sequence ID" value="BAJ63003"/>
        <property type="gene ID" value="ANT_09690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09690"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_0"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="354" mass="38240" checksum="0526CC9BB550CB44" modified="2011-04-05" version="1">MAFDPFRWLLGLFSLDIGIDLGTANTLVHVRGKGIVINEPSWVTIEKPTRRPLEVGLRAKEMVGRTPANVIAVRPLRDGVVSEFEITRAMLEYFISKAHQQSIVPAPSPRVVIGIPSGATEVERRAVLDAASAAGAREVYLVEEPRAAALGAGLPVSEVRGTMIVDIGGGTTEVAIISMGEIVVSRSLRVAGDELDQDIIQYIRNKYNLFIGERMAEQVKIQIGSAYPLPQEKTMVVRGRNLISGLPESLEVSSVEIREAISGSLQVIVDTIKDALDEAPPEIVADLIETGVCLAGGGALLQGLSEWLSEELGLRVWVAEDPMTCVARGAGIVLENLDRYRNYLAPVERNGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K0</accession>
    <name>E8N3K0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_09800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559405.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09800"/>
    <dbReference type="EnsemblBacteria" id="BAJ63014">
        <property type="protein sequence ID" value="BAJ63014"/>
        <property type="gene ID" value="ANT_09800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09800"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_0"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="34802" checksum="D230562F864441FE" modified="2011-04-05" version="1">MQDQVFVFTCEPHQEGRLDKFLVAHFPELSRSQIQGLIRDGFVRVSGKTVQKTGFLVEAGKEVEIRIPPPQPTSLEPEPIPLEVIFENQDLLLVNKPAGMVVHPSAGHDRGTLVHAALAHIPELEGIHGEERPGVVHRLDKDTSGLILLAKNDRAHRWLQDQFRLRKVQKTYLALVDGRPPTPTGRIEAPIGRDPKNRQRMAVVPPEKGREAVSEYFTREVFPSHTLLEVHPLTGRTHQIRVHLAFIGCPVAGDLIYGHKHATVSLNRHFLHAYRLTIQLPGESSPRTFEAPLPSELEQVLQVLRGRTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M0</accession>
    <name>E8N3M0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsG</name>
        <name evidence="10" type="ordered locus">ANT_10000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559425.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63034">
        <property type="protein sequence ID" value="BAJ63034"/>
        <property type="gene ID" value="ANT_10000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10000"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_0"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="155" mass="17794" checksum="A285F24A52867FD2" modified="2011-04-05" version="1">MRRTKPEVREINPDVRYNSVLVQEFINRVMRRGKKSLAARLVYDAFDMVQEKTGRPAVDIFEQAIKNVGPIMEVRPRRVGGATYQVPLEVPARRRMTLAMRWIIQAAKARTGKSFSEKLAAELLDANNNQGAAVRKREETHKMAEANRAFSHFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3T2</accession>
    <name>E8N3T2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_10620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559486.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10620"/>
    <dbReference type="EnsemblBacteria" id="BAJ63096">
        <property type="protein sequence ID" value="BAJ63096"/>
        <property type="gene ID" value="ANT_10620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10620"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_5_0_0"/>
    <dbReference type="OMA" id="ILCHTTA"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="322"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="384"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="892" mass="100389" checksum="AB9E4D9C9AFDF8EB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3T7</accession>
    <name>E8N3T7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559491.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63101">
        <property type="protein sequence ID" value="BAJ63101"/>
        <property type="gene ID" value="ANT_10670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10670"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_8_4_0"/>
    <dbReference type="OMA" id="CIASCAY"/>
    <dbReference type="OrthoDB" id="616258at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="PTHR10887:SF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_12" evidence="1">
        <location>
            <begin position="350"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="579" mass="65234" checksum="CC86B4B736FE1C3E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X8</accession>
    <name>E8N3X8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="8">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_11080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11080"/>
    <dbReference type="EnsemblBacteria" id="BAJ63142">
        <property type="protein sequence ID" value="BAJ63142"/>
        <property type="gene ID" value="ANT_11080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11080"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_0_1_0"/>
    <dbReference type="OMA" id="NEHASHI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="199"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="431" mass="48394" checksum="38CCB51930BE23F3" modified="2011-04-05" version="1">MMKIAVIGGGSTYTPELIKGFLEVQDSLALDELMLMDIQPQRLEIVGDFCQRIAEHQGARFKVTLTDSRKEAIRGSAYVLTQFRVGYIPARREDEYLGKRYGLIGQETTGIGGMAKALRTIPVLLDIAREMQELAPEAMLVNFTNPSGLVTEALTRYAPDIPSVGLCNSPITTKMTLLNRWNALTGEQVSPEEVILDSLGLNHLTWYRGLTIRGQDRWDEVLHFYIEELRKSDHPEWPPQLIEALGMLPNYYLQYYYNTRAMLAAQDKWPPSRAEQVLKIEAQLLEEYANPNLVTVPEGLMQRGGAYYSTLATRVIHAHACSTGMIETVNVRQNGAVKEYPADWVMELPCRIDATGIHPLPARPLPEACYGLLAPVKMYELLTVEAAVHGDRKALYEALLVHPLGPDVSMIQTVMDDLLLTNRAYLPQFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N465</accession>
    <name>E8N465_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylenetetrahydrofolate reductase (NAD(P)H)</fullName>
            <ecNumber evidence="5">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ANT_11950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11950"/>
    <dbReference type="EnsemblBacteria" id="BAJ63229">
        <property type="protein sequence ID" value="BAJ63229"/>
        <property type="gene ID" value="ANT_11950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11950"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453272_0_0_0"/>
    <dbReference type="OMA" id="TNTYAAN"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="12">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="628" mass="68092" checksum="1739AD82CFE5248F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N472</accession>
    <name>E8N472_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_12020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559624.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12020"/>
    <dbReference type="EnsemblBacteria" id="BAJ63236">
        <property type="protein sequence ID" value="BAJ63236"/>
        <property type="gene ID" value="ANT_12020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12020"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="TWMYRIV"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="210" mass="24249" checksum="A31A850C6A8E6A62" modified="2011-04-05" version="1">MNEPNVKKPLSIQALKAGNREEFARMVEQYSPGIYRLALKMLGNGLDAEDVLQETFLKALRALPNFEERSSLSTWLYRIAMNEALMLLRKKRPEAFSLEDSTTNQEDGESIEEPRDIVDWCCLPENELLSSEAREFLNRAIERLSPALRAVFVLRDLQDLSVRETAETLGITETAVKTRLLRARLKLREELSAYYGHRMEVLGYDRIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N478</accession>
    <name>E8N478_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12080"/>
    <dbReference type="EnsemblBacteria" id="BAJ63242">
        <property type="protein sequence ID" value="BAJ63242"/>
        <property type="gene ID" value="ANT_12080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12080"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536026_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="498" mass="54767" checksum="E981D2DD53228DC0" modified="2011-04-05" version="1">MRKVWKRFLRAGILVGWISTMLISACVPLESSSAQSLFEPSNPQGKSLIEIQDTPTPMPARPIYQPGELVDYTAQTGDTLPAIAAHFNTSVKEILEANPFIPADATTMPPGMPMKIPIYYQPLWGSPYQILPDSHFVNGPALIGFDTQKFVLLQPGWLRFYNEYVGDRQRNGAEIVEYVATNYSISPRVLLAILEYQLGALTQPKMPGGLDEYPLGERDISYRGLYRQLAWTANFLNQQYYTWRKGRLEITLPDGQLERPDPWQNAATVALQVYFAGRLNMEGYRIAVSSEGFARTYRELFGEPWTTDPHIPGSLRQPELRLPFGAGKSWAFTGGPHTAWGEGEPLAALDFAPPSVVGGCSPTEEFATAVAGGKIVRTGTGIAVLDLDGDGDERTGWVIFYLHLASDGMAPLGSELQAGDPIGKPSCEGGRATGTHVHIARKFNGEWIPADGVIPFNLEGWIARNGASPYEGWLTRQNRSVKACVCSDQASQIQSQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G4</accession>
    <name>E8N4G4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxy-terminal-processing protease</fullName>
            <ecNumber evidence="6">3.4.21.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctpA</name>
        <name evidence="6" type="ordered locus">ANT_12940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.102" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559716.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12940"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="BAJ63328">
        <property type="protein sequence ID" value="BAJ63328"/>
        <property type="gene ID" value="ANT_12940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12940"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_3_2_0"/>
    <dbReference type="OMA" id="TFNQVDW"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="116"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="414" mass="44751" checksum="A599CC8920341B0B" modified="2011-04-05" version="1">MNKSIRYFVLGFIALILLAGAFSGGIVVGWLLPNRSASTTPTGPFISSASTTGGTPEDLQTLFKPFWEAWNIVNDQYVEQPVNQEKLMRGAISGMLQSLGDPHTSYMDPDQYRQANMPMSGEYEGIGAWVDITGAYVKIISPMPNSPAEKAGLKAGDIILKVNGEDMTGIDGNLVLRRILGPAGTQVTLTVQREGESEPLEFTIIRAKITIPSVESKMLDDGIGYIRLFTFGEKTTDELKNALKEILKQNPKGLVLDLRNNGGGYLTTAIEVVSQFIDKGVVMYEQYGDGREKSFNAIPGGLATKIPLVVLINEGTASASEITAGAIQDYQRGILVGTTSFGKGSVQNWVALDNDQGAIRVTVARWLTPNKRQINGTGLTPDVEVPMTEEDIKAEKDPQLDKAIELLKSGNPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Q0</accession>
    <name>E8N4Q0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xre family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559798.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63414">
        <property type="protein sequence ID" value="BAJ63414"/>
        <property type="gene ID" value="ANT_13860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13860"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1232932_0_0_0"/>
    <dbReference type="OrthoDB" id="1069752at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="224" mass="25811" checksum="B96C6784B579C4F3" modified="2011-04-05" version="1">MDNRLILIRRKKLGAILYDSRRSLCRSLEDCARILGISPEEYSQFERGEGSPTLPQLELLSLYLNVPIDVFWDNRPVSAERQETLPENVSTALKLRNRIIAASLRLFRQKKGISTGELAQKTGIEEDVLLAYENGTREIPLPELETFAEALEVPLSQFLDEKGPIAKRRLQKQWAEQFENLPEEMQQFIAQPVNRPYLELAMRLSELDANRLRLIAESLLEITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X1</accession>
    <name>E8N4X1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-dependent helicase</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559867.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14570"/>
    <dbReference type="EnsemblBacteria" id="BAJ63485">
        <property type="protein sequence ID" value="BAJ63485"/>
        <property type="gene ID" value="ANT_14570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14570"/>
    <dbReference type="eggNOG" id="COG1111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_0"/>
    <dbReference type="OMA" id="CIQSPKC"/>
    <dbReference type="OrthoDB" id="35275at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="65"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="284"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="844" mass="94490" checksum="54694C1477ACC0E1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X6</accession>
    <name>E8N4X6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14620"/>
    <dbReference type="EnsemblBacteria" id="BAJ63490">
        <property type="protein sequence ID" value="BAJ63490"/>
        <property type="gene ID" value="ANT_14620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14620"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113198_4_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="122" mass="13277" checksum="FDE2792F267CC088" modified="2011-04-05" version="1">MKEDFHMEQTPSTTGKTTIAPEVLLTIARLNTLSVPGVARLSSAPADVNQIFSKNPQEGVKISVDHGVVYADIYVVLAKDVNVREVGRAIQQKVSRAISEMLGMEVGKINVHVEDIDYSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y8</accession>
    <name>E8N4Y8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trmU</name>
        <name evidence="7" type="synonym">mnmA</name>
        <name evidence="8" type="ordered locus">ANT_14740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559884.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14740"/>
    <dbReference type="EnsemblBacteria" id="BAJ63502">
        <property type="protein sequence ID" value="BAJ63502"/>
        <property type="gene ID" value="ANT_14740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14740"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_0_0_0"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="307"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="7">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="361" mass="40374" checksum="12BCA5A58FCAA075" modified="2011-04-05" version="1">MAIRDETVVVAMSGGVDSSVAAALLVEQGYRVIGMMLRLWSEEGKEDQNRCCTPDAMALARRVAAKLGIPFYAVDVREKFKEVVVSHFLEGYASGITPNPCLKCNRYIRWGVLHEYAQSLGATWFATGHYARLRRLESGEVQLLRGVDVEKDQSYVLSVLPQEQLRHTFFPVGEYHKPEVRELARRFGLPVANRADSQDLCFLAGGDYRDFLSRHAPEVSRPGVIVNRQGEILGEHQGLAFYTIGQRKGLGIAFPRPLYVLEKDVVRNRLVVGEEHELGRSTLIAERVNWISGQPPVSSIQVEVKIRYKAREAHGVVIPLTPDRVKVEFDHPLRDITPGQQCVFYQGEICLGGGTISTGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z8</accession>
    <name>E8N4Z8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glyceraldehyde-3-phosphate: ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559894.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63512">
        <property type="protein sequence ID" value="BAJ63512"/>
        <property type="gene ID" value="ANT_14840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14840"/>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440510_0_0_0"/>
    <dbReference type="OMA" id="CRFHRGW"/>
    <dbReference type="OrthoDB" id="206208at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="677" mass="77905" checksum="C0641E7F922203DD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8N509</accession>
    <name>E8N509_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrrolidone-carboxylate peptidase</fullName>
            <ecNumber evidence="9">3.4.19.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyroglutamyl-peptidase I</fullName>
            <shortName evidence="9">PGP-I</shortName>
            <shortName evidence="9">Pyrase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pcp</name>
        <name evidence="12" type="ordered locus">ANT_14950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559905.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14950"/>
    <dbReference type="MEROPS" id="C15.001"/>
    <dbReference type="EnsemblBacteria" id="BAJ63523">
        <property type="protein sequence ID" value="BAJ63523"/>
        <property type="gene ID" value="ANT_14950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14950"/>
    <dbReference type="eggNOG" id="COG2039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_4_2_0"/>
    <dbReference type="OMA" id="HHIATRA"/>
    <dbReference type="OrthoDB" id="1927224at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00417">
        <property type="entry name" value="Pyrrolid_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029762">
        <property type="entry name" value="PGP-I_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00504">
        <property type="entry name" value="pyro_pdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 11">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="205" mass="22492" checksum="356A26A6871B5A06" modified="2011-04-05" version="1">MKHWLITGFEPFDGSHVNPSAQIVTALSQSIFPEHFHGLILPVNAKTAPAILVENLQQIRPQAVLCLGEAAGRTAISIERVAINLMDFRIPDNAGEQVTDQPIAPDGPTAYFSRLPVRKIRDGLLAEGVPAELSYSAGAYLCNQVFYTLMHFLATHNMDIPAGFIHVPSLPEQAARRTSLTPSMSMELQIEAIRKVIEIVETENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N530</accession>
    <name>E8N530_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_15160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15160"/>
    <dbReference type="EnsemblBacteria" id="BAJ63544">
        <property type="protein sequence ID" value="BAJ63544"/>
        <property type="gene ID" value="ANT_15160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15160"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020359_0_0_0"/>
    <dbReference type="OMA" id="PKWRFQA"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025666">
        <property type="entry name" value="PQQ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="PQQ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="630" mass="70235" checksum="6C3C68ECA8BBA193" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J7</accession>
    <name>E8N5J7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560090.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63711">
        <property type="protein sequence ID" value="BAJ63711"/>
        <property type="gene ID" value="ANT_16850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16850"/>
    <dbReference type="eggNOG" id="ENOG50300IP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_328091_0_0_0"/>
    <dbReference type="OrthoDB" id="1442184at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001769">
        <property type="entry name" value="Gingipain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01364">
        <property type="entry name" value="Peptidase_C25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_C25" evidence="2">
        <location>
            <begin position="635"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="876" mass="97851" checksum="F0A23CD37D27016F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K4</accession>
    <name>E8N5K4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="10">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gid</name>
        <name evidence="10" type="synonym">trmFO</name>
        <name evidence="12" type="ordered locus">ANT_16920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560097.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16920"/>
    <dbReference type="EnsemblBacteria" id="BAJ63718">
        <property type="protein sequence ID" value="BAJ63718"/>
        <property type="gene ID" value="ANT_16920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16920"/>
    <dbReference type="eggNOG" id="COG1206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033057_1_0_0"/>
    <dbReference type="OMA" id="MHRNTFL"/>
    <dbReference type="OrthoDB" id="516534at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="11">
        <location>
            <begin position="3"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="456" mass="50351" checksum="DA749754F9032638" modified="2011-04-05" version="1">MADIIIIGGGLAGSEAAWQAAKAGLKVDLYEMRPQKSTGAHSTSFLGELVCSNSLGSALVDRASGLLKEELRLLGSLLLSVAEECALPAGGALAVDREMFAQTITEKIESHPNIRVIREEYPTIPSRPAIIASGPLTSPTLSKAIQELTGTEHLFFFDAIAPIVRAETINMEKAFRASRYQRGVIEEGDYINCPFTREEYEQFIEALLNSERIPLREFEEEIKHGVRAGAHEYFEGCLPIEVLAARGKEALAFGPMRPIGLRDPHTGKRPYAVVQLRQDNLAGTLYNLVGFQTNLTFPEQRRVFRMIPGLENAEFVRYGQMHRNTFIASPALLLPTLQFRKRSDLFFAGQITGVEGYMGNIATGLLAGINAARLLKGETPVSLPETTMLGALCHYVTHASLKDFQPMKANFGILPALPDPAPGKSQRALQYVERALNNLRKWAEKNYIPLEDRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P5</accession>
    <name>E8N5P5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560137.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63759">
        <property type="protein sequence ID" value="BAJ63759"/>
        <property type="gene ID" value="ANT_17330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17330"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005647_0_0_0"/>
    <dbReference type="OMA" id="AFWLMEG"/>
    <dbReference type="OrthoDB" id="76786at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="293"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1153" mass="133900" checksum="DE1732CF71A401AB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T7</accession>
    <name>E8N5T7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DRTGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17750"/>
    <dbReference type="EnsemblBacteria" id="BAJ63801">
        <property type="protein sequence ID" value="BAJ63801"/>
        <property type="gene ID" value="ANT_17750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17750"/>
    <dbReference type="eggNOG" id="COG4109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140224_1_0_0"/>
    <dbReference type="OMA" id="VTIQTHV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="120" mass="13027" checksum="16C58982CFCBEA1F" modified="2011-04-05" version="1">MNLTLGQIAKTLNLDLLTQSVDWEEIRPTAGYTSDMLSCVMAGAPHRSIWITLQAHMNIIAVAALLELSAVIITEGAQPEPNTIEKANEKGVILFSTKASSFEVAGRLWEMGLRAVSSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W8</accession>
    <name>E8N5W8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transaldolase</fullName>
            <ecNumber evidence="6">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tal</name>
        <name evidence="8" type="synonym">pgi</name>
        <name evidence="8" type="ordered locus">ANT_18060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GPI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560210.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63832">
        <property type="protein sequence ID" value="BAJ63832"/>
        <property type="gene ID" value="ANT_18060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18060"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013922_0_0_0"/>
    <dbReference type="OMA" id="YKGGPDS"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="925" mass="102740" checksum="766194D32F89A737" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5X9</accession>
    <name>E8N5X9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18170"/>
    <dbReference type="EnsemblBacteria" id="BAJ63843">
        <property type="protein sequence ID" value="BAJ63843"/>
        <property type="gene ID" value="ANT_18170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18170"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_7_0"/>
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    <dbReference type="OrthoDB" id="1473468at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="33252" checksum="0806D13C3F77F7B3" modified="2011-04-05" version="1">MEQMKFSLDHVLAQLPRPPRRVVSLVPSYTESLFELGFGSSVVGITDYCIHPSNALKNIPRVGGPKNARLESILSLEPELVLANPEENPADLVFALFEKGIPVWVSFPQTVQDAIQFLWGLVDLYRDKQAALKVRVLEQSWEFARQVSESLPRFRYFCPVWEETLTGQIRWITFNDQTYPADLLSLFGGENIFGAKQKEKPSGEGQDLDLRYPVVTPDEVCSGDPEVILLPDEPFSFESSAVERFIKLFQNTPAVKKNRIWLIPGDTLFWYGVRLGKALSDFPEVFSSLYSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y3</accession>
    <name>E8N5Y3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_18210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18210"/>
    <dbReference type="EnsemblBacteria" id="BAJ63847">
        <property type="protein sequence ID" value="BAJ63847"/>
        <property type="gene ID" value="ANT_18210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18210"/>
    <dbReference type="eggNOG" id="ENOG5034C6D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010501_0_0_0"/>
    <dbReference type="OMA" id="RGPEWAN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="123" mass="13619" checksum="77D632669F63A847" modified="2011-04-05" version="1">MYNPDTDLLFPLRVVPQLRSLRGPEWANLIDEVLSEKAGLAEKSAFVLLMVKLSGCNTCNSDSFRAMRGCTACARQVVRRFRGSDMELLQQYRALVSEVQQFISIQFSGGLNSPSQSLGDTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N639</accession>
    <name>E8N639_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_18770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560280.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63903">
        <property type="protein sequence ID" value="BAJ63903"/>
        <property type="gene ID" value="ANT_18770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18770"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="REYAMLD"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="6">
        <location>
            <begin position="265"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="349" mass="38850" checksum="D6820F601D5C2785" modified="2011-04-05" version="1">MPNQMTAEPLIVCENLVKIYKIADLEVVALQGLDLVVPRKEMLAIVGASGSGKTTLMNILGGLDRPSAGKVTVDEIDLLSLSDEALNEYQRTKVGFVWQQTSRNLIPYLTAEENIELPMIMSGVHNKQQRREWAHELLNSVGLFHRRHHQLIQLSGGEQQRIAIAVALANRPVLLLGDEPTGEVDSATARTIMETFSRLREELDLTIVIVSHDPRIAEQVDRVVAIRDGKIATETVRQVSQLEALMAGGASGSQEILLPSQVTYKEFVMLDSAGRLQIPKEIREELGIGKRVEMQIEDGRIIIKPVEGEGGEPLKNLTIEEQIAILFSGEKVPQRKPGSVKKLKWLRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8N660</accession>
    <name>E8N660_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplK</name>
        <name evidence="11" type="ordered locus">ANT_18980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560301.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63924">
        <property type="protein sequence ID" value="BAJ63924"/>
        <property type="gene ID" value="ANT_18980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18980"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_2_0"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="141" mass="15042" checksum="582B23E6BDD9A699" modified="2011-04-05" version="1">MAKKLKAIVRLQLRGGKATPAPPVGPALAGHGINIMAFCKEYNARTSNRAGELIPAEITVYTDGSFTFILKSPPASELLKKAAGIEKGSSAPNRDKVGKVTRAQIREIAEIKMKDLNAIDIEGAMKQIEGTARNMGIIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N677</accession>
    <name>E8N677_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560317.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63941">
        <property type="protein sequence ID" value="BAJ63941"/>
        <property type="gene ID" value="ANT_19150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19150"/>
    <dbReference type="HOGENOM" id="CLU_851638_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="38353" checksum="96C4CF40EE1A6F94" modified="2011-04-05" version="1">MLLTFDEVFGWLNRFTPTHLSNRDILNFFQLSDNRLSNTAKMDALEELKRAAANTPRPLHSAEIRLGIARYFFADQDLRNAYAEAVRATELFRPGSHQHGVALWLLGMIEWGLLENANAYSHWFLARRTFVECQAQRSQLGDADGVNWYVHCLEEMNIDMAGTVEEAEYWLNLFEPSKINEVAKHYVDRLREQIIQRRFPEAYEVSRLLMSIGRSNLDPQETGEIWVKLAVAIQQMGELRRAINFLEKACAAFAPYTHPWAVVKWMMGLLYARIPQEREKGLKFLMEAITIFEELIRTYDFRREIQRRDWYQIKITQMHRVIAELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B0</accession>
    <name>E8N6B0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c-type biogenesis protein CcmF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ccmF</name>
        <name evidence="10" type="ordered locus">ANT_19480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560347.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63974">
        <property type="protein sequence ID" value="BAJ63974"/>
        <property type="gene ID" value="ANT_19480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19480"/>
    <dbReference type="eggNOG" id="COG1138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015041_3_0_0"/>
    <dbReference type="OMA" id="SYWGMQL"/>
    <dbReference type="OrthoDB" id="213184at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032523">
        <property type="entry name" value="CcmF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003567">
        <property type="entry name" value="Cyt_c_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003568">
        <property type="entry name" value="Cyt_c_biogenesis_CcmF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43653">
        <property type="entry name" value="PTHR43653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16327">
        <property type="entry name" value="CcmF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01410">
        <property type="entry name" value="CCBIOGENESIS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01411">
        <property type="entry name" value="CCMFBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16327"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ63974.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="685" mass="76676" checksum="F5D9A12361EA3762" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C7</accession>
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        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
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    <reference evidence="2 3" key="1">
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            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63991">
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    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19650"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="CAVACIR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="28"/>
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        <location>
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            <end position="54"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="94"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        <source>
            <dbReference type="EMBL" id="BAJ63991.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="706" mass="80074" checksum="8699EF4BE4635553" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
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        <name evidence="3" type="ordered locus">ANT_20010</name>
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        <dbReference type="NCBI Taxonomy" id="926569"/>
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                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="BAJ64027">
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    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="AVWSGDT"/>
    <dbReference type="OrthoDB" id="377638at2"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AMP-binding_CS"/>
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    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="426"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="514" mass="57643" checksum="F254EBF7DB8E7AC9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF6</accession>
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        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
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        <name evidence="3" type="ordered locus">ANT_20110</name>
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        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ANT_20110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20110"/>
    <dbReference type="eggNOG" id="COG1835">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transf_3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="7"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="359" mass="41085" checksum="FC52FFC0F5253AD5" modified="2011-04-05" version="1">MAKRLFWLNGIAILAVVINHAIGWGFTALFWWTDRYRDVSIPNFDAMGSPGYVLMVILKQITPFSLPAFVAVSGYFIAFASRGGLTWKMIRTRVINILIPYTLWSLLVILFDRLLLDTQISLLDILTKLLTGSASPIYYYVPLICQLFLLSPFLVRGVRSSQWKKLLLGMGFLQVVTVGWSYLVLFGILSWKPEWFFGNLGFIFTLSIALNLRGEEILPWLKAHRKIWLGLLIVFLPLAIGETEWFYQSYGIDWRGGVETLFATVFTLLFLLTFITYDFSLPQSTVLYKLGQRAFGIYLMHPLVLEITAKLVYHLAPALLGNQWIFLPLLITTGIVVPWFAMKFMSETPLRKGYAYIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH4</accession>
    <name>E8MXH4_ANATU</name>
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        <submittedName>
            <fullName evidence="1">Putative glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
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            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560425.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20290"/>
    <dbReference type="EnsemblBacteria" id="BAJ64055">
        <property type="protein sequence ID" value="BAJ64055"/>
        <property type="gene ID" value="ANT_20290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20290"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_0_5_0"/>
    <dbReference type="OMA" id="FFCYCED"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="297" mass="34025" checksum="EB5078E4C99C705D" modified="2011-04-05" version="1">MNQKVLAIVLNWNKPEDTLRCLETLGDSIPRLVVDNGSAPESRAILLKSIQGIPVIELPENRGYAGGNNAGIRWALEHGFEWILLINDDALLKSSELFRLLQIAETDPLVGFAGPLVLHAEREDLIQSAGGVLSPLWQTFHRGQNQVNQGQYSQHEPVDWLSGCVLLARSEMIKEIGLLDESFFLYEEELEWCIRARRAGWKCLFVPEVQARHAGVRPDYEPPPYVTYYMYRNHFRLLAKHRAGLLPWGYALFQSMRTLISWSVRPKWRSKRSHRDALWLALKDFLQGKSGQLSQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH7</accession>
    <name>E8MXH7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560428.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20320"/>
    <dbReference type="EnsemblBacteria" id="BAJ64058">
        <property type="protein sequence ID" value="BAJ64058"/>
        <property type="gene ID" value="ANT_20320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20320"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_0_1_0"/>
    <dbReference type="OMA" id="NGFDNEY"/>
    <dbReference type="OrthoDB" id="246964at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="304" mass="35559" checksum="6960014890185D0D" modified="2011-04-05" version="1">MDLSIVIVSWNVASYLENCLDSIFQNAPNCSFEVWVVDNASVDQSVQIIKKRFPQVHLVENSQNVGFAEANNQAIRQSKGRYVLLLNPDTLVHPYALQRLVDFMDGHAEAGAAGSLYLSPNGKMQHSCMPFPTVSREFWRLFHLDALWHYGTYNMERWDRQKEREVESLQGACLILRHSVLDEVGVLDPDYFMYTEEVDLCYRIHHKGWKLYWVPQSVITHFGGQSTRQTAKQMFLWLYRSKIMFIRKHFGEKKAQEYKQVIRWASLLRIGIAPFVQLLQSFTPKDYVKNIENYRELMKQLPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI6</accession>
    <name>E8MXI6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_20410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560437.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20410"/>
    <dbReference type="EnsemblBacteria" id="BAJ64067">
        <property type="protein sequence ID" value="BAJ64067"/>
        <property type="gene ID" value="ANT_20410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20410"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="FIINVRG"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="226" mass="25599" checksum="BD6FDF131E37FC98" modified="2011-04-05" version="1">MSTVLLIEDETELARVAQSYLEKAGFQVILASRGDTGLSLFRQHKPDLVLLDLNLPGMDGLDVAREIRRQSDVPLIMVTARVEETDRLIGLELGADDYIVKPYSVRELVARVRAVLRRFNRSSGGSQILREGNLEVDLDTHTVKRGDEEIFLTPTEFQLLSTLMAQPGRVFTRLQLLEAIQGVAYEGYERTIDAHIKNLRAKIEEDPHHPHYVETVFGVGYRFRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI7</accession>
    <name>E8MXI7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">ANT_20420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560438.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64068">
        <property type="protein sequence ID" value="BAJ64068"/>
        <property type="gene ID" value="ANT_20420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20420"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_3_0"/>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="594"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="776"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1129" mass="128302" checksum="4C08D98B9EDA5221" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ6</accession>
    <name>E8MXJ6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="6">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">fni</name>
        <name evidence="8" type="ordered locus">ANT_20510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560447.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20510"/>
    <dbReference type="EnsemblBacteria" id="BAJ64077">
        <property type="protein sequence ID" value="BAJ64077"/>
        <property type="gene ID" value="ANT_20510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20510"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065515_1_0_0"/>
    <dbReference type="OMA" id="WDWGIPT"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="7">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_dh" evidence="7">
        <location>
            <begin position="178"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="273"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="294"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="36837" checksum="95E5765F3B9B1A86" modified="2011-04-05" version="1">MDHLPSTESRKSDHIRINLEEDVRSALTTGLERFFFIHEALPEVNLEEIDLHLELFGKTLNAPILISSMTGGTEKAGLINQRLAEAAQATGIAMGVGSQRVALENPQAGASFQIRQFAPDILLFANIGAVQLNYGYAVEHCQRAVDMIQADALILHLNSLQEAIQPEGDTRFAGLLGKIEQVCKQVSVPVIAKEVGWGISERTARMLVDAGVSAIDVAGAGGTSWSQVEMYRIQDERRARIAAAFRNWGIPTAYSIQMVKKVAPHVPIIASGGLKTGVDIAKCIALGACMGGMAGQFLKAATQSTEAVIELIEETREEIRITMFGVGAANLKALSSTPLIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL8</accession>
    <name>E8MXL8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mutS</name>
        <name evidence="10" type="ordered locus">ANT_20730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560469.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64099">
        <property type="protein sequence ID" value="BAJ64099"/>
        <property type="gene ID" value="ANT_20730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20730"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_3_1_0"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="15991at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="9">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="614"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="858" mass="96234" checksum="2328D735DBDDB141" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT9</accession>
    <name>E8MXT9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560540.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21440"/>
    <dbReference type="EnsemblBacteria" id="BAJ64170">
        <property type="protein sequence ID" value="BAJ64170"/>
        <property type="gene ID" value="ANT_21440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21440"/>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965228_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="288" mass="30614" checksum="656E4AC450962022" modified="2011-04-05" version="1">MDVNQLLMPVSLALLAWGIAQNVKIGGGKTARALQDYYAAQTPKQSRQEAIGEAVAGRLLSLKTWEDHLRWAQRGGQYLGQSLGGVVFQSLLFAGAGLLVVMVNPAPLSLLVPVMAFAYPLVRLRSKANTVRKRVFRTLPETAALIAAELAAGTAPDVAVARAAAIPGPLSALLKEAVEQSRQTGRPLFSRKPIGGTLVEVMGHSGIPALHAFGSQLDLVASKGVAGAALMSEIARALGQEYRARLQSEVEKLDSRLTLVVALFFFVPFVGLLLFASLRPVLQIFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY5</accession>
    <name>E8MXY5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64216">
        <property type="protein sequence ID" value="BAJ64216"/>
        <property type="gene ID" value="ANT_21900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21900"/>
    <dbReference type="HOGENOM" id="CLU_1552106_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="172" mass="19067" checksum="2E29C73D1D24DE2D" modified="2011-04-05" version="1">MCAHVLPLNYSRTFPLLTTAGGLVPLAFPQVPSFGRRCYVRPRRGRVCAWFRIRTPRSTCATYTGCPCRPAAQSIPVPPRDRIGAVSRFRCRRVVSAARRIHGQDSWRFTLYTARSLPCIAQGSQSSPGRGSLACFYPILSWAVYRTRFLASEGLPACLPLPVFPGCHLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ8</accession>
    <name>E8MXZ8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase, chain 49kDa family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_22030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560598.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22030"/>
    <dbReference type="EnsemblBacteria" id="BAJ64229">
        <property type="protein sequence ID" value="BAJ64229"/>
        <property type="gene ID" value="ANT_22030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22030"/>
    <dbReference type="eggNOG" id="COG3261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_0"/>
    <dbReference type="OMA" id="CDPCFTC"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="4">
        <location>
            <begin position="122"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="4">
        <location>
            <begin position="290"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="393" mass="44562" checksum="F8835FAD158AC801" modified="2011-04-05" version="1">MTSERKFIVPIGPQHPALKEPGHFEFTVDGEIVTDASVRLGYVHRGIEKGAEERSWIQDLYLFERVCGICSHVHATAFALGVERLAGVEAPPRAQAIRSLVAEMERIHSHMLWLGVAAHEGGFDTLFMYSWRDREIVMDLLEALTGNRVNYSANVLGGVKCDITDTLRDQILRGMDQLEERIQHYLNVVTTDRTFLARTEGVGRMTREQADLFGAVGPTARASGVPRDVRVDAPYAFYPTVPVQLITDERGDLLARFVVRIKELFEAVRLIREILAHLPEGELTVRMPRRIPAGEVISRVEAPRGELFYFIKSNGGEKPERVKVRTPSLCNWGSVMQVAVGHKLADMPMILAGIDPCFSCNDRMIQLKRKDSRQWMTWEDLRQYGIEYYKKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY38</accession>
    <name>E8MY38_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rpsR</name>
        <name evidence="5" type="ordered locus">ANT_22430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22430"/>
    <dbReference type="EnsemblBacteria" id="BAJ64269">
        <property type="protein sequence ID" value="BAJ64269"/>
        <property type="gene ID" value="ANT_22430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22430"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_2_2_0"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="90" mass="10689" checksum="B89D08706BC280CC" modified="2011-04-05" version="1">MSDEMMMDMEQPQMRRYVARPKICQFCVDKNIKIDYKAVDLLRRYVTEEGKIRPRRQTGTCAKHQRELATAIKRARHLAFLPFVASDEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY54</accession>
    <name>E8MY54_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal-phosphate dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_22590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ACC deaminase/D-cysteine desulfhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560653.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64285">
        <property type="protein sequence ID" value="BAJ64285"/>
        <property type="gene ID" value="ANT_22590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22590"/>
    <dbReference type="eggNOG" id="COG2515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048897_1_0_0"/>
    <dbReference type="OMA" id="LVQEKWV"/>
    <dbReference type="OrthoDB" id="1714795at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43780">
        <property type="entry name" value="PTHR43780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006278">
        <property type="entry name" value="ACCD_DCysDesulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="7"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006278-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="323" mass="35139" checksum="3900FD0FC316B02D" modified="2011-04-05" version="1">MIPRLKLAALPTPIEFLPRLGAYLGGLRILIKRDDLTGVAFGGNKTRKLELVLAEAQSVGAHTLITVGAVQSNHCRQVAALAARMGLKCKLVLYGEIPSRASGNLFLDRLFGAEIFWTSKDARNETLNEVFGESWARGERPYLIPLGASNPLGAAAYALAFDEMLQQIQSERVDWIVVASSSGGTQAGLVLGAHRRHFHGRILGISIDEPERELKEVVAFLAREASDRLGKAMTIHPEDVFVNADYLGGGYGVMGEAEREAITLFAQLEGVLLDPVYTGRAAAGLIDLARKGFFHRGETILFWHTGGTPALFADKYQNQLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY82</accession>
    <name>E8MY82_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrimidine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="6">2.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pdp</name>
        <name evidence="6" type="ordered locus">ANT_22870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.2" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560680.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22870"/>
    <dbReference type="EnsemblBacteria" id="BAJ64313">
        <property type="protein sequence ID" value="BAJ64313"/>
        <property type="gene ID" value="ANT_22870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22870"/>
    <dbReference type="eggNOG" id="COG0213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_0_1_0"/>
    <dbReference type="OMA" id="DVWRRMI"/>
    <dbReference type="OrthoDB" id="1724909at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="434" mass="46383" checksum="C7EDF927600BF2DA" modified="2011-04-05" version="1">MRAVDIIIKKRDKGVLTREEIDFFVEGFTRGDIPDYQAAAFAMAVMLNGMNAEETTYLTLAMARSGEVLDLTGVVDFVVDKHSTGGVGDKTTLVVEPAVATCGLPVGKMSGRGLGFTGGTLDKLESIPGYRTDLSTEEFIQQLKEIGLVLTGQSKDLSPADGKLYALRDVTGTVPSIPLIASSVMSKKIAGGAHAIVLDVKVGLGAFMETLESARELSRLMVDIGRLSGRKVVALLSDMNQPLGQAVGNALELKEAIDTLHGGGPEDFREHCLVVASHMLKVGGKAASLEEARQMVERVIAEGKAWEKFRQLVAAQGGDVSYVDHPEKLPAAPVVYPVLAQHSGYLAQVHARMVGETAVVLGAGRSKKEDPIDHGVGIIVHVKVGDRVEKGQPLFTVHARTEADARMAEARLLDALTWSEHSVSPLPLFYGVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY95</accession>
    <name>E8MY95_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_00060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558438.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00060"/>
    <dbReference type="EnsemblBacteria" id="BAJ62040">
        <property type="protein sequence ID" value="BAJ62040"/>
        <property type="gene ID" value="ANT_00060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00060"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370351_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="560"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="751" mass="85919" checksum="48271417DD0697DC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF1</accession>
    <name>E8MYF1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558494.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00620"/>
    <dbReference type="EnsemblBacteria" id="BAJ62096">
        <property type="protein sequence ID" value="BAJ62096"/>
        <property type="gene ID" value="ANT_00620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00620"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_0"/>
    <dbReference type="OMA" id="RRKWYFP"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="375" mass="41805" checksum="ABCDB6499BB75995" modified="2011-04-05" version="1">MKIACIATAQVPSITANSIQVMKVCHALARNGHEITLYVPGRQATEWEHLADLYGITQKFSIRWVPALPLWKRNDFALQAVRLARRERAELIYTWAIQSAALALMLGMPAVYEAHDLPTGRLGPLWMQAFLRLPGRKRLVCITRALRRALEARLRVHLPEHQVVIAPNGVDLERYRHLPDPPTARAQVGMAQSLTVGCSGHLYAGRGGDLFLALAQRFPHAQFLWAGGRDEDVQTYRQRAQEQALENVTFTGFIPQTRLPLVQAAADVLLMPYGRSIAGSSGGNSAEICSPMKLFDYLAVGRAILSSDLPVIREVLDEDTARFAPPEDVEGWAAALAPLLADETLRQRLAEQARKRAEQYDWQERQQRILGGGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM1</accession>
    <name>E8MYM1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraW</name>
        <name evidence="6" type="synonym">rsmH</name>
        <name evidence="7" type="ordered locus">ANT_23310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560723.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64357">
        <property type="protein sequence ID" value="BAJ64357"/>
        <property type="gene ID" value="ANT_23310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23310"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_3_0_0"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="312" mass="34721" checksum="799E6E89D42B0772" modified="2011-04-05" version="1">MSEASVPHRPVLYQEIILALRPHSPGRYVDATVGAGGHAAGILEASSPKGELLGLDPDPQALALASQRLSIFGERVHLVQASYVTLKEQLAVLGWQEVDGIVFDLGVSSMQLDTPERGFSFSAEGKLDMRFDPCQDTTAEDLVNHLPEEELARILWEYGEERYARRIARAIVQARPLHTTRELAELVARIVGGKRERIHPATRTFQALRIAVNRELEAIETVLPQAVECLKAGGRLAVISFHSLEDRLVKHFFRRESRDCLCPPEQPVCTCGHKASLREVTRHPIEASDEEVRENPRARSARLRVAEKIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM8</accession>
    <name>E8MYM8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="13" type="ordered locus">ANT_23380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23380"/>
    <dbReference type="EnsemblBacteria" id="BAJ64364">
        <property type="protein sequence ID" value="BAJ64364"/>
        <property type="gene ID" value="ANT_23380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23380"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_0_0"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="187"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ64364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="39957" checksum="13A36E806CDD514D" modified="2011-04-05" version="1">MRLLICAGGTGGGVYPALSILQALKNEANPVLWVGGEGGMEAELVKKAGLPYTAIPAAGVHGVGLRALPGNILRLARGVLASRRILKEFQPEVLLFTGGYLAVPMALAGRHIPSLLYVPDIEPGLALKTLSRFASTIALTAEPSRTFFKHSKARVEVTGYPVRQDLLEWNRERGAEKLGLDAQQPILLVTGGSKGARSINRAIVKGLPELLQVTQICHLTGALDWEEVQMAREALSPDLQKRYFAAPYLHEMGAALACADLVISRAGASTLGEYPLFGLPAILVPYPYAWRYQKVNAMYLVEQGAAVMIENQNLAEQLVPTVLRLIGSPEKLAAMRKAMRTLHRPQAAERIASLVLALAQPQHGDNSWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW2</accession>
    <name>E8MYW2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560803.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64448">
        <property type="protein sequence ID" value="BAJ64448"/>
        <property type="gene ID" value="ANT_24220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24220"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_0"/>
    <dbReference type="OMA" id="FAKNIWH"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="112" mass="12478" checksum="F75B6057C9964784" modified="2011-04-05" version="1">MKRGEVWLVNLDPTLGAEMRKSRPAVIVSSDLVGVLPLRVIVPLTDWKERYSVAPWMVQIKAASSNGLDKDSAADCFQVRSVSTMRLVRKIGRLSPEDMEKIVQSIQLVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYZ1</accession>
    <name>E8MYZ1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">rnhB</name>
        <name evidence="14" type="ordered locus">ANT_01000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558532.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01000"/>
    <dbReference type="EnsemblBacteria" id="BAJ62134">
        <property type="protein sequence ID" value="BAJ62134"/>
        <property type="gene ID" value="ANT_01000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01000"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_3_2_0"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ62134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="224" mass="24219" checksum="7E58B27722CBFA42" modified="2011-04-05" version="1">MARPPLADLPHDPTLAFEQSLWQAGVLHVAGVDEAGRGAWAGPVAAAAVILPSGDSALLERLHGVRDSKQMTAKAREGFAEVIRQTALAWGVGFASVEEIETQGIVPATRLAMMRALQACALSPTHLLIDALRLPEIPLPQTSLIKGDARSLSIAAASVLAKTARDALMRDLARQYPQYGFELHKGYGTARHRAALEQWGPCPLHRRTYRPVMHLSDLWEKSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYZ6</accession>
    <name>E8MYZ6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative opine dehydrogenase</fullName>
            <ecNumber evidence="4">1.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_01050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.1.28" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558537.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01050"/>
    <dbReference type="EnsemblBacteria" id="BAJ62139">
        <property type="protein sequence ID" value="BAJ62139"/>
        <property type="gene ID" value="ANT_01050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01050"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056511_2_0_0"/>
    <dbReference type="OMA" id="LMMLMNA"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047129">
        <property type="term" value="F:opine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003421">
        <property type="entry name" value="Opine_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02317">
        <property type="entry name" value="Octopine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Octopine_DH" evidence="3">
        <location>
            <begin position="190"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="369" mass="40057" checksum="0BBE27147803EE9E" modified="2011-04-05" version="1">MTQTLSITVIGAGHGGKAMAAHLALMGHRVKLFNRTADHIFAIQQRGGIDLESQEYGPRGFGKLECATSDMGEALADAQLIMVVVPSSAHADIARAAAPHLKDGQVVVLHPGRTCGAIEFVMVLRRSGCQADVTVAEAETFIYASRSDGPAQARIFRIKEAVPLAALPAKRTHEVLDLIHVVYPQFIDGGNVLQTGLNNMGAIFHPALTLLNAGWIEATHGDYQFYIDGVTPSVARVLEALDRERITVAAALGIRARSALEWLKMAYDAVGSDLREAIHNQPGYYGIKAPTTLNHRYIFEDVPMSLVPIASLGMQYGVSVRGMDSIIRLACIVHNTDYWRRGRTVENLGLRGLSVEELTHFVMEGELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ17</accession>
    <name>E8MZ17_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_01260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62160">
        <property type="protein sequence ID" value="BAJ62160"/>
        <property type="gene ID" value="ANT_01260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01260"/>
    <dbReference type="eggNOG" id="COG0549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076278_0_0_0"/>
    <dbReference type="OMA" id="QPMDVAG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="34610" checksum="E877C87A22CC27E9" modified="2011-04-05" version="1">MKMSRKKTAVIAIGGNSLIKDNAHQKIEDQYQAAKETCYHIADMIEAGWNVAIGHGNGPQVGLILRQSEVAAKVEHLPETPLDVCGAESQGLIGYLLQQNLQNELFRRKIHQNVATVITQVLVDKNDPAFQHPTKPIGGFMTEEEAKRKAEELGWTVVEDAGRGWRRVVASPDPKEVVELDTIKALIEAGVIVITVGGGGIPVIDKGDGDYVGIAAVIDKDFASSLLAQEINADIFIISTAVEKVALNYGKPNEKLIDRMTVAEAKQYIQEGHFAKGSMLPKVQACIRYLEAGGKEALITSPENIGRALRGETGTWIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ33</accession>
    <name>E8MZ33_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_01420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558574.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62176">
        <property type="protein sequence ID" value="BAJ62176"/>
        <property type="gene ID" value="ANT_01420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01420"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699501_0_0_0"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="394" mass="41987" checksum="F8599EA76298C19C" modified="2011-04-05" version="1">MALRRILVVDDARDVGRMVQEALRSAYKGVPVVYAPSAEEAMLETSTMAVDLMIVDIRLPGMSGFDLVRRVRARQPEMQVIMITGLSPDENLKQMSAEVGAARLLSKPISIADLLSAVEEVVGVKGADLSLPAAKERKTTPRKSKTSELPPAVEIPAPPVEVPEAPLPSLSEVLANLRGSLGAYSVVLLDDAGHITARAGEWMPDQPEEHIVPAVLAAVSAVEKLGRQVLDGHASNALFVQGAQVQVVAAPVGRFTLVVYLRNGAGTLRLALAVEEILAAQTQIAETLERMGILIKPVTSTLTPPVEEASAAVGMSGLESPMEEVLAEETPVDLKGLEELLAKPEEVLPPVDADSFWDAVVEEKGEIKVNPDSLSFEEARKLGLLPPEDAEPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ34</accession>
    <name>E8MZ34_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="3 7">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gnd</name>
        <name evidence="9" type="ordered locus">ANT_01430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 7">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="3 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558575.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01430"/>
    <dbReference type="EnsemblBacteria" id="BAJ62177">
        <property type="protein sequence ID" value="BAJ62177"/>
        <property type="gene ID" value="ANT_01430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01430"/>
    <dbReference type="eggNOG" id="COG0362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_0"/>
    <dbReference type="OMA" id="VIMVKAG"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3 7" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="8">
        <location>
            <begin position="180"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="470" mass="51340" checksum="844962662F8724B9" modified="2011-04-05" version="1">MTLANIGVIGLGVMGRNLVLNMERNGFTVAVFNKTTAKMHEFIQGDAAGKRIVGYETLADLVKGLERPRRILLMVTAGAAVDAVIAELKPLLEPGDILIDGGNSYFLDTERRSRELEASGLWFVGMGVSGGEEGALWGPSIMPGGSPEAWQALAPILQAIAARAEDGAPCVTHIGPGGAGHYVKMVHNGIEYADMQLIAEIYDLLSRGAGMSADQLADVFAEWNEGELKSYLIEITSHVLRRKDDLTGKPLVDVILDEAQQKGTGKWTGQNALDLGAPVPTIQAAVESRSLSAMKERRVLASRVLGGPKPMYQGEVKPLVEAARQALYAAKIIAYAQGFELMSMASQEYQYNLQLAELARIWRAGCIIRAALLEEITAAYRRDPALPNLLLDPAFAQAVAERQTNWRWLMQTAIGMGIPTLALSSALAYYDAYRSERLPANLIQGLRDYFGAHTYRRLDREGVFHTRWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ66</accession>
    <name>E8MZ66_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_01750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558607.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01750"/>
    <dbReference type="EnsemblBacteria" id="BAJ62209">
        <property type="protein sequence ID" value="BAJ62209"/>
        <property type="gene ID" value="ANT_01750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01750"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="FNQMGRQ"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031967">
        <property type="entry name" value="PhoR_single_Cache-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16736">
        <property type="entry name" value="sCache_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="247"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="368"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="584" mass="65733" checksum="D77F8B223A5E2674" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA1</accession>
    <name>E8MZA1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62244">
        <property type="protein sequence ID" value="BAJ62244"/>
        <property type="gene ID" value="ANT_02100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02100"/>
    <dbReference type="HOGENOM" id="CLU_3264881_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="41" mass="4397" checksum="C4D38967B0C48DD5" modified="2011-04-05" version="1">MSTLVSLFADSRKVRLVVFALMLVLFILGAGAPEDAGGFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZB3</accession>
    <name>E8MZB3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truB</name>
        <name evidence="7" type="ordered locus">ANT_02220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02220"/>
    <dbReference type="EnsemblBacteria" id="BAJ62256">
        <property type="protein sequence ID" value="BAJ62256"/>
        <property type="gene ID" value="ANT_02220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02220"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_0_0"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="34"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="185"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="34005" checksum="0A197D34AB6D53E3" modified="2011-04-05" version="1">MMENPMDVRNTVSGVLVVDKPVGMTSHDVVQIIRKGTNIRRAGHTGTLDPRASGVLVVLIGPAVRLSEYVSASDKRYQAIIRLGTSTDTYDADGRITGSGSVPVESITEEQFEQALQQFVGEIEQVPPPYSAIKVQGRKAYEMAREGEEVDLAPRKIKVYSLELLEWAPPEAVVDIYCSSGTYVRSLAHDLGQVLGCGAHLVGLRRTKSGRFTLRDAVPLRKLREAFQDGTWYQYLIPAAEALADWPALELTDKQVEEVRHGHRIPAEEPVPGNMVRGVSVLGELVALLEYLPEENLWQPRKVFFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD6</accession>
    <name>E8MZD6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">ANT_24580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64484">
        <property type="protein sequence ID" value="BAJ64484"/>
        <property type="gene ID" value="ANT_24580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24580"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_1_0_0"/>
    <dbReference type="OMA" id="LYPPQNR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="344" mass="38956" checksum="4D037C014D102D23" modified="2011-04-05" version="1">MRLGGQNMPPLYVVQQNSKLRLNNRRVQVEQETDEGIQVLAQIPIGQVSEIILFGNVGLTTPLMDALLYEGIPVIFLTRDGDYRGILSGGLTPHVPLRRAQYRALEKPSFSLEMAKGFVRAKLRHQRTLLQRQNRPPKQDASLSEVIERMEHAIDEVQRKTSLSSLRGLEGSATAAYFSGLRQLFNPEWKFDARLRRPPPDPVNVLLSLGYTLLAQDCVAAVQAVGLDPYAGFLHEVAYNRPALGLDLLEEFRPLVDGVVLWICHSGKICPQQFTPGPPERPVVLDDQGKRDFIKAFEERMDSRFTHPLAQQQLTMRQCLIEQARQIAHRILEDRPGYDDMGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF0</accession>
    <name>E8MZF0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560853.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24720"/>
    <dbReference type="EnsemblBacteria" id="BAJ64498">
        <property type="protein sequence ID" value="BAJ64498"/>
        <property type="gene ID" value="ANT_24720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24720"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034370_1_0_0"/>
    <dbReference type="OMA" id="GLTQMRE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="402"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="562" mass="62545" checksum="AC1D966C3C5A8A6D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM9</accession>
    <name>E8MZM9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="12" type="ordered locus">ANT_25510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560932.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25510"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="BAJ64577">
        <property type="protein sequence ID" value="BAJ64577"/>
        <property type="gene ID" value="ANT_25510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25510"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_0"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="193"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="518" mass="57427" checksum="9B983BF6F9D476D4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN0</accession>
    <name>E8MZN0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">xpt</name>
        <name evidence="3" type="ordered locus">ANT_25520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560933.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25520"/>
    <dbReference type="EnsemblBacteria" id="BAJ64578">
        <property type="protein sequence ID" value="BAJ64578"/>
        <property type="gene ID" value="ANT_25520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25520"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099015_0_0_0"/>
    <dbReference type="OMA" id="HQVDPVL"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="73"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="1">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="192" mass="20742" checksum="DA59BA426C6C2841" modified="2011-04-05" version="1">MEALKQRILKDGKYLGRGILKVDNFINHQVDPELMDACGAEFARRFADVGATRILTAEISGIAPALMTGRHMNLPVVYARKSKPITMPDTVYLTVAPSHTKGVMTELIVSPEYLSAGERVLIIDDFLASGATILGLVRLAQAAGSQVVGIGTLVEKIFEGGRAALAHLNVPIHSLAVIERMDETGIYFVNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN3</accession>
    <name>E8MZN3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560936.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64581">
        <property type="protein sequence ID" value="BAJ64581"/>
        <property type="gene ID" value="ANT_25550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25550"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_0_0"/>
    <dbReference type="OMA" id="VPEQLHH"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="32223" checksum="F33D3D2CA8EAC61F" modified="2011-04-05" version="1">MIEKLPFGRTGHLSTRTLFGAAAFYNVTQEEADRTMEILMQYGVNHIDTAASYGDSEIRLGPWIEKYRHQFFLATKTGERTREKAREEIHRSLERLRTDHVDLIQLHAVIEDEELEQALGTGGALEAALEAREQGLVKFIGITSHSLHAPIIHLRALEHFDFDSVLLPCNFMLLQNPQYAEPFHKLLDLCRQKNVAVQCIKTLQRRPYGDGPHTHATWYQPFDEPEAVQMAVHWALGIPGVFINTVGDIHVLPLMLEAAANPQPAPSDDAMRALMARYEAAPLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN9</accession>
    <name>E8MZN9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_25610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560942.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64587">
        <property type="protein sequence ID" value="BAJ64587"/>
        <property type="gene ID" value="ANT_25610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25610"/>
    <dbReference type="eggNOG" id="COG4254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494915_0_0_0"/>
    <dbReference type="OrthoDB" id="1350635at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043724">
        <property type="entry name" value="DUF5666"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012373">
        <property type="entry name" value="Ferrdict_sens_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30273">
        <property type="entry name" value="PTHR30273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18914">
        <property type="entry name" value="DUF5666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="3">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5666" evidence="4">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5666" evidence="4">
        <location>
            <begin position="343"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="550" mass="60523" checksum="6E83225B38D85EA4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV6</accession>
    <name>E8MZV6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02570"/>
    <dbReference type="EnsemblBacteria" id="BAJ62291">
        <property type="protein sequence ID" value="BAJ62291"/>
        <property type="gene ID" value="ANT_02570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02570"/>
    <dbReference type="HOGENOM" id="CLU_155828_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="112" mass="12540" checksum="D15DE6779C1E5AFC" modified="2011-04-05" version="1">MYMILLVLDDPNLLDEVLQAWHDAGVFPLSVIESTGIHRRKKRVPMRYVFDEGVELEGHVTLYGIAPSLEKVQTCLKACEEITGDLDLPSTGVFAAWQIEAFHGLSEEDTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX9</accession>
    <name>E8MZX9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">engC</name>
        <name evidence="7" type="synonym">rsgA</name>
        <name evidence="10" type="ordered locus">ANT_02800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558711.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02800"/>
    <dbReference type="EnsemblBacteria" id="BAJ62314">
        <property type="protein sequence ID" value="BAJ62314"/>
        <property type="gene ID" value="ANT_02800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02800"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_2_1_0"/>
    <dbReference type="OMA" id="CLVAAYD"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04466">
        <property type="entry name" value="S1_YloQ_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="83"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="8">
        <location>
            <begin position="92"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="306" mass="33860" checksum="F0BE985974A4BFAF" modified="2011-04-05" version="1">MSDEASLIPGRVIRLQSGFYTVETPQGTWTCKLRGRFKLEQKDGDVISVGDCVQILPLSDGTGVIEVIEPRHSELVRMDPRPRGEYRQILLANIDQIVAVFACANPEPRLRMLDRFLVIAEKQGIPAVIIANKVDLVGMERARELFGMYPPLGYPVIYTSVRQGVGLDEVRECLRGKITGLAGPSGVGKSSLLNAIQPHLGLAVREVSEASGKGRHTTVVRQLFRLEMGGYVADLPGLRALALWDTQPEELDGYFPELRDRVAQCQFSDCTHTTEPGCAVLAALERGEIHPARYESYLRMRFGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY4</accession>
    <name>E8MZY4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_02850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558716.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02850"/>
    <dbReference type="EnsemblBacteria" id="BAJ62319">
        <property type="protein sequence ID" value="BAJ62319"/>
        <property type="gene ID" value="ANT_02850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02850"/>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_2_0"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="253"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="465" mass="51719" checksum="D31974E3B44C3521" modified="2011-04-05" version="1">MNIRILGAAQTVTGSQHLLEINGARVLLECGLFQGRRADTYTRNRTFPFNPRRLDAVILSHAHIDHSGNLPNLVKQGFEGPIYATPATAELAEIMVRDSAHIQEADAEYLNKKRLRRGEPPIEPLYTRADAEAVSPLFVPVPYNQPFEPAPGVHARFVDAGHILGSAGVILDLEENGTRRRVWFSGDIGREKLPLLKDPVLPENADYLLMECTYGDKPHRDPEAAYAEFREVALRTFERGGKVIIPAFAVGRTQEIVYSLNRMISDGDLPSVPVYVDSPLAVNASEVFMKHLELFDEETRQFIREHRHPALDFPTLTYIRDVEESKALNGLPGPMVIISASGMAETGRILHHLKNNLEDARNTVMIVSWQAPDTLGRRLADREFKVKIFGETYIRRAEVATIGGLSAHAGQDMLLKYALASRRSLRGITLVHGEELAAAALREKIIEAGFSKVEYPQSGTVLPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N014</accession>
    <name>E8N014_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62349">
        <property type="protein sequence ID" value="BAJ62349"/>
        <property type="gene ID" value="ANT_03150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03150"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_0"/>
    <dbReference type="OMA" id="KRYDVGN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="336" mass="37845" checksum="D47CFF8239953A53" modified="2011-04-05" version="1">MSKPTLKIAIPMAGLGTRMRPHTWSKPKPLVSLAGKTVLDYVLEQFSTIPPEFEVEYIFIVGPQGDQIREYMEEHHPQKTVHYVLQAEMRGQSHALYLAREYLNGPMLMAFSDTLVETDFSFLKENARDAIAWVKPVPDPRRFGVVELDEQGWVRRLIEKPSDMRNNLVIVGFYYFPSGEELIQAIEEQMHRNVLLKNEYFLADAVNILLERGTRMTTHQVEVWLDAGTPESLLETNRYLLDHGRDNSAEAARPGVTIVPPVFIHPSAHIEASVIGPHVSIGAECTLKRAIVSNSIIDEGSEIEDIAIEGSLLGRHVSLHGTPLHLNLGDQSWAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N075</accession>
    <name>E8N075_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/LC7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558807.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03760"/>
    <dbReference type="EnsemblBacteria" id="BAJ62410">
        <property type="protein sequence ID" value="BAJ62410"/>
        <property type="gene ID" value="ANT_03760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03760"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118613_1_2_0"/>
    <dbReference type="OMA" id="NVGRIRY"/>
    <dbReference type="OrthoDB" id="1736176at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="PTHR13323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="116" mass="12435" checksum="5291C9B447C7406E" modified="2011-04-05" version="1">MMVDRLRELQASSPDIEASAVVSVDGLTIASALPQGVEEDRVSAMSAAMLSLGERIANELGRGSLEQVYIKGEKGYVVLMSVGEEAVLTALAREQAKLGLIFLDMRRAAEDLTKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0C7</accession>
    <name>E8N0C7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561030.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64676">
        <property type="protein sequence ID" value="BAJ64676"/>
        <property type="gene ID" value="ANT_26500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26500"/>
    <dbReference type="eggNOG" id="ENOG502ZCY1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1092571_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="254" mass="28273" checksum="90B5C1F910ED304F" modified="2011-04-05" version="1">MSSQQKQAVLNRALFTQRSFDSSRIAVLSTLIHRFAEAGDYEVFVSRTHRTPLRLEVSVVDEDAPYQHNLDLATLQTPEKRDCCQGGKGLRLHAGGVLGFYTSQGVSTFQVRISRLGGKEKQVLLNHAEQIPAGDFFTVTPLLPGMYRVSDPVNKAEMILKVTMPPVPEQGKVEKGEKARGERRSPVYRPDQPVLITVGKKGFDRREASLFSGQTLVFQVQSAARLRVDLEKEDAGTTPPKKRPVKPPRPKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E2</accession>
    <name>E8N0E2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class I peptide chain release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561043.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64691">
        <property type="protein sequence ID" value="BAJ64691"/>
        <property type="gene ID" value="ANT_26650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26650"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_3_2_0"/>
    <dbReference type="OMA" id="SEHRSQW"/>
    <dbReference type="OrthoDB" id="2047548at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="132" mass="15119" checksum="20D1BA2E87C37D4B" modified="2011-04-05" version="1">MSIPPEEIRFTAIRASGPGGQNVNKVSTAVQLHFDVLRSKALPVDVKERLVKIAGKRVNEQGVLIIEARAYRTQEQNRADALRRLQELVEKARHVPKVRKKSQPSGGGRAREKRYISEKKRLRRLDLSEWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G1</accession>
    <name>E8N0G1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561062.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64710">
        <property type="protein sequence ID" value="BAJ64710"/>
        <property type="gene ID" value="ANT_26840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26840"/>
    <dbReference type="HOGENOM" id="CLU_1559776_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="19560" checksum="D2463DB81C65BA60" modified="2011-04-05" version="1">MQLPTHFVAGALIDKVVSRMRLPGWARVLTAGGLAYLFHGVLDKLAKATYHPPEPLDDPFWKGYHQRVLPVFTWATVLAFAPRHFFAMLCAALPDLDWVVRGISRRTGRTIPGWEKPVLNEGLHDLLNHVPVVKKLNHLPDWRYERKAVLVEAGLVVMMLSLLLWLMRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0K6</accession>
    <name>E8N0K6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_27290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27290"/>
    <dbReference type="EnsemblBacteria" id="BAJ64755">
        <property type="protein sequence ID" value="BAJ64755"/>
        <property type="gene ID" value="ANT_27290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27290"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105593_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="108"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="33994" checksum="D557DFE4AF2BAFAB" modified="2011-04-05" version="1">MTDPSSPKPKKLLDQLRDAIRLKHYSYSTEKTYVHWVRRYILYHNKRHPAEMGPAEIEAFLTHLAKEEQVSASTQNQAFSALLFLYRNVLQIDLPVPIHILRAKRSEHLPTVLSKDEVARVLSGMQGLHQLMGKLLYGCGLRLMECLRLRVKDIDFEQSQIIVREGKGEKDRVTMLPAWFSPSRNRSPMLRNFMNKIYATDSDRLNFLLRLPANTPMQIKNWAGNIFFHRKDYPSTHVVELCVVTIWTPAGCSGRSKLRRNWWESTSPSARTPSAIALPLTCSKQATTSGLFRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T2</accession>
    <name>E8N0T2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558873.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04430"/>
    <dbReference type="EnsemblBacteria" id="BAJ62477">
        <property type="protein sequence ID" value="BAJ62477"/>
        <property type="gene ID" value="ANT_04430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04430"/>
    <dbReference type="eggNOG" id="COG3870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143974_2_1_0"/>
    <dbReference type="OMA" id="KGYRMTE"/>
    <dbReference type="OrthoDB" id="2052224at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010375">
        <property type="entry name" value="CdAMP_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38456">
        <property type="entry name" value="PTHR38456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06153">
        <property type="entry name" value="CdAMP_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="88" mass="9802" checksum="40C820CD03B26CE9" modified="2011-04-05" version="1">MKLILAILRDIDHDAVSQALTSAGYRVTMIASTGGFWRRGNTTLMVGCEDEQVEPALQIIRNNCQTPAEPGTRHATIFVIKVDQYVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U4</accession>
    <name>E8N0U4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C26 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04550"/>
    <dbReference type="MEROPS" id="C26.961"/>
    <dbReference type="EnsemblBacteria" id="BAJ62489">
        <property type="protein sequence ID" value="BAJ62489"/>
        <property type="gene ID" value="ANT_04550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04550"/>
    <dbReference type="eggNOG" id="COG2071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030756_2_0_0"/>
    <dbReference type="OMA" id="PEYWAET"/>
    <dbReference type="OrthoDB" id="1628378at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="26947" checksum="A51814B59FF490E5" modified="2011-04-05" version="1">MEEEMTLPLIGITSIRKEGEPGQTHWYSTPFSYIHAVQRAGGMPVLIPPVYPAEKLPALLQRLDGVLLIGGGDIDPNLYGGEPHPRVYDIQAERDSLEITLVHLALETSTPLLGICRGAQVMNVALGGTLYSDIADQKPGALKHDYYPDFPRNTLAHAVEIEAQSRLAQMLGGTHFEVNSLHHQGISKVAPSLRVTAHAPDGLVEAVEVEGHPFAIGVQWHPEWLQEHAPQRALFSAFIRAASQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U7</accession>
    <name>E8N0U7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_04580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558888.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62492">
        <property type="protein sequence ID" value="BAJ62492"/>
        <property type="gene ID" value="ANT_04580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04580"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OMA" id="AFMGAWD"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="83"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="288" mass="32139" checksum="6CDA9F309172115A" modified="2011-04-05" version="1">MSALSSAVSQNRVPSLGWLKSGGKYTLLTLFALLWLLPVIAAVVTSFRTMDDITTHGFWSIPQTVTTQNFVKAWVNARVNKYLLNSFIITIPSLFGMLFLSSMGAYALARFKFKANLPLYFMFVAGTMLPFQILMLPVFRLTNALGLYDSYGALILIHTAFQLGFCTFVLRNFMRTVPGDILDAARVDGCSEFRIYWQIVLPLTLPALAALATLEFTWVFNDYLWAIILLRADTLRPVTAGLATLRGQYNTDWPVITAGALLATIPTLVVFVFLQRYFIQGLTLGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W2</accession>
    <name>E8N0W2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1858 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558903.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04730"/>
    <dbReference type="EnsemblBacteria" id="BAJ62507">
        <property type="protein sequence ID" value="BAJ62507"/>
        <property type="gene ID" value="ANT_04730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04730"/>
    <dbReference type="eggNOG" id="COG4309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507616_0_0_0"/>
    <dbReference type="OMA" id="PMPKVMA"/>
    <dbReference type="OrthoDB" id="1736609at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="175" mass="19897" checksum="C1AD247A5641C49C" modified="2011-04-05" version="1">MNITPQTRIGELLREYPALEEDLIRIAPAFKNLRNPVLRRTIGQLATLEKVAQIGNVTVLELVNTLRRAVGQPEMATLHDVPRNLKVSRLEEDPDWIQGEPQLVINGTELLQRGEVPLVQVNAVLPSLENGRYLLLISDFEPAPLLDALQKQGCRVHHRVNPEDTRQHWTFISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N133</accession>
    <name>E8N133_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64776">
        <property type="protein sequence ID" value="BAJ64776"/>
        <property type="gene ID" value="ANT_27500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27500"/>
    <dbReference type="HOGENOM" id="CLU_686322_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228041" evidence="1">
        <location>
            <begin position="26"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="401" mass="43993" checksum="0237EBE8C17CF86E" modified="2011-04-05" version="1">MRARWLGLFLCLGLMLGVGNLPAHAQMSTVLVLRSAPSSRYPQQGGVLTYTLWVENPASTGVIFRNPSFLLPEGTTLIAWGGFLSGSPQSTLENGRTRLLWQMTRTISAGTSLSANLWVQVDAAHRGGIFSGEWRVEEQTASGYLTVVQEEAAPVLFDAPAPLMEWQVSAVYAPVETEPPSLPLLPGEDSLWVQVTCLSAGQCLEVNLLQGGQTFSLTLQGEGKFEGNISPVSLRSPYHWEHNCVQAEILLEGGQRARRVLFCPYRHQPALRVMDTAHQPLASAQVEVYRLPGFAPGEGMGCPVSGWESLPPVDMDLRAIAEMENPLLSPARAEPPFFNPGFTVRDGTLSLQLERGCYYIRVVKNGCKEGFSPLYGAPPVWQDLPIILSCTRQVYLPFIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N137</accession>
    <name>E8N137_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hom</name>
        <name evidence="12" type="ordered locus">ANT_27540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561128.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64780">
        <property type="protein sequence ID" value="BAJ64780"/>
        <property type="gene ID" value="ANT_27540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27540"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_2_0"/>
    <dbReference type="OMA" id="YDLEGWD"/>
    <dbReference type="OrthoDB" id="1464088at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="11">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="10">
        <location>
            <begin position="159"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="36621" checksum="D7B8E45B63365223" modified="2011-04-05" version="1">MHVRLVLVGFGNVGRALARLLMRKRETLARDYGITFQVNGILTGRRGGCINPEGLDVERALSLVESGARLDELSTVPVPSTGVEFIRACPGDVLFENTPVNVVNGQPAIDHLRTALEQGMHAITANKGPVVHGYASLKALAERVGRRFLFESAVMDGAPIFSLFRGPLPAAELRGFRGILNSTTNLILELMENGKTFDEAVKITQDLGLAETDPSGDIDGWDASIKVAALSTVLMGVPLTPQDVDRTGIRGITPQMIAEARAAGERWKLVCTARREGDRVLGKVAPQRVSPDSPLYSISGSSSFVMFEMDVLPGLGIVESDPGPETTAYGLLADFINAMRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N152</accession>
    <name>E8N152_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64795">
        <property type="protein sequence ID" value="BAJ64795"/>
        <property type="gene ID" value="ANT_27690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27690"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_1_0"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="305" mass="33992" checksum="7BDECBB1E5A77820" modified="2011-04-05" version="1">MAESSLQGMSQSQKTLGESLSILIPAYNEALSIAGVLRGLLEQPELQGAEIIVINDGSTDETSQMVRQFPTVRLIEHLANRGYGTAIRSGARAAQRPFIVWYDADGQHRPQDLIALAQKLISEGLDYCIGVRMGDSYQDPERVVGKWLLRLAVNFAVGKPVPDFNSGLRGFKREVLLRYLPLLPKRFGASTLTTLLMIENEHFGGTIPIVTQPRIGKSTVRQFRDGLRTLQIILHIVILFKPLQFFGWMGSLLILAGLIYGFYKAFTVHLGFPVFGTLVILLGIQSFFFGLLCDQISALRRERWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N161</accession>
    <name>E8N161_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561152.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27780"/>
    <dbReference type="EnsemblBacteria" id="BAJ64804">
        <property type="protein sequence ID" value="BAJ64804"/>
        <property type="gene ID" value="ANT_27780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27780"/>
    <dbReference type="HOGENOM" id="CLU_2566373_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="81" mass="8681" checksum="BC376485B5EABE84" modified="2011-04-05" version="1">MNLRPSTLIALLLIFFLVGALIALASEGGNVNFRPISNPNVQTTLQPQGTPAPVNAEAAALGAPPSNFWENLRRWLGFAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N175</accession>
    <name>E8N175_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27920"/>
    <dbReference type="EnsemblBacteria" id="BAJ64818">
        <property type="protein sequence ID" value="BAJ64818"/>
        <property type="gene ID" value="ANT_27920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27920"/>
    <dbReference type="eggNOG" id="COG2921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161438_1_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007454">
        <property type="entry name" value="UPF0250"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027471">
        <property type="entry name" value="YbeD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38036">
        <property type="entry name" value="PTHR38036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04359">
        <property type="entry name" value="DUF493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117991">
        <property type="entry name" value="SSF117991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="89" mass="10319" checksum="9A64849E66ABA6B1" modified="2011-04-05" version="1">MMSLDREVFDFPTVIPLKVIGRNEQDFEAFVVSLFQKHLDEGDIQKVESRLSREDRYLSVTVSFTASSRVQLNAIYAELQSHQRVLMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1B9</accession>
    <name>E8N1B9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside kinase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_28360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561207.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28360"/>
    <dbReference type="EnsemblBacteria" id="BAJ64862">
        <property type="protein sequence ID" value="BAJ64862"/>
        <property type="gene ID" value="ANT_28360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28360"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_1_0"/>
    <dbReference type="OMA" id="EAMVMTP"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="4">
        <location>
            <begin position="5"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="25538" checksum="772D3ECA6AD734BC" modified="2011-04-05" version="1">MKRYITVAGNIGVGKSTLVKLLCAKLGWQPFYEPEARNPYLPDFYQNMAAWGFHSQVFFLANRLQIHRQIILFPGSVVQDRSVYEDAEIFAANLYRQGYLNERDYATYRALYQGIVEFLPPPDLVIYLRARPETLMERIAQRNREYERGISREYLEALNDLYEHWIETFTLCPVLTVPADHLNYVAHPRHLDLVVRKINEKLAGKEEVIFDPEEIAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S7</accession>
    <name>E8N1S7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Capsule polysaccharide biosynthesis family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559077.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62682">
        <property type="protein sequence ID" value="BAJ62682"/>
        <property type="gene ID" value="ANT_06480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06480"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507766_0_0_0"/>
    <dbReference type="OrthoDB" id="935597at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015774">
        <property type="term" value="P:polysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007833">
        <property type="entry name" value="Capsule_polysaccharide_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05159">
        <property type="entry name" value="Capsule_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="536" mass="61278" checksum="6B38D6BBFAD26103" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X6</accession>
    <name>E8N1X6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28970"/>
    <dbReference type="EnsemblBacteria" id="BAJ64923">
        <property type="protein sequence ID" value="BAJ64923"/>
        <property type="gene ID" value="ANT_28970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28970"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047405_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="227"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="406" mass="44328" checksum="04C154DF1C638EAB" modified="2011-04-05" version="1">MVAPQMSAHAILIAMEPRSLIHIRHLINTVGARPSCSPAVRHAATECARVLQACGAVETRLQSFQGVPETYLPFLWAFGAAALGSLLALLGSTAIFFALGAVLNALGVWAMLAESEFRSHWATPLIPRRETVNLITRFEPLETPRQTVVLCAHLDTHRTPVFYSTNAWLKAFGALVSGCFLSMALGALAFTVAALFGWAWMRWLALPLFLLQSFAAGMMLHALRTPHTPGANDNASGVGVILSTVERLMNQPLRHTRLYALLTDCEETGAWGMRAFLDRHADETGRDALYVILDQVGAGELRVLTRDGLIFKHPTHPQALQWARKAVQAQPVPYKEVIGTAYTDALPATLRGRIALTVCAIPPSGETTSARWHQMSDIPEALEAQALADAEAFTWTLLQVVDEEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N239</accession>
    <name>E8N239_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alkyl hydroperoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29600"/>
    <dbReference type="KEGG" id="atm:ANT_29600"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114041_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <keyword evidence="2" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="2">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="249" mass="27676" checksum="B12B332749A94E9B" modified="2011-04-05" version="1">MRLKVGDPAPDFTLPSHLGKEVALSSLRGRNVVLAFFPLAWTPIUTSQIPSYEAELDLFTGLNTQVLGISVDSVPCLKAWADSLGSISYPLLSDFYPHGRVAELYGVLRPDGTSERALFVVDRQGIIRYIDIHDINQQPDNEELRAILRQVDPQAAANEPRAKGEDAPLPSGGIIMYCTPWCDDCKQARQWLMQRGFKFAEVDISRNRKAAEQVRRWANGNLTTPTFDINGTIIVDFQPDKLAEVLGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N244</accession>
    <name>E8N244_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative competence protein ComEC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">comEC</name>
        <name evidence="9" type="ordered locus">ANT_29650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561335.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64991">
        <property type="protein sequence ID" value="BAJ64991"/>
        <property type="gene ID" value="ANT_29650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29650"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371993_0_0_0"/>
    <dbReference type="OMA" id="SGWNITI"/>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4131" evidence="8">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="231"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="747" mass="79929" checksum="EF7B447959CC06E0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8N268</accession>
    <name>E8N268_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lysS</name>
        <name evidence="9" type="ordered locus">ANT_29890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561359.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29890"/>
    <dbReference type="EnsemblBacteria" id="BAJ65015">
        <property type="protein sequence ID" value="BAJ65015"/>
        <property type="gene ID" value="ANT_29890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29890"/>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_0"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="183"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ65015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="511" mass="58742" checksum="ACE8ADE0958C5493" modified="2011-04-05" version="1">MNFSELERIRVEKIERMRARGIEPYPTRAEVSHTTVQAIQLYEQAESAGSSDPVQVSVGGRLRAIRTMGKVTFAHIEDGWGRLQLFFRVNELGEAEMERFRDDFDLGDFIQASGVMFRTRSGEITLHVHAFKMLSKAITPLPAAKDEVVDGKVIRHAALTDPETRYRQRYADLAVNPEVREVFRIRARAVKALRDYLDNMGFLEVETPILQPIYGGAAARPFVTYHNQLKQNLYLRISFELYLKRLLVGMLDRVYEIGRDFRNEGVSYKHNPEFTQLEFYMAYADYLQVMEITEQMVAYVAQQVLGTTTITYEGHTIDLTPPWRRLELRQGILETTGIDIDQHPTAESLAEAMRAKGMQPKPGYSRGKLIDSLLGDYLEPTLIQPTFLYNYPRDISPLAKSMPGNPLITERFEGYIGGMELCNAFTELNDPLDQEQRFLEMGRDYNADDEERHPMDEDYLRAMSYGMPPCGGFGMGIDRLVMLLADRHTIREVILFPHLREEDRPGEKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D1</accession>
    <name>E8N2D1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559131.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07030"/>
    <dbReference type="EnsemblBacteria" id="BAJ62737">
        <property type="protein sequence ID" value="BAJ62737"/>
        <property type="gene ID" value="ANT_07030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07030"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_2_1_0"/>
    <dbReference type="OMA" id="VIPVWFE"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="140" mass="16419" checksum="ED380F9AD66191A8" modified="2011-04-05" version="1">MAEFRFSIPLETRYGDLDPQWHLNNARFLTFFEHARMAYLVHLGLWDGKDFFKLGLIVADVHVSYLAPVEIFHKCRVDLRVARLGNKSMTFEYRLVDEDDGTLYATAETVMVSYDYYTRKSIPIPAEWREKIKAFEGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G5</accession>
    <name>E8N2G5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_07370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559164.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07370"/>
    <dbReference type="EnsemblBacteria" id="BAJ62771">
        <property type="protein sequence ID" value="BAJ62771"/>
        <property type="gene ID" value="ANT_07370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07370"/>
    <dbReference type="eggNOG" id="COG1814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_3_0_0"/>
    <dbReference type="OMA" id="SRIGWLR"/>
    <dbReference type="OrthoDB" id="1717935at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="229" mass="23330" checksum="F327AFFA277790FB" modified="2011-04-05" version="1">MPHREYHYTDRIGWIRAAVLGANDGIVSIASLLMGVAAAGTGHSGILIAGVAGLVAGAMSMAAGEYVSVSSQSDTEKADLARERAELAADPAAELEELTQIYVQRGLDEVLARQVAMQLSERNAFEAHARDELGMSEVTVARPVQAALTSALAFSAGGILPVLSAVMAPVSIAPLVIPLVSLIVLASLGALSASLGGAPVGKSVLRVTFWGAIAMAITAGIGKLFGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H1</accession>
    <name>E8N2H1_ANATU</name>
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        <submittedName>
            <fullName evidence="4">Peptidase M23 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_07430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559170.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07430"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="BAJ62777">
        <property type="protein sequence ID" value="BAJ62777"/>
        <property type="gene ID" value="ANT_07430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07430"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_3_0"/>
    <dbReference type="OMA" id="PETIMIN"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="403" mass="44083" checksum="E1624D6C6EE5DFE8" modified="2011-04-05" version="1">MTEDSHLPSPLSSEIEEAGEARLAAEEQRPASRWSTIWEHILRLGLGEIALRAGTLIVSIALILLVIWVMARFYLKGNVESAQQSVLAAPLPSPTPTVQIPAFKPVTVSVSSGIPRLARLDTYVPSRPRFEITTYEVQKGDTVFGIAEKFGLKPQSILWGNFETLADDPHRLQIGMKLNILPVDGVLYRWHEGDSLLKVAEFYGVTPETIIDWPGNHLDAAKLGDLSKPNIEPGTLVFVPGGKRDFISWSAPFISRRDPAKAKIFGPGYCGTQVDGYIGNGSFVWPTTERWLSGYDYSPETNHWGIDIAGRIGNPIYAADSGVVVYSGWNENGYGYVVVIDHGNGWQTLYAHLSQIYAGCGASVSQGDTIGAMGSTGRSTGPHLHFEIMSESGVRVNPWSFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L6</accession>
    <name>E8N2L6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559215.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07880"/>
    <dbReference type="EnsemblBacteria" id="BAJ62822">
        <property type="protein sequence ID" value="BAJ62822"/>
        <property type="gene ID" value="ANT_07880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07880"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058789_0_0_0"/>
    <dbReference type="OMA" id="YLGIWLQ"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="154"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="31852" checksum="A2FDA67A9A09D4F4" modified="2011-04-05" version="1">MGEIAALLTSVLWAFSSIIHTFAGRRVGPGVLNRARLLFAVMWILLTHRIFQGTFFPVHAAPERWFWLGLSGVVGLVLGDWFLFYAYVTIGARMGTLIMASVPMLSAMLAWIFLGETLTLTEILGMILVVSGIAMVILDRVNGNISLPRRTYWLGVLAGFGGALGQAGNLILAKPGLADGFPSISGVAIRMVTAAVVLWGLTFLKKEARPTLEALKDRRALGLILLGSMIGPFAGVWLSMVAIQNTLVGIASTLMALSPVILLPLSRWFFHETISWRAIIGTLICMAGTAALFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T6</accession>
    <name>E8N2T6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561427.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30600"/>
    <dbReference type="TCDB" id="9.B.2.3.2">
        <property type="family name" value="the integral membrane caax protease-2 (caax protease2) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65086">
        <property type="protein sequence ID" value="BAJ65086"/>
        <property type="gene ID" value="ANT_30600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30600"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_4_0_0"/>
    <dbReference type="OMA" id="LITIGCM"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="30921" checksum="6607E07E88163A61" modified="2011-04-05" version="1">MKAENRDFPLLFFLLTLGFSWLFWTPLALQAHGWLTLPAPLADFLAGAFNPAPWMPSLMGILLTLIYEGWQGLTAWLKNGLNPRRLGRAGWLMTIFLPLGIFLGAHLIEALIRQHPPDLSVLSNPPLALFAPLVILFTSGPLQEEFGWRGFALPRLLRRFNALTASVWLGFFWWLWHLPLVFIPGKFMVSTLTLFLLLLVEIVLTAVLMTWVYRRTQHSILAALVFHTVMNYSIWVLLPSMQVSAGLILITCALLALAVAGLVLREERQQSQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U0</accession>
    <name>E8N2U0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30640"/>
    <dbReference type="EnsemblBacteria" id="BAJ65090">
        <property type="protein sequence ID" value="BAJ65090"/>
        <property type="gene ID" value="ANT_30640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30640"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084517_1_1_0"/>
    <dbReference type="OMA" id="FVWASEV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="193" mass="21960" checksum="25281B3042FFEF2C" modified="2011-04-05" version="1">MYTPLPFPIDSLHPVDWLFAALSFAAERHRDQRRKGVLHAPYINHLIEVAHLLWAVGGVRDPEVLAAAVLHDVLEDTPTSPEEINRLFGARVRALVQEVSDDKSLPQAERKRLQEEHAPCLTADAKLIKLADKISNVRSILEDPPEQWSDARRREYVAWAVRVVAGMRGVNPALEDEFDRMVARAREIWQDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W2</accession>
    <name>E8N2W2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561453.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30860"/>
    <dbReference type="EnsemblBacteria" id="BAJ65112">
        <property type="protein sequence ID" value="BAJ65112"/>
        <property type="gene ID" value="ANT_30860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30860"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_0_0"/>
    <dbReference type="OMA" id="GASPMEF"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="49"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="241" mass="27234" checksum="F2CD6F2F651FC3CD" modified="2011-04-05" version="1">MQQSLSHTKTNRKPWMDRQKLQKIFDVLIHALTRPEFHGVEHVPAEGGVILATNHMSRMDTLLLFINPARKDVTALVADKYQKYPLFAWILRTGGIIWLDRENADFGALRAAVEVLKKGVALGIAPEGTRSRTGQLLEGKPGTALVALRAGVPIVPTAIAGTENVFPRIFTLQRPRISVTFGKPFVLPPLDRDRREEQMKRYTEEIMCRIAALLPEKYHGFYRGHPRIREIQQGINLDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X3</accession>
    <name>E8N2X3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class-I fumarase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30970"/>
    <dbReference type="EnsemblBacteria" id="BAJ65123">
        <property type="protein sequence ID" value="BAJ65123"/>
        <property type="gene ID" value="ANT_30970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30970"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098588_0_0_0"/>
    <dbReference type="OrthoDB" id="1627779at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="209" mass="22761" checksum="E209B1DB07F1C1EC" modified="2011-04-05" version="1">MKKVQIPISDDVVRSLKVGDPLALSGVMVTARDAGHKWLIDTFVTRKREPQGDDLEVYEALKKLLNGGVIYHCGPVVAGLDTREYRFVAAGPTTSIREEPYQGDIMRHFNVKGVIGKGGMGAKTLQACQEVPGLYLHAVGGAATWIAQTVKRVLGVYKLEFGVPEAFWVIEVEDFPVVVTMDANGNSLHAEIEARSAKVLENLLTGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N323</accession>
    <name>E8N323_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561514.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31470"/>
    <dbReference type="EnsemblBacteria" id="BAJ65173">
        <property type="protein sequence ID" value="BAJ65173"/>
        <property type="gene ID" value="ANT_31470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31470"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062593_0_0_0"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="30928" checksum="18D597D6334D5A8B" modified="2011-04-05" version="1">MKRNYQENFFTLYTSFQSHDRRLEKGRKIHYTLTQFCKGGLQTKTCLDVGCSAGVITSYLRPLFNKMIGLDYDPVGMGLITPEQKKEVGFTRGDAMNLPFEDESVDVVICAQVYEHVPDDQRLFQEIERVLKPSGIVFFSGPNKLFPIELHHNLPFLQWLPPKWANRYVKLLGKGNEFYEYSRTLGDLRKVLSGFDVYDVTVPVLRFFVHERQGIKRLLYQIFAHAPRWIKHLVAWLTPNFNWILVKKNDSSVPSRYTLVETLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A7</accession>
    <name>E8N3A7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-galactoside ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559313.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08870"/>
    <dbReference type="EnsemblBacteria" id="BAJ62921">
        <property type="protein sequence ID" value="BAJ62921"/>
        <property type="gene ID" value="ANT_08870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08870"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_2_0"/>
    <dbReference type="OMA" id="SECLTRT"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228643" evidence="1">
        <location>
            <begin position="26"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="180"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="723" mass="82371" checksum="E8B45AD3D9BF424D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G9</accession>
    <name>E8N3G9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559374.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09490"/>
    <dbReference type="EnsemblBacteria" id="BAJ62983">
        <property type="protein sequence ID" value="BAJ62983"/>
        <property type="gene ID" value="ANT_09490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09490"/>
    <dbReference type="eggNOG" id="COG3296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104196_1_1_0"/>
    <dbReference type="OrthoDB" id="2012653at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="141" mass="15291" checksum="011707C0B13D8F3B" modified="2011-04-05" version="1">MTEQTNVVIPTSSEERTWAMLAHLSVLINLVTGLLGPVVALVIYLSYKDRSRYVAYHALQSLVLQLVAWVGFGAVTGIMWGIVGALSAILIGLCLIPFACAVTLVPLAVPVYGIVAAIETSQGRDFRYWLIGDWVRSTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I5</accession>
    <name>E8N3I5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HoxW protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hoxW</name>
        <name evidence="2" type="ordered locus">ANT_09650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559390.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09650"/>
    <dbReference type="EnsemblBacteria" id="BAJ62999">
        <property type="protein sequence ID" value="BAJ62999"/>
        <property type="gene ID" value="ANT_09650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09650"/>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099037_6_1_0"/>
    <dbReference type="OrthoDB" id="1858718at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="169" mass="19088" checksum="55294EC5DD704765" modified="2011-04-05" version="1">MKTLVIGYGNIDRQDDGVAWHFLRALAEHLGYTLPEYPEENPVLSTPALDMHFYLQLMPEMAEWMADFSRIVFVDAHTGSVPEEIHLEEVQPVFQSSPLTHHLTPAACLSLVYALYGQQPRAVLLSLRGYAFGFDRTLSPQTDSLLSKALQVLETWLHQTAEDNSFSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I8</accession>
    <name>E8N3I8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative oxidoreductase</fullName>
            <ecNumber evidence="13">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ANT_09680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63002">
        <property type="protein sequence ID" value="BAJ63002"/>
        <property type="gene ID" value="ANT_09680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09680"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_0"/>
    <dbReference type="OMA" id="RTIEIMI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="12">
        <location>
            <begin position="113"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="254"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="680" mass="73374" checksum="B83621D3D510AD47" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K7</accession>
    <name>E8N3K7_ANATU</name>
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        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559412.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63021">
        <property type="protein sequence ID" value="BAJ63021"/>
        <property type="gene ID" value="ANT_09870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09870"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428759_0_0_0"/>
    <dbReference type="OMA" id="HYWGGPK"/>
    <dbReference type="OrthoDB" id="150903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
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        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_7TM" evidence="2">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="638" mass="72081" checksum="6D05F12A1EA4D248" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M7</accession>
    <name>E8N3M7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplB</name>
        <name evidence="7" type="ordered locus">ANT_10070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="BAJ63041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63041">
        <property type="protein sequence ID" value="BAJ63041"/>
        <property type="gene ID" value="ANT_10070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10070"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_0"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="30168" checksum="E116F23A51B8FEB6" modified="2011-04-05" version="1">MAVKVYKPVTPGLRGMTGYTFEEITKTKPERSLIVVRKKHAGRNHFGRVTVRHQGGGNRQFIRLVDFKRDKRGIPARVAAIEYDPNRTARIALLVYADGEKRYIVAPLGLKVGDTVLAGKDAEIRPGNSLPIANIPVGTMIHNIELKEGRGGQLVRAAGAAAQLLAKEGDYAQVRLPSGEVRLVRQTCYATIGQVGNLDHSNVKLGKAGRKRHMGIRPTVRGTAMSPRDHPHGGGEGRQPVGMPGPKSPWGKPTRGYKTRRNKQTDKYIVRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N5</accession>
    <name>E8N3N5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rplX</name>
        <name evidence="3" type="ordered locus">ANT_10150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559440.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63049">
        <property type="protein sequence ID" value="BAJ63049"/>
        <property type="gene ID" value="ANT_10150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10150"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_0_0"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="110" mass="12218" checksum="334D0BAECE154CA7" modified="2011-04-05" version="1">MKVKIHKGDTVEVISGRREDKGKRGEVIRVLPDEGRVVVQGVNLRTKHQRQVQAQGRTINPGLVKFEAPIHISNVMLVCPKCGKATRVGINRQAEKAVRVCKKCQAVIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P8</accession>
    <name>E8N3P8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsM</name>
        <name evidence="8" type="ordered locus">ANT_10280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559453.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10280"/>
    <dbReference type="EnsemblBacteria" id="BAJ63062">
        <property type="protein sequence ID" value="BAJ63062"/>
        <property type="gene ID" value="ANT_10280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10280"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_0"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="128" mass="14712" checksum="4322ABE9356B995C" modified="2011-04-05" version="1">MARIEGVDLPRNKRVEVALTYIYGIGPTRARETLAATKVNPDTRVKDLTEAEVNALRDYIARNYTVEGDLRREVQMSIKRLIEIGCYRGLRHRRNLPVRGQRTRTNARTRKGPRKTVAGRGRRRGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Q7</accession>
    <name>E8N3Q7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_10370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559461.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63071">
        <property type="protein sequence ID" value="BAJ63071"/>
        <property type="gene ID" value="ANT_10370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10370"/>
    <dbReference type="eggNOG" id="COG3439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126998_1_1_0"/>
    <dbReference type="OrthoDB" id="1819840at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="2">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="154" mass="17475" checksum="68E0308C2187776F" modified="2011-04-05" version="1">MTPENPFEVVLFLSYPQALEIVSRVLKEEGFGVVTHIDVSATLKKKMNVDFRPYSILGAYNPPIVHRALQHDPRIGLMLPCNISVESLGDRVVVRFADPLEIVSCNALEDNIAREIAEEIQQVLLRVAQRLREGNYTPNDPEKGWKRLHSETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W2</accession>
    <name>E8N3W2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559516.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10920"/>
    <dbReference type="EnsemblBacteria" id="BAJ63126">
        <property type="protein sequence ID" value="BAJ63126"/>
        <property type="gene ID" value="ANT_10920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10920"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_5_0_0"/>
    <dbReference type="OMA" id="YAYLDDW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="273" mass="30666" checksum="A5BFD1827DE1B1F7" modified="2011-04-05" version="1">MTNIWRLLISPPARGAWNMAVDEALMEFCARGESHPVLRLYAWEPPCLSLGQAQPVGDVHRTRLAEKGWNLVRRPTGGRAILHTDELTYAVIAPATHEIMSGGLLESYMRISRFLLKALDHLAVPAVSQKEYPLPEGANPKGPVCFEVPSNYEITVNGKKLIGSAQFRRKESVLQHGSLPLYGDLTRITLALNHTDEEQRQQSATRLLERAITLEQALGRIVTWQEAADAFIQAFAETFGVTWEIRPLTSHELARVAQLEKEKYAHPSWTERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N414</accession>
    <name>E8N414_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_11440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11440"/>
    <dbReference type="EnsemblBacteria" id="BAJ63178">
        <property type="protein sequence ID" value="BAJ63178"/>
        <property type="gene ID" value="ANT_11440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11440"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OMA" id="MITFVHA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="32543" checksum="7D733A5953C9257F" modified="2011-04-05" version="1">MKNGTEKYSPLNRYRVKKFLNRTGLYILLCTITLLIIIPLVWMFSTSFKLKSQLFTKEIYWIPKVITLQNYTKILNNPSTPIGRWFLNSLIVASITTTLKLLIDSLAGYAYARMDFPGKKQIFGLLLATLFLPGVMFLVPNFVTVAKLNMLNKFSGVIIPSLASVFGVYFMRQFFMSIPKELEEAAQIDGANTVQIFIQIALPLAKPALATLAVIEFLGSWNDFLWSLLVLKDRAVQTLQPGLRTLQGAYTSEYGLMMAGAVIVAIPVLIIYVFMQRFIVQSVATTGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N457</accession>
    <name>E8N457_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_11870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63221">
        <property type="protein sequence ID" value="BAJ63221"/>
        <property type="gene ID" value="ANT_11870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11870"/>
    <dbReference type="HOGENOM" id="CLU_1631949_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="162" mass="18848" checksum="EB56183C4136F9E4" modified="2011-04-05" version="1">MMDFHWHLQWLELYLALSEYTFDLAQHSEFPSIREILNQLKEGNLEAFLLILQHPDERVRVHGVYTLQAFLEGCLPLQRLGYLKAFHSVPPLRYLPAFQDLQKQWEGEKKSATRSQAVKTPFSSTCRELPRSAGCICWMSIESFWILSLLPYFPGAKGEPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N475</accession>
    <name>E8N475_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559627.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63239">
        <property type="protein sequence ID" value="BAJ63239"/>
        <property type="gene ID" value="ANT_12050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12050"/>
    <dbReference type="eggNOG" id="COG3634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082677_0_0_0"/>
    <dbReference type="OMA" id="RMAHKFA"/>
    <dbReference type="OrthoDB" id="1300544at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="Glutaredoxin-like_bact/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02187">
        <property type="entry name" value="GlrX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="224" mass="25337" checksum="446E87BB69CF944F" modified="2011-04-05" version="1">MEKMLDENIRQQVREFFEALEKPVQILFFGADDKSVCQYCEETRQLLSEVCELSDKLELKVYDLNENRELAAQYKVDAVPTFVILGKDGDTLTDYGIRYKGIPAGHEFTSLVNSILIVSRRDSGLSKETREFLKTLDKPVHLQVFVTPTCPYCPRAVVLAHQMALESPMVEAEMVEAMEFPELSDQYGVSGVPHTTINFGAEHMVGAAPEHMLIDHIQRALARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C9</accession>
    <name>E8N4C9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocating P-type ATPase</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_12590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559681.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12590"/>
    <dbReference type="EnsemblBacteria" id="BAJ63293">
        <property type="protein sequence ID" value="BAJ63293"/>
        <property type="gene ID" value="ANT_12590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12590"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_0"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="808" mass="86442" checksum="88C35BCBE51F7C70" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F1</accession>
    <name>E8N4F1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63315">
        <property type="protein sequence ID" value="BAJ63315"/>
        <property type="gene ID" value="ANT_12810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12810"/>
    <dbReference type="HOGENOM" id="CLU_3339284_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="37" mass="4426" checksum="A6D2480F388CF5DB" modified="2011-04-05" version="1">MKTVSNLKKHLKFEIFSVIVEISHLPVVPLYWQVRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4P7</accession>
    <name>E8N4P7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559795.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13830"/>
    <dbReference type="EnsemblBacteria" id="BAJ63411">
        <property type="protein sequence ID" value="BAJ63411"/>
        <property type="gene ID" value="ANT_13830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13830"/>
    <dbReference type="eggNOG" id="COG2738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084406_0_0_0"/>
    <dbReference type="OMA" id="VQHATAY"/>
    <dbReference type="OrthoDB" id="1656873at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="232" mass="25080" checksum="6A649C4BD63FA913" modified="2011-04-05" version="1">MGAYGGGYLLYLLFSLPALLLGFWAQFKVQSAFNTYSRKRNASGMTGAEVARRILNMNGLTNVQVEAVNGFLSDHYDPVARVLRLSPEVYHSNSIAAAGIAAHEAGHAIQHHEGYFPLQIRSAIVPAVQIGSWLGPIIFMLGFFLMGNTVAWIGLGLFAATAVFALITLPVEFDASRRAKTVLADGGLVYYGEMEGVNKVLDAAALTYVAAAVQAISTVLYYIFLLSGRQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R7</accession>
    <name>E8N4R7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fusA</name>
        <name evidence="5" type="ordered locus">ANT_14030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559813.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63431">
        <property type="protein sequence ID" value="BAJ63431"/>
        <property type="gene ID" value="ANT_14030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14030"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_0"/>
    <dbReference type="OMA" id="DRGHEDH"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="7"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="687" mass="75112" checksum="445D9D2B39095042" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S6</accession>
    <name>E8N4S6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_14120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559822.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63440">
        <property type="protein sequence ID" value="BAJ63440"/>
        <property type="gene ID" value="ANT_14120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14120"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025379_1_0_0"/>
    <dbReference type="OMA" id="APTHIRQ"/>
    <dbReference type="OrthoDB" id="1698335at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="237"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="412" mass="45715" checksum="D0A0D1963E871B3B" modified="2011-04-05" version="1">MSFSLKQILGLSEPFPEEHRENFIHLFFDIAWWGVLNGSIIVFLAVYASRLGASSFQIGILTASPALMNILMTFPTNFFVRGKSTFQVVRWSALFTRLFYAFLIPLPILFPAQVQIWTIIVITLIMNIPGTIAAVMGNAFLAEGIPMEWRGQIIGIRNALLALTSMITSFIVGQVLKVFPFETGYMIVFGLGWLGSMLSAYHLFKVKVVAPQTSPQSSQAQKPSWREIIRPDVLSGSFRNVLLVMFFFHVAVFLPNPIFPLYQVNELKLTDETIGFGTSLFWILYFLTSTQVGGLSRKYGFKTLTGAGTIIASFATLIFTFSYQVWIYVITQIVSGIGWAIIGGGLVNYVLVNVPPDDRPSYLAWFNLAVNFAVLICGLVAPLITANLGLFGSMVLAVLVRFLAGIAILRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U5</accession>
    <name>E8N4U5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559841.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63459">
        <property type="protein sequence ID" value="BAJ63459"/>
        <property type="gene ID" value="ANT_14310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14310"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068832_0_0_0"/>
    <dbReference type="OMA" id="HIHISGI"/>
    <dbReference type="OrthoDB" id="1088517at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="31396" checksum="00FDB8E061DE47D5" modified="2011-04-05" version="1">MIPFMFGTVGAPLSTPKKPGGSVGAIQHLASLGLYAFELGWVQSVRVSEETCHAIREAAKAYNVQISVHAPYFINLNADDNEWQKSRKRLMDAAYYGALAGATDIIFHPGSYFSMPPSEVLPKAIKRLEGCVRELQEMGTRVTLRPETMGKSAMLGSLEDVLEMSKALPEYVQPCLDFAHLHARTGTGALNTREEWLRVLDQVAETLGADALQSLHIHLSGIEYSEKGEKNHLKLEESDLNLKGLFTALYEKKCTGRILCESPVLEEDALLMKQRWIEWFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y1</accession>
    <name>E8N4Y1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="9">1.2.7.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_14670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559877.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63495">
        <property type="protein sequence ID" value="BAJ63495"/>
        <property type="gene ID" value="ANT_14670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14670"/>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_0"/>
    <dbReference type="OMA" id="GRGCEFA"/>
    <dbReference type="OrthoDB" id="332680at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="610" mass="66132" checksum="64AA00A81449BFD1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N558</accession>
    <name>E8N558_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">purH</name>
        <name evidence="10" type="ordered locus">ANT_15440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559954.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15440"/>
    <dbReference type="EnsemblBacteria" id="BAJ63572">
        <property type="protein sequence ID" value="BAJ63572"/>
        <property type="gene ID" value="ANT_15440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15440"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_0"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="501" mass="55006" checksum="DB76F353BC169984" modified="2011-04-05" version="1">MPNALISVTDKSQLVEFAQELVTLGWVIWASGGTSNELRKNSITVNELSDYTGMGEMLGGRVKTLHPAIYAGILARDIHEDEKVLANNNWLRFDLVVVNLYPFEKKVQSPNIDLSEAIENIDIGGVALLRAAAKNFQRVLVVCDPADYSVVIDALKSGQNTETLRRSLAWKAFGVTSRYDAFIAGFLSSGEVYPLNLYRCQNLRYGENPHQQAIFYSFSPNEKPFDGRVLQGKELSYNNILDVDAGWRVVSSFDEPTVAIIKHLSPCGIASANTVAEAYRQALECDPVSAFGGIVASNRVIDETAAIQMKDLFIECIVSPGFTSEAMEILSRKKNCRVIEIPISTQYSNEQWELRSVYHGVLRQSVDWGDPHGTEWRVVTSKHPDQEQMVALKFAWKACQHVKSNAIVLAKGKSTVGIGGGQPNRVQSVRIAIENAGERARGAVMASDAFFPFPDSIEVAAKAGIGAIIQPGGSVRDNDVIRAADNSGIAMIFTGVRHFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N570</accession>
    <name>E8N570_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thrC</name>
        <name evidence="4" type="ordered locus">ANT_15560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559966.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15560"/>
    <dbReference type="EnsemblBacteria" id="BAJ63584">
        <property type="protein sequence ID" value="BAJ63584"/>
        <property type="gene ID" value="ANT_15560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15560"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_0_0"/>
    <dbReference type="OMA" id="GFTNKAM"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="65"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="372" mass="40802" checksum="9EE35D8E34DC624D" modified="2011-04-05" version="1">MNSFLRCLSCHAVYAINEPIWKCACGGLLDIEVDFSRTKQWEIVKFPGLWKYLPFIPLPDKSIIITLGEGQTPIIRYLYKNQEILIKQEQLFPTGSYKDRGAAVMISAIRAMGIRSVVEDSSGNAGCSVAAYCAKAGIDCSIYVPASTSPAKLMQISAYGARVVKVEGTREDTARMVLSAASQNYYASHSWNPFFFQGTKTFAYEVWEQTEGKLPDAIILPVGNGTLFLGVYKGFHDLLSMGLIEKIPRMVGVQASLCAPLSHWEKLDLGGIPIDVNTIAEGIAIQKPVRGAQIIEALHQTHGMILEVEEDEIEMALRLAVEQGFFVEPTGVVGLAGTIQYLKRFPEVGKVLTAFTGHGLKSPEKILSVLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E4</accession>
    <name>E8N5E4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560038.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63658">
        <property type="protein sequence ID" value="BAJ63658"/>
        <property type="gene ID" value="ANT_16320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16320"/>
    <dbReference type="eggNOG" id="COG1168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_0"/>
    <dbReference type="OMA" id="RINIGCP"/>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="42"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="383" mass="43242" checksum="1D996F582FCE6983" modified="2011-04-05" version="1">MKYDFDTVIPRQNTDSEKWSFYPKDVLPMWVADMDFRSPEPVIEALRARVEHGVFGYPNQATVLKDLLVERMAHRYSWKITPEDIILLPGVVPGINIACHAFAHHKGVVVQPPVYGPFLTAPQNAKAIRLDAPLVQNNLGEYEIDWDILKTACSKDANLMIFCSPHNPVGRVWKREELEKMGELCLRHRVVLCSDEIHCDLVYPGHAHIPIASLSPELAHNTITLMAPSKTFNLPGLFCSFAIIQNPQLREEFLNARQGLVGGVNIMGITASVAAYQSGEEWLTQLLDYLQGNRDFLYNILQAEFPELKMSKPEGTYLAWIDCRNLPETFSNPSKFFLEKAKVGVVDGKWFGKEGEGFVRLNFGCPRSILNEALERMKLALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S5</accession>
    <name>E8N5S5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560167.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17630"/>
    <dbReference type="EnsemblBacteria" id="BAJ63789">
        <property type="protein sequence ID" value="BAJ63789"/>
        <property type="gene ID" value="ANT_17630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17630"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_0"/>
    <dbReference type="OMA" id="RMWLRDP"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="1">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="334" mass="37286" checksum="0C3F5C1A60F4308F" modified="2011-04-05" version="1">MNLVTGATGHLGNVLVRELVSRSEPVRALVLPGEDLRSLEGLPIEIVEGNVLDLPSLISACQGVDTVFHLAGLVSILEEHEPILRKVNVEGTRNVIQAVLQTGVRRLVYTSSIHALTRPPHGVLIQEDLPFDPQNPAGAYDRTKAEASILVLEAVQRDGLDAVIVCPTGVIGPYDYRRSEVGEMILNWMTSRLDYIVKGGFDFVDVRDVARGHILARDYGIKGHTYILGGEQISVTQLRALVKEIRGLFAPALEFPKAIAFWFASLAEIYYKVTHTRPKFTRYSIETLLSNSQISIQRAKTELGYAPRKLSETLRDTIAWWLEHFRKTRKSVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U2</accession>
    <name>E8N5U2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NAD-reducing hydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ANT_17800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560184.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17800"/>
    <dbReference type="EnsemblBacteria" id="BAJ63806">
        <property type="protein sequence ID" value="BAJ63806"/>
        <property type="gene ID" value="ANT_17800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17800"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_0"/>
    <dbReference type="OMA" id="DRMLMEG"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="594" mass="65209" checksum="57E2D99EB0DBCBB8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z5</accession>
    <name>E8N5Z5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mog</name>
        <name evidence="4" type="ordered locus">ANT_18330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560236.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63859">
        <property type="protein sequence ID" value="BAJ63859"/>
        <property type="gene ID" value="ANT_18330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18330"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_1_1_0"/>
    <dbReference type="OMA" id="TGWDGIL"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="18516" checksum="817A0533572087A1" modified="2011-04-05" version="1">MGNPSIRVSILTVSDRSFRGEREDLSGPALIQAIQQLGWEIVQTGLAPDEKESISAWLIQVCDSGTTDLILTTGGTGFAPRDVTPEATRAVIEREAPGLAEAMRQKSLQITPHAMLSRAIAGIRKRTLIVNLPGSPKAAVENLQSIAVVIPHAVELLQESPSAEVGHYHPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N605</accession>
    <name>E8N605_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein ANT_18430</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560246.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63869">
        <property type="protein sequence ID" value="BAJ63869"/>
        <property type="gene ID" value="ANT_18430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18430"/>
    <dbReference type="eggNOG" id="COG1872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_6_0_0"/>
    <dbReference type="OMA" id="AANRECC"/>
    <dbReference type="OrthoDB" id="1997369at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005228">
        <property type="entry name" value="CHP00251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00251">
        <property type="entry name" value="TIGR00251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="105" mass="11566" checksum="4084D6007A7D816B" modified="2011-04-05" version="1">MSREKREFRLHDGKTGAAITVRVTPRASKNEIYEILDDGTVKIRLTAPPVEGKANEALIDFLSEVLDVPRTSLEIVAGETGRDKIVTVLNLDASTVQARILQHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N632</accession>
    <name>E8N632_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560273.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63896">
        <property type="protein sequence ID" value="BAJ63896"/>
        <property type="gene ID" value="ANT_18700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18700"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290472_0_0_0"/>
    <dbReference type="OMA" id="YEACNDQ"/>
    <dbReference type="OrthoDB" id="105303at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1053" mass="117068" checksum="1E17B5D115EB93F1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N641</accession>
    <name>E8N641_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18790"/>
    <dbReference type="EnsemblBacteria" id="BAJ63905">
        <property type="protein sequence ID" value="BAJ63905"/>
        <property type="gene ID" value="ANT_18790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18790"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_0_0"/>
    <dbReference type="OMA" id="QITAYRA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="2">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="399" mass="44889" checksum="08C769A43168D5F3" modified="2011-04-05" version="1">MSQAHKSLSIIFIAVSIVLSACSGIENSGKPTPTPVPQVSNYERSIFTVERGPIVEERKLIGEIVPSKQEELFFRASGYVSRVAFKQGDLVKQGDILAELQVDDLVNQLQQARIDLEVAQANYEREKAQFAFDLEKARVEVFTLQKQVELAQMAVEQSYGLEKQRAQANLEITQQNLKLAEMRLQILEEQSTTYAEQVVKRSQLAVERLEKLLSERQIVSPFDGIVLRSIIRPGQSVDAFFTSFIVGDPKDLVVRVQYDKDLASRMNENTEVLLFLNETDSQGYPVEFLPNFLPISTKVEGASASRFTGDFMYFKVSKEIPQDQIRVGRSVTLKIVLGRKDNALLLPPAAIREYKGLKFVIVQEGDKRRRVEVSQIGLRSLDRVEVIADLEPGDQVVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N685</accession>
    <name>E8N685_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_19230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560324.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19230"/>
    <dbReference type="EnsemblBacteria" id="BAJ63949">
        <property type="protein sequence ID" value="BAJ63949"/>
        <property type="gene ID" value="ANT_19230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19230"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_5_1_0"/>
    <dbReference type="OMA" id="IEPRWIP"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="27"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="198" mass="22432" checksum="7DC9AB3E9F5E9660" modified="2011-04-05" version="1">MDSFRTELLPEEQPAEPKKNPVLNFLWEIVQTVVMAMILYFLVDMMIGRVQVENISMEPTLQPGERLIVNKLAYRLGSIKRGDVIVFHYPRNPNSDYIKRVIGLPGETVRIADGTVYINNEPLQEDYIAAPATYFGEWTVPEGQVFVLGDNRNQSFDSHSWGFVPKEMIVGKAILIYWPPSAIRVLNQTPLVNAAGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A3</accession>
    <name>E8N6A3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme exporter protein CcmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccmA</name>
        <name evidence="6" type="ordered locus">ANT_19410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560340.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63967">
        <property type="protein sequence ID" value="BAJ63967"/>
        <property type="gene ID" value="ANT_19410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19410"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="LIHEPKM"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005895">
        <property type="entry name" value="ABC_transptr_haem_export_CcmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01189">
        <property type="entry name" value="ccmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="27092" checksum="08ED54E984EC1B15" modified="2011-04-05" version="1">MENRALIEVQGLVKRFGPKVVLRGLNFSVLPGEFVALLGPNGAGKTTFLRILASLSSPSMGVVRVAGYLLPREAAAVRRRLGVVSHLPLLYGDLTAEENLRFFGKMYGVNPLEERIREVLRQVGLEKRAKDLVRTFSRGMQQRLAIGRAILHDPDVLLLDEPHTGLDQDACEMLDAILREESSRGRTIVMTSHDLARVEDLSSRFDVLSRGIICASALKQDIPQDGLLAFYRHALGNGQVQRGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6E4</accession>
    <name>E8N6E4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19820"/>
    <dbReference type="EnsemblBacteria" id="BAJ64008">
        <property type="protein sequence ID" value="BAJ64008"/>
        <property type="gene ID" value="ANT_19820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19820"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051627_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="141"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="447" mass="51239" checksum="A256A60D8D1E5C80" modified="2011-04-05" version="1">MSICLTAFYHNGSEIPKEKSGTICCMSKKKTLLTGFAIFTGLIILAVIVWNIPGIQERYGWRLDFARAYVRGVINPVKPLPTPRVVYAASFPTGTPQSTPVLTQEVDVLTPTSSSSPAPTPTITPTPTPLPPQVLLPEPEYVKQDINNCGPATLAMALKFYGWKGAQEDIAKEVKPMRDDRNVNVEELAQYVLHNVGWLRLQYRVGGNIDRLRQFIAAGIPVMIEETFMMEESYWPNDDRWAGHYLLLTGYDDEQKIFIAQDSFVSPNLRVGYSDLDKNWQSFNRVYIVLYYPEQEDTVKAILGEDWDLDKNRMNALKQAQHETQQEPSNAFAWFNLGTNLVYFDRYHEAAQAYDQARKIGLPQRMLRYQFGPFMAYFHDFRIDELMALTEYALKITPNSEEAMLWRGWGLYRLGKREEAYKMFLKALGEHPGYADAQYAIQYVTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6F0</accession>
    <name>E8N6F0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">queA</name>
        <name evidence="6" type="ordered locus">ANT_19880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560385.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19880"/>
    <dbReference type="EnsemblBacteria" id="BAJ64014">
        <property type="protein sequence ID" value="BAJ64014"/>
        <property type="gene ID" value="ANT_19880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19880"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_0_0"/>
    <dbReference type="OMA" id="YSYGDGM"/>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="339" mass="38592" checksum="CAC752FBA2F14ED3" modified="2011-04-05" version="1">MKTSDFDYFLPPECIAQHPVEPRHNSRLMVLNRANDSIQHTIFWNITEYLHPGDILVVNQTRVIPARIYAHKETGGKLEILLLRRVDDHTWEALIGGKRPRKGKSFMINEHLHGTIIEELEESRRLVRFNQPVEPYLERIGQMPLPPYIHEPLRDPERYQTIFARQPGSAAAPTAGLHFTSELIERIAQMGIQFAEVTLHVGLDTFMPVHEENPLEHKIHTEWCELTEETAQKINAAKKEGGRIIAVGTTSVRTLETAAQYAREGEWVGAVSGATSLYILPGYTFRAVDAMITNFHLPRSTLIMLVSAFAGRERILNAYKVAIEQGYRFYSFGDAMLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM6</accession>
    <name>E8MXM6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560477.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20810"/>
    <dbReference type="EnsemblBacteria" id="BAJ64107">
        <property type="protein sequence ID" value="BAJ64107"/>
        <property type="gene ID" value="ANT_20810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20810"/>
    <dbReference type="eggNOG" id="COG4818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2165701_0_0_0"/>
    <dbReference type="OrthoDB" id="1877777at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="110" mass="12573" checksum="4B0F7E4FB9AB0759" modified="2011-04-05" version="1">MSEQFEPVMDVTSDDKLWTLLAYIFTPIIPIVILLLEDKKNRPFIKRHNMQALILGIVEWVVNVLLSFVVIGCVTSVLTVILNIYLGIKANRGETFDIPVISNFVRQQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ3</accession>
    <name>E8MXQ3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_21080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560504.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21080"/>
    <dbReference type="EnsemblBacteria" id="BAJ64134">
        <property type="protein sequence ID" value="BAJ64134"/>
        <property type="gene ID" value="ANT_21080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21080"/>
    <dbReference type="eggNOG" id="COG0555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_1_0"/>
    <dbReference type="OMA" id="MYSFIET"/>
    <dbReference type="OrthoDB" id="1915735at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="70"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="30721" checksum="A4B75663CBE0FB1C" modified="2011-04-05" version="1">MSSLPATKAITVPEAERTSTIWSRWYQQLWKLLALPLLLFFVLPIGTIFVRLSPEDVWKVLQAPQALQALSLSLITATVTTAITSIAGTPLAYLIYRRRSPFTRFIETLIELPSVLPPSVAGVALLLTFGRNGWLGQSLSVMGIQIPFTPLAVVLAQLFIASPLYVKSAALGFASIDCEVRKAAALDGANRWQILRYIVIPLSWQAIVSGLILTWARAIGEFGATILFAGNLPGRTQTMPIAIYIGFETSLELALTLSAILVLISFGILILLKTFLHASNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR9</accession>
    <name>E8MXR9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560520.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64150">
        <property type="protein sequence ID" value="BAJ64150"/>
        <property type="gene ID" value="ANT_21240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21240"/>
    <dbReference type="HOGENOM" id="CLU_2406925_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="92" mass="10426" checksum="0EBF7960DA8F2295" modified="2011-04-05" version="1">MNTNDLILWMPTERPAFIITDWDGNVLEVGGTLSADEVICDLCNALITIRPVPVVWENYAVCLECLDRVMPQWRHVVGEAVVEGWHEQMASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV7</accession>
    <name>E8MXV7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560558.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64188">
        <property type="protein sequence ID" value="BAJ64188"/>
        <property type="gene ID" value="ANT_21620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21620"/>
    <dbReference type="eggNOG" id="COG4113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_1_3_0"/>
    <dbReference type="OrthoDB" id="1878484at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="142" mass="16159" checksum="12443D926329F36D" modified="2011-04-05" version="1">MEAVVIDANIAVGLLVERPWSALAEQKMLEWGSRNIQICVPALWTSEVMSALRKAIYLHQMEQDDALKLVSAMEAWNVQVHLPDTALNRSSLIWAERLGQMVAYDSQYLALAEYLKADFYTVDKKLFNRCQEIGVPFVELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY33</accession>
    <name>E8MY33_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_22380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560632.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22380"/>
    <dbReference type="EnsemblBacteria" id="BAJ64264">
        <property type="protein sequence ID" value="BAJ64264"/>
        <property type="gene ID" value="ANT_22380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22380"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068418_0_0_0"/>
    <dbReference type="OMA" id="GYMRRET"/>
    <dbReference type="OrthoDB" id="834480at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868">
        <property type="entry name" value="PTHR35868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="344" mass="39432" checksum="59CE47EE428F25E6" modified="2011-04-05" version="1">MQVELTQPGVLLNPDGNLAQVGWSRQPLLDCNLEQARFYALKPLQRFRLKRWDYYAVFTPRRFFSATIADLGYAGNLFVYTLDFETGELHEEGIVVPLARGVSLPRNSTEGVSAFADDRLQMTFEVLPNERRVKVNWGAFHEGRGIHADIRLQCLPEYESMNIVIPIGRRRFYFNRKINCLPAEGILRYGGVSETLDPHICLGSLDWGCGVWEYRSYWNWASASGFLPDGRTVGLNLGCGFGDLSRADENALILQNRIHKLEGVRFEYTSGDYMKPWRFRDAQGRLDLVFTPFKERVARTNLGIIFSEVHQMFGRYQGKAVTDDGEEVLIHDLIGFAEEHHARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY68</accession>
    <name>E8MY68_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64299">
        <property type="protein sequence ID" value="BAJ64299"/>
        <property type="gene ID" value="ANT_22730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22730"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_0_2_0"/>
    <dbReference type="OMA" id="IMVRAFR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="156"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="300" mass="33649" checksum="3EE7C732E4ADC98D" modified="2011-04-05" version="1">MRNLSLRNPHPALRFALLLFGVMCGSTAVILIKASNEHPFLVASYRLLLASVILFPFFLRDLKEEPFYGWRQVSWTLLPALALAIHFMSWVVGARMTPVANASLIANLTPVAMPFFVWLFFRERVNRIEVLGTLLTLLGLILLTGFTFRVNPAHFKGNLICFGSMLAFAMYLALGRRNGGRIRLWLYMVPLYFFAGLISLITATFWINPIKPYTLSNILYILALAAIPTVGGHTILNYSLKFFRGQVVSVTNLSQPIFATFLGYLVFKEKPAALFYLAAGIMMAGILMVLHGSRLHQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY85</accession>
    <name>E8MY85_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_22900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560683.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64316">
        <property type="protein sequence ID" value="BAJ64316"/>
        <property type="gene ID" value="ANT_22900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22900"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036138_4_2_0"/>
    <dbReference type="OMA" id="WIMPIMI"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="276" mass="31370" checksum="B0BBE68FA175A91C" modified="2011-04-05" version="1">MWDLLIIQPFTNVLLLIYSYLGQNFGIAIILFTLLIRLITHPLMVSQIKGSQKMMELQNHPRYKELQEKYKNDRQKLQEEQAKLIQELKINPFASCLPLLIQFPIIIGLYQSLYKAMPNTPHDLLNLTRILYSFVDINAILPINNQFLWMDLSQPERLYLPFLPFGIPVLAIVVALTTYIQGRLITPPPSNPNDQTAMMSGMMNLYMPFLMGYMGLTLASGLSLYFIVSNVIGILQYALLGKVNWRNILPARKISGETPVSPAKSVASSRKGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA1</accession>
    <name>E8MYA1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_00120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558444.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62046">
        <property type="protein sequence ID" value="BAJ62046"/>
        <property type="gene ID" value="ANT_00120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00120"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091276_0_0_0"/>
    <dbReference type="OMA" id="FISNARM"/>
    <dbReference type="OrthoDB" id="1028001at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="275" mass="30448" checksum="18266128BBDD69B8" modified="2011-04-05" version="1">MNLQRLWTLARKDWADAFKNTSVVVPMIVLPFFFVVLFPVLFIVIPAFSPQIGQSLASDPDIQPLLNNLPPFLQPYTQGLDVQRTVIVLMLGLMLSPMFLILPLMTSTVIAADSFAGERERKTIEALLYTPASDRELFFGKVLAALIPAVGLTWGSFLVYTLVVNLASYWTMGWVWFPLPTWYPLIFWISPALSLLGVAFTVWISARNPTFMGAYQMSGVLVVLVLPLLFGQIAGVVYLTVEVGLLAGAVIWAVALGLTRFVAHGFNRQRLLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB2</accession>
    <name>E8MYB2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558455.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62057">
        <property type="protein sequence ID" value="BAJ62057"/>
        <property type="gene ID" value="ANT_00230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00230"/>
    <dbReference type="eggNOG" id="COG1106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046693_2_0_0"/>
    <dbReference type="OMA" id="FRRDEIW"/>
    <dbReference type="OrthoDB" id="318943at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="50"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="443" mass="50974" checksum="FCD55F3C99F1E900" modified="2011-04-05" version="1">MLIEFSVANFRSFYQTVTLSLLATPLKEKESRLNTDNLFEVNRLKLLRSAAIYGANASGKSNLVRAIGFMRRFVLDSATEFQSGEKIPVERFRLNREARQKPAVFQIIFALNNKRYRYGFEVDEERVHSEWLYQTVQRESLLFIREGNDYEVSTPFRREAPAKLREMTRSNALFLSVMAQFNSPLAVSLLEWFRKRLQVVSGLKDEFYAPYTMKQLQEHEPFRQFAREMIRLADTGITALSVKSESLDSTKIPAELRKFLQEIAEKTGKPAEEISLRSVETTHPVYAGENFVGNETFDIDDESDGTQKFLYLLGPLFDVLKEGKVLVIDELDARLHPMLSREIVRLFNSPETNPQNAQLIFATHDVGLLGECLLRRDQVWFTQKDRFGASELYSLAEMKERIDASYLKNYLSGRYGGIPLLGGLRPYVEDILKHGTNTEAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB8</accession>
    <name>E8MYB8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558461.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00290"/>
    <dbReference type="EnsemblBacteria" id="BAJ62063">
        <property type="protein sequence ID" value="BAJ62063"/>
        <property type="gene ID" value="ANT_00290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00290"/>
    <dbReference type="HOGENOM" id="CLU_1375733_0_0_0"/>
    <dbReference type="OrthoDB" id="2196555at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="198" mass="20794" checksum="76D56D4F98621BC6" modified="2011-04-05" version="1">MILEWLFRGLEIAALAAAVYLLVGQEWRHGLVALAVVYAVTAVYILSVWSPGLAAVKLVTGWMAVAVLGAAQPAEGWRESPPPGWVGTAFHLVAAALVALLVYSVAPLMARYFPVSAPVMHGGLILAGMGLLHLGMSTRPFREVVALLTTLAGFDLLYTGVEQSILVAGVQSLITLGLALVGSYVITAPSMRTGEGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI1</accession>
    <name>E8MYI1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558524.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00920"/>
    <dbReference type="EnsemblBacteria" id="BAJ62126">
        <property type="protein sequence ID" value="BAJ62126"/>
        <property type="gene ID" value="ANT_00920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00920"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043530_0_0_0"/>
    <dbReference type="OMA" id="SRCMQEI"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="269"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="352"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="477" mass="55381" checksum="979F171ABE879EF2" modified="2011-04-05" version="1">MSEEERHFEMLFEYAPIALMEQDFSAIRQRFEALRAEGVNDLEAFLQNHPEEIDRCMGFIRVVRVNQHTLKMYGVPDRETFLSNLPHFFRDDMRRHFREELLALWQGALTWSGEGINYTLQGNPFDVLLSWRILPGAEETWQEVLVSLEDITARRNAERALEASANRLRGLFENSPISLWEEDYSQIKAIFNDLRSQGVEDLRDYLVEHPEVVTACMQKIRVLEVNRKTLELFGASSVDDLRAHVDRIFRDEMREHFARELVHLWEGELSYEAEGINYTLQGEPLYVHLHLSVYPGSEETFERVLVALEDVTSRHKAEEYLRYLGTHDVMTGLYNRAHFQDEMKRLNEHRSVPVTLLMADLDRLKLVNDTLGHDEGDKLIRCAAEVLKAAFGANDLVARIGGDEFAVLMMNAGEQDGREAIARLETLIRLNNRFYGEPRLSLSMGFSVSQPGENLELAMRRADTEMYRNKREHHHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ6</accession>
    <name>E8MYJ6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Big_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560699.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23060"/>
    <dbReference type="EnsemblBacteria" id="BAJ64332">
        <property type="protein sequence ID" value="BAJ64332"/>
        <property type="gene ID" value="ANT_23060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23060"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606423_0_0_0"/>
    <dbReference type="OMA" id="SASAEIW"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_5" evidence="1">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="451" mass="49874" checksum="A20A3776CF20D2C7" modified="2011-04-05" version="1">MTLTRFDRLVWSILAVLLLALVGITLALPRLGLPAPQPLWGEQGVGARGPVGLQFPRSVDPESAIQAVTIIPPVEGEVKWEGERLLFYPRVPFRQDETYTLSLREGVKARDGRTLKRAFAWTFTVRSPLLAYLFPSASAEIWIQNPGTAEKRAITQTGGRVFDYAVAPDGETLVYSAYNDQQGMDLWQVRRDGSENRKILDCGADWCLNPAFHPQGTWLAYSRRLAPIQQGAQPGVPRVWLLDLTSNTTQPISPDPNVSGSEPLWAPVGRRLLMWDGLSGGLRGVDLEAQQSIVIPSDMGMSATWTPNGKAILFTRMVLGETVAYAEVYRYDWDTQTIERVLGSSEMPRDYSVPVFSPDGQWMAVGLREIQEGPARQLWLFRPDGSEGTLVAGDPLINFSSFHWHPQGNAIALQQITLGSSSARPQVAILDLSTHTVSLLADDATFPQWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYT1</accession>
    <name>E8MYT1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560783.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64417">
        <property type="protein sequence ID" value="BAJ64417"/>
        <property type="gene ID" value="ANT_23910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23910"/>
    <dbReference type="HOGENOM" id="CLU_2630399_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="77" mass="9072" checksum="168A24A1A53C4F9C" modified="2011-04-05" version="1">MPRNRDWQERGVRIGGRVLSEKEAQELVCEIRKRIRDPKVRKEVEEFLAGRQVEISPEALETLRLILVSIAMMRPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYT3</accession>
    <name>E8MYT3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64419">
        <property type="protein sequence ID" value="BAJ64419"/>
        <property type="gene ID" value="ANT_23930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23930"/>
    <dbReference type="HOGENOM" id="CLU_3284016_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="40" mass="5016" checksum="D108F70F1DEA7D03" modified="2011-04-05" version="1">METILAVFLIGGMVGWWIWMLIYLKRDYPIEERLQRYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYV2</accession>
    <name>E8MYV2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24120"/>
    <dbReference type="EnsemblBacteria" id="BAJ64438">
        <property type="protein sequence ID" value="BAJ64438"/>
        <property type="gene ID" value="ANT_24120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24120"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631126_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="163"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="433" mass="45629" checksum="0591855EC27A6B28" modified="2011-04-05" version="1">MWNHPGMNLQQAADAVTVLLAGSIPRLQAWYTALAADARFRVAMQASDPQDLKSKLVTSPDVLVLDAGIYPGPQPLLEDLTRYHGAAYVLLPMEASREAMDSVAQIPCVKGVYKGEMNLVGMAGEMYAAAQAQRQARMSAGMEALWNRPQSGMGAGGAPLGLRVVAVWNQAGGVGKTTIATNLAYEAARRGLPTLLVGMGAPDDLPLILGLKPEPNLNHWRANPTAEGLKLALQKVDTLDVLAGFPDVLSEARAITTPLDAPESIPKLVLTAAYMGYAVIVLDAPPTALASAALAAANTLVLVARPSLEGVMRTVEAYRTVVERLAGEHHIPAAGVYVALNRTGARMGADEWHKAASALLGRPFPPVVAQIPDEPKVGEAQDGRKLPLNVSDGFARGVKPLADALFSPQGAQAPQNGSNGKKSFEIFGVRVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ02</accession>
    <name>E8MZ02_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_01110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558543.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62145">
        <property type="protein sequence ID" value="BAJ62145"/>
        <property type="gene ID" value="ANT_01110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01110"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_6_3_0"/>
    <dbReference type="OMA" id="RIEAQWQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228491" evidence="2">
        <location>
            <begin position="26"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="3">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="243"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="388" mass="42788" checksum="631F372804A3473E" modified="2011-04-05" version="1">MTWKKSILSAVIVLWLAGCSALPWAQSAPQATPVPTVSENGGVLAEAKLVPNDSASLFFLSGGTLAEVLVSEGEQVQAGQVLARLSESAQAQATLAQAKAELLAAQQALDTLNKKAALTAEQARVAMLEAEREAVQAWQAFDRLDTRATRDRIDDLRERAADLQQELQDREETLGRYSNLAADNPTRKRAEDDVEQARLRYNDASRELNQLTNEVELARARWDLANQRLEDARRTYEARQELKPDPDELALAQARVEAAQAAVAAAKEALSRLELRAPFDGTVVEVRYSPGESVAPAQTVLVLADLSEWYAETVDLSEKDVVKIKAGQAVEIIPDALPEVTLKGEVERIALFPLERGGDVVYRVRVRLLESDERLRWGMTVDVRFPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ32</accession>
    <name>E8MZ32_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558573.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62175">
        <property type="protein sequence ID" value="BAJ62175"/>
        <property type="gene ID" value="ANT_01410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01410"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="GRYPHMF"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="36890" checksum="5051A291591F4871" modified="2011-04-05" version="1">MSNSSMNSKDLIIVKNLKKYFPVRAGVFQRVVAHVKAVDDVSFTIKEGECLGLVGESGCGKTTVGRTMLRLTEPTAGSVFYEGTDIFKLKGRDLKAMRRNIQIIFQDPYASLDPRMPIGESVMEGLKIHNIGNPKERFDIAIDTLRKVGLEDYHARRYPHEFSGGQRQRIGIARALALRPKFIVCDEPVSALDVSIQSQVLNILKDLQQEFGLTYLFIAHNLSVVEHISQRVAVMYLGKMVELADRDELFRNPLHPYTQALMSAIPIPDPNIKRERIILKGDVPSPLNPPAGCRFNPRCPVAMEHCKVEEPPFKEVSPSHWVACWRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ63</accession>
    <name>E8MZ63_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01720"/>
    <dbReference type="EnsemblBacteria" id="BAJ62206">
        <property type="protein sequence ID" value="BAJ62206"/>
        <property type="gene ID" value="ANT_01720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01720"/>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="128" mass="14405" checksum="D1FF47DA7BD300F0" modified="2011-04-05" version="1">MQSLERLKRLGVHLCIDDFGTGYSTLWALKQMPMDTLKIDRGFVQGLPHDQDNAAIVQAMIVAAHTLDMEVIAEGVERGEEYRFLVEHGCDRAQGFLFAHPQSAEHTAKVLKLGRLVRFPLGEFARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ80</accession>
    <name>E8MZ80_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ordered locus">ANT_01890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01890"/>
    <dbReference type="EnsemblBacteria" id="BAJ62223">
        <property type="protein sequence ID" value="BAJ62223"/>
        <property type="gene ID" value="ANT_01890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01890"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_1_0"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="441" mass="46320" checksum="D7DFC3BF8D316649" modified="2011-04-05" version="1">MNLIVSPGAPLRGEVRIPGDKSISHRAALFAALAEGESLIENFLDSGVTRAMLNALTALGVTWRLEDECLEVRSPGWRRWKIPAEPLFCGNSATTLRLLAGALAAAGIPAVLDGTPGLRRRPMERIVDPLRAMGVPITAAEGGGAPLTLQARPAESPLRGMSHTLAVASAQVKTCLLLAGLAADAPVEVVEPTLSRDHTERMLKGMGVALEDARLPGGAAWVRLHPPQQPLPPLRGSIPGDFSAAAFLLAAASIVPGSDVLIRGVGLNPTRTGLLETLREMGARIEITHRREVFGEPVGDVRVQASALRAGRVQGERVVAMIDEFPAFAAAALHAEGISTVRDAQELRYKESDRIAALVQEVRRLGGIAEEHPDGFDLSGGAALGGTVHPHGDHRLAMALAVAGLAGVKSVIIEQAEIMAESFPDFVATLQALGAQVKVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ95</accession>
    <name>E8MZ95_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_02040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558636.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02040"/>
    <dbReference type="EnsemblBacteria" id="BAJ62238">
        <property type="protein sequence ID" value="BAJ62238"/>
        <property type="gene ID" value="ANT_02040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02040"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_0"/>
    <dbReference type="OMA" id="NWNKQLT"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07124">
        <property type="entry name" value="ALDH_PutA-P5CDH-RocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005932">
        <property type="entry name" value="RocA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="53"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="528" mass="57980" checksum="A65CBE13C29E48C8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF7</accession>
    <name>E8MZF7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative molybdopterin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_24790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560860.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64505">
        <property type="protein sequence ID" value="BAJ64505"/>
        <property type="gene ID" value="ANT_24790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24790"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_0"/>
    <dbReference type="OMA" id="SRDMHWL"/>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Molybdop_Fe4S4"/>
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        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="708" mass="76945" checksum="EEFA2E0A85ED1A80" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH6</accession>
    <name>E8MZH6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">pheT</name>
        <name evidence="19" type="ordered locus">ANT_24980</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560879.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24980"/>
    <dbReference type="EnsemblBacteria" id="BAJ64524">
        <property type="protein sequence ID" value="BAJ64524"/>
        <property type="gene ID" value="ANT_24980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24980"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_0"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="56"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="438"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="749"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAJ64524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="843" mass="93250" checksum="DFE0E35063E9C78D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH7</accession>
    <name>E8MZH7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24990"/>
    <dbReference type="EnsemblBacteria" id="BAJ64525">
        <property type="protein sequence ID" value="BAJ64525"/>
        <property type="gene ID" value="ANT_24990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24990"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088936_0_0_0"/>
    <dbReference type="OMA" id="PIWKECY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="88"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="32210" checksum="025E425D91F3C790" modified="2011-04-05" version="1">MPLPSASASSAGWSRNWAPGFGVKLNDQDLLAYNRWAWNRQVEQGNRWTIPVSHEQVEAARRGEWEIYLTPTIPVPRGWFPPPGAEILCLASGGGQQGPLLAAAGYQVTVFDLSDAQLARDREVAEREGLHIRLVQGDMRDLSAFADESFDCIVHPVSNCFCPEVRPVWREAYRVLRRGGSLLAGFNNPAIYLFDASILWEQRRLEVRWKLPYDDLHGLTEAQKQECREKGIPLEFSHTYNDQIGGQLEAGFVLTGFYEDRNPPGEEVLSEYLPFYFATRAAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK8</accession>
    <name>E8MZK8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560911.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64556">
        <property type="protein sequence ID" value="BAJ64556"/>
        <property type="gene ID" value="ANT_25300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25300"/>
    <dbReference type="eggNOG" id="COG2888">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118189_0_0_0"/>
    <dbReference type="OrthoDB" id="1472466at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="267" mass="29271" checksum="E528E6DDDB12C3E5" modified="2011-04-05" version="1">MDSPLPSTTLTCTQCGGELHPDEGQVFLTCPYCSATVYVDKSRVVFHWYVAPTLDESQARAALYRWMSGNETVKDLDQKSQVVDVQFQYFPLWYLRVKQNGGEIIRLQPAAATAQTEVAHLQIPAGDLRRYESSLDARAVQPTVPLDAALEWTAQSQEKLEVLESALVHVPLYVFRYVFRGKPFTAIVDGSSARVLANLYPAKDELPYRTVGAVAAGVYLCLALIPVIMGLVSGGENATAGFFICTGLGVVIAPLLLMWALWVAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR0</accession>
    <name>E8MZR0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560963.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25820"/>
    <dbReference type="EnsemblBacteria" id="BAJ64608">
        <property type="protein sequence ID" value="BAJ64608"/>
        <property type="gene ID" value="ANT_25820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25820"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072769_1_0_0"/>
    <dbReference type="OMA" id="RITQGIW"/>
    <dbReference type="OrthoDB" id="1639693at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="334" mass="37897" checksum="B943761819A5902A" modified="2011-04-05" version="1">MVRETISAESVAQAILRRINSGLYAPGDRLPPVRKLAQEIGSNRNTVNKAYQMLLDMGVIELSASGWHGYLVKRVEGGEGKTKSELLNYFYSQFVELVWQGMAAGLSSEELMEIQRKAVGEVYAQSMVEMVFYECNDYDTTEMGKRLNEVLNLPVEYKNISHFYKNPTAVLKSKDLIITTYHHLAELTTAIRQQGFPASKIVGIDTRLTADSLLKIARLPKERIAVICTNQNTAHTIKHTLYGYRPEWQIEAMAAENPDAVRRLVEWCDHLIVTHTSADQIQEWTGRMPDVVVNFQIDEQSIAFLNQRIHQIRMQKLQGDSHAEGIEGKNLDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT1</accession>
    <name>E8MZT1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26030"/>
    <dbReference type="EnsemblBacteria" id="BAJ64629">
        <property type="protein sequence ID" value="BAJ64629"/>
        <property type="gene ID" value="ANT_26030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26030"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302802_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="211" mass="23985" checksum="2614868F3CF262C9" modified="2011-04-05" version="1">MTKNENGFLIHHYKAVGFMSHVAVTLEYDQKTFDLALPLHVPVYRLVEWILSYLNLSTTSGYRYTLAIKSANGIYRISPNTSLGERGVCHGMFLVLIKDDLQLQTESFLQTEGGKKIPIKSRKTILGRNDPNNGIYVDIDISSLAEKPSIISREHAKIEQDENNFYLVDLKSKNGTKLNGQWLTPQQKYLLNDGDVIEFGKSAIKLKFFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW9</accession>
    <name>E8MZW9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methylmalonyl-CoA epimerase</fullName>
            <ecNumber evidence="4">5.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_02700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558701.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02700"/>
    <dbReference type="EnsemblBacteria" id="BAJ62304">
        <property type="protein sequence ID" value="BAJ62304"/>
        <property type="gene ID" value="ANT_02700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02700"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_0"/>
    <dbReference type="OMA" id="IHHICYE"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="14667" checksum="0200F30FF5864B22" modified="2011-04-05" version="1">MSEIKKINHVAIVVGDIDQALTFWRDALGLELHHVEDVPSQKAVVAFMPVGDSEVELVKPTTDDSGVAKFLAERGGGMHHLCFEVDDLEAKLADLKAKGVRLINETPIELPGRKMAFIHPKSTGGVLVELYQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY0</accession>
    <name>E8MZY0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558712.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02810"/>
    <dbReference type="EnsemblBacteria" id="BAJ62315">
        <property type="protein sequence ID" value="BAJ62315"/>
        <property type="gene ID" value="ANT_02810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02810"/>
    <dbReference type="eggNOG" id="ENOG5033KCV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2079843_0_0_0"/>
    <dbReference type="OMA" id="ANDVRIQ"/>
    <dbReference type="OrthoDB" id="2179472at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225353" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="12096" checksum="489D8A504D4B68BF" modified="2011-04-05" version="1">MTKKMRVAYAVVFALILAALTFAYAAANTVPVTYAGDGSSITSGYTVSNVHYVLDTTNPANISQVTFSLDAPANDVRIQLVNGGAWFSCSTAGTSVTCNVSGVTVLAANTLRVVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N008</accession>
    <name>E8N008_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_03090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62343">
        <property type="protein sequence ID" value="BAJ62343"/>
        <property type="gene ID" value="ANT_03090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03090"/>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_0_2_0"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="335" mass="37455" checksum="FD34C94D409527F5" modified="2011-04-05" version="1">MSVNVGMWMKALQVIPRITREEWEKLDVISRWLISTRAAVLIMTFTSATIGGLLAARDGKFNLVLWLLVALGLVLAHALNNLLNDLTDYERGIDENNYFRAQYGPHPLQQGLMTRKQLLTYAAVTGALALAAGLYLVFLRGWLALVLLALGAFFVFFYTYPLKYIGLGEAAVLLVWGPLMIGGSYFVITGEWSWMAVLAGLPYALGPTTVIYGKHIDKLDADRQKGVRTLPVIIGEKAARASVRVMIVLMYALVAVLVLVGYFTPAMLIVFFALRYLPETWKMLGSPRPSEPPAERKDIWPLWFVAANFYHNRVYGMLFLLGLIADAILRNILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N020</accession>
    <name>E8N020_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62355">
        <property type="protein sequence ID" value="BAJ62355"/>
        <property type="gene ID" value="ANT_03210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03210"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198111_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="54" mass="6056" checksum="6A510C31D3F59A22" modified="2011-04-05" version="1">MGLQPLDALHLALAETGKADYFCTCDDRLLRKSKQIELQVKGVSPVELIQEIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J4</accession>
    <name>E8N0J4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_27170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561095.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27170"/>
    <dbReference type="EnsemblBacteria" id="BAJ64743">
        <property type="protein sequence ID" value="BAJ64743"/>
        <property type="gene ID" value="ANT_27170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27170"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_0_0"/>
    <dbReference type="OMA" id="QARYSIV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="77"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="525" mass="60226" checksum="891C16E3239FFFAE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0K2</accession>
    <name>E8N0K2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_27250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561103.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27250"/>
    <dbReference type="EnsemblBacteria" id="BAJ64751">
        <property type="protein sequence ID" value="BAJ64751"/>
        <property type="gene ID" value="ANT_27250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27250"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_0"/>
    <dbReference type="OMA" id="CECLNLP"/>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="315"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="439" mass="48407" checksum="CCB047B1FBECF998" modified="2011-04-05" version="1">MSKICVIGTGYVGLVTGACFADLGNTVTCLDVDETRIERLKQGIMPIYEPGLEQIVLQNVRHGRLHFTTSYPEALKDAEFAFIAVGTPSGVDGEADLQYVRQAAEAIADIVDHPIIVVNKSTVPVGTGDWVAEVINRRRAGKPLEFSVVSNPEFLREGSAINDFMMPDRVVLGSLHRQAAEKVAQLYQSLRCPIMITDLRTAEMIKYASNAFLATRISFINEIANICEELGADVREVARGMGLDKRIGPAFLDAGLGWGGSCFPKDVKALAHMAVLHGTHPQLLQAVMEINRNQRRRVVVKLRKALGTLDQKVIGVLGLSFKPNTDDIREAPALEVIHLLENEGALVKAYDPQAMENARSVLPRVQLVETPYQVAEGADALVLATEWNEFKQLDFEQIYRSMRQPVIMDARNLWNPDQLRAMGFTYFGIGRGNSVPPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L0</accession>
    <name>E8N0L0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_27330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27330"/>
    <dbReference type="REBASE" id="32160">
        <property type="entry name" value="M.AthUNI1ORF27330P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64759">
        <property type="protein sequence ID" value="BAJ64759"/>
        <property type="gene ID" value="ANT_27330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27330"/>
    <dbReference type="eggNOG" id="COG2521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_3_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="167"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="263" mass="30923" checksum="1C220C4E873DE4D5" modified="2011-04-05" version="1">MADYKSIQLTNFEVDKKVLDIVNNCLSQQPDPRPFVEINSIGYVFYFHTLDIKLLQRNIEMLTAHDLFSANNPSSSRKAGELLQKIYEEVSKIGSYGIRSGKRQYVNFDIERKVRNRKAKEQNRSQYYYAQDNNFSKISNQLPPEMTNQIFCGDSLEVLKKIPDNSIDLIFTSPPYNFGLEYERQDDAHKWDLYFEKLFAIFDECIRVLKFGGRIAVNIQPLFSDYIPSHHLISNFFISRRMIWKGEILWEKNNYNLLCCNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N5</accession>
    <name>E8N0N5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558826.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03960"/>
    <dbReference type="EnsemblBacteria" id="BAJ62430">
        <property type="protein sequence ID" value="BAJ62430"/>
        <property type="gene ID" value="ANT_03960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03960"/>
    <dbReference type="HOGENOM" id="CLU_982260_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="283" mass="32330" checksum="079144F0173FA63C" modified="2011-04-05" version="1">MFSPVFMLPRRGFYLILAVILLLLLTGCPPKFPCDEKIKDPEPYQQMVLQHPLIQALSETLTIEEVRIGACFVKGKANAAVMFRTPSDFSSLGMLYRGSFDFIFTKDGTLSIPEDGFWEIRDWEISSWDGKSIDLIVGAIRKKIDELESNPRVHEVLTRTQADPLNAANHLNTGQIFRKNARLTYAFRAHQVREYLLPSDIEWETFPEIHQAHEIIQTRLLTGELSNCTIGTGELHNYTGAQIDELGGWYMTVALQCNEKWKDAFLHLLSDGSFERLSIQTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q7</accession>
    <name>E8N0Q7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_04180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558848.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62452">
        <property type="protein sequence ID" value="BAJ62452"/>
        <property type="gene ID" value="ANT_04180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04180"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="APIWVRR"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="26753" checksum="8B40BCE01EB03A20" modified="2011-04-05" version="1">MEPIIHIENVHKYFGRVHALRGVSLDVQKGEVVVIIGPSGSGKSTLLRCINRLEEFDKGRIVVDGIPLDSAENINAVRTEVGMVFQQFNLFPHLSVLENITLAQKIVRKRSDSEAVKIAMDLLEKVGIPEKAHAYPAQLSGGQQQRVAIARALAMNPKIMLFDEPTSALDPEMIQEVLDVMLQLAREGMTMVVVSHEMGFSRNAADRVIFMDGGVIIEEGPPSVIFSNPTQERTKLFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S3</accession>
    <name>E8N0S3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prok-JAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_04340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558864.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04340"/>
    <dbReference type="EnsemblBacteria" id="BAJ62468">
        <property type="protein sequence ID" value="BAJ62468"/>
        <property type="gene ID" value="ANT_04340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04340"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_1_1_0"/>
    <dbReference type="OMA" id="GAHYVLV"/>
    <dbReference type="OrthoDB" id="1811367at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prok-JAB" evidence="6">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="135" mass="15105" checksum="8C08475D0F00F93F" modified="2011-04-05" version="1">MRFPEDMVEQILNHMQGNLQEERCGLIGGVNGEAHLFLPITNILHSPTRFRMDASEQWQAFQTFEAQGLELMAIVHSHPNGPSVPSPTDLAEFAYPGVLYLIAAPTAEGWQLRGFWLDEGQIREEGLEISRNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S9</accession>
    <name>E8N0S9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558870.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04400"/>
    <dbReference type="EnsemblBacteria" id="BAJ62474">
        <property type="protein sequence ID" value="BAJ62474"/>
        <property type="gene ID" value="ANT_04400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04400"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056890_0_0_0"/>
    <dbReference type="OMA" id="AFAMIWE"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="174"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="347" mass="39618" checksum="E08D545586BA47F6" modified="2011-04-05" version="1">METKIFLPSSFTSRPATLTDAEAVANLLNLCFVEWTGSPETSTQDLHSFWTNPMMNLERDTLLILDTHQQVVAYGEMYDAPPHVRLYLYGRVHPQSRGKGLGTALVQWGLARASLSLEKAPADARVVLHQFLPAQAVEGARLLESLGFRHIRNSYQMRIELSTPPQAASFPAHIQVRTVHLENELEALVRAHRQAFHDHWGYVETPMEEALKDWRHWVETDPRCDPTLWFLAMDGDEIAGYCLCSPGTEEDPQLGWVNLLGVRREWRKQGLGLALLLHGFDALYQRGFHRIGLGVDASSLTGATRLYQRAGMHVHREYHLFEYEVRPGKDYLRQSLEDHEREKDTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W5</accession>
    <name>E8N0W5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04760"/>
    <dbReference type="EnsemblBacteria" id="BAJ62510">
        <property type="protein sequence ID" value="BAJ62510"/>
        <property type="gene ID" value="ANT_04760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04760"/>
    <dbReference type="HOGENOM" id="CLU_1640295_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228540" evidence="1">
        <location>
            <begin position="33"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="161" mass="16800" checksum="0B85D0751D3496D1" modified="2011-04-05" version="1">MKTGGAMHALRLALLGLALLALLVLPPSQSSAQSSSISLQIQNPVCMQSSLDSGTCYIRMRSISAVGSGSSFSRLQVFVNGKLRANTGGFFENSGYVVGNMFGSGFVVSCGGKNASGDPDFGQSYTIQVVASLADSTTTTGSIAVFCPYYEGKSFLPFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N103</accession>
    <name>E8N103_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558944.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05140"/>
    <dbReference type="EnsemblBacteria" id="BAJ62548">
        <property type="protein sequence ID" value="BAJ62548"/>
        <property type="gene ID" value="ANT_05140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05140"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_0_1_0"/>
    <dbReference type="OMA" id="ICQKDAF"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="269" mass="28649" checksum="9B7904809E83C659" modified="2011-04-05" version="1">MSEYTNTAGQRLDLPEPVVSLSGRTMGGADYQIIGTVMQALTLRMKPGMGFYTEVGSLSWMSQGVRMDTNLGKGGLMGALGRMFTGESLFVVNYTAEIDGAMATFSCDFPGKIVPVNLAQGQAMIAQKDTLLVAEQSVSLSIAFQKRLGAGLFGGEGFILQKFEGPGTFFASFDGEIVEYTLQPGQKMLVDTGHLAMFEPTVTYDVQMVKGVKNLLFGGEGLFLVSLTGPGRIWLQTMPMSKLAGAIHKFMPSAEGKSQGPGLNINLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N127</accession>
    <name>E8N127_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_05380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558968.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05380"/>
    <dbReference type="EnsemblBacteria" id="BAJ62572">
        <property type="protein sequence ID" value="BAJ62572"/>
        <property type="gene ID" value="ANT_05380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05380"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_0_2_0"/>
    <dbReference type="OMA" id="VMERRFA"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="365" mass="40276" checksum="319720057CCA262F" modified="2011-04-05" version="1">MPPIYPFTAIVGQERMKRALVLNAVDPRIGGVLIRGERGTAKSTAARALAALLPKVKVVSDCRFGCDPDAPATWCTECRERAERGESLPVSLRQIPFINLPVSATEDRVVGTLDIEAAIQRGERHFEPGVLAAANRGLLYIDEVNLLDDHVVDVLLDAAAMGMNIVEREGISFTHPARFILVGTMNPEEGDLRPQLLDRFALSVEIYGIRDARERVMIMERNLAFEKDPLAFVAHWQPKEQELSQQIEQARKLLDQVTYTSRDLLSIASLTASLQVDGHRPDLVILKTARAHAAFEGRTSITARDIALAAELALPHRLKRTPFQQASATMEELAERIEQLQGGATSGEPREHPGGMEEESGQKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N167</accession>
    <name>E8N167_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561157.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64810">
        <property type="protein sequence ID" value="BAJ64810"/>
        <property type="gene ID" value="ANT_27840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27840"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415424_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="660" mass="70713" checksum="18B7FC746573E180" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N172</accession>
    <name>E8N172_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_27890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561162.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27890"/>
    <dbReference type="EnsemblBacteria" id="BAJ64815">
        <property type="protein sequence ID" value="BAJ64815"/>
        <property type="gene ID" value="ANT_27890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27890"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_0"/>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="258"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="520" mass="57440" checksum="EF3CCD9932802240" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N177</accession>
    <name>E8N177_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_27940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561167.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="anatu-e8n177">
        <property type="family name" value="CarbLipBact_2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64820">
        <property type="protein sequence ID" value="BAJ64820"/>
        <property type="gene ID" value="ANT_27940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27940"/>
    <dbReference type="eggNOG" id="COG1647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076594_0_0_0"/>
    <dbReference type="OMA" id="DWYAEVD"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="29039" checksum="4153C5C9E85F2259" modified="2011-04-05" version="1">MNQPNLHNPHLNGEPFFWQAGPIGILMIHGFTATPVEVRMVAERLHPHGYTVAAPLLPGHGTHPDDLNRVRWQDWVAKAEESYQQLKQTCQKVYLLGESMGALVALYLAAEHREAEGVIASAPAIRLLISPLQKAALPLLSLFKASMPKGGLDASSNWQGYPVNPLKGVQQLFRFQKEVERRLPEIVQPILVLMGRYDTTVHPEAGKFILERVSSPYKSLVWFENSSHVILIDQEVDAAAERIERFIKETSNDGMPALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8N179</accession>
    <name>E8N179_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64822">
        <property type="protein sequence ID" value="BAJ64822"/>
        <property type="gene ID" value="ANT_27960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27960"/>
    <dbReference type="HOGENOM" id="CLU_1552109_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="172" mass="18606" checksum="36BDEFB652153047" modified="2011-04-05" version="1">MSLIKGCDMKHFHRVLWLMLIGLLGMASCAPLSVPEGQPSATVSSLEAKSLPQWQVRLSQSGGFAGVSRRVELDSNGALKVSDENSGVEITTNLPPEALKEIAALVLEAQAGEQKPVPPGSACRDCFNYVLTIERDGERIQVRADDMTLNQVPLEPLISRLLELQKEALSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N180</accession>
    <name>E8N180_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative thermolysin family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_27970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561170.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27970"/>
    <dbReference type="EnsemblBacteria" id="BAJ64823">
        <property type="protein sequence ID" value="BAJ64823"/>
        <property type="gene ID" value="ANT_27970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27970"/>
    <dbReference type="eggNOG" id="COG3227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010362_0_0_0"/>
    <dbReference type="OMA" id="FEDWENG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FTP" evidence="10">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="8">
        <location>
            <begin position="262"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="9">
        <location>
            <begin position="376"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="771" mass="83110" checksum="27661B2D4FE9E9C0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C2</accession>
    <name>E8N1C2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_28390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561210.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28390"/>
    <dbReference type="EnsemblBacteria" id="BAJ64865">
        <property type="protein sequence ID" value="BAJ64865"/>
        <property type="gene ID" value="ANT_28390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28390"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102055_2_0_0"/>
    <dbReference type="OMA" id="CCYRNIC"/>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="15"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="203" mass="23581" checksum="F4A1A42289069A35" modified="2011-04-05" version="1">MLDPTEEIYEYPFRVTDLKQWVYCHRLLYFLVCLPDVRPRTYLMDAGKEAGEGEEGRELRRSLKSYRLVEGRREFNVAVRSSRWGLRGLVDLVVWVDAPPPGEVIPVDFKLSFKSGEHVQMQLMAYGLLLEELSGRPAPRGYLVEIPLRRVVEVPFTPALRRKVEDALQAMKAMLESEQMPEPTSQRMRCLGCEFRRFCNDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E5</accession>
    <name>E8N1E5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561233.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64888">
        <property type="protein sequence ID" value="BAJ64888"/>
        <property type="gene ID" value="ANT_28620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28620"/>
    <dbReference type="eggNOG" id="COG2035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055621_0_0_0"/>
    <dbReference type="OMA" id="LGLFDPM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="298" mass="32652" checksum="C49FA085A2C2554D" modified="2011-04-05" version="1">MPQRTFRDDLGISLRGFLMGAADVVPGVSGGTMAFILGIYDELIASIRAVVPFIRRVLSGQWRLAFEEFPWRFLLALGLGIAVAILSLARLLHWALETHPTLIYALFFGLIVASVFVVRQRVARWTWGRLFIMGVFAAGAYFLVGLRPAQTPDALWFIFLSGMIAICAMILPGISGAFILVLLGKYQTLLGALVQMDWLTIGVFMSGALIGIVSFASFLRWLLDHYHDATVAGLTGFMLGSLRELWPWKQAQYVEDVPVAVHNVLPSSLDGEVGLALGIMLLGAGLVLGMETLAKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K8</accession>
    <name>E8N1K8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase molybdopterin binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559008.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05790"/>
    <dbReference type="EnsemblBacteria" id="BAJ62613">
        <property type="protein sequence ID" value="BAJ62613"/>
        <property type="gene ID" value="ANT_05790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05790"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_1_0"/>
    <dbReference type="OMA" id="TSYIEWT"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
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        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
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    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
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        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
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        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="782" mass="84445" checksum="00157062695AAA1D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N2</accession>
    <name>E8N1N2_ANATU</name>
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        <submittedName>
            <fullName evidence="12">Na(+)/H(+) antiporter subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mrpA</name>
        <name evidence="12" type="ordered locus">ANT_06030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559032.1">
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    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06030"/>
    <dbReference type="EnsemblBacteria" id="BAJ62637">
        <property type="protein sequence ID" value="BAJ62637"/>
        <property type="gene ID" value="ANT_06030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06030"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_2_1_0"/>
    <dbReference type="OMA" id="AFILQYM"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        <location>
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    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="10">
        <location>
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            <end position="110"/>
        </location>
    </feature>
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        <location>
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            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="11">
        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="775" mass="83399" checksum="E981AAF7D0906331" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N6</accession>
    <name>E8N1N6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="10">6.3.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_06070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.4" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559036.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06070"/>
    <dbReference type="EnsemblBacteria" id="BAJ62641">
        <property type="protein sequence ID" value="BAJ62641"/>
        <property type="gene ID" value="ANT_06070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06070"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_2_1_0"/>
    <dbReference type="OMA" id="YSEEQCA"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
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    <keyword evidence="1 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ62641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="400" mass="44278" checksum="FAF8BA7AD59EBA50" modified="2011-04-05" version="1">MDTTIFIQEELDPDPEKPPSSRPRPARPWRVAVIANVKGETALPIQAPPDAGAEFDRKETIEAIQSAIESDGHTTRFLSADHTLLDSLREYQPDICFNIAEGIIGDAREAQVPALLEMLGIPYTASRVLANALGLDKTMTKRIWRNLGIPTASFQEFITGDEPLEADLSFPLFVKPAREGTGMGMDEGSIVYNENQLRRRVKWVIEAYHQPALVETYLPGREFTVGVLGRADARRWSPKPHLYRADGFHRFPILEVDNSNTVTPGVYGYAAKTLHPGEEGVPGFICPAQVEPDLAEKLWTLAIRAHNAIGALDVSRVDVRLDAHGNPRLLEINTLPGLTPGFSDLCVIAQAEGLSYRDLILEILYLGASRWGLLEEAPQAIHVPLQAHHHTFQPAPMIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P1</accession>
    <name>E8N1P1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62646">
        <property type="protein sequence ID" value="BAJ62646"/>
        <property type="gene ID" value="ANT_06120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06120"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_9_2_0"/>
    <dbReference type="OMA" id="MWRTIME"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="103" mass="11515" checksum="29E62F2D861AD64B" modified="2011-04-05" version="1">MDAAVRAWAAQLASAHPEVLKVGYWGSYARGDWGVGSDVDLVLILSRSDLPFDQRGRTLDATSLPVPADLLVYTLEEWLNLPEEGRFKKTLASEIVWVFERNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q6</accession>
    <name>E8N1Q6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_06270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559056.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06270"/>
    <dbReference type="EnsemblBacteria" id="BAJ62661">
        <property type="protein sequence ID" value="BAJ62661"/>
        <property type="gene ID" value="ANT_06270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06270"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_0"/>
    <dbReference type="OMA" id="WLQNRNG"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="183"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="47158" checksum="6EE8C4FC793ED13A" modified="2011-04-05" version="1">MSGMINEFEMAQRQFDHVASLMHLDPQVAEFLRWPMREYHFRIPVRMDDGTIRTFQGFRVQHNDARGPNKGGIRFHPAETIDTVRALAFWMTWKCAVADLPLGGGKGGVVIDPATLSTAEKERLCRGYVDIMWRNLGPRTDVPAPDVGTTPQMMGWMMDEYSKLVGQYTPGVITGKPLGGGGSAGRTEATGYGVIYTVREAMKMLGIDSRGTVAAIQGFGNVAQYAAIGFVEMLGGKVACVSYWDREDRCAYTVSKEGGIDPHFLMSITDQYGTIDKNKAVAAGYKIEDGEAWITKEADVLIPAALSGTINAETVKGVHERVKIVAEGANGPTTPEADELFKARNIFVIPDFLCNAGGVTVSYFESVQNDMNYYWTKEEVLSRLDTKITTAFHGVVEMAQKQGVFMRDAAYMVAIDKVVKAMQLRGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T7</accession>
    <name>E8N1T7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559087.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62692">
        <property type="protein sequence ID" value="BAJ62692"/>
        <property type="gene ID" value="ANT_06580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06580"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_21_0_0"/>
    <dbReference type="OMA" id="PSAYFYH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="257" mass="29719" checksum="AEAC2643025F9ED1" modified="2011-04-05" version="1">MTLVTIVTPSFNQARFLEETMLSVLHQDYPHIEYIVVDGGSTDGSVDVIRRYADRLAWWVSEPDRGQTDAINKGFAHAHGEILAWLNSDDTYQPGAVRAAVEALEKHPEAAMVYGDAHYIDENGRVIGRFPAAQTDYRRLRQGYVHIPQQAAFWRASYWRQVGPLDPTFYFAMDYDLWVRLAALAPLVYIPGQVWANFRLHSDAKTISADDRCWPEMLRVHRRLGGGWFAPIVFKYYLRRLVAPYIRWKRKRLFTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V0</accession>
    <name>E8N1V0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559099.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06710"/>
    <dbReference type="EnsemblBacteria" id="BAJ62705">
        <property type="protein sequence ID" value="BAJ62705"/>
        <property type="gene ID" value="ANT_06710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06710"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_5_2_0"/>
    <dbReference type="OMA" id="PLYLFQL"/>
    <dbReference type="OrthoDB" id="1783638at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="366"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="564" mass="61531" checksum="6E3AE5F1A1C87E1A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H5</accession>
    <name>E8N2H5_ANATU</name>
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        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ62781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559174.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
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        <property type="gene ID" value="ANT_07470"/>
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    <dbReference type="KEGG" id="atm:ANT_07470"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="1832232at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="264" mass="29252" checksum="5C76D7980239BD0D" modified="2011-04-05" version="1">MSEQTMTAFEVATPSTAIQPYLRVEDVHMRYPNDNGGVEALHGVQFDLHPREFVCLLGPSGCGKSTLLRIIAGLLTPTRGEVIFYAPTASRISLVFQDANLMPWRNVRENIALPLILQGVPRSQALQKADAWLDIVGLQGFGEALPRELSGGMAQRVAIARSLIQEPGLLLLDEPFGALDALTREKMASELLRLWQEHRTTVLMVTHSISEAILLSDRVLVLSSRPGRVVLDLAIDLPRPRDEDVRYTPEFGALARELRRAITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2M4</accession>
    <name>E8N2M4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559222.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07960"/>
    <dbReference type="EnsemblBacteria" id="BAJ62830">
        <property type="protein sequence ID" value="BAJ62830"/>
        <property type="gene ID" value="ANT_07960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07960"/>
    <dbReference type="eggNOG" id="ENOG5032UR2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131310_0_0_0"/>
    <dbReference type="OMA" id="FINTMLF"/>
    <dbReference type="OrthoDB" id="1834688at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025517">
        <property type="entry name" value="DUF4405"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14358">
        <property type="entry name" value="DUF4405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4405" evidence="2">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="172" mass="19635" checksum="FBD78C323BED4E91" modified="2011-04-05" version="1">MNKINFLLDAGIFLAFLLALEPELTGLEIHEWLSVALAGTLILHLFLHWDWVVGVLKTFFCKLIHISRLKFVVDALLLVAMIAVMVSGLMISRVVLPVLGLTVPENQDWRMLHTLSADLVLWLTALHFALNWKWVVSMIKRYVVAPIASLQWRTVKPQVQPIPVEIEHNRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P0</accession>
    <name>E8N2P0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NagC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559238.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62846">
        <property type="protein sequence ID" value="BAJ62846"/>
        <property type="gene ID" value="ANT_08120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08120"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_0"/>
    <dbReference type="OMA" id="FFIRHQQ"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="381" mass="41267" checksum="6A53FE41543454D0" modified="2011-04-05" version="1">MEKATHQQTKAHNRNLVLKTIFEHEAISRAEIARKTQLTRATVSELVNELLTEGIVEEVGTGASIGGKSPILLSLVPDSRFLIGVNLGQDNFIASVVNLRGEIKETIESPALRHNPDETLALVIDMLESLLQKQWKPIVGIGIGAPGLIHTRQGMVLRAVNLDWENFPLAHLLEERFHMPVSILNDSQATAIGEFVYGKHVSSGNLIVVNIRHGIGAGILINGRLFQGDGSAAGEIGHVVVNPQGDVCRCGKRGCLETIASAGAVLRRTGVASLSEALERWENGNSGMQAVVAEAGNALGEALAHLVGALNIHHIVLTGEMTRFGEPWLESVRHAMQKAAFHPLVEDTRLEIGMLDYRACILGAAAFMVLEDYDLLFLQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Q1</accession>
    <name>E8N2Q1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="2">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-IPM isomerase</fullName>
            <shortName evidence="2">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">leuD</name>
        <name evidence="4" type="ordered locus">ANT_08230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559249.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62857">
        <property type="protein sequence ID" value="BAJ62857"/>
        <property type="gene ID" value="ANT_08230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08230"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_1_1_0"/>
    <dbReference type="OMA" id="GLPIIEC"/>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="1 2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="3">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="164" mass="17978" checksum="E934FD6A7E19C8E4" modified="2011-04-05" version="1">MGRAWKFGENLNTDEIIPARYNITIDEKELAAKAFCEIRPEFAAQVQPGDVIVAGRNFGCGSSREHAAVAIRGTGVQCVIAPSFARIFFRNAINIGLPILECPQAVEIEDGDQIEVNLSRGEIRNLSQGKVYPANPLPAFVLKIVEAGGLVRFLREHDIEELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Q3</accession>
    <name>E8N2Q3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine biosynthesis protein LysX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysX</name>
        <name evidence="6" type="ordered locus">ANT_08250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62859">
        <property type="protein sequence ID" value="BAJ62859"/>
        <property type="gene ID" value="ANT_08250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08250"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_2_1_0"/>
    <dbReference type="OMA" id="CYMNIAS"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="93"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="31033" checksum="6D66EC7C9784C778" modified="2011-04-05" version="1">MIRVGFLFTRLRVEEKYLLEELTRRPGVDVVQINDGDTFFDIAHPPLGVDVLFERSVSYSRGLYISRIYAAHGVPVVNPPALAERCGDKYVTSQILVQAGIPTPRVLMAFSEEAALAACEEMGYPCVLKPVVGSWGRLLAKVNDRASAEAFIEHKATLGGVNHQIFYIQEYIEKPGRDIRAFVVGEEAIGAIYRNSENWITNTARGGQASNCPVTAELAEICARVAWAMGKGLLAIDLFETPQGLTVNEVNHTMEFRNSIATTGVDIPARMVDYVLSQVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T2</accession>
    <name>E8N2T2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">cysS</name>
        <name evidence="13" type="ordered locus">ANT_30560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561423.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30560"/>
    <dbReference type="EnsemblBacteria" id="BAJ65082">
        <property type="protein sequence ID" value="BAJ65082"/>
        <property type="gene ID" value="ANT_30560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30560"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_0"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="12">
        <location>
            <begin position="352"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ65082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="468" mass="52877" checksum="33C68971D4130A36" modified="2011-04-05" version="1">MALKIYNTLTRKKEPFETLEPGKVRMYVCGPTVYNKAHVGHAMSALVFDIIRRYLEYRGYQVKHAMNYTDVDDKIILRASQLGMDPFALAETYIQEYRKNLEDLNVLPATINPRATQEIDQIIAIIQGLIEKGYAYPAPNGDVYFRVTRDEDYGRLSGRKLDEMQAGARIEVGEQKEHPMDFALWKAAKPGEPAWDSPWGKGRPGWHIECSAMNLHHLGEQIDIHGGGNDLIFPHHENEIAQSESYTGKPFARYWVHNGMLQFGGEKMSKSLGNLVTIEEFLARHDADVLRLMVLNSGYRAPLTFNDDVIEQTERALERLKSALRPALPGAAGISAEAVKALEEQARAARAGFEEAMDDDFNTAGALSHLFELVRAINSARTEGATDEQLRVGQDVLRELAGVLGLRLRMEEEKPQEAAPFIDLLIEVRTELRKQKLWALSDLIRDRLTALGVTLEDTREGTTWRYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V2</accession>
    <name>E8N2V2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561443.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30760"/>
    <dbReference type="EnsemblBacteria" id="BAJ65102">
        <property type="protein sequence ID" value="BAJ65102"/>
        <property type="gene ID" value="ANT_30760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30760"/>
    <dbReference type="eggNOG" id="COG5511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_570856_0_0_0"/>
    <dbReference type="OMA" id="AWGENER"/>
    <dbReference type="OrthoDB" id="816872at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006429">
        <property type="entry name" value="Phage_lambda_portal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05136">
        <property type="entry name" value="Phage_portal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="430" mass="48522" checksum="0F71D68766291192" modified="2011-04-05" version="1">MWKTILHRWIEPEVRRRVQMALAETDNTLLIRAQAWGENERLTPDREQTLEQALHAWRTNPLARRIVELTTEYVIGGGLAVVSPQAEAQTFLQRWWEHPLNRLPMRTVEWCDELSRAGELFLLLSTDAGGMTYVRAIPALQIRAIRTAENDLQQEIACLQVDGAGEERWWQVYNPQSDMPDEQGRFAPAILHYAINRPVGAVRGESDLAPLLRWLNRYAGWLEDRARLNRYRNTFLFTVRSRFASEAERLARQQTLAANPPMPGSILVTDEGEEWSVIQPHLESHEAGEDGLALKKMIAAGAGIPLHFLAEPESATRTTAEAAGGPAYRRLEQRQKFFCWLVEDTARACLRRWAWIHGRSGEYEVQVRGADLSARDNASLAAALAHASGALMRLYERGLIGESELLRLVYRFAGETAPASANPSTEKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W1</accession>
    <name>E8N2W1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NifU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561452.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30850"/>
    <dbReference type="EnsemblBacteria" id="BAJ65111">
        <property type="protein sequence ID" value="BAJ65111"/>
        <property type="gene ID" value="ANT_30850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30850"/>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_4_3_0"/>
    <dbReference type="OrthoDB" id="2010888at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="89" mass="9831" checksum="C9977E9792910C8D" modified="2011-04-05" version="1">MVTTNGKSFEYSTEERLRALIETLDTYIQQYHGGSVEMVGFDGKVLKVRLGGACEGCPLSPTTINGWVAGTVRQFFPEIEKVEAVEEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N383</accession>
    <name>E8N383_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cdd</name>
        <name evidence="13" type="ordered locus">ANT_08630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08630"/>
    <dbReference type="EnsemblBacteria" id="BAJ62897">
        <property type="protein sequence ID" value="BAJ62897"/>
        <property type="gene ID" value="ANT_08630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08630"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_1_2_0"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ62897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="14893" checksum="79C3DDBF374857B2" modified="2011-04-05" version="1">MKLSDEQKQTLIQTALQARRWAYAPYSNYRVGAALLTDSGKIYDGVNVENAAYPVTMCAERTAVFKAVSEGERRFVAIAVATANGGTPCGSCRQVLAEFGLDIQVIVVDEQGTVHLETTVSDLLPGAFTSKQLPPQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A1</accession>
    <name>E8N3A1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alpha-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_08810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559307.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08810"/>
    <dbReference type="EnsemblBacteria" id="BAJ62915">
        <property type="protein sequence ID" value="BAJ62915"/>
        <property type="gene ID" value="ANT_08810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08810"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="OMA" id="EHIYHAA"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="194"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="466" mass="52492" checksum="B064AC1B395E52F1" modified="2011-04-05" version="1">MPKIAFIGAGSTVFAKNLLGDILSFPELADSTISLMDIDETRLNTTRLVAERIARTLGAHPTIEATTDRRKAVAGADYVITMFQIGGYRPSTVIDFEIPKKYGLRQTIADTLGIGGIMRALRTIPVLLDLAKDMEELCPQALLLNYVNPMAMNMWALNRASKIRNVGLCHSVQGTAMQIAQDIGVPIEEINYLCAGINHMAFYLKFERKTPQGVEDLYPRIHQVYKEGRVPDWNRVRYEMLKRLGYFVTESSEHFSEYVPWFIKRDRPDLIEKFNIPLDEYIRRCEVQIAGWEATKDVVENPNLPINVPLIQEKLRAAGATDWDINWITEIASKFDQIEKSHEYGSYIIHSLETGIPRVIYGNVENRGLIDNLPQGCTVEVPCLVDKNGIQPTKIGMLPPQLAALMQTNINVQALTVEAALTGKREHIYHAAMLDPHTAAELDLDQIWSLVDDLIEAHGDMLPPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A3</accession>
    <name>E8N3A3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559309.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08830"/>
    <dbReference type="EnsemblBacteria" id="BAJ62917">
        <property type="protein sequence ID" value="BAJ62917"/>
        <property type="gene ID" value="ANT_08830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08830"/>
    <dbReference type="eggNOG" id="COG4818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091700_0_0_0"/>
    <dbReference type="OMA" id="IVIARIW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="116" mass="12947" checksum="84C93D7442D2936A" modified="2011-04-05" version="1">MDRSRITAFLSYLILFLGSLYVLIFERRDDYARYHALQALGLVFFSAGVFLGWVVLGFLLAWIPIIGPVLSASLFALVIAAWIFAVVAWVMGMVNATRGLIAPLPLIGRWAEKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3D5</accession>
    <name>E8N3D5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559341.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62949">
        <property type="protein sequence ID" value="BAJ62949"/>
        <property type="gene ID" value="ANT_09150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09150"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373707_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="311"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="473"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="743" mass="84332" checksum="F50A3FA360BD8BAE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F7</accession>
    <name>E8N3F7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559362.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09370"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="BAJ62971">
        <property type="protein sequence ID" value="BAJ62971"/>
        <property type="gene ID" value="ANT_09370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09370"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_3_0"/>
    <dbReference type="OMA" id="LFEINGC"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="110"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="40021" checksum="34F702205ADA5024" modified="2011-04-05" version="1">MIHKLTGSSSPVSETPVREASSRLGVTYWLSWIPAVLMVAWLGYVVLLKVGVVEAARINLDRQVELAKVLPANAQSEAQLPDLTFTQPVSVSRVTELDTLVPSRPRTEPQKYVVQAGDSVFSIAKQFNLKPETVLWANYNLLNDNPNMLSIGQELVIPAVDGVLYEPKPGETIEDVAKKFKATPEDIISWPANKIDVADPKLVAGQTIMIPNGQREMRSWVVPTIWRANSGANKTVNAACDTSGVNVYGTGYFMWPADNHSISGNTFWSGHLGIDIAAAMGAPIYAADSGVVVYSGPIGGGYGLMVMIDHGNGFHTLYAHNSQLLVRCGQGVSKGQVIAYAGSTGNSTGPHLHFEIRYLGAFVNPLDYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J1</accession>
    <name>E8N3J1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559396.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63005">
        <property type="protein sequence ID" value="BAJ63005"/>
        <property type="gene ID" value="ANT_09710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09710"/>
    <dbReference type="HOGENOM" id="CLU_1599323_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="166" mass="17979" checksum="33028242632EB22E" modified="2011-04-05" version="1">MGILLGLPIVILLTIFQSVVVSNIPLLHGTADLVLLVLAALALQERISTIYEWAVMAGILMGLVSAVPWFIPVFGYVGTVALARFLKRQVWQTPVLAMLLTTLSGSVVMLGMQMLALQAQEVPISIVESIDLVILPAVFLNVLLALPVYALTIDLTRSVYPEEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K8</accession>
    <name>E8N3K8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsA</name>
        <name evidence="2" type="ordered locus">ANT_09880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63022">
        <property type="protein sequence ID" value="BAJ63022"/>
        <property type="gene ID" value="ANT_09880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09880"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_4_0_0"/>
    <dbReference type="OMA" id="YDYHFSP"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="174"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="259"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="36856" checksum="7E7D7E81614AC223" modified="2011-04-05" version="1">MVGIFYLNVIGVWRYEMAVRRSVARAEEEVEMPMDEGWWASVLADEQAYGESLVKTASAKSSGISGGVNWARARQYLENDEVVKLEVYGFNRGGLLVRGEDIQGFVPVSHLVEMPCVPADEEQRRQSLANYVGRILSLKVIECEMQAERIVFSERAALAGEGKRRQLFSTLRPGEIVNGTVTNVTDFGAFVDLGGLEGLIHVSELSWGRVQHPTDILQVGVPVRALVLSVSAENGRVALSLKRLCPNPWETLPQIYRPGDVVEAEVTAIMRFGAFARLKEGVEGLIHISTMSLPDGEKDIEKFMKIGQKVQVRILHLDAERRRLGLGLVQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Y3</accession>
    <name>E8N3Y3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559537.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11130"/>
    <dbReference type="EnsemblBacteria" id="BAJ63147">
        <property type="protein sequence ID" value="BAJ63147"/>
        <property type="gene ID" value="ANT_11130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11130"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_2_0"/>
    <dbReference type="OMA" id="ASITQDW"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="145"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="331" mass="36337" checksum="DAE5C20EE369E681" modified="2011-04-05" version="1">MTPVRVAMIGCGGMARYHLHQMLRQQHTTQVVALCEPSEEQFTATARIFEEAGLAVPPNEPDLQKLLETFELDAAFIITPHAYHFEQAKACLESGLDVLLEKPMVMNAQEAQDLIKVRDRTGKLLVVAFPGSLSPQVRQASAWLHSGKLGKILSISATVWQNWGPATVGTWRQDPALSGGGFLFDTGAHMLNTVVDLAGEEFSEVAAFLEHHGRPVETLGVVIGKLKSGALVTLHACGEAIPSCASNIYVFSQKAILRTGVWGEFLEIQREKEEKFHKVRVPTSLGVWEQFLAVRNGEIPNPCPPEVGLRMARLYDAIQRSASQNGQVVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Y4</accession>
    <name>E8N3Y4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bglA</name>
        <name evidence="7" type="ordered locus">ANT_11140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559538.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63148">
        <property type="protein sequence ID" value="BAJ63148"/>
        <property type="gene ID" value="ANT_11140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11140"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_0"/>
    <dbReference type="OMA" id="VEACDRK"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="407"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="448" mass="50907" checksum="0B4C5B75AC79E397" modified="2011-04-05" version="1">MIVKAFPQDFVWGVSTSAYQVEGAWNEDGKGESIWDRFCHTPYRIANGDTGDIACDHYHRMPEDVALMKELGVKGYRFSIAWTRIFPDGKGKVNPKGLDFYDRLVDELGKAGILANATLNHWDLPQALQDLGGWANRDTTDRFAEYARVMFDRLGDRVALWATHNEPVVVTSGYLGGSMAPGLADASVAYRVAHHLNLAHGKAVQVFRQGGYPGKIGIVLDLQNYIPESDSEADVLATQRMLDHSHHLFLDPIFKRQYPQGLMEWLGTIAPQPQEGDMEIISTPIDFLGLNYYFTLKVRYEPWGGLLKAAARPFSAPMWSQTEMGWGVHPEGLTAILLKLRNHYGNPDIYITENGTAAPDQPDEHGFVQDRERIAYLRRHLIAAHDAIQQGVNLRGYFVWSFMDNFEWALGYRPRFGIVRVDYATQKRIPKLSAYWYREVIRQNAVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Y5</accession>
    <name>E8N3Y5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Flavocytochrome MsrQ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">msrQ</name>
        <name evidence="9" type="ordered locus">ANT_11150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="7">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MsrQ family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559539.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63149">
        <property type="protein sequence ID" value="BAJ63149"/>
        <property type="gene ID" value="ANT_11150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11150"/>
    <dbReference type="eggNOG" id="COG2717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080662_0_1_0"/>
    <dbReference type="OMA" id="LHFFWMR"/>
    <dbReference type="OrthoDB" id="1508607at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01207">
        <property type="entry name" value="MsrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022837">
        <property type="entry name" value="MsrQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36964">
        <property type="entry name" value="PTHR36964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="209" mass="24311" checksum="306E2C4B109AF48B" modified="2011-04-05" version="1">MSSQRNGVLRILLHSVGLMPLIVLIVRWQINDLTINPIQAATRFTGDWALIFLLLSLACTPLSLLFKWRQALRFRRPLGLYAFLYASIHFLIYVWLDYDWAWNFILPSLKEKPFILAGALALFILLLLALTSFDFSPRWLGKHWKTLHRLVYLAGILVILHFAWASKGDLFRLSGEILRPLIAGVILFGLLILRLPPIRRFIQFFRSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N451</accession>
    <name>E8N451_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_11810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559603.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11810"/>
    <dbReference type="EnsemblBacteria" id="BAJ63215">
        <property type="protein sequence ID" value="BAJ63215"/>
        <property type="gene ID" value="ANT_11810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11810"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490630_0_0_0"/>
    <dbReference type="OrthoDB" id="10622at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="3">
        <location>
            <begin position="246"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="554" mass="61239" checksum="92FBBFCF7ACC0C07" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N453</accession>
    <name>E8N453_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_11830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559605.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11830"/>
    <dbReference type="EnsemblBacteria" id="BAJ63217">
        <property type="protein sequence ID" value="BAJ63217"/>
        <property type="gene ID" value="ANT_11830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11830"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251328_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="357"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="929"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="972"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="990"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1429"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="563"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1450" mass="161264" checksum="2B4EC57A8C21B636" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A2</accession>
    <name>E8N4A2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559654.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63266">
        <property type="protein sequence ID" value="BAJ63266"/>
        <property type="gene ID" value="ANT_12320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12320"/>
    <dbReference type="eggNOG" id="COG4898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133735_0_0_0"/>
    <dbReference type="OMA" id="HQVIEWL"/>
    <dbReference type="OrthoDB" id="1890756at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023204">
        <property type="entry name" value="SP1917_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014580">
        <property type="entry name" value="UCP033199"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09966">
        <property type="entry name" value="DUF2200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033199">
        <property type="entry name" value="UCP033199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="116" mass="13720" checksum="5A949255A0453A2D" modified="2011-04-05" version="1">MPNSQIFSMKFSDIYRLYIQKSERKNRKKEEVDQIICWLTGYDWIELHQQINQGCNLETFFTQAPSIHPNASLIKGKVCGVRVEDIEDPLMQKIRYLDKLIDELAQGKTMEKILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D0</accession>
    <name>E8N4D0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559682.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12600"/>
    <dbReference type="EnsemblBacteria" id="BAJ63294">
        <property type="protein sequence ID" value="BAJ63294"/>
        <property type="gene ID" value="ANT_12600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12600"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_13_1_0"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="68" mass="7622" checksum="7921F3497B6B4839" modified="2011-04-05" version="1">MQTVTYKIPNISCHHCVHTITSELSELPGVKEVKADKDTKIAVITFDAPATEEQIVATLREINYPPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D5</accession>
    <name>E8N4D5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aspS</name>
        <name evidence="9" type="ordered locus">ANT_12650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559687.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63299">
        <property type="protein sequence ID" value="BAJ63299"/>
        <property type="gene ID" value="ANT_12650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12650"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_0"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="142"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="534"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="593" mass="67419" checksum="A086D5C20E0D5687" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I9</accession>
    <name>E8N4I9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_13210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559740.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13210"/>
    <dbReference type="EnsemblBacteria" id="BAJ63353">
        <property type="protein sequence ID" value="BAJ63353"/>
        <property type="gene ID" value="ANT_13210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13210"/>
    <dbReference type="eggNOG" id="COG2403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046378_0_0_0"/>
    <dbReference type="OMA" id="ECTIEER"/>
    <dbReference type="OrthoDB" id="414225at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="441" mass="49246" checksum="841C248C28996189" modified="2011-04-05" version="1">MAPIRTIIMGAAGRDFHNFNVFFRGNPEYEVVAFTATQIPNIEGRVYPAELAGPKYPKGIPIYPESDLVRLIKELKVDQVVFAYSDVPHEYVMHKASTVLAAGADFRLMGTKATMLKSSKPVVAVCAVRTGSGKSQTTRRVSLILRELGYKVAAIRHPMPYGDLVKQAVQRFETYADLDKHECTIEEREEYEPHLDNGVIVYAGVDYEKILRQAEQEVDIILWDGGNNDFPFYVPDLYIVVADPHRPGHELAYHPGETNVRAADVFVLNKVDTARPEDVIKVRESLYAVNPNAIFIEAASPLFVENPGAIRGKRVLVVEDGPTLTHGEMAYGAGWVAARRFGAAEIVDPRPFAVRSILETYKKYPTTGAILPAMGYGEAQMKDLEETINRSDVDLVISATPIDLTRVIKVQKPIQRVRYELQEIGKPDLMDILSEKFGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K6</accession>
    <name>E8N4K6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="14">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">galT</name>
        <name evidence="17" type="ordered locus">ANT_13380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="14"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63370">
        <property type="protein sequence ID" value="BAJ63370"/>
        <property type="gene ID" value="ANT_13380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13380"/>
    <dbReference type="eggNOG" id="COG1085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_0_0_0"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 14" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="15">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="16">
        <location>
            <begin position="192"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 13">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAJ63370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="358" mass="41190" checksum="93062C231C016A96" modified="2011-04-05" version="1">MIFCVRGCFNMNFERPHRRLNLLTGEWVLVSPHRAKRPWLGQVEKIPPERLPQYDPDCYLCPGNKRSVGIQNPPYTGTFVFDNDFAALLLPEDRPESHTEGNLFIAEEENGICRVICFSPRHDLTIPEMSQEEVEAVVETWSDQTLDLGARPFIRYVQIFENKGAMMGASNPHPHSQVWATSHIPNQPAVELRQQEIYAQSHHSCLLCDYLKAEQSSGERIVCQNETFTALVPFWAIWPFEILVISNQHTGSLPELNAEQRKGLADILRQVTIRYDNLFEISFPYSMGFHQNPTDGQAYPFHHFHAHYYPPLLRSATVRKFMVGFEMLGMPQRDLTPETAAQRLRDLPALHYKNRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L7</accession>
    <name>E8N4L7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_13490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559768.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13490"/>
    <dbReference type="EnsemblBacteria" id="BAJ63381">
        <property type="protein sequence ID" value="BAJ63381"/>
        <property type="gene ID" value="ANT_13490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13490"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_11_0"/>
    <dbReference type="OMA" id="ACFSVAF"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="6"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="409" mass="44159" checksum="C08C2CF26526E2FC" modified="2011-04-05" version="1">MTKNKPLSSIFLVVFIDLLGFSLILPLLPYLAKSFSASEFQIGLLVASYALAQFIGAPFLGRLSDRFGRRPILLISIAGNAIGFFLLGIAQNLEMLFLSRILAGFTAANISVAQAYISDVTDAQSRARGLGLIGAAFGLGFILGPAIGGALSQFGYAYPAFAATGLSALNFLLVFSWLKESLTPERRQALNHQQRPPITLKAMLETLRRPYVGPLLHTRFFFGLAFSLFQTIFSLYALERFNLQARDTGYILAYVGVISVLTQGVFIGKLTRKFNEIQLMFVAILTMAFSLLAWGFAPSVPVLLITLLPIAMSGGILNTVINSALSKSVAPIETGGILGLSASLESLTRVIAPSLGTLLLQITSQSYGVFIGTAVPGLAAFVLLIWLGSYFWRMIYRVPPVVHSPSGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W7</accession>
    <name>E8N4W7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14530"/>
    <dbReference type="EnsemblBacteria" id="BAJ63481">
        <property type="protein sequence ID" value="BAJ63481"/>
        <property type="gene ID" value="ANT_14530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14530"/>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061980_1_2_0"/>
    <dbReference type="OMA" id="HAAHITE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="207" mass="23476" checksum="8FEBB76AF1E73A28" modified="2011-04-05" version="1">MMTTKSIIGAVVLAAGMSRRMGQPKQLLPWGKTTVIGQVVNVLQAAQVAQIVVVTGKSREQVEQTLKNTSAQCVFNPRYETSEMLTSLKVGISRLHDEVQAVLVVLGDQPQIQVSVVQGLIEQYRLGKGVLIVPSYQMRRGHPWLVDRSLWQEILQMDDERESMRNFLNHHAQDIVYYLVDTPSILTDMDTPEDYQQMRPVDERDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N514</accession>
    <name>E8N514_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low molecular weight protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_15000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559910.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63528">
        <property type="protein sequence ID" value="BAJ63528"/>
        <property type="gene ID" value="ANT_15000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15000"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_3_0"/>
    <dbReference type="OMA" id="TGSWHVG"/>
    <dbReference type="OrthoDB" id="2062716at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="159" mass="17969" checksum="1D87768FA666AF7E" modified="2011-04-05" version="1">MEHQNHRHKILFVCTGNICRSPMAEAIFQHLVKQAGVENHFEVASAATTSWEVGEPPHPGTLSVLKKHGIPINPTKRAVKITPRDLEYYDHILVMDSDNVRALKGFDKVQRLTHFAPPGSPQDIPDPYYTGDFDEVFDLIHASCQNLLKHFQKDDESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N567</accession>
    <name>E8N567_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15530"/>
    <dbReference type="EnsemblBacteria" id="BAJ63581">
        <property type="protein sequence ID" value="BAJ63581"/>
        <property type="gene ID" value="ANT_15530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15530"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_1_0"/>
    <dbReference type="OMA" id="RSEARCH"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="32032" checksum="68BCF54A80AFD67A" modified="2011-04-05" version="1">MGKKKPLLNLVLITGGSSGIGLALAKKFAELGSKIIIVGRNKDKLTRAMDEISRSFPDKSQEIIPLQADVSQHEIYIPLLMQTLDTVGVPDIVVNSAGITKPAFFNDISIEEFRKIIEVNYLGTVATIKATLPRMLERNSGHIVNISSVAGFIGTPGYTAYGASKFAIKGLTDALRLELLHTDVKVSIVYPPDTQTPMLEEENKIKPAVVKALSEAASPVSAEEVAQAILAGIVKQQYVIAPGKETALLHFLAGFLGWGPIYPIMDWMLRDAERKVASSPTKYAYNDVANPNQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N596</accession>
    <name>E8N596_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Ribonuclease H</fullName>
            <shortName evidence="5">RNase H</shortName>
            <ecNumber evidence="4 5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rnhA</name>
        <name evidence="7" type="ordered locus">ANT_15840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63610">
        <property type="protein sequence ID" value="BAJ63610"/>
        <property type="gene ID" value="ANT_15840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15840"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_6_2_0"/>
    <dbReference type="OMA" id="MQEIEIF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="19792" checksum="B7D158F3D01A43C1" modified="2011-04-05" version="1">MKPTVMKKVIIFTDGACIGNPGPGGYAAILIYGKNKKEITGGFRYTTNNRMELMAAIAALEALKEPCEVILYSDSNYLVENFSSGLVFRWREKGWKRNKKEPVENVDLWTRFIKNCETHRVSLEWVMGHQGIRENERCDFLARQTAKRNDLPADRAFEEGLTRSLEPTLLDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5F2</accession>
    <name>E8N5F2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_16400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63666">
        <property type="protein sequence ID" value="BAJ63666"/>
        <property type="gene ID" value="ANT_16400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16400"/>
    <dbReference type="eggNOG" id="ENOG5033RR4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515497_0_0_0"/>
    <dbReference type="OMA" id="MALVIND"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="528" mass="60581" checksum="B8A6C3DB7832A18F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K0</accession>
    <name>E8N5K0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63714">
        <property type="protein sequence ID" value="BAJ63714"/>
        <property type="gene ID" value="ANT_16880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16880"/>
    <dbReference type="eggNOG" id="ENOG5033JEV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010500_0_0_0"/>
    <dbReference type="OMA" id="IIMTREY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="123" mass="12774" checksum="44A33E686CAEC27D" modified="2011-04-05" version="1">MVFAPLPPESIRSGGNMINLGVEQFLMLMAVSLLVLGVISLAAGVLILTFRVGGKDIHTLASQTARMAQKGLADDIAGLVGNASALLEALNQLVRTTSGVGVFLILVGFMLFASAYSLVTMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5M5</accession>
    <name>E8N5M5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-xylose ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xylF</name>
        <name evidence="2" type="ordered locus">ANT_17130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560118.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17130"/>
    <dbReference type="EnsemblBacteria" id="BAJ63739">
        <property type="protein sequence ID" value="BAJ63739"/>
        <property type="gene ID" value="ANT_17130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17130"/>
    <dbReference type="eggNOG" id="COG4213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_13_0_0"/>
    <dbReference type="OMA" id="YTDGWLP"/>
    <dbReference type="OrthoDB" id="859573at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="42"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="375" mass="40875" checksum="D19564A416035FB6" modified="2011-04-05" version="1">MQRKLYRSLIVIVVIIMALTSLLGCSAPANTGGGGKTEKIKVGLSFSDFATERWKNEEQLMRKLLEEKGYEVLSQEANHDVKLQNDQVDNMVSQGVKALIIVPEDGDAIVTAVEKAAKAGVKVIAYDRLIKSTSIAAYISFNNVEVGRQQALGVMKALDIDNWDVASKGKARVVKLGGSPTDNNAILFRKGQDEILQKYIDEGKIEIVADQWVDNWDPANALKIMENILTAQKNDIDAVVASNDGTALGALQALKAQKLAGVVPISGQDATADGCNSIVKGELTVTILKDIRDLAPLAVDLADKLIKGEQIEGLKNYTMAELTNDPSKTGEVPCYFLPVSQVTKDNVYDLVVKSGFQKYDDVYRDIPEDQRPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q8</accession>
    <name>E8N5Q8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63772">
        <property type="protein sequence ID" value="BAJ63772"/>
        <property type="gene ID" value="ANT_17460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17460"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543640_0_0_0"/>
    <dbReference type="OMA" id="FKEMACA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="501" mass="56905" checksum="EC41401EB945409A" modified="2011-04-05" version="1">MKFLYQNYTGAFLLWCNSFVSGKLFLMKTAFQKQPGSVKIVLLMLLVLVTGCSTFLPEKSPATLTPSPIPITPSHQPQPTATITPEIPIEYRVEINDLRGSEILFLHPFVGAIDEQYQAWAEEFNQKNPYGITIKVESTGGLDTLPSMIQSRNPQVILTTPELLSQGLEEGWLAALDGYLTLPELGLSEAEQKNIHEEFWLQDRFSGAQSGFPALRTAIGLIYNTTWANELGYTHPPSTPQEFLEQACAAARENNRSAYLDKRGTGGWLLSTDSLHAIAWWYAFGAKVLPEKPGEKIQFEQNSVATTFQFLRDMQSQGCLWQGLNPSPYRYFSERYTLFYIGSLQDIPPQQAYHQSLARKDDWTLIPFPRQNQEPFFLSHGFSYGLLRTKPKLQMAGWLWIRWLADPSRQSTLTRLYQGMPLGNSSQNVFFDPILEKHFMHDASLIPLPGNPDWLIARRPVEDAFWQIFHLAEGQSVEEVMVELQSLTEYELSRTQATPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R3</accession>
    <name>E8N5R3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63777">
        <property type="protein sequence ID" value="BAJ63777"/>
        <property type="gene ID" value="ANT_17510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17510"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040029_0_0_0"/>
    <dbReference type="OMA" id="KRGTMFP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04742">
        <property type="entry name" value="NPD_FabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014179">
        <property type="entry name" value="PfaD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02814">
        <property type="entry name" value="pfaD_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="106"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="546" mass="60667" checksum="0DF0FB1EFE5E52DD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R8</accession>
    <name>E8N5R8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_17560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560160.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17560"/>
    <dbReference type="EnsemblBacteria" id="BAJ63782">
        <property type="protein sequence ID" value="BAJ63782"/>
        <property type="gene ID" value="ANT_17560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17560"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_0_0"/>
    <dbReference type="OMA" id="YFVAPYD"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="5">
        <location>
            <begin position="406"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="822" mass="91437" checksum="AA2D67D041E6D9C3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S0</accession>
    <name>E8N5S0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560162.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17580"/>
    <dbReference type="EnsemblBacteria" id="BAJ63784">
        <property type="protein sequence ID" value="BAJ63784"/>
        <property type="gene ID" value="ANT_17580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17580"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023504_0_0_0"/>
    <dbReference type="OMA" id="QSGHNSE"/>
    <dbReference type="OrthoDB" id="393364at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024749">
        <property type="entry name" value="Collagen-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025277">
        <property type="entry name" value="DUF4038"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12904">
        <property type="entry name" value="Collagen_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13204">
        <property type="entry name" value="DUF4038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4038" evidence="3">
        <location>
            <begin position="7"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen_bind_2" evidence="2">
        <location>
            <begin position="359"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="456" mass="52258" checksum="88B856D4BEA004F5" modified="2011-04-05" version="1">MKQIGTSKNQRFLVDEEEKPFFWLADTAWELFHRLSLAEITHYFEVRRRQGFNLIHAVLLAELNGLHVPNANGHISLCGDDPARPNEFYFRFVDEVVQLAEQYDLYVGLLPTWGDKVHGGLWGIGPVIFNEGNARAYGNFLGERYRRFKNVVWILGGDRSAEGYVAIWKSLAEGIIEGLGHKPLMTYHPMGGFSSSKWLHQQDWLSMNMLQSGHVLLDAPNWEMITRDLALQPVKPVLDGEPNYEDHPIDPYLREWEPKFGRFTDYDVRKQAYRSVFAGACGHTYGNHSVWQFWDLSREPVTHPMRVWQEAIFAPGAWQLTHLKSLMLSRPYFTRIPDQSLLPEEPTPPPVQEIQSDKENSARAAHSRATRAEDGSYAMVYIPQPDKKVIVDLSELAGTVQAWWYDPRTGKSFEIGVFSHHKIQQFTTPFSGPDWVLVLDEKSRKFGAPGTSQKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V3</accession>
    <name>E8N5V3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560195.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63817">
        <property type="protein sequence ID" value="BAJ63817"/>
        <property type="gene ID" value="ANT_17910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17910"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_6_1_0"/>
    <dbReference type="OMA" id="IRGIECH"/>
    <dbReference type="OrthoDB" id="1282433at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="224" mass="25928" checksum="29555F479CF95DD7" modified="2011-04-05" version="1">MMNNDMIFYGRRVLFLGAHPDDIELGCGALIAHIVPHTEIRCVTLSDNQKNPALKNLVEEHYRSMEVLGVPKEWVVLGPFETRRFPHYRQEILEYLLDWNRKFQPDIIFVHTKADIHQDHGTVTEEALRAFRGKTVLGFDVIRSSYGFFPSFLVEVSQQDVEKKIQALAEYKTYADKYYFNPEITRSTLIRNGAICERQYAEGFDILRIVGAFGCREMLTACES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5X1</accession>
    <name>E8N5X1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argF</name>
        <name evidence="9" type="ordered locus">ANT_18090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18090"/>
    <dbReference type="EnsemblBacteria" id="BAJ63835">
        <property type="protein sequence ID" value="BAJ63835"/>
        <property type="gene ID" value="ANT_18090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18090"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_0"/>
    <dbReference type="OMA" id="KYNGYEQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="172"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="288"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="331" mass="36422" checksum="C3EFA95A82C5491B" modified="2011-04-05" version="1">MKGVFPYVILPADSTTLSETGVVMKKDFISIQDYTPEELQSMLDLAIQLKKEYFSGGNPPLLKGKVLGMIFQKPSLRTRVSFDMAMRHLGGDALYLSPNEIGLGQRESIADVARVLSGYVHAIMARVFAHEHVLELAKWSSVPVINGLSDYDHPCQAMADALTIIEKFGTLKGVNVTFVGDGNNVCVSLMHIVTKLGGNFTHSGPEGYDMPKQAVELGLQFASKSGSKVRFTRDPHEAVRDAQVIYTDTWTSMGQEAEAKEREKVFPPYQVNEQLVSEADKDCIVMHCLPAHRGQEITDAVADGPHSAIFPQAHNRLHAQKAILVRLFQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y2</accession>
    <name>E8N5Y2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_18200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560223.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18200"/>
    <dbReference type="EnsemblBacteria" id="BAJ63846">
        <property type="protein sequence ID" value="BAJ63846"/>
        <property type="gene ID" value="ANT_18200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18200"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_0"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="359" mass="37554" checksum="C4EBEE05F689F3F3" modified="2011-04-05" version="1">MASAVTKEAVLQALSHVQEPELHKDLVTLGMVRDVEIEAGKVRFRIVLTTPACPLKSRIENEARSAVLSLSGVQEVEVILDAQVPSDGRNRGVLSLPVRNVVAVASGKGGVGKSTVAVNLAVSLAQSGARVGLLDADIYGPNIPTMMGVQRLPPQNGQKLIPAEAYGVQVMSIGFLVKPGQPLIWRGPMLHSAIRQFLADVAWNELDYMIVDLPPGTGDAQLSLAQSVPLSGGVIVTLPQRVSQEDAMRGLQMFRELNVPVLGVIENMSYLELPDGTRMDIFGTGGGEDLAQAAEVPFLGAIPIDPGVRVGGDQGVPVVISAPQSAPARALTAIAQKIAASLSVAALSAPGTLSINVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y5</accession>
    <name>E8N5Y5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">NADH-quinone oxidoreductase subunit C</fullName>
                <ecNumber evidence="8">7.1.1.-</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">NADH dehydrogenase I subunit C</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">NDH-1 subunit C</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">NADH-quinone oxidoreductase subunit D</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">NADH dehydrogenase I subunit D</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="9">NDH-1 subunit D</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">nuoC</name>
        <name evidence="9 12" type="synonym">nuoD</name>
        <name evidence="12" type="ordered locus">ANT_18230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560226.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18230"/>
    <dbReference type="EnsemblBacteria" id="BAJ63849">
        <property type="protein sequence ID" value="BAJ63849"/>
        <property type="gene ID" value="ANT_18230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18230"/>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_3_2_0"/>
    <dbReference type="OMA" id="TFAECIE"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8" id="KW-0874">Quinone</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="10">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="11">
        <location>
            <begin position="333"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="11">
        <location>
            <begin position="505"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="581" mass="66342" checksum="F97C1E16977FC164" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N620</accession>
    <name>E8N620_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560261.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18580"/>
    <dbReference type="EnsemblBacteria" id="BAJ63884">
        <property type="protein sequence ID" value="BAJ63884"/>
        <property type="gene ID" value="ANT_18580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18580"/>
    <dbReference type="eggNOG" id="COG4991">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1318717_0_0_0"/>
    <dbReference type="OrthoDB" id="2011635at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228654" description="SH3b domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="50"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="208" mass="21983" checksum="2B7DA754A87CDA03" modified="2011-04-05" version="1">MNRQKAFVTFSLLLFILLLFLLSIPQSALANDVAQLPTVAIPTVTSTPSGPMAIVVPGSETQINLRSGPGMFYDKVGVLLVGQKVPAKGKSPGGAWILVEYPGVQGGQAWVFANYVRIDPPRELPVVEIPPTPTPQVTNTIDPTLAAKFIVTVAPTRLPTYTPPPPLNVPTFQSQGSIAPAGIPMGLIILGCAALGVFFGLISFVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N626</accession>
    <name>E8N626_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hppA</name>
        <name evidence="11" type="ordered locus">ANT_18640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18640"/>
    <dbReference type="EnsemblBacteria" id="BAJ63890">
        <property type="protein sequence ID" value="BAJ63890"/>
        <property type="gene ID" value="ANT_18640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18640"/>
    <dbReference type="eggNOG" id="COG3808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_0"/>
    <dbReference type="OMA" id="MATTAMQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="764" mass="81253" checksum="81558BE9AA1B98D0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A2</accession>
    <name>E8N6A2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heme exporter protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ccmB</name>
        <name evidence="13" type="ordered locus">ANT_19400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CcmB/CycW/HelB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560339.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63966">
        <property type="protein sequence ID" value="BAJ63966"/>
        <property type="gene ID" value="ANT_19400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19400"/>
    <dbReference type="eggNOG" id="COG2386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079069_0_0_0"/>
    <dbReference type="OMA" id="VKCLAHW"/>
    <dbReference type="OrthoDB" id="1886257at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003544">
        <property type="entry name" value="Cyt_c_biogenesis_CcmB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026031">
        <property type="entry name" value="Cyt_c_CcmB_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30070">
        <property type="entry name" value="PTHR30070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03379">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002764">
        <property type="entry name" value="CcmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="225" mass="24590" checksum="A03D32DF0AD39A90" modified="2011-04-05" version="1">MKGFLRAMLAVLWKDLAAEMRSRELLSAMLVFALLVIFIFNFALDLEPATRASITSGVLWVTFIFAGTLGLNRSLAIEKDRGCLDGLLLAPVDRAAIYFGKTAANMIFMLVVAAIVLPVYSIFYNVNLVARPGLLLVILLGAEGYTAIGTLLATMAVQTRTRDMLLPILLFPVVIPVLVAAVKASAGFLQALPFEEIQPWLNLLVTYDVVFTAIAFMVFDSIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C4</accession>
    <name>E8N6C4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560361.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19620"/>
    <dbReference type="EnsemblBacteria" id="BAJ63988">
        <property type="protein sequence ID" value="BAJ63988"/>
        <property type="gene ID" value="ANT_19620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19620"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726925_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="43574" checksum="F8A6DC20AF55A30E" modified="2011-04-05" version="1">MNDLDKTREQLVTELIKAREHISRLQRQLIDYQSRDIAYPEMMVQSIPDGILLFDKEGYLAEAKPSQDPLLGTLFPIEHLIGHQYSDFFPDDLTEKFTETVSRARKAPQLLQSFLYEAQSPDGLRVRVEFWVKVFPGGSIACSFRPSALEHPQEKQENVRESALFRNLLDITRQLLNQPDPSRFWQVFTELIHQHLGLYLTRMYLYQAEHETLSLIASQGDITTDTSLTFPITSRYPAVRAYKQQQTLLIANPASETNIPPHILLPGMKRMLEIPLEGLGALELVSEQNQVFSEEEQFLLTTLTQIAQAVWKVLVEKDALAKQKEFYFLEKEIKARIQQTRSIDEALQVALQELSKALGFERAEIRLSLTPDGKATSTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG3</accession>
    <name>E8MXG3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560414.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20180"/>
    <dbReference type="EnsemblBacteria" id="BAJ64044">
        <property type="protein sequence ID" value="BAJ64044"/>
        <property type="gene ID" value="ANT_20180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20180"/>
    <dbReference type="HOGENOM" id="CLU_514513_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="529" mass="60254" checksum="74056436C8B4CD6D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR2</accession>
    <name>E8MXR2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_21170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21170"/>
    <dbReference type="EnsemblBacteria" id="BAJ64143">
        <property type="protein sequence ID" value="BAJ64143"/>
        <property type="gene ID" value="ANT_21170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21170"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_0"/>
    <dbReference type="OMA" id="NQVTDMI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="102"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="300" mass="34624" checksum="C7952E4BF976DA12" modified="2011-04-05" version="1">MPLLSYCIDEFLEFKRAQRLSRWTLLDYETVLRRFNREIGDFDIDHIERKTIAHYLASLDLSKKRVKNIYTALSSLWTWAVEMGYCTVHIIRQIKPPKPEKRPILPFTRDQIMNMLASTDASKEYTRPGKRACRNRLKTGVRDRAIILLLLDTGIRASELCGIKVKDIKPHGIYIHGKGSKDRLVPISETTRSALCDYIGEQKDIEKYVFKTEQGNVLSRDALRLIIRRIGDRAGVNDAHPHRFRHTFAINFLRNGGDVFTLQAILGHETLDMVRRYLAIAQTDINGVHQRASPVKVWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY05</accession>
    <name>E8MY05_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_22100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560605.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22100"/>
    <dbReference type="EnsemblBacteria" id="BAJ64236">
        <property type="protein sequence ID" value="BAJ64236"/>
        <property type="gene ID" value="ANT_22100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22100"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591197_0_0_0"/>
    <dbReference type="OMA" id="IAQICIF"/>
    <dbReference type="OrthoDB" id="2178566at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025383">
        <property type="entry name" value="MbhD-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13244">
        <property type="entry name" value="DUF4040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4040" evidence="8">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="167" mass="18326" checksum="ACE05362A1442CF1" modified="2011-04-05" version="1">MLDLLIGAGILFCAVKAMQENRLLVSALWLALTSALVSWMMYRVGAAEVAVVELSVGAGLVTVLFVFAINIAGDESLTRQSLVPRPLAWFAVVFSMGLLVWMIMPTLQSERMRAVLEQTGVLAGLFRSVLWEDRRVDTLMQVVLFFAGALAVLGLIGEQRKSHEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY12</accession>
    <name>E8MY12_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative succinate dehydrogenase cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sdhC</name>
        <name evidence="9" type="ordered locus">ANT_22170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22170"/>
    <dbReference type="EnsemblBacteria" id="BAJ64243">
        <property type="protein sequence ID" value="BAJ64243"/>
        <property type="gene ID" value="ANT_22170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22170"/>
    <dbReference type="eggNOG" id="COG2009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127125_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="145" mass="16429" checksum="3B8A1C61D9975E2D" modified="2011-04-05" version="1">MSGGVPMSSMKTTLEGYASYRGREGHWSFLLHRITGLGVVLFLAIHIVDTSFVYFAPQLYDEVLNVYRSTIFGLGEIALVFCLFFHGVNGLRIAYLDLFAPQNWTIEKTRRSTYVALIVTLVLWLPSAGYMLYKLLYHNYGLFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY44</accession>
    <name>E8MY44_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scpA</name>
        <name evidence="2" type="ordered locus">ANT_22490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560643.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22490"/>
    <dbReference type="EnsemblBacteria" id="BAJ64275">
        <property type="protein sequence ID" value="BAJ64275"/>
        <property type="gene ID" value="ANT_22490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22490"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_2_0"/>
    <dbReference type="OMA" id="YLVMAAM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="263" mass="29580" checksum="EE738F361AF4F29A" modified="2011-04-05" version="1">MSFQVAGFQTEGYRVQTPVYEGPLDLLLELIERAELDITTLALAQVTDQYLAYLSQLEDRDAAEVSAFLVIAARLVQIKSAALLPRPTVESHTSEEENPGEALARQLIIYKRFKELAEILGDREARNLRTYLRLSQPSVKVEAKLDLSGVSLEDLVQAARGIFISQPDLPALSKVVSKPRITIREKIQNILERLKKAGKTTFRSLISIRNDRLEWVVTFLAMLELVKRHIIQATQQELFGEIELSSNSEGVSAENIETEFIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY94</accession>
    <name>E8MY94_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpd</name>
        <name evidence="16" type="ordered locus">ANT_00050</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558437.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00050"/>
    <dbReference type="EnsemblBacteria" id="BAJ62039">
        <property type="protein sequence ID" value="BAJ62039"/>
        <property type="gene ID" value="ANT_00050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00050"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_2_0"/>
    <dbReference type="OMA" id="DAKYGEW"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="4"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="346"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAJ62039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="465" mass="49791" checksum="C66A1B54FE0BAB0B" modified="2011-04-05" version="1">MNEYDVIVIGAGPGGYVSAIRSAQLGLKTAIVDKQWLGGVCLNVGCIPSKSLLKNAEVAHTLRERGREFGFAFENLTLDYSVAVKRSRQVSDRLTKGVGFLMKKNGIDVHMGTARLTARDTVRVTDKDGKVTDLKAKNIIIATGASAAVIPGVKVDGEKVVTYWEAILQTRLPKSVIVIGGGAIGLEFSTVWNAYGSEVTIVEMLPRIAPLEDEEISAELTKAFQKRGINVLAGHRVQSVETTESGVRVVVSGESGEKTLEAEQALLAIGFKPNSRDLGLEEVGVKVNERGFIEVDERMATSVPGIWAIGDVTGKLLLAHVASAQGIACAEAIASLPVQPIDYRMIPRATYCQPQVASFGLTEAQAKEAGYSVKVGRFPFQPNGKALGLGDYTGFVKIIVDEKHGEILGAHMIGPEVTELLPELTLAQRSELTIEEVARNIHAHPTLSEVIMEAAEAALGHAIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA0</accession>
    <name>E8MYA0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_00110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558443.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62045">
        <property type="protein sequence ID" value="BAJ62045"/>
        <property type="gene ID" value="ANT_00110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00110"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="TFCARMY"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="34367" checksum="3161F7380E8F2ABE" modified="2011-04-05" version="1">METIIVEHLTHAFGERRALEDLSFTVGEGEVFALLGPNGAGKTTTVRLLNGLYRATAGSVRVLGLEPATQGEQVRAQTGVLTESPALYERLTARQNLRFFGEMAGMPAGELRRRMEELLEFFDLAERADERVATFSKGMKQRLALARALLNRPKILFLDEPTAGLDPEASRQVRELIASLRRENGQTVFLCTHILTEAERLCDRVLILHQGRALAVGSLAELQQRFNPGVWVEVQLLEPRAIAPGDLTPALQVQAQDALLRVQVSRLEDIPTLIHRLAGLGTPILRVEPLRPSLEEIYFKLQDQAEGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB0</accession>
    <name>E8MYB0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558453.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62055">
        <property type="protein sequence ID" value="BAJ62055"/>
        <property type="gene ID" value="ANT_00210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00210"/>
    <dbReference type="HOGENOM" id="CLU_2550945_0_0_0"/>
    <dbReference type="OrthoDB" id="2102938at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="82" mass="9246" checksum="A1F6A5E2986DE2C5" modified="2011-04-05" version="1">MAKRVWQTIKVQYCRHVGREVSLEAEVIYPDEHLPDEKPRIVAHRCSRGAECGLLSEAACIWAGTNPDVDPFAEKPDTPETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC6</accession>
    <name>E8MYC6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558469.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00370"/>
    <dbReference type="EnsemblBacteria" id="BAJ62071">
        <property type="protein sequence ID" value="BAJ62071"/>
        <property type="gene ID" value="ANT_00370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00370"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316570_0_0_0"/>
    <dbReference type="OMA" id="PNVGIYP"/>
    <dbReference type="OrthoDB" id="11085at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="921" mass="97030" checksum="7A64FC7F1819813F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN6</accession>
    <name>E8MYN6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ftsZ</name>
        <name evidence="9" type="ordered locus">ANT_23460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64372">
        <property type="protein sequence ID" value="BAJ64372"/>
        <property type="gene ID" value="ANT_23460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23460"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_0"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="207"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="387" mass="40914" checksum="49437E5EB2EE3A41" modified="2011-04-05" version="1">MDMNQPLSESFARIKVVGVGGGGCNAVNRMIEEGLQGIEFVAVNTDGQALMLSKADVRIRIGDKVTRGLGAGGNPEMGRKAAEESAEELYSALKGADMVFVTAGMGGGTGTGAAPIIAQIAKEVGALTIGVVTRPFTFEGARRAKSAEEGIGNLKEHADTLIVIPNDRLLQMVDKRASLQDAFRLADDVLRQGIQGISELITVPGLINLDFADVRAIMSEGGAALMAVGHASGEDRARIAAEMAISSQLLDITIDGARGILFNVTGGPDLTLFEVNQAAAIIKETAHPDVNLIFGAVIDPKIGDEIRITVIATGFDRSGVRPAAERPMRVENSQAPRPRPASTPAPVQPAPERPTPLQTPAPTEHDFSRVVNTDDFDIPAFLRNRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP1</accession>
    <name>E8MYP1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_23510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23510"/>
    <dbReference type="EnsemblBacteria" id="BAJ64377">
        <property type="protein sequence ID" value="BAJ64377"/>
        <property type="gene ID" value="ANT_23510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23510"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045984_0_0_0"/>
    <dbReference type="OrthoDB" id="1022097at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035328">
        <property type="entry name" value="DUF3048_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021416">
        <property type="entry name" value="DUF3048_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023158">
        <property type="entry name" value="YerB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11258">
        <property type="entry name" value="DUF3048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17479">
        <property type="entry name" value="DUF3048_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159774">
        <property type="entry name" value="SSF159774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228536" evidence="2">
        <location>
            <begin position="26"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048" evidence="3">
        <location>
            <begin position="86"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3048_C" evidence="4">
        <location>
            <begin position="256"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="421" mass="46750" checksum="5978B430640E6EE5" modified="2011-04-05" version="1">MEWRKKYPLVGLLLLVFLLSSCARATPSVFSPTATLVPVATLTPSPLPPTATLAPSSTPEPTATSLPDYPLEGYGPSGFPADVNPLTGLRVADPNLLNRRPVVIKVENLPREHRPQYGLSLADLVYEYYTEQGTTRFAAIFYGQDAEKVGPIRSGRFFDVNVVQMYRAVFIFGSAYSAVFERFANSDFAPRMVLENPQSCPALCRFEPQGRNFLMANTRELGAYLKTRNVDNSRQPLEGMYFNLQAPAGGETGEQVYVRYSGAIYNRWDYDPATGRYLRFVDAKDDVNRNNPQYVQLTDALTSQPIAADTVVTLCVPHEYFFKSTEIEVLDMKMDASAGSYRGCDGQIYSGGTGAAYVARDGKIYKAQWSRPKQDAPLTLLDEQGKPFPFKPGQTWFEVIGASSKVEKTDNGYRFTFAIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYR4</accession>
    <name>E8MYR4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">hisC</name>
        <name evidence="5" type="ordered locus">ANT_23740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560766.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64400">
        <property type="protein sequence ID" value="BAJ64400"/>
        <property type="gene ID" value="ANT_23740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23740"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_0"/>
    <dbReference type="OMA" id="IWLNANE"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="34"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="369" mass="41364" checksum="5E1F7651A64A2385" modified="2011-04-05" version="1">MLSPSPRFNDFPPYTPIEPFEVLSARMGIPMERIVKLDANENPYGPSPKVSKVLASLPFVHIYPDPESRALRERLAEFTGVPVENLMAGAGADELIDLILRVMLEPGDCVLNFPPTFGMYAFDTRLNAGQVVEIPRRADFSLDLERVLDAVRRYRPKVIFLTAPNNPDGQLPLPEEVEALLSTDALVVMDEAYVEFTSAGGRLGERLSRIRQVLERDNLVVLRTFSKWAGLAGLRVGYGAFPGWLLSVLWKAKQPYNVNVAANAAALASLQDLEGLAQNVEKIRQQRQELFEQLCAVSFLKPIPSEANFILCKVEGKEARAVKQALMQEGIFIRYYDTPLLRNYIRISVGRPQDHQALMDALRNLEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY6</accession>
    <name>E8MYY6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DICT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64472">
        <property type="protein sequence ID" value="BAJ64472"/>
        <property type="gene ID" value="ANT_24460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24460"/>
    <dbReference type="eggNOG" id="COG4250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1399950_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019278">
        <property type="entry name" value="DICT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10069">
        <property type="entry name" value="DICT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DICT" evidence="1">
        <location>
            <begin position="45"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="194" mass="22411" checksum="90F80FD0A54424FA" modified="2011-04-05" version="1">MDMAHLQPSDLFIQFFHKVLPAYTPQAETLLSQIAPEKLSALNFRYIFSVEKMIEISHMIEDAVMHSQRPADFHVSFQLFSRLGEQMPRYRAISQKVEKLWLYGVPDIPPMNLPNTEFIDTSNTPLTRYWFLVAYAPELSMTLVAEEISSPIPSSQRIYEGFYTFETDVAYKVLNLMHQIFPAQIPAPIPPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYZ7</accession>
    <name>E8MYZ7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B12-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558538.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01060"/>
    <dbReference type="EnsemblBacteria" id="BAJ62140">
        <property type="protein sequence ID" value="BAJ62140"/>
        <property type="gene ID" value="ANT_01060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01060"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495139_0_0_0"/>
    <dbReference type="OMA" id="MAIKPHI"/>
    <dbReference type="OrthoDB" id="297563at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="546" mass="60038" checksum="99FD80EF8AB3FA97" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ87</accession>
    <name>E8MZ87_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558628.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01960"/>
    <dbReference type="EnsemblBacteria" id="BAJ62230">
        <property type="protein sequence ID" value="BAJ62230"/>
        <property type="gene ID" value="ANT_01960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01960"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2217525_0_0_0"/>
    <dbReference type="OrthoDB" id="2088597at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="106" mass="11929" checksum="1B0579E47528EF2B" modified="2011-04-05" version="1">MTDEITPELFAHLVELAALELDAQEAEYLRRQLNYQLKAIHELEAIPLDEDTPITSHGVAYTPEISQPPRADEWHPYPAPQDILSQAPEVDDGYIVVPETPTTPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD1</accession>
    <name>E8MZD1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRISPR system Cms protein Csm5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CRISPR type III A-associated protein Csm5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_24530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This subunit might be involved in maturation of a crRNA intermediate to its mature form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated Csm5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560834.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64479">
        <property type="protein sequence ID" value="BAJ64479"/>
        <property type="gene ID" value="ANT_24530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24530"/>
    <dbReference type="eggNOG" id="COG1332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036878_3_0_0"/>
    <dbReference type="OMA" id="TPVHIGS"/>
    <dbReference type="OrthoDB" id="1989826at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010173">
        <property type="entry name" value="CRISPR-assoc_Csm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38007">
        <property type="entry name" value="PTHR38007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01899">
        <property type="entry name" value="cas_TM1807_csm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="379" mass="42093" checksum="22EB5E06BC6AF01C" modified="2011-04-05" version="1">MPEYALLELEVSTLTPLHIGTGVDLLHEYDYIVAGGKTWRINHGALLEAQDVDDPKQLDFLSRTPPARLLKPTDFTPQSPFFRYIMAGAPRATGEGAVLREQIKDVYDRPYLPGSSLKGALRTALASTLWKQANRTLNLTDLGFSARFAAQRYERELLGRDPNRDLLRALQVSDSQPVGSDRLMVLNARIINQRGKLGSPIEMEAIRSDTTFHMTVKVDLALFSEWAKRAGLTLPAESALMNLPGIVNARSRSLAKREEAWFAAVPGAGAVASFYRQIASVNLPAGQMFLPLGWGTGWESKTLGASLMQDPHLRETLLRKYSMTRGRRNKGDPFPLSRRVAMRVQKTPNGALQETLFLPLGWVLVSFKVVKGPQSVWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF3</accession>
    <name>E8MZF3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_24750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560856.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24750"/>
    <dbReference type="EnsemblBacteria" id="BAJ64501">
        <property type="protein sequence ID" value="BAJ64501"/>
        <property type="gene ID" value="ANT_24750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24750"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383613_0_0_0"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="19019" checksum="0ECC676D553E8655" modified="2011-04-05" version="1">MAVLKRLLIVLGLAITPLLVGLLFTYDIIKIEWISFMEIQPSFRTQEDPLPLPARSVPVQGAAYIPELGAPTNPVPADEASLQRGKTQYEINCQICHGATGRGNGPFAVFLQPRKPVSLLEGRPVTLSDGELFMTITNGVEGAMPSLIQNLPEPQMRWDVVNYVRSLQKQANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG1</accession>
    <name>E8MZG1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyclopropane-fatty-acyl-phospholipid synthase</fullName>
            <ecNumber evidence="2">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560864.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64509">
        <property type="protein sequence ID" value="BAJ64509"/>
        <property type="gene ID" value="ANT_24830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24830"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_6_2_0"/>
    <dbReference type="OMA" id="QAEWAQK"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="434" mass="49354" checksum="5F0A62AAE306B209" modified="2011-04-05" version="1">MVFSTVQEKTNARELTLSLLERLFPSNLLNGVGFRLWDDTRYPKDNVPASTTIVLNHPGALRAMLLPGTEVGLVEAYLYNDFDIEGNIEAVFPLGEALAERTNGWKKKLDIARELMRLPNQQNPRISKRGAARLSGKTHSIERDRQAVRYHYDVSNDFYSLFLGKRMVYSCAYFESPDEDLDTAQERKLDYICRKLRLKPGQKLLDLGCGWGGLVIYAAERYGVDVTGITLSEPQASLAQQRIAEAGLQAHARVRVQDYREVEEWEQYDALVSVGMFEHVGEKLLPVYFERAYRLLKPGGVFLNHGIARRAAEKGWDPQSFSNAYVFPDGELVPISTTLRAAEESGFEVRDVESLREHYALTLRRWVANLEAHHTQALQFVEESTYRVWRIYMSGSAHGFASGRLNVYQSLLVKPAQEGESKLPLSRKDWYIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG7</accession>
    <name>E8MZG7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monogalactosyldiacylglycerol synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_24890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560870.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24890"/>
    <dbReference type="EnsemblBacteria" id="BAJ64515">
        <property type="protein sequence ID" value="BAJ64515"/>
        <property type="gene ID" value="ANT_24890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24890"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028367_3_2_0"/>
    <dbReference type="OMA" id="HSYWIHP"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="241"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="422" mass="47286" checksum="FA0F169AC4C0613C" modified="2011-04-05" version="1">MENGERKRVLILTADAGFGHRSAALAIEAALQQKYGNLVETRVVNPLDDRRTPFFLRDSQADYDRLVRRVPELYKLGYDASDTIITSAIVESAITVLLYEVMLDLVRDAKPDVIVTTYPMYLSPLEAIFIMYGRDIPLVTVVTDLATVHRMWFSKAVDACLVPNEIVRDLAINYGLSPEQVYITGIPVNPALNRKEGKDKISLRRALGWREDLTTVLAVGSRRVDRLLDTLNVLNHFGAPLQLAVVAGKDENLYRQLQEVEWHVPVHLYEFVTNMPDMLLAADCVISKAGGLIVTESLAAGCPMMLIDVIPGQETGNAELVVSGGAGDLARSDREVLEVMAHWMMDNQRLLKERAKNAAAMGRPQAAFEVAELAYQFALRGPARHRHLFTRRTLIDLFNRNQVRWSRTEDLSTLSRSEDQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH5</accession>
    <name>E8MZH5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">pheS</name>
        <name evidence="15" type="ordered locus">ANT_24970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560878.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24970"/>
    <dbReference type="EnsemblBacteria" id="BAJ64523">
        <property type="protein sequence ID" value="BAJ64523"/>
        <property type="gene ID" value="ANT_24970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24970"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_0"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="76"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ64523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="343" mass="39040" checksum="63E959235CAFC0E5" modified="2011-04-05" version="1">MDELQELERIRREGLERLAEANDSASLEAWRVAYLGRNAPVMQVFSRLGQAPKELRPQIGQSANAVKQALEAAYQEKLEAVRRAALEEELTRQKLDVTLPGRRPFLGRHHIETQTMREILRIFTSMGFQVYSSPDIETDEYNFTYLNIPPHHPARDMWDTFYLTTPGLLLRTHTSPGQIHAMRQFAPEPVRVVLPGMCYRYEQAGARKDIQFTQVELLAVGYDITFADLKGTLQDFADRIFGERLRTRLRPSYFPFTEPSAEMDVECVICHGKGCSVCKGSGWLEIMGCGMVHPVVLQHGGYDPAKFTGFAAGMGPGRIAMLRHAIQDIRSLYENDVRFLEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI3</accession>
    <name>E8MZI3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaK</name>
        <name evidence="10" type="ordered locus">ANT_25050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560886.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64531">
        <property type="protein sequence ID" value="BAJ64531"/>
        <property type="gene ID" value="ANT_25050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25050"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_0"/>
    <dbReference type="OMA" id="DKMVLQR"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="631" mass="68317" checksum="2B50C21A88F7AE90" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP8</accession>
    <name>E8MZP8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_25700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64596">
        <property type="protein sequence ID" value="BAJ64596"/>
        <property type="gene ID" value="ANT_25700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25700"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_257785_0_0_0"/>
    <dbReference type="OMA" id="CDEFRIM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="1120"/>
            <end position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1349" mass="150193" checksum="7235BEF0A7B608EE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ3</accession>
    <name>E8MZQ3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560956.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64601">
        <property type="protein sequence ID" value="BAJ64601"/>
        <property type="gene ID" value="ANT_25750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25750"/>
    <dbReference type="HOGENOM" id="CLU_1318718_0_0_0"/>
    <dbReference type="OrthoDB" id="1032884at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="208" mass="24240" checksum="832708E5FF0CF78C" modified="2011-04-05" version="1">MSTLKPAFSLELNLIRVFLVLVSLLGFASQTTFWVIVAVVMDGLVFLSLYADLIWVDVLSNGLRLRRWIGKENTMTWDEVEEIQFNDLEIRLVGKGRKHRLTFPTQMRGLDDLIRNMLKRFPSAMWRPASMSQPVRLEGYTLIFSEGMSRQRYPLTAVRGLDLVEEYNFWSGVKFRSRVRLSGNQEHTFSGIQTFILLFNWTRKEPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU3</accession>
    <name>E8MZU3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_02440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="BAJ62278"/>
        <property type="gene ID" value="ANT_02440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02440"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_1_0"/>
    <dbReference type="OMA" id="FFCQGLT"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="313" mass="34246" checksum="8B1C8A2F7F14609F" modified="2011-04-05" version="1">MNEFWLTIISYAKLILLTIVPFVLAGQGTMLGGRTGIFNVAQEGIMLVGASVGFLVSFLTGSNALGMLAAMLAGGLFGLALAYFTTHLRMDQFVIGLALFFIGVGLSTLLPKIIIGVTLTPPLIPTLKDIPIPGLSQIPVIGEIFFKQNVLVYFSILLSIGLWWYLYRTQAGMELRAVGENPQAADSLGVNVPRARYWTAILGGMLMGLAGAYLPMVYTGTFTENMVKGRGWLAIALTFFGGWKPDTILYGALFFALIEVLAYRVQVLGTAIPYQFLLMLPYLATILVMMFSFRKARVPAFLGQNYDREKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW3</accession>
    <name>E8MZW3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ordered locus">ANT_02640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558695.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02640"/>
    <dbReference type="EnsemblBacteria" id="BAJ62298">
        <property type="protein sequence ID" value="BAJ62298"/>
        <property type="gene ID" value="ANT_02640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02640"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_0_0"/>
    <dbReference type="OMA" id="VIRMSVL"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="298" mass="31693" checksum="EFE059312783ACDF" modified="2011-04-05" version="1">MENTAQRSEWFINLLIKVSGYSSILFVTLILIFLLREGLPALGVTPLSNLFGERWYPIESYFGILPLMFGSLVVTVGALVIAIPFGVGTSVFISEIAPPWVNSVVKPLIEILAGLPSVVLGFLGIQVAAPLFREAFNLPTGLSAFTGAVLLALIATPTIVSITEDALNAVPPAYRQAALALGATKWQTIWGVTVPAARSGILTAVMLGIGRSIGETMAVMMVTGNAPVLPHGLSAIFMPVRTMTATIASEMGEVANGSPHYQVLFFIGIVLFLISLVINVAASWVSLRSRTRAERVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N007</accession>
    <name>E8N007_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558739.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62342">
        <property type="protein sequence ID" value="BAJ62342"/>
        <property type="gene ID" value="ANT_03080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03080"/>
    <dbReference type="HOGENOM" id="CLU_1297673_0_0_0"/>
    <dbReference type="OrthoDB" id="2187501at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="212" mass="23028" checksum="412E3B7F7F67F2F1" modified="2011-04-05" version="1">MAKFLMYVGVALASSGKRPTAFTALDARGHSLAIGTGTLADALAFAAGAGSALLVLTPPLRARTLRSAEPAPESPSLLPETSEESTPPLAATLQRVGYVNFSAEDESLRQWLETDAESAFERWLGHPPLPGNTLEGRIQRQLLLADLDCDVPDAMEFFEEITRFKLLRGQLPYEKILSLAELNAYAAAAIARLCDQSPDRVQHIQPRMFLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N061</accession>
    <name>E8N061_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_03620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558793.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03620"/>
    <dbReference type="EnsemblBacteria" id="BAJ62396">
        <property type="protein sequence ID" value="BAJ62396"/>
        <property type="gene ID" value="ANT_03620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03620"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306228_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="292"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="427"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="551"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="5">
        <location>
            <begin position="777"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="967" mass="110029" checksum="438D8F197264742F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N067</accession>
    <name>E8N067_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03680"/>
    <dbReference type="EnsemblBacteria" id="BAJ62402">
        <property type="protein sequence ID" value="BAJ62402"/>
        <property type="gene ID" value="ANT_03680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03680"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1891826_0_0_0"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="14446" checksum="CE8ED43546C8778B" modified="2011-04-05" version="1">MGSQGGMALSLMSWAGKALVALVFYCFFLGLGEELLFRGYLQSRLNQAFGKPFLFFGVAWGWGVVLSAALFGGMHLLNLGSLVSGHWQPAPWWGLWTFFAGLVMGFVREKSGGILAPVLLHGLPQALAEAVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0C1</accession>
    <name>E8N0C1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_26440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561024.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26440"/>
    <dbReference type="EnsemblBacteria" id="BAJ64670">
        <property type="protein sequence ID" value="BAJ64670"/>
        <property type="gene ID" value="ANT_26440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26440"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1308010_0_0_0"/>
    <dbReference type="OMA" id="WIAILPE"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="210" mass="23295" checksum="F70787ECEAE121A0" modified="2011-04-05" version="1">MDWIWLILSVLIGYLFGSISFARIIVRRLSPEVDLTQAAMPIQGVDDPMPLKTVSATTAGLMLGEKVGGVIGILDMLKAFIPVLVIRLIFSDQPYFLLTALSSTIGRNWPLYYRFQGGRGISTIYGGLLAIDWLGAVLTSVGGMLLGIAVLRDFALVFPLSLLLIIPWMGVRTGSLWYILYALGVNVLFWIAILPELKEVARIRRKRGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E6</accession>
    <name>E8N0E6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TsaA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561047.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64695">
        <property type="protein sequence ID" value="BAJ64695"/>
        <property type="gene ID" value="ANT_26690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26690"/>
    <dbReference type="eggNOG" id="COG1720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013458_2_0_0"/>
    <dbReference type="OMA" id="VCRLEIF"/>
    <dbReference type="OrthoDB" id="1535774at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="147" mass="16640" checksum="F3FD98B8C19847F0" modified="2011-04-05" version="1">MSLPILKAIGIIHSPYQQPQDTPIQSSRSTAEGWVEVFPEYAEGLEGIEGFSHLILLYVWHRAPSEVCLKVKPFLADFETGLFATRFPCRPNPIGISVVRLLERQGNRLHIHGVDVLDGTPLVDIKPYVPEFDVFSPERVGWYEQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G0</accession>
    <name>E8N0G0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561061.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64709">
        <property type="protein sequence ID" value="BAJ64709"/>
        <property type="gene ID" value="ANT_26830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26830"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_5_0"/>
    <dbReference type="OMA" id="ILHVHEG"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="210" mass="23694" checksum="736CC16018CC1A89" modified="2011-04-05" version="1">MGRVLYSVTFLRHGRSCADDEGVYEGRYDSPLTAVGEAQAYRRAREWKECGVTFDRVIASTLQRARRTAEIVCEVLNLPLETSEAWMEINSGKLAGMNPQEAERIYPRPAFRNPYETITPTGESEWQVFIRVAQALEEVIRQRVPRTLVVAHGGSLSMTLRVICGVTPWGNSQGVAFHLGDLGFARTAYDPQTNVWHFLELHPGLQEIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q2</accession>
    <name>E8N0Q2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_04130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558843.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62447">
        <property type="protein sequence ID" value="BAJ62447"/>
        <property type="gene ID" value="ANT_04130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04130"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_464359_0_0_0"/>
    <dbReference type="OMA" id="PYAQIEV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="379"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="587" mass="65901" checksum="069E37CFFEE2D757" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T0</accession>
    <name>E8N0T0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558871.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62475">
        <property type="protein sequence ID" value="BAJ62475"/>
        <property type="gene ID" value="ANT_04410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04410"/>
    <dbReference type="HOGENOM" id="CLU_356272_0_0_0"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="787" mass="87445" checksum="726E2E504661EF53" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U0</accession>
    <name>E8N0U0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 2-oxoglutarate ferredoxin oxidoreductase beta subunit</fullName>
            <ecNumber evidence="2">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62485">
        <property type="protein sequence ID" value="BAJ62485"/>
        <property type="gene ID" value="ANT_04510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04510"/>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_2_1_0"/>
    <dbReference type="OMA" id="SAWIASP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="58"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="28520" checksum="69296B0E36FB03E1" modified="2011-04-05" version="1">MVMEQILPEEIVYQRPEALADVNTHYCPGCTHGVAHRLIAEVIDEMGIRDRMVGVASVGCSVFAYNYFDFDWVQAPHGRAPAMATGIKRVLPDRFVVTYQGDGDMASIGMAEVVHAAARGENITVFFINNANYGMTGGQMAPTTLPGQRTTSSPSGRDVETAGYPIRAAELLATLEGASYVVRRSLHDPKNIRLAKKAIRTALEVQAQGLGFSMVEFLSTCPTNWGMTPVDALHWLEEHMIEYYPLGDFKVAPTVAQIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z1</accession>
    <name>E8N0Z1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62536">
        <property type="protein sequence ID" value="BAJ62536"/>
        <property type="gene ID" value="ANT_05020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05020"/>
    <dbReference type="HOGENOM" id="CLU_3246431_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="42" mass="4975" checksum="202175C0F3B296C1" modified="2011-04-05" version="1">MLNCSVLRRDFDHAEEVIRKADSEAFITAEEVRAVHRGFWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N164</accession>
    <name>E8N164_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561154.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27810"/>
    <dbReference type="EnsemblBacteria" id="BAJ64807">
        <property type="protein sequence ID" value="BAJ64807"/>
        <property type="gene ID" value="ANT_27810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27810"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OMA" id="AYDCIDV"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="36933" checksum="2C902941DF25CE11" modified="2011-04-05" version="1">MQYVRLGNTGLKVSRICLGCMSYGQPTEQWKWALNEEESRPFIKRALDLGINFFDTANVYASGMSEVVVGKALREMVSRDEVVIATKVFFPMGTGPNDRGLSRKHIFSAIDASLKRLGTDYVDLYQIHRWDYETPIEETLEALNDVVRAGKARYIGASAMYAWQFAKALFTSDLHGWARFVSMQNHYNLMYREEEREMIPLCRDQGIGIIPYSPLAKGRLARKPTSEEAKTMRAQTDEYGNRLYANEDPTIIYRVAEVAEKRGLPMAQVALAWMLAKPYITAPIVGATKLEQLEQAVGALEVQLTPEEIQYLEEPYQPHRILGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A3</accession>
    <name>E8N1A3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561192.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64846">
        <property type="protein sequence ID" value="BAJ64846"/>
        <property type="gene ID" value="ANT_28200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28200"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058803_0_0_0"/>
    <dbReference type="OMA" id="VWFGVEE"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225383" evidence="1">
        <location>
            <begin position="29"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="346" mass="37146" checksum="7D8C1D93F06F46A4" modified="2011-04-05" version="1">MTKHFRYFLFATGLCLALLLAVSQPARSAPDEPVWQSLGLSGQTIFALAAHPTDAQTLFAGVEQGGVYRTTDDGAHWTALTEGMGAADVLSLAVDPQTPATLYAGTAQNGAFRSQDGGEHWMALPLSSPFLYEWLVDPQTPSTLYVLANHALVKSLDKGDHWQACGQGVTSSSLTDLEMNPSNPSELFVGTMTGMVYHTTDGCASWTSALVSMDGVSALAVHPRFAGWVYAATPKGEVFLSQDYGKQWEKIGALPEQSPLHVLEVHPDVPSMLVAGTLTRGVYRSLDGGRTWTAVNTGLSSFTVRALIPDALNPNRWYAGTDDGVFALTFPTLSPQVYLPWIARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H3</accession>
    <name>E8N1H3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rbsC</name>
        <name evidence="7" type="ordered locus">ANT_05440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558974.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05440"/>
    <dbReference type="EnsemblBacteria" id="BAJ62578">
        <property type="protein sequence ID" value="BAJ62578"/>
        <property type="gene ID" value="ANT_05440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05440"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="OMA" id="FDVWNKR"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="321" mass="33311" checksum="E72734B5D64AB7F3" modified="2011-04-05" version="1">MSQVASRPVAFDRRAFFQRFGLVFSFLLLMIALSLLSERFLTPANLMNVLRQATINGIVSVGMTIVILTGGIDLSVGSVLALSVTVGASLMKQGTPVGLAVASALGIGTLLGVINGLMITRAKIPPFIATLGMLTVARGLTLLYTQGQPITGLPATFRWIGTGVVAGIPMPVILSLAVFALGWVFLSRTKYGAQIYLLGDNPTAARLAGVPVDRMTVLVYAISGFCAALAGLVLVARLDSAQPIIGQGYEFNAIAAVVVGGTSFSGGEGGLAGTLLGALLIETLNNGLNLLNVSPLWEQVVKGVVIALALLLYKVFSPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K0</accession>
    <name>E8N1K0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carbon monoxide dehydrogenase large chain</fullName>
            <ecNumber evidence="2">1.2.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.99.2" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559000.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05710"/>
    <dbReference type="EnsemblBacteria" id="BAJ62605">
        <property type="protein sequence ID" value="BAJ62605"/>
        <property type="gene ID" value="ANT_05710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05710"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_0_0"/>
    <dbReference type="OMA" id="THLCAVE"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="782" mass="85536" checksum="EA7156002AEE0E6D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K3</accession>
    <name>E8N1K3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559003.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05740"/>
    <dbReference type="EnsemblBacteria" id="BAJ62608">
        <property type="protein sequence ID" value="BAJ62608"/>
        <property type="gene ID" value="ANT_05740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05740"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_2_0"/>
    <dbReference type="OMA" id="GLHLITF"/>
    <dbReference type="OrthoDB" id="1616572at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="287" mass="31592" checksum="8D10A0832900FBB5" modified="2011-04-05" version="1">MILVSGAAGKTGLAVTRALSTRGKRVRAWVRCEAYRQRALGQGAAEVVVGDLRNPQDWQNALHGVEAVYHICPNMSPDEESIAAAMLEELCRLEGVQLVYHSVLHPQVEAMPHHWAKMRVEERIFASGVPFTILQPSAYFQNLLAFRQSILEQGCLSIPYSVQARLSMVDLQDVAEAAAQVLCEDGHAGAIYELAGPQPVSHEQVAQSLSRLLRRPIQAQTIPLEDWVKQAQRAGMSAYAVETLAKMFAYYDAHGLIGNARVLTCLLGRAPVSLEEFLSREFSSQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M7</accession>
    <name>E8N1M7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na(+)/H(+) antiporter subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mrpF</name>
        <name evidence="10" type="ordered locus">ANT_05980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559027.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05980"/>
    <dbReference type="EnsemblBacteria" id="BAJ62632">
        <property type="protein sequence ID" value="BAJ62632"/>
        <property type="gene ID" value="ANT_05980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05980"/>
    <dbReference type="eggNOG" id="COG2212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125825_1_2_0"/>
    <dbReference type="OMA" id="VIAFARY"/>
    <dbReference type="OrthoDB" id="2083248at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007208">
        <property type="entry name" value="MrpF/PhaF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34702">
        <property type="entry name" value="PTHR34702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04066">
        <property type="entry name" value="MrpF_PhaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028784">
        <property type="entry name" value="MrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0050">Antiport</keyword>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="87" mass="9630" checksum="EB568A4DCD21FAFE" modified="2011-04-05" version="1">MIMDWMWTLVIGLIGLAFIFTVIRLIRGPRLPDRVVALDLITAEIIGVIAVASVRANQPAFLDVAIILALISFLGTVAFAYYIEQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P3</accession>
    <name>E8N1P3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06140"/>
    <dbReference type="EnsemblBacteria" id="BAJ62648">
        <property type="protein sequence ID" value="BAJ62648"/>
        <property type="gene ID" value="ANT_06140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06140"/>
    <dbReference type="HOGENOM" id="CLU_383883_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045691">
        <property type="entry name" value="DUF6056"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19528">
        <property type="entry name" value="DUF6056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="720" mass="81158" checksum="EC2D5ADDF601165E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1U1</accession>
    <name>E8N1U1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559091.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06620"/>
    <dbReference type="EnsemblBacteria" id="BAJ62696">
        <property type="protein sequence ID" value="BAJ62696"/>
        <property type="gene ID" value="ANT_06620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06620"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_4_0"/>
    <dbReference type="OMA" id="VVGRAMY"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="262" mass="29473" checksum="FDFD3192BFB6B91F" modified="2011-04-05" version="1">MSAILLDGQMVHYEVLGRGRPVIFLHGWIGSWRYWIPTMQAASIAYRAYALDFWGFGDSAKVPERYGLDGQVNLLRGFMDQMGIGRVALIGHGLGATVAVMFALRYPEVVDRVLAVAYPLDETRLHPRLRSQSPEELVDWLLERNSTTEPVRVEAAKTDPRAIQDSLEGLTTLEAREASQKLTCACLLVYGEKDPVVPAPSDEVFLGLPFQTHGIVFDQSGHFPILDESSKFNRLVMDFLSLGVGESPRMLQLKEEWKRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X5</accession>
    <name>E8N1X5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_28960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28960"/>
    <dbReference type="EnsemblBacteria" id="BAJ64922">
        <property type="protein sequence ID" value="BAJ64922"/>
        <property type="gene ID" value="ANT_28960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28960"/>
    <dbReference type="eggNOG" id="COG1814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_2_0_0"/>
    <dbReference type="OMA" id="GYIKTCV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="29922" checksum="2E11DF22BDB18DDC" modified="2011-04-05" version="1">MSFSKRLEDARKGFLKGDPELSAKAHDVQAIRRAMHHRERHASAGSEYIGSMVYGGLDGIITTFAVVSGVAGAGLKPEIIIILGLANVFADGFSMATGAYLSEKSEMELYERERQRESWEVEHFPEAEKEELRQLYLAQGYPEEDANQMVEIKARDKQRWVDAMMLEELNLLPADTKPLTSALVTFGAFVIAGLLPLMVFLLDWLLPFSLSGQSAFWISVGVSGLALFGLGAAKVLVTERPPLRSGLEMLLVGGLAAAVAYLVGMFLRSLGLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N223</accession>
    <name>E8N223_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561314.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29440"/>
    <dbReference type="EnsemblBacteria" id="BAJ64970">
        <property type="protein sequence ID" value="BAJ64970"/>
        <property type="gene ID" value="ANT_29440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29440"/>
    <dbReference type="HOGENOM" id="CLU_2566374_0_0_0"/>
    <dbReference type="OrthoDB" id="2227457at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228066" evidence="1">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="81" mass="8719" checksum="1B8D9BFBCDF3266C" modified="2011-04-05" version="1">MKNWRLWIGLAGLTLLLLSGCARTAQVAEPTAQSTPEVPPTAIPTPTPKVDYCLECHTDKDRLIDTAKPEEEVVSESEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N240</accession>
    <name>E8N240_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561331.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64987">
        <property type="protein sequence ID" value="BAJ64987"/>
        <property type="gene ID" value="ANT_29610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29610"/>
    <dbReference type="HOGENOM" id="CLU_2406927_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="92" mass="10401" checksum="5EC7E2678F64891E" modified="2011-04-05" version="1">MKRPRWIVGAWLLVNLIGLAALGLGWMALNDIFHDYVSPQVLAEVGIEASPPEWTQTSGEWSMVLITWAFLLALMALNVLIAGWFFLRRPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N241</accession>
    <name>E8N241_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_29620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561332.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64988">
        <property type="protein sequence ID" value="BAJ64988"/>
        <property type="gene ID" value="ANT_29620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29620"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_0"/>
    <dbReference type="OMA" id="YHFYPGS"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="77"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="41247" checksum="A1093384DB4CA058" modified="2011-04-05" version="1">MTALAEILDRLTVPGELYEPQPEGAVRCVACAHRCLIKPGRRGICQVRFNHEGQLRVPWGYVAALQVDPIEKKPFSHFLPGTDALTFGMLGCDFHCPYCQNWVTSQALRDPLSDSSIRYIEGITPEQMVNIALSQRCASIVSSYNEPLITSEWAVSIFKLAKQAGLACAYVSNGNATPEVLDYLAPYLDAYKVDLKCMQDRSYRQLGGVLQHVLDTIQMAHQRNLWVEVVTLLVPGFNDSNEELWEAARFLVSVSPDIPWHITAYHPDYKMDAPPTTAQMLKTAAEIGQEAGLRYVYAGNLPGRVGSLEDTHCPHCQRAVIRRRGYVILEYAITAEGKCPDCGTPIPGRWHANPQDVRLHGPGFPKPVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N260</accession>
    <name>E8N260_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561351.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29810"/>
    <dbReference type="EnsemblBacteria" id="BAJ65007">
        <property type="protein sequence ID" value="BAJ65007"/>
        <property type="gene ID" value="ANT_29810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29810"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707192_0_0_0"/>
    <dbReference type="OMA" id="TECLTYG"/>
    <dbReference type="OrthoDB" id="816674at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="392" mass="44617" checksum="A3EE23A44714E303" modified="2011-04-05" version="1">MALFETLTNRWYIPARTLPVYRDSDGVWHVTGFAEARAVLQGAVRQAGFKAETFERIPPQWRIEKPVLFQEGEPHREQRRLTAKFFSPATVRQRYIPLMERTAESILAEFQQKRRADLNEMAGMMATSVVAEVVGLTESPLPAMAKRLDRILHANLDIGLDLRRLPAYLNVQGLILSFYLRDVRPAIRARRAQPREDLISHLIAQGRRDREILVECITYGAAGMVTTQEFLCVAAYHFLRHPEMKEAFLQGDSERRRAILEEILRLEPVVGHLYRRAEQDLEISSEGQTVVIPAGALIDLHIMEINRDARALGEEPLAYNPERQTERGVSVSGMSFGFGPHRCAGEHLALTESEVFLSRFLALPGVRIEREPALGRNDTIEGYELRRFIVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A0</accession>
    <name>E8N2A0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30210"/>
    <dbReference type="EnsemblBacteria" id="BAJ65047">
        <property type="protein sequence ID" value="BAJ65047"/>
        <property type="gene ID" value="ANT_30210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30210"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559985_0_0_0"/>
    <dbReference type="OMA" id="HAFHEWS"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="294"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="497" mass="56658" checksum="7B162AC3AD43B591" modified="2011-04-05" version="1">MRRGKILQFFDILYPKRDHHVMENLRLFFQYNEPLFQFIYGLTFFVLGVAIALQARYSSRLEIARSLRWLAAFGFTHGLYVWGELFVPVQASYFPPLFMQGVHFLHLLLLALSYVCLFEFGLALLRPLRMGNTLRGLVAGWHILFTLLMVRAAFSTPFDLRSFHDHVEALAGYMIAFPGGLFAAYGLREQTYRLIAPLDAPQVVSMLRTAGITLALFGALRGLIPPPIQFFPGSWLNLRTFEDALGVPVLVFLVLLGGFLLFSMVRALEVFHVEMERTIEHMEQQQILQAERERIARELHDNTLQMAYTAGLLIDSARKLADADSPIAQRLERAVQALNEVIADLRRNMQDLHSPLGENNPRRAIRQLVDDPRFRTLVEIHLEDTLPEEWTLSPRHTAHLLAILQEALSNVVRHARATRVTLQLRQDEAGNTLLTLEDDGEGMPAQVREGYGLRNMRERARMMGGTLVLSNRSPEKGTRLMLIFPSDTLSSSERTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A5</accession>
    <name>E8N2A5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="1">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpm</name>
        <name evidence="1" type="ordered locus">ANT_30260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561393.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30260"/>
    <dbReference type="EnsemblBacteria" id="BAJ65052">
        <property type="protein sequence ID" value="BAJ65052"/>
        <property type="gene ID" value="ANT_30260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30260"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_1_0"/>
    <dbReference type="OMA" id="TEWNVAR"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="196" mass="21526" checksum="01E72C740153F38D" modified="2011-04-05" version="1">MSVILWLIRHGETDWNREGRWQGWRDVPLNATGLAQAEAMAEKLAVAGVTFHALYASPLRRALQTAQPAARRLGLEIRVDERLREIHQGAFEGLTHAEIAERYAAELDAIRRMPATASAPGGETVTQVAARLRAAADDLARRHAGQTVLVFGHGLALATLYCQAHGIPLEQAHLHIPRNGDILVVEWGEETSLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B3</accession>
    <name>E8N2B3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DnaB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559113.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06850"/>
    <dbReference type="EnsemblBacteria" id="BAJ62719">
        <property type="protein sequence ID" value="BAJ62719"/>
        <property type="gene ID" value="ANT_06850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06850"/>
    <dbReference type="eggNOG" id="COG3935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1160381_0_0_0"/>
    <dbReference type="OMA" id="NWRYIER"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034829">
        <property type="entry name" value="DnaD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158499">
        <property type="entry name" value="SSF158499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01446">
        <property type="entry name" value="DnaD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="1">
        <location>
            <begin position="143"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="228" mass="26683" checksum="D13EC64E941A6D97" modified="2011-04-05" version="1">MAFQGFPAGKVRMVPIPEPFFTELLPQVDHLGELQVILYALWYVSRMEAPIRFLAYQDFARDEMLMRTLGGPHQLEDALERAVQRGVFLRVLPEGKSLKEALYFLNTPRGRAAIEAIQRGEWHPESEPHPTVTLVVERPNIYRLYEDNIGPLTPLIADLLEEAEKTYPQTWIEEAFQIAVERNVRNWKYIQAILKSWQEEGRDGENRRSSEENRRRYVEGKYADFIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2E1</accession>
    <name>E8N2E1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/sulphate symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_07130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62747">
        <property type="protein sequence ID" value="BAJ62747"/>
        <property type="gene ID" value="ANT_07130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07130"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_7_1_0"/>
    <dbReference type="OMA" id="NFSICLM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="472" mass="51059" checksum="68008140E0207401" modified="2011-04-05" version="1">MHKPGNHTSLFQLPGVKPLVGVFLSVVAAVSIWFLPLHGLAPEGKKALAITLFTVIWWVFKIVPPAYSTLLMLMGYILLGVATPQEVFAIWTTPLMWLIIGSFLMATAVTKSGLAERVATFFIIRFAGSYLGLIILTYVLGFVLSFLIPHPFPRALLMMSLMRAVIQKSGVNATDAASLGFSVFVATTATSTILLTGDSTLNIATIGFSGLSVGWLDWAKYMAVPGILASVLMMLLYMAIFPQTDPVEIDRTSLILEQDKHGKMTRKEIITLIWVSMALVLWMTDSLHGIDPAWIALLVAVGLSLPKVGGVLDENDLMSGINWPILLFVVGAMAIGTVGRTTGLAQWLAGNLLPAKTPQNPYIFAALVGGVTMVIHMVLGSALACMSIMAPPMVHYAVSAGWSPLFPSLLVYTAVAIHYIFPFQHVTILLGQGDTGGYGSRQVLKYGVPLTLVTLIVLIPIEVTWWMVMGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K1</accession>
    <name>E8N2K1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_07730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559200.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07730"/>
    <dbReference type="EnsemblBacteria" id="BAJ62807">
        <property type="protein sequence ID" value="BAJ62807"/>
        <property type="gene ID" value="ANT_07730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07730"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569439_0_0_0"/>
    <dbReference type="OrthoDB" id="414703at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228623" description="CARDB domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="3">
        <location>
            <begin position="306"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="479" mass="50859" checksum="B3741F0878E3E044" modified="2011-04-05" version="1">MTKRFHLILLCSLLVMLIMPAGGVFAQTPAPVTDRPLVVINGYYLDKDTIAVGDSFNLFVELKNISATQDASNLILSFVNDSFLPQETGGVVALGLLPAGGDRTVTQRFLVSSNLAGQPVGTIPLNLTYTGPDGTQYSERFTITLQLKIYYRAAYTPTPTPTPTLAPVVRPQLVISGYQTDVNPLQPGSLFKLSLDVRNLGNADARAVTLVLGGGVSPDPSGTPQPGGLSGGGGDLSVFAPVGSSNLVYLGDVPAGASLSTTSDLVVNVSANPGAYTLKISFVYTDPKGMRLVDDQIITLLIYRLPVLEVNFYRDPGPLFAGQPNVLPIQVVNLGKSTVVLGNMTVSAEGAELQNNTVLVGALDPGGFYTLDTTFTPMQAGEMTIKVALNYTDDFNQPRQVEQIIPVTVQESAPIIEPGMPPEGGEVPVQPVQETFLQKVWRFIRGLLGLDSAPPQPVVPQGEMPVQEYESVPAPLKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K9</accession>
    <name>E8N2K9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559208.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07810"/>
    <dbReference type="EnsemblBacteria" id="BAJ62815">
        <property type="protein sequence ID" value="BAJ62815"/>
        <property type="gene ID" value="ANT_07810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07810"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028806_0_0_0"/>
    <dbReference type="OMA" id="YSSWCET"/>
    <dbReference type="OrthoDB" id="581898at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="entry name" value="PTHR21419"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="551" mass="59130" checksum="1DA3405AD48C7BC5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L8</accession>
    <name>E8N2L8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559217.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07900"/>
    <dbReference type="EnsemblBacteria" id="BAJ62824">
        <property type="protein sequence ID" value="BAJ62824"/>
        <property type="gene ID" value="ANT_07900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07900"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="MSHPGQL"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="229" mass="26294" checksum="0BE78EEE64637C6A" modified="2011-04-05" version="1">MSKTILIVDDQSSVRQLLQEYLTEQGYRVLTTTDGQSALYIARHENPDLILLDIMMPRMDGYQFLRQFRQERQTPVIIITAREEETDAVLGLDLGADDYIIKPFRMRELAARIRAILRRGEEHPDKQEILRAGEIILDETTHTVTVSGKPVSLTPIEFDLLATLMRSPGRVYTRAELVEILADSGFAGIDTTLNVHVRNLRLKIEPDPKNPRYIETIFGIGYRFRKPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P1</accession>
    <name>E8N2P1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-xylosidase</fullName>
            <ecNumber evidence="5">3.2.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xynB</name>
        <name evidence="5" type="ordered locus">ANT_08130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559239.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62847">
        <property type="protein sequence ID" value="BAJ62847"/>
        <property type="gene ID" value="ANT_08130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08130"/>
    <dbReference type="eggNOG" id="COG3664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028597_0_0_0"/>
    <dbReference type="OMA" id="FWWRGNV"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="490" mass="56459" checksum="581772F71275663A" modified="2011-04-05" version="1">MDTFHFHLHGDVQPLDRFFQNCIGSCHAYLTLREDWREHARLIQREIGFRAVRSHGIFHDLVGIYQIPWGGERVFNFQNLDKIYDFWLSIGLKPFVELSFTPRALASGDRTVFHYQANVTPPKDRGEWELLIRTFATHLIERYGLEEVQTWYFEVWNEPDLQGIFWTGSMEEYFDLYALTARTLKAVHPSLKVGGPATSRNMWVKEMLDYCAAHNVPIDFLSTHHYCADAAFEMGEFSGIHWRGQKAMLHDVQRTVQTVRQSAFPNLPVLYTEWNVSPIHEDVYGKDSEFTAAFVLQTVKDLSGLLEAYSYWAISDVFEESGPGLTPFSGKYGLVNLHGIKKPVYHAFHFLSQLYDEELVSDAPSLRVTRSPEGNVRLLTWNFVEPVNPDFHSDYPLSGGEREEEIVLEGLQGEYEITCYQVDREHGNAFRAWLAMGSPQYLTAAQVEQLKQTAEPSVCDHQRLILDGTLRIKHVLPPSGIRFYDIRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S6</accession>
    <name>E8N2S6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_30500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561417.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30500"/>
    <dbReference type="EnsemblBacteria" id="BAJ65076">
        <property type="protein sequence ID" value="BAJ65076"/>
        <property type="gene ID" value="ANT_30500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30500"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_0"/>
    <dbReference type="OMA" id="IPERECK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="295"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="581"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ65076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1157" mass="126877" checksum="0040DB1BC42997ED" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T0</accession>
    <name>E8N2T0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561421.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30540"/>
    <dbReference type="EnsemblBacteria" id="BAJ65080">
        <property type="protein sequence ID" value="BAJ65080"/>
        <property type="gene ID" value="ANT_30540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30540"/>
    <dbReference type="eggNOG" id="ENOG5033T0B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692025_0_0_0"/>
    <dbReference type="OMA" id="NQAYFAF"/>
    <dbReference type="OrthoDB" id="2110824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="429" mass="48276" checksum="804F1B26FAF8BCF1" modified="2011-04-05" version="1">MAVLEDALKTLWRVFLNTLMLGLSLVLITRADYLPLNFLEQVRAYTRWQEFNYEAWMLDALLLKGQMAGLSAPRYLTILDQRRVVFDYLDLIGEIQRLNREIALIYADPQVKDPQSASADLNRQLLEARAREERLAPLAEAVIQSQVSAVLAEMHLTTLGQPIPPVLYHVTPLPYALIVSPRDQIRQEANISLLPGLTLEQRVAIEDAVAQGLNRSTLVVGIGGVGVYPTMVMSTTDLNWLVEVVAHEWTHNYLTLRPLGMRYEASPEMRTINETTASLAGKEIGRRVIERFYPERVPPPPPPQPPAAPRDGEAPEPPAFNFNREMRITRVKVDALLAEGKIEEAEAYMEERRQFFWDHGYAIRKLNQAYFAFYGAYNDEPGGTGAAGEDPVGPAVRKLREQSPSLADFLKKIAQVTSFEDLQKMLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U1</accession>
    <name>E8N2U1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative plasmid maintenance system antidote protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561432.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30650"/>
    <dbReference type="EnsemblBacteria" id="BAJ65091">
        <property type="protein sequence ID" value="BAJ65091"/>
        <property type="gene ID" value="ANT_30650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30650"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140230_5_0_0"/>
    <dbReference type="OMA" id="GNSAKFW"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="98" mass="11139" checksum="5D739117D7E04552" modified="2011-04-05" version="1">MTREIPPIHPGEILLEEFLKPLGISQNALARALRVPPDRINAIVQGKRSITADTALRLARAFGTTPQFWLNLQARYDLDVAQDRLEEQIEREVLPLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U9</accession>
    <name>E8N2U9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30730"/>
    <dbReference type="EnsemblBacteria" id="BAJ65099">
        <property type="protein sequence ID" value="BAJ65099"/>
        <property type="gene ID" value="ANT_30730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30730"/>
    <dbReference type="HOGENOM" id="CLU_975369_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="30774" checksum="AEA22EFF90FF8F36" modified="2011-04-05" version="1">MFYFQREGNMPALLRQPVKRCNRLAYLCGDCREFCSKKIYNQAGGERPSRGTQTGVTARARREVCAPGWLDGLLDAVASETLPMNSYPVDERQAHVTSKSTPLWQTVFIWTAANALGIAASMPLSALISLVKPLTGLAGSAVVIGIPVGLMQWLALRRTARVSPLWIFTVFFGLVAVGWLAGLISFHDDEGILELSSLYALAGLIIGLLQWSLLFRHFRRSFWYPLSSALGLGLALWAVLVTNLVSVNGSLALALGILIYSVATGVALAHLPPASSPEPAPDQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B0</accession>
    <name>E8N3B0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Two-component hybrid sensor and regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_08900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559316.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08900"/>
    <dbReference type="EnsemblBacteria" id="BAJ62924">
        <property type="protein sequence ID" value="BAJ62924"/>
        <property type="gene ID" value="ANT_08900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08900"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_285083_0_0_0"/>
    <dbReference type="OMA" id="PPISEMA"/>
    <dbReference type="OrthoDB" id="44267at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="486"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="839"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="7">
        <location>
            <begin position="972"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1087" mass="122410" checksum="B0DC678E803046C5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F4</accession>
    <name>E8N3F4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative S1B family peptidase</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559359.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09340"/>
    <dbReference type="EnsemblBacteria" id="BAJ62968">
        <property type="protein sequence ID" value="BAJ62968"/>
        <property type="gene ID" value="ANT_09340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09340"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_0"/>
    <dbReference type="OMA" id="GPLFNQR"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="413"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="544" mass="57020" checksum="742C69EC5A59F7C0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K1</accession>
    <name>E8N3K1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine aldolase</fullName>
            <ecNumber evidence="6">4.1.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_09810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.5" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559406.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="SMR" id="E8N3K1"/>
    <dbReference type="STRING" id="926569.ANT_09810"/>
    <dbReference type="EnsemblBacteria" id="BAJ63015">
        <property type="protein sequence ID" value="BAJ63015"/>
        <property type="gene ID" value="ANT_09810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09810"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_1_0"/>
    <dbReference type="OMA" id="NKGGGAC"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="347" mass="38064" checksum="9C26B7813B873523" modified="2011-04-05" version="1">MINHFIDLRSDTVTHPTPEMRQAMAQAEVGDDVMGEDPTVNRLEELAAEKMGKEAGLFVPSGTMGNLTAILTHCGRGDEMIVGHLSHTYLFEAGGSAALGGVHPFVLQNQPDGTLRLEDLRHAVREDDPHYPTTRLIILENTHNRCGGVVLTPEYMRAVGTFAREKGLKLHVDGARIFNAAVALGVLAVDLVRDADSVTFCLSKGLCAPVGSVLCGSREFIARARRIRKQLGGGMRQAGILAAAGIVALEKMVERLAEDHRRARRLAEGLSSVKGLVVENPQPATNMVYVRLGDMVQQDAPQVAEELEKLGIKSHWVDSRRFRLVTHYWVNDEDISRTIHAFAQVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Q2</accession>
    <name>E8N3Q2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplQ</name>
        <name evidence="6" type="ordered locus">ANT_10320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559457.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63066">
        <property type="protein sequence ID" value="BAJ63066"/>
        <property type="gene ID" value="ANT_10320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10320"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_2_2_0"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="125" mass="13935" checksum="D17C56BF99B6FE66" modified="2011-04-05" version="1">MRHAVAGYKLGRSKGQRNSLRRTLINQLFTHERIRTTRAKALAIRGDAERLITLARNSSKGTDIDKVNARRRAAARLGNPATVRKLFDDIAPRYANRNGGYTRIVKLGPRLGDAAEMVLIELVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3R1</accession>
    <name>E8N3R1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ordered locus">ANT_10410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559465.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63075">
        <property type="protein sequence ID" value="BAJ63075"/>
        <property type="gene ID" value="ANT_10410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10410"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_1_1_0"/>
    <dbReference type="OMA" id="IEMLGFV"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="118" mass="13118" checksum="1E89A837BAC09FE2" modified="2011-04-05" version="1">MLTAWLYIGIFLVVAVLLPAVAIGLAGILAPKKPNPIKTSVYECGIEVAGPARVQIKAQYYIYALVFLVFDVEMVLLFPWAVAFKQLPLFAVFEGILFLLILLGGLLYAWRKGALEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3R5</accession>
    <name>E8N3R5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative NADH-quinone oxidoreductase chain L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_10450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559469.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10450"/>
    <dbReference type="EnsemblBacteria" id="BAJ63079">
        <property type="protein sequence ID" value="BAJ63079"/>
        <property type="gene ID" value="ANT_10450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10450"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_1_0"/>
    <dbReference type="OMA" id="ILASAWY"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="170"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="725" mass="79208" checksum="3FF6BDB7B557C2EB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S1</accession>
    <name>E8N3S1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559475.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63085">
        <property type="protein sequence ID" value="BAJ63085"/>
        <property type="gene ID" value="ANT_10510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10510"/>
    <dbReference type="HOGENOM" id="CLU_2299836_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="100" mass="10858" checksum="FE871D74239A9E1C" modified="2011-04-05" version="1">MSQTNAPKPDRSRYWLNLTLAGFAAQAGCVTLVIVLGAVLGGLWLDARFQTRPVMTLILVFASIPISLLVMFFIVRATTAKIKSNLKHQNGEEADIGKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S2</accession>
    <name>E8N3S2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">atpB</name>
        <name evidence="13" type="ordered locus">ANT_10520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10520"/>
    <dbReference type="EnsemblBacteria" id="BAJ63086">
        <property type="protein sequence ID" value="BAJ63086"/>
        <property type="gene ID" value="ANT_10520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10520"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_2_1_0"/>
    <dbReference type="OMA" id="HMATISH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="336" mass="37423" checksum="8C38748AE5CFEBBF" modified="2011-04-05" version="1">MERRQTLEKTVNRGPLGIRHRWWVLLFIILNIVAVIFVKPVQPHIQVAPENLTHEPLFTLPVIGEFYLTNTLVMLVLVLLVIFWLAYSVHRELKSGTLVPKGVAGLMEALVEILYNLTESSAGKYAKTIFPWFATILIFVLVGNLMKLTPIVETFGLVHEVKEGGHALQELLPGVVNILPGEVHEGETGYHIIPFFRGIPTDLNFTLALALISVVMTQVIGVRAQGGAYFYKFFNVLNLFKKPFFGAMDFLVGLLELISEFAKILSFAFRLFGNMFAGAVLLFLVGSLIPVFMQSFVVLFEVFVGLIQAFVFGMLTMVFMAQATRGHGGEHGEGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3T6</accession>
    <name>E8N3T6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="8">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">leuS</name>
        <name evidence="12" type="ordered locus">ANT_10660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559490.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63100">
        <property type="protein sequence ID" value="BAJ63100"/>
        <property type="gene ID" value="ANT_10660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10660"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_0"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1_2" evidence="11">
        <location>
            <begin position="226"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="424"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="661"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="586"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="818" mass="94119" checksum="5B9D8B76E2B8CE1A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W5</accession>
    <name>E8N3W5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_10950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559519.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10950"/>
    <dbReference type="EnsemblBacteria" id="BAJ63129">
        <property type="protein sequence ID" value="BAJ63129"/>
        <property type="gene ID" value="ANT_10950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10950"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_0"/>
    <dbReference type="OMA" id="QYMMITI"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="168"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="377" mass="42726" checksum="6C3B8609B3C7DF23" modified="2011-04-05" version="1">MTAATLPAKKSQARQVSQSYWSLVWWKFKKNRIAVIGGIILILMYFCMAVIPEFIAPYDLERKSSFTEARPQTIRFIDAQGNFSLRPFVYGLERKIDEQLRRRTYVENPQVKYYIYFFVKGDPYKLLGFIPWDRHLFGVDPSIKDAHIYIMGTDSNGRDFFSRIIYGGRLSLLIGLIGQFLTIILGSVLGAISGYYGGAIDMFVQRFTEFLNAFPDIPLFMALAAAIPKYWSPITVYFMLTLILAFVRWGGLARQVRGLILSLREREYVLAAKSAGASDSRIMFRHLLPGTMSHVIVIATLSIPGMILSETALSWLGLGLRPPLTSWGVLLQEAGTVYAIRFAAWQLWTIPFILATIMAYNMLGDGLRDAMDPYSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Y1</accession>
    <name>E8N3Y1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559535.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63145">
        <property type="protein sequence ID" value="BAJ63145"/>
        <property type="gene ID" value="ANT_11110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11110"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061796_1_0_0"/>
    <dbReference type="OMA" id="VDCKEAR"/>
    <dbReference type="OrthoDB" id="1169054at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="333" mass="37867" checksum="0B09033C4B3A365B" modified="2011-04-05" version="1">MPRPVTLFTGQWADLPFETICAKAKSFGYDGIEIACWGDHFDVERALSEDGYIQSRWDILEKYGLKCYAISNHLVGQAVCDRIDERHKSILPPRVWGDGREDGVRQRATEEMKMTARAAAKMGVKVVPGFTGSSIWQYLYSFPPNPPDLIDKGYAFFAEMWNPILDVFDEVGVRFALEAHPTEIAFDIASAERAVQAVGGRKAFGFNFDPSHFGYQGVDYVAFILRFGERIYHVHMKDVYWSDKPSEAGVFGGHLNFGDRRRYWDFRSLGRGKINFEEIIRALNAIQYQGPLSVEWEDSGMDREFGATEACAFVRRLDFAPSQVAFDAAFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Y9</accession>
    <name>E8N3Y9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase</fullName>
            <ecNumber evidence="3">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">dcd</name>
        <name evidence="5" type="ordered locus">ANT_11190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559542.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63153">
        <property type="protein sequence ID" value="BAJ63153"/>
        <property type="gene ID" value="ANT_11190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11190"/>
    <dbReference type="eggNOG" id="COG0717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_4_0_0"/>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="OrthoDB" id="1598407at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="78"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="107"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="184" mass="20850" checksum="04F8F8C41FB3A915" modified="2011-04-05" version="1">MGIKPDHWIRKMALEHGMIEPFVDHQVREGVISYGVSSYGYDIRVADEFKIFTNVYSAIVDPKNFDRASMVDFKGDVCVIPPNSFALARTVEYFRIPRNVLTICVGKSTYARCGIIVNVTPFEPEWEGFVTLEISNTTPLPARIYANEGIAQVLFFEADEPCEISYADKKGKYQKQQSIILPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N439</accession>
    <name>E8N439_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63203">
        <property type="protein sequence ID" value="BAJ63203"/>
        <property type="gene ID" value="ANT_11690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11690"/>
    <dbReference type="eggNOG" id="COG4698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1500552_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228164" evidence="1">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19416" checksum="13C5557278EBB586" modified="2011-04-05" version="1">MKKILLFFGLCITLSLACNLPQRVQPTLSSVSTPSTSLEGQLAQALNELATTGKVTLTITEEQIAAFVRQQSSTSENNLQNLQVDFQENRIRLTGTTSTGIMNSQVEVIFEPYVSAGALQMQVVSAKIGSLPLPEKTVNAISQVVNERIQQLTTIQGKPLNIEEVRVEDGQLSITGSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N444</accession>
    <name>E8N444_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component hybrid sensor and regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_11740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559596.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11740"/>
    <dbReference type="EnsemblBacteria" id="BAJ63208">
        <property type="protein sequence ID" value="BAJ63208"/>
        <property type="gene ID" value="ANT_11740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11740"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_51_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="321"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="534" mass="59946" checksum="A775B73CD0F69C63" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C1</accession>
    <name>E8N4C1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bidirectional hydrogenase E subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hoxE</name>
        <name evidence="7" type="ordered locus">ANT_12510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559673.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63285">
        <property type="protein sequence ID" value="BAJ63285"/>
        <property type="gene ID" value="ANT_12510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12510"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_0"/>
    <dbReference type="OMA" id="CHVQGAE"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028431">
        <property type="entry name" value="NADP_DH_HndA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43342:SF2">
        <property type="entry name" value="PTHR43342:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="168" mass="18468" checksum="C97C5212E12CE779" modified="2011-04-05" version="1">MVATTRKVNPPDGDRRWKIVEATMRRHGYASTALIETLHSIQETFGFVSREALNYVAESLNIPPAKVFGVATFYNLFNLNPVGEHVFSLCTGTACYVKGAGEIVDFMKEEFGLEPGQTTPDGKLTFMVARCVGACGLAPVMILDGEVVGKLGVEEMKAKIREWVNHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C2</accession>
    <name>E8N4C2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bidirectional hydrogenase F subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hoxF</name>
        <name evidence="13" type="ordered locus">ANT_12520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559674.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12520"/>
    <dbReference type="EnsemblBacteria" id="BAJ63286">
        <property type="protein sequence ID" value="BAJ63286"/>
        <property type="gene ID" value="ANT_12520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12520"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_0"/>
    <dbReference type="OMA" id="VATFYHH"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="12">
        <location>
            <begin position="443"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="538" mass="58615" checksum="1E3F9DA7EA6E3D7C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D9</accession>
    <name>E8N4D9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein CbiM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cbiM</name>
        <name evidence="9" type="ordered locus">ANT_12690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63303">
        <property type="protein sequence ID" value="BAJ63303"/>
        <property type="gene ID" value="ANT_12690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12690"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_0_0_0"/>
    <dbReference type="OMA" id="LLLMQPI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="8">
        <location>
            <begin position="235"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="315" mass="32706" checksum="4F2D9B0BCA6DDF8C" modified="2011-04-05" version="1">MNFSPVHMHIPDGFLSVPLSIVLWLISIAVIAVATRRVSQDLGEREVPVMGVLAAAIFAGQMLNFSVTGGTSGHLMGAALATILLGPWAAVLIMTCVVGIQALIFQDGGLLALGANLFNMAVIGPFVSYAVYRFLQRVSGGQKWGVFVGSFLAAWASIFIASLAVALQLALSGTSPANIALPAMGGIHALIGIGEGLITLGAVSLIYASRRDLLKLGEPQPKGSTLIWVGGTLLALLLAVLSPLASSHPDGLEWVAEQAGFLERASEPSFTLIPDYVFPGVSNEVLATIIAGVLGTLLVLGVALGVAYLRRQKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F6</accession>
    <name>E8N4F6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_12860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63320">
        <property type="protein sequence ID" value="BAJ63320"/>
        <property type="gene ID" value="ANT_12860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12860"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="LVPEHRE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="237" mass="26126" checksum="650CA337EA0C674D" modified="2011-04-05" version="1">MMLEVKDLNVYYGAIHALKGVNFHVDKGEIVTLIGANGAGKSTTLNTISGLLRARQGSIVFQGEDITRTMPQDIVRKGIVQVPEGRKIFATLSVMENLEMGAYLNKDKAQIQRDLEMVLDRFPRLRERRNQYGGTLSGGEQQMLAIARALMSRPTLLLLDEPSMGLSPILVEQIFEIIQDINQQGTSILLVEQNAQMALSIADRGYVLETGRVVLEGPAQELLHNPMVIEAYLGGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I3</accession>
    <name>E8N4I3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559734.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63347">
        <property type="protein sequence ID" value="BAJ63347"/>
        <property type="gene ID" value="ANT_13150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13150"/>
    <dbReference type="HOGENOM" id="CLU_1486134_0_0_0"/>
    <dbReference type="OrthoDB" id="1494577at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="181" mass="21202" checksum="2C28E0D819237227" modified="2011-04-05" version="1">MKPHQPFETWIFDEHLSPEEQQRLTEHLRQCESCRALQQKWFEARGALQEKSMAAPRAGFVQRWKSSLVERKEREQRKQAWRVFWIFSGVASGVLVGVLVFFLTRFSMAEWLKLSVEVIHQFLGLTSSLGGILSAWMQLTPIPLHLFVSLLFLLSLLGLIVLWFVVLSRTFRKGEERSYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J1</accession>
    <name>E8N4J1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsT</name>
        <name evidence="9" type="ordered locus">ANT_13230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559742.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13230"/>
    <dbReference type="EnsemblBacteria" id="BAJ63355">
        <property type="protein sequence ID" value="BAJ63355"/>
        <property type="gene ID" value="ANT_13230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13230"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_0_1_0"/>
    <dbReference type="OMA" id="GVIHKNA"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="88" mass="9815" checksum="203AE7521DA07E44" modified="2011-04-05" version="1">MANIKSQIKRNKQNEKRRIRNRIVRGKARTAVAKAREALASQSVEEAKQAVLLAISSLDRAASKGVIHKNNAARRKSRLMKRLAALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R6</accession>
    <name>E8N4R6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_14020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559812.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14020"/>
    <dbReference type="EnsemblBacteria" id="BAJ63430">
        <property type="protein sequence ID" value="BAJ63430"/>
        <property type="gene ID" value="ANT_14020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14020"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028798_0_0_0"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="7">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="251"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="272"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="688" mass="80121" checksum="27CB39DCFAB790BC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X5</accession>
    <name>E8N4X5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nusB</name>
        <name evidence="8" type="ordered locus">ANT_14610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559871.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14610"/>
    <dbReference type="EnsemblBacteria" id="BAJ63489">
        <property type="protein sequence ID" value="BAJ63489"/>
        <property type="gene ID" value="ANT_14610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14610"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_3_3_0"/>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="155" mass="17386" checksum="7C8F5B5D1AD2A3D6" modified="2011-04-05" version="1">MKLRTRARAVALEALYEIDLTNHLPGDVLEERIKDAKLQDELADFAREIVMGVLPITHQLDVQIAKHAPEWPLDQVAVIDRNILRIALWEFAVGQCTPVKVAINEAVELAKKYGSDSSARFVNGVLGSLADRETEIKQEFSQFQSPLDPHQTSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z4</accession>
    <name>E8N4Z4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559890.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14800"/>
    <dbReference type="EnsemblBacteria" id="BAJ63508">
        <property type="protein sequence ID" value="BAJ63508"/>
        <property type="gene ID" value="ANT_14800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14800"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_0_1_0"/>
    <dbReference type="OMA" id="MVEINFD"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="31585" checksum="96E4A9BF41989AA1" modified="2011-04-05" version="1">MLWKRYLFPNSLQEAVQALRDARGRALPVAGGTDLLLQIQQGHHPPVDTLLDVTRIPELTRLERQGEMLFIGAAVPVGRIAVSDLVRRHATALAEACGQIGGPQVRNVATLGGNVAHALPAADGMIALVALGAQAWIASPEGMRQAPILSLFRGPGVSALDLTCEILVGFSLPVVEQGAGSAFARVMRPQGVALPILNMAIWLRRESQQIAEARLTAGPAGPTPRRAEKIEAFLRGKSPQDEGVLETCKGLLRECFAFRTSPARATAEYRYHLSEVLLEKVLFTAWKRAEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z7</accession>
    <name>E8N4Z7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14830"/>
    <dbReference type="EnsemblBacteria" id="BAJ63511">
        <property type="protein sequence ID" value="BAJ63511"/>
        <property type="gene ID" value="ANT_14830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14830"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_4_3_0"/>
    <dbReference type="OMA" id="PQFGTKH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="193" mass="21028" checksum="9179D405E0B4EC1B" modified="2011-04-05" version="1">MSGEEKPLQECPRCRIAVAELRQTFFQKTIPSFSNTSFPVIEVLLDNLRSTWNVGAIFRSADGAGVSRIHLCGITPTPENPQVVKTALGAEKSVDWEYHANGLTLALRAKSDGYHLIALEGGENSLPLHTILPLNDSRPILLVAGNEVTGIDPDIFELCDTVTFLPMFGIKNSLNVAVATGIALYLLRLSQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N510</accession>
    <name>E8N510_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_cc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559906.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63524">
        <property type="protein sequence ID" value="BAJ63524"/>
        <property type="gene ID" value="ANT_14960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14960"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884667_0_0_0"/>
    <dbReference type="OMA" id="ILAFRTW"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Unchr_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_cc" evidence="1">
        <location>
            <begin position="27"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="35798" checksum="589C94969B0773DA" modified="2011-04-05" version="1">MGILVFTAPEDDSFWRVGFGVSESLSSKQWANNLGAGWYLDWRALPRHALRSPQYWMMIRTFPDRNIPDLNSAAEIARTHPGNVWIIGNEPDNPYQDSLSPEEYAWRYEQFYSALKQADPTCLVAIAGVTQPSELRMRYLERVLSAYQKRAGVPMPVDIWTVHGYVLREERGNWGAEIPPGMDEITQGLLIEPEKHGEIALFKSQILAFRTWMKLQGYQDTPLVITEMGILLPEEFGYTPDAVADYLSETFSWLNTAIDPEIGYRADEGRLVQRWAWFSLADRTFPVSNLLDPSSGELTPAGKAFQTFTRSHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N547</accession>
    <name>E8N547_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_15330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559943.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63561">
        <property type="protein sequence ID" value="BAJ63561"/>
        <property type="gene ID" value="ANT_15330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15330"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_1_0"/>
    <dbReference type="OMA" id="WVKIRTY"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="233" mass="26346" checksum="BE730B4E6E48434F" modified="2011-04-05" version="1">MDKNLLLKNNPLLLDISEEDLLVLIANSLQIKAEAGSYLFFQGDPADSLYFLTEGHVRLISFTPEGQQVLMHVVTPGNFFAIIALVPGSTYPVSAEVTLDSTLLKWNKNSLQKVLKTVPVFALQAMRLMSERLQEYQQRFKEIATQRVERRLARMLIRLASQSGVKSDEGIVINLPLTRQDLAEMIGTTLYTVSRFLSHWENQGIILSRREKVIIVNSHLLMCIAEDLPYSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N548</accession>
    <name>E8N548_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1858 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63562">
        <property type="protein sequence ID" value="BAJ63562"/>
        <property type="gene ID" value="ANT_15340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15340"/>
    <dbReference type="HOGENOM" id="CLU_2448207_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="89" mass="10308" checksum="D6D02C1F0A61F531" modified="2011-04-05" version="1">MIIHKARVFLSRYNQNVNTIITLDTTIYELLKQYPHVASLFVQKHMVCVGCPMGIFDTIREAALYHYVDPQKFFDQVMLLIQSSGNISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A1</accession>
    <name>E8N5A1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559995.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63615">
        <property type="protein sequence ID" value="BAJ63615"/>
        <property type="gene ID" value="ANT_15890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15890"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_1_0"/>
    <dbReference type="OMA" id="PCREREP"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="388" mass="43599" checksum="20C4049449FB7F71" modified="2011-04-05" version="1">MRILISLTYYRPHYSGLTIYTERLAKALVSRGHEVTVLTSRFHADLPTEEYRDGVRIVRSSVAFRLSKGVIMPSMPFKGWNLIRQADVINVHVPQMDAAYLAVMARILGKKVVMTYHCDLLLPRGFIHRMANWGSTLANEVSARASHLIVTNTQDYALHSAFLKRHLSKVRPVLPPIEMPVVQNGEIEQFRDKYRIKPEEKIIGISARMATEKGVEYLVQAMPMILERFPHARVLYNGQYENVLGEEEYFKRLMPQIQALGDRWTFLGIIPPVEQAAFFSVCDVTVLPSINSTESYGMVQVESMFCGTPVVASDLPGVRHAVQTSGMGTVVPPRNAKALAEAIIQILETPANYCGNIPEIKTRYASDTIASQYEAIFRELLEQGGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G2</accession>
    <name>E8N5G2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560055.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63676">
        <property type="protein sequence ID" value="BAJ63676"/>
        <property type="gene ID" value="ANT_16500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16500"/>
    <dbReference type="eggNOG" id="ENOG5033NHV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180396_2_0_0"/>
    <dbReference type="OrthoDB" id="2096002at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021375">
        <property type="entry name" value="DUF2997"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11211">
        <property type="entry name" value="DUF2997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="69" mass="7507" checksum="94E6AF62D8191E39" modified="2011-04-05" version="1">MEIQEIEVVILPDGKVEVRVRGVKGQACLELTAEMEKALGGTILLREMTPEAQEPPTAIDQSDTLSLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I0</accession>
    <name>E8N5I0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP pyrophosphokinase</fullName>
            <ecNumber evidence="5">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">relA</name>
        <name evidence="5" type="ordered locus">ANT_16680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560073.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63694">
        <property type="protein sequence ID" value="BAJ63694"/>
        <property type="gene ID" value="ANT_16680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16680"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_0"/>
    <dbReference type="OMA" id="DWISSPK"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="44"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="408"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="659"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="733" mass="83518" checksum="526DF7035F405B0C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J8</accession>
    <name>E8N5J8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63712">
        <property type="protein sequence ID" value="BAJ63712"/>
        <property type="gene ID" value="ANT_16860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16860"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252859_0_0_0"/>
    <dbReference type="OMA" id="DRNDTPW"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1424" mass="160788" checksum="3D5B44A6D3CD7F18" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L2</accession>
    <name>E8N5L2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosidase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560105.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63726">
        <property type="protein sequence ID" value="BAJ63726"/>
        <property type="gene ID" value="ANT_17000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17000"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_6_3_0"/>
    <dbReference type="OMA" id="TPDWVKH"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="18"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="485" mass="56227" checksum="8577DA0911707C24" modified="2011-04-05" version="1">MSANFQTPKWVHDAVFYQIFPDRFAKSALVEKPTHLEDWDAPPTPYGFKGGDLLGVTEHLDYLQDLGITAIYFTPIFQSASNHRYHTHDYFKVDPLLGGEKAFQTLLKEAHRRNIRIVLDGVFNHASRGFFQFNHILECGKQSPYLDWFKIHGFPLNAYEGKPRYECWWSIPALPTFNHANPQVRKFIMEVGRYWLEQGIDGWRLDVPFEVKEPGFWEEFRSVVKSVNPEAYITGEIPWDARPWLQGNQFDGVMNYLLTYSLWSFFGGEHLQEDLVGHWRSHGPEYFVKDAESFAQQITLLQNLYPLPAVQAQMNLLDSHDTARFLSLVNGRKEALRLAALVLFTYPGAPTIYYGDEIGMEGGKDPDCRRGFPWDTSRWDMDLRNYFKSLIMIRKSHPALRDGSWEILKAENQWLAYARKHENDYVVVLLNNSPQTNFLEVTLKEFSGEESLKNLLNGEMVKIEGNILRYKLAPYSGTILSQGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U9</accession>
    <name>E8N5U9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase formation protein HypC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hypC</name>
        <name evidence="2" type="ordered locus">ANT_17870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560191.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63813">
        <property type="protein sequence ID" value="BAJ63813"/>
        <property type="gene ID" value="ANT_17870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17870"/>
    <dbReference type="eggNOG" id="COG0298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159381_1_0_0"/>
    <dbReference type="OMA" id="MCLAIPC"/>
    <dbReference type="OrthoDB" id="2031925at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="81" mass="8789" checksum="4DF9F6637939D7D4" modified="2011-04-05" version="1">MCLGIPGKIVEIYQQGGLRMGKIDFGGVIREACLESVPEAEIGQYALVHAGFVINLLSEEEAQETLRLLSEISALDEEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W3</accession>
    <name>E8N5W3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63827">
        <property type="protein sequence ID" value="BAJ63827"/>
        <property type="gene ID" value="ANT_18010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18010"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105945_1_4_0"/>
    <dbReference type="OMA" id="DSTCELQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039543">
        <property type="entry name" value="POX18/UbiT/NSL-TP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="PTHR10094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="125" mass="14234" checksum="90EAAE47676B4917" modified="2011-04-05" version="1">MQVQSEKFWRVEEIMQEPEKNQITQILLQAFQPEKAGGIKAVIQVELSGMNGGNYYLRIENGHLEGGEGRVEKPHLTLVSDMQTLMDILQKKSDPMNAFFQGRLQVKGDMGLAMKLIQVFKNPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z6</accession>
    <name>E8N5Z6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZnF_CDGSH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560237.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63860">
        <property type="protein sequence ID" value="BAJ63860"/>
        <property type="gene ID" value="ANT_18340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18340"/>
    <dbReference type="eggNOG" id="COG3369">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2731160_0_0_0"/>
    <dbReference type="OrthoDB" id="2002590at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="71" mass="7886" checksum="0FBFA1E084C9D9DB" modified="2011-04-05" version="1">MPEFSTVEKNGHFRHIIQLKPGERVSLCRCYGSKNFPFCDGTHNQIHSNVGPAIIEVPASVEENEEGTQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z8</accession>
    <name>E8N5Z8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18360"/>
    <dbReference type="EnsemblBacteria" id="BAJ63862">
        <property type="protein sequence ID" value="BAJ63862"/>
        <property type="gene ID" value="ANT_18360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18360"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_2_0"/>
    <dbReference type="OMA" id="RDRFMFS"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="35287" checksum="8E3D0DCB1DBD6E0E" modified="2011-04-05" version="1">MSITDVQQLSEKILQNLERVIIGKRQVLELTLIGLLSQGHILIEDVPGVGKTMLARSLAKSLGCSFNRLQFTPDMLPSDITGVSIFNQVSRNFEYRPGPIMAQIVLADEINRATPKTQSALLEAMEERQVTVDGVTHPLPTPFLVMATQNPIEYEGTFPLPEAQLDRFLLRIRLGYPSLEDEIKILGEQQYQHPIQTLEPVLSQEELLQMQETVKSVFVSPAVKRYIVELSRATRENDDVYLGASPRGSLGLARASQVRAAMQGRDYVLPDDVKALAESILAHRIVINPAARLKNLTSSQIVNEIVSALPVPGGLMSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N625</accession>
    <name>E8N625_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_18630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18630"/>
    <dbReference type="EnsemblBacteria" id="BAJ63889">
        <property type="protein sequence ID" value="BAJ63889"/>
        <property type="gene ID" value="ANT_18630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18630"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_3_0"/>
    <dbReference type="OMA" id="EIDCGIN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="231" mass="26151" checksum="7D2BA2489E2323D5" modified="2011-04-05" version="1">MGPGSVFYNKSMILFQDEWILVISKPAGLLSIRDGYNPNLPTIQGVLEPKLGKLWMIHRLDKDTSGIMVLARTSEAHKNLDRQFAERKVRKIYYAICVGVPEWDEILIQSPLRVNGDRKHRTVVDFEHGKPAETHVRVISRYGFYTWVEVHPHSGYTHQIRAHLSSIGYPLLGDSLYRIPPNCAVIPPKAENLPAFPRVALHAYALTFSHPNSGEEITFTAPLPEDFSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N648</accession>
    <name>E8N648_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4332 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560289.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63912">
        <property type="protein sequence ID" value="BAJ63912"/>
        <property type="gene ID" value="ANT_18860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18860"/>
    <dbReference type="eggNOG" id="COG3743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117602_1_0_0"/>
    <dbReference type="OMA" id="GTQYCGL"/>
    <dbReference type="OrthoDB" id="1642788at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025567">
        <property type="entry name" value="DUF4332"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14229">
        <property type="entry name" value="DUF4332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4332" evidence="3">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="14822" checksum="108611867D99D057" modified="2011-04-05" version="1">MTALVDIEGIGEVYAEKLKAAGISSVEKLLEAGSTPKGREDLAKQTGISKDLILKWVNRADLYRVKGIGSEYSDLLEAAGVDTVVELAQRNPEALYKKLEEVNAEKKLVRRMPTPAQVTEWVESARQLPRAVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N684</accession>
    <name>E8N684_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63948">
        <property type="protein sequence ID" value="BAJ63948"/>
        <property type="gene ID" value="ANT_19220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19220"/>
    <dbReference type="HOGENOM" id="CLU_2353740_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="96" mass="10778" checksum="A89BF02933CD871D" modified="2011-04-05" version="1">MIETPQTQPTFVNRYATEMAELALSRILPNATEEFPSRTPWITSSPKANAVTSEPAREKAFNLSRFGLGVSISLILVLGFFLVFRLLQSGEFRSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B5</accession>
    <name>E8N6B5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19530"/>
    <dbReference type="EnsemblBacteria" id="BAJ63979">
        <property type="protein sequence ID" value="BAJ63979"/>
        <property type="gene ID" value="ANT_19530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19530"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_612000_0_0_0"/>
    <dbReference type="OMA" id="FRYLEMA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="447" mass="50330" checksum="4ECE5C4598A4D70C" modified="2011-04-05" version="1">MVEVFVFTHLRTQCNRRWSCDCDHHHSPEKDSIQSEIKLYLNGGHTMKKPTLFSTLVICIFLVLSGTVQAVPAQAQTSTTLYLPLIRRAATTSCRFGIAAIPENAGYAVSLAQFKVGGFVDWNNNPGRVLPGDVTYLRVISVSDPFDDVQVANYAANLARAYPGSYWQIGNEPDTTYQGHGIYQDNVTASQYGHRYYVIATAIRQADPTAKLGFGSVVQPTAVRFRYLEMALARLIQDSGNASTAYGLIDFLSIHAFILNEDEDHNDDGIIDNKWGTGVPKDYNDPYLYCITTNPDGTCKTKILPEALTPAQTYDINRFKSRIQNMRQWMYNNNLRNKPLWITEYGSLLPPITRPEDNLTTLPDSVTAQYMVNTFDYLRTATSTTTGLPADGNRLVQRWFWYSLNEHRYWFGGSLYDPDTSPPQLTLIGQTFINYMAPLMPEEGCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI9</accession>
    <name>E8MXI9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20440"/>
    <dbReference type="EnsemblBacteria" id="BAJ64070">
        <property type="protein sequence ID" value="BAJ64070"/>
        <property type="gene ID" value="ANT_20440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20440"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335239_0_0_0"/>
    <dbReference type="OrthoDB" id="2213949at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="205" mass="22789" checksum="2DA5C8CAF0018729" modified="2011-04-05" version="1">MFKMLFWLLRWFGVFLIGWLVPSSQQVMVDTPKPGEAVQGQVIIAGNVDLEGFQSYEVSFAYQKDETNTWFLIGRGEQIVRGGTLATWDTTTITDGQYRIRVRVYLAEGKIAETVVQQVRVRNYTPIETSTPVPQGAVGTQKTPITIADYTPSRMEVQSTSSANPLEISSDKLQRSFLLGGVVAIGLFILLGGYFLLQVLFRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK1</accession>
    <name>E8MXK1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">acpP</name>
        <name evidence="5" type="ordered locus">ANT_20560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560452.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64082">
        <property type="protein sequence ID" value="BAJ64082"/>
        <property type="gene ID" value="ANT_20560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20560"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_3_0"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="78" mass="8931" checksum="E9FA7E6F3A23CF4E" modified="2011-04-05" version="1">MSDTFEQVKAVIMDVMKIDGEGITMETRFVEDLKADSMDQFFLIDGFCEKFNMSISDEDARQIRTVGDAVRYIDAHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN7</accession>
    <name>E8MXN7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein ANT_20920</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560488.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20920"/>
    <dbReference type="EnsemblBacteria" id="BAJ64118">
        <property type="protein sequence ID" value="BAJ64118"/>
        <property type="gene ID" value="ANT_20920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20920"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_2_1_0"/>
    <dbReference type="OMA" id="PPCRFDA"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="121" mass="14054" checksum="72C4304343BBC28C" modified="2011-04-05" version="1">MSLYRQRVGKWGEDLAARYLSQKGYLILARNVRTEYGEIDIVAQRDQTMVFVEVKTRTNRDFGYPETALTEKKKSHLFKAIQAYLQKENSEPTAWQVDVLAILREKGGETLIEHFENALTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR0</accession>
    <name>E8MXR0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_21150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560511.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64141">
        <property type="protein sequence ID" value="BAJ64141"/>
        <property type="gene ID" value="ANT_21150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21150"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_2_0_0"/>
    <dbReference type="OMA" id="WAPLVPY"/>
    <dbReference type="OrthoDB" id="1121832at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="429" mass="45732" checksum="43FAED7C3E7EA159" modified="2011-04-05" version="1">MKITFQKGKTVNLLKKIKSYPRLGVVLLAFVAFVALGLPDGLLGVGWPSIRNSFSIPLDAIGMLLTASVAGYMASSFMSGVMLSRLGVGKVLALSCFLTGLALIGYTLVPQWWMMVLLGIVAGLGAGAIDAGLNTYVAAHFGEGLMQWLHASWGVGITIGPIIMTLGLSSLETWRFGYWVVGGFQIALAIGFTLTLPMWNQGHVRFPAHENAQPEKKLTDYQTPLSETLRKPCVWLSVLLFFLYVGAESSLGTWTYTLLTESRGVDKTLAGFFAGSYWFTFTIGRILAGLVAHRVGINKLVLGGLTGALLGAGLLIWNPAEIANVIAVGLIGISIAPIFPAMMSGTRIRVGDKYAANTIGLQMAATGFGTAVIPSTMGVLARHISLEVIPVYLLAVYVSLLGVYLLAIRPERAPSKGKVQPLAQIDSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY41</accession>
    <name>E8MY41_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rnc</name>
        <name evidence="10" type="ordered locus">ANT_22460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64272">
        <property type="protein sequence ID" value="BAJ64272"/>
        <property type="gene ID" value="ANT_22460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22460"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_0"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="165"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="237" mass="26252" checksum="0B3C6F628EBC917B" modified="2011-04-05" version="1">MNENALAESPQEFANRLGLSFKSFFLLSRALTHRSYLNEHPEAIEDNERLEFLGDAVLDFVVGAWLYNRYPDMPEGDLTRMRSVLVSTEQLSEFARKVDLGRALRLGKGETQAGGRDRPALLCDAFEAVIGAIYLDSGIEGVRRFIEPMLEKAADEILARQTIEDPKSMLQEWAQGQGFQAPRYIVRSSSGPEHSKQFEVDVLINGQIYGSGIGSSKQAATKAAAADALKRLGLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY73</accession>
    <name>E8MY73_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_22780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560671.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22780"/>
    <dbReference type="EnsemblBacteria" id="BAJ64304">
        <property type="protein sequence ID" value="BAJ64304"/>
        <property type="gene ID" value="ANT_22780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22780"/>
    <dbReference type="eggNOG" id="COG1047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098197_1_0_0"/>
    <dbReference type="OMA" id="HSHEGGC"/>
    <dbReference type="OrthoDB" id="2044224at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="188" mass="21000" checksum="3B8EECC71E5185B6" modified="2011-04-05" version="1">MANTEKPTVVADDVVVTLDYTLTVNGEVLDTTEGSEPIQFLQGHQNIIPGLERELYGMKIGDTRNVLVKAAEGYGEYDPEAVIDVPRSEFPPDIPLRVGVDLTVRNESGELLDARIASVGKDMVQLDFNHPLAGKDLNFEVTVVDLRNAEPEELAHGHVHDEFEEEELEFDFDEDFEDEDEEETGKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY75</accession>
    <name>E8MY75_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit 2</fullName>
            <ecNumber evidence="8">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cydB</name>
        <name evidence="8" type="ordered locus">ANT_22800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560673.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22800"/>
    <dbReference type="EnsemblBacteria" id="BAJ64306">
        <property type="protein sequence ID" value="BAJ64306"/>
        <property type="gene ID" value="ANT_22800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22800"/>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049294_0_1_0"/>
    <dbReference type="OMA" id="WVWMLIL"/>
    <dbReference type="OrthoDB" id="761975at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="337" mass="37904" checksum="5F37EE5E4C5780E9" modified="2011-04-05" version="1">MDLNTVWFILIAVLYLGFFVLEGFDFGVGILLPFLGKTDQERRVIINTIGPHWDGNEVWLITAGGATFAAFPHWYATLFSGFYLPLFLILLALILRGVAFEFRSKDENPKWRTFWDWAIFGGSLVPALLFGVAFTNIMAGVPIDANMTYVGGFWNLLNPYALIGGLTSLLGFILHGAVFLSLKTDGEMMTRAQDAARKVWLPATLVLVVFIIATYFFTDVLQQLGINPGPIPIGAFFTMLAAGYFVYTRRSGWAFFMTTLTILFATATIFMILYPRVMVSSLDPAYSLTIYNAASSPYTLRVMSIIALIFVPIVLAYQAWSYWVFRKRITAKQELHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY76</accession>
    <name>E8MY76_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gpmA</name>
        <name evidence="6" type="ordered locus">ANT_22810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560674.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22810"/>
    <dbReference type="EnsemblBacteria" id="BAJ64307">
        <property type="protein sequence ID" value="BAJ64307"/>
        <property type="gene ID" value="ANT_22810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22810"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_0"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="248" mass="28459" checksum="5FDD28462A06EA38" modified="2011-04-05" version="1">MIKLVLLRHGQSTWNLENRFTGWTDVDLSEQGIQEAHEAGRLLREAGYTFDIAFTSVLKRAIRTLWIALDELDQMYIPIENAWQLNERHYGALQGLNKAEMAEKYGKEQVHLWRRSYNVPPPPLDWDDPRHPRFDPRYAKVDPALLPACESLELTLKRVMPYWESEIVPRLKAGEKVLIAAHGNSLRALVKHLDNMSDEDIVELNIPTGIPLVYELDDNLKPITHYYLGDPEKAKAAAEAVAKQAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB4</accession>
    <name>E8MYB4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosyl-[dinitrogen reductase] glycohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">draG</name>
        <name evidence="1" type="ordered locus">ANT_00250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.24" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62059">
        <property type="protein sequence ID" value="BAJ62059"/>
        <property type="gene ID" value="ANT_00250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00250"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_8_2_0"/>
    <dbReference type="OMA" id="PGTWTDD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047407">
        <property type="term" value="F:ADP-ribosyl-[dinitrogen reductase] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="308" mass="33361" checksum="D7724097217D8210" modified="2011-04-05" version="1">MKMTLQNRFRGCLLGLAVGDALGTTVEFRPRGSFEPLTDMLGGGPFHLKPGQWTDDTSMALCLASSLVACRGFDPRDQMERYCRWQDEGYWSSTGDCFDIGGTVAAALARFRATGEPFAGSTDPYSAGNGCIMRLAPIPMFYYPDLDAAEHYAAESSRTTHGAAECVDASRLMARMLVRALAGKSREEVVLGDRETFTGSPRITAIARGEYLEKDEAQIRSSGYVVHTLEAALWCFWRSESFADAVLRAANLGEDADTTAAVCGQFAGAFYGETGIPAGWLEKLALQEDIRALADALAEGKEEQRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ9</accession>
    <name>E8MYJ9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_23090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560702.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23090"/>
    <dbReference type="EnsemblBacteria" id="BAJ64335">
        <property type="protein sequence ID" value="BAJ64335"/>
        <property type="gene ID" value="ANT_23090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23090"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131756_0_0_0"/>
    <dbReference type="OMA" id="RISWIDI"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="26441" checksum="4B44AE0FBFF456D7" modified="2011-04-05" version="1">MIRKDSPQSVIESYRRRQQMGPFIVWGLAVLLVVVGIIILVVWFTGQNRPAISLFASPTPTATSTFTPTPVTPTSTPTVTPTETLTPTVTETPTPQGPFEYTVQEGDTCWDIAVKFEADLLVLLTLNNFGNTCPIKPGDKILVPVKGQELPTETPLPTDLPRGQKIEYIVKTGETLDIIARRFNSTIEAILKENKLTDANKISAGQKLIIPVNIVTPTPTRAPTRTTTPGGSTATPVPPTATATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK6</accession>
    <name>E8MYK6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nuclease SbcCD subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sbcC</name>
        <name evidence="8" type="ordered locus">ANT_23160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560709.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23160"/>
    <dbReference type="EnsemblBacteria" id="BAJ64342">
        <property type="protein sequence ID" value="BAJ64342"/>
        <property type="gene ID" value="ANT_23160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23160"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_0_2_0"/>
    <dbReference type="OMA" id="ISHVQEM"/>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="7">
        <location>
            <begin position="379"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="179"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="448"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="852" mass="98744" checksum="940F2A6E20091117" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYM2</accession>
    <name>E8MYM2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23320"/>
    <dbReference type="EnsemblBacteria" id="BAJ64358">
        <property type="protein sequence ID" value="BAJ64358"/>
        <property type="gene ID" value="ANT_23320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23320"/>
    <dbReference type="HOGENOM" id="CLU_1552107_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="172" mass="19285" checksum="8150360923B77DC5" modified="2011-04-05" version="1">MPMKREKQSGGIQGMVQKTLQQAYQQAPWRKATRKGMLFLILAFLSVLLVWISLTISVESAEAAIEISRLEKQKEFLEYKIASLNTEIALQSSASVMEERAKLLGYRPATPEEIVYMTVPGYPGKQTTLVLPPPPSSQEETIILKSSYQQSLSDWLFQGLAQIENLQRGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN5</accession>
    <name>E8MYN5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsA</name>
        <name evidence="8" type="ordered locus">ANT_23450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23450"/>
    <dbReference type="EnsemblBacteria" id="BAJ64371">
        <property type="protein sequence ID" value="BAJ64371"/>
        <property type="gene ID" value="ANT_23450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23450"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_3_2_0"/>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="414" mass="44285" checksum="EAC2B2CDE4FA64B9" modified="2011-04-05" version="1">MKMADEPIVVGIDIGTTKVCTLVARVEGGSSFRILGVGIEPSQGIRKGTIVDLQAASQAIARSIEKAERTSGMEITSALVSLAGSHVSSVNSRGVVGIAGRVIDQEDVFRALDAAQAVAIPHNREIIHVIQRGFVVDGQDGIRMPVGMHGYRLEVEAHIITAAASTVENLRQCVQASGVEVVQFVLNPLASAEVVLSDTERQMGVVVCDIGGGTTDMAIYIDGDIWHTMVLGIGGNHITSDIAHGLRLPLSQAEEIKKLYGHAVQSDIPENETFSTRIFGEERPVEISRRDLAMIIEARVEEIFDLILQEIKRSGYDGLLPAGVVLTGGSSLLPGIRTLASQVMGLPVRIAKPENLLGLTDQLNSPAYSTSVGLLSWAMMMSETPAAAGKRSRKKGGSSEFGDWFKSFLKRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ6</accession>
    <name>E8MYQ6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560758.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64392">
        <property type="protein sequence ID" value="BAJ64392"/>
        <property type="gene ID" value="ANT_23660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23660"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068892_0_0_0"/>
    <dbReference type="OMA" id="RPYWVSP"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="322" mass="36270" checksum="F81370D966D47E17" modified="2011-04-05" version="1">MENLQIPINLFFQSLGMWLAPIMQFFSFLGTEEFFLMVMPAVYWCIEPRLGIRLGWMLVLTNWVNGIAKLAFHAPRPYWVSAEVKALSSETSFGMPSGHAQNAAALWGLASTQVQWRWFRWLSLAIILLIGISRIYLGMHFAGDVLVGWAIGAVLVWLFVRLEPGILEWAKRQSIRNLGMVIFLASLLIIAGFSLSNVLFGDWNIPTAWVSLAAKQTPNTPIDPRNIEGGFTLGGILFGFGLGAVWLDRRYGLPTGGSREQRILRYLLGIAGVMILWYGLGKLFPDNANAISYMLRYLRYALIGSWVSVFAPLLFRRLHLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYR1</accession>
    <name>E8MYR1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="8 10">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">hisA</name>
        <name evidence="11" type="ordered locus">ANT_23710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8 9">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="8 10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560763.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64397">
        <property type="protein sequence ID" value="BAJ64397"/>
        <property type="gene ID" value="ANT_23710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23710"/>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_0"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="OrthoDB" id="794219at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="248" mass="27066" checksum="3C2EBD9FF5A5A18C" modified="2011-04-05" version="1">MNTFTVFPAIDLRAGQVVRLQEGDPSRQTVFSHDPAEVAYRFLSQGARWLHVVNLDGAFGEEKSAGLNLRAIEQMLEITPEFSASLQVGGGVRSLKAVADLLVRGVRRLVVGTMAIEHPELLKQAVQKWGEERIAVSLDVRNGMVYVRGWQESGGILLEDAARFIQSCGVRWVVFTDISRDGMQTGLALDEASALAEKFGFQVIASGGARSLAEVRQAREQGLAGVILGRALYEGKILLEEALREEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ05</accession>
    <name>E8MZ05_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_01140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558546.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01140"/>
    <dbReference type="EnsemblBacteria" id="BAJ62148">
        <property type="protein sequence ID" value="BAJ62148"/>
        <property type="gene ID" value="ANT_01140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01140"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="MRDEIMD"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="236" mass="26156" checksum="B76902275694F3B8" modified="2011-04-05" version="1">MNTSPILTLKQVRKTYLSGDQPLEVLKGIDLEVYAGEFVLIYGKSGSGKTTLINMIAGIDPLTAGEVWFDGVNVHRLNENQRARWRGRNVGIVYQSFYLMPTLSLLHNVMLPMDVCGLYHPRRSPQRALELLRMVELEEHAHKLPSAISGGQQQRVAIARALANDPPLIIADEPTGRLDSITAATILEIFLNLARQGKTILMVTHDLSLMPLASRCFRLEGGLVHSCPVEERTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ07</accession>
    <name>E8MZ07_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558548.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01160"/>
    <dbReference type="EnsemblBacteria" id="BAJ62150">
        <property type="protein sequence ID" value="BAJ62150"/>
        <property type="gene ID" value="ANT_01160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01160"/>
    <dbReference type="HOGENOM" id="CLU_1243209_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003227981" evidence="1">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="23475" checksum="B2F2A45742DCD7DF" modified="2011-04-05" version="1">MKPFFSLSVLLLSAVLMLTACAGSGEIRAIPLTPLPSATPLPTSTPLPTATPVPMPTEAATLPAERVESCLVGRWIVSDASPYFQTAFQGTDIVLGGTSGNAWYNFGEAGIFLLEAIQFAQSAAVKTDVGEVPVDVVMDGIALARYRVEGDKVFFREQSVTSLVFQVEAFGETLGLDPAGLLGDAAAGETAFLFECVGADRLLLTPPLDNYGVFPLVLERYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ08</accession>
    <name>E8MZ08_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_01170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62151">
        <property type="protein sequence ID" value="BAJ62151"/>
        <property type="gene ID" value="ANT_01170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01170"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_4_0"/>
    <dbReference type="OMA" id="TISNTFR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="175"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="35443" checksum="F50A450F121822E3" modified="2011-04-05" version="1">MQMQVNERVKGPYKQWLDHLFDGVYVVDMHRRIQYWNAAAEELTGYTAGEVCGTRCSDNILEHVDFAGKALCKEGCPLHATLQDGQRREALVFLHHKNGHRVPVHIRVSPLYDDEGKVTGAIEVFSDHSQHLTIAKELEHYKQESLLDPLLRIGNRRYAQMVFQVRQYEYGVTQTPFGALMLDLDLFKHVNDTYGHHVGDLVLKMVTQTIVRVLRGSDALFRWGGDEFLAFLPAITSGGLLVASERIRSMVEASFVMVEGQRIQTTLSVGATLAVPEDTLESLVERADLLLYQSKQKGGNHCTVEERFPHNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ12</accession>
    <name>E8MZ12_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558553.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62155">
        <property type="protein sequence ID" value="BAJ62155"/>
        <property type="gene ID" value="ANT_01210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01210"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_3_0"/>
    <dbReference type="OMA" id="TWLAHGI"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="57"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="463" mass="49868" checksum="AA997F38CCD5535F" modified="2011-04-05" version="1">MTTLLVKNISFLVTMDGARREIVNGAIFARDGIIEQVGQTADLPATADRVLDLNGYIVFPGLINTHHHFYQTLTRVVPAAQDANLFNWLKTLYPIWARLTPEDIYISTQTALAELALSGCTTASDHLYLYPNGSRLDDEIAAAREVGLRLHASRGSMSLGESKGGLPPDSVVDSEEHILRDSQRLIEQYHDPKPGSMVQIVLAPCSPFSVTGDLMRESAVLARQYGVHLHTHLAETQDEEVFCLQKFGMRPVEYMESLGWVGNDVWFAHAVHVNPAEIEVFAHTGCGVAHCPSSNMRLASGIAPVMPYIKAGVKVGLGVDGSASNDGSHMLEEVRQAMLLARLSAGLQGASLSGQDAPPLMTARQALELGTRGGAAVLGRNDIGALEAGKCCDFAAIRLDRLTYAGAQHDPVAALAFCAPQNVDILSVGGNLVVEDGQLRTVDVPRLVERHNRAAQRLVTGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ61</accession>
    <name>E8MZ61_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558602.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01700"/>
    <dbReference type="EnsemblBacteria" id="BAJ62204">
        <property type="protein sequence ID" value="BAJ62204"/>
        <property type="gene ID" value="ANT_01700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01700"/>
    <dbReference type="HOGENOM" id="CLU_1036838_0_0_0"/>
    <dbReference type="OrthoDB" id="1223377at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="268" mass="30760" checksum="A5C737A99CA13B89" modified="2011-04-05" version="1">MIQPAFFPTLPPEVEDMDIESLCSALESIRRPLVQAIFADLYRNPFWEDRYGETGIVHISRDLDQHLDYLLTAVRLRSPEYLTEYFRWVRHSIILRGMCTRHLEQVLDSLASHTGAMLPLETSQALSVFLDAARASLSYNHFACRSLSPTIDFIATQVAGHIYPDEAQAARRELCRRDILIHLSYLMDAVEKANPEIFFGYLEWLRAFDRKYGISTRELVLTFSEMHRQIVQRLGEETAQPFTHIFTHLPALNGQPAAAQSNGGYRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ68</accession>
    <name>E8MZ68_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558609.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01770"/>
    <dbReference type="EnsemblBacteria" id="BAJ62211">
        <property type="protein sequence ID" value="BAJ62211"/>
        <property type="gene ID" value="ANT_01770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01770"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_11_2_0"/>
    <dbReference type="OMA" id="WMAREGH"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="408" mass="44657" checksum="101EEB3490956574" modified="2011-04-05" version="1">MHILLIHQAFVSLGEAGGTRHHELARYLVQRGHRVTIICSPVSYLTGKVETRTSQEEEEGITIRRAYTYAALHRSFFHRVLAFVSFMLSSFWIGLSVRQVDLVWGTSPPIFQGVTAWALARLKGVPFLFEVRDLWPAFAIAMGVLRNPLLIGASQALERFLYRHADRVLVNSPGFIDHVTARGATWVELVPNGADPEMFDPAARGEAFRAAHGLDGHFVVLYAGAHGPSNDLGVVLDAAEHLQDEPRICFVLVGDGKEKPALMKQAQERGLKNVLFLPPAPKAQMGEIMAAADACLAILKPLELYKTTYPNKVFDAMAAGRAVVLAIDGVIRQVVEETGAGVFVPPGDAQALAQAVRMLADNPQAAREMGEAGRRCVERRFHRQVLAEQLALIMEQMGGENGRKNSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ92</accession>
    <name>E8MZ92_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoadipate CoA-transferase</fullName>
            <ecNumber evidence="1">2.8.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">catJ</name>
        <name evidence="1" type="ordered locus">ANT_02010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.3.6" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558633.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62235">
        <property type="protein sequence ID" value="BAJ62235"/>
        <property type="gene ID" value="ANT_02010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02010"/>
    <dbReference type="eggNOG" id="COG2057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069088_0_0_0"/>
    <dbReference type="OMA" id="YWVGNHS"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047569">
        <property type="term" value="F:3-oxoadipate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="27359" checksum="E0B1BDC9E73656AC" modified="2011-04-05" version="1">MDTAYTSSELMIINAARLLRDGDVVFVGVGIPNLACNLARRTHAPNLYMIYEAGVIGARPNRLPLSIGDPTLVSGAAAVCSMYDIFTLYLQRGNVDVGFLGGAQIDRFGNINATVIGDYAHPKVRLPGSGGSMEIAAWANRCYIMTPHQKRRFPERVDFHTSAGFLSGKGERQASGVRGKGPQAVVTNLGILEPDENGELILTALHAGATVEMARENTGWALKVAPSLRITEPPTAEELRILREELDPQGIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZB7</accession>
    <name>E8MZB7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YlxR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_02260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558658.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62260">
        <property type="protein sequence ID" value="BAJ62260"/>
        <property type="gene ID" value="ANT_02260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02260"/>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147970_2_1_0"/>
    <dbReference type="OMA" id="CVGCQEM"/>
    <dbReference type="OrthoDB" id="2067975at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="114" mass="12484" checksum="54D7E47511155312" modified="2011-04-05" version="1">MTKKTGQRVKHVPQRTCVGCRQVLAKRELVRVVRTAQGVRLDPTGKAAGRGAYVHALRSCWERALKGALAHALKTKLSDEDREQLMAYAAQLPQEEAGESSTALTGQQGNEMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD0</accession>
    <name>E8MZD0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR system Cms protein Csm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_24520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated Csm4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560833.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24520"/>
    <dbReference type="EnsemblBacteria" id="BAJ64478">
        <property type="protein sequence ID" value="BAJ64478"/>
        <property type="gene ID" value="ANT_24520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24520"/>
    <dbReference type="eggNOG" id="COG1567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062371_0_0_0"/>
    <dbReference type="OMA" id="YFSHFEF"/>
    <dbReference type="OrthoDB" id="2044338at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005510">
        <property type="entry name" value="Csm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040932">
        <property type="entry name" value="Csm4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17953">
        <property type="entry name" value="Csm4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01903">
        <property type="entry name" value="cas5_csm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Csm4_C" evidence="5">
        <location>
            <begin position="276"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="373" mass="41587" checksum="CBD3C22C9AB28B13" modified="2011-04-05" version="1">MPNLDVVALNFRGGVRVGKRGLELEETLATIPSDTLFSAMVSAWRLLGGNVDEFLKPFLADPPNPPFLITSTFPRAGEVRFYPAPVDLSLCISPDKLKDYGKKIKKVQYLSEGLFLRLLKGEKLDDWLFSKDDATTTAKGWRLQKGALWLSEEEIARLPKTFPLKPENRSGLMFQEVWKEARQPHVTVDRIGSQPEIYHTTQVHFHPDCGLWFGILWRDGEREIPSAGMSYRRALEKILQYLEHAGLGGKRAIGFGAFAHTLSPAAVELPLPAGGQAGLLISRYHPRPTELPQTLQHEKASYQLVSVGGWLKTPDSPNLMRKRLHMFSEGSVLAFPQFPAGDLSDVTPDIFTGGHRIYRYGMALAAGLEVQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD7</accession>
    <name>E8MZD7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ordered locus">ANT_24590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560840.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64485">
        <property type="protein sequence ID" value="BAJ64485"/>
        <property type="gene ID" value="ANT_24590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24590"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_3_0_0"/>
    <dbReference type="OMA" id="TYDIEND"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="96" mass="11122" checksum="BF90E127025054A8" modified="2011-04-05" version="1">MNDGRSFYVLAYDISDDRRRLKLARLMESLGVRVQGSVFEAYLTATELERLLRRCSKILKKEEDSLRIYRLCTACRENIRTEGKGKITPPPQVTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE1</accession>
    <name>E8MZE1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_24630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560844.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64489">
        <property type="protein sequence ID" value="BAJ64489"/>
        <property type="gene ID" value="ANT_24630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24630"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_659944_0_0_0"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="416" mass="46037" checksum="47C671D97439C884" modified="2011-04-05" version="1">MKRSPSIFLRRLALVSVGDLIAKGFTALTVILLIRSLTEADYAFYVSAEAVAFLLTEVISNGLNIALVRTLSFQHSRHGAIDLRLPVRLFLFEAAGITLIGVVAVTFPQPLAVLLLGKTEAVPAVQWGVFYALALVSFQLGRAMFQAVENFRGFTFLLLLRQGGIFFLILVNIWLGCLTAPLLIGILIGVNILSALFGWVKIQAMGGASATDSAWFWSFLRQAAWLIGYFVLLAVIARLDVLSVSRFASTLALAEYGTAARYYSMGLLFLGSVHAVLLPRFARAEMQVPDVQRRFIRQWFLATSWVILPIVLFDIWGKPLFVWLNGGKYAEAFSIWIIFSVGIWFSLMFSPLVNILIGQQRYRTLFFLSCISLVIALIGYNLVVPRWGGMGAAGVAVLSQFVINFGAFTGLVWSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF2</accession>
    <name>E8MZF2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_24740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560855.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64500">
        <property type="protein sequence ID" value="BAJ64500"/>
        <property type="gene ID" value="ANT_24740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24740"/>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_3_2_0"/>
    <dbReference type="OMA" id="MTRANCG"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04623">
        <property type="entry name" value="CBS_pair_bac_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044725">
        <property type="entry name" value="CBSX3_CBS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="148" mass="16292" checksum="7C130CCD86ED921E" modified="2011-04-05" version="1">MYSRVEDILKEKGNQIWSVSPDDTLLTTLLKLAEKNVGALLVMDGERIAGIVSERDIVREIALHRACVLDAPIKAFMTEDVITVNSQTTVDECMQLMTRAHIRHLPVVEGGKLVGIISIGDVVKKVIEGQASMIDDLEGYITGDKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM6</accession>
    <name>E8MZM6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25480"/>
    <dbReference type="EnsemblBacteria" id="BAJ64574">
        <property type="protein sequence ID" value="BAJ64574"/>
        <property type="gene ID" value="ANT_25480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25480"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_3_2_0"/>
    <dbReference type="OMA" id="LGDYPAG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="61"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="31868" checksum="CA31F54B82EAED86" modified="2011-04-05" version="1">MRRMSEKISRRKALQWLAGGLVSTLCVASGLDATLLEPYQVEIVPQPLALPQECCGWRGKRLAHISDLHFGGYYTLEQAQVVLNRMRDLNPDVVMMTGDYLTRGGNIAQALSDLHEFLPELAKTFPVYAVRGNHDYGPERQRLLDIFRQSGVHLLDNQWETFSLGGEELIIAGSGSLLAHWSGVRELAEAIPADKPAILLIHEPDGADYSAYLGRFFLQLSGHSHGGQVRLPLLGALFLPELGRRYPLGLYRVGEMWLYTNRGLGTTTLPVRFRCLPEITLFELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV2</accession>
    <name>E8MZV2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_02530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558684.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62287">
        <property type="protein sequence ID" value="BAJ62287"/>
        <property type="gene ID" value="ANT_02530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02530"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_8_0"/>
    <dbReference type="OMA" id="WQGINLE"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228511" evidence="1">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="77"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="35685" checksum="096691E58FAEC6EC" modified="2011-04-05" version="1">MKRFQSLLLVLALFLVSLSACAPAATPTPTPTLAPTATAVATATIAPTPTFTVTVAPTIEVPDGMGGTLTLEAPAQKIISLAPSNTELLFAVGAGSQVIAREEFSNYPQEAQALPSVGGSMGKYDTEKMVSLQPDLVLASPLTAPETLQALKDLGFTLVVVPNPITLEDMYANIELVGKITGHENEAQELVASLKDRQQKILAVVAKASSKPKVFYELDASQDPAKPWTSGPGTFIDQLITLAGGVNVGASLQGEWAQISLEELLVQNPDVILLGDANWGVTPESVAQRTGWEKLDAVKNGKVFPINDDLISRPGPRQIDGLAELVRLLHPELASQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV5</accession>
    <name>E8MZV5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_02560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62290">
        <property type="protein sequence ID" value="BAJ62290"/>
        <property type="gene ID" value="ANT_02560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02560"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="FATWIYA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="177" mass="20497" checksum="AE618189BFFECC32" modified="2011-04-05" version="1">MQELELTQSAQAQALTLDWESVYTELLPRVYNYFRYRGLEDEVAEDLTAQTFEKAWRKRASYRHDLAAFSTWVLRIAHNVAMDYHRTHGRQVSLEEMEVHGGEAHPEESMMARDEILRLRRLLAQLPPREQELVALKYGSGLTNRTIAQMTGLSESNVGTILHRVVQMLRAQLKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW0</accession>
    <name>E8MZW0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_02610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02610"/>
    <dbReference type="EnsemblBacteria" id="BAJ62295">
        <property type="protein sequence ID" value="BAJ62295"/>
        <property type="gene ID" value="ANT_02610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02610"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_0"/>
    <dbReference type="OMA" id="IYYWPLA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="43"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="407"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="440"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="661" mass="72050" checksum="FBC02054C98920CF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW4</accession>
    <name>E8MZW4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ordered locus">ANT_02650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558696.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02650"/>
    <dbReference type="EnsemblBacteria" id="BAJ62299">
        <property type="protein sequence ID" value="BAJ62299"/>
        <property type="gene ID" value="ANT_02650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02650"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_2_0"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="67"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="286" mass="31055" checksum="C9DD3F3187EA68AA" modified="2011-04-05" version="1">MERSLISARIQQRIGFSLLGVVTFVTVLPVLLIIGYIILKGMPAISWEFLTAMPRNGMRDGGILPAIIGTFYLTLGTAIFSVPLGIAAAIYIAEYAPDNFLTRLIRIAIINLAGIPSVVYGLFGLGLFVLFLRLGTSILAASLTLSIMTLPVIISTAEEALRSVPQAFRTVSISLGATRWQTIWRIVLPQAMPGIITGIILGLERAAGETAPILFTGAAFFLPRLPQSPMDATMALPYHIFVISTSVPGMPIQIQYGTVLVLLVFVLGMNLIATFIRQRARAKRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N028</accession>
    <name>E8N028_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3 7">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">leuA</name>
        <name evidence="9" type="ordered locus">ANT_03290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558760.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03290"/>
    <dbReference type="EnsemblBacteria" id="BAJ62363">
        <property type="protein sequence ID" value="BAJ62363"/>
        <property type="gene ID" value="ANT_03290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03290"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_0_1_0"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
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        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
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        <property type="entry name" value="PYR_CT"/>
    </dbReference>
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        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <end position="275"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="541" mass="58006" checksum="01E59D5DC0E671FB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0A2</accession>
    <name>E8N0A2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561005.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26250"/>
    <dbReference type="TCDB" id="9.B.363.1.1">
        <property type="family name" value="the divergen pap2 (pap2) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64651">
        <property type="protein sequence ID" value="BAJ64651"/>
        <property type="gene ID" value="ANT_26250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26250"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073969_1_1_0"/>
    <dbReference type="OMA" id="QPIEVFF"/>
    <dbReference type="OrthoDB" id="1864362at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF212"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02681">
        <property type="entry name" value="DUF212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="149" mass="16320" checksum="D5D2F2E6D10277A5" modified="2011-04-05" version="1">MFQDLLSNHVLWISLIAWGLAQFLKPFLEYLETRRWVWGLWFSSGGMPSSHSALIVSAMVAIGLFEGFNTPLFALAVAMAMIVVYDAAGVRREAGKHAERINLLIEEFLAGHPISEQELKEVIGHTPGEVIAGVVLGILCALIGFGIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E7</accession>
    <name>E8N0E7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561048.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64696">
        <property type="protein sequence ID" value="BAJ64696"/>
        <property type="gene ID" value="ANT_26700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26700"/>
    <dbReference type="eggNOG" id="ENOG5030B14">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_996074_0_0_0"/>
    <dbReference type="OMA" id="EKPYAPQ"/>
    <dbReference type="OrthoDB" id="1779550at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="30473" checksum="B90179DBCCE7B107" modified="2011-04-05" version="1">MENPLTQHKWFMPFMYFLLVVIAFLPLITAVPYDPRNTSEVIFEILSYALIPYANWGIAFHILTLLVIGIAIWKPRSGGRLIAGYFGLNYLVIAFTQTRALTPTYGYAIHTGALIVEVLLGLLWLWVAWKDKLRISFQNVPFWRWLLLPLAILTFWSPIAMQGNRIVPNFDPLLLLTSPDYGLAFCFMTPVFLFLLILAYPQVDLLALRLTAFNALLYALFNLNHWAVPERLWMGVMHLPLLILSLTALVLAHKRRPVNRLQSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F2</accession>
    <name>E8N0F2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561053.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26750"/>
    <dbReference type="EnsemblBacteria" id="BAJ64701">
        <property type="protein sequence ID" value="BAJ64701"/>
        <property type="gene ID" value="ANT_26750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26750"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004435_1_1_0"/>
    <dbReference type="OMA" id="AHVHEQT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTAD" evidence="1">
        <location>
            <begin position="110"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1210" mass="136696" checksum="5259AC6BB1F4532E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H5</accession>
    <name>E8N0H5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_26980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561076.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26980"/>
    <dbReference type="EnsemblBacteria" id="BAJ64724">
        <property type="protein sequence ID" value="BAJ64724"/>
        <property type="gene ID" value="ANT_26980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26980"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061572_0_0_0"/>
    <dbReference type="OrthoDB" id="1523005at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012286">
        <property type="entry name" value="Tetrahaem_cytochrome"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14537">
        <property type="entry name" value="Cytochrom_c3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225191" evidence="8">
        <location>
            <begin position="28"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_c3_2" evidence="9">
        <location>
            <begin position="73"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="399" mass="44440" checksum="0FDCEF384697B16F" modified="2011-04-05" version="1">MKPFAKSWMALLLAGFLLVTLSSVAHAATLSQESLPGNEVCLACHQKPGQVLTMDNGEQLYITILPEEYGKSIHAKSGVACAMCHSDMFGYPHPAKDFSSLRAYRKQYQNTCKVCHADKYELDSVHRRAFESGNELAPTCIDCHNPHTQAQVKDEQGNLIPEELGKSPEVCSKCHFGVYQEYEQSVHGKAAKAGNPDVPVCITCHGLHVVEEPHTAQFRLASPKMCGECHSDPEIMGKYGLSTDVYNTYVADFHGSTVTLFERLSPDQQTNKAVCYDCHGVHNIGDVDDPVVGLGMKQNMLKACQKCHPDATENFPDSWMSHYRPDREKYPLVYYVNLFYKIFIPLVLGGMAVFVASDVYHRVRRALNRRKPAEPAQPATEPQEKPETSETAQESGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J1</accession>
    <name>E8N0J1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64740">
        <property type="protein sequence ID" value="BAJ64740"/>
        <property type="gene ID" value="ANT_27140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27140"/>
    <dbReference type="HOGENOM" id="CLU_3387754_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="32" mass="3941" checksum="4322BFAE7E3E703D" modified="2011-04-05" version="1">MRQMLLRYRNLHDDPLHRIGENVCSKYIKKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J8</accession>
    <name>E8N0J8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_27210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64747">
        <property type="protein sequence ID" value="BAJ64747"/>
        <property type="gene ID" value="ANT_27210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27210"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878931_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="316" mass="36185" checksum="006AB124674C9F19" modified="2011-04-05" version="1">MVDSLLKKPFRKSNDNVNRIYHIINSRAAYQAAMGLGRTLPPVVGYALADLLSGLMSRMPHLALVRAVRLNQWIVHDRQVDSRQLDRLVRETLRSAARAVYDFAHWKDHPQVLKKVVRVEESFRQVAEKARRREHGVILALPHMTNPDLLGWVSAPLFGRLTAIAPNRLMEGYQVQNQLRRQVGIEVIPGSLEAVRTALARLREGEAVVFGVDRPYADSAFRPRFFGLPAALPVAHVRVALKLDLPIYVVGAALKEDKQISLWATEYRLHRLPNPQEEILVNAERVLEVVMDNIRQYPVQWNMTFPVWPDWMERVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U1</accession>
    <name>E8N0U1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2-oxoglutarate ferredoxin oxidoreductase gamma subunit</fullName>
            <ecNumber evidence="3">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558882.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62486">
        <property type="protein sequence ID" value="BAJ62486"/>
        <property type="gene ID" value="ANT_04520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04520"/>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_0_1_0"/>
    <dbReference type="OMA" id="EVSWMPS"/>
    <dbReference type="OrthoDB" id="1777574at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="181" mass="19555" checksum="411834D54E6D2CE0" modified="2011-04-05" version="1">MQTEIIVSGFGGQGVLFAGQLLSYAAMDAGKEVTWIPSYGPEMRGGTANCTVVISDEEIGSPLVKHPQAVIAMNLPSLDKYEPLVKSGGVLIVNASMVNRQPARTDIHWVMVPGNEIAEELGDRRMTNMVMLGALLANLPILSLEALVRTLEAHMPARHQRLLPLNIEAIKRGAEYLAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N119</accession>
    <name>E8N119_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase, subunit I</fullName>
            <ecNumber evidence="8">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_05300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the heme-copper respiratory oxidase family.</text>
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        <property type="gene ID" value="ANT_05300"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_0"/>
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    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
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        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="5" id="KW-0813">Transport</keyword>
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            <begin position="12"/>
            <end position="32"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="62"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="141"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="404"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="474"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="508"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
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        <location>
            <begin position="84"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="618" mass="68576" checksum="0D4CE8B35275BA89" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N131</accession>
    <name>E8N131_ANATU</name>
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        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
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            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="BAJ64774">
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001279">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="119" mass="13441" checksum="FA9807E987E9F1DD" modified="2011-04-05" version="1">MRSSSLFTIVDVGYRSTHYWVISAGRSRFLVDIGWPGTLGMMKTNLKKMGMALNEIRYAMATHYHMDHAGLAEELKREGVPLLVLDVQVSAIPLMKMWMKPQDHYVEITDEGNVVITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N160</accession>
    <name>E8N160_ANATU</name>
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        <recommendedName>
            <fullName evidence="2">CHAD domain-containing protein</fullName>
        </recommendedName>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ64803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="340" mass="39686" checksum="7B960C8037B3FFC4" modified="2011-04-05" version="1">MKASACLCAYGARVILKHLKAFQREWQGVHTGAEDIEHIHRMRVASRRLRATLPLFALCFPGKKVDNWMKHIRRVTRALGGARDADVQIARVQAFLDTVEDIRLRPGLQRLLLRLRQARAGHQPAVTSALEKLAERGILDEMKILLEEHLTMCNEDTPPDAELYTLARTEITRRLDAFLAYDAIVPLPERVQELHELRIATKWLRYTAEAFAPLYPDELARWLSILRDIQERLGQIHDDDVWLTFLPAFLEEERQRVEMFYGYTRPFRRLIAGVQAFEQACREDRERLYRAFVPDWQTWQAEGIWDALREQVNLPQVNPEEVYPPLRQDENRNDSVTDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C5</accession>
    <name>E8N1C5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR_Cas6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ordered locus">ANT_28420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561213.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64868">
        <property type="protein sequence ID" value="BAJ64868"/>
        <property type="gene ID" value="ANT_28420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28420"/>
    <dbReference type="eggNOG" id="COG5551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050021_0_0_0"/>
    <dbReference type="OMA" id="GCITREK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="1">
        <location>
            <begin position="199"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="36751" checksum="ED53D9B7F4D3CAF0" modified="2011-04-05" version="1">MADFPLTFTRLRFECLAEDALRFGEYRAGSNLRGALVNIMRRAACPYSVPALAGSAPYAPDPAHTATCPVCWLVAANESPGVERRGYVLTPPLNAPSFLPAGERFAFHLTLVGEAQRFLPYFVLAVPEMGRVGVGAGRGRFTLRRIVAERLNGAEEIILDEGETVLRPNFSMQSHCDVLARAAGLLPEGDPQQILELRMRFLTPMRLVWNERLVKTPDFAILFARLLERVDELAQQFAGAPRRAHEERIHFSQLALQVRLIEQDTRWVEVSSGSSRTGTQTWISGWVGSARFAAPRWVWRELLPWLVWGEAVQVGKDTVKGNGVLRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1D7</accession>
    <name>E8N1D7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561225.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64880">
        <property type="protein sequence ID" value="BAJ64880"/>
        <property type="gene ID" value="ANT_28540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28540"/>
    <dbReference type="eggNOG" id="COG1367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887624_0_0_0"/>
    <dbReference type="OMA" id="FRGAMRY"/>
    <dbReference type="OrthoDB" id="1800053at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007522">
        <property type="entry name" value="CRISPR-assoc_prot_TM1795"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01894">
        <property type="entry name" value="cas_TM1795_cmr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="34033" checksum="AEDBA8AA736EA8D3" modified="2011-04-05" version="1">MTDWKQQVRVQLETVTPLFLGGADPRGEPELRPPAFRGAMRYWFRAALGGVIGDSNLDGLRQLEREVFGDAEYGSPIAIQVRQKALPSASYPILPHKTPSGSRRAFNPKQQFEVILGTTRPVDPLVWVNACMSFNLAVWLGGLGLRSRRGAGSLRVVGSTDSSLVPVFPDDPEKLQKLVSVIIRSALERGKTLAEKYGVPVVSSLPSSPAKFACFAQGAEIHFVKDWARTPQDAMAAVMRKMPKADYLGGISPRQGSPLWVNILYASQAYHLLLTVLPSRLASGRQDYQKVSQLLQSLGGQKIQIKGWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K7</accession>
    <name>E8N1K7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05780"/>
    <dbReference type="EnsemblBacteria" id="BAJ62612">
        <property type="protein sequence ID" value="BAJ62612"/>
        <property type="gene ID" value="ANT_05780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05780"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_0"/>
    <dbReference type="OMA" id="QEADDVW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="155" mass="16405" checksum="0537EC297BDC89E0" modified="2011-04-05" version="1">MGYHRITLTVNGVMELVDVPSNMTLLQMLREKLGLTGTKNGCASGECGACTVMLNGEPVNSCMVLAVECDGADVVTVEGLAKNGQLDPLQEAIIETGGVQCGFCTPGILISSRALLNRNPKPTEFEIREAISGNLCRCTGYNRIVEAVKKVAGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1U4</accession>
    <name>E8N1U4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559094.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06650"/>
    <dbReference type="EnsemblBacteria" id="BAJ62699">
        <property type="protein sequence ID" value="BAJ62699"/>
        <property type="gene ID" value="ANT_06650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06650"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_0"/>
    <dbReference type="OMA" id="IGFTSWV"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="207"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="416" mass="45881" checksum="6AB7BC9EAB650405" modified="2011-04-05" version="1">MMHTIRQVFRSGKFVTGFVIFVSLLLIVLIYPLLVPDDPLAIIGLGTFFPPGIYVNVYDSVNTAPYTLNLPEAATNRIANKLGAKERQDMKEWLLAAGIPEEEIDIEDTAKLLDLWEKNYDPNKNIEGMTLAKMRYYQRLNNSLKGLLATEGLIVALPNAQTGTLEQVKVIEQSDYVNVREVPNVRVLPLGTDNFGRDVLTELVKAAGVSLQIGFVAGLIATLIGLVLGLLAGYIGGTVDDIIMFFTNLLIVIPSFVLLILISFSIGQDKRGAFTIATVIGFTSWVWTARAVRAQVLSLRNRDHVNLSRLSGHSTLYIILNDILPYIMSYVVMALILQISSGILAEAGLSILGLGPRTTEVPTLGLMMNWAMIYQAHVLGKWWAYLPVLVTIALITFSMNLMNTGLDQVFNPALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W5</accession>
    <name>E8N1W5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">priA</name>
        <name evidence="11" type="ordered locus">ANT_28860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561257.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28860"/>
    <dbReference type="EnsemblBacteria" id="BAJ64912">
        <property type="protein sequence ID" value="BAJ64912"/>
        <property type="gene ID" value="ANT_28860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28860"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_3_0_0"/>
    <dbReference type="OMA" id="MISKGHD"/>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="310"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="841" mass="93652" checksum="93D2239BD05B4773" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z3</accession>
    <name>E8N1Z3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_29140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29140"/>
    <dbReference type="EnsemblBacteria" id="BAJ64940">
        <property type="protein sequence ID" value="BAJ64940"/>
        <property type="gene ID" value="ANT_29140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29140"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_7_0_0"/>
    <dbReference type="OMA" id="KELKGHW"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="254" mass="26543" checksum="4EA604DB7DA999E0" modified="2011-04-05" version="1">MEWTGYLWIALAAVAAGAINALAGGGTLITFPALTAVGVPAVVANVTNTVALLPGYLGGTWAQWEDLQGQSRRTRALLPAALIGGLLGGFLLLLSGERLFRALVPYLILFASLLLAVQDEIRKRVFSPARMERHARAPEALAVIPVLLASVYGGYFGAGLSVIVLAVLGLVLEDSLTRLNALKQGVAFATNLAAALFFVFSGKVLWSAALVMAVGALLGGVLGGKLAGRVKPIVLRWLVVSIGIVVSILYFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N218</accession>
    <name>E8N218_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561309.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29390"/>
    <dbReference type="EnsemblBacteria" id="BAJ64965">
        <property type="protein sequence ID" value="BAJ64965"/>
        <property type="gene ID" value="ANT_29390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29390"/>
    <dbReference type="HOGENOM" id="CLU_1709476_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="153" mass="17379" checksum="A949CE2B505A66FC" modified="2011-04-05" version="1">MDSDRLSPAQQRALRASLLSFEKALRSALEHLSQPVQPGILYRRSLRLEETERRALQEQIQQTLHDLETFVGRLGLEAVDEPLERIIAAEMSLCWESLQESTSSRLRAYGELPPALARRLDPALEEFARSALEIARRVSSNGRIVREITDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N232</accession>
    <name>E8N232_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561323.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64979">
        <property type="protein sequence ID" value="BAJ64979"/>
        <property type="gene ID" value="ANT_29530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29530"/>
    <dbReference type="HOGENOM" id="CLU_2230871_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="105" mass="11875" checksum="442B9A8DB16C05DE" modified="2011-04-05" version="1">MDSEQNAPICPNGEHQWVDYQCVYCGAQKPEALDEIFQELLALSSDMSLYEIGLREKRARKLGEILNEWGGFPLMVSMCEAVGAVNLLSGRLVELWWHGMGTWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A3</accession>
    <name>E8N2A3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30240"/>
    <dbReference type="EnsemblBacteria" id="BAJ65050">
        <property type="protein sequence ID" value="BAJ65050"/>
        <property type="gene ID" value="ANT_30240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30240"/>
    <dbReference type="HOGENOM" id="CLU_3195436_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="45" mass="5242" checksum="FF7623ED88B00EF6" modified="2011-04-05" version="1">MLIVCSVPRHRLLGKIPMRRFTGIRELRYNVPNAGMNEGTAWHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D8</accession>
    <name>E8N2D8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559138.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62744">
        <property type="protein sequence ID" value="BAJ62744"/>
        <property type="gene ID" value="ANT_07100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07100"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="OMA" id="RIDHKAT"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="243"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="495" mass="54651" checksum="5BBF60E2FA60337E" modified="2011-04-05" version="1">MNTSVVLSLKSITKKYPGVLALDRVSLDFFAGEVHALVGENGAGKSTLIKAIAGAINLDGGVIQIGGQDYHQMTPHLSRSAGIEVIYQEFNLVPTMSVAENIFLGEKPNTLNFVNYRLMKNQARELFRLFDVDMDPDALVQDLSPAQQQIVEIAKAVSKNVKILIMDEPSAPLSVSEVERMFEIIRQLKRKGVTIIYISHRLEEIFKISDRVSVLRDGKYVATKLTSETNREELIRLMVGRELKETYPARTNPPGEIALEVKNLSGNGVRDISFVVRKGEILGVAGLVGAGRTEMAMLIFGAAPIESGEIRANGKLVRIRSPQDAIQHRIGLLTEDRKGKGLFLEMPVGWNITFPIVRKLSRFGVVDTQKEKSISEYYWQHLNIKTPSLEERVINLSGGNQQKVVLAKVLAADSAILIFDEPTRGIDVGAKQEIYHLMCELANNGNAILMISSDMEELLGMSDRIIVLCEGKLAGEVSKDNFSQDLILDLASGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2E4</accession>
    <name>E8N2E4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ethanolamine utilization protein EutH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eutH</name>
        <name evidence="2" type="ordered locus">ANT_07160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559143.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07160"/>
    <dbReference type="EnsemblBacteria" id="BAJ62750">
        <property type="protein sequence ID" value="BAJ62750"/>
        <property type="gene ID" value="ANT_07160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07160"/>
    <dbReference type="eggNOG" id="COG3192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061142_0_0_0"/>
    <dbReference type="OMA" id="FGDHLGF"/>
    <dbReference type="OrthoDB" id="1315713at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034228">
        <property type="term" value="F:ethanolamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007441">
        <property type="entry name" value="EutH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40089">
        <property type="entry name" value="PTHR40089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04346">
        <property type="entry name" value="EutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019466">
        <property type="entry name" value="EutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="359" mass="37670" checksum="DC6FA1C48D6019C6" modified="2011-04-05" version="1">MSINEIIIWLMAIFMVIGAIDRILGNRFGLGEEFENGFNALGPLGLAMVGVISLAPVLASVLRPIIVPVYQFLGADPAMFATTLLANDMGGYPLAKQLAIDPEAGLYAGIILGAMMGPTIVFSIPVALGLIPAEDRKYLALGMLAGFITIPLGCIAGGFTAGWGADVVLGNLVPVVLVSVLIALGLWRFPDKMTTGFQYFGKGVVIMITIGLAAIVWETLTGVVIIPGMAPVWDGIQIIGSIGIVLLGAFPMVKVITKVFKKPLMALGRRMGMNDIAAAGMVATLANNIPMFAMMKDMDVRGKVLNSAFAVSAAFTFGDHLGFTAGVERDLIFPMIVGKLTAGITAVLVAMLVAPKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2E5</accession>
    <name>E8N2E5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ethanolamine utilization protein EutM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eutM</name>
        <name evidence="3" type="ordered locus">ANT_07170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559144.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62751">
        <property type="protein sequence ID" value="BAJ62751"/>
        <property type="gene ID" value="ANT_07170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07170"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_3_0"/>
    <dbReference type="OMA" id="QFREGVN"/>
    <dbReference type="OrthoDB" id="1802372at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="96" mass="9830" checksum="6DF19EEDA4464817" modified="2011-04-05" version="1">MSGVQMIALGMIETKGLVGAIEAADAMVKAANVKLIGKEYIGGGYVTVMVRGDVGAVKAATDAGAAAAQRVGELVSVHVIPRPHSDVEMILPKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F0</accession>
    <name>E8N2F0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ethanolamine utilization protein EutE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eutE</name>
        <name evidence="4" type="ordered locus">ANT_07220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559149.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07220"/>
    <dbReference type="EnsemblBacteria" id="BAJ62756">
        <property type="protein sequence ID" value="BAJ62756"/>
        <property type="gene ID" value="ANT_07220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07220"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028794_3_1_0"/>
    <dbReference type="OMA" id="IAIKSRN"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="499" mass="53847" checksum="8FD4DB58986E6794" modified="2011-04-05" version="1">MALPENYDLDLRSIQEARHLAIQCREAQRAFAFATQEEVDRICSAMAEAGFREAARLGQLAHEETGYGVPRHKQLKNEFASKTVWDSIKDIKTTGVIRRDENRKVIEIAWPVGVIAALTPSTNPTSTAIYKILIAVKARNGIVVAPHPSARASTYEAVRIMAEAGEAAGMPHGLVSCMQNITLEGTQELMRHYAVSLILATGGSGMVRAAHSVGKPAIGVGPGNVPVYVDRSADVVKAASDIVNSKAFDCSVICSTEQCVVADKPIAEQLREEMKKNGAYWLPPEDVPAIEKLLFQAPGAMNPKAVGKTPQQLAKMAGIQVPLWARVLVVDLPGVGREYPLSGEKLTTVLGFMVEDGWRAGCERCIQLLKYGGDGHSLVIHARDEEVILAFGIEKPAFRIIVNSWGTMGAIGASTGVFPALTLAPGGLGGAIVSDNITTTHLMNIKRLAYEIQSPPSAAYTLAPDVKSENVQSLSSFAVSDEEIEDIVRRVLRQLEHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F9</accession>
    <name>E8N2F9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559158.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07310"/>
    <dbReference type="EnsemblBacteria" id="BAJ62765">
        <property type="protein sequence ID" value="BAJ62765"/>
        <property type="gene ID" value="ANT_07310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07310"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1045385_0_0_0"/>
    <dbReference type="OMA" id="CFYVLNV"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="169"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="261"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="292" mass="33494" checksum="FD3083E571ACC638" modified="2011-04-05" version="1">MNFVYQSPQNPNSHLTVKERNQASFPVRFLLQTNLIYGRVLDFGCGLGTDVEYLRNQGFEVTGYDPYYFPEIPQGKFDTILCLYVLNVLLPEEQAHVLMAISELLQPDGRAYFAVRRDIQKNGFRFHVKRGVNVYQCNVRLPYRSILLTKNAEIYEYRHYNRLPHSNPHNCPFCAPEEERELLTESASAYAILDKFPVSPGHALIIPKQHLASYFDLSFHTKTALWLMTDRVKELVSEKYHPDGFNIGINIGTSAGQTIPHVHVHLIPRYAGDVENPRGGVRGVIPEKKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L5</accession>
    <name>E8N2L5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07870"/>
    <dbReference type="EnsemblBacteria" id="BAJ62821">
        <property type="protein sequence ID" value="BAJ62821"/>
        <property type="gene ID" value="ANT_07870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07870"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529505_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="175" mass="19595" checksum="0CF3942F984C1010" modified="2011-04-05" version="1">MQTQPSEIVFSSTQEVVVYTRPRGNPTADWQELDRGPGIFRIPAGHEVMIRLKNIDNDDLKTLVRETAECPAITFLHLAENRKITDEGLQILQAFRNLSGLNLSSCDLTDQGLKALSAFPRLSHLNLSFCNRLTDAGLKHLRALPNLTYLDLQGCLKITHGGIARLGKRDLNIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N1</accession>
    <name>E8N2N1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_08030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559229.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08030"/>
    <dbReference type="EnsemblBacteria" id="BAJ62837">
        <property type="protein sequence ID" value="BAJ62837"/>
        <property type="gene ID" value="ANT_08030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08030"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224291_0_0_0"/>
    <dbReference type="OMA" id="VPMNDDV"/>
    <dbReference type="OrthoDB" id="633732at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026466">
        <property type="entry name" value="Fim_isopep_form_D2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="SSF49401"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04226">
        <property type="entry name" value="RrgB_K2N_iso_D2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1113"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="1472"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="1794"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="2097"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="2395"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="2539"/>
            <end position="2661"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="2670"/>
            <end position="2795"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="2804"/>
            <end position="2929"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="2938"/>
            <end position="3063"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="3072"/>
            <end position="3197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="3206"/>
            <end position="3330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="3">
        <location>
            <begin position="3498"/>
            <end position="3609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1595"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1932"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2644"/>
            <end position="2666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2779"/>
            <end position="2801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2913"/>
            <end position="2935"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3047"/>
            <end position="3069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3181"/>
            <end position="3201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="3822" mass="389707" checksum="3FD56CD003D803C3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N8</accession>
    <name>E8N2N8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_08100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559236.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62844">
        <property type="protein sequence ID" value="BAJ62844"/>
        <property type="gene ID" value="ANT_08100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08100"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_968543_0_0_0"/>
    <dbReference type="OMA" id="ADKHDTH"/>
    <dbReference type="OrthoDB" id="1210778at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="287" mass="32210" checksum="321DF6D35751A71F" modified="2011-04-05" version="1">MKFHQPGAEIFIPDGVSVEEALTRTTHLCIAAHQDDVEIMAAEPILSCFQHPDQWFTAVIVTDGRGSPRDGMYANTSDEEMRLIRFKEQRKAAVVGEYSALIFLDYPSKVIKDAAQEAPIADLLAILHATRPQQVYTHNLTDKHDTHVAVALRTLSALRHLPAKQHPQRVLGCEVWRSLDWMQDSDKVVMDVSQHENLQYALLGVFDSQIAGGKRYDLATMGRRRANATYFESHGVDITTGLAYAMDLTPLLLQPELSPAELVLTLIQHFQEDVLKRLQRMGNSPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P9</accession>
    <name>E8N2P9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2-isopropylmalate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_08210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62855">
        <property type="protein sequence ID" value="BAJ62855"/>
        <property type="gene ID" value="ANT_08210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08210"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_4_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="461" mass="51344" checksum="6401E5F2C72D5E60" modified="2011-04-05" version="1">MVEILDSTLREGEQTPYVNFTVEEKVEIARLLDRVGVEMIEAGDPSVSPSVFEAVRRIASLGLRAEIVAHSLATRSGIEKAHACGVQRVVVFYPTSRIHLEAKMGKGEEEALHTIVEHVRFARSLGLKVRYTPEDASRTDFEFLVRACNSAIEAGADRISFADTLGILRPHEMFQRITELKKRLLPCRIDLHCHNDYGLALANALEGIRAGADCIHTTVNGMGERTGIPDLAETVLALHNLMGIQRYDVRALPQLSAYVERVSGFFLAPNKPITGLNAFSHKSGVHTNGVLKDPRTYESIDPAILGRERRIVIDKYTGKRAVAARLAEYGVEVDGEALEQIVEEIKRVGDERKILHDADIVEIAEQVTGKRYDIFPREIHAIVMVSVESHVYTGTVVRRLKNLKYVSSVYEITGEQDIAAYIKVPNTLELNNFIEELRAMSGVKQTETRVVLKKHAENGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Q9</accession>
    <name>E8N2Q9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">nuoC</name>
        <name evidence="6" type="ordered locus">ANT_08310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559257.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08310"/>
    <dbReference type="EnsemblBacteria" id="BAJ62865">
        <property type="protein sequence ID" value="BAJ62865"/>
        <property type="gene ID" value="ANT_08310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08310"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_6_0_0"/>
    <dbReference type="OMA" id="MERETYD"/>
    <dbReference type="OrthoDB" id="1735902at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 2 3" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="5">
        <location>
            <begin position="30"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="170" mass="20045" checksum="43D649EB9DE1719C" modified="2011-04-05" version="1">MDEKMRTVVEGLQSRFNLEVQEFRGEVTLIVPPEQIVAVAQTLRDEHGFEQLVDVTAVDYFPQQEPRFHVVYHIRSLAQTLIICLRVPLNGNFPSVSTVEKVYPGANWYEREVYDMFGITFEGHSDLRRILMPYDWQGHPLRKDYPLGYEEVQFSFNIDEVLKRKLRPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2R8</accession>
    <name>E8N2R8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxygen-independent coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6">1.3.98.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_30420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.98.3" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561409.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30420"/>
    <dbReference type="EnsemblBacteria" id="BAJ65068">
        <property type="protein sequence ID" value="BAJ65068"/>
        <property type="gene ID" value="ANT_30420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30420"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_3_1_0"/>
    <dbReference type="OMA" id="LMCNLEL"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051989">
        <property type="term" value="F:coproporphyrinogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="32"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ65068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="433" mass="49768" checksum="243F92178E3AC5E7" modified="2011-04-05" version="1">MIPDTLFSTTFRLASGVLLNLKSEHQPQLPAPQNGKAYMLYAHVPFCESLCPYCSFNRFLFDERKARQYFSSLREEMRMVAKRGYTFDTLYIGGGTPTILMDELVQIIDLARDLFGVREVSCETNPNHLDERLIDLLAPRVQRLSVGVQSFDDDLLRRINRYDRFGSGKEILERVQRTAPAFNAFNIDLIFNFPGQDLASIDRDLRLALESGATQITAYPLMTSPSVRRALEKTVGTVEFSREAEMYEHIVETLSSVFELSTAWTFSRKGKSLIDEYIVKSEEYVGVGSGSFSYLNGTLLVNTFSLQSYQRWVSERHAPIAGKRRFSRLDQMRYRFMMDLFGLRLDKRQWERDFGKPIEHCLPLELLAFEKAGAFAENNAEAITLTPRGRYLLVVLMREFFSSINRVRDQARRAVQSSEALRNPETRLSNAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N317</accession>
    <name>E8N317_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_31410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561508.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31410"/>
    <dbReference type="EnsemblBacteria" id="BAJ65167">
        <property type="protein sequence ID" value="BAJ65167"/>
        <property type="gene ID" value="ANT_31410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31410"/>
    <dbReference type="eggNOG" id="COG4133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005895">
        <property type="entry name" value="ABC_transptr_haem_export_CcmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43499">
        <property type="entry name" value="PTHR43499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="203" mass="23094" checksum="20CC9589C394680D" modified="2011-04-05" version="1">MSRLEVQSLRCGYHFPLLEISFHLEEGEYLFLKGANGLGKTTFVRTLVGILPPLQGEALFNGKPIHKHPSLSRDIFYLPEKIEVPEFLTPLQYVDLIREYYEVPPDHSRFHEGLALLNITPLSNVPMRNLSMGQKRRAQLLAAYVLQRKLTVLDDPLIAIDGEGEEFLARFIHHMNQHSMIVLTSRGDIATLHATEMTDFCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N338</accession>
    <name>E8N338_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_31640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561528.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31640"/>
    <dbReference type="EnsemblBacteria" id="BAJ65188">
        <property type="protein sequence ID" value="BAJ65188"/>
        <property type="gene ID" value="ANT_31640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31640"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_0"/>
    <dbReference type="OMA" id="NCRGYLE"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="10">
        <location>
            <begin position="31"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ65188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="217" mass="24202" checksum="770E178285EA82CD" modified="2011-04-05" version="1">MQPDQILKEIAQQVSECKRCQLHYSRKKAVPGEGPAQAEIMMIGEGPGFYENEQGRPFVGAAGKFLDELLEKCGIARKDVFITNVVKCRPPGNRDPQPEELEACNAYLERQIEAISPKVIVTLGRFSMAKFLPGVKISEVHGQSFWRNGRLIVPMFHPAAALHQPSLKASVERDFARLSEYVQAARQRMQAAEKPIAVEEKTGETPAKDQPTQLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N350</accession>
    <name>E8N350_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative deoxynucleoside kinase</fullName>
            <ecNumber evidence="4">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_31760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561540.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31760"/>
    <dbReference type="EnsemblBacteria" id="BAJ65200">
        <property type="protein sequence ID" value="BAJ65200"/>
        <property type="gene ID" value="ANT_31760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31760"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_0_0"/>
    <dbReference type="OMA" id="IEEWSFQ"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="3">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="216" mass="25496" checksum="4300050FAC184594" modified="2011-04-05" version="1">MYLAIEGVIGVGKTTLARMLQPAFQANLLLEVFEENPFLSKFYEDRARYAFQTQIFFLLSRYHQQRRGIPELTAGGRNLISDYTFEKDALFARINLEGDELEMYYRVHEALAEKIQPPDLIVYLRATTDLLMERITRRDRVYERNMERAYIDELNHAYDEFFLSPDRLSSPVLTLDANALDFVRYPEDLRWIENRIRQALELPPYQPELPLPLHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E6</accession>
    <name>E8N3E6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KDP operon transcriptional regulatory protein KdpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_09260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559351.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62960">
        <property type="protein sequence ID" value="BAJ62960"/>
        <property type="gene ID" value="ANT_09260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09260"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_0"/>
    <dbReference type="OMA" id="SYPRRVW"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="229" mass="26144" checksum="4740DFD8825A1A04" modified="2011-04-05" version="1">MSDTGLRILVVDDERAIRRYLRTSLTALGYEVLEAATGNEALQSAMTEHPDILILDLGLPDIDGVEVVRRIREWSNVPILILSVRDREDDKVVALDAGADDYLTKPFGIKELLARIRVAIRHRTPDQQDTVFEVEDLRVDLGKREVFVQGNRVALTPTEYDLIKVLVQHAGRVLTHNQLLRQVWGPAYENEAHLLRVNISNLRRKIEPNPDQPRYILTEPGVGYRLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H0</accession>
    <name>E8N3H0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62984">
        <property type="protein sequence ID" value="BAJ62984"/>
        <property type="gene ID" value="ANT_09500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09500"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_5_0_0"/>
    <dbReference type="OMA" id="LHASHNI"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="291" mass="31778" checksum="52C746B602CB33DE" modified="2011-04-05" version="1">MNSGKGTMMMSPKQKIILFLVLTFLFSGVFYALILTSGNLEGWTLALMWCPGIAALITQWVSHKNLRGLGWRLRPWRFLLLGYGLPILYGLLVYGVVWASGAAPFKGQEMAQDMAAQMGTSVNTTGFLVNYVVMMGTLGMLGSIFAALGEEIGWRGLLVSELARLTSFPGAALISGAIWALWHFPLILFSEYNNAGAPRWLGMIFFTVMVLGISFALAWMRLKSGSFWGAVILHASHNIFIQGVFTPLTGQSALSPYLIDEFGVGLALVGLALILIFWSKRAEVEQAPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I2</accession>
    <name>E8N3I2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdenum ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_09620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559387.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09620"/>
    <dbReference type="EnsemblBacteria" id="BAJ62996">
        <property type="protein sequence ID" value="BAJ62996"/>
        <property type="gene ID" value="ANT_09620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09620"/>
    <dbReference type="eggNOG" id="COG4152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="TQRFSYW"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="301" mass="33917" checksum="C1839DD0723DB3E5" modified="2011-04-05" version="1">MATIQAHEIVKRFGNQTAVNQVTFNVEAGEIFGLLGPNGAGKTTTIRIILDIFKPDSGSVEVLGGTMTEDKKNRIGYLPEERGLYQDISLEMCLNYLVRLKGLKPSYAANRVSELMKQFDLYDHRKKKVKELSKGMQQKAQLIATLAHEPDLIIVDEPFSGLDPVNTQMVKDLLRQEREKGKTIVMCTHQMHQVEELCDRLVLINHGKVMLYGKINEIRRNYASHEVIIHPLNDLPASLPGVVQVEPVNSGYLLHLERNSSPQEILKYLVETGVALEKFEIAMPTLDEIFIQVVTAQEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M6</accession>
    <name>E8N3M6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rplW</name>
        <name evidence="10" type="ordered locus">ANT_10060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559431.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63040">
        <property type="protein sequence ID" value="BAJ63040"/>
        <property type="gene ID" value="ANT_10060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10060"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_1_0"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="99" mass="11274" checksum="F139DC687482892F" modified="2011-04-05" version="1">MSTIYDVLRRPLITEKTNYQAGKLHQYVFEVADDATRTLVKDAVEKIFNVTVLRVNLINVPAKQSRRGRSRRVVVTREGYKKAIVTLAPEDSIPLFEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N3</accession>
    <name>E8N3N3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rpsQ</name>
        <name evidence="6" type="ordered locus">ANT_10130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559438.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10130"/>
    <dbReference type="EnsemblBacteria" id="BAJ63047">
        <property type="protein sequence ID" value="BAJ63047"/>
        <property type="gene ID" value="ANT_10130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10130"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_0"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="90" mass="10174" checksum="5E94EDE458A5E65A" modified="2011-04-05" version="1">MNTRRRMTGLVTSNKMMKTVVVQITRTFQHPLYKKVVHSIKKVKAHDELGCEVGDVVQIVESRPLSAQKRWVVEKIVRKSSGADVVEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Q9</accession>
    <name>E8N3Q9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_10390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559463.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63073">
        <property type="protein sequence ID" value="BAJ63073"/>
        <property type="gene ID" value="ANT_10390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10390"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690099_0_0_0"/>
    <dbReference type="OMA" id="FEREPAQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="399" mass="43858" checksum="3B9BCD6DA22E7D0D" modified="2011-04-05" version="1">MSAFEQRFTFPENGWLVLQSLGDVLIQGVKQPDVLLRIPEEGMAQVQSQTDRLFISAQSDVEIFVPEQAKIRLEGVTGDASVVGVLGYMEIARVNGDLAMRSCDKVDIGVVNGDVELLQVAGPIVLRRAGGDLFVESRNRVVAEQVGGDVTIRADGLVRAKAGGDLNIQLISVNVEEVHARCGGDLLITAPSGLGAQLDVNSGGFSITLRLPDQTLNLDQPHYSTTLGNGKTLLRLVAGGDVSVQLGDSILQEQKVPRKSFTADFVGGIEIPDLSPFVEDKIRQKMEHATRKAEERARRAEERVRRAMERVEQAQRQVHRRNRWFGFWYEAGKNPEDPAVPKPPEVPKAPEAPETFGTSFSQVTNEERLLVLKMLQEHKITVEEAEQLLAVLDGDLDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3U1</accession>
    <name>E8N3U1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_10710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559495.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63105">
        <property type="protein sequence ID" value="BAJ63105"/>
        <property type="gene ID" value="ANT_10710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10710"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_0"/>
    <dbReference type="OMA" id="GCESFHA"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="100"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="562" mass="64516" checksum="981B6DEDDFB8A6FB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3U6</accession>
    <name>E8N3U6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">asd</name>
        <name evidence="2" type="ordered locus">ANT_10760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.11" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559500.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10760"/>
    <dbReference type="EnsemblBacteria" id="BAJ63110">
        <property type="protein sequence ID" value="BAJ63110"/>
        <property type="gene ID" value="ANT_10760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10760"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_0"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="352" mass="38296" checksum="C7EFA2D486CC5C7C" modified="2011-04-05" version="1">MKRIPVGVLAATGSVGQRFIQLLEGHPWFEVVAVTGSDRGTGKPYGEVCRWLLPGDMPERVRNLPVLPTSPEAVQVPLVFSALPAEIAQDAEPAFARAGIAVCSNASAYRKDPDVPILLPEVNPDHAHLIPVQQSRHQWTGWIATNPNCTSTGMTVALKALQDRFGLKRVFAVSMQALSGAGYPGVPAMDIIDNIIPFISGEEDKVEWEPRKMLGTLGTGGIQLADFGISAHTNRVNVSDGHTVCLTIELEMRASAEEVKRTLREYQAPEIACNLPSTPLPPILVREEENRPQPRLDRMTGNGMTTVVGRVRADSLFDIRLVVLSHNTIRGAAGGSIYNAELLYRMGYIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V2</accession>
    <name>E8N3V2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_10820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
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        <property type="protein sequence ID" value="BAJ63116.1"/>
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        <property type="protein sequence ID" value="BAJ63116"/>
        <property type="gene ID" value="ANT_10820"/>
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    <dbReference type="KEGG" id="atm:ANT_10820"/>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P"/>
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        <property type="entry name" value="HisK_dim/P_sf"/>
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    </dbReference>
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        <property type="entry name" value="PAS-like_dom_sf"/>
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        <property type="entry name" value="PAS_fold"/>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BCTRLSENSOR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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            <end position="90"/>
        </location>
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            <end position="358"/>
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    </feature>
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        <location>
            <begin position="380"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="450"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="669" mass="76670" checksum="C038111C8F6406C5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Y0</accession>
    <name>E8N3Y0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11100"/>
    <dbReference type="EnsemblBacteria" id="BAJ63144">
        <property type="protein sequence ID" value="BAJ63144"/>
        <property type="gene ID" value="ANT_11100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11100"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_17_0_0"/>
    <dbReference type="OMA" id="PDFEEGW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="163"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="396" mass="44398" checksum="15C49A6AAB21C149" modified="2011-04-05" version="1">MSDEVGFITMAGERATGEAPEIGVGMLGYAFMGKAHTNAFKKIPYMVYPPPAIPKLVAICGRNEEAVREAAKRYGYQRYTTDWKDLIRDENIQLFDNGGPNDAHAEPSIAAAQAGKHILCEKPLARNAREAAQMLEAVEKTGVVHMVAHNYRFVPAIRLAYDLIRSGQLGEIYHFRAVYLQEWIMDPNFPFVWRLDKNVSGSGALGDLGSHIIDLARFLVGEPRKVSALAKTFIKQRPVPGGGTGEVTVDDAFVATVEFENGAIGTLEASRFCAGRKNHQVIEINGSKGTLVFNLERFNELEVFWKDEQPRETQGFHNVLVSESYHPFWKHWWPQGHIIGWEHTFVHEIAHLLDCIVNHKPVAPFGATFEDGYKNAVICDAILQSAEQEKTIYIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N411</accession>
    <name>E8N411_ANATU</name>
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        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559563.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63175">
        <property type="protein sequence ID" value="BAJ63175"/>
        <property type="gene ID" value="ANT_11410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11410"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_4_2_0"/>
    <dbReference type="OMA" id="PFYFGTY"/>
    <dbReference type="OrthoDB" id="854580at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="684" mass="78328" checksum="12601444240B549D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N448</accession>
    <name>E8N448_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative two-component hybrid sensor and regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_11780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559600.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63212">
        <property type="protein sequence ID" value="BAJ63212"/>
        <property type="gene ID" value="ANT_11780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11780"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242168_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1530"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1459"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1660" mass="184920" checksum="D58C577C9294A5A7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N473</accession>
    <name>E8N473_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559625.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63237">
        <property type="protein sequence ID" value="BAJ63237"/>
        <property type="gene ID" value="ANT_12030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12030"/>
    <dbReference type="eggNOG" id="COG5660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179277_0_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="83" mass="9919" checksum="7312F7BFD6F76B68" modified="2011-04-05" version="1">MTESKDCERLLHSLGEYVEGELSEDLCAEIERHLLECHNCQVVVNTLRKTIELYHEEKEQDVMPPEVSRRLYMRLNLEDYLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K5</accession>
    <name>E8N4K5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase</fullName>
            <ecNumber evidence="3">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13370"/>
    <dbReference type="EnsemblBacteria" id="BAJ63369">
        <property type="protein sequence ID" value="BAJ63369"/>
        <property type="gene ID" value="ANT_13370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13370"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029703_1_0_0"/>
    <dbReference type="OMA" id="EKFEVPF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="175"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="451" mass="50601" checksum="036FE248F8E2CBE5" modified="2011-04-05" version="1">MTNAPMKPGAKPAPSAATGPSAPPFTPPPIVNLEDTGLSPLWLQDLILKVMYFQGYLTGYKIAEEIALPFSGVVDQILETLKREKLIEVRSSQMGLGEGAYLYAITGAGISRAREALERSQYAGPAPVPLGIYVESVLRQARSRVQVTSRVMRQVLSGLVLNENTFQALGPAVNSGTSIFLYGPPGNGKTSIARAIGNMLQAQSIYIPYAIYVDGQVIKLYDSVNHKLVQEEDTTYQGTGTLKAGSRRDPRWVRIHRPFIVTGGELTLAGLDLVFDDTLKYYEAPFQVKANGGILLIDDFGRQMVRPRDLLNRWIVPLENRIDYLTLHTGRKIEIPFDVLVVFSTNLPPKELVDEAFLRRLRHKIEIQDPTYEEYREIFRRVAAAKGVTYSDQGLAYLLQEWYVKRNRKLRANHPRDLCDQILDIAGYLNVEPEMSRELIDRAAKSYFVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L6</accession>
    <name>E8N4L6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_13480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559767.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63380">
        <property type="protein sequence ID" value="BAJ63380"/>
        <property type="gene ID" value="ANT_13480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13480"/>
    <dbReference type="eggNOG" id="COG4276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112936_1_0_0"/>
    <dbReference type="OMA" id="PIRARIH"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="146" mass="17165" checksum="D8F304D21695AACC" modified="2011-04-05" version="1">MKKFADVYNAGVPVEKIANFHFSKDAIKQLSPPGIGVQILSHQPLSEGSVTHFRLWIGPIPIEWEAQHQKVSWDSGFIDIQRKGPFKYWEHHHEWKSISKNETQMREYILCEHAPNLKGMLTRLLFNALAMKFFFWYRRKKISNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N9</accession>
    <name>E8N4N9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559787.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13750"/>
    <dbReference type="EnsemblBacteria" id="BAJ63403">
        <property type="protein sequence ID" value="BAJ63403"/>
        <property type="gene ID" value="ANT_13750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13750"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_0"/>
    <dbReference type="OMA" id="ILIFEAK"/>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="271" mass="30168" checksum="D12D0926B56289F1" modified="2011-04-05" version="1">MITSPANEQVKRIRRLQERKERERTGLFFLEGIRIVAEAAERGEAFETLIVSPDRLQSDFAWKLVENLRRNGTPILEVSSLVFERLSQKEGPQGIAAVVHQRWMPLGAVSVENGKPWVALDSVADPGNLGTILRTLDAVGGAGVILLDQSTDPYDPSCVRASMGALFDLHLVRTSFEQFRDWIKRQTGVALIGTSGAAKQDYHDFPYPSRLVLLMGSERLGLQPYHLELCDEVVRIPMVGRSDSLNLAVATAVVLYEIFNQQRQKSLGVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Q9</accession>
    <name>E8N4Q9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13950"/>
    <dbReference type="EnsemblBacteria" id="BAJ63423">
        <property type="protein sequence ID" value="BAJ63423"/>
        <property type="gene ID" value="ANT_13950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13950"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648621_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="160" mass="18245" checksum="1DEE7D6F34178CAF" modified="2011-04-05" version="1">MKNTSPLSPELLVPKMGDYLVEKGLITQNQLVLALQEQEQFRSREEKTPLLGKILVEKGFITQENLDRAIAEQILQYQNALQEANQKLEQRVKERTAELEKALEQLHSLNELIQPGGEHFSRTAYTLNPLNRLPGFASQRRFRPVKSTATRCPGSYSTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V8</accession>
    <name>E8N4V8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate guanylyltransferase</fullName>
            <shortName evidence="1">PEP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbiD</name>
        <name evidence="2" type="ordered locus">ANT_14440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine</text>
            <dbReference type="Rhea" id="RHEA:30519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="EC" id="2.7.7.105"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.105" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559854.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14440"/>
    <dbReference type="EnsemblBacteria" id="BAJ63472">
        <property type="protein sequence ID" value="BAJ63472"/>
        <property type="gene ID" value="ANT_14440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14440"/>
    <dbReference type="eggNOG" id="COG1920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076569_1_0_0"/>
    <dbReference type="OMA" id="RCDIDTP"/>
    <dbReference type="OrthoDB" id="1930370at2"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="214" mass="24320" checksum="348B55F46D7811E8" modified="2011-04-05" version="1">MNLWAIVPVKPLHQGKSRLAGMLSVEEREALNFSLLWHSLEVLSSVELISRVLVVSKDPKVLATAREYHAVTLHSEDDRLNLNLDLQKADFMAKWQGAQEILVLPADLPLITAWDVYQLIQKAQKPKAMVIAPDRNRDGTNGLLFNPAEGSRYSFGPGSFERHLAFAKKNGYRVEVYESETFALDLDTPEDLSLLYEKDPNFFQKFAKPIRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N517</accession>
    <name>E8N517_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559913.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63531">
        <property type="protein sequence ID" value="BAJ63531"/>
        <property type="gene ID" value="ANT_15030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15030"/>
    <dbReference type="eggNOG" id="COG2453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1451621_0_0_0"/>
    <dbReference type="OMA" id="HCQYGIG"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="2">
        <location>
            <begin position="103"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="186" mass="21169" checksum="ECE921F41039D42C" modified="2011-04-05" version="1">MIRKALQIVYRRLTEQGLRISLLWLYGRGLPALTGMPLLRFSRITPSLYVGPQYRKNGLRLLQSEGIHAVVNMREEKDDRDFGLAPAQYCYLPTPDDEAPTIEQLHQGVDFIQKIIQQGGKVYIHCGAGVGRAPTMAAAYFIHQGMSVEEAINTIRLVRPFIFITPPQIKQLYRYYEIVHSDGHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N522</accession>
    <name>E8N522_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N_BRCA1_IG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15080"/>
    <dbReference type="EnsemblBacteria" id="BAJ63536">
        <property type="protein sequence ID" value="BAJ63536"/>
        <property type="gene ID" value="ANT_15080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15080"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709119_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="N_BRCA1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N_BRCA1_IG" evidence="1">
        <location>
            <begin position="130"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="402" mass="43257" checksum="9E4D330E998A0046" modified="2011-04-05" version="1">MSKKRSYLLTYLGFIFFVLSGCNLLGTPQVDESQVATQSALIIQQAAQATATAYAMETEMANIATKAALLGSTFTPTFTAVPPSSTPLPTSTLPPTQTPLPSFTPFPTFTPVPTATPVPCNRAGFVADVTIPDGTIIPPGATFTKVWRLKNNGTCTWNTNYSAVFSGGDRMGGASPTPLNATVAPGETIDISITFTAPTTEGKYRSSWKLRAPDGTVFGLGSRDSAFYVDIEVKSGTSAYPFDFVLMVCSAEWSSGAGTLPCPGTDGDAKGFVLVQQKPQLESGVVDDEPALITQPQAITDGTLRGKFPGYKVQTGDKFKAIIGCSYNYKSCDMRFQLDYQIGTDPIQTLAYWNEVYDETFRSVEVDLSPLNGKTVRFILTVLANGEMKQDRGIWLAPRIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N526</accession>
    <name>E8N526_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_15120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63540">
        <property type="protein sequence ID" value="BAJ63540"/>
        <property type="gene ID" value="ANT_15120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15120"/>
    <dbReference type="eggNOG" id="ENOG5033F64">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2571717_0_0_0"/>
    <dbReference type="OMA" id="MFIKVTN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="82" mass="9474" checksum="BE92C647403F72DC" modified="2011-04-05" version="1">MHHMPTVLLHIMNEDPVAGEIEHLPSPTDNLVILKNPRKRDGKDLHYLEPNVSTVIWPIARINFIEVLPTGEEEEIITFIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A0</accession>
    <name>E8N5A0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559994.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63614">
        <property type="protein sequence ID" value="BAJ63614"/>
        <property type="gene ID" value="ANT_15880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15880"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091672_0_0_0"/>
    <dbReference type="OMA" id="HINIMSE"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="30720" checksum="0CBC70B93ABA0C5D" modified="2011-04-05" version="1">MNEERNEQILWRHLNSLPYFRAMVRAIEDRFYQGLELPRPILDLGSGDGHFTSVTFSQPLDVGVDPWWGPLLESKKYHVYRLLIQGDGGRLPFPSQAFSSVISNSVLEHIPHVDEVVKEISRILRPGGKFVFCVPNHRFPESVLGKQVLSRLGFSAWADGYSRFFNRISRHYHCDSVEVWDQRLSSAGFVIEKSWDYFSPKALHKMEIGHALGLPALFWKKIAGRWILLPQKWNLWFAYLIARESFSSPYSPDGVYSFYITRKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B6</accession>
    <name>E8N5B6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpsP</name>
        <name evidence="4" type="ordered locus">ANT_16040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560010.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63630">
        <property type="protein sequence ID" value="BAJ63630"/>
        <property type="gene ID" value="ANT_16040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16040"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_3_2_0"/>
    <dbReference type="OMA" id="KAGVWAK"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="115" mass="13337" checksum="F265F58C1F4E8BC7" modified="2011-04-05" version="1">MVRIRLRRTGLKKQPTYRVVVANSEAPRDGRFIEILGHYNPRTEPFTLEVDEDRVYYWMSVGAQPSEAVLKLFKSTGIMDRFARFKNGEPKEKLLEEARAYFATRGTNPKTRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q6</accession>
    <name>E8N5Q6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17440"/>
    <dbReference type="EnsemblBacteria" id="BAJ63770">
        <property type="protein sequence ID" value="BAJ63770"/>
        <property type="gene ID" value="ANT_17440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17440"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="OMA" id="MALGFCA"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="286" mass="31578" checksum="C0C0E16FB4E1668D" modified="2011-04-05" version="1">MKYPIALVTDSTCDIPQSWREEFEISVVPLSIHFGNDTYRDGVDLSPESFYERLEREEVHPTTSQPAPQDFINTFQALQDGGAKEIIVFTISSAMSGTIESARLAAQDFSIPIHIVDSKNNSMGLGWQVIAAARAREQGANAWEMLEVATKVRQKMAYYISLNTLKYLEKGGRIGNATKFLASLLQIKPLIYVDPSTGIVHPSIPARSRSAAIDGLFKEFFKHLNITSPMHITVLHNAARDEAEALAERVRETYHPAELFISIVSPVLGAHTGPKAIALCGYSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z0</accession>
    <name>E8N5Z0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_18280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18280"/>
    <dbReference type="EnsemblBacteria" id="BAJ63854">
        <property type="protein sequence ID" value="BAJ63854"/>
        <property type="gene ID" value="ANT_18280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18280"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065155_2_2_0"/>
    <dbReference type="OMA" id="AVDFICQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="194" mass="22057" checksum="C5D6B76D64885800" modified="2011-04-05" version="1">MNAITISRQMGAWGRKVAEATAELLGYRLVWREVINQAALRAGVPEVALATIDELGIMGIKPREEDLQAYHRAVRQIMEELVEEGRVVIIGRAGQCILAGNPHVLHVRVMAPTDVRISRVADEQKIPFEQARSLVERSDRSRMEYLRRFYHANIDDPTLYDMVLNTSRISVRCAALLIEALIKNHENHENHEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N606</accession>
    <name>E8N606_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18440"/>
    <dbReference type="EnsemblBacteria" id="BAJ63870">
        <property type="protein sequence ID" value="BAJ63870"/>
        <property type="gene ID" value="ANT_18440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18440"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136788_1_0_0"/>
    <dbReference type="OMA" id="DPYNKYR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="87" mass="9630" checksum="9AF4EA2318EF6671" modified="2011-04-05" version="1">MIPIFITLIRSVAQILSVLIIIDAVLSFFLSPFHPVRETLGKVLNPLYAPIRRVLPPMGGIDFSPLILIILIQVIERLLISLISSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N622</accession>
    <name>E8N622_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560263.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18600"/>
    <dbReference type="EnsemblBacteria" id="BAJ63886">
        <property type="protein sequence ID" value="BAJ63886"/>
        <property type="gene ID" value="ANT_18600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18600"/>
    <dbReference type="eggNOG" id="COG3191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044458_1_0_0"/>
    <dbReference type="OMA" id="PHFWAAP"/>
    <dbReference type="OrthoDB" id="2000083at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="336" mass="33956" checksum="C29041C80A8121AA" modified="2011-04-05" version="1">MDTYPGSITDVPGILVGHAQNAEALTGCSVVICEQGATGGVDQRGGAPGTRETDALRPMHLVEKIHAVVLSGGSAFGLSAASGAMRWLAEKGIGFPTGVVPVPIVASAILFDLGIGDPTIYPDEAMGYHACQQAVSAPPTQGNAGAGTGATAGKILGMSQAMKSGIGTASMYLSGGIVIGALVAVNPLGDVIDPESGKILCGARTLKKGPVQIGKSSVFADTLAVMNSLAGRSILHFAARQNTVIGVVATNAKLSKEQANYVAMMAQDGLAMSIRPAHTLLDGDTLFVMATGEKRADPNIIGAYSAQVVARAIVNAVLYAQPVGGIPCAGDYLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N638</accession>
    <name>E8N638_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_18760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560279.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18760"/>
    <dbReference type="EnsemblBacteria" id="BAJ63902">
        <property type="protein sequence ID" value="BAJ63902"/>
        <property type="gene ID" value="ANT_18760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18760"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="NICKFYS"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="247" mass="27584" checksum="4D3BA6716ABE6833" modified="2011-04-05" version="1">MESVEQPMIAEFPESLQNREMIVKVSHVTRIYELGASRVTALRDISLEIPKGVLVALKGRSGSGKTTLLNMIGGLDTPTQGEVELFGIRLSQLDDEAKTELRRQRLGFVFQSFAILPVFSAIENVELMLRIANIQTDRRKLAMRALEIVGLGSWAHHRPWELSGGQQQRVAIARALATRPELIIADEPTGELDSTTGRQIMALFRFIAVKEGITVLMATHDPLIEEYAHMVVDLMDGQIRSIRFPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N667</accession>
    <name>E8N667_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutY</name>
        <name evidence="15" type="ordered locus">ANT_19050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560307.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63931">
        <property type="protein sequence ID" value="BAJ63931"/>
        <property type="gene ID" value="ANT_19050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19050"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_0_0_0"/>
    <dbReference type="OMA" id="RDPYRVW"/>
    <dbReference type="OrthoDB" id="1274533at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005760">
        <property type="entry name" value="A/G_AdeGlyc_MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01084">
        <property type="entry name" value="mutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="14">
        <location>
            <begin position="228"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ63931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="364" mass="41531" checksum="C4A39CB9BF6612BA" modified="2011-04-05" version="1">MFTQISRQLLDWYQIHARNLPWRKEESAPYAVLVSEIMLQQTRVETVIPYYQRWMERFPTLESLAQASLEEVLRYWEGLGYYSRAKNLHRTAQILVQTYRGEFPQHVEHLRKLPGIGDYTAAAIASIAFGQKVAAIDGNVRRVLSRLFLISEPLSLPETQKKLKSLAVQCLPAEQVGDYNQALMDLGALICLPRSPKCLQCPLSVLCRAYQNNQQNDIPVKAKKKSLPSVIVTAAIIRKGDTVLLAKRPLGSLLGGLWEFPGGKVEHDERLPECLKREILEELGVRIEVGNHFGTYHHAYTHFKVTLHAFEAIIQDSQIPHPIEAEEIRWIPIPSLDKFPMGKIDRLIARELVERKDGHGKFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N673</accession>
    <name>E8N673_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63937">
        <property type="protein sequence ID" value="BAJ63937"/>
        <property type="gene ID" value="ANT_19110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19110"/>
    <dbReference type="HOGENOM" id="CLU_2803068_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="67" mass="7779" checksum="D799EDF0AF43D134" modified="2011-04-05" version="1">MNCASTLNLTSEWERFKIALERSLQMKQKQGKNRVQHEQSIRRRNQIILLGLSLIIILSMIISLVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B8</accession>
    <name>E8N6B8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_19560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19560"/>
    <dbReference type="EnsemblBacteria" id="BAJ63982">
        <property type="protein sequence ID" value="BAJ63982"/>
        <property type="gene ID" value="ANT_19560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19560"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_3_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="37095" checksum="43B7BFDE6B545477" modified="2011-04-05" version="1">MSVRVTEHSCSLKRCFPLIAKGGTFILVVYFCFWEIDWKPVFHILASVDWKWGTLSVLSFFFTLGMKILRWGVLLRLVGGERDMVASQDLIAPFFVGQAVNIVMPFRGGEVLRLSWLGVKDKRLMLPGAFSILLEKWEDLLFLSLLTLVLAPWVSEWIKFPPVYSWFLAGLVLLILGGVVWAIRFFNLQSISFIPQPFREVLGPEIGRLQQRLNLTKRHLFLVFLSVFLSMLIWGSMILTNLFTLQALALPVNVKIAGVILVFVYVSLIPALIPGNVGPFHGAVVLGMSLFQIPLAPSLSFAILLHGIVTVFPLVVSALILFWGRWKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C2</accession>
    <name>E8N6C2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_19600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560359.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19600"/>
    <dbReference type="REBASE" id="32156">
        <property type="entry name" value="M.AthUNI1ORF19600P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63986">
        <property type="protein sequence ID" value="BAJ63986"/>
        <property type="gene ID" value="ANT_19600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19600"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_5_1_0"/>
    <dbReference type="OMA" id="WRKANPM"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="368" mass="42691" checksum="09F946897FB10191" modified="2011-04-05" version="1">MDEFDPTLPLNQILQGDCRQILPSLPDQSIDLIFADPPYNLQLQQDLYRPDRSRVDAVNDSWDQFTSFAEYDEFSRSWLTECRRVLKDDGAIWVIGTYHNIFRLGTILQDLGFWILNDVVWIKSNPMPNFRGVRFTNAHETLIWAVKSRRANYTFNHHAMKALNEDLQMRSDWYIPICSGTERIRIHGKKVHSTQKPEALLYRIILATTRPGDVILDPFFGTGTTGAVARRLGRNWIGIEKEPRYIELARQRIEQIEPYPQQALALPVRSRKSRLPFGRLVEQNLVQPGQILFFDRNPEIRAVVLSDGHLSVNGWKGSIHMTAEKICGHPTNGWERWFFLDEQGIFQPISILRQKYLSNVSIENDMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C5</accession>
    <name>E8N6C5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560362.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19630"/>
    <dbReference type="EnsemblBacteria" id="BAJ63989">
        <property type="protein sequence ID" value="BAJ63989"/>
        <property type="gene ID" value="ANT_19630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19630"/>
    <dbReference type="HOGENOM" id="CLU_1243210_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="24801" checksum="561B8BB360019B77" modified="2011-04-05" version="1">MSEGFPAQIEERIKRLLGELEIPPPVPERSPIVESTSAVYLPQEIVRTYYPALDLYIHAELPKTSTLPAISIPFSLNTHQNGKITLYKTDKPLHEIEKGFIESILEALVSHLNALSKELRRSTSSLTEKLNAHPKHQGSDIQEKRLALWNGEFVPFLSQAKISAEKNLATLKAGDGTLGSFNITLHGSPVTEQHHEFLIDILDALSKQIIQLGYQQATQKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG6</accession>
    <name>E8MXG6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PS_pyruv_trans domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64047">
        <property type="protein sequence ID" value="BAJ64047"/>
        <property type="gene ID" value="ANT_20210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20210"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_614874_0_0_0"/>
    <dbReference type="OMA" id="PVICIAY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="54"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="420" mass="47426" checksum="FF619AE6A3F8171A" modified="2011-04-05" version="1">MSFSHTAGSFLDKGYMKQFLLSIFLKLYAQWAGATGKPYPNSVLLLPPYSPGSYGDAAVVTSFVENLASRGIERIGLIKYQDSDDWSSVNGIRETFSLEDYFHYEAWKIRFSFCKKISEYEQFFILGTDVMDGYYSPKDSLERIYLTELGAQTGRPTRIVSFSFNAHPIPACVTALRHLSPSVHLFSRDPVSQKRLESHLQRPVTLTADIAFLLRPREGNISAGIEQWIDEQQKDNGIVVGINANHVLVEKFSEITIEKLVKAYQEALQEIHAAYPDIRFLFIPHDIRGDASDVVIAEAIFRTLPPNLQQVSKIVPSPCHPAEIKHIVSRLSFVLSGKMHLAIACLSQGVPVACIAYQDKFEGLFQHFEMEDMSLAPEELLLPGKLSQFFLKRFNKKENLSAQIQTHLPRVLQLAEKNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI0</accession>
    <name>E8MXI0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_20350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560431.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20350"/>
    <dbReference type="EnsemblBacteria" id="BAJ64061">
        <property type="protein sequence ID" value="BAJ64061"/>
        <property type="gene ID" value="ANT_20350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20350"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640378_0_0_0"/>
    <dbReference type="OMA" id="TGMLTYH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="74"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="48945" checksum="C72443910C9816E5" modified="2011-04-05" version="1">MRRSPLFWICTLAVILRVGVAVYLGNTVEALPGVSDQLSYHHLAIRVVEGHGFSFDRAWWPATRAGEPTAHWSFLYTFYLAGIYALFGVHPVFARILQAILVGILQPWLSYWVGKQIFGHKVGVWAAFLNAIYLYFIYYSGTLMTEPFYITAILGVLALTIQLTQSAKTSLQQTRTAILLGLVYGIAVLLRQLFLLFLPFLILWIFIKNQQEKIGLQWWHGVISLGVILVMILPFTLYNYQRFGEFVLLNTNSGYAFYWANHPYYGTKFIPILSEEEYLNLLPEELLSLNEAALDKALLSRGIQFVLDDPVRYGMLSLSRIPPYFDFLPRSESGWISNITRVFSFGVFFPFMLVGLFLAIKDTFKTIPTFFSSPPALLILFSIVYIGIHVLTWTLVRYRLPVDAVWLIFAGLTFVRISARMFHPVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI1</accession>
    <name>E8MXI1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560432.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20360"/>
    <dbReference type="EnsemblBacteria" id="BAJ64062">
        <property type="protein sequence ID" value="BAJ64062"/>
        <property type="gene ID" value="ANT_20360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20360"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028014_3_0_0"/>
    <dbReference type="OMA" id="FSGKMSY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="405" mass="45793" checksum="153D646A3EA67CCE" modified="2011-04-05" version="1">MNILYYVPYPPNLIRVRPYNLIRALLERGHSITLASLITSAADGEDLHRLEAMGVQIVSASMPKWRSLVNCIVYLPTRHPMQAVYSWNASLANRLRGLIKKTQFDIVHVEHLRGAKVGLSLINGANPPVVWDSVDNISHLFRQAAQKATTLSSKAITYFELLRTPSYERWLCEQFDQTLVTSPVDRQAFLHLNPRYPERLSVLPNGVDLRFFTPGTPEQRQDNEIVVSGKMSYHANISMVMHLAHNIMPLIWSQRPDVRLTIVGKDPPKSIKELSQDSRITVTGEVPDIRPYLQRATIAVAPITYGAGIQNKVLEAMACATPVIASPQAVQALNCTNGEDLLIAEAPQIFAEKVLLLMQDRIMRETLGQNGRRYIEHHHSWNAMAKKLEEIYQRVLNFREIGRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ0</accession>
    <name>E8MXJ0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20450"/>
    <dbReference type="EnsemblBacteria" id="BAJ64071">
        <property type="protein sequence ID" value="BAJ64071"/>
        <property type="gene ID" value="ANT_20450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20450"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212770_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="228" mass="25875" checksum="ACCD18C071527D70" modified="2011-04-05" version="1">MNDRLYHTLRLLAAPFRYSCSDAGCPSPGQPAIFVANHCGPIGPIQSILSLPRRVYPWIVVDMLDSQKIVPYLYKDFVTTSLHLKGKPGWFLAKVIARMALPFLNSLGCIPVDRYDVRFSGAFLRSLELLERGEALLIFPEDPLLPIKPQTGMRPFMSGFLWLCVLYKRKTGSRLPVIPTAVIPAERKIYLGEPMYYREAQFPKEDTRKMAQEVEKKISQLLAESPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP6</accession>
    <name>E8MXP6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sodA</name>
        <name evidence="9" type="ordered locus">ANT_21010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560497.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21010"/>
    <dbReference type="EnsemblBacteria" id="BAJ64127">
        <property type="protein sequence ID" value="BAJ64127"/>
        <property type="gene ID" value="ANT_21010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21010"/>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_0"/>
    <dbReference type="OMA" id="KWGSFDK"/>
    <dbReference type="OrthoDB" id="1440645at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="202" mass="23291" checksum="F11176C74FF72A74" modified="2011-04-05" version="1">MAFELPPLPYAYDALEPYIDARTVELHYSKHHMTYLNNLNTALEKAPQFFEWPLEKILSHLDEIPEEIRMTVRNNGGGVFNHNIYWAIMGPNRGGEPVGNLARAIEKTFGSFASFKEQLEKAGLGRFGSGWAWLSKKADGTLVIHSTPNQDTPLAEGLYPIIGVDVWEHAYYLKYQNRRAEYLSNWWNLVNWEEAEKRYNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU1</accession>
    <name>E8MXU1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T2SP_E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560542.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64172">
        <property type="protein sequence ID" value="BAJ64172"/>
        <property type="gene ID" value="ANT_21460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21460"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672027_0_0_0"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="87"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="409" mass="44460" checksum="A26C418AC8CCA1D2" modified="2011-04-05" version="1">MSWLELMAQVTPQQEAQIVEMAAKELQGLPLAVLRDRQQLQARAQAAVSSAATRVGVALQPNLQAALAKAVAGRIGGLGALDELLPPTRTDLSEISLNPDGTIWILRKGERYFEKHNRQPSLDETWRSVEALLAPIGRAISEAQPSVDAKLPRMEGMGGARVKIVHPVLAPGLGYPAINIRLFEPRPVPPEQIVAWGMCPQAVMETLLDGVAQGLRVLVIGGTATGKTTFLSALAHGIPRTARIVKIEDPEEIWLPHENVVTLEARPQVVGSDVPGYSLSDGVDDAMRMAPNWLIVGEVRTGTAALSLFRAQMSDHPGLSTLHAEGPEAAIHRLGVLMWADAQVRIEAAKEMFAMAVDMVVQVGWREGKRQVLGVWEVNPELKGGNVTFRRLYQAGEERMEAFTRRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU3</accession>
    <name>E8MXU3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_21480</name>
        <name evidence="5" type="ordered locus">ANT_24130</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="4">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560544.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21480"/>
    <dbReference type="EnsemblBacteria" id="BAJ64174">
        <property type="protein sequence ID" value="BAJ64174"/>
        <property type="gene ID" value="ANT_21480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64439">
        <property type="protein sequence ID" value="BAJ64439"/>
        <property type="gene ID" value="ANT_24130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21480"/>
    <dbReference type="KEGG" id="atm:ANT_24130"/>
    <dbReference type="eggNOG" id="COG3745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958589_0_0_0"/>
    <dbReference type="OrthoDB" id="2060643at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008953648" description="SAF domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="29321" checksum="56612A4BBFD14E40" modified="2011-04-05" version="1">MKKFIPLVLAIVVFAVALALNQPEPQVSVVVAAGDLPEGRVLTEGDLTAKELPKSLAPEGAVSDPQSLVGQRLRVARSAGDPVLPVHLGGETLELRPNERAVALSVTAAQGLAGLLKPGDRVGVTVIVNASQQTFAKYIAGGLRVLWIDPAFRREEAPAPQGTPAAGGGLFGGGSSTGGAVDTGGTAKGLVVLAVPVEAKSVVYDFSLLGAMNETLPVYLVDLLPALSAQGAQFGLVLEPEKANGEVITSGLSLQGIAVTPGATLTPTPTGAAPAQDAEAVSTPEPTKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY74</accession>
    <name>E8MY74_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome d ubiquinol oxidase subunit 1</fullName>
            <ecNumber evidence="13">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cydA</name>
        <name evidence="13" type="ordered locus">ANT_22790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="13"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560672.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64305">
        <property type="protein sequence ID" value="BAJ64305"/>
        <property type="gene ID" value="ANT_22790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22790"/>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_3_0"/>
    <dbReference type="OMA" id="WAIIFNP"/>
    <dbReference type="OrthoDB" id="271551at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ64305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="456" mass="51378" checksum="97B55CE7A8ECAEF7" modified="2011-04-05" version="1">MSVLTLSQWQFAITSVYHFFFVPLTLGLSVLTAIMETIYVRSGQEVYKRMAKFWGTLFVINFAMGVVTGIVQEFQFGMNWSEYSRFVGDIFGAPLAIEALLAFFLESTFLGLWLFGWNKLSKGLHAFTMWMVALGSNISALWILIANSFMQHPVGYTLEGGRAVMTNFGALLTNPYVWTQFPHTVLSGFTTAAFFVAGISAYHLFRKNEEDLFRRSFNLAAVFGMISIFLVILVGHSQAQRMVQVQPMKMAAVEALWETENPASFSLFTIGDEKNLKDRFALRIPYLLSILAYNQPTGEVKGIRNLQAEYEQLYGPGYYVPSVFTAYWTFRIMVGSGFLMFALMAVALWFVLKNKPLAGTRFGKWLPFAIALPYLANSTGWILTEMGRQPWVVYGVMKTEQAFSPNLTPGMVLTTLILFTIVYGVLMAADIYLLAKYARKVPAEGEEQALQEAYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY77</accession>
    <name>E8MY77_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22820"/>
    <dbReference type="EnsemblBacteria" id="BAJ64308">
        <property type="protein sequence ID" value="BAJ64308"/>
        <property type="gene ID" value="ANT_22820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22820"/>
    <dbReference type="eggNOG" id="ENOG5033NM4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166864_0_0_0"/>
    <dbReference type="OMA" id="WHIPARR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="113" mass="12792" checksum="A90B71C0CAAAFE90" modified="2011-04-05" version="1">MMNSKMVTRILLSMAVLITAVIHLYLGMVYDAFIFILNGIGFLGLWGLFLLPMAFLRPYRRWVGFVLMGYSAITILLWAVLNGELDVASISAKLAELVIIVTVWLDLQRVEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY98</accession>
    <name>E8MY98_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_00090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558441.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62043">
        <property type="protein sequence ID" value="BAJ62043"/>
        <property type="gene ID" value="ANT_00090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00090"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_0"/>
    <dbReference type="OMA" id="HCPISSV"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="82"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="36003" checksum="E52E974019919983" modified="2011-04-05" version="1">MSQSMQPNEGSKTRRESKEAVLTAQARSAQDAHVNPLAVALFIVFITLAVVLAAVLEARGAGDIAIVTAVLLPTLIGVYILFAFRMARQWEKAVVLRLGRFHSLRGPGVFWMLPVIDSIATWIDHRVMVTPFSAEKTLTKDTVPVDVDAVLFWVVWDAEKAALEVEDYRAAITWAAQTALREVIGQMPLADILVGRAKMDADLQKIIDERTTPWGVTVQSVEIRDIIIPQALEDAMSRQAQAERERQARVILGESEKQIAESFAEASRAYQNNPTALHLRAMNMLFEGLKEKGALVIVPSSAVDTMNLGGLSGVVALGQQHLPKEGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA2</accession>
    <name>E8MYA2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00130"/>
    <dbReference type="EnsemblBacteria" id="BAJ62047">
        <property type="protein sequence ID" value="BAJ62047"/>
        <property type="gene ID" value="ANT_00130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00130"/>
    <dbReference type="HOGENOM" id="CLU_3211695_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="44" mass="4998" checksum="0C2DA48DB7841222" modified="2011-04-05" version="1">MIKGVYVQTKGTLQWYVPARTIRHPLSLLVTTARPETAERRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ3</accession>
    <name>E8MYJ3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M23 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_23030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23030"/>
    <dbReference type="EnsemblBacteria" id="BAJ64329">
        <property type="protein sequence ID" value="BAJ64329"/>
        <property type="gene ID" value="ANT_23030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23030"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749334_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225322" evidence="2">
        <location>
            <begin position="29"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="135"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="369" mass="41571" checksum="5AA36087AEA7D4AC" modified="2011-04-05" version="1">MKAVTRKTYGFWILAMLTLLSACSTSLREIPQEMASDTALAMQETQHAEGTESQELVRSDDLSSDDADSEPVRFTFPTPLPPPKSAWRPPLYDVPWAPGPYDHFYFTRPIAADEVNWPVADYRYGGIFFSSDIVHTGVDIPAPRFTPVLAAGNGRVVWAGYGLYYGQNNPNDPYGLAVTIRHDFGWQGQRLYTVYAHMERLNVVNGQVVQQGDVIGWVGVTGLTTGPHLHFEVRTDRNSYFTTLNPELWLSPPIGWGVLVGQLRNTNGSLLTEQDVIVRSWKTNQKWTVRSYGKSAVNSDPYYKENLVLSDLPAGDYEIIIDYLGKRFTRNMTIRPGQVTYFTFRGEDGFQSEELPVPDIEDILEAFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYT0</accession>
    <name>E8MYT0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560782.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64416">
        <property type="protein sequence ID" value="BAJ64416"/>
        <property type="gene ID" value="ANT_23900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23900"/>
    <dbReference type="HOGENOM" id="CLU_1891827_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="15365" checksum="BEB4F3F3F1B15C21" modified="2011-04-05" version="1">MKIKGFRLSDETQTQIAWLAKRKGVTATDIVRMAVAEMFQQEIARLPRFRLREQVLYLNDQPVVFCTDRLLTELPETFLLQLEHGTADPMETMIYLIFTIARIGEPVQIDEQALNDLIGWSLPSLKGDQDEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYU4</accession>
    <name>E8MYU4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetylmuramoyl-L-alanine amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24040"/>
    <dbReference type="EnsemblBacteria" id="BAJ64430">
        <property type="protein sequence ID" value="BAJ64430"/>
        <property type="gene ID" value="ANT_24040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24040"/>
    <dbReference type="eggNOG" id="COG3023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083537_0_0_0"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="28253" checksum="5FFF30D9BCF4830C" modified="2011-04-05" version="1">MQVEIVSPVKFVTFLAGLILLVGGVWGLVHVPQGAAAAQALPSPTPTPLLTAAVFEPTATPMAVPTATPMPTPTAVPDNLQTYLEGCRKGGAAAFTPDYAGAVVAASCNHGGENRPQAVVVHATEGELPAALAHLRDPQSRVSAHYVVDRDGTVYQLVPERAVAYHVACGVEGCVSSCPAFLCGDGRPESRSIGIELVNRGKVPQDWRGAVYEDYGMAFGWRWLTRACTWRRGWGRLECTCCGGWCAANAACRAMWAFWWGWWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY4</accession>
    <name>E8MYY4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64470">
        <property type="protein sequence ID" value="BAJ64470"/>
        <property type="gene ID" value="ANT_24440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24440"/>
    <dbReference type="HOGENOM" id="CLU_1682994_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="19739" checksum="B480969EE1600B95" modified="2011-04-05" version="1">MRPALEVTRITKVQDERIDMLTLPTFIPLSEAARKYGLEEDRLRALVEKGKIRAGVVAGEMVVSEEEVRGEAIQEKGLRKEDLPEYQKHAEKRGRPIWILKAAEKYRVPFSTLRGWVAKGYIKVIGNEGKKVLLDEQDVAYCAEIYDQRRGQGKWLFDDNGLPYKPKTGPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY7</accession>
    <name>E8MYY7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558528.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00960"/>
    <dbReference type="EnsemblBacteria" id="BAJ62130">
        <property type="protein sequence ID" value="BAJ62130"/>
        <property type="gene ID" value="ANT_00960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00960"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="OMA" id="DTTACIP"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="31490" checksum="DE57FBFA5CD557BC" modified="2011-04-05" version="1">MNTTPIALITDSTCDIPPAYLEQYGIIVQPHVLIWNGVEYRDRVTLSSEEFYRRIQSEGTLPTTAQASVHDFLSLFHSLQEQGYREVVVILLSGHFSGAMLSAQQAAQQSPIPVHVYDSRAVTAGLAWQVLAAARARERGASAQEMLAAADEVRRKVRLVIALDTLEYLHRGGRIGKAAWLAGSILQIKPLIRVNHETGIVEAYGVERTRQRVIEAMIKRFFKEVAGEGRLHVAVMHGMAEEEAQAIAARIRQEHPNAEVYVHLTGPILGLNTGPRALALGGYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ46</accession>
    <name>E8MZ46_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558587.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01550"/>
    <dbReference type="EnsemblBacteria" id="BAJ62189">
        <property type="protein sequence ID" value="BAJ62189"/>
        <property type="gene ID" value="ANT_01550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01550"/>
    <dbReference type="HOGENOM" id="CLU_2598378_0_0_0"/>
    <dbReference type="OrthoDB" id="2060071at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="79" mass="8897" checksum="09A22EF0F1EA5529" modified="2011-04-05" version="1">MMRTGMLWYDGDAHADLQTKVQRAAAYYQKKYGIMPTLCFVHPSMLPEEPVRSGVIELRPSKQVLPNHLWLGVPEGGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA8</accession>
    <name>E8MZA8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62251">
        <property type="protein sequence ID" value="BAJ62251"/>
        <property type="gene ID" value="ANT_02170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02170"/>
    <dbReference type="HOGENOM" id="CLU_2875864_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="63" mass="7135" checksum="4AB3E8FF0FE1A57A" modified="2011-04-05" version="1">MTSDEIVMFLGFLVFLLYPAIAIYVALQKKRTCFALGIFLSIFIGLGPFVSTYFFLASTKNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF4</accession>
    <name>E8MZF4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560857.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64502">
        <property type="protein sequence ID" value="BAJ64502"/>
        <property type="gene ID" value="ANT_24760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24760"/>
    <dbReference type="eggNOG" id="ENOG5033HTI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1502809_0_0_0"/>
    <dbReference type="OMA" id="GTAWLYP"/>
    <dbReference type="OrthoDB" id="1738709at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021776">
        <property type="entry name" value="ActD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11821">
        <property type="entry name" value="DUF3341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19695" checksum="0D91FE64ED3F469B" modified="2011-04-05" version="1">MPREVVHLALFKEEQLNEAVEAIQALREMGISDRNISVISGAPLQERMLGRPMTWTRIPLIGISGAVVGLLTALFFNFGTPLLYPIRVGGMALQTIPTSFVTIFELTMLGLLISTFLGVFVETISPSYGPQGYDERISDGYIGVLFSAPAELDARMHEMLTGLGAEIVHRAEAKKLWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS7</accession>
    <name>E8MZS7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25990"/>
    <dbReference type="EnsemblBacteria" id="BAJ64625">
        <property type="protein sequence ID" value="BAJ64625"/>
        <property type="gene ID" value="ANT_25990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25990"/>
    <dbReference type="eggNOG" id="COG4842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1431856_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="189" mass="21847" checksum="1AF5E876609D7DB4" modified="2011-04-05" version="1">MGEAVPSHAHRNNPKTTRRTQFNLPITSSTFIIRQMKGKTFPYSKQQLKHLLHKITGSLCIAFTTTKFLQFVYNSRKDIYLYYNVLYNFFKLFQGGLYMTTLHMEVETARSTASNMANTYQQLIGLVQSMNSSVNNLQSAWMGNSATEFFGLYDQWRSSMNTILENLNTMTTKLQTEITEWEQMASNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT3</accession>
    <name>E8MZT3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_02340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02340"/>
    <dbReference type="EnsemblBacteria" id="BAJ62268">
        <property type="protein sequence ID" value="BAJ62268"/>
        <property type="gene ID" value="ANT_02340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02340"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089201_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="26"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="32902" checksum="124CDE1985AE3C77" modified="2011-04-05" version="1">METVLLPSTQSKSLSRTTWAAQLRALGAIIWREYLHFVRYPTWIIAFIIWPILFPATYIFSSFALAGPGGSGVARFLEVAGTENFLGYIVVGTTVWMWANTMLWNVGFALRGEQMRGTLESNWMTPTNRFFFLLGSGPVHAASTLMFFIFTVVEFRLFFHLTFDANLLSLLAVFLAALPALYGLGFTFASLVITAREANTFVFLVRGIVMIFCGITYPLTVMPQWMQAVAEWLPPTLIIRAARLAALNHAPLEAVSRDLLLLLAYGAFWLALGYLTFSQIERRARLKGALNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU8</accession>
    <name>E8MZU8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nickel-containing superoxide dismutase</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558680.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02490"/>
    <dbReference type="EnsemblBacteria" id="BAJ62283">
        <property type="protein sequence ID" value="BAJ62283"/>
        <property type="gene ID" value="ANT_02490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02490"/>
    <dbReference type="eggNOG" id="ENOG502ZR3M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141681_0_0_0"/>
    <dbReference type="OMA" id="AHCDGPC"/>
    <dbReference type="OrthoDB" id="1789560at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036502">
        <property type="entry name" value="NiSOD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014123">
        <property type="entry name" value="Superoxide_dismutase_Ni-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09055">
        <property type="entry name" value="Sod_Ni"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109770">
        <property type="entry name" value="SSF109770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02753">
        <property type="entry name" value="sodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="166" mass="19303" checksum="88F0AD5063B6AEE3" modified="2011-04-05" version="1">MLYQLLNQWDETFGLDEARAHCDIPCGIYDPHLAQMAALTVIRMVDLMEDLVKGEIKETMTFHNSLTRYILIKEEHAELCKREIRVIFGDFIKKEHVEKYPELPTLFHKIMQAGSKARQSASREAGLELLALVNRFAEIFWEIKGIPTKRVKAPYKPEEEIVYPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N024</accession>
    <name>E8N024_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">ilvD</name>
        <name evidence="16" type="ordered locus">ANT_03250</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558756.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62359">
        <property type="protein sequence ID" value="BAJ62359"/>
        <property type="gene ID" value="ANT_03250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03250"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_0"/>
    <dbReference type="OMA" id="TQGRNMA"/>
    <dbReference type="OrthoDB" id="193579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAJ62359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="555" mass="59366" checksum="AD03CD083FA1D05C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N033</accession>
    <name>E8N033_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">leuB</name>
        <name evidence="16" type="ordered locus">ANT_03340</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558765.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03340"/>
    <dbReference type="EnsemblBacteria" id="BAJ62368">
        <property type="protein sequence ID" value="BAJ62368"/>
        <property type="gene ID" value="ANT_03340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03340"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_0"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAJ62368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="354" mass="38069" checksum="1472D7FBB05C5ED8" modified="2011-04-05" version="1">MHKHIVLLPGDGIGPEVVSAAKRILDAVAGRLNLTLTYEEHLIGGCAMDAQGTALSQDTLHACQRADAVLLGAVGGPKWDDPAAPVRPEQGLLALRKGLGVFANLRPVRVYPTLVDASPLRAEKLQGVDLLVVRELTGGLYFGQPKGRFEENGRVRAVDTLEYWDYEIERILDLSFQLAQSRRGKLTLVDKANVLESSRLWRQIATDMASRYPQVTLETVLVDTAAMRLVSQPAAFDVIVTENMFGDILTDEAAVLSGSMGLLPSASLGKATPGLYEPIHGSAPDIAGQGIANPLGTILSVAMMLRYSFQLEQGARAVEQAVERALAEGCRTRDLGGSLTTAEMTDAVLQRLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N047</accession>
    <name>E8N047_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62382">
        <property type="protein sequence ID" value="BAJ62382"/>
        <property type="gene ID" value="ANT_03480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03480"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_1_2_0"/>
    <dbReference type="OMA" id="NGRDAPY"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="92" mass="10011" checksum="5EEB18FE38AB01F8" modified="2011-04-05" version="1">MVINLYATFRLLAGTKQIHLNLPENSTVRQALEDALRIVPALRPHWMNESGELHAHVHVLVNGQDVATLPEGLETPLQTSAVLDVFPPVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N070</accession>
    <name>E8N070_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methanethiol S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.334</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_03710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methylation of methanethiol (MeSH) to yield dimethylsulphide (DMS).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:50428"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:17437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.334"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nurim family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.334" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558802.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03710"/>
    <dbReference type="EnsemblBacteria" id="BAJ62405">
        <property type="protein sequence ID" value="BAJ62405"/>
        <property type="gene ID" value="ANT_03710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03710"/>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084189_1_0_0"/>
    <dbReference type="OMA" id="YVRHPYY"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033580">
        <property type="entry name" value="Nurim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040">
        <property type="entry name" value="PTHR31040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="215" mass="24423" checksum="D5A9D8FE9CA0828F" modified="2011-04-05" version="1">MDIPSGFWLTLLACAGYGAIHSALASHTVKGWAERRFGQFARRTYRLFFVLMASLTTLALLAVPLLLPDRPLYVIPFPWIILTLAVQAFAVWGLLAALSQTDALAFLGLRQLSAPEPLRRRAKSGELVTRGFYGRVRHPLYLFSLILLWLFPVVTWNILALMIGLTVYLYIGTLLEERKLLDEFGEAYAEYRRTTPMIFPRLLPGRVTRPRQEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0D5</accession>
    <name>E8N0D5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64684">
        <property type="protein sequence ID" value="BAJ64684"/>
        <property type="gene ID" value="ANT_26580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26580"/>
    <dbReference type="eggNOG" id="COG3462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159099_3_1_0"/>
    <dbReference type="OMA" id="GWIGMIL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="82" mass="9069" checksum="A415CFC26FAA8E81" modified="2011-04-05" version="1">MMFCGFGNFGGFGWIGMILNLVITIGLLVGLILLVVWAVRRLSESGVQSTSSQTARDIAQARYARGEISREEYQQIISDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E0</accession>
    <name>E8N0E0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561041.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64689">
        <property type="protein sequence ID" value="BAJ64689"/>
        <property type="gene ID" value="ANT_26630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26630"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_0"/>
    <dbReference type="OMA" id="RAWNDRS"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="327" mass="36760" checksum="5B7930EC76CF1A9A" modified="2011-04-05" version="1">MEYRPLGRTGWKVSAISFGAWAIGGTWGPVQDEESIAALHRAIDMGVNFIDTADVYGDGRSERLIAQVKKSRKEEIIVATKAGRRLNPHTAEGYNRQNLTTFVERSLKNLEVEALDLLQLHCPPTPVYYMPEVFGILDNLVAAGKIRYYGVSVEKVEEALKAIEYPNVQSVQIIFNVFRMRPAELFFREAARRQVGIIARVPLASGLLTGKITRETQFSPDDHRAFNRQGEAFDRGETFSGVDLDIALQAVEELRPLVPPGMTMTQFALRWILMFPEVTCAIPGAKRPSQAEENFSAADLPPLSEETMQKVKAIYDARIKPLVHHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F9</accession>
    <name>E8N0F9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561060.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26820"/>
    <dbReference type="EnsemblBacteria" id="BAJ64708">
        <property type="protein sequence ID" value="BAJ64708"/>
        <property type="gene ID" value="ANT_26820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26820"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_10_4_0"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="71" mass="8240" checksum="643C77055FA2DD5C" modified="2011-04-05" version="1">MAKQRFSVPDMHCSACVMRLESLEDELPGVKQVKASYHKQEMEVEYDESKLTLEDLLEAVQKKGYHPQPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H3</accession>
    <name>E8N0H3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561074.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26960"/>
    <dbReference type="EnsemblBacteria" id="BAJ64722">
        <property type="protein sequence ID" value="BAJ64722"/>
        <property type="gene ID" value="ANT_26960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26960"/>
    <dbReference type="eggNOG" id="ENOG5033AYZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905026_0_0_0"/>
    <dbReference type="OrthoDB" id="1559915at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228580" evidence="3">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="34188" checksum="A64A5375F51EE09F" modified="2011-04-05" version="1">MRRRLYLLLTLLLLVISAFPVQAQAQEIRFQNVEVLVWPEYDRERSVLVIYRITLGGDVKLPAEITLPMPAAAKTPHAVAEQNENGLFNVDYTLSSVQNNMIWVTFLATVPQIHLEYYDPTLEVSDTSRVYRFRYLMPYPTDNLVLEIQRPRTATALTLDPPGGTSQQGTDGLTYYGVVVGEVKANLPVNLKITYQKSDDELTQPNTFEPVAPAEAVSESTPGKLNFTEVIPWAVGALGLVMVIAAGWMFLQARKESEETPMKRHKPSRTAKPDSSGNEALYCPQCGKRAAPGDLFCRSCGTRLPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L8</accession>
    <name>E8N0L8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">valS</name>
        <name evidence="13" type="ordered locus">ANT_27410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561115.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27410"/>
    <dbReference type="EnsemblBacteria" id="BAJ64767">
        <property type="protein sequence ID" value="BAJ64767"/>
        <property type="gene ID" value="ANT_27410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27410"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_0"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
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            <dbReference type="Pfam" id="PF08264"/>
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            <dbReference type="Pfam" id="PF10458"/>
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            <dbReference type="Proteomes" id="UP000008922"/>
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    <sequence length="902" mass="103324" checksum="D8CE636C5E9422B9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0M1</accession>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="136"/>
        </location>
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        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="BAJ64770.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="10">Hypothetical membrane protein</fullName>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EnsemblBacteria" id="BAJ62421">
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008922">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RgtA/B/C-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        </location>
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            <end position="243"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ62421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="512" mass="57333" checksum="07561710B95C2E15" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0M7</accession>
    <name>E8N0M7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
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        <name evidence="8" type="ordered locus">ANT_03880</name>
    </gene>
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        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
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    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
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    <dbReference type="STRING" id="926569.ANT_03880"/>
    <dbReference type="EnsemblBacteria" id="BAJ62422">
        <property type="protein sequence ID" value="BAJ62422"/>
        <property type="gene ID" value="ANT_03880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03880"/>
    <dbReference type="eggNOG" id="COG5615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1559773_0_0_0"/>
    <dbReference type="OrthoDB" id="11838at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="7">
        <location>
            <begin position="55"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="18746" checksum="2AD57E78DB2081A0" modified="2011-04-05" version="1">MQASSLALALTYWLHMLATVLWLGSLSALAVLVLPAARRRLDASAYAALLEDLQERLQPLAWLSLAVLAATGMFQMSAHPRYSGFLAIENAWAVAILIKHLFVGGMVLLSAYNTWGLLPQLRRMAILRASGKPLDETQLAQIQRRERLLLTLLLISSVLVLAFTALARAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0M8</accession>
    <name>E8N0M8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_03890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03890"/>
    <dbReference type="EnsemblBacteria" id="BAJ62423">
        <property type="protein sequence ID" value="BAJ62423"/>
        <property type="gene ID" value="ANT_03890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03890"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682644_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="403" mass="44696" checksum="DDAC0F58F0FA1011" modified="2011-04-05" version="1">MSDSCGIMYPMSDMDLENTQPSRPREDMEDTQPHTPVSRGVSPVPPEQRAAENEPHTQPRRRSLRGWVIAGGIVLILLLGGLGAFLGYRAAQAARSQMSREQIVTLATEQMMLAQQDLEQGRFQIARKRLEYVIQLDPNFPGVQEKLAEVMIQEAFSLTPTATIALATSTPTPTPDFRGEEEIFNNARQLLAQKEWFAVLDMLDALRNKNLTYRAVEVDGMYYIALRNRGLAKINNGNLEGGLYDLALVERFGPLDVDAQGVRNWARLYLTGAAYWGVRWDQVIFYFSQIVPAYPGLRDVNGVTALERYRVALIKYGDQLAAEGKYCDALKQYEAAQQVAPDGMLEPTMTAVYNQCYVQPSETPTLPLTLTPTPTSTGVIVPPTETPTPPAAPSETPTETPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y0</accession>
    <name>E8N0Y0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558921.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04910"/>
    <dbReference type="EnsemblBacteria" id="BAJ62525">
        <property type="protein sequence ID" value="BAJ62525"/>
        <property type="gene ID" value="ANT_04910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04910"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114057_1_0_0"/>
    <dbReference type="OMA" id="CEVHIDG"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="14869" checksum="373900F68CB67179" modified="2011-04-05" version="1">MASARIKWTGQKEFIGVDSTNHSVVISTPAEGTGMKPSELLLVALASCTAVDVVEILTKKKLTLTGLEIFATAEQEADPPWTFRKIHLNYVFRGKDLTEKAVEQAIALSEEKYCSVAATIRGKAEITTSYEIHLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y2</accession>
    <name>E8N0Y2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">thrB</name>
        <name evidence="14" type="ordered locus">ANT_04930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558923.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04930"/>
    <dbReference type="EnsemblBacteria" id="BAJ62527">
        <property type="protein sequence ID" value="BAJ62527"/>
        <property type="gene ID" value="ANT_04930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04930"/>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_0_2_0"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="610857at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="202"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ62527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="299" mass="31626" checksum="F860F5DB41950566" modified="2011-04-05" version="1">MNFTVRVPATTANLGPGFDCLGLALDLWNEAEFCFEGEGICVEIHGEGAEALSKKPDNLILTAFFRLLHQLGAPKPRGVRLRVQNHVPVGSGLGSSASAVVAGLLAARAWSGRDIPAERLLDVAVSLEGHADNASAALFGGLTVSVNTPQGWLVERFEPAPMQMVVVLPQFSLSTRSARLALPALLEHGDAVFNLGRTALVVEALRRGDLELLGRVMDDRLHQPYRLPLIPGAQDALRAAKEAGAAAVALSGAGPSLIAFPYQDPEPVAHSMQTAFQKQGVPARAFYLHSTPLGAQILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y7</accession>
    <name>E8N0Y7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04980</name>
        <name evidence="3" type="ordered locus">ANT_19260</name>
        <name evidence="4" type="ordered locus">ANT_19860</name>
        <name evidence="5" type="ordered locus">ANT_30030</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="2">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558928.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04980"/>
    <dbReference type="EnsemblBacteria" id="BAJ62532">
        <property type="protein sequence ID" value="BAJ62532"/>
        <property type="gene ID" value="ANT_04980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63952">
        <property type="protein sequence ID" value="BAJ63952"/>
        <property type="gene ID" value="ANT_19260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64012">
        <property type="protein sequence ID" value="BAJ64012"/>
        <property type="gene ID" value="ANT_19860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65029">
        <property type="protein sequence ID" value="BAJ65029"/>
        <property type="gene ID" value="ANT_30030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04980"/>
    <dbReference type="KEGG" id="atm:ANT_19260"/>
    <dbReference type="KEGG" id="atm:ANT_19860"/>
    <dbReference type="KEGG" id="atm:ANT_30030"/>
    <dbReference type="eggNOG" id="COG3677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076276_1_4_0"/>
    <dbReference type="OMA" id="QHYKCHD"/>
    <dbReference type="OrthoDB" id="1853786at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ65029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="120" mass="13846" checksum="9E457227A87E2D18" modified="2011-04-05" version="1">MPTCPKCQQTERQNKAGRTESGAQRYKCMRCGHKYTPEPKPRGYPEEMRKQALQMYVDGMNLRRIARHLGVHHRTVSLWIQAYAARISEVPLPEEVKEVEMDELFTFIGHKKTGSTSSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N100</accession>
    <name>E8N100_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558941.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62545">
        <property type="protein sequence ID" value="BAJ62545"/>
        <property type="gene ID" value="ANT_05110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05110"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_1_1_0"/>
    <dbReference type="OMA" id="CTDTGLC"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="28152" checksum="449C2F2BCF8F94CD" modified="2011-04-05" version="1">MSQIQVTLLGTNGWFDTHTGNTPSVLVQAPDFDVILDAGYGFAKLDRFIRGDRPAFCFLSHFHLDHLIGLHTLAKYQFQHGLTIIGQPGTKWALDSLLSPVYSVPLTGLRYPVHIVETQPGWIEGLPFEAQALPLIHSQPCFGYRLQIAGKTLAYCTDTGYCENAVKLARQADLLLTECSQAPGTPHNDEWPHLSPTEAARIAREAEARQLVLIHFDPTQYPSLEDRIHAETEARKVFSSVTAGRDEMQFTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N188</accession>
    <name>E8N188_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_28050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561178.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64831">
        <property type="protein sequence ID" value="BAJ64831"/>
        <property type="gene ID" value="ANT_28050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28050"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038661_0_0_0"/>
    <dbReference type="OMA" id="PMVVDMT"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="418" mass="45768" checksum="62AF6D70B794B9FD" modified="2011-04-05" version="1">MKFSIGRTFLLGFGFFGVSVIWMVYNAFVPLFLANRFHIEPWLIGLFMTFDNFAALFIQPPVGAWSDRLRTPIGRRMPFILIGAPIAALVFGLIPLASVLPLFVACTSTLILSMAFWRTPVVALMPDITPSEYRSQANGIINLMGGLGAILGTLVGGPLFNINEAYPFWMGSALVILAALMVFIFIKEPKEYETTSEEQPSLWQSLIDVLTSQERSALRILLAIFFWFVAYNAIEAFFTLYAQNHLGLPGGDGARLLGQLSLLFVLFALPAGMLGGKFGRRKVIMSGIILLSACMLGMYFLPPETLLIQITRLPVLGVVPVVGVILMIAGIAWAMINVNSLPMVVDMTDQLRVGTYTGLYYLFSTLAAIAGPNLNGWIIQLTGKDYSNTMLVGPLFMLVALVMMLGVRRGEAKSVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N190</accession>
    <name>E8N190_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD-GYP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561180.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28070"/>
    <dbReference type="EnsemblBacteria" id="BAJ64833">
        <property type="protein sequence ID" value="BAJ64833"/>
        <property type="gene ID" value="ANT_28070"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
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        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="349"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="550" mass="62985" checksum="C1FC7AD2E2EE406A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C0</accession>
    <name>E8N1C0_ANATU</name>
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        <submittedName>
            <fullName evidence="3">DSBA oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">ANT_28370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
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            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ64863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28370"/>
    <dbReference type="EnsemblBacteria" id="BAJ64863">
        <property type="protein sequence ID" value="BAJ64863"/>
        <property type="gene ID" value="ANT_28370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28370"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_1_0"/>
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    <dbReference type="OrthoDB" id="1678187at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="27782" checksum="C45510976934AB32" modified="2011-04-05" version="1">MEEQLNPLEVSNAAPRRNLRWLYTLPVAFALGFAVAYFAFAVPLQKEVNSLKNQLAQSNQAVDVPQQVQRYDVPVDDDPAFGPADAPITIIEFSDYECPFCRKWHLEVWPRIQEEFGGQVRLVYRDFPLYGLHANAAPSANAANCAGEQGKYWEYHDGLFTYEGGYSRAAFEEIGKQVGLEMTAFTQCLDENRYKDEVEADYAYAADLGVQSTPTFFINGLALIGAQPYEVFRQVIQMELNGEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F3</accession>
    <name>E8N1F3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ64896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64896">
        <property type="protein sequence ID" value="BAJ64896"/>
        <property type="gene ID" value="ANT_28700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28700"/>
    <dbReference type="eggNOG" id="COG3502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129452_1_2_0"/>
    <dbReference type="OMA" id="QDGFIHF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="PTHR34129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="120" mass="13491" checksum="B5AE09AF48065528" modified="2011-04-05" version="1">MILFHILTASDWERARVEGTYRPESLNHEGFIHFSMRDQLLRVANTLFQGKRDLVVIEVESALLQAPLHLEPPLEGGRELFPHLYGALNLDAVRAVGRLSPEGDGAFVRFPDLHPISTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G0</accession>
    <name>E8N1G0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_28770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561248.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28770"/>
    <dbReference type="EnsemblBacteria" id="BAJ64903">
        <property type="protein sequence ID" value="BAJ64903"/>
        <property type="gene ID" value="ANT_28770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28770"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_1_0"/>
    <dbReference type="OMA" id="MYADRNI"/>
    <dbReference type="OrthoDB" id="1217595at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="401" mass="42624" checksum="0CE89F901887E7BE" modified="2011-04-05" version="1">MKDQHYKWYILTLTVLTSMIVVAIPQMGVSVLAKEISDSLGLSLVQVGVIWGVGALPGILTSLLGGMIGDKIGPKRVLAVGAFLGGLLGLTRGFAQDFATLAVLTVLLGAVLPMVLMNSIKVLGLWFPPHQLGMANGMQAMSMAMGFMLGSLFSATTLSPLLGGWRNVLIVYGVAGTLLGIPWLFTRISPRERESAGRSFSVLHSLRHVAGLKNIWLLGFALFGISGAIQGALGYLPLYLRNLGWEPLQADGVLTAFHTVSMLFVLPISLWSDRLGSRKRLLLVASLMIASGFALLSFVRGGIIWAAVMLSGSVRDAFMAMFMTKVIETDGVGPVYAGTATGFAIAIANIGNLLAPPLGNSLAEIYPSAPFAFWSGLCVLGFLCLLGIAEKRRERQESGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H6</accession>
    <name>E8N1H6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rbsC</name>
        <name evidence="7" type="ordered locus">ANT_05470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558977.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05470"/>
    <dbReference type="EnsemblBacteria" id="BAJ62581">
        <property type="protein sequence ID" value="BAJ62581"/>
        <property type="gene ID" value="ANT_05470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05470"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="OMA" id="GMVNFFG"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="327" mass="33624" checksum="70A94687E424596B" modified="2011-04-05" version="1">MLNGNHSFSFIAFLRRTSTYLILLVILVWFALLSPEFLTVGNLLTVALQTSLIALVAIGMTLTIITGGIDLSVGSVAALSGALAAGLATRGGLGTYPGLLIGLLTGLGIGFLNGAMIVWGRIPPFVATLASMAVARGLTLVYTQGRPIAGLDKAFTFWGGQGALGIPVPVWVLTVVAVLAYFLLKHTPLGLHIYAVGGGEETTRLAGVNVGLVKFSVYLLSGLCAALSGLILTARLWSAQPNVGVGLELDAIAAAVLGGTSLAGGVGGIPGTLAGAFIIGVLSNGLNLLEMPSYNQQVVKGLVFILAVMLDYFIKQRQVKPKGNPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1J9</accession>
    <name>E8N1J9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase small chain</fullName>
            <ecNumber evidence="3">1.2.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.99.2" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558999.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05700"/>
    <dbReference type="EnsemblBacteria" id="BAJ62604">
        <property type="protein sequence ID" value="BAJ62604"/>
        <property type="gene ID" value="ANT_05700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05700"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_0"/>
    <dbReference type="OMA" id="FIKHDGY"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="159" mass="17620" checksum="814F9CFC92DB1FF0" modified="2011-04-05" version="1">MTTHTIKVKVNGVEYVREVEPRLLLSDFLRHDLGLTGTHVGCEHGICGACTILFDGEPMRSCLIFAVQANGHEVTTVEALGTPEKMHPLQEAFQEKHALQCGYCTPGFLMTLKPFLETHPNPTDEEIREAIDGNLCRCTGYEHIIEAVKLAAQKMATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M5</accession>
    <name>E8N1M5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559025.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05960"/>
    <dbReference type="EnsemblBacteria" id="BAJ62630">
        <property type="protein sequence ID" value="BAJ62630"/>
        <property type="gene ID" value="ANT_05960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05960"/>
    <dbReference type="eggNOG" id="ENOG5033KP2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037788_0_0_0"/>
    <dbReference type="OMA" id="WFALAQI"/>
    <dbReference type="OrthoDB" id="2211739at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="287" mass="30994" checksum="93E1082E6C3CA1EE" modified="2011-04-05" version="1">MRNMASRITGITLIGMAILGVLFSIAAIILTNRFLDEARSAIIATGDLTERALLNTAKGLYTARTSLEEAQTTLSAIHQTLDGVTATVEGFSPALEAFHTLLGESLPAAIRTTQVTLQAAQTAAQTLDIFLYGLSQVPILSNFVKPPEVALHTAIGEVNSSLDNIPAALQDAQQGVQTASSENAKMESGLETISGQMSGIEEVVLEMKNVVDEYLLLVEDLQMKLLNFEKRLLTWVSIFRVLMTFILAWLALAQISLFLQGWDLLVHGFPGQGTAPETRGHSETPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T2</accession>
    <name>E8N1T2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62687">
        <property type="protein sequence ID" value="BAJ62687"/>
        <property type="gene ID" value="ANT_06530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06530"/>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073855_1_0_0"/>
    <dbReference type="OMA" id="HFHPDYF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="267" mass="30740" checksum="F5829BB982596AD0" modified="2011-04-05" version="1">MLDSLKKAIPVPVRRAIGETLDAFDRARQMPAAMLHPWRRDTMERLEALHNRHKGERCFIIGNGPSLRHTDMSKLRGEYTLGMNRIYLMFPELGFQTTYYLSVNDLVIEQCAAEIQALKLPRFVSWRARRWLTPEPDLYFLWTTYTGPKFATDLRGRLWEGATVTYTALQTAYYLGFSEVILIGVDHNFATQGKPNTTVVSQGDDPNHFSPAYFGKGFRWQLPDLETSERAYRMAREAFERDGRRVLDATVGGKLTVFPKVGYETLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N220</accession>
    <name>E8N220_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative M29 family peptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_29410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561311.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29410"/>
    <dbReference type="EnsemblBacteria" id="BAJ64967">
        <property type="protein sequence ID" value="BAJ64967"/>
        <property type="gene ID" value="ANT_29410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29410"/>
    <dbReference type="eggNOG" id="COG2309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057697_0_0_0"/>
    <dbReference type="OMA" id="HQGREIT"/>
    <dbReference type="OrthoDB" id="689314at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00919">
        <property type="entry name" value="THERMOPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="41666" checksum="AD5C751FC150BB0C" modified="2011-04-05" version="1">MADANVTRMAQVLVDYSTAIQPGDTVLIEATTLAEELVREVYRRVLERGGHPHLLLSLPDQEEIFYTAASRDEQLDFIPALHHYAAENFDARIRIYSEGNTRGLNSVNPARQARRQKALSVVQRAVFRRAAEDQLRWVSTLFPTQAYAMEAGMGWHEYRNFVFSACAVDGSVPDPVAYWQEVGRQQQKFISAFQGHDRVTLRGTNVDLTLSIRERRFLNSCGIHNMPDGEIYTGPVEDSVEGWVRFTYPAIYGGRAVEGVELTFEKGQVVKASARTNTEFLEQTLNSDPGARYLGEFAIGTNFHINRFTGNILFDEKIGGTFHLALGNSYPETGGRNQSTIHWDMICDLRTDSEILVDGEVVYRNGTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N253</accession>
    <name>E8N253_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561344.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29740"/>
    <dbReference type="EnsemblBacteria" id="BAJ65000">
        <property type="protein sequence ID" value="BAJ65000"/>
        <property type="gene ID" value="ANT_29740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29740"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_822960_0_0_0"/>
    <dbReference type="OrthoDB" id="2164168at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225408" evidence="2">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="337" mass="35881" checksum="3C408FD79C0528CF" modified="2011-04-05" version="1">MKRLLVVIWLALWLTACQVVNTPAPSPAPGETQTNPPAVSPSPQPTETSTPPPQRMVIYAPEGTNPAWVETARAQLEARASGAGVEVLPEWNDRAYGADVPLTLALAEPPALNEALSAAPQTRFVVLSAQLLTEAPNLTALLADPQHLAFTAGLTATVISDDWRAAGLIPTNQPTLQEAFLNGGRYFCGVCSPGWPLGMTFPLTAGVDTPSGGDWATTAAKLFDEGKVDVFYLSPNAVQPEVITYLKGLVQFTEPVRVLGSVPPPAELTDQWAVTLDWDFSSALEEALSASEPPALVRVPVVFTHLNEDLFTPGRQELVRSILAELQAGRIAPLSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B4</accession>
    <name>E8N2B4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06860"/>
    <dbReference type="EnsemblBacteria" id="BAJ62720">
        <property type="protein sequence ID" value="BAJ62720"/>
        <property type="gene ID" value="ANT_06860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06860"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_582310_0_0_0"/>
    <dbReference type="OMA" id="TPWAQEK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="128"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="320"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="473" mass="53574" checksum="DD687D982444E389" modified="2011-04-05" version="1">MEKIDGPLKRIADAMSKANTPTSSNTESQSSATFRGDPNCPICGGIGFVRRDLPIDHPDFGKVEICSCRSAEVMRATFQRAYRASNLQALEKMTFATFNPRGRHGQGEAMVRSLENAFEQAQKYAHSLNGWLLLIGGYGVGKTHLAAAIAHEAVSLGVPTLFLTVPDLLDWLRYAYDAPDDTFEARFEEIRNIRLLVLDDLGTQNATAWAQEKLYQIFNHRYIHRLSTVITTNQALEEIEGRIQSRLRDIELVNTVRIEAQDYRQPLEDTTKPRLSALPLYSRMTFGTFHFREKEKNITSEERANLRRAFEIAYEFAENPRGWLVLSGDYGCGKTHLAAAIGNYQASLGNPPLFVVVPDLLDHLRSTFSPTSNVSYDEVFEEVRSAKLLILDDLGTQSATPWAREKLYQIINHRYIAELPTVITTSSKPEEIDPRIRSRMLDRRLCTWFAIQAPTYLPTEERRTTRGRKPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H6</accession>
    <name>E8N2H6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559175.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62782">
        <property type="protein sequence ID" value="BAJ62782"/>
        <property type="gene ID" value="ANT_07480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07480"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_1_0_0"/>
    <dbReference type="OMA" id="YVMAMYQ"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="PTHR31528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225233" description="NMT1 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="35257" checksum="4C606B64EC032A9A" modified="2011-04-05" version="1">MKSKIVSLLFVVVLLLSACSPQGKATPQTLTPIRLPVGYIPNVQFAPLYVAIEKGYFREEGLDVTVDYNMEVDNLAQIAAGKLDFAMISGEQVLLGRAKGMPVVYVMAWYQKFPVGIAAPVSENIFKPEDLKGKRIGIPGLFGASYIGAKALLSAGGLSESDVTLDAIGFNQVEGITSGREQAAVVYIANEPVQLRALGYDITVLAVSDYMELVSNGLVTSEKIVQENPELVRKMVRALIKGLDATIANPDEAYELSKKHVENLAQADASVQKAVLTSSIELWKAERLGYSNPKGWENMQEVLLSMGLLSEPQDLSKAFTNEFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I5</accession>
    <name>E8N2I5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N_BRCA1_IG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559184.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62791">
        <property type="protein sequence ID" value="BAJ62791"/>
        <property type="gene ID" value="ANT_07570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07570"/>
    <dbReference type="HOGENOM" id="CLU_791419_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="N_BRCA1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228621" description="N_BRCA1_IG domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="N_BRCA1_IG" evidence="2">
        <location>
            <begin position="257"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="350" mass="38366" checksum="211B457C1D5A1A4A" modified="2011-04-05" version="1">MLAQSKKLLSFLVSTLLLTMLMLTAFAPTVRADGVPTITILEVKVDEWVKIKAKNLPKNTEFTARMDKMGNYAIGGTVVGTAKSGADGTFEATFNIPQSLKGLSRIALRIDSASGYYSYNWFDNKTATPTAQPTQSTSGKPYIEIIAVEKDKAVTVQAYRFPANQTFTVRVGPFKTFFKDYVVVDKINSGSGGSFKFTVTLPEKVKGVDWITIRLDSPEKQYAYNAFRNVSSGTVVSPTPPPPSGTVCQIISTSPTKTLKPREDFDAIWQVKNTSGKDWEQHSVDYKFVSGTSMHKKSIYDFKATVRNGETVNIIVDMLAPDKAGTYSATWAIVAGNKTLCTLPITITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J1</accession>
    <name>E8N2J1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07630"/>
    <dbReference type="EnsemblBacteria" id="BAJ62797">
        <property type="protein sequence ID" value="BAJ62797"/>
        <property type="gene ID" value="ANT_07630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07630"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_0"/>
    <dbReference type="OMA" id="WRHPDEP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="26"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="284" mass="32874" checksum="D4E22A263B8038EB" modified="2011-04-05" version="1">MMNKVTLNNGVEIPILGFGVFQITDPVECERAVRDAIEVGYRHIDTAASYRNEEAVGRAIKQCGVPREELFITTKLWIQRNGYEGAKRAFENSLRRLQLDYVDLYLIHQPYGDVYGEWRAMEELYRQGKIRAIGVSNFYPDRIMDLIMNNEVVPAVNQIEVNPFHQQIETQKFLLENGVQVEAWAPFAEGRNNIFQNELLVSLAAKHNKTVAQVILRWLVQRGIIALAKTIRKERMLENFNVFDFELSEEDMTAIATLDTKTSSFFDHRNPEMVKWLCGRKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J5</accession>
    <name>E8N2J5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_07670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07670"/>
    <dbReference type="EnsemblBacteria" id="BAJ62801">
        <property type="protein sequence ID" value="BAJ62801"/>
        <property type="gene ID" value="ANT_07670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07670"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_2_0"/>
    <dbReference type="OMA" id="HAKVPET"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="4">
        <location>
            <begin position="69"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="291"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="122"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="487" mass="53184" checksum="E3FDBEC06C62F00D" modified="2011-04-05" version="1">MCFHFRSTQRKSHLLQKTGNSMKRTLLTLLIIAVLSIAGYFAFTAWQNSRTIAATNWQTTTVTRGPLVAVVGATGTVRANQTAVLAWQTSGRIAEINVSVGDAVQKDQVLATLDEKSLSQSIILAKADLVTAKRNLENLKDSQLAQAQAYQALVAARKELEDAQKNRASKQYSRALPDTIEVARANLALAEEELKKAQDTYDIFKDRPESDLLRAQALTALNEARKKRDRAKANLEYLTGGPDELEIEQADARLRLAEAKLADAEREWERVKDGPDPDDLMAAEARVAAIEATLELVSLKAPFNGTVTEVRSMVGDSVNPGTVSFRIDDLSRLLVDVQITEVDINRVRVGQNATLTFDAIPGKEYHGKVTQVGRVGTNVQGVVNFTVTLELTDADEAVRPGMTAAVNIETDRLENVLLVPNRAVRLRESKRVVYKLINGIPTPFEVTLGLTSDTYSQVLSGVSEGDVLVLNPPVQFQAGPPSGRMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K6</accession>
    <name>E8N2K6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_07780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559205.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07780"/>
    <dbReference type="EnsemblBacteria" id="BAJ62812">
        <property type="protein sequence ID" value="BAJ62812"/>
        <property type="gene ID" value="ANT_07780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07780"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401534_0_0_0"/>
    <dbReference type="OMA" id="WFLHSRT"/>
    <dbReference type="OrthoDB" id="281582at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="133"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="741" mass="84146" checksum="87C25E1C99DF627B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L7</accession>
    <name>E8N2L7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_07890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559216.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07890"/>
    <dbReference type="EnsemblBacteria" id="BAJ62823">
        <property type="protein sequence ID" value="BAJ62823"/>
        <property type="gene ID" value="ANT_07890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07890"/>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="HGGQASC"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="252"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="467" mass="51938" checksum="E0E33644CFE203ED" modified="2011-04-05" version="1">MMKSLYWKLSLAILLAAFTTAGLFAVFMRVTNADRLMQFVIDQQRTKLVQALSEYYQAQGSWDNIQIQWKEIERQTLPVEWQRPLDDEGGTPPPRETWERRGFFSLADSQGKVLVSGTPEYPLNETLNQQALKDGSPITVNGETVGFLLSPRRLVNLRPEEARFLTRVNQALVIGGAGALLIALIIGIFLARTLTRPIKDLTLAATRMAQGELEQQVEVRSQDEIGQLAQAFNLMSQQIARANQLRRQMTADIAHDLRTPLTVIAGYIESMRDGVLQPTPQRLDLIYQEIERLQKMVNDLRMLSQADAGELNLHPQPTQPLALLKRAAHLFQHHAEQAGINLKVEASETLPAILVDEDRMMQVLDNLISNALRYTSAGGEITLRAKQDGKQVRLQVADTGTGIPSEELPRIFERFHRVDPSRHSESGGSGLGLAIVRALVEAQGGKVSAESELGKGTTITTEFPALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L9</accession>
    <name>E8N2L9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_07910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559218.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07910"/>
    <dbReference type="EnsemblBacteria" id="BAJ62825">
        <property type="protein sequence ID" value="BAJ62825"/>
        <property type="gene ID" value="ANT_07910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07910"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_2_0"/>
    <dbReference type="OMA" id="AYEDQKF"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="2">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="230"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="475" mass="50111" checksum="3109AE71623DC0E2" modified="2011-04-05" version="1">MKMKTFGQGKGKRIPSWVIGGVAVLVLGLAVWGYFALWVPRMQTASAATTTTGTQTAQVRRGNLVVSASGTGTLTAGKTAELAFPVSGTVGAVYVSVGQQVEEGQVLAELADRTSLEAAMKSAEVTLLLAQQELETLKASGEENLANARLAVSTAEKALQTAQASLKQSGQSRCSEETTTAYYDSYLKAKERYEDLKSSGADYLTRVLPAKQSMDQAYANYRYCSGYYDYEITASQAEYVIAKADLEKAQATLATLEANNGIDPTTLAQAESKVLNAQVAYEQAKKNYEGAILRAPFAGTVLSVAGEAGDAVGTGTFITLIDLLHPLVEFAVDETDMDKVAVGYPAEVVFDALPDLTFPGTVQQVSPSLVSEGGYKVLKGVVALDLSQMNLNQPLLAGLNAAVDIIAARAENAILIPVEALRDLGDGTYGVFVVGTDGKPRLRVVTVGIKDATYAQILEGLSVGEVVTTGTVETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P6</accession>
    <name>E8N2P6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62852">
        <property type="protein sequence ID" value="BAJ62852"/>
        <property type="gene ID" value="ANT_08180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08180"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065334_0_0_0"/>
    <dbReference type="OMA" id="SRHKGKF"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="368" mass="42613" checksum="835F27DD3ECFAA16" modified="2011-04-05" version="1">MFRFVRKMVEFSRHCLKKYARMDISYSQWLKSFGKFFYWRDTMKVCVVGGSGNISTSIVRLLVSLGHEVYCFNRGKSRPVPEGAKTLTGDRNDRETFEKMMQSYHFDAAIDMMCFTREDAESSVRAFRGVSHFVQCSTVCTYGIDYDWLPVTEDHPLRPITPYGRGKVEADHVFLEAYHREGFPVTIIKPSTTYGPIMGLPRQIAWDFSWIDRTRKGKPIVVCGDGNALHQFLHVDDAAPAFVYVLGRERCLGQVYNMVARGFTTWAEFHRTAAKVFGKEIELVGIPFADLKRMNVPEFGICEEIFAHHVIYSAEKLFRDVPEFQPRIRLEEGMAQVFEAMEREGRIPNSDALKWEDDIIARWKKIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W6</accession>
    <name>E8N2W6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_30900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561457.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30900"/>
    <dbReference type="EnsemblBacteria" id="BAJ65116">
        <property type="protein sequence ID" value="BAJ65116"/>
        <property type="gene ID" value="ANT_30900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30900"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="OMA" id="TDWFLVM"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="104"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="33329" checksum="68A6EC3E55444F16" modified="2011-04-05" version="1">MSAVSLKNNTEKAAERWSPTRDAWRRLRRHRSAQIGMIILGLMVLVAIFAPLIAPYDPVKQMQDVKRREPPCIHLLGCPAEKPEHIFGIDGNFRDLFSRVVFGSRLSLQIGFATIGFAILVGGLLGAISAYAGGWVDNLIMRIMDVLMAFPSLLLAIAIVAVLGTGLINALLAIGIVSIPRYARLVRATVLQVREMEYVQASRALGAGGLHILFLRILPNAITPLIVQGTLGIAGAIIDAAALSFLGLGAEPPTPEWGLMLGEERNSVFNAPHLVFFPGLAIMLTVLSFNLLGDGLRDALDPRLRGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X1</accession>
    <name>E8N2X1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561462.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30950"/>
    <dbReference type="EnsemblBacteria" id="BAJ65121">
        <property type="protein sequence ID" value="BAJ65121"/>
        <property type="gene ID" value="ANT_30950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30950"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017077_0_0_0"/>
    <dbReference type="OrthoDB" id="545558at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="752"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="839" mass="91862" checksum="F1F6178C5F8102A9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X6</accession>
    <name>E8N2X6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tungstate ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_31000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561467.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31000"/>
    <dbReference type="EnsemblBacteria" id="BAJ65126">
        <property type="protein sequence ID" value="BAJ65126"/>
        <property type="gene ID" value="ANT_31000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31000"/>
    <dbReference type="eggNOG" id="COG4662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_2_0"/>
    <dbReference type="OMA" id="EVGVAMM"/>
    <dbReference type="OrthoDB" id="1110665at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="13"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ65126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="23476" checksum="0C646C5FC1E5BFE8" modified="2011-04-05" version="1">MTGSMNAQLDEIVLLSLRVSGIALFFSSLLGIPAGILLGLNRFPGKRIAIILIYTGMGFPPVVIGLLVYFLLSQRSPLAGLPFLPDLFTPEAMILAQIILAFPLVAGFTMTAVQAVDPALRLQVMALGATRTQAALAVLREARNGVIAAIVAGFGGIISEVGAVMMVGGNIEGRTRVLTTAIVLETRQGNFNTALALSLILLGMAFVVNALLFILQDRWQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N300</accession>
    <name>E8N300_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561491.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31240"/>
    <dbReference type="EnsemblBacteria" id="BAJ65150">
        <property type="protein sequence ID" value="BAJ65150"/>
        <property type="gene ID" value="ANT_31240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31240"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087860_0_2_0"/>
    <dbReference type="OMA" id="STHARIT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="206" mass="22327" checksum="63C605404DA90CC6" modified="2011-04-05" version="1">MKADNLLSPAEQDVLQEMMNIASGRAAGTLSGILGKRIEMSLIEVAALDRQGIFDFLDEELGVVGSAVEQRFSGGLTGTSMVMMDYQSCSHLVQLLGGEALESASRDVNEQSILYEVGNIILNSCVAMLGKQTGRRMHFNLPRVYYNLRGHAIAENLTSPADPNIYAVAMKSALTVGEINFHIHILIFLILPLNNLKAILHAALNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N344</accession>
    <name>E8N344_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N6_Mtase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561534.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31700"/>
    <dbReference type="REBASE" id="32161">
        <property type="entry name" value="AthUNI1ORF31680P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65194">
        <property type="protein sequence ID" value="BAJ65194"/>
        <property type="gene ID" value="ANT_31700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31700"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077121_1_0_0"/>
    <dbReference type="OMA" id="AEWGYLG"/>
    <dbReference type="OrthoDB" id="1759360at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="224" mass="25889" checksum="A5E35CBF5AEA0226" modified="2011-04-05" version="1">MKELIKSKQRVADYGEVLTPPHIVDAMLDLVKQETERIDSRFLEPACGTGNFLVQVLRRKLQVVEKRYARSQLDYERYAVLAVSSLYGIDILEDNAAECRQRLYQTFDTFYTARFGAKTKAACRETVRYILKRNIIHGDALSLKTVGEHPQPIIFSEWSLVHGSLMKRRDFAFHELLQVKEKTDSLLEVNKTLVSDRGEKVFIPEPVKDYPPVHFLEIAHAYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N396</accession>
    <name>E8N396_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559302.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08760"/>
    <dbReference type="EnsemblBacteria" id="BAJ62910">
        <property type="protein sequence ID" value="BAJ62910"/>
        <property type="gene ID" value="ANT_08760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08760"/>
    <dbReference type="HOGENOM" id="CLU_1109633_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="250" mass="26743" checksum="41296C4482E867D4" modified="2011-04-05" version="1">METTLSTSPAEQEEKIPRRAFTGMLMIAITLLLQALAAGYTVPYSLRHSTFDNLLEGGTDPIMTALSCLTIVAGIAQLVGFIFLVSSVQNVSRSIKRLCWLAFILFVVAIVLTLIVNIPLGYAVSLGGSRTMGIASLWVTALSQILNFTSLAILLFALALSPLKWVGAGIAGLQSVVVLAIAGISTAFYRLLELTLMGNTMYVPQPKPNPYQPVLSIAGLILSGVFALVFLISTVGMRARLVEEPSDRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J2</accession>
    <name>E8N3J2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mrdA</name>
        <name evidence="5" type="ordered locus">ANT_09720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559397.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63006">
        <property type="protein sequence ID" value="BAJ63006"/>
        <property type="gene ID" value="ANT_09720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09720"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_1_0"/>
    <dbReference type="OMA" id="SCDTYYY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="60"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="315"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="700" mass="76331" checksum="5212C311E36FE54F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K6</accession>
    <name>E8N3K6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559411.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63020">
        <property type="protein sequence ID" value="BAJ63020"/>
        <property type="gene ID" value="ANT_09860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09860"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493242_0_0_0"/>
    <dbReference type="OMA" id="NIMIRAG"/>
    <dbReference type="OrthoDB" id="2082372at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="20748" checksum="B59E10C6560DD99D" modified="2011-04-05" version="1">MPQVAIRPAISSDLSALSQILLSYYTVRVWQMDRSMEEEQIQVRFREVRLPREVLVEYPRTIEDIFQEGWLEKGIFLTASLANVPVGFARLALEVTSGNLWVKDLGVRHDVRRQGVGTALLIAVQDYALERKYRRILLEMQSKNYPAIQLAKKLGYEFSGYSDAYYANQDIALFFAQSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N0</accession>
    <name>E8N3N0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rpsC</name>
        <name evidence="12" type="ordered locus">ANT_10100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559435.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10100"/>
    <dbReference type="EnsemblBacteria" id="BAJ63044">
        <property type="protein sequence ID" value="BAJ63044"/>
        <property type="gene ID" value="ANT_10100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10100"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_0"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="225" mass="25511" checksum="CF598E2279C5A297" modified="2011-04-05" version="1">MGRKVNPVGFRLVVNKAWESRWFADGKEYTQNLQQDFQIRKLVREIAENAGVSRVEVERFPGKVRVIVFTAKPGILIGRKGESVKKLRQDLEALTGKKIDLEIKEIKNPDTDALLVAENLASQIERRVSYRRAMKRALQQAMRQGAKGIKVEVQGRLSGAEMSRSVWLREGRVPLQTLRADIDFARAEALTTYGRIGVKVWVYKGEMAPEVEEKAEPTEGVYVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Z7</accession>
    <name>E8N3Z7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559549.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11270"/>
    <dbReference type="EnsemblBacteria" id="BAJ63161">
        <property type="protein sequence ID" value="BAJ63161"/>
        <property type="gene ID" value="ANT_11270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11270"/>
    <dbReference type="eggNOG" id="COG1811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091659_0_0_0"/>
    <dbReference type="OMA" id="IYCVGAM"/>
    <dbReference type="OrthoDB" id="1815957at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007563">
        <property type="entry name" value="DUF554"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36111">
        <property type="entry name" value="PTHR36111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04474">
        <property type="entry name" value="DUF554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="25816" checksum="9D40007D186834BB" modified="2011-04-05" version="1">MTGTILNVVAILLGSALGTFLGGRIPDKLKQTVVSGMGLFTFALGIQMFLKTGNALIVLGSLVIGALLGEWWKIEDLLSQLGSWLEKRFNHANDEGEHSNYQRERFIRGFLTASLVFVVGPVAILGAIQDGISGDYRLLAVKSVLDGFASLAFSSSLGIGVAFSAFPILVYQGAISLLAAQVQAITTPEMMNEMTATGGILLMGIAVSGLLEIKKIRTGNFLPALILAPLIVALLSALGVQVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N456</accession>
    <name>E8N456_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559608.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63220">
        <property type="protein sequence ID" value="BAJ63220"/>
        <property type="gene ID" value="ANT_11860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11860"/>
    <dbReference type="eggNOG" id="COG0647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_1_1_0"/>
    <dbReference type="OMA" id="PPMHRET"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="266" mass="29881" checksum="EDABC18AF2036E3D" modified="2011-04-05" version="1">MASPDLFRSIRCFLLDLDGTFYLGDRLLPGARDLIEFFEARGIDYIFLTNNSSRNPRKYLERLHKFGIPVQPKHIFTSADATLHYLSKNFPGARLYLLGTPDLEEQFEQAGFPLTDEAPDVIVAGFDTTLTYNKLWKLCTWVSRGLPYIATHPDINCPTEDGFMPDIGAVIAFVQASTNRSPDIIIGKPFPPMVEALCERFNLSPGQMCMVGDRLYTDIAMKNAGVNTVLVLSGETRLEDLTSSPYKPDFIFSNLVDLLETLQKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N496</accession>
    <name>E8N496_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559648.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12260"/>
    <dbReference type="EnsemblBacteria" id="BAJ63260">
        <property type="protein sequence ID" value="BAJ63260"/>
        <property type="gene ID" value="ANT_12260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12260"/>
    <dbReference type="eggNOG" id="ENOG502Z7WH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031037_0_0_0"/>
    <dbReference type="OMA" id="TIRDRFY"/>
    <dbReference type="OrthoDB" id="924061at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010144">
        <property type="entry name" value="CRISPR-assoc_prot_Csd1-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09709">
        <property type="entry name" value="Cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01863">
        <property type="entry name" value="cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="629" mass="72192" checksum="BB5E2A280497AFE8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E8</accession>
    <name>E8N4E8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative S-adenosylmethionine decarboxylase proenzyme</fullName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">speH</name>
        <name evidence="10" type="ordered locus">ANT_12780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63312">
        <property type="protein sequence ID" value="BAJ63312"/>
        <property type="gene ID" value="ANT_12780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12780"/>
    <dbReference type="eggNOG" id="COG1586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="129" mass="14403" checksum="F614AE1C4A311402" modified="2011-04-05" version="1">MNAQLKLGEHYICDLSDCNRELLYDSEQAGRLFSKAVRESGLTVVDEGFFPFSPHGFTCFLLLAESHASLHAWPEYGYCAVDLFTCDLDLDLTPLINQIKEIFGASQCSIRKVARVAELVGEPEHVNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F5</accession>
    <name>E8N4F5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559707.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63319">
        <property type="protein sequence ID" value="BAJ63319"/>
        <property type="gene ID" value="ANT_12850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12850"/>
    <dbReference type="HOGENOM" id="CLU_2079847_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="13339" checksum="5E5EEDCBFD0566A1" modified="2011-04-05" version="1">MKNYQKILYFFVLPILAVLLYPPQSLIKGIGVVIAAVLLFALIGYFLLRGKELALTFMIFVQGMNVIIRLMMFFSTGFTNQGQPNVLFLITCFLGLVLSFWLLVRLDRQDIRLSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4H0</accession>
    <name>E8N4H0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63334">
        <property type="protein sequence ID" value="BAJ63334"/>
        <property type="gene ID" value="ANT_13000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13000"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_770836_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="196"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="359" mass="40400" checksum="5D526AC9A66C0673" modified="2011-04-05" version="1">MRSTMNPPDITTVVFDWGNTLMRVDPRFSGPMMLWDEVSTMPGAEEVLFSLQKKFRLVVGTNAADSNAYQVGKALERVNIKKPFHAIFTARELGARKPDLKFFRQMESVLGMRPEQMVMVGDKFSEDVLGAKRAGWRAIWYNPDGESAPGLLPLQDGDIQHLSYLPDSLFSLDLPDVALCQSWMAEFGLPVSLQMHVQMVAAISYQLAVWLRKAGQKVNPLLVHRSGLLHDLAKMQTLGKENPSSMGHAELGARLMEDQGYPQIARVIRTHALHSLNELETWEQKLVYFADKLVEGSRLVALEERIKALKQRYPHEAERIAVFESGLFRLQDEILGHVGIDNEEECLSMLKASLTSKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L1</accession>
    <name>E8N4L1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Deoxyribodipyrimidine photolyase</fullName>
            <ecNumber evidence="7">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phrB</name>
        <name evidence="7" type="ordered locus">ANT_13430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA photolyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559762.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63375">
        <property type="protein sequence ID" value="BAJ63375"/>
        <property type="gene ID" value="ANT_13430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13430"/>
    <dbReference type="eggNOG" id="COG0415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_2_0"/>
    <dbReference type="OMA" id="WQWSASS"/>
    <dbReference type="OrthoDB" id="184000at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901363">
        <property type="term" value="F:heterocyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097159">
        <property type="term" value="F:organic cyclic compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051716">
        <property type="term" value="P:cellular response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="466" mass="53687" checksum="9885DC481F189021" modified="2011-04-05" version="1">MTTILWWIRRDLRLHDHPALEYALQKGRVIPVFILDDRLLQKEASKRKQFLFSGLRQLDEDLRKRGSQLIIRRGEPLAELTRLIQETGAEEIVALEDYSPYARRRDSHIARELPLHLFAGETVYPPSLVLKPDGSPYTVFTPFSRAWKALPFASPSVVSLPERFPAVPDKLVSLPIPEAIFLQDFPPGELEALRRLENFLSGPAREYADGRNRLDQPGTSFLSPYFRFGMLSPRWAVFQVRKMIQITSSPDEKRGYEAWLNELIWREFYISILYHYPHVLAMAFNPALRAIEWRDAPSELQAWKEGKTGYPVVDAAMRQLKATGWMHNRARMIVASFLTKDLLINWQEGEQWFMQNLVDGDPAANNGGWQWTAGVGTDAAPYFRIFNPVLQSAKFDPQGRYIKTWVPELTSVPTEFIHAPWTMPLSLQISLGVRIGRDYPTPMVDHQEVRGRVLEAYRTSQGKTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L4</accession>
    <name>E8N4L4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene synthase</fullName>
            <ecNumber evidence="2">2.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crtB</name>
        <name evidence="2" type="ordered locus">ANT_13460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559765.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63378">
        <property type="protein sequence ID" value="BAJ63378"/>
        <property type="gene ID" value="ANT_13460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13460"/>
    <dbReference type="eggNOG" id="COG1562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037269_1_3_0"/>
    <dbReference type="OMA" id="KLYCYRV"/>
    <dbReference type="OrthoDB" id="1449625at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="297" mass="33983" checksum="CF46F066A02482D1" modified="2011-04-05" version="1">MSVSILAREDPVSSTLLEQIIREHSKTFYFATALLPSRKRYAIRALYAFCRASDDLVDREQTTLSDLDAWREQVNLPAHEQSNPVLKAWSEVREEYAINRLYEKELLDGIEMDLNFQVYPTFEALKVYCYRVASTVGLLAIPIIGLAKGVSFEQAAPFAIQLGIALQMTNILRDIGEDARRNRVYLPLEDLQKFNLTHQDILNGVYDDRFIRLMKFEISRTRELYQQAIPGIAFLSKAARPAVGAAAFLYRAILDEIENIQYHVHTLRAHTKGWKKIAMLPSILWKLQGLPQPGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L9</accession>
    <name>E8N4L9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559770.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63383">
        <property type="protein sequence ID" value="BAJ63383"/>
        <property type="gene ID" value="ANT_13510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13510"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045945_3_0_0"/>
    <dbReference type="OMA" id="GDVRQEC"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="192"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="36908" checksum="299033DBD68F0162" modified="2011-04-05" version="1">MANIADLPDTPQYTIKVVAIQTGIRPVTLRAWERRHEVLNPQRADNHYRLYSERDVAILRWLKSRVDAGISISTAVAELRSMMAQGLMPEVSPVSPQKAKPQPTHTKEEYIKFLYQAFLAHDEIRSYETFKQAAEEYDLIPLFTEILVPVLTQIGEDWYLGKITIATEHFASNFLRGRLLDLFQTYPIRKNSSYVLIGCAPFEQHELGSLMLATLLRAHGYRVEYLGPDVPIDDLVDFASYEHPAMIILSASSSASAIELKNTQQKLAKLRRPPLFGYGGRGFDNHPEIRQKVAGIYLGNTLEKALEKVNELLGEHSSKPYARKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4P9</accession>
    <name>E8N4P9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559797.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63413">
        <property type="protein sequence ID" value="BAJ63413"/>
        <property type="gene ID" value="ANT_13850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13850"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1486135_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="181" mass="20060" checksum="BCCC488E7A6A8780" modified="2011-04-05" version="1">MEKQLTPDQLAEHGQRLYRSGKHLEAAEQFEKASKAFAELGDVLKSAEMANNRSVALLQAGDAQGALDACAGTEQIFHKAGDTEREGIAIANYAAALEGLNRLEEALEHYQRAAALFKQINHSEMRAVVLKAISSLQIRTNRQFEALASMDAALEEQKKLSLRERLLKKIIDLPFKMIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R9</accession>
    <name>E8N4R9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559815.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63433">
        <property type="protein sequence ID" value="BAJ63433"/>
        <property type="gene ID" value="ANT_14050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14050"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_0_5_0"/>
    <dbReference type="OMA" id="VQVEHIC"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="176" mass="19357" checksum="24E5F78216041A17" modified="2011-04-05" version="1">MRVTVFGGTYPKPDTLPYEEAVKLGRLLAQAGHVVISGGYMGVMEAVSQGAALAGGHVIGVTCDEIERWRNVPKNQWVKEEWRRATLPERMITLMDEADAIIVMPGGIGTLAETALIWNRMLIQATTPKKVILVGEGWRKAITALYEAFPEYYPNGHQEMVLFASTVEDAVKLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V2</accession>
    <name>E8N4V2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative M20 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559848.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63466">
        <property type="protein sequence ID" value="BAJ63466"/>
        <property type="gene ID" value="ANT_14380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14380"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_2_1_0"/>
    <dbReference type="OMA" id="HITIPGF"/>
    <dbReference type="OrthoDB" id="275025at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="197"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="464" mass="51363" checksum="C7BEBDE6D4D6FA1B" modified="2011-04-05" version="1">MSIHREEAILFARSHIEEYISSLKKLVEIPSISTLPENQGDVQRAATELAYQMETLGLQNVQVMPTQRHPVVYGEDLSAGPDKPVVLIYGHYDVQPVDPLELWETPPFEPQVKGDFLVGRGTSDMKGQIAATLAAYHALRSTHGMPVNVKFIVEGEEEIGSPHLRNFVENHRQLLASDISLNPDAGMLAPHLPTIVYALRGLAFFELLVYGPSHDLHSGVFGGVIHNPAQVLCEVIAGLHDKNGTVTLPGFYDRVRPLPDWEKKELARLPLESEVLLEQTGVPALWGEAEFNFAERIGARPTLEVNGLYSGFTGQGSKTIIPSYAMAKISCRLVPDQNPHEVHEQLLHHLKNVMPSTVRWELKYLGGGNPCMTDIRHPANQALAAALETAWGTPPIYKREGGSVPVIGDFKEILGIETVLTGFGLPDDRIHSPNEHLHLPTWKKGIEALIHFFFNLAEQEGLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W2</accession>
    <name>E8N4W2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XdhC_CoxI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559858.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63476">
        <property type="protein sequence ID" value="BAJ63476"/>
        <property type="gene ID" value="ANT_14480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14480"/>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041115_4_1_0"/>
    <dbReference type="OMA" id="YCIVMTH"/>
    <dbReference type="OrthoDB" id="1879870at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="106"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="262" mass="28049" checksum="1FEDADE5252AAE5F" modified="2011-04-05" version="1">MSVFQALAELESQGKGAVLCTVIRSAGSTPRHEGSKMIVYPDGHILGTVGGGELESRVIKEALDVYQQGKPRLLSYSMVNPKEGDPGVCGGTVQIYVEPILPKPVLLVIGGGHVGKAVAHLGKFLGFRVAISDDRPEFCNPEAIPDGDEFYPVPMRDLPQAMTITPQTYIVMTTRGSVVDVPGLPALLDSPAAYIGIIGSKRRWLTTKKALLESGIAEEKIARVHSPIGLELNAETPEEIAVSILAEIIMLRNGGTGERMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W6</accession>
    <name>E8N4W6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14520"/>
    <dbReference type="EnsemblBacteria" id="BAJ63480">
        <property type="protein sequence ID" value="BAJ63480"/>
        <property type="gene ID" value="ANT_14520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14520"/>
    <dbReference type="eggNOG" id="COG3608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082089_1_0_0"/>
    <dbReference type="OMA" id="ETNRGHN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017695">
        <property type="entry name" value="Se-dep_Mo_hydrolase_YqeB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03309">
        <property type="entry name" value="matur_yqeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="30733" checksum="6F7EFD71C5984D12" modified="2011-04-05" version="1">MNWKRKVRRERLKQGLWAIVRGGGDLASGAILRLARAGIKVIVTELAQPLMVRRKVSFAEAIYQGEVEIEGLRGVKAEIDVEQIIRIASEYQIPVIADPELKIQSLFTPDILVDGRMLKKSLEDQRTLASLVIGLGPGFVAGKNCHAVIETKRGHFLGRVIWEGEPEKDSGIPEGVDGKFGERVLRAPSEGEFMAGVEIGESVLSGQCLGYVNGVPVYAPFDGVVRGLIWSGLHVMQGQKIGDIDPRGDPRYCWLVSDKSLAVGGGVLEAVLTIPEFRARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y3</accession>
    <name>E8N4Y3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559879.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63497">
        <property type="protein sequence ID" value="BAJ63497"/>
        <property type="gene ID" value="ANT_14690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14690"/>
    <dbReference type="eggNOG" id="ENOG502ZAD8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993721_0_0_0"/>
    <dbReference type="OMA" id="INEHEVH"/>
    <dbReference type="OrthoDB" id="853210at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="277" mass="31416" checksum="1030CE5E28B1D841" modified="2011-04-05" version="1">MDGFPRTEVGGVSLPRLIIGTNWFLGYSHTSLAKDRFIKDLQTRNRIVEVLLVFLTYEIDAVMGPLHPLLEESIQEAEQRSGKPITRIYTPWFNILPGGPEENEPEVVFDQCAQWHATFCMPHQAVTDALLDRMHRTIRDLDRYTQMIRERGMIPGLSTHMPETPIIADETGADVETYIQIYNAAGFLMQVEADWVMKIIRNAKKPVMAIKPLAAGRLLPVVGLSFVWSTIRPIDMVVIGTTTPEEAHEVVNISLDLLHQRIPDYELQKTRSKKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N502</accession>
    <name>E8N502_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559898.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63516">
        <property type="protein sequence ID" value="BAJ63516"/>
        <property type="gene ID" value="ANT_14880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14880"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065333_0_0_0"/>
    <dbReference type="OMA" id="ERAGQKD"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228639" evidence="1">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="287" mass="32736" checksum="C383A86A0BCBEB55" modified="2011-04-05" version="1">MKPVSRFILAILAVLMLSACGSTPTRYLTFTIRAQNSEIWMLDTSNDKLLNLSNKSSDDFWQTWAPDGRYLAFTSDRSGNLDIWILDTQKEVVFNYTNNPEDEGWPAWSPDGKYLAYASNREGTYDIWRMNSDGSNRVNLTPGDGDDGLPAWSPDSQRIVFSSNRNGNYDLYIASVNGGELEQITSDEADDIMPAWSPDGKKIAFVSKRDGNSEIYLYDIASKGVTNLTKNPYNDETPAWYPDGSRILFVSERFDNQWDVYSMKPDGSEVRRLTHDELQEFHPMWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N512</accession>
    <name>E8N512_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559908.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63526">
        <property type="protein sequence ID" value="BAJ63526"/>
        <property type="gene ID" value="ANT_14980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14980"/>
    <dbReference type="eggNOG" id="COG3268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046808_0_0_0"/>
    <dbReference type="OMA" id="AYGLSSW"/>
    <dbReference type="OrthoDB" id="1006830at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="39176" checksum="F3569CC47EF0F1CD" modified="2011-04-05" version="1">MITLFGATGYTGRKIAAELERRGLPFRIAGRSRERLTELSNSLPSRPAWIVADAQKNETLPPLFKDTRLLINCAGPFTDLGEKVAQMASFAGVHYLDTTNELAFVYRLQTYHKMAVTNHSFLLPACAFEIALSDVIIAKLLQETSAQHVYVVYHTPDTKISKGTRLSALRSLTTSWIGFQDGSWNGMVPAGKSSQFQFPSGVQTAIQIPSAEVFSVPWRHPVRSVEVWMTVSRSWGFWGPVVLPYFARFMRSIFGKWVYTLISRHDPLPVEDAESPFEILIGVQEQQEQDWRQALVSGKGPYTLTAKIAGYAASRVLGNTNLPNGLITPSVLFSYGEFIEEMQANGIQFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N528</accession>
    <name>E8N528_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559924.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63542">
        <property type="protein sequence ID" value="BAJ63542"/>
        <property type="gene ID" value="ANT_15140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15140"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031866_2_0_0"/>
    <dbReference type="OMA" id="YPTGSWG"/>
    <dbReference type="OrthoDB" id="692608at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="118"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="486" mass="54793" checksum="8E52F38FEBF6FE66" modified="2011-04-05" version="1">MRDYYSILGVSFDATPEEIRSAYFDLAKKYHPDVTDDPKAHDRFVEIQEAYDVLSNAARRAKYDASLPDTVKKGPEVTLNVRTSRMVIPRIQEPQLFYALVDLICTAEYNVKEAPPFHICLVLDRSTSMHGARMDMVKSSALNLLKQFRKQDLISVVAFSDRAEVVIPPTRVPDLAKDDHRISMLQVGGGTEIYQGLQLGIEQLRSIDPRFMRQLILLTDGHTYGDDEACIELAEEAAQDGIQINTMGIGHEWNDELLDKIATISGANSIFVTSPKDLNKFFEQKLQLLNDTYARGLSLEFTLGEGVELKYAFRLHPETSPLPATNPIPLGTLMYHKSMSLLFEFVIHPISADVTSLQILTGKIKMELPSAQSLRARLPIQIKRAVMDQPEPESPPPALIEALGKLTLYRMQEKIQKEVEEGQIDKATRRLHYLATQLLSQGDRELAHAVLLEAEHLQQSRTFSREGDKRIKYGTRALLLPSGMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N562</accession>
    <name>E8N562_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63576">
        <property type="protein sequence ID" value="BAJ63576"/>
        <property type="gene ID" value="ANT_15480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15480"/>
    <dbReference type="HOGENOM" id="CLU_2406924_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="92" mass="10681" checksum="963B624D117EACA5" modified="2011-04-05" version="1">MKFIQRFGKISPMLFFQLMIKVLYNFPGVFLFYKPTPTFENPFVGEETSIHPPFGWTIAGFLLILLVSMLYSQIKKGLRQLFLKRKKKSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N571</accession>
    <name>E8N571_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppa</name>
        <name evidence="6" type="ordered locus">ANT_15570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559967.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15570"/>
    <dbReference type="EnsemblBacteria" id="BAJ63585">
        <property type="protein sequence ID" value="BAJ63585"/>
        <property type="gene ID" value="ANT_15570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15570"/>
    <dbReference type="eggNOG" id="COG0221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_2_1_0"/>
    <dbReference type="OMA" id="DEPTFPG"/>
    <dbReference type="OrthoDB" id="1767807at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="202" mass="23111" checksum="9A543799BF5789E4" modified="2011-04-05" version="1">MAFPKPFYRWRPHPWHGLEIGPNPPRIVHAYIEITPFDLVKYEVDKVTGYLRVDRPQRSSSQPPTLYGFIPRTYCGATVGSLFPEKHEGDGDPLDICVISERPITKSEVVLNARVVGGLRMIDNGEADDKIIAILANDSYWENVNDISQLPTVLVERLRHYFSTYKLVPGKENLTYIESVYDHEKAMQIVQAAIEDYIQMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N574</accession>
    <name>E8N574_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559970.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15600"/>
    <dbReference type="EnsemblBacteria" id="BAJ63588">
        <property type="protein sequence ID" value="BAJ63588"/>
        <property type="gene ID" value="ANT_15600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15600"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_3_1_0"/>
    <dbReference type="OMA" id="SFMSQSG"/>
    <dbReference type="OrthoDB" id="445933at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="701" mass="76267" checksum="A30451A70B9B9EA0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N576</accession>
    <name>E8N576_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_15620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559972.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15620"/>
    <dbReference type="EnsemblBacteria" id="BAJ63590">
        <property type="protein sequence ID" value="BAJ63590"/>
        <property type="gene ID" value="ANT_15620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15620"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_0"/>
    <dbReference type="OMA" id="YEACPND"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="278"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="312"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="539" mass="60011" checksum="637EE553546C6B81" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E5</accession>
    <name>E8N5E5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560039.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63659">
        <property type="protein sequence ID" value="BAJ63659"/>
        <property type="gene ID" value="ANT_16330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16330"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102863_2_0_0"/>
    <dbReference type="OMA" id="NWRERRM"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="45"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="202" mass="22749" checksum="C8916F34120CB6DE" modified="2011-04-05" version="1">MKTKSLWSILAILLGIVISCLCITPFLLGSIGSLLVISTPLQPADAIVVLSGGRDLQRLEKAVNLMKEGQAGYLILTKTEDITESGRQTADYLASEAHQRGIPVPKIVITQKTSKNTEQEAIATLEILRERGWKTLIVVTDPYHTLRSRIIFREVMRKDSIKVYTVPSKKPDVPSWLWYIDGNSRRAVWREILSLLAYLLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K3</accession>
    <name>E8N5K3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA polymerase sigma-54 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpoN</name>
        <name evidence="10" type="ordered locus">ANT_16910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560096.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63717">
        <property type="protein sequence ID" value="BAJ63717"/>
        <property type="gene ID" value="ANT_16910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16910"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_1_1_0"/>
    <dbReference type="OMA" id="VTTQKFM"/>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="367"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="467" mass="52814" checksum="8FC7BCB14E74F456" modified="2011-04-05" version="1">MLHHLPLHTIKPLATAHLAQTMSLLSLTATELQEHIEAELSSNPALEMLDELRCPVCHRKLPPQGVCPVCSQPVLGQGEEAVVFISTREVYTGFGDPQEEDDREDNGVLEEESLAVHVFRQIAPDIPPEDRKIAAFLLTHLNEDGLLTISLQEIASYHHVSLERVRRIQQMIQRADPAGVGSIEPKEALLAQLDLLEEVQPVPSLARKVIEEGLDLLSRHQFHELARLMKVSVGEIQRVASFISKNLNPYPGRSFWGDSKGGKSLTQQVFYKPDILISLASNGEQEVLVVEILFPLWGTLRVNPLYRKALQQVDEELREEMRQDLERASLFVKCLQQRNHTMQRLMQRLVAWQKDFIIKGEKHLKPLTRAQLAKELGVHESTISRAVANKAVQLPSGRIIPLSDFFDRSLSARIVLKELIMHETKPLSDAELVKLMAQRGYEVARRTVAKYRAMEGILPANLRRACY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L1</accession>
    <name>E8N5L1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxylate reductase</fullName>
            <ecNumber evidence="6">1.1.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_16990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.26" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560104.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63725">
        <property type="protein sequence ID" value="BAJ63725"/>
        <property type="gene ID" value="ANT_16990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16990"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_0"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047964">
        <property type="term" value="F:glyoxylate reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="6"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="111"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="36481" checksum="B483AF2C2F1CEC6D" modified="2011-04-05" version="1">MDKPHVFITRRIPDIGLEMLSEHVEIDLWEEELPPAYDVLRERTQRADGLLCLLTDRIDKELIENSARLRVISQYAVGIDNIDIDSATKRKIPVGHTPGVLTDATADFTWALLMSAARRVVEADAFTREGKWKTWGPTILLGMDVARSTLGIIGFGRIGQAVARRAKGFDMRILYYDNKRLPEMEETLGVEYVSLETLIKEADFISLHVPLTPNTYHLIGEKEFSMMKKEAILINTARGSVVDQEALYHALKERKIRGAAIDVTDPEPIPSNSPLLQLPNLIITPHIASASVQSRTQMAVMAAENLIAGLQGKRLPFCANPQVYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5L4</accession>
    <name>E8N5L4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_17020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17020"/>
    <dbReference type="EnsemblBacteria" id="BAJ63728">
        <property type="protein sequence ID" value="BAJ63728"/>
        <property type="gene ID" value="ANT_17020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17020"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012430_1_0_0"/>
    <dbReference type="OMA" id="SRRHYCF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="16"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="390"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="11">
        <location>
            <begin position="611"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="666" mass="76929" checksum="7627A1C6FA6D33ED" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q1</accession>
    <name>E8N5Q1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560143.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63765">
        <property type="protein sequence ID" value="BAJ63765"/>
        <property type="gene ID" value="ANT_17390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17390"/>
    <dbReference type="HOGENOM" id="CLU_2731159_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="71" mass="7911" checksum="274BA888E6CB8E0D" modified="2011-04-05" version="1">MDTHLLSKICKEVYRQFPEVAGIAPKITERPDGHLLVFKGNAITADGRKLLRTVRAVVNHQGKITKLTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U1</accession>
    <name>E8N5U1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative NAD-reducing hydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560183.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17790"/>
    <dbReference type="EnsemblBacteria" id="BAJ63805">
        <property type="protein sequence ID" value="BAJ63805"/>
        <property type="gene ID" value="ANT_17790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17790"/>
    <dbReference type="eggNOG" id="COG3411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126515_4_0_0"/>
    <dbReference type="OMA" id="TQTGCMG"/>
    <dbReference type="OrthoDB" id="1412344at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="122" mass="13478" checksum="CEBFF38913CACC73" modified="2011-04-05" version="1">MDRVKSLEDLKKLREQALEKRKLKTASGEVQIIVGMGTVGIAAGARETLKAILEFIEKENLSGITVRQTGNIGWDSYEPIVQVVIGDQPKVTYGKVTPDVAIRIMKEHVLNGQVVKDFMLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V7</accession>
    <name>E8N5V7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560199.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17950"/>
    <dbReference type="EnsemblBacteria" id="BAJ63821">
        <property type="protein sequence ID" value="BAJ63821"/>
        <property type="gene ID" value="ANT_17950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17950"/>
    <dbReference type="HOGENOM" id="CLU_2314291_0_0_0"/>
    <dbReference type="OrthoDB" id="2014086at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="99" mass="11372" checksum="76E38DFA162B02E4" modified="2011-04-05" version="1">MAQFSYMKPPETSKTYEVGDVVEVYCDHEKGGQRTRGWLKGIVVQVDAKMVAIQFRSNVFLTDGWMVPDHILWYPVNSPHVRFPGEKKGSGRSDYTKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N612</accession>
    <name>E8N612_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63876">
        <property type="protein sequence ID" value="BAJ63876"/>
        <property type="gene ID" value="ANT_18500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18500"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766486_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="218"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="361" mass="40524" checksum="CF1937D2186A8483" modified="2011-04-05" version="1">MTKRNNISRRDFLQMSLLAAGALALTPLQRNLQNSTEWTVGQKMGRVCLGKVNIRAKPDANADITKVIFDDAVVVWLREVIGASPGYGSRRWVETPDGFIYAPRLQPVYYLPNTPLTQLPEVNGERGMWAEVTVPYVDLIIANPPIRTPSLKNALYPRLYYSQVVWIDDVRVSASGKTLYRVNQKYGTYGDIFWADAEAFRPITEEDVAPISPEVENKKIIVNVTRQTLSCYEGNREVHFCRVSTGAKFDAQGNPVDKWSTPLGPHPIYRKLMSLHMSGETTGDYTAVPWTCFITGEGVAVHSTYWHNEFGIPRSHGCINVSPEDAKFIFRWTNPVVPLIPGELDVSKNWPPVGTVVEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N644</accession>
    <name>E8N644_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_18820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560285.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18820"/>
    <dbReference type="EnsemblBacteria" id="BAJ63908">
        <property type="protein sequence ID" value="BAJ63908"/>
        <property type="gene ID" value="ANT_18820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18820"/>
    <dbReference type="eggNOG" id="COG1553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097491_1_0_0"/>
    <dbReference type="OrthoDB" id="1936074at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="113" mass="12435" checksum="9504FB1EADC4A495" modified="2011-04-05" version="1">MKQDLVILFTHYGMGDGPQDLQQTLIRKFLTLWFESGQIPAKMIFYTDGVKLACQGSPVLDQLKAFEAQGTEIVLCQTCLDRYGLIDQVSVGIVGGMGDIIEALQKAPKVITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N652</accession>
    <name>E8N652_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560293.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63916">
        <property type="protein sequence ID" value="BAJ63916"/>
        <property type="gene ID" value="ANT_18900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18900"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_3_0_0"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="258" mass="28588" checksum="01D2513C90ED7C50" modified="2011-04-05" version="1">MDVETIRARLSALPISEIQYLPETYSTNDDAMAWAQAGAPEGVVVIADKQLKGRGRLGRMWVTQPGTSLAFSMIFRPTLEEIEKLSLFSPLGALAVAVALEDLGLSPEIKWPNDVLLSRKKVCGVLAETVWMGSHINGVVLGIGINVATGSVPDSNMLLFPATCVESELGKPVDRLSLLESVLRHLIEWRKQIRTERFIEEWKKRLAFLGEKVTVQKPDGEITGRFQDVDEHGALVLSVEEQYHTIFAGDVKLRPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXE1</accession>
    <name>E8MXE1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560393.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19960"/>
    <dbReference type="EnsemblBacteria" id="BAJ64022">
        <property type="protein sequence ID" value="BAJ64022"/>
        <property type="gene ID" value="ANT_19960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19960"/>
    <dbReference type="HOGENOM" id="CLU_125503_0_0_0"/>
    <dbReference type="OrthoDB" id="1716507at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="165" mass="17740" checksum="001E970D07FECF3E" modified="2011-04-05" version="1">MKKSFWITLSVLMLVGVFALVGVSVVNAQSVTPPAPGTGTPGLYRETMQEYMHAALAEQLGISVEDLEARLADGQTVYQIALEKGLSVEEFRTLMLNARNTALENMVKDGVITQEQADWMKTRGFGRNGRAGLNNGGCPMMGQGLGARQNGGGFRQGRGMMGGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH1</accession>
    <name>E8MXH1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64052">
        <property type="protein sequence ID" value="BAJ64052"/>
        <property type="gene ID" value="ANT_20260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20260"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082131_0_0_0"/>
    <dbReference type="OMA" id="ISSISCY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="34620" checksum="4DB45B566DF0005D" modified="2011-04-05" version="1">MPNRTAFELRLTMHHIYLSPHLDDAVYSCGGRMFRQRREDEPVTVVNFLSGTPPEGELSAFARQYHEMWGNPSNAVALRRQEDIEALSRWGIQAIYWDSSDAIYRQIHGTPLYPNISSLFGTPHPEDERELLTCWNETWARLRFSPEQVHMYAPLGAGNHVDHVLVRKFAQQLKRQGWRVWFYEDFPHAYDSRTLQEALDGFGNVRWKSHTELIDAEEKVKAMWIYASQISMMFSDREDLRKRVKDFSAERAVDIHWGERLRKILAGSGGRRERIWRRLFGYLAHAERYWSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI2</accession>
    <name>E8MXI2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64063">
        <property type="protein sequence ID" value="BAJ64063"/>
        <property type="gene ID" value="ANT_20370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20370"/>
    <dbReference type="HOGENOM" id="CLU_3339285_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="37" mass="4244" checksum="E379623DCD0618B4" modified="2011-04-05" version="1">MNPLKLYYSYLHYRKKEETGNLSSRTIEVKVSGIGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ3</accession>
    <name>E8MXJ3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560444.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20480"/>
    <dbReference type="EnsemblBacteria" id="BAJ64074">
        <property type="protein sequence ID" value="BAJ64074"/>
        <property type="gene ID" value="ANT_20480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20480"/>
    <dbReference type="eggNOG" id="ENOG5033KAI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709474_0_0_0"/>
    <dbReference type="OMA" id="INHEIRP"/>
    <dbReference type="OrthoDB" id="2189351at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="153" mass="16549" checksum="9B8250378E53C512" modified="2011-04-05" version="1">MSEFSPESPSQAAPVEPLSPTSVGVEEKKSSVPIGLIILGVVLLVGLIVGAVLLIQSDNETTARVRDVFIIFMALESLVIGVALVILIVQLAILINLINHEIRPIIQSTNQTVNTLKGTVTFLSDNLSEPVIKLNEYLAGIRKLTEILRISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ9</accession>
    <name>E8MXJ9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thiol-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_20540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64080">
        <property type="protein sequence ID" value="BAJ64080"/>
        <property type="gene ID" value="ANT_20540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20540"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_2_0"/>
    <dbReference type="OMA" id="WLVINYW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="55"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="200" mass="22363" checksum="CBDA97F228597820" modified="2011-04-05" version="1">MKVQPEQTFCIYKVILMVKISAYRWFALLSLFLTALWIGVSSIFFKASEQTVAFAQRGFLAPDFELRSIDGGTIRLSDLRGKVVILNFWASWCPPCREEMPALQRVYQAYQSQGVEVIAVNATSQDTLSDVLNFVQDNGLTFSVLLDEQGGVQSTYRISGLPTTFFIDREGKIRELIIGGPLSEALLLAQAQRLSQQGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL5</accession>
    <name>E8MXL5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_20700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560466.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64096">
        <property type="protein sequence ID" value="BAJ64096"/>
        <property type="gene ID" value="ANT_20700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20700"/>
    <dbReference type="eggNOG" id="COG4262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008530_1_0_0"/>
    <dbReference type="OMA" id="WQGGKRA"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="210"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="518" mass="57479" checksum="FB580F97F57E2E52" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP8</accession>
    <name>E8MXP8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ordered locus">ANT_21030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560499.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="SMR" id="E8MXP8"/>
    <dbReference type="STRING" id="926569.ANT_21030"/>
    <dbReference type="EnsemblBacteria" id="BAJ64129">
        <property type="protein sequence ID" value="BAJ64129"/>
        <property type="gene ID" value="ANT_21030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21030"/>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014132_1_0_0"/>
    <dbReference type="OMA" id="TGQLWGT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="511" mass="58376" checksum="C9D67A6256CD3310" modified="2011-04-05" version="1">MSLFKRASGILLHPTSLPGPDGIGDLGPEAYRWVNFLAESGCSLWQILPLGPTGFGDSPYQCFSAFAGNPYLVSPALLLDEGLLTSEDLADRPEFPASRVDYGPVIQWKLTLLDRAYVRFKRSTSQKRKAAFEAFKEEQRAWLLDFSLFMAIKEAHGGASWDYWPEPLRKRDPEALNAFHRAHEVDVERHSFRQFLFFRQWQALRQYAHEKGVQIIGDVPIFVAYDSADVWSHPDLFYLDETGKPTVVAGVPPDYFSATGQLWGNPLYRWDYHRETGFAWWLERLKATFAMVDIVRLDHFRGFAGYWEVPYGMPTAEKGRWVPGPGIALFEAIRNALGGLPIIAEDLGEITPDVIELREQLGLPGMKIFQFAFASDADDPFLPHNYVQNCVAYTGTHDNDTAIGWYNSAPEKERDFVRRYLARSGEDIAWDMIRAVWSSVAMFAIAPLQDFLKLGPEARMNYPGRPAGNWGWRYEAFMLDDGLKNRIKEINYLYGRLPEHMKPPKVVKKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS9</accession>
    <name>E8MXS9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21340</name>
        <name evidence="3" type="ordered locus">ANT_23990</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="2">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21340"/>
    <dbReference type="EnsemblBacteria" id="BAJ64160">
        <property type="protein sequence ID" value="BAJ64160"/>
        <property type="gene ID" value="ANT_21340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64425">
        <property type="protein sequence ID" value="BAJ64425"/>
        <property type="gene ID" value="ANT_23990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21340"/>
    <dbReference type="KEGG" id="atm:ANT_23990"/>
    <dbReference type="HOGENOM" id="CLU_3039865_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="54" mass="5732" checksum="EE60B8E20139E7BC" modified="2011-04-05" version="1">MFAKLYVRLQSARAELDEKALLIALFVIAAIVGLSPLGQAIAAKFQQLATTLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU2</accession>
    <name>E8MXU2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21470"/>
    <dbReference type="EnsemblBacteria" id="BAJ64173">
        <property type="protein sequence ID" value="BAJ64173"/>
        <property type="gene ID" value="ANT_21470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21470"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631126_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="163"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="434" mass="45779" checksum="6444DA726CAF57C0" modified="2011-04-05" version="1">MWNHPGMNLQQAADAVTVLLAGQIPRLQAWYTALAADARFRVAMQATDPQDLNSKLVTNPDVLLLDATIYPGPQPLLETLTRYHGAAYVLLPLEASREAMDSIAQVPCVKGVYKGDLNLVAIAGEMYAAAQAQRQARMSAGMEALWNRPQSGMGAGGAPLGLRVVAVWNQAGGVGKTTLASNLAYEAARRGLPTLLVGLGAPDDLPLILGLKPEPNLNHWRANPTAEGLKLALQKVDTLDVLAGFPDVLSEARAMNTPLDAPESVPKLVLTAAYMGYAVIVLDAPPTALASAALAAANTLVLVARPSLEGVMRTVEAYRTVVERLAGEHHIPAAGVYVALNRTGARMGADEWHKAASTLLGRPFPPVAAQIPDEPRVGEAQDARKLPLNASDTFARSLKPLADALFSTQGAAAGVPQNGSGKKTFEIFGVRVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY8</accession>
    <name>E8MXY8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_21930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560588.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64219">
        <property type="protein sequence ID" value="BAJ64219"/>
        <property type="gene ID" value="ANT_21930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21930"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361637_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012286">
        <property type="entry name" value="Tetrahaem_cytochrome"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14537">
        <property type="entry name" value="Cytochrom_c3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228501" evidence="6">
        <location>
            <begin position="24"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="7">
        <location>
            <begin position="76"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_c3_2" evidence="8">
        <location>
            <begin position="455"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="731" mass="78933" checksum="0B9A227077BEFE30" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ7</accession>
    <name>E8MXZ7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Respiratory-chain NADH dehydrogenase, subunit 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_22020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560597.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22020"/>
    <dbReference type="EnsemblBacteria" id="BAJ64228">
        <property type="protein sequence ID" value="BAJ64228"/>
        <property type="gene ID" value="ANT_22020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22020"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_0"/>
    <dbReference type="OMA" id="KIMARIQ"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="34163" checksum="F8FB7665900E57D3" modified="2011-04-05" version="1">MNNWSVHPLIALFLFPGGLFLFLWGLFYEWIDRKLVARLQNRVGPRWYQPLADLVKLLAKEEIVPEGSDPTLFYLLPVLALACALTSALYLPMAGFMPAYSFRGDLIVALYLLSMLTIGLGVAGANTPNRFSLIGATRTLTQLFSYEAPFLLALLGPAIVAGSWRIAEINFYTQQQPLWLMVTQPIGFLVALVGLMGKLELPPFDAPEAETEIVAGALTEYSGRGYALFRLGKNVELVIALTLVATFYLGGLANPLQFLLKTLGLLVFLAVLQTLFARLRIDQTVGLWWRIGALLAVAQLLILFVMKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY10</accession>
    <name>E8MY10_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Succinate dehydrogenase, flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sdhA</name>
        <name evidence="10" type="ordered locus">ANT_22150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560610.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64241">
        <property type="protein sequence ID" value="BAJ64241"/>
        <property type="gene ID" value="ANT_22150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22150"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_0"/>
    <dbReference type="OMA" id="HWEWHMF"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="8">
        <location>
            <begin position="8"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="9">
        <location>
            <begin position="473"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="597" mass="66120" checksum="D0B3B0DD6D6B9F0D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY49</accession>
    <name>E8MY49_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560648.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64280">
        <property type="protein sequence ID" value="BAJ64280"/>
        <property type="gene ID" value="ANT_22540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22540"/>
    <dbReference type="HOGENOM" id="CLU_870572_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="35342" checksum="E3152D3AC57A2F04" modified="2011-04-05" version="1">MNLDIKTGVVVASFTFLFLSFFSFWTGWRTIQAGRRLTYFQKRRQRLSQGWRLVFFSLIFFAMGVIINRFAEPVAYRYFPPTPTVTLTPTVTLTPTITLTPTITLTPTITNTPSITNTPAMPSVVATQFLSTITPNPSAVFSPLVFATKLDKSFQPVDPADIFKNPVPQIYAIFSYDQMTVGSQWSALWYRGSELVCFETLPWNGGTGGFGYSECIDPLGGWLPGEYEVQIFVGTEWKRSGRFTVEGEPPTPQPSRTPTRTPVPTATPGPSPTRPSPTPSFTGTATNTPTVTRTPTITNTRRPTDTRWPTATATSTPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY55</accession>
    <name>E8MY55_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FemAB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560654.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22600"/>
    <dbReference type="EnsemblBacteria" id="BAJ64286">
        <property type="protein sequence ID" value="BAJ64286"/>
        <property type="gene ID" value="ANT_22600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22600"/>
    <dbReference type="eggNOG" id="COG2348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048411_0_1_0"/>
    <dbReference type="OMA" id="FGLIQFK"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="366" mass="42371" checksum="1CB4B95C7A4EE077" modified="2011-04-05" version="1">MNSIENWNETIAHLPGASILQTQEWAQIKSAYGWEPIPRVWKSPQGELLAAAMILRRRFQLRGIALPVSLLYVPRGPLLNWSDKALAVRVIADLEGLAKTQKALFIKIDPEVVLGWGVPGREEARENPDGQWVQSQLNLRGWQYAVEQIQFRNTAILDLSGDEEGWLTRMKPKTRYNLRLAERKGVKIRQASEHDLGLLYRMYAETSVRDGFIIRPESYYRQVWSTFMQKGMAYPLIAEVEGEAVAGLVLFVFAGRAWYLYGMSRDVHREKMPNYLLQWEAMRLARQLGAREYDLWGAPEVFDESDSMWGVFRFKEGLGAQVVRTLGAWDYPVAPLGYRLFTRVIPRLLDVMRWRARRKLRREVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY84</accession>
    <name>E8MY84_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_22890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560682.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22890"/>
    <dbReference type="EnsemblBacteria" id="BAJ64315">
        <property type="protein sequence ID" value="BAJ64315"/>
        <property type="gene ID" value="ANT_22890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22890"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042512_0_0_0"/>
    <dbReference type="OMA" id="RRVQKWP"/>
    <dbReference type="OrthoDB" id="1304273at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="6">
        <location>
            <begin position="172"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="239" mass="27358" checksum="BB67441A5AB8AEFF" modified="2011-04-05" version="1">MNQEQQRTTLEVIAPTVEEAIQKGLEQLNLSADAVDVEVLDSGSRGLFGIGSRQARVRLVVRASQPSEEKPASVIEEDVPNHEEIIWISEKVVSDLLERMRIKARVKASIRPPSSKDEEETVLVNIEGEDLSILIGRRSETLNALQYIASLIVGRRLNRWTPMIIDVQGYRQRRERQLRMLARRMADQAVHTGRRQVLEPMPPNERRVIHLELRDHPLVITESIGEDPHRKVTITPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY88</accession>
    <name>E8MY88_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rnpA</name>
        <name evidence="7" type="ordered locus">ANT_22930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560686.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64319">
        <property type="protein sequence ID" value="BAJ64319"/>
        <property type="gene ID" value="ANT_22930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22930"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_9_0_0"/>
    <dbReference type="OMA" id="WDAGMLM"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="122" mass="13966" checksum="051A4C8E2489F769" modified="2011-04-05" version="1">MKRRFRLRHRSDFERVRRAGKTIPHPLVLFVVAPNSLDTVRIGVVAGRVVGSAVQRNRAKRWLRACLQEFLPALPPGWDVVAFARRPIIEAGFWKTRAAVEESLKRAGLLPVNGKYERRLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA3</accession>
    <name>E8MYA3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Rrf2 family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558446.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00140"/>
    <dbReference type="EnsemblBacteria" id="BAJ62048">
        <property type="protein sequence ID" value="BAJ62048"/>
        <property type="gene ID" value="ANT_00140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00140"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_3_0"/>
    <dbReference type="OMA" id="LRMLMYC"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="14937" checksum="440CEC474B66E271" modified="2011-04-05" version="1">MQITRQADYALRAMVYLARLSPNQRASTSQIAEEQHIPPSFLAKIISQLSIAGLIHTSRGARGGVTLARPPEEITVLDVVEAIDGPIALNECTSPSGVCMFGEDCPMKPIWCDTQKELIDRLRRTTFAQALATQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC2</accession>
    <name>E8MYC2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62067">
        <property type="protein sequence ID" value="BAJ62067"/>
        <property type="gene ID" value="ANT_00330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00330"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082131_0_0_0"/>
    <dbReference type="OMA" id="EAPHRGY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="246" mass="28094" checksum="FBDF63A5E0A39DAB" modified="2011-04-05" version="1">MEASLHWIYLSPHFDDAVLSCGGMIVEQTRRGERVEIWTVCGGFSDRNRPLPPFARQMHEELGVGANLVSLRRAEDRTACALIGASVRHGMLPDCIYRFLPDGSPLIRRSEDLWLPVHPAEMDLAVRLRRNWASRIPRDAQVVAPLSYGNHVDHRLTRMAAEGLDRPLWYYADFPYAQWHNLPLDAGLPEERILRVEVGAEALARWQDAIAAYTSQVERLFGSEAGMREQVEAFYRRGGGTFLWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF2</accession>
    <name>E8MYF2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558495.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00630"/>
    <dbReference type="EnsemblBacteria" id="BAJ62097">
        <property type="protein sequence ID" value="BAJ62097"/>
        <property type="gene ID" value="ANT_00630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00630"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030508_1_2_0"/>
    <dbReference type="OMA" id="IFYRPAV"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="264" mass="29560" checksum="213754DEB1C696D6" modified="2011-04-05" version="1">MEHPLTLVTFNLRTAEAQDGEFSWARRRDMVVECLRDLDADLIGLQEVHDDSQARDVRSAFPEYEWIGVRRGGNGAAPLEMNVALVRRGAFEVLEQQFFWLSRTPEVPGSISWGSAYVCTAIFLRLRSCRNGAEAAWFNTHLDYLPQARLEGAKLLRRRIEALPPDCNVLVTGDFNAGKRSCVYRTLLGEGASCHRLRDAYRAVHTDGRGEGTFHAFGMLPRPQAIDWVLVSKDLPVEDAGVACVSVGGVYPSDHYPVWAKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF6</accession>
    <name>E8MYF6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase M50 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">ANT_00670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558499.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00670"/>
    <dbReference type="EnsemblBacteria" id="BAJ62101">
        <property type="protein sequence ID" value="BAJ62101"/>
        <property type="gene ID" value="ANT_00670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00670"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086979_1_0_0"/>
    <dbReference type="OMA" id="HEIMHGL"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ62101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="212" mass="23268" checksum="CF70BB54C6B09A69" modified="2011-04-05" version="1">MFNVDPISLISRAITLIVALTLHEYAHARTAQAFGDPTPEMYGRVTLNPLAHLDPLGSLMMIFVGFGWAKPVPINPYVLSRRSTAAPMLVALAGPFSNFLLALAAAIPFRAGLIPVNEAISGSSFLPQFLLNFIVINLLLMFFNLIPLAPLDGDKIIEFFLPPSWAQALERIRPMGPMLLMVILFVLPWVGIDVFGTLLYPPIGNLLRALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYH6</accession>
    <name>E8MYH6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00870"/>
    <dbReference type="EnsemblBacteria" id="BAJ62121">
        <property type="protein sequence ID" value="BAJ62121"/>
        <property type="gene ID" value="ANT_00870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00870"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672026_0_0_0"/>
    <dbReference type="OMA" id="IVRICET"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="409" mass="45098" checksum="B2B6243F0BA61459" modified="2011-04-05" version="1">MYLSGSRWSMTRRKRRANPLRLIVLIAAVGVMLYVNQFVVPNTPPLFVPTPTPTRSPESFLQEARAFAAEGRFTQAEAAYQQALQADPKNITIYLELARLQALYGKYAEAQKNAENAILLNPNSSLAHAIHGWALGLQGEYLPAQAELNKAIEIEPGNGLAYAYLAEVLALQKIEGKDDPTTLEKAIEASRKAVELAPDQMESYRARGYVLEITSNYADAVVAFQQAIALNDNLADLHLALGRNYKAQDIYDKAIEEFNKAIALRPDDPRPYVETALTYLRYGEYAKAAQYAEQAIQQDPTDPFLYGYLGTIHYRTSNYNQAVKFLRLATRGGLSETGATVQGLPLDATSQYLYTRYGISLAYVGECGEALQISQALQQAFPDDQVNLDNAAEIVRICETGGASPTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI6</accession>
    <name>E8MYI6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trkA</name>
        <name evidence="7" type="ordered locus">ANT_22960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560689.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22960"/>
    <dbReference type="EnsemblBacteria" id="BAJ64322">
        <property type="protein sequence ID" value="BAJ64322"/>
        <property type="gene ID" value="ANT_22960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22960"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_2_4_0"/>
    <dbReference type="OMA" id="NRIAGPE"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="136"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="219" mass="24501" checksum="A175055B3ACBB9EE" modified="2011-04-05" version="1">MRALIIGCGRLGAELAYRLYQRGHEVSLLDLDERSFEILPADFQGRFHEGNALNLDVLRRCGIEEMDSVAVLTNSDVVNGVVGYLAMKHFHIPNVVVRNYDPRYRPILEAYHLQMVSALSWGAQRVEEMMYHAEVRAVFSAGNGEVEVYEVLVPEHCHGKRLKEVVDSSMCVPVAVTRAGKAALPDWNMVLEAGDVLHLSATLEGAEAIRQEMLRKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYL8</accession>
    <name>E8MYL8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_23280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560721.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23280"/>
    <dbReference type="EnsemblBacteria" id="BAJ64354">
        <property type="protein sequence ID" value="BAJ64354"/>
        <property type="gene ID" value="ANT_23280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23280"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_0_0"/>
    <dbReference type="OMA" id="PVCLRYG"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="28"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="466" mass="51795" checksum="279C0A7F3D528799" modified="2011-04-05" version="1">MTPQNYRSLFSGLDVPVPLLNGKQQVYINLDNAASTPPLKAVEDAIDRFLPYYSSVHRGTGFKSQLSTHAYESARRKVLEFLGAREDEHTCIFGKNTTEMINRLAKRFPFTPERDMVIVSLMEHHSNDLPWRGVAKVLRVGLLSDGRLNEDHFDSLLEQYGSRVALVAISGASNVTGYLNPIHRLAEKAHRVGAQIMVDAAQLAPHRAIAMGVLDDPAHLDYVVLSAHKMYAPFGTGALVGRKDTFSRGEPDHRGGGQVEFVTEDEVEWTGAPERDEAGSPNTIGAVALAAAMSQLERVGMDEVARHEAELTAYALEKLNAIPWVRLFGDRDPARASERLGVLPMQIEGVPHFLVAAVLGYEFGIGVRSGCFCAHPYLLHLLEVSPADAERVRKRILKGDRREMPGMIRASFGLYNTPEEIDAFVEALAAIRRGDYEGVYYQDVATGEYRPENYSIRFEDYFTFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ0</accession>
    <name>E8MYQ0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23600"/>
    <dbReference type="EnsemblBacteria" id="BAJ64386">
        <property type="protein sequence ID" value="BAJ64386"/>
        <property type="gene ID" value="ANT_23600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23600"/>
    <dbReference type="HOGENOM" id="CLU_2969230_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="58" mass="6271" checksum="C06D1F1274855A9A" modified="2011-04-05" version="1">MLEKIQPLCADNGMRRSSYSRSGSCEDNLPPELLATAGVESVSLPAASHLPRLSEKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS7</accession>
    <name>E8MYS7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23870"/>
    <dbReference type="EnsemblBacteria" id="BAJ64413">
        <property type="protein sequence ID" value="BAJ64413"/>
        <property type="gene ID" value="ANT_23870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23870"/>
    <dbReference type="HOGENOM" id="CLU_2535287_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="83" mass="9414" checksum="EB1194F26D6048BA" modified="2011-04-05" version="1">MSSASSAVVEIQSLPTPDRGEWRPGSLVVSRRTKWIIQKIIRIQDNGRVIVYLTRPKGQKIHLAVFIETQRGWVMGSPTKIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYU7</accession>
    <name>E8MYU7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560789.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24070"/>
    <dbReference type="EnsemblBacteria" id="BAJ64433">
        <property type="protein sequence ID" value="BAJ64433"/>
        <property type="gene ID" value="ANT_24070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24070"/>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965228_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="288" mass="30471" checksum="2704CC96D9B0C6F4" modified="2011-04-05" version="1">MEAAQILIPLSLALLVWGVAQNVKVGGGRAAKALSEYYAERTEKKTKQETIGEAVAGKLLSVKTWEDHLRWAQRGGQYVGQSLGGVVFQSLLFAGAGLLVVMVNPAPLSLLVPVMAFAYPLVRLRSKANTVRKRVFRTLPETAALIAAELAAGTAPDVAVARAAAIPGPLSTLLREAVEMSRGTGRPLFSRKPISGTLVEAMGASGIPALHAFGSQLDLVASKGVAGAALMSEIARALGQEYRAKLQSEVEKLDSRLVLVVALFFFVPFVALLLFAALNPILTVFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW7</accession>
    <name>E8MYW7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560808.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24270"/>
    <dbReference type="EnsemblBacteria" id="BAJ64453">
        <property type="protein sequence ID" value="BAJ64453"/>
        <property type="gene ID" value="ANT_24270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24270"/>
    <dbReference type="HOGENOM" id="CLU_1727560_0_0_0"/>
    <dbReference type="OrthoDB" id="2168580at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="151" mass="17128" checksum="0C77D112254DFC3C" modified="2011-04-05" version="1">MSYAFRRHDYNLNDFERCPEHGCVMMQVQDLPPVCLIEWLLEKAAERTVRDVILREQGEYDLPAVILDNGFLLPVEQVIRVRPAAPTELTLEEVAGWYVADILSMPGKDAVAVELLPPGAVVDEEPGILLQLSVDILLYLLFDQEIRKVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX4</accession>
    <name>E8MYX4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24340"/>
    <dbReference type="EnsemblBacteria" id="BAJ64460">
        <property type="protein sequence ID" value="BAJ64460"/>
        <property type="gene ID" value="ANT_24340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24340"/>
    <dbReference type="HOGENOM" id="CLU_1238097_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="223" mass="25682" checksum="604BF91BA13D3818" modified="2011-04-05" version="1">MRKMAERRTFWVGKQPGEDDNGAVESAPLGLPPISVVDLMRAPKKPRNRAWEKANRAKTFRSVPEEVSARVVAIADQLGVTADEVARAFLEYGLYCMERETLTIQPKIKGTRMTLYPLDSGWTKQHGWVEDGWNPTPKAVNTEKRNRKSRKEEEPRLWTRWVAYRLPEELVKRLKEKADQHSVPVGELVGLLLKHSANRYEQGVLRLIPYPKQDAQARWEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYZ9</accession>
    <name>E8MYZ9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62142">
        <property type="protein sequence ID" value="BAJ62142"/>
        <property type="gene ID" value="ANT_01080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01080"/>
    <dbReference type="eggNOG" id="COG3526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068510_5_3_0"/>
    <dbReference type="OMA" id="CFEVEVN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="59" mass="6682" checksum="F115243D7295C782" modified="2011-04-05" version="1">MLKKYEPEIERLTLIPSDGGRFEVEVNGRLVYSKLKTGRHAEPGEVAEQIQTILEKGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ01</accession>
    <name>E8MZ01_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">glnS</name>
        <name evidence="12" type="ordered locus">ANT_01100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558542.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62144">
        <property type="protein sequence ID" value="BAJ62144"/>
        <property type="gene ID" value="ANT_01100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01100"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_0"/>
    <dbReference type="OMA" id="INNFCAQ"/>
    <dbReference type="OrthoDB" id="142899at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="27"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="11">
        <location>
            <begin position="338"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="560" mass="64941" checksum="AFF191893F23AEF2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ06</accession>
    <name>E8MZ06_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558547.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62149">
        <property type="protein sequence ID" value="BAJ62149"/>
        <property type="gene ID" value="ANT_01150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01150"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087539_3_1_0"/>
    <dbReference type="OMA" id="IRVIDIC"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="25286" checksum="1F9C51E587D1D6C0" modified="2011-04-05" version="1">MSENLPALPRQDRRISRTRRQLREALMALILEKGYDAVTVEDIAARADVGRTTFYLHYRDKEHLFLESITQIADELAEQMYALFPQGQAVQEDQVGDHAMRPIVLVFRHAAENADLYRAMMRGEGGLIAITRLRELSASYALEFMRLFLKEAQTSLPLEVIASYFAASLLGTLTWWLEAGMPYPPDEMAHMFRRLAMRGVWEALGVTPPSSSAGQEEIQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC0</accession>
    <name>E8MZC0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_02290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558660.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02290"/>
    <dbReference type="EnsemblBacteria" id="BAJ62263">
        <property type="protein sequence ID" value="BAJ62263"/>
        <property type="gene ID" value="ANT_02290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02290"/>
    <dbReference type="HOGENOM" id="CLU_2406923_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228558" evidence="2">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="92" mass="9480" checksum="49EE18C819ADBEB9" modified="2011-04-05" version="1">MKAWRYGLVVVVLLGLFVWFAHPAVAEGTVCGDDGCAEDKPGSGCTEDCKPGEPGGGGKKEEPPSYPEEPPYAGGNSTCSLIESVPAVEPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC1</accession>
    <name>E8MZC1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_02300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558661.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02300"/>
    <dbReference type="EnsemblBacteria" id="BAJ62264">
        <property type="protein sequence ID" value="BAJ62264"/>
        <property type="gene ID" value="ANT_02300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02300"/>
    <dbReference type="HOGENOM" id="CLU_715043_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228502" evidence="2">
        <location>
            <begin position="24"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="386" mass="43684" checksum="A2253FF67860E2BC" modified="2011-04-05" version="1">MKSILRFLSVFVLGLSFLLSACAGIAPTPTPTPLPTETATPQPTPTPEPTSTPAPTPTPTVDPCATQPERWTFSLPVDPISKQPYPNFWMNLSPACALKNLEPWIAFSMMIQNGYSIQEAAQTLGLEDNPYLAPLKEGKPQKYVRWFGIEEQKVDGFNLPGRYYWWLPSMYLPVDVRFYYFDADTDRYEARLVLWGCARNVNAKLADGVSPEAQKVVFQAVCAVRKYYPGVQSSWWEQDLPEGTAGGFTRKHIPGKRAFEPDETQYGEGVHAAKPDQPAYAGMLYYAYIGDGQWYYIGEDNAFDLMGFDSVEEMEAALQRNLELVPGSQVWDLQWLKQTYGVDARPVPQEYRTMLDHYKSDPAFKALVDKALEIQGEYSDRYEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT4</accession>
    <name>E8MZT4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_02350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558666.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02350"/>
    <dbReference type="EnsemblBacteria" id="BAJ62269">
        <property type="protein sequence ID" value="BAJ62269"/>
        <property type="gene ID" value="ANT_02350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02350"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="ARVNDSH"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="345" mass="38914" checksum="109EA35737B5430B" modified="2011-04-05" version="1">MSDYAIEALDLVKKFPRRAPAESSAAPKNPLARLFQRPPKSEFTAVDHVSFQIHRGEIFGLLGPNGAGKSTTIRMLCTLLEPTSGTARINGYDVVRDANRVRQSLGIVLAGERSIYWKLTGRENLEYFAALYHIPPEIARKRIDELLDYMELTSRANELVEKYSTGMRQRIVLSRALLARPPIILLDEPTLGLDPQAARRIREMVLDLKRQGHTILLTTHYMEEADQLSDRIGIIDQGKIIALDTPAALKQRIRQQDVIKMEVAGWKPEMTGAIQSLPGIRQMVTRFLEQDGIWEIHLQTENSRAVLPHLIERVNTNGTHLVNLNIVAPTLEDVFIHLTGKALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU1</accession>
    <name>E8MZU1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62276">
        <property type="protein sequence ID" value="BAJ62276"/>
        <property type="gene ID" value="ANT_02420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02420"/>
    <dbReference type="HOGENOM" id="CLU_3131686_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="49" mass="5448" checksum="E5D5660E2D8D215B" modified="2011-04-05" version="1">MSSSTQRPSPRRPYPPFWEKSIPFILALVGLAVLALILISLAVLLGWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX1</accession>
    <name>E8MZX1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_02720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558703.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02720"/>
    <dbReference type="EnsemblBacteria" id="BAJ62306">
        <property type="protein sequence ID" value="BAJ62306"/>
        <property type="gene ID" value="ANT_02720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02720"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025182_2_0_0"/>
    <dbReference type="OMA" id="RRYFQRE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="380"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="520" mass="58165" checksum="B2E2E6D31D9CD0CC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N010</accession>
    <name>E8N010_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558742.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03110"/>
    <dbReference type="EnsemblBacteria" id="BAJ62345">
        <property type="protein sequence ID" value="BAJ62345"/>
        <property type="gene ID" value="ANT_03110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03110"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989184_0_0_0"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="31739" checksum="5DD369039B3D311E" modified="2011-04-05" version="1">MQEIVPQVYIETAYPGVTLGAINSPHGLILIDAPFRPEDARSWRSALISLGGGVDRLLINLDAHFDRTIGVRNMECTVLAHERMAEVFRNRPMTFKAQGSETGAEWEQYNGLGSVRWSPPEITFSDQLTIHWDDHPIRLEYHPGCSTGAIWAVLTESRVIFLGDAVVLNQPPFLASANLPLWIEQLESLLQGEYQDYLLVSGRGGLVAHQQVRAQIHFLRTVQEKLDALAKQNAPVSETEALVPALLEPFNPLPLYRQRLRYGLTHYYSRHYQSKGEEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N037</accession>
    <name>E8N037_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">crcB</name>
        <name evidence="10" type="ordered locus">ANT_03380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558769.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03380"/>
    <dbReference type="EnsemblBacteria" id="BAJ62372">
        <property type="protein sequence ID" value="BAJ62372"/>
        <property type="gene ID" value="ANT_03380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03380"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_3_0_0"/>
    <dbReference type="OMA" id="EWRLFLI"/>
    <dbReference type="OrthoDB" id="1942863at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="125" mass="13651" checksum="5F55238F993D75D7" modified="2011-04-05" version="1">MDRILWISIGAVFGANARYWLGVWAAQRWGTTFPWGTLIINLSGSFLLGLFMTLVTGRYPVDPHWRLLVAVGFFGAYTTFSTFTYESINLFLKGQWLAGLLNVVGSAVLGLLAAGIGVYLGKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N078</accession>
    <name>E8N078_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558810.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03790"/>
    <dbReference type="EnsemblBacteria" id="BAJ62413">
        <property type="protein sequence ID" value="BAJ62413"/>
        <property type="gene ID" value="ANT_03790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03790"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_0_0"/>
    <dbReference type="OMA" id="FQVEMNY"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="27794" checksum="FB09AD2B11CCA3FB" modified="2011-04-05" version="1">MKITFVIPTYNEAENLPRLVSALFSLPVPGLHLLIVDDNSPDGTGQIADELASQSEGRLSVLHRSGKLGLGTAYIQGFQRALEEGADAVGQMDADFSHPIEKITALVNTLETCDWVIGSRYVPGGQLDERWPLWRKFLSWFGNFYARTILNIRVKDVTGGFKLWRAETLRAMPLERIRSNGYVFQVEMNYVASLLGFKFKEIPIYFADRRWGKSKMDFRIQLEAAVRTWQLLWMYRDLRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N095</accession>
    <name>E8N095_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560998.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26180"/>
    <dbReference type="EnsemblBacteria" id="BAJ64644">
        <property type="protein sequence ID" value="BAJ64644"/>
        <property type="gene ID" value="ANT_26180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26180"/>
    <dbReference type="HOGENOM" id="CLU_073053_0_0_0"/>
    <dbReference type="OMA" id="THETAWE"/>
    <dbReference type="OrthoDB" id="1491811at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="258" mass="30272" checksum="ADBFB9B569E158D2" modified="2011-04-05" version="1">MRLSDCCILVSSFDKYEACWEPYWHGLEKYWPSHPQVYFITNFLQAPGGITLSVGSDRGWAGNLIKALSQIDFPYILYSQEDYWIQKPVEQILIEDYLDIIRSGKADYIRLYPAPPPDLPFPDDHRLGIIAPTSPYRTSLQMALWRKETLLSLLDTHETAWEFEVKGSKRSQYLKKRFLCVSKRQYGIDYVFTAVVNGYWSEKAYQYADNEKIHVRFEALPRKSIMVKVKDTIVSRLYRVKKKFLSKIRSIKITNFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0D1</accession>
    <name>E8N0D1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64680">
        <property type="protein sequence ID" value="BAJ64680"/>
        <property type="gene ID" value="ANT_26540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26540"/>
    <dbReference type="HOGENOM" id="CLU_3195435_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="45" mass="5038" checksum="62DF062C15E18879" modified="2011-04-05" version="1">MSLLEGRGIVLLVCVEIDLFPSVILDGECDQFASFDNFYEIEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0D2</accession>
    <name>E8N0D2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561034.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64681">
        <property type="protein sequence ID" value="BAJ64681"/>
        <property type="gene ID" value="ANT_26550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26550"/>
    <dbReference type="eggNOG" id="COG3212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098908_0_0_0"/>
    <dbReference type="OMA" id="VWVHTWH"/>
    <dbReference type="OrthoDB" id="1389010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="273" mass="30214" checksum="5F2B8E8468326735" modified="2011-04-05" version="1">MNKTLGIALLVIAGIVLSALIFGAGLMAGRFYNAAFNSTPFNNAFSSAPRANWERNTPYQGYSMMGGGGMMGNGNNMMYEYNRQGNNNVKPLSIDQAKQAVENYLPNLNNPDLETKEIMIFDNHAYVRIIEKSTGIGAMELLVDPVSLAVFPEHGPNMMWNLKYGMMSGWNGMMGGGMMGGRGMMRGYYTTPDSVSAEMTVTPEQALEAAQQYLDQEFPGYTTGEDAEPFYGYYTIDIVKDGKTTGMLSVNGYTSQVFFHFWHGTFIEMSEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L5</accession>
    <name>E8N0L5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561112.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27380"/>
    <dbReference type="EnsemblBacteria" id="BAJ64764">
        <property type="protein sequence ID" value="BAJ64764"/>
        <property type="gene ID" value="ANT_27380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27380"/>
    <dbReference type="HOGENOM" id="CLU_722885_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="382" mass="42969" checksum="9DE7A7B44193D816" modified="2011-04-05" version="1">MIFSKRIKLLGITGIILLIGIVGLLVLKTINSSSNSSRPSIMLATIRENNGQRQLEFLCVETNNCLPSLDIENKHLENLASLHIGPTYYIENSNIFVSFWEANTLMLKLNTQTLETTYFDLGTDIDLGILTLPLNKNLILASSRGTLLVVNDNLLPQKIQLNLQDSNYIRQLVHRNESEVVALNNIPIKSGDTISAQIFIVNPKTGAVVEKHLPVPEFKELFPGEALIEKQKYNLTIASVSPDLRTLYYTYYYTDDGESLKTALGMFDTQTMNDKGFNYDINCVSMNGYSQYKGFLYSSKLYSEGGGDIASLIEMKFLKPLIPLDRLLGRPSKALITPFGKYFVLGTNHQVIVLTQNGTVVDEYELPLDWVGRDYVIVEYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q5</accession>
    <name>E8N0Q5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558846.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04160"/>
    <dbReference type="EnsemblBacteria" id="BAJ62450">
        <property type="protein sequence ID" value="BAJ62450"/>
        <property type="gene ID" value="ANT_04160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04160"/>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120441_0_1_0"/>
    <dbReference type="OMA" id="NALMFWA"/>
    <dbReference type="OrthoDB" id="1925503at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="133" mass="14846" checksum="E21AFE8A4AD47B7D" modified="2011-04-05" version="1">MQKLLIRLGINAVALYTAIYLLSGRGITHQFENWWEILWLALIFGLVNALVRPVVIAMSCPLLILTLGLGTLLINTLMFVIAGWIGTQFGVGFEVDGFMPAFLGALIVSVVSALLSLFFHDEPRKHRPRPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y4</accession>
    <name>E8N0Y4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative beta-ketoadipyl CoA thiolase</fullName>
            <ecNumber evidence="7">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_04950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04950"/>
    <dbReference type="EnsemblBacteria" id="BAJ62529">
        <property type="protein sequence ID" value="BAJ62529"/>
        <property type="gene ID" value="ANT_04950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04950"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_0"/>
    <dbReference type="OMA" id="EPMRPGT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="282"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="411" mass="43389" checksum="F6BA09947A2BC1DF" modified="2011-04-05" version="1">MYNQSMVEEAVIIEAVRTPIGALGGSLARVRPDDLAAHVLQALLERTQIDPALVEEVMLGCANQAGEDNRNVARMALLLAGFPVEVAGVTVNRLCASGLSAVNMAARAIRLGEGDVFIAGGVESMSRAPYSLPKAETGFPFGNLTAYDTALGWRYPNPRMQALYGTESMGETAENIAEMTGITRQEQDAFALASHQRAIAAIDSGKFAEEIVPVPVPQKKGDPLMVDTDERPRRDTTLESLAKLKPAFRPNGTVTAGNSSGLNDGAAALLLMSASRAAQLGLKPLARIVSSAVAGVPPRIMGMGPVPAARKALARAGLTLEQIVLVEINEAFAVQTLAVMRELGLPHDKVNVNGGAIALGHPLGCSGARILTTLIHEMRRRAPYMPRPFYGLATLCVGVGQGEATIVEWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N136</accession>
    <name>E8N136_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561127.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64779">
        <property type="protein sequence ID" value="BAJ64779"/>
        <property type="gene ID" value="ANT_27530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27530"/>
    <dbReference type="HOGENOM" id="CLU_1425327_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="190" mass="20576" checksum="D175A6FCC76159B4" modified="2011-04-05" version="1">MSEAYLFGWAEASSLREAWEGALKQTFARPAWLQAVHWLVEMHPEGLETIPHYLWGAGFPQAHLALHAVLRSLREGEVDLCLFLEGSAHGAAAFLLGSPQAVGRWNLPPHARLTPLGGGLPDALEVVVRQRAQAWLGEDVSAGEVLSVSPAEGLVRGILRGLAQVKQSSQPVILLSRDRWSGLATLIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N181</accession>
    <name>E8N181_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561171.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27980"/>
    <dbReference type="EnsemblBacteria" id="BAJ64824">
        <property type="protein sequence ID" value="BAJ64824"/>
        <property type="gene ID" value="ANT_27980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27980"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_0"/>
    <dbReference type="OMA" id="SHRVPWK"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="346" mass="39125" checksum="C22820E0D5398746" modified="2011-04-05" version="1">MNIYITGISGFLSINLVRYLLEKGYTHISGIDLVDFAYPERNRITFYQGDIRDREAVRRSMAGAEMVIHTAAALPLYPPEEIYTTDVVGTRILLEEAHAMGVKRFIHISSTAVYGVPDHHPLYEDDPLIGVGPYGKAKIEAEEVCLEYRQKGMCVPILRPKSFIGPERLGVFAIFYEWASEGKNFPMIGSGNNRYQLLDVEDLCEAIHACMTLDAEKVNDTFNIGAAEFTTMRQDYQAVLDEAGFGKRIIPFPAGPVILALKVLEALNLSPLYPWIYETASKDSFVSIEKAQRVLNFQPKYSNRDALLRNYRWYLANKDALAQSGEGVTHRVPWKQKALKLVKIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N187</accession>
    <name>E8N187_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Basic membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_28040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561177.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28040"/>
    <dbReference type="EnsemblBacteria" id="BAJ64830">
        <property type="protein sequence ID" value="BAJ64830"/>
        <property type="gene ID" value="ANT_28040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28040"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_0_0"/>
    <dbReference type="OMA" id="LASMMKR"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225209" evidence="3">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="39"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="37283" checksum="834CE09B035C781A" modified="2011-04-05" version="1">MKKFSLVLALVLVLSLVLSACTTPQATATQAPEKKLICQVTDTGGIDDKSFNATAWKGALRAQDELGFEAKYLESKEVADYEKNLNAFIEEKCDLIVTVGFLLGDATKAAAEANPDFKFSIVDFSYDPPISNVVGQVFATDEAAFLAGYLAAGMTKTGKVGTFGGLPIPPVTIFMDGFVRGVKYYNQVKGTSVEVLGYDLAAPDKGLFTNSFDDQTKGKEFGITLMDEGADIIMPVAGPVGLGTAAAVKERGNALIIGVDSDWFLTAEGYQDIILTSVLKNMDATTLEVAKQVKDGAFKGGTNVVGTLANNGVGIAPFHNLDSKVPAELKAEIEQLKKDIIDGKIKLADIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N192</accession>
    <name>E8N192_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561182.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64835">
        <property type="protein sequence ID" value="BAJ64835"/>
        <property type="gene ID" value="ANT_28090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28090"/>
    <dbReference type="HOGENOM" id="CLU_562188_0_0_0"/>
    <dbReference type="OrthoDB" id="2116584at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="485" mass="54467" checksum="4B59649808EB36DE" modified="2011-04-05" version="1">MQQRGWFYRWILLGFALIFPMLACSLPTSQQGTLLSSQTDIPLDPVFVEFYQNLGGRAVLGRVLSAPFDDGQKRYQYVEAGLVAYDPTQMEPGKRIRFEPLGLELQVHDDTDIPVIHDETHDLLVEGYWVYSEFVETYKRLSLFAGSPLTHVRFNHQYARYEQFFENLGFYRELKDAPGTVRLLPYGAYLCGVGCSQRSQEYWNIVQNGLIMQPFERFVNAQKWEALGKPLAAPTITPEGMLEQVYENAILYAPVDRPADIAMRPLTLWLGKVSPQTPYPYREQAGTVFYPVEDHLGFLVPQEVDALIVRLGGVRNSGKPLGDAQQVSGEGVYRQCFENYCVDYQPTAPAGQRVRLVPQGVEYAQRLADQLTLPRAFTPETVNLLVSEAYPQVSDSDHQVLQMNVFYRQSGEPMYLVSGTATVTLPGRTLTLSLPPTNRNGASSVTLPPLKGVSNLSVIEYQICLELPSPAPICQSDTFVVFNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1B4</accession>
    <name>E8N1B4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydroorotate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_28310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561203.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64857">
        <property type="protein sequence ID" value="BAJ64857"/>
        <property type="gene ID" value="ANT_28310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28310"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_4_0_0"/>
    <dbReference type="OMA" id="LCSIVCP"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="4">
        <location>
            <begin position="88"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="335" mass="36831" checksum="0FB51A877D57AC46" modified="2011-04-05" version="1">MANLTATYLGLTLKNPVVASASPLSKKLEGIRRLEEAGASAVVMYSLFEEQITHESLALDHFLNRGTESFAEALSYFPDLENYNIGPEEYLNLIRRAKEAVSIPIIGSLNGVSAGGWVEYARKIEEAGADALELNMYYIPTDTDITAQELEQNYVDLVSEVCSRVSIPVAVKLSPFFTALPNLARRLAGAGAKGLVLFNRFIQPDLDIETLEVTPALQLSTPAELRLPLRWVAILYGRVPCDLALTSGVHDAQAVLKAMMAGAKVTMLASELIQNGLKRIGEILTDMNAWMETFEYESVSQMQGSMSQKAVAEPAAFERANYLKALQTFDNRKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G3</accession>
    <name>E8N1G3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561251.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28800"/>
    <dbReference type="EnsemblBacteria" id="BAJ64906">
        <property type="protein sequence ID" value="BAJ64906"/>
        <property type="gene ID" value="ANT_28800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28800"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_0"/>
    <dbReference type="OMA" id="PSLYAMM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="263"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="387" mass="40497" checksum="6F40159432265DE3" modified="2011-04-05" version="1">MSDVVIAGVGQIPVGEHWDVSLRSQAVRAVLAAIKDAGGLKPQAMYIGNLLAPTVSHQSNLGALLPDWSNLTGIEGITVEAAGASGGGAFRLGYLAVASGFVDTAVVVGVEKITDVVGPELERAIAESTDYDYELAQGLTLTAQAGLVMQLYLHQYKPPREAFAAFPMLAHENAVGNPFAMYRKPISQKAYDSAPMVSEPVNLMDMAPYADGAAAVVLTRRDLVPDSVSHPLVKVSGSSVASDTLALHDRSDPLAFDAARLSVEGACRQAGILPQDVDFFELTDAFSIYAVLSLEAAGFAPRGEGWKLGLDGTLRRDGKLPILTMGGFKARGNPLGAAGVYQIVEAALQLRGEAGSNQIPNARRALVQNLGGPASTAVAHVLERVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1L0</accession>
    <name>E8N1L0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxaloacetate decarboxylase gamma chain</fullName>
            <ecNumber evidence="5">7.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mmdD</name>
        <name evidence="6" type="ordered locus">ANT_05810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:57724"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="EC" id="7.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OadG family.</text>
    </comment>
    <dbReference type="EC" id="7.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559010.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05810"/>
    <dbReference type="EnsemblBacteria" id="BAJ62615">
        <property type="protein sequence ID" value="BAJ62615"/>
        <property type="gene ID" value="ANT_05810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05810"/>
    <dbReference type="HOGENOM" id="CLU_2103910_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015451">
        <property type="term" value="F:decarboxylation-driven active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005899">
        <property type="entry name" value="Na_pump_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04277">
        <property type="entry name" value="OAD_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01195">
        <property type="entry name" value="oadG_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="115" mass="12939" checksum="FC990BFE0E49D5DB" modified="2011-04-05" version="1">MNGDFLQGLTVSVLGILITFIALGVFILIMIVLQRLFPYREEEEEQAEVAQIETSQPAEETAMSQEGEIVAAIAAAVAYLRLRANPQLGNAFQEGRGRWWFSRRLEAIEGKTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1L1</accession>
    <name>E8N1L1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methylmalonyl-CoA decarboxylase gamma-subunit</fullName>
            <ecNumber evidence="4">4.1.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mmdC</name>
        <name evidence="4" type="ordered locus">ANT_05820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.41" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559011.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05820"/>
    <dbReference type="EnsemblBacteria" id="BAJ62616">
        <property type="protein sequence ID" value="BAJ62616"/>
        <property type="gene ID" value="ANT_05820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05820"/>
    <dbReference type="eggNOG" id="COG4770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_5_1_0"/>
    <dbReference type="OMA" id="AMKMNTI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="15741" checksum="41948C9AC89B5DF1" modified="2011-04-05" version="1">MKKIKVIVNEKPYEVEVGDMSISPFTVVVNGQSYQVTLEGEQVQEVRPVASAPAAPAPRPVAPAPVPAPAPKPAAAPAASGDVLTAPMPGVILDIAVKPGDKVTVGQQLCALEAMKMKNAIRSPREGTIASVEVQDGQRVNYGEVLFRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M1</accession>
    <name>E8N1M1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpC</name>
        <name evidence="10" type="ordered locus">ANT_05920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559021.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05920"/>
    <dbReference type="EnsemblBacteria" id="BAJ62626">
        <property type="protein sequence ID" value="BAJ62626"/>
        <property type="gene ID" value="ANT_05920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05920"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_0_0_0"/>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="264" mass="28868" checksum="F75701E8D8E02154" modified="2011-04-05" version="1">MNRLETILAHKQREIEERLQTVSPEQLERDIQETLPPPDFREALRRPPGAPVRLIAEIKRASPSRGQMAPIANPIELAHCYQQNGAAAISVLTDARFFSGSLEDLRAIAALPHHPPLLRKDFILHPIQILEARAAGASAVLLIAACLSPASLRHLMAYAAELGMSALVEVHNEAELEQVLTCQPEIIGINNRNLRTFEVDPYTALRLLPLIPSPMIKVAESGIHTPEDAHRFADAGFDALLVGEALVTAANPGEKMKELIGVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W3</accession>
    <name>E8N1W3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaB</name>
        <name evidence="14" type="ordered locus">ANT_06840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559112.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06840"/>
    <dbReference type="EnsemblBacteria" id="BAJ62718">
        <property type="protein sequence ID" value="BAJ62718"/>
        <property type="gene ID" value="ANT_06840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06840"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005373_0_0_0"/>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="OrthoDB" id="1709134at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="186"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ62718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="457" mass="51935" checksum="5CAEC51BF1E2320F" modified="2011-04-05" version="1">MSDWMPEEVASTEVQGPPHSREAEEAVLGAVLIDPEAYYNLAQFLHPEDFYLVRNRWIWEAFTRLHERRIPIDFLTVQQELEQQGRLAEVGGVTYLMSLINQTPSSMNAEAYARVVEEHSLRRKMIAAANEMAQLAYDRRTSVDTLIDTAEKSIFTVSERRVRRDLQPIQTVLSEVYDRVDKLSQRSDEIMGVPTGLVDLDRLLGGLQKSDLLIVAGRPGMGKTGFMLSVMKNAAQKYKKHVAMFSLEMSNEQLVQRLIAQETGIDTQRLRTGKLNEDEWPRFIHAIEVLSETHIFLDDTPAITPMQLRTKCRRLHMEYELDLIIVDYLQLMSGDVRTDNRVQEVSYISRNLKILARELNVPVLAAAQLSRAVEQRADKRPVLSDLRESGSLEQDADVVMFIHRPDALDKDSPRANLAEIIVAKHRNGPTHGGIELVFLNNLARFENAAPAPGMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X9</accession>
    <name>E8N1X9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_29000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561271.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29000"/>
    <dbReference type="EnsemblBacteria" id="BAJ64926">
        <property type="protein sequence ID" value="BAJ64926"/>
        <property type="gene ID" value="ANT_29000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29000"/>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335240_0_0_0"/>
    <dbReference type="OMA" id="MNIRCCA"/>
    <dbReference type="OrthoDB" id="973681at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="115"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="205" mass="22024" checksum="758BA176324BEE16" modified="2011-04-05" version="1">MTFDFLLDPNIGFVLLIGGVVLAILALFMPGTGLLEIGALFALVLAGYTLANLPLNVWAVVLFFVGIIPFILALIWRGSRRGLIALLISLVMLVIGSIFAFRSPRGGSAVNPVLAVLVTGGSAGLLWFMARKSIDAAIQRPSHDYDRLVGMIGEARTDIRGQGAVYVGGEEWTATCAEYVPAGTPVRVLRRKGLFLEVEPVKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N236</accession>
    <name>E8N236_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">galE</name>
        <name evidence="9" type="ordered locus">ANT_29570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561327.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64983">
        <property type="protein sequence ID" value="BAJ64983"/>
        <property type="gene ID" value="ANT_29570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29570"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_0"/>
    <dbReference type="OMA" id="KVMTGQY"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="336" mass="37445" checksum="C1C45392B24FB135" modified="2011-04-05" version="1">MKVLVTGGAGYIGSTICSALEDYGHTPVILDSLVTGREEFTRGRIFYRGDIADAALVERVFREHPDIYATIHCAALIVVPESVEKPYEYYTENVCKSLALFHTLNRLGYGRVVFSSSASIYDVVPGFMVTEESPLKPGSPYARTKYMMEMILKDFCTAYPMKGIALRYFNPIGADPKMRSGIHVKEPSHVLGKLVDTALGKLPCFEITGTTWPTRDGTGIRDYIHVWDLALAHIQAVEQFEQVFERLGGESRYAVINLGTGRGVTVRELVTAFEKVYGKEICKVERPPRPGDVAGAYANADTARRLLGWEARLPIEQGIADALRWGEIRHTILKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N255</accession>
    <name>E8N255_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_29760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561346.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29760"/>
    <dbReference type="EnsemblBacteria" id="BAJ65002">
        <property type="protein sequence ID" value="BAJ65002"/>
        <property type="gene ID" value="ANT_29760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29760"/>
    <dbReference type="eggNOG" id="COG2746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048238_0_0_0"/>
    <dbReference type="OMA" id="NTTIHYG"/>
    <dbReference type="OrthoDB" id="1018324at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ65002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="28555" checksum="9A6A5C0444E1545A" modified="2011-04-05" version="1">MLTFRDLVQAFRGLGLSPQRPLIVHASLSSFGEEIRGGAETLLGALLTVSGRVMAPTFTYKTMLIPEAGPENNALTYGAGKDLNQMAEFFFPDMPADPLMGVLAETLRCHPQAKRSMHPILSFAGIGLDEVIAVQTLVDPLAPIGALAALDGEVVLIGVNHTANTSIHYAETLAGRQGFVRWALTPKGVWECPGFPGCSDGFDAVAPSLEDVTRRGRIAQSEVQVIPLTSLLERVRGILEDDPLALLCARTECERCDTYRRLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N289</accession>
    <name>E8N289_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561377.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30100"/>
    <dbReference type="EnsemblBacteria" id="BAJ65036">
        <property type="protein sequence ID" value="BAJ65036"/>
        <property type="gene ID" value="ANT_30100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30100"/>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499365_0_0_0"/>
    <dbReference type="OMA" id="NDWRNDV"/>
    <dbReference type="OrthoDB" id="1750498at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="545" mass="63212" checksum="CD06F51CFBCE63AB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L2</accession>
    <name>E8N2L2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559211.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07840"/>
    <dbReference type="EnsemblBacteria" id="BAJ62818">
        <property type="protein sequence ID" value="BAJ62818"/>
        <property type="gene ID" value="ANT_07840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07840"/>
    <dbReference type="eggNOG" id="COG3591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762498_0_0_0"/>
    <dbReference type="OrthoDB" id="1468733at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045430">
        <property type="entry name" value="EAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19955">
        <property type="entry name" value="EAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAD1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="361" mass="40365" checksum="6CBE2DAF6513E997" modified="2011-04-05" version="1">MSLSSKFLRELVRGLTSALSLEELDSILQQELKRSLDEFTPGRTPHEILVSLILTAEQEGWLPLLISAVRRAHPYHPALVEISRRFGLAPTVTIQHSDKAPRPASSQRLEKILRNNLPFLDPARWREQMVRIEQQVCRIEMNLNPRGTGFLIAPDWVMTAYHVVQEIHQGLIAPQQVRVRFQHLLPPHQAVPAAGEEFALAKDWLVDWSPPSPAELADTEDTLPTPQEMDYAILRLAEPAGLLPVSSALPSSPPRGWMGLPGIFPAVNEEDALIIVQHPLGAPLKFALDTQGILGWNANRTRLLYRTNTQAGSSGSPCFTLDWQLIALHQRRLNNANQGCSMESIVRLMQEHGISLPENLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z8</accession>
    <name>E8N2Z8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_31220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31220"/>
    <dbReference type="EnsemblBacteria" id="BAJ65148">
        <property type="protein sequence ID" value="BAJ65148"/>
        <property type="gene ID" value="ANT_31220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31220"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_0"/>
    <dbReference type="OMA" id="RCANTQF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="136"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="36809" checksum="4916110D1F1F7EFE" modified="2011-04-05" version="1">MLSPERPTRILLVEDDGSLLEVVRDILSDAGYHVITAANGEEALQAFRQAHPDLILSDIMMPVMDGFQLLEAVRQMEAGMLVPFIFLSARTERYDTSNARRLGADDYLFKPFSADELLTAVEARLRRREQISLFSTREAHLQTVIMLASAIEERDVTTSGHVDRVRSLALEFSDYLGWSPELKMILEIGALLHDIGKIIVPEQILNKPAPLTAEEMEVMKRHPASGARILQGVHHLAPAAPYILYHHERWDGKGYPHGLKGEEIPIEGRFLALVDAYDAMTSDRPYRKGLPRERAMQIIRENLGTQFDPDLGQRFLEMLEENVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z9</accession>
    <name>E8N2Z9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561490.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31230"/>
    <dbReference type="EnsemblBacteria" id="BAJ65149">
        <property type="protein sequence ID" value="BAJ65149"/>
        <property type="gene ID" value="ANT_31230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31230"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_0"/>
    <dbReference type="OMA" id="ATAYHDK"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="117" mass="12599" checksum="AFD6B28B81238923" modified="2011-04-05" version="1">MAKILIVDDSSYARTLLKRALEKAGHVVCEASSGMDALEQLPTCQPNLVTMDLLMPGMEGLELIGHLKAMQPSLKVIVITANIQDETRKELIQAGADAFLNKPVSPDVLVNTVSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N357</accession>
    <name>E8N357_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">nuoI</name>
        <name evidence="7" type="ordered locus">ANT_08370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559263.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08370"/>
    <dbReference type="EnsemblBacteria" id="BAJ62871">
        <property type="protein sequence ID" value="BAJ62871"/>
        <property type="gene ID" value="ANT_08370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08370"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_3_0"/>
    <dbReference type="OMA" id="VDTPHAI"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="163" mass="18430" checksum="489888DD444DDEBB" modified="2011-04-05" version="1">MFKGLLTTLKEWTGKPVTIQYPEEKRPVRTRFKGRHVLKRYENGLEKCIGCSLCAAACPADAIFVEAAENTDDERYSPGERYARVYEINMLRCIFCGFCEDACPTEAIVLGDNYELSFTDRHQSIYTKEMLLEPVPEGGKPTPQQTPPGVYVRAVPAMKDPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3D9</accession>
    <name>E8N3D9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_09190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09190"/>
    <dbReference type="EnsemblBacteria" id="BAJ62953">
        <property type="protein sequence ID" value="BAJ62953"/>
        <property type="gene ID" value="ANT_09190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09190"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1202791_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="230" mass="25733" checksum="DD4CBA437F4EC15A" modified="2011-04-05" version="1">MGTFVLLVFLGLLLSGALWRAIQVNQAGIDVLHALSHQNSGELQRFVNRWSEDPPQDCRLVWLSAMAMVGKQGVLPSHEVLHNAIRCQPEYLAALEGLAPYDVRLAEEVVRMYPRNSSALMWLAQVKERFDRAQAAELYEIVTRVDATNGLAWCRLGAQRQNEGDLSGALKAFQECCQHGDPGSNGCWRAGGILEKQGRLEEAIFWYNQSRFAEALKRARELQSQLSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E7</accession>
    <name>E8N3E7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559352.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09270"/>
    <dbReference type="EnsemblBacteria" id="BAJ62961">
        <property type="protein sequence ID" value="BAJ62961"/>
        <property type="gene ID" value="ANT_09270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09270"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_4_0"/>
    <dbReference type="OMA" id="AAYQKKW"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="263"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="520" mass="57693" checksum="F6A9D7FEDE2130F9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G2</accession>
    <name>E8N3G2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DHODB_Fe-S_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559367.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62976">
        <property type="protein sequence ID" value="BAJ62976"/>
        <property type="gene ID" value="ANT_09420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09420"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212769_0_0_0"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHODB_Fe-S_bind" evidence="1">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="228" mass="25373" checksum="83D81BDCE3B371DC" modified="2011-04-05" version="1">MTFMEAILREIRYSGTGNTARLECHRKVHFRPGQYFLGNRADDPDEILPVVLHPATFPDPMLPLAPCPSNWQAGNRILLRGPFGNGFHLPEESLRVALFDWEGLAHLLVPLMQRALSQQAAVVLYASVPPSNLPPEVEVLPLEALSESFEWCDYLAGVIHRDSLAEFYQATGWKHSLHLPAHAEVLVHTPMPCGGMGDCGVCAVLEKRDWRLACKDGPVFSLHHLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I7</accession>
    <name>E8N3I7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bidirectional hydrogenase Y subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hoxY</name>
        <name evidence="3" type="ordered locus">ANT_09670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559392.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63001">
        <property type="protein sequence ID" value="BAJ63001"/>
        <property type="gene ID" value="ANT_09670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09670"/>
    <dbReference type="eggNOG" id="COG1941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093095_0_0_0"/>
    <dbReference type="OMA" id="GCEISFL"/>
    <dbReference type="OrthoDB" id="1280734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="14"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="19918" checksum="4A059EBF8C969A25" modified="2011-04-05" version="1">MAKPKIASDWMAGCAGCHMSLLDIDERILQIAELVDIRATPITDLKEPDESGVDVGILEGGINNTANEEVAHKMRKRCKILVALGDCAVFGGVPAMRNFFKLDEVLKRAYIETESTDEEGKIPDDPELAKMTKVRAVHEVVPVDVFVPGCPPDPDVIFYVLSELAQGRIPELKDEKLHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L8</accession>
    <name>E8N3L8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 15" type="primary">rpoB</name>
        <name evidence="15" type="ordered locus">ANT_09980</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559423.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63032">
        <property type="protein sequence ID" value="BAJ63032"/>
        <property type="gene ID" value="ANT_09980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09980"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_3_0"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
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        </source>
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    <sequence length="1314" mass="147821" checksum="15C5284E14BA6FDC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="802" mass="89120" checksum="C2F120D20C2D1689" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
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        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
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    <dbReference type="OrthoDB" id="1515911at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EamA_dom"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="46"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="104"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
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            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ63109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="292" mass="32516" checksum="399188FAAF9A6F9C" modified="2011-04-05" version="1">MLELVLVSLIWAFSFGLIKVSLAGVDSNFVAFARLFVSFLVFLPFARPSKIPRNLVPHLILVGVLQYGAMYLAYLNAFKFLKAYEVALFTIFTPIYVTLIHDLLEKRWERLHWLAAVLAIVGTAIVKGLNALESDFLLGFIIVQISNLCFAFGQVYYRKILQPYPELRDHTIFFYPYLGGFALAGLATLLFTNLSTVQPTGAQWLALLYLGAVASGIGFFLWNRGARKVNAGTLAVFNDLKIPLAVVVSVVVFGEKASLPNLIVGGFIVLAALMINEYKNIPFLRRQEAVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3U8</accession>
    <name>E8N3U8_ANATU</name>
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        <submittedName>
            <fullName evidence="5">Putative cobalt ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">ANT_10780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
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            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63112">
        <property type="protein sequence ID" value="BAJ63112"/>
        <property type="gene ID" value="ANT_10780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10780"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_0"/>
    <dbReference type="OMA" id="LAYGMEQ"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030947">
        <property type="entry name" value="EcfA_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04520">
        <property type="entry name" value="ECF_ATPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="297"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="334"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="578" mass="64061" checksum="98C093F64F92D630" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N469</accession>
    <name>E8N469_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenocysteine synthase</fullName>
            <shortName evidence="5">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">selA</name>
        <name evidence="8" type="ordered locus">ANT_11990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SelA family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559621.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63233">
        <property type="protein sequence ID" value="BAJ63233"/>
        <property type="gene ID" value="ANT_11990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11990"/>
    <dbReference type="eggNOG" id="COG1921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038142_1_0_0"/>
    <dbReference type="OMA" id="GATNRTH"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Se-cys_synth_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="462" mass="50978" checksum="EED9D2F934566B49" modified="2011-04-05" version="1">MNRLREIPSVDVLLQHPRAEVLQKRFGRSLLLNGVRSVLDDTRQALLNSSESPSLSPEILLNRVESLLEQWLAPTLVPVINATGVILHTNLGRAPLSLPALRAMQETAGGYCTLEYDLERGERGSRTVHAEMLLRRITGAEAALVVNNNAAAVLLVLTALARRRGVLISRTQLVEIGGGFRVPEVMAQSGAKLIEVGTTNRVRLEDYEDALRSHHSVSLILRAHHSNFRIIGFTAEPSLKDLADLAHRYQLPLVDDLGSGALLDTSKYGLAHEPMVQESLADGADVVCFSGDKLLGGPQAGIIVGKSEWIARLKKHPLARAVRPDKLTLAALAATLVYYLKEEAEEQVPVWRMITQKPERLKERAQEWQTFLGFGEVIPSRSTVGGGSLPEETLPTFVLALNVRKPNAFLANLRKCSPPIIARIEEERVVFDPRTVLPEQDGLFLNQLSHILQNQRRKEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C8</accession>
    <name>E8N4C8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559680.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12580"/>
    <dbReference type="EnsemblBacteria" id="BAJ63292">
        <property type="protein sequence ID" value="BAJ63292"/>
        <property type="gene ID" value="ANT_12580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12580"/>
    <dbReference type="eggNOG" id="ENOG5033I38">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1568862_0_0_0"/>
    <dbReference type="OMA" id="SPLWLMY"/>
    <dbReference type="OrthoDB" id="1919167at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228658" evidence="1">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="18790" checksum="4C93F3C1998EA666" modified="2011-04-05" version="1">MNKRFLVSITLLFILSLVLSACNAQPATGIDYAQIPAGKAYADGKEIYFVHTETSDPQIAEKLTNMMKSPVLTVPSLANVPQEALAQVYVFENGIAGKGPLGFQADVFNHPPSSEGYTPLRQIVLVKWAENAKARELKSEEDIKQAEANGELTLSPTNVVVNMPFVVWGGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D6</accession>
    <name>E8N4D6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transport system kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559688.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63300">
        <property type="protein sequence ID" value="BAJ63300"/>
        <property type="gene ID" value="ANT_12660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12660"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_1_0_0"/>
    <dbReference type="OMA" id="DFICSAN"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="313" mass="33770" checksum="80B4229768F19B27" modified="2011-04-05" version="1">MDLVERALAGERLAIARLLTQVENNTLLGQEALQRLYSRTGNAHIVGLTGAPGTGKSSLANQLAKVLRSTPNAHKVAIVAVDPSSPFTGGALLGDRVRMRDLAGDPGVFVRSMASRGALGGIARATSAVVQVLDALGFGIILVETVGTGQSEVEIARLAHTVIVVDAPGLGDDVQAIKAGILEIADILVVNKADLPGVENTLRALSLMLEMIPQAQGETNWKPPLLRASAVNGEGIEEIVQAIFRHGEYLRNHSLWTTREKYRVLTEILERVQETLLEQWKHTVGEARLNEMVNNVLKREISPAEAVKRLMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E0</accession>
    <name>E8N4E0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbiQ</name>
        <name evidence="6" type="ordered locus">ANT_12700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63304">
        <property type="protein sequence ID" value="BAJ63304"/>
        <property type="gene ID" value="ANT_12700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12700"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_1_2_0"/>
    <dbReference type="OMA" id="IASFMIR"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="29497" checksum="E4EA9FC1AAB4C053" modified="2011-04-05" version="1">MHAHFLDPFKPRLSPVHQLDARLKVPLVIVFILATSLVPIGAWPFYLLLIAVLLSSEILSDLGVLFFLKRAVLALPFVLAALPVLFTQVGTVWISLPFGLAITAQGVERFISVALKAWISIQAAILLASTTPFPDILLALRAMRLPKVLVSIIGLMWRYLFVIVDETIRMMNARSSRSGASSDPSHRQGGSVVWRAKVTGGMAGNLFIRSIERSDRIYHAMLSRGYDGEIRHLPLPAIPSIQWWIFIWSLLTLVVMVVLSRVLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E9</accession>
    <name>E8N4E9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12790"/>
    <dbReference type="EnsemblBacteria" id="BAJ63313">
        <property type="protein sequence ID" value="BAJ63313"/>
        <property type="gene ID" value="ANT_12790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12790"/>
    <dbReference type="HOGENOM" id="CLU_2986460_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="57" mass="6940" checksum="E137AE8F9795EB8D" modified="2011-04-05" version="1">MTEEEAEPDSIPDLSIQGLLKKIIAWIQLRLDYYPFLKKYRKTHMYFLRKGLTFWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G5</accession>
    <name>E8N4G5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559717.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12950"/>
    <dbReference type="EnsemblBacteria" id="BAJ63329">
        <property type="protein sequence ID" value="BAJ63329"/>
        <property type="gene ID" value="ANT_12950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12950"/>
    <dbReference type="HOGENOM" id="CLU_2630398_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="77" mass="8875" checksum="1455A9AE49C25FBD" modified="2011-04-05" version="1">MKDLGLAGWCAIGFLLLVIIGFNLWLYEFFKSKGDIPEIQILKRSFQALQKPFGQEEEQISELARKVREINSSSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G9</accession>
    <name>E8N4G9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63333">
        <property type="protein sequence ID" value="BAJ63333"/>
        <property type="gene ID" value="ANT_12990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12990"/>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502216_0_0_0"/>
    <dbReference type="OMA" id="IMLNAYI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="299"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="506" mass="56492" checksum="DB91A130D194D973" modified="2011-04-05" version="1">MLSYFSGKIRSMRNRNSFLFIRWISIALIFLSAILTVTQLVRYSRIRATFLPGQTIAGVPVGGLTPQQAAERLLTVYTATPVEVRYRDSVFQIKPSTVDFRLNLEAMMTAADLERLQQPFWPGFWEFLWNRLPTPKPVPLIATFSEERLRAFLQEEIVARYDEPPKPAMPLPGSVSFQPGQAGTSLDVERAVVLIGDALRSPTSRQVNLSFNRVNAPRPSVDNLKILLQQIVELSGFKGTLEMYVNDLQSGEEIHFAYSEGKLVQPNIAFSAASTIKIPIMVSAMIRSPEPVPDDIAEQISLMIEYSENGPADRLMEMLLDRNTGPLMVTADMQTLGLENTFLAGYFYPGAPLLQRFTTPANQRTDVSTDPDLYNQTTASDIGSLLEDIYMCAEKNGGTFAALFPNQLTQTKCKQMVAYLLKNRNGVLLEAGIPEGTQIAHKHGWTIETDNLMHSVSDAGIVYTPGGNFIITIYMYDPVQLLWEPANRVVADLARAIYNYFNLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I2</accession>
    <name>E8N4I2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_13140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63346">
        <property type="protein sequence ID" value="BAJ63346"/>
        <property type="gene ID" value="ANT_13140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13140"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="OMA" id="ITYNYCM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="197" mass="23159" checksum="9D9CB8B837636D8C" modified="2011-04-05" version="1">MSHLETEWIQQAIQGNEDAFAYLVELYQRPVYNLCYRMLGNAQEAEDAAQEAFWRAYQALRRYDPQRPFITWLLSIAAHYCIDQQRKRRIPLLDLDLLPEEDIPDGAPDPARVIAERDSQEQIHQLLKKLSSLDRAAIILRYWYDFSEEEIARTLSLTVSAVKSRLFRARRELAERYQIEMEKPLVGRRANETTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J2</accession>
    <name>E8N4J2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">pgk</name>
        <name evidence="11" type="ordered locus">ANT_13240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559743.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63356">
        <property type="protein sequence ID" value="BAJ63356"/>
        <property type="gene ID" value="ANT_13240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13240"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_0"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="391" mass="41420" checksum="E41A11B943A4EE98" modified="2011-04-05" version="1">MFNKKSVRDIDVKGKKVLVRVDFNVPIKEGVVQDDTRIRAALPTIEYLLEQGAAVILFSHLGRPKGGPDPKYSMKPVAEYLAQLMGKPVAFAEDCVGEPAEKAAANLKPGEVLVLENTRFHPEEEKNDLELAKKMAALADIYVNDAFGSAHRAHSSTEGVARFLPAVAGFLMEKEIQYLSQAIENPKRPFVAILGGAKVSDKIGVIKNLLTKADTILIGGGMANTFFKAQGYPVGKSLVEDEVLDLARELIAQGGTKLRLPVDVVIAQSMEEGAETKVVPVGPIPDDWMILDIGPETVASYGKVIANAATVVWNGPMGVFEVSTFAKGTFGIADALAKSNAISIVGGGDSASAVQKSGLAEKITHISTGGGASLEMLEGLFLPGVAALLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U4</accession>
    <name>E8N4U4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NarL family two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_14300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14300"/>
    <dbReference type="EnsemblBacteria" id="BAJ63458">
        <property type="protein sequence ID" value="BAJ63458"/>
        <property type="gene ID" value="ANT_14300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14300"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="VLVFTTY"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="24635" checksum="90420AFE1D867131" modified="2011-04-05" version="1">MEVLEMPRQRILLVDDHEVVRIGLKALLEHHAQFEVIGEASTAKEAIDMVSRYHPDIVLMDIRLPGASGIEACEEITTRFPDTRVVMLTSYAEDEMLFSAIRSGASGYILKQIGGEDLIRALESVGRGEALLDPAVTQRVFQEVRRAVKEEEASAFANLSQQEKHVLLLVSEGKTNREIAKALFLGEGTVRNYVSSILSKLGVSNRAEAAAYAVEHNLREYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N525</accession>
    <name>E8N525_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative OmpR family two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_15110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63539">
        <property type="protein sequence ID" value="BAJ63539"/>
        <property type="gene ID" value="ANT_15110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15110"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_0"/>
    <dbReference type="OMA" id="AVHIRHI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="244" mass="28712" checksum="BEC34A4732086C25" modified="2011-04-05" version="1">MPEQFKNRSILVVDDEERMVRFIRLNLEHDGFQVISAYRGYEALEKVRTEMPDLVLLDVMLPDLDGFEVLKLIRESSNTPVIMLTAKGEEDDRVRGLELGADDYITKPFSPRELVSRVKAVLRRVEATSLTAKNEIIQVDDRLKIDFGRREVWVEGNLVKLRPTEYRLLYHLVQNAGWVMTYEQLLTKVWGYEYRDEEHYVRLYVNYLRQKIEEDPSNPKYILTERGVGYRFVDFRKAAESSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D6</accession>
    <name>E8N5D6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560030.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63650">
        <property type="protein sequence ID" value="BAJ63650"/>
        <property type="gene ID" value="ANT_16240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16240"/>
    <dbReference type="HOGENOM" id="CLU_1297674_0_0_0"/>
    <dbReference type="OrthoDB" id="2157765at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228187" evidence="1">
        <location>
            <begin position="24"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="212" mass="23663" checksum="A416FBE0AE88AB53" modified="2011-04-05" version="1">MIKLRTLILGVLVFLSLVGCFQADHQAEQDGVLFQDDFSEPGNDWGILNSEDGVIEYTRGGLRIFVRKPYTDLWTVAGKDFSNAEIQVQATLQNTVVNNSFGVICGYQNHNRFYMLLVSSDGYFGALKKNGENYSLIGQDQLKYNDGLLEKGSTYQLRAICKQGHLLLYVDGERLFDVQEVDDIQGKVGLIAGALSEPGVDILFDHFIVKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5F9</accession>
    <name>E8N5F9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_16470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63673">
        <property type="protein sequence ID" value="BAJ63673"/>
        <property type="gene ID" value="ANT_16470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16470"/>
    <dbReference type="eggNOG" id="COG3732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326700_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="881" mass="101559" checksum="907E2C5A84D59F81" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G1</accession>
    <name>E8N5G1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560054.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16490"/>
    <dbReference type="EnsemblBacteria" id="BAJ63675">
        <property type="protein sequence ID" value="BAJ63675"/>
        <property type="gene ID" value="ANT_16490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16490"/>
    <dbReference type="eggNOG" id="ENOG50327C4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145470_0_0_0"/>
    <dbReference type="OMA" id="DLQYWQQ"/>
    <dbReference type="OrthoDB" id="1979404at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009666">
        <property type="entry name" value="Uncharacterised_Ycf35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39638">
        <property type="entry name" value="PTHR39638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06868">
        <property type="entry name" value="DUF1257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="126" mass="14837" checksum="FA0590681833B307" modified="2011-04-05" version="1">MSHFSRIQTELMEKEYLLLALKDLGIEYQEGELTIQGFAGTTMPVEIRIPLKFSFDIGFRKGNNGYELVADWYGVRGLNRYQFLKKLKQRYAYHVTRAKLEKQGFALVEEEVKETGQIRLLLRRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5M7</accession>
    <name>E8N5M7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_17150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560120.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63741">
        <property type="protein sequence ID" value="BAJ63741"/>
        <property type="gene ID" value="ANT_17150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17150"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_0"/>
    <dbReference type="OMA" id="YEMGRQA"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228652" evidence="1">
        <location>
            <begin position="19"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="35"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="336" mass="37273" checksum="E7A745A06C411B83" modified="2011-04-05" version="1">MRLRFMLLFLLFLPGLVACQPLSTDRKDEVRTLRIAWIPKALDNPVFELGRKGAFQRAAELSATGNVKVEVIYTGSVSSDAMEQARVVEDMIARKVDAIAISCNDPIACINPINQAVDAGIPVITWDSDSPQSKRFAYLGVNNVEGGKQAAKLLIEAMGESGKIAILTGVPGAYNLEERIRGFREVIDQYPDIKVVAVRSTNDDINLSVQVVEETMQAFPDLNGWFFVGMWPLLAGRGSMPLWEQAALKGNLKTVSWDTMPEELEFLKDGYLSGLIDQNCWAWGYDTIQILYDKLIYGKSTPDFIDAGLRVVTQKEVEAMMRLWETGEFPSPGGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5M8</accession>
    <name>E8N5M8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_17160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560121.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17160"/>
    <dbReference type="EnsemblBacteria" id="BAJ63742">
        <property type="protein sequence ID" value="BAJ63742"/>
        <property type="gene ID" value="ANT_17160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17160"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_2_2_0"/>
    <dbReference type="OMA" id="LAVWMDT"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="278" mass="28978" checksum="562B68BA976557C4" modified="2011-04-05" version="1">MRNFAWIALAALGQSMVIITGGIDLSVGAVMALSSVVTAFSLRAGFPVWLSIFFGIAVGAAIGLINGFFVAKVRLPAFIATLITMSISRGLVFGWTRGWPVRDFPDSFRALGFDLALGNFLLPISLVVTFVLALLVAFVMNNTVLGTYIFALGNSERAVVVAGVDHVRVKTLVYVMSGMLAAVSGLLLTARLGVAAPTAAEGYELSIIAAAVIGGASLFGGEGGVTGVLLGAAFVQVLNNALVLLGVAANWQTAVIGVATLIALLADYFRRRKILQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N3</accession>
    <name>E8N5N3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_17210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560125.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17210"/>
    <dbReference type="EnsemblBacteria" id="BAJ63747">
        <property type="protein sequence ID" value="BAJ63747"/>
        <property type="gene ID" value="ANT_17210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17210"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_1_1_0"/>
    <dbReference type="OMA" id="MCFKQYW"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027604">
        <property type="entry name" value="W_rSAM_matur"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00570">
        <property type="entry name" value="tungsten_cofactor_oxidoreducas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04317">
        <property type="entry name" value="W_rSAM_matur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="45"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="395" mass="45179" checksum="1E35B2E8EB5A72C3" modified="2011-04-05" version="1">MPKLIADSEGRLQLPFSFLERRQMPAGAEYWLDERDGDLILHPRKPDVRKLYIEPTTGCNLHCVTCIRNVWEDEEAQMSMQTFERILEGIDHLPELKRVVFTGFGEPLTHKNIFDMIEEIRRRGIAVTVGTNGLLLNEDKARMLVEAGVDRLVVSVDGVKPETYSSVRGAMLAQVLENIRRVNRIKSELSTVIPALGIEFVALKSNVEELPHLAGLASHLNAARILVTNVLPYTEEMREEVLYGYGPQAPLKGGSWPVRVSGWVMWGTLDMPRMHWGAERRCRFVYDRATVVGWDGGVSPCYAFSHNYHYYAVDGLRKKVTRYLLGNVNETPLEEIWMSEEYVRFRSEVMGFHFPSCPDCDLRETCDLRQRNEGCWGWNPSCADCLWAQDIVRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N5</accession>
    <name>E8N5N5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17230"/>
    <dbReference type="EnsemblBacteria" id="BAJ63749">
        <property type="protein sequence ID" value="BAJ63749"/>
        <property type="gene ID" value="ANT_17230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17230"/>
    <dbReference type="HOGENOM" id="CLU_2679642_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="74" mass="8875" checksum="D9F494927E9D8B54" modified="2011-04-05" version="1">MVSFEKFGVNQRFPEKGNERKLLIERGSFVIFFKEVWQRTFCRFFPRHFSIPFDKGGTDYVDSQNQYDGPQCQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U8</accession>
    <name>E8N5U8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hypF</name>
        <name evidence="12" type="ordered locus">ANT_17860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560190.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63812">
        <property type="protein sequence ID" value="BAJ63812"/>
        <property type="gene ID" value="ANT_17860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17860"/>
    <dbReference type="eggNOG" id="COG0068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009164_0_0_0"/>
    <dbReference type="OMA" id="VQHHYAH"/>
    <dbReference type="OrthoDB" id="48295at2"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="204"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="765" mass="85974" checksum="C99587596631D794" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5X2</accession>
    <name>E8N5X2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rocD</name>
        <name evidence="7" type="ordered locus">ANT_18100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560214.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18100"/>
    <dbReference type="EnsemblBacteria" id="BAJ63836">
        <property type="protein sequence ID" value="BAJ63836"/>
        <property type="gene ID" value="ANT_18100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18100"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_0"/>
    <dbReference type="OMA" id="DVFPRFA"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="400" mass="43905" checksum="FE5AAA524EC5A4D2" modified="2011-04-05" version="1">MKSEYFIELEEKHGAHNYHPLDVVIERAQGVWVYDVEGNQYLDCLSAYSALNQGHVHPKILQAMIEQASRVTLTSRAFRNDQLPLLYKELSELTGYDMSLPMNSGAEAVETAVKLARKWAYEVKKVPKYEAEIIVASGNFHGRTTTIISFSTEPAYKEPFGPFTPGFVVVPYGDADALEKAITPNTAAVLLEPIQGEAGVIIPPAGYLKKVAEICQRNQVLFIADEIQTGLGRTGKLFASHHENVRPDMVVIGKALSGGFYPVSAVLADEPLMGLFQPGEHGSTFGGNPLAAAIARAAIRVLQEENLIENAAVQGEYFIEQLAEIPSKHIKEVRGKGLLIGVELKPEAGGARRFCEALKEQGILAKETHMHVIRFAPPLIIDRATIDWALPKIREVLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5X8</accession>
    <name>E8N5X8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_18160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560219.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18160"/>
    <dbReference type="EnsemblBacteria" id="BAJ63842">
        <property type="protein sequence ID" value="BAJ63842"/>
        <property type="gene ID" value="ANT_18160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18160"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187968_0_0_0"/>
    <dbReference type="OMA" id="WRYHERI"/>
    <dbReference type="OrthoDB" id="1838234at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="FCD" evidence="5">
        <location>
            <begin position="97"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="233" mass="26821" checksum="9CC945B0AE76CDC5" modified="2011-04-05" version="1">MASPEHQNLSFLSPFLQYLAEVGKKGDSLPPLTTISEHLGISLASLREQLEVARALGLVEVRPRVGVRVLPYSLKPALLQSAGFAIQMDETHFAQFSDLRKQVEAGFWYQGVLSMSPADRHSLLSLVERAEEKLRRNPPQLPHEEHRELHLSMYRKLNNPFVLGILEAYWDLYEAIGLAYYTDMNYLCRVWDYHRRMVEAILNENLDLGFQLLMEHAGLLTQRQHPDIAPRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y8</accession>
    <name>E8N5Y8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ordered locus">ANT_18260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560229.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18260"/>
    <dbReference type="EnsemblBacteria" id="BAJ63852">
        <property type="protein sequence ID" value="BAJ63852"/>
        <property type="gene ID" value="ANT_18260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18260"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_0"/>
    <dbReference type="OMA" id="TMDWMAV"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="18"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="186" mass="21660" checksum="918A653590DCE88B" modified="2011-04-05" version="1">MERDFWLDDVQEVLFTEEQIHERVKELARQISQDYQEKTPIIVGVLKGVMCFLPDLIRKMSIPVEVDFIAVSSYSTETRDKGVVRVVKDLDLPLMDRHVLFVEDVVDTGLTLHYLLRNLRARNPASLEVCTLLNKNPRRLINIPIRYVGFEVPDYFVVGYGLDYNERYRNLPYIGILKPSVLFGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N621</accession>
    <name>E8N621_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">zwf</name>
        <name evidence="9" type="ordered locus">ANT_18590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560262.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18590"/>
    <dbReference type="EnsemblBacteria" id="BAJ63885">
        <property type="protein sequence ID" value="BAJ63885"/>
        <property type="gene ID" value="ANT_18590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18590"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_0_0"/>
    <dbReference type="OMA" id="VEICVYE"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:NADP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="196"/>
            <end position="495"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="155"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <ligand>
            <name>substrate</name>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="5">
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            <position position="223"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00022526"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ63885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="498" mass="57223" checksum="0EF2479C027A8911" modified="2011-04-05" version="1">MTSSEAFISTEPVAFVIFGITGDLAHRKLLPALYELFRENRFQAPFYLIGFARRDWTDDFMKQSMREAIHQFARTRPVDDEVIHRLLENARYIRSSFDEDEGYQKLYSVVHELGACNVLHYLATPPDAYLAILERIGKYHMAQCQGAWTRLVIEKPYGRDLESALELEEVVHRVFSEDQVFRIDHYLGKETVQNILVFRFANGIFEPLWNRNYVDNVQITVAETVGVGSRAGYYDSAGVIRDMFQNHLLQLIGLTAMEAPVAFNADAVRDEKLKVLEALRPMRGRDAILNTVRAQYVAGVVDGQRVPGYKDEKGVPPDSLTETFLAARIFIDNWRWAGVPFYVRSGKRLPARVTEIAIQFKQPPLRLFNWQSMTEDAPNMLILSLQPNEGITLTFGAKAPKPRMMIAPVKMNFSYQEAFGTEPPEAYERLILDCLMGDATLFTRSDEVLAAWRFTSDILKAWKEYPIRNLPIYEAGTWGPPMVDEFIQKDGWHWRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N678</accession>
    <name>E8N678_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">ANT_19160</name>
    </gene>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Anaerolineae</taxon>
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            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ63942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
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    <dbReference type="STRING" id="926569.ANT_19160"/>
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        <property type="protein sequence ID" value="BAJ63942"/>
        <property type="gene ID" value="ANT_19160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19160"/>
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    <dbReference type="OrthoDB" id="2218756at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="430" mass="49376" checksum="EE69BE685C6529C9" modified="2011-04-05" version="1">MNQTRPQRSYQVQHRISGLLRIFALFLLIIVFLFFAGMFFEPELKEMVQNFWNAPLVEFFRIALNPHTARYMITALSVLVFVTLAAGSYVRDIYALPRLRQGVRYVISSLFALFVPRIIVDGGEKKLEKNEVNLIDVIGGPGHVIIQPGNAVMFKELRRPSTISIRESYYLRPFETIGQIVNLDEQQDSRSDIPAISRDGIRLTIRDIQFRYRLFPELQYGRPKKRTIDDPYPFDERALWNSAYNLPVTDSGPDSWKTVVGRAVVGGITDFISEHDIDYLTAPREAGIDPRREIRYSLLHGPTKNSLRNNGAELVWVDIGHFEIDPAVDEQRTDYWAADWLGNAQVQRAYGEAKRQMFLEMGRAEAHAEMVIALTEALKDVNWGQEPAETIRKLLVLKTAEIIENWVNSRQKPGNNQDQKTSFFEDILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A6</accession>
    <name>E8N6A6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19440"/>
    <dbReference type="EnsemblBacteria" id="BAJ63970">
        <property type="protein sequence ID" value="BAJ63970"/>
        <property type="gene ID" value="ANT_19440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19440"/>
    <dbReference type="HOGENOM" id="CLU_3228872_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="43" mass="4867" checksum="5CBA42E1CC581EF6" modified="2011-04-05" version="1">MFRIRGVPETYIIDASGKLAYIKIGPFDSTREIIDVIEPLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B1</accession>
    <name>E8N6B1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_19490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560348.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19490"/>
    <dbReference type="EnsemblBacteria" id="BAJ63975">
        <property type="protein sequence ID" value="BAJ63975"/>
        <property type="gene ID" value="ANT_19490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19490"/>
    <dbReference type="eggNOG" id="COG2332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079503_3_2_0"/>
    <dbReference type="OMA" id="KTLMTKC"/>
    <dbReference type="OrthoDB" id="1724595at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017003">
        <property type="term" value="P:protein-heme linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004329">
        <property type="entry name" value="CcmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036127">
        <property type="entry name" value="CcmE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03100">
        <property type="entry name" value="CcmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82093">
        <property type="entry name" value="SSF82093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="183" mass="19911" checksum="7E52C4A398414AB4" modified="2011-04-05" version="1">MDLAHQPQVEQSMSLQRSSTNKWKFIVGGLLIIAAVVYLIVSSATANAQYFMTVEEVQQRGASVVGRELRVSGAVIGESIQYDPQTLRLEFVVAHTPGSQKEVDAQGGMAAVLHAAVLDPNRPRLKVVYLGVKPDLLTNEAQAIMTGRLGEDGVFYAEELLLKCPTRYEEALPGQAENSRNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH8</accession>
    <name>E8MXH8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20330"/>
    <dbReference type="EnsemblBacteria" id="BAJ64059">
        <property type="protein sequence ID" value="BAJ64059"/>
        <property type="gene ID" value="ANT_20330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20330"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728898_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="384" mass="44231" checksum="20AAD332F4F42516" modified="2011-04-05" version="1">MESKREALRFLRILRGDVPNTSRRGWNIHLEGALSWLNLAIASTGGIGLSKGFDLLRRKWHPLYPEITGYTIPTLLNLYLMTGNSRWEALALKWAKNLLQYRSIEGGIYYWDHQKSHYPVIFDTGQVIFGWVAAYCHTGNPLFLEAAEQSANWLVHQQREDGVWVNHQHLNYPKVIDARVDWALLELYKVRPKPVYQQAALRNLNWVLQNQHPDGWFSHCGFRRFEAPFTHTLAYTAEALFYSAKITDDERFMEAAQKTAEALMHFQRPDGSLAGAFGKHWKEAEKSTCLTGNAQISKLWIEMSKEFHTSEYKVAAEKSLEFLCKTQILGTNFCEILGGIAGSYPIYGKYERFKYPAWACKFFIDALLAVQKDNATRELLFYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI4</accession>
    <name>E8MXI4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20390"/>
    <dbReference type="EnsemblBacteria" id="BAJ64065">
        <property type="protein sequence ID" value="BAJ64065"/>
        <property type="gene ID" value="ANT_20390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20390"/>
    <dbReference type="eggNOG" id="ENOG5033SWM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_551934_0_0_0"/>
    <dbReference type="OMA" id="CFAKYYV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228440" evidence="1">
        <location>
            <begin position="26"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="497" mass="55671" checksum="62C21BAD0E212E17" modified="2011-04-05" version="1">MIRRMKNILLIFLLVQLLASCAAHPLPEDSKGVYESVPPSNTNAPEQTPFSVFLPTVIRPEESRYRINARYLPDETWLVPSSIFWFGKVTRSENYVDVRTGYGDQNLKLHFEVFDRMLWYDTSPTTAELSQYDAIGVYLKTSGANGNTPDSQSYLFIVQSHPNYLDKSQYMASFRWNGQEWTKSTIPFNIRLAYAGEGGYNQTSKDNRGWFIEMSIPYTSMGFSQNPVAGTTWGLAVVLYDRDDASSSLPAKQWPPNANLSIPATWGTLGFGLPTYSAPPSINQNTMVIREGWNASKVPDASVGGSTVCGEGTDFFGTWGDTPESFYANRTVNNTQFNIQNQMDVADWPCFAKYYITFPLDALPKGKVIVSAKLVLHHFGNSGAPGEAEDSLIHVMLAERDWDERTLTWNNAPLALENFAATYVPPLLSYPGDMGVRREWVITPALVRAYQKGEPLRLVLYSSDSARHSGKYFWASNRPDLEASRPALEIIYGDPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ2</accession>
    <name>E8MXJ2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20470"/>
    <dbReference type="EnsemblBacteria" id="BAJ64073">
        <property type="protein sequence ID" value="BAJ64073"/>
        <property type="gene ID" value="ANT_20470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20470"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105320_5_0_0"/>
    <dbReference type="OMA" id="LDRGKDM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="116" mass="12596" checksum="C26C4FE5CA3380D8" modified="2011-04-05" version="1">MQNARKELNMSDRDEFGAFLIGFVVGAVTGAVVSLLFAPQSGEETRVLIKERAIELADKASETAQTISKEVETRTEEYLSKAEELAKKGQAVLEEQKAKVTEAVQSVAKPKGETPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL7</accession>
    <name>E8MXL7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_20720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560468.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20720"/>
    <dbReference type="EnsemblBacteria" id="BAJ64098">
        <property type="protein sequence ID" value="BAJ64098"/>
        <property type="gene ID" value="ANT_20720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20720"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="OMA" id="PRNMYDK"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="41643" checksum="CEF7C84C7921C2B0" modified="2011-04-05" version="1">MASVTFDHVTKKFGDVVALNDLNIKVEDREFLVLVGPSGCGKTTALRCLAGLEEVTSGRILIGDQVVNDIPPKDRDIAMVFQSYALYPHMTVFDNMAFGLKLRKFPKDEIKRRVEEAAQILGIETLLKRKPRELSGGQRQRVAVGRAIVREPKVFLFDEPLSNLDAKLRVQTRAEISKLHQRLQTTFIYVTHDQVEAMTMATRIAVMNKGVLQQLDTPQNLYDRPANLFVAGFIGSPAMNFFPARLHKEQGELIIDTGDFAVKIPAEKRDLYAPYVDRQVIFGIRPEDIHNPMYAPPGIHAAPVESKVDVIELMGNEIFLYMVSGKNNYVARVDPRTRFKIGETVQLVFNMDNIHLFNPAADSENPPAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM4</accession>
    <name>E8MXM4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560475.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64105">
        <property type="protein sequence ID" value="BAJ64105"/>
        <property type="gene ID" value="ANT_20790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20790"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065947_2_2_0"/>
    <dbReference type="OMA" id="RLNWRLM"/>
    <dbReference type="OrthoDB" id="1301886at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="12"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="26495" checksum="EA269CF739C88B43" modified="2011-04-05" version="1">MEAVQVVRSRRKTIAIEIHPDGRVILRLPLRYPKTKIPEILEQYRDWITEKVRKFQEQQRQIPEHKFVEGETFLYLGKEYPLHILEHASRALEWNEAGFWMLKTDSHHARKLFLAWYQEKALAYFTARAKHFDKKFTDKPYQIKLSNARTRWGTCSTRGILRLSWRIIMAPPEIVDNVIVHELAHFLHQNHSRAFWEAVAAECPNYKQARAWLRNFGHLLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN0</accession>
    <name>E8MXN0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20850"/>
    <dbReference type="EnsemblBacteria" id="BAJ64111">
        <property type="protein sequence ID" value="BAJ64111"/>
        <property type="gene ID" value="ANT_20850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20850"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_580939_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="295"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="470" mass="52045" checksum="990783AD7EDA75D3" modified="2011-04-05" version="1">MSTSENVRAYFNQNAFRWDTLRTEYFPDTLREVILSKAYLRPEMVVADIGGGTGFVTLGLATRVNQVHLVEPSSAMLEIAKKNLSAFTNIIYHQTGVENLPFPEESLDAMFANMVLHHLPDPEQGIKEMVRVLRPGGRLILTDLDNHSYTWFKEEMADVWLGFDRQEIRKWFEQTGLVNVLVTDTKDSCCTKETCQCSCESSSKEAQISIFLATGTRKYISMEKVTEAYSDIAIMERPCCAPSSETGNSSCCCTKPQAFLISADYAEEDLIQVPEDLWQNSLGCGNPTAFARLQPGMTVLDIGSGRGLDVFLAAQKVGKEGRIIGIDPSPEMLKKAQQIAEKYQLANVEFRQGEAEEIPLPDETVDVILSNCVVNLSEDKSKAFQEAFRVLKSGGRLNISDIVLSTSLPMEIQLDETGWVSCISGSLPEQEYLDLLQQAGFSEIAIEKKVPAGQIAGTEIFSLTLTATKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR7</accession>
    <name>E8MXR7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560518.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64148">
        <property type="protein sequence ID" value="BAJ64148"/>
        <property type="gene ID" value="ANT_21220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21220"/>
    <dbReference type="eggNOG" id="COG4422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054184_0_1_0"/>
    <dbReference type="OMA" id="NPWEGCQ"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011101">
        <property type="entry name" value="DUF5131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07505">
        <property type="entry name" value="DUF5131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="240" mass="28087" checksum="43296B7CC72681F9" modified="2011-04-05" version="1">MSAKSLIEWTESTWNPLTGCNKISPGCKYCYAERLAIRLKAMGQEKYQNGFRLTLHPEVLEEPLSWHKPQIIFVNSMSDLFHENVPIEFIQRIFDVMSRAHWHTFQILTKRAERLLQLDPILEWPENVWMGVSVENENYTYRIAHLQKSRAKTKFLSLEPLLGPIPNLELEKIDWVIVGGESGPHARPIKIEWVRDIRDQCLAKNVPFFFKQWGGTNKKRTGRLLDGQIWNQMPILFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV0</accession>
    <name>E8MXV0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64181">
        <property type="protein sequence ID" value="BAJ64181"/>
        <property type="gene ID" value="ANT_21550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21550"/>
    <dbReference type="HOGENOM" id="CLU_1131755_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003227940" evidence="1">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="28351" checksum="EED9F09CF52D067C" modified="2011-04-05" version="1">MKMRKTILFMLLLVFLAGCSLRATPTPTATPRPTSTPTEEVRYYPKLDASMRQELLYRVAKPKQYYREVVLPDGMKYEAFWLMVISSGKTETLKTGQYDLDVVWVYERNLDTAYYPLVVGVWDGEIYTPYYTGYTGAPERQAYLMFLEEKGVLERGRKLFPSVADQSGGYVSLHKQIEWDRCGDSTYCHLGRYMQETYRMDRKVIGQYAGLDPIPEGWALAWMWDAAMENYLPSEQKIDLPQGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX7</accession>
    <name>E8MXX7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_21820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560578.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21820"/>
    <dbReference type="EnsemblBacteria" id="BAJ64208">
        <property type="protein sequence ID" value="BAJ64208"/>
        <property type="gene ID" value="ANT_21820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21820"/>
    <dbReference type="HOGENOM" id="CLU_1648622_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228453" evidence="3">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="160" mass="17339" checksum="7A66DA11B902471F" modified="2011-04-05" version="1">MAVFLILLAFLGILAIAVAVSMSAHADALQAQAAIEAARAAQIAAAGQAVNSALLTALVVATGFTLLAVLIVLAYLVYTRQKQQRTGKWLPGPNARWGRVDDAPRPVALPQGDPLQQLVQLELLRYLRQMNTSPVRPSLPQREAAYLPHPEEDEDDEPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX8</accession>
    <name>E8MXX8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xre family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560579.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64209">
        <property type="protein sequence ID" value="BAJ64209"/>
        <property type="gene ID" value="ANT_21830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21830"/>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2713554_0_0_0"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="72" mass="8419" checksum="F3C078CBDBEEB2F7" modified="2011-04-05" version="1">MNGQAIIEQLETRRKELGMTDEAFARLLGISRPLWSQLRSGRRRLTLAVLRRILRTFPDWEEAVLALLREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY3</accession>
    <name>E8MXY3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssb</name>
        <name evidence="5" type="ordered locus">ANT_21880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560584.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21880"/>
    <dbReference type="EnsemblBacteria" id="BAJ64214">
        <property type="protein sequence ID" value="BAJ64214"/>
        <property type="gene ID" value="ANT_21880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21880"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_2_3_0"/>
    <dbReference type="OMA" id="DCAYWIS"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="113" mass="12343" checksum="E7500F2F4840BC38" modified="2011-04-05" version="1">MLEIQLIGNLGKDPEARYTNEGVLVVNFPVAVSTRKDETVWVEVTAWRELGERCHQYLAKGRQVFVRGIPTIEAFTRKNGEAGAALKVTAQVVQFLGGGKGEAGEDHGGEMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY7</accession>
    <name>E8MXY7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560587.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64218">
        <property type="protein sequence ID" value="BAJ64218"/>
        <property type="gene ID" value="ANT_21920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21920"/>
    <dbReference type="HOGENOM" id="CLU_1923198_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="131" mass="14844" checksum="F5DE952B5D9DA828" modified="2011-04-05" version="1">MIRPKYVIVCDYGIYDHWRKRHSAIGIFDYFSAGNFPARIRFDIVCGWEADEGESEGDFSVKVTAVTGSEGDRRIVAETNRVSAIFDPFSHTAPNTFHFDIDVPTAGNYQFEFYFNGNLVHTLAVPVIPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY00</accession>
    <name>E8MY00_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase (Ubiquinone), 20 kDa subunit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560600.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64231">
        <property type="protein sequence ID" value="BAJ64231"/>
        <property type="gene ID" value="ANT_22050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22050"/>
    <dbReference type="eggNOG" id="COG3260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_0"/>
    <dbReference type="OMA" id="WNPREAD"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="36"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="19302" checksum="1BD32169E1FFCF73" modified="2011-04-05" version="1">MTEQTLRSPWQEVLDKVRLWARVNSPWAIHYNSGSCNGCDIEIVATLTPRYDLERFGVKLEGSPRHADVLICTGPVTRQSRDRLLRIYHQMPEPKFVVAVGSCGLSGGVFHGLYNIAGGIDEVLPVDVFIPGCPPRPEAIIYGLVQLLEGLRGREPSPEVKEMLRQAAKEERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY13</accession>
    <name>E8MY13_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_22180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560613.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22180"/>
    <dbReference type="EnsemblBacteria" id="BAJ64244">
        <property type="protein sequence ID" value="BAJ64244"/>
        <property type="gene ID" value="ANT_22180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22180"/>
    <dbReference type="eggNOG" id="COG1928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764654_0_0_0"/>
    <dbReference type="OrthoDB" id="1439481at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="355" mass="40557" checksum="8C141D6EC7684190" modified="2011-04-05" version="1">MPSSFYSARVIFANGVAASGVQVRLFDRDAPDGEDDDLTITPGTSDAQGFFTVEYDPSRARDVHLVRRVEPRNPPWDWTPVEREILEPDPNDTFIPYLLFQYALQDQEVKAVADLKSLHHTYVLPEVAQKPFQPSTHGFRFVNSFPGFFLPFSIPFFPESQSNSVYGLCGGMSAAALDFFFFNLPVPPRTQVPPTGSPLHQYLYQRQLDSFGRFGEVIRRFIEWMGLPDEGEKGTLKRTLDEFEKIRARLNNFTPVPLGIQYVKWRDTHQVWQNHQVLALRYERPATGQIRLYIYDPNYPGRDDVFIEAHKVDAGQGKEGLRCFQRVGNERTIPLYGFFALKYQPLLPPASAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY14</accession>
    <name>E8MY14_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N_BRCA1_IG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560614.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64245">
        <property type="protein sequence ID" value="BAJ64245"/>
        <property type="gene ID" value="ANT_22190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22190"/>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709119_0_0_0"/>
    <dbReference type="OrthoDB" id="1719087at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="N_BRCA1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N_BRCA1_IG" evidence="2">
        <location>
            <begin position="101"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="389" mass="41154" checksum="47A438F9D29A08B5" modified="2011-04-05" version="1">MKKRIWLIPVILVSILVFTACNLPIAPTSTPQNLASTLAAQTLEAMMTQVAANPTQEQGTPAPTLVPATATPGPTNTPAPSPTATPVPIPCDAAAFVGDVNIPDGTVMAPGQKFNKTWRIKNTGSCTWTKDYAVVFVDGNAMGASAAVNLTGPVAPGQTVDITVPLTAPSQPGTYRGNFKLRNPNNVVFGTGANGQFAFYVEIKVVPPATGDGYNFVYNFCNAEWSSGAGFLTCGGKDGDAKGFVIYLDKPRLENGQVDNEPALLTAPQNINDGVIRGKYPAIKIKSGDRFRAIVGCEYNAKNCNVRFQLDYQIGDGAIQTLAFWNESYEGSFTSVDVDLNALAGNDVRFILTVLANGSADGDRALWLMPRILNVPPTPTPTTPPTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY34</accession>
    <name>E8MY34_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560633.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22390"/>
    <dbReference type="EnsemblBacteria" id="BAJ64265">
        <property type="protein sequence ID" value="BAJ64265"/>
        <property type="gene ID" value="ANT_22390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22390"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139738_0_0_0"/>
    <dbReference type="OMA" id="RYWYHAW"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="137" mass="15507" checksum="062FCE2C3699E50B" modified="2011-04-05" version="1">MEHTPVTLPPWAQKAQFINLTTFRRNGQAVPTPVWFVAHEGRLYVMTNIQSGKAKRIRATGKARVAPSDVHGNPLGEFVEVRARPVEDESLRRALDAAFDRKYGIQRKIISLVANLRARQTGAPMYFIELELLDTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC8</accession>
    <name>E8MYC8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558471.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62073">
        <property type="protein sequence ID" value="BAJ62073"/>
        <property type="gene ID" value="ANT_00390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00390"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_441265_0_0_0"/>
    <dbReference type="OMA" id="DSIFMMP"/>
    <dbReference type="OrthoDB" id="595291at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="578" mass="61952" checksum="1597918CF6437DDC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYG4</accession>
    <name>E8MYG4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF5667 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_00750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558507.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00750"/>
    <dbReference type="EnsemblBacteria" id="BAJ62109">
        <property type="protein sequence ID" value="BAJ62109"/>
        <property type="gene ID" value="ANT_00750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00750"/>
    <dbReference type="HOGENOM" id="CLU_805729_0_0_0"/>
    <dbReference type="OrthoDB" id="1505856at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043725">
        <property type="entry name" value="DUF5667"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18915">
        <property type="entry name" value="DUF5667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5667" evidence="3">
        <location>
            <begin position="102"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="344" mass="37316" checksum="58169E79F8795D16" modified="2011-04-05" version="1">MREKFTPEEKKVLQTLEALRVVPERRAESHARGKEAFLAEARRMKSEGIPVSPAPVARLTVWNRLFGTKKEVFRMSPLVTLMLIVSLLFGGTGVTAVAAQNSLPDEPLYPVKLLTEQVRTELTTREQAQLALMLELANRRAEEANRLMAMGKAPSEALLARWQTHLEQATRLALQLGDEEARQALLRVQETLRQQMQWASSTASPARVREMLQEQQRLVEQGIAEPEQLRQRLRQNAPMQTAEPGENRNPWTDETPTPGSGYGPGPGTGDCTTCTPTGGGSQNPWTDETPTPGSGYGPGPGTGDCTTCTPTGGGSQNPWTDGTPTPGSGYGPGPGNESGGNRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYL1</accession>
    <name>E8MYL1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KipI antagonist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kipA</name>
        <name evidence="5" type="ordered locus">ANT_23210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64347">
        <property type="protein sequence ID" value="BAJ64347"/>
        <property type="gene ID" value="ANT_23210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23210"/>
    <dbReference type="eggNOG" id="COG1984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028967_0_0_0"/>
    <dbReference type="OMA" id="QDLGRSH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="26"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="323" mass="35119" checksum="CC800B3B06FC21F6" modified="2011-04-05" version="1">MNMAFWVEQAGWFTTVQDLGRTGYEHLGLPAGGAMDPFACKAANRLVGNEDSAAVLEFSGAGPTLWSDTPALIALCGGGFTLWVDGMEMPAWTAVRVRAGQRVECRPHLAGFWGVLAVSGGWDVPEVLGSRSTFLKANLGGYQGRLLQPGDWLFSLREGWLPEERAGAVLPASRRPVYSPEAVIRVVPGPQCAWFGEEGEREFLSAIFQVSAQSDRLGYRLTGATVPRRAGELLSEGIPRGAIQVPPDGNPIVMMADHPTTGGYPKIAGVIRADWGRMAQLRPGEGKVCFETVTLEQAHQLYRELMANLNAIELENFSFWMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYV0</accession>
    <name>E8MYV0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_24100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560792.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24100"/>
    <dbReference type="EnsemblBacteria" id="BAJ64436">
        <property type="protein sequence ID" value="BAJ64436"/>
        <property type="gene ID" value="ANT_24100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24100"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119870_0_0_0"/>
    <dbReference type="OrthoDB" id="1354786at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="196" mass="22343" checksum="BDF8DBA643E73BE9" modified="2011-04-05" version="1">MKRERWVQFFAPVNGESFGLLVNLLQNAVLDGTERVHLLLSTPGGTVSYGLTLYALLRGLPIEVWTYNVGQVDSIGVVVYCAGKRRLAAPQTRFLLHGIRTPLERGVYTTEQLREIVGEMETDQRNICRVLAESTGQALEKVERDLFHALTLLPEQAREYRLVDEIVTEIIPSQVSLTTIFIKDERHNERMYVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW9</accession>
    <name>E8MYW9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24290"/>
    <dbReference type="EnsemblBacteria" id="BAJ64455">
        <property type="protein sequence ID" value="BAJ64455"/>
        <property type="gene ID" value="ANT_24290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24290"/>
    <dbReference type="HOGENOM" id="CLU_1648623_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="160" mass="17500" checksum="39FB8EBDF2E3D8D9" modified="2011-04-05" version="1">MNLRDWRWYAAYGLVIGLVVLGVWRLLAPWGYDPGFLLGFLLTQGAAVLVGFVMHEGLHLWAALTQGVSAGSVKAGWFRFWVLEPVEVGTYRRIVLAPLMLPVLVGLLLAVVAPVRLALSAALLWLLGSADDLADWVRLWGVSGAVTNRPGEGLRLEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX2</accession>
    <name>E8MYX2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24320"/>
    <dbReference type="EnsemblBacteria" id="BAJ64458">
        <property type="protein sequence ID" value="BAJ64458"/>
        <property type="gene ID" value="ANT_24320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24320"/>
    <dbReference type="HOGENOM" id="CLU_2894072_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="62" mass="6754" checksum="F6982D341C16CF89" modified="2011-04-05" version="1">MGLLQNIPTAELEAALLDESHPLAKDLQTAVSVAVDAGRNLSRQIAVMALESVLRERRADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ71</accession>
    <name>E8MZ71_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558612.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01800"/>
    <dbReference type="EnsemblBacteria" id="BAJ62214">
        <property type="protein sequence ID" value="BAJ62214"/>
        <property type="gene ID" value="ANT_01800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01800"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OMA" id="YIVFQRQ"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="30741" checksum="DB06ABBCD44B01CB" modified="2011-04-05" version="1">MKAKSLRIGKNWLYAPLIFMSIFYLLPMYVMLVTGFKPFEEVNLKTMWALPHTIAFDNYVEAFRHLAPSLRNSFVMVIPATIISSFLGSLNGYVLAKWKFKGADVIFPLILFGMFIPYQSILIPLVQFMKSANLTGIPGLILAHVIYGIPITTLTFRNYYASLPQELIEAARIDGANMLGVYRWILLPISIPSFVVVLIWQFTSAWNDFLFAVVLTGNEQWPITVALNNMAGSQIIAWNVQMAGSLLAALPTLLVYLFLGQYFLRGLLAGSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA0</accession>
    <name>E8MZA0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558641.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62243">
        <property type="protein sequence ID" value="BAJ62243"/>
        <property type="gene ID" value="ANT_02090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02090"/>
    <dbReference type="eggNOG" id="ENOG5030M0E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1363861_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035168">
        <property type="entry name" value="DUF5317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17248">
        <property type="entry name" value="DUF5317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="200" mass="21833" checksum="E7A7277E15ABA4AB" modified="2011-04-05" version="1">MILLGAFSVGLVAVGLRALILRRELHPFDVRWMGLLFVAFLPQWFAFVLPTRFEIPDVWASLALVSSQIGLLLFALANVSKPGFPLLALGLASNLLVILLNGGWMPISPEMVQRVLPQASPDFWQIGARLGTGKDIVLPVEQTRLWVLSDIFFIHYGWNRAAFSPGDVLVALGVIRALWSLADRPAPARVSASPVAAQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA7</accession>
    <name>E8MZA7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02160"/>
    <dbReference type="EnsemblBacteria" id="BAJ62250">
        <property type="protein sequence ID" value="BAJ62250"/>
        <property type="gene ID" value="ANT_02160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02160"/>
    <dbReference type="HOGENOM" id="CLU_2986458_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="57" mass="6340" checksum="0D6E0F6C125F1B00" modified="2011-04-05" version="1">MKVELFDGRLNMSTLVSLFADSRKVRLVVFALMLVLFSFATSGFVFASNEEPPLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF9</accession>
    <name>E8MZF9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_24810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560862.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24810"/>
    <dbReference type="EnsemblBacteria" id="BAJ64507">
        <property type="protein sequence ID" value="BAJ64507"/>
        <property type="gene ID" value="ANT_24810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24810"/>
    <dbReference type="eggNOG" id="COG3258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074034_0_0_0"/>
    <dbReference type="OrthoDB" id="1469969at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="37"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="172"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="35477" checksum="0B2CEA049438B21F" modified="2011-04-05" version="1">MKSKGLMKAGLLFLVFGLIVLSGWVGQAQARGLEQDSDVPRGALLYDNWYAALGVQPPQGNMPVWERQTTNTRSGAETWRCVSCHGWDYQGKDGAYREGSDRYTGFPGVYPAVTQRTEEEIVAVLSGKVDPQHDFSPYIPEADLKALAHFLKTSLVNDNEYIDPKTFKVLGGDAANGKALYESQCARCHGADGATLRFRFEGRDATLGTLALLDPWRFLHKTRFGTPGTEMVIGYDLGWTAQQGRDVLLYVQSLPSGLEPQQSPSLGETVPSPVEQPGGPARNVFTGVLTAFGALFTGLGFALILGVFLIGVLFVIVWMIRGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG5</accession>
    <name>E8MZG5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560868.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24870"/>
    <dbReference type="EnsemblBacteria" id="BAJ64513">
        <property type="protein sequence ID" value="BAJ64513"/>
        <property type="gene ID" value="ANT_24870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24870"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_3_1_0"/>
    <dbReference type="OMA" id="GHDWFHI"/>
    <dbReference type="OrthoDB" id="1798994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="211" mass="24000" checksum="57B46970671E8ECB" modified="2011-04-05" version="1">MPTIEQARGWYSSADSVHDFDHILRVYQTAQHLGKIEGADMEILHAAVLLHDAIGSAPGEQARKAHHLASAEFAATILRLEGWDDERIAAVQHCIRTHRYRGTGEVPETIEAKILFDADKLDVLGAVGVARVIAYAALNRQPFYAEPSRQFLEQGILEPGEPHSAYHEYLFKLRKIKDRLFTTSARQLAEERDTYLREFFERFAREMRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ0</accession>
    <name>E8MZJ0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ordered locus">ANT_25120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25120"/>
    <dbReference type="EnsemblBacteria" id="BAJ64538">
        <property type="protein sequence ID" value="BAJ64538"/>
        <property type="gene ID" value="ANT_25120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25120"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_3_2_0"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="107" mass="11861" checksum="77B30B2863E5F0F6" modified="2011-04-05" version="1">MCMKYAIVESGGKQYKAVEGDTIEVDLLKVEPGQSVKLDRVLLLVDGEQVSVGAPVVKGAAVNATVVEHFKGPKLINFHYRPKKRIRVKTGHRQTYTRLLVNSIEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZL0</accession>
    <name>E8MZL0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560913.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25320"/>
    <dbReference type="EnsemblBacteria" id="BAJ64558">
        <property type="protein sequence ID" value="BAJ64558"/>
        <property type="gene ID" value="ANT_25320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25320"/>
    <dbReference type="HOGENOM" id="CLU_1493245_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="20069" checksum="4287B581D447DF9C" modified="2011-04-05" version="1">MTQPVRLIPLLCPHCQNPIPAQPDEVAWVCTNCQKGLLLDESKGAVPLNIFFHAGLSAGKTGAPFWVTRGRVVFQQRETYRGNEKKAMQAFWAEPRLFAIPAYALPLEEAIALGVKFLQQPLKMEAGKPAPFLPIVVSPQDVHPLAEFIVMSIEAERKDALRQLTFTLSLEPLQCWILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR4</accession>
    <name>E8MZR4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">eRF1_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560967.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25860"/>
    <dbReference type="EnsemblBacteria" id="BAJ64612">
        <property type="protein sequence ID" value="BAJ64612"/>
        <property type="gene ID" value="ANT_25860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25860"/>
    <dbReference type="eggNOG" id="COG1503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061559_0_0_0"/>
    <dbReference type="OMA" id="PRPREWE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041202">
        <property type="entry name" value="BaeRF_family10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18854">
        <property type="entry name" value="baeRF_family10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_3" evidence="1">
        <location>
            <begin position="253"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="365" mass="40673" checksum="8BF918B1AEEEDAA8" modified="2011-04-05" version="1">MFTEHDLRELVEFVAPAPVLSLYLNTDPSEGNADFHRLRARSMLKDINLPQDVEAIHRYLDFEYPFTGGGVAIFSCAQEGFFRGIPLAVPVRNAIHVGDRPSVKILAGLLDSYGGYGVVLVDKQGARLFYFHMGTLVEQEGIMGEAIKQVKRGGASSFPGRRGGVAGRTRAVEEQIERNMKDTVEYATRFFEHHKVRRILIAGTDENVQQFRSHLPKSWLSLVVGTFPMSMTASHAEVLQRAMQVGNEAEKHREERLIEDLITFAAKGASAVVGLEDTLQAVNQGRVQTLVISEGFRKVGYRERETDFLTTQPSEEGINEGRYIKVYDVVELAVNHTLRSGGDVDVVMQAEKMEKAGNIGAFLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX3</accession>
    <name>E8MZX3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ordered locus">ANT_02740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
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    <dbReference type="EnsemblBacteria" id="BAJ62308">
        <property type="protein sequence ID" value="BAJ62308"/>
        <property type="gene ID" value="ANT_02740"/>
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    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_0"/>
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    <dbReference type="OrthoDB" id="1965002at2"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
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        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="91" mass="10060" checksum="82B920A3DB7D2E94" modified="2011-04-05" version="1">MSALKIQPLGSRVVIKPLEQESKTPSGLYIPETAKEKPQYGVVVAVGDSEDIKLKVNDKVLFAKYSGTEFKLDGQEYLLMECSDVLAKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N005</accession>
    <name>E8N005_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03060"/>
    <dbReference type="EnsemblBacteria" id="BAJ62340">
        <property type="protein sequence ID" value="BAJ62340"/>
        <property type="gene ID" value="ANT_03060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03060"/>
    <dbReference type="eggNOG" id="ENOG502ZN8K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103909_0_0_0"/>
    <dbReference type="OMA" id="QIFRTHK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228521" evidence="1">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="115" mass="12568" checksum="957A2292138B02D4" modified="2011-04-05" version="1">MNAQIFRTHKLRFFCSLLAFLLLLTFSATFSTQSQPAKAEALSAEPLAGTGYEITWWTVEGGGLTWSQNGGYSLGGTIGQPDAGVLQGNTYTLKGGFWAGARIQRNVYLPYIRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N091</accession>
    <name>E8N091_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560994.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26140"/>
    <dbReference type="EnsemblBacteria" id="BAJ64640">
        <property type="protein sequence ID" value="BAJ64640"/>
        <property type="gene ID" value="ANT_26140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26140"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497527_0_0_0"/>
    <dbReference type="OMA" id="YPTWQMS"/>
    <dbReference type="OrthoDB" id="845966at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="253"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="547" mass="62815" checksum="79DF0F935D99794E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B3</accession>
    <name>E8N0B3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_26360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561016.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26360"/>
    <dbReference type="EnsemblBacteria" id="BAJ64662">
        <property type="protein sequence ID" value="BAJ64662"/>
        <property type="gene ID" value="ANT_26360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26360"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024978_0_0_0"/>
    <dbReference type="OMA" id="NILWYKK"/>
    <dbReference type="OrthoDB" id="627025at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228528" evidence="4">
        <location>
            <begin position="25"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="670" mass="76410" checksum="5DC7108DEDC8FD65" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F8</accession>
    <name>E8N0F8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561059.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26810"/>
    <dbReference type="EnsemblBacteria" id="BAJ64707">
        <property type="protein sequence ID" value="BAJ64707"/>
        <property type="gene ID" value="ANT_26810"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG2836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047817_0_0_0"/>
    <dbReference type="OrthoDB" id="710004at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD_2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="3">
        <location>
            <begin position="260"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="352" mass="37765" checksum="30484E15EFD3F862" modified="2011-04-05" version="1">METLWVAFITGLTTGGLSCMAVQGGLLASSLAGQIEQDVAQRAMQKKKAHTVSFSPRPALALPILAFLLAKLVAYTLMGALLGVLGSLFELTPAMRAVLLFGVGFFMLGNALRMLNVHPIFRYFSFEPPQAVRRWLRRTSREDHHWFTPLMLGALTVFIPCGVTQTMMALAVGTGSAAQGAAILFAFTLGTSPVFFGLAYLATSLGSRLEKHFNRVAAVLLIILAVVTVNSGLNLIGSPLSAENLSRNALKSFQPDAPNQVADASNTLTLQVRDDGYFPAELTARAGEPVTLQLVTENTFSCSRAFLIPALKVQRLLPATGTEIVEIPPQKAGTTLHFTCSMGMFTGTITFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I1</accession>
    <name>E8N0I1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27040"/>
    <dbReference type="EnsemblBacteria" id="BAJ64730">
        <property type="protein sequence ID" value="BAJ64730"/>
        <property type="gene ID" value="ANT_27040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27040"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_4_0"/>
    <dbReference type="OMA" id="DGDYQHK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="240" mass="26952" checksum="671476888A068638" modified="2011-04-05" version="1">MLSLKPIPIPEETMTSDHSPILALIPAHNEAARIAPVIAGARQHLPVLVVDDGSTDDTARVANAAGAEVVRQTPNRGKGEALKTGFRWALERDFDAVLTLDADGQHDPAEIPAFLEKWAQTRADLIIGARDFRQMPLHRRLANTSGTWLFSWAVGRSIRDNQSGYRLISQRLMEEALASAHGGFEFEVDMIVICIQRNYKLEWVNIRTIYGDEKSHIQPFRHVQGFIRLALATRRLMKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J6</accession>
    <name>E8N0J6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_27190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561097.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64745">
        <property type="protein sequence ID" value="BAJ64745"/>
        <property type="gene ID" value="ANT_27190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27190"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="WGTYLVK"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="584" mass="65526" checksum="B52DAA167DD5346B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T5</accession>
    <name>E8N0T5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558876.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04460"/>
    <dbReference type="EnsemblBacteria" id="BAJ62480">
        <property type="protein sequence ID" value="BAJ62480"/>
        <property type="gene ID" value="ANT_04460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04460"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_1_4_0"/>
    <dbReference type="OMA" id="CINVLPA"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="167" mass="18718" checksum="9C86ACB1EA81C3C5" modified="2011-04-05" version="1">MTELTLSPRGEDLRRAMRRWVTGVSIVTAAHEGKRHGMTVNSFVSVSLDPPLVTVTLANTTRTHKLVSASGRFGVTILDIHQQNLSDRFAGRIPEDGDRFHDVQIFSLSGEIPLLSDGLAALECRVVHCYEMPHSTLFIGEVEQVWIREDGEPLVYVNRAYRCLKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0X0</accession>
    <name>E8N0X0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prpC</name>
        <name evidence="8" type="ordered locus">ANT_04810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04810"/>
    <dbReference type="EnsemblBacteria" id="BAJ62515">
        <property type="protein sequence ID" value="BAJ62515"/>
        <property type="gene ID" value="ANT_04810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04810"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_0"/>
    <dbReference type="OMA" id="LTYCGYD"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="385" mass="43042" checksum="282AAB91ECAA4E71" modified="2011-04-05" version="1">MAEMSVVQETPRKKSVALSGVPAGNTAICRVGFEGNDLRYRGYDINDLAEHSTFEEVAFLLVHGKLPLASELERYRLKLKRLRGLPAPVKAALELIPAAAHPMDVLRTGVSMLGATLPEREDHNAEGARHIADHLLAIMPSILLYWYQYAHHGRRIEVETDDDSIAGHFLHLLHGRRASDLHQRALDITLILYAEHEFNASTFTTRVIAGTGSDIYSAITGGIGALKGFKHGGANEGAMEIIERYRTPDEAERDVRRIIKEKGIILGFGHPVYTISDPRAKILKELSCTLCKDFGDESMCDIAERIEAVMWEEKNLFPNLDWYAAVTYHMMGIPTFMFTPLFVMARTAGWAAHIIEQREDGKIIRPSANYIGPEPRAYVPIMKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0X2</accession>
    <name>E8N0X2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative type II restriction enzyme</fullName>
            <ecNumber evidence="1">3.1.21.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.4" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558913.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04830"/>
    <dbReference type="REBASE" id="32151">
        <property type="entry name" value="AthUNI1ORF4840P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62517">
        <property type="protein sequence ID" value="BAJ62517"/>
        <property type="gene ID" value="ANT_04830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04830"/>
    <dbReference type="eggNOG" id="ENOG502ZBR5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1203501_0_0_0"/>
    <dbReference type="OMA" id="IAWQNIG"/>
    <dbReference type="OrthoDB" id="958839at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="236" mass="26802" checksum="418795F7164D8975" modified="2011-04-05" version="1">MSHKIAEIQNAYNILVGSIDERAHADNEEGNRAYGGAVRSAKGILVEGIAQNLVKIAWEELGEDPNRLSFIRENIKIPLKPEYLRRVRPAEVAEYIKAHIEQYFYGHKTDVHVSIDGQFVMGIECKAYTENAMLKRILVDFTLLKEVVPNLKCVLIQLESQLGGDYSQPLNKIIYGSTSTHTLLSYFDVDLNIITLLEGERKVDEPIHKQPYFKEMTEPALRKAVETLKALLSDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z6</accession>
    <name>E8N0Z6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558937.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05070"/>
    <dbReference type="EnsemblBacteria" id="BAJ62541">
        <property type="protein sequence ID" value="BAJ62541"/>
        <property type="gene ID" value="ANT_05070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05070"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_2_0"/>
    <dbReference type="OMA" id="TMSTPGN"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="163" mass="18313" checksum="AA73B22378DDA6CD" modified="2011-04-05" version="1">MPTHYQGDPQIKLALDTFIKFTRASSALESYLFHDGILEGLTPSQFGVLETLYHLGPLCQGEISHKLLKSTGNITLVLDNLEKRGLIERQRSREDRRMVTIVLTEAGRELIERVFPRQAALIAEAFSPLSSEEQRTLGELCKKLGLALQQKNSPHLTHIHSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N117</accession>
    <name>E8N117_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase, subunit III</fullName>
            <ecNumber evidence="9">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_05280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558958.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05280"/>
    <dbReference type="EnsemblBacteria" id="BAJ62562">
        <property type="protein sequence ID" value="BAJ62562"/>
        <property type="gene ID" value="ANT_05280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05280"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044071_4_2_0"/>
    <dbReference type="OMA" id="SIYWWGS"/>
    <dbReference type="OrthoDB" id="1502742at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="192" mass="21352" checksum="7FD849C697B9608E" modified="2011-04-05" version="1">MATQTTALEQAHSHAYKLRTARIGLWLFILSDSFVFAGLLVTRFYLLGGHRPELEQLVGVIVTSVLLISSFFMNRAEVQISRGNRKGFITSTAITMALGIAFLIGVVGVEWQIAPFGPADGAQGAVFYMMTGMHAFHVLTGVIFLGIILRNGLRGHYSPERHWAVEAAANYWHFVDVVWIFYYPALYLIGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N122</accession>
    <name>E8N122_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62567">
        <property type="protein sequence ID" value="BAJ62567"/>
        <property type="gene ID" value="ANT_05330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05330"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514874_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="107"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="177" mass="20361" checksum="2C1EFB58D09985BD" modified="2011-04-05" version="1">MGMKSAEINLNFLGDGIALDFFSNSVIIIEQKFYKEIIGMTRILFLPDPHTLLWLEEEQPAEAILQALQRGEWLPPAPFHELPCADLRALQIEDMVLITRTAPRAVVQPYLPHLSRRQMEVLKGLAEGLTTRQIAYRLRISTRTVYLYVSDLKRRFDAGTRAELVRRAMIVLSSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N143</accession>
    <name>E8N143_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD dependent oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_27600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561134.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27600"/>
    <dbReference type="EnsemblBacteria" id="BAJ64786">
        <property type="protein sequence ID" value="BAJ64786"/>
        <property type="gene ID" value="ANT_27600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27600"/>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_0_1_0"/>
    <dbReference type="OMA" id="CIVNAAG"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="4">
        <location>
            <begin position="5"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="386" mass="42018" checksum="3E3F4B5F8A665A45" modified="2011-04-05" version="1">MTKPHAIVIGAGFTGVAIAWDLTQRGFRVSVVERGPIANGTSGRTHGLLHSGARYAVNDQESAIECIQENLILRRIVPDAIEPNGGLFVAVQEEDLAYREKFIEGCAACGIPIRELTPQEVLRLEPNLNPRLLTAFTVPDATFDPLRLALAFAASAKAGGAQFYLYTDVVDLLRDGRGNVCGVKAWNRAADQRFHLPAEVVINATGAWVGQITAMAGVQVPITPTPGVMVAYDKRLTQRAINLLNEPGDGDIVLPQRRMMVVGTTSFTIEDPDYVPVYEDHVALMMERGAALIPALRQTRERGAYMATRPLIGATAPGRSISRTFKAYDHAETDGIEGLVTITGGKATTLRLMAEKTVDVVCRKFGIEVPCRTAETPLLSYRKFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A7</accession>
    <name>E8N1A7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_28240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561196.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64850">
        <property type="protein sequence ID" value="BAJ64850"/>
        <property type="gene ID" value="ANT_28240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28240"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068384_0_0_0"/>
    <dbReference type="OMA" id="FMRREIR"/>
    <dbReference type="OrthoDB" id="1451344at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="35683" checksum="7121D7B40B41D8EA" modified="2011-04-05" version="1">MALAERVQSRREGSPWTGLWAVVAKEMADHLTSARMRILELLILLTAGGTVYVAMQQIRSAGISEQFVYLRLFTLAQDPLPALVGFLVFLVPLIAIALGFDAVNGEFNRKTMSRILSQPIYRDALLMGKFLAGLFTLALVFTAIWLLIFGMGMIGLGVAPGSEDVGRLLWFLVATVFYGGIWLALAQMFSVTFRQPATAALASIAVWLFFTVFWEILAGLLAQALRPVQFGLAQEILGQAQLQMTLERFSPNTLYAESMVALLNPTVRSLGLVLPSQLQGAILGTPLPLSQSLLLIWPHLTGLIAVTILIFALSYVLFQRQEIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C7</accession>
    <name>E8N1C7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561215.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28440"/>
    <dbReference type="EnsemblBacteria" id="BAJ64870">
        <property type="protein sequence ID" value="BAJ64870"/>
        <property type="gene ID" value="ANT_28440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28440"/>
    <dbReference type="eggNOG" id="COG1688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102545_0_0_0"/>
    <dbReference type="OMA" id="SFRYPHF"/>
    <dbReference type="OrthoDB" id="1400944at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="239" mass="27992" checksum="F8957F85C30920C0" modified="2011-04-05" version="1">MRALKIVAEGLTASFRYPHFMMGVQPTFEMPPPATLYGHVASALGEWFDPQGVRFAVRFEFRRKQADVETTYLLTPANGKMPGDKSLPKALEGNPNPFQREILYFPRLTLYLNRPEWLEAFRHPRYAVCLGRSQDLFTYRRVEVVELQPAEQVVLEHTLLPYEYAAYTAAGQAVLMPRWLDYHRRRYPAFERYIVLHRRVRTREFTRYTGQPALEPWWADPAEPPLDGEYPGVVWLSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C9</accession>
    <name>E8N1C9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561217.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64872">
        <property type="protein sequence ID" value="BAJ64872"/>
        <property type="gene ID" value="ANT_28460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28460"/>
    <dbReference type="eggNOG" id="ENOG502Z8CM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032781_0_0_0"/>
    <dbReference type="OMA" id="LLFRIYE"/>
    <dbReference type="OrthoDB" id="1211272at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="489" mass="54676" checksum="098689AFC0A371A1" modified="2011-04-05" version="1">MSELPFSPPDYTGHPLLDVGLATLTAFAGKTRPTQLTGEDLENAARYIRENYIVDPLKSFLNVAFPNSGFTNPAFEKQPEKRRRYAEIVSGAFAAPAGEERDPLTGLPATALALNPDGNMPPGRTYRQHVPLLTGVDVINFHPYGEAGIPLSGISLLAFQMLPMGCAKVSGKLLAVHSDDPNLLLAFAKTFLTANLQGVTAARAGGEKKLPDTSPHRARTVLIEHLFEAEKARGRQQEENGGLPPTLTGYYFTNSGQGAELDIYPLPLEVGGFLRAVLHNDLLKPEWEALAARGWQLTRKEGETPRYNRLFEDLFTLPEGAPRFIRLYFLRKPSRQTADKQDPTLTYDTRREVDLISWRLTELFLRKVMLMEDSRVQSIRELGDALAQYILDRNDRGVFNNFWMARNYGELRAVLLRASAAEVRAGRKPLITLDQFLAIFEQSEGVPNADWRLGRDLVLIRLLEQLYQKGWLQAHAGELPETAPEEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E3</accession>
    <name>E8N1E3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561231.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28600"/>
    <dbReference type="EnsemblBacteria" id="BAJ64886">
        <property type="protein sequence ID" value="BAJ64886"/>
        <property type="gene ID" value="ANT_28600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28600"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_0_0"/>
    <dbReference type="OMA" id="WYMYLAD"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228595" evidence="2">
        <location>
            <begin position="26"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="459" mass="49389" checksum="80274636028DB6E4" modified="2011-04-05" version="1">MSHKLFRLFSLVMIAVLLLTACAPATTPTATEPPAEEQPTQPPAEEPTKPPAAEPTKAPEKKVVITWWHISTAEEHKALWQTFADEYMAAHPNVDIQITVLENEAFKSKMTTVMQSGTPPDIFQSWGGGVMIEYAKAGLLRDITPELDANGGEWRNTFSPGALGVYAFEGRNYGVPWDMGMVGFWYNKALFAQAGIEKPPATWTELLEDVKKLKAAGITPIALGAGDKWPAMFWWAYLAVRLGGKDAFEAAYSRQGSFTDAPFVEAGKKLQELIALEPFQEGYLGATYGDQATLMGNGKAAMELMGQWAPSVQKDNSADKQGIGDNLGWFPFPMVEGGKGDPDDAFGGGNGFAIGKNATPEAIDFVKYLTSVDCQVRLAKINVALPVVKGGEAGVSDPLLLAVQQGAAKAKYFQLYYDQALPPAVGSVVNDSVQGLFAGTLTPEQVAQAIEDSAAMELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I2</accession>
    <name>E8N1I2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aminopeptidase</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_05530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558983.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62587">
        <property type="protein sequence ID" value="BAJ62587"/>
        <property type="gene ID" value="ANT_05530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05530"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_0_1_0"/>
    <dbReference type="OMA" id="FMAHMDE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="356" mass="38411" checksum="DA17A5D9F5020755" modified="2011-04-05" version="1">MSPATPAPQIGAEQIALLEKLSNACAVSGDEAQVRKIVLEEIKPFADDLRVDALGNVLAVRKARTPNALRVMVDAHMDEVGFMIVEDDKDGLFRFVAVGGLDERTLPGKKVLVGAENVPGIIGAKPIHLTEEGETERKIPIESLRIDVGLKGGKKVKVGDRATFATRFWQSGNALFGKALDDRLGVATLIELFKNPPENIELLAAFTVQEEIGLRGARPAAYAFNPQLAIALDSTPANDLPMWDGSENIFYNTRLGAGPALYIADSATLSDPRLVRHFAQTGEQMGIPFQFRQPGGGGTNAGAIHRVREGVPSLSVSVPGRFAHTAIMLARLDDWQNTLALVYYALSRLDAGILQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M2</accession>
    <name>E8N1M2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ordered locus">ANT_05930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559022.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05930"/>
    <dbReference type="EnsemblBacteria" id="BAJ62627">
        <property type="protein sequence ID" value="BAJ62627"/>
        <property type="gene ID" value="ANT_05930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05930"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_0"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="74"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="108"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="35611" checksum="41077F7A63F7067A" modified="2011-04-05" version="1">MLKPYIAKVMNFQSLSAQEAEEAMNIIMNGEATPAQIGGYLVALRMKGETVEEITGSARAMRAHASRVKVQSTPLIDTAGTGGDGAHTFNISTAAAFVIAGTGRKVAKHGNRAASSRCGSADVLDALGVRINLTPEQVARCIEEVGIGFLFAPSFHPAMKHAVAPRRELGQRTLFNLLGPLTNPAGATHQLIGVYDGKLTSMLAEVLGELGVQGAFVVHGHGGLDELSTSGPNRISRLHDGRVENEELDARDLGLRQATPEDLRGGEPAENASILRAILENRDDSPRRDVVLLNSAAAIAAECGDLTRALAEAEHSLSSGAALQKLEALVTYSQQVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q1</accession>
    <name>E8N1Q1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssb</name>
        <name evidence="5" type="ordered locus">ANT_06220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559051.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06220"/>
    <dbReference type="EnsemblBacteria" id="BAJ62656">
        <property type="protein sequence ID" value="BAJ62656"/>
        <property type="gene ID" value="ANT_06220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06220"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_0_2_0"/>
    <dbReference type="OMA" id="SGSVKCR"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="140" mass="15183" checksum="608EDECEAAB8F21C" modified="2011-04-05" version="1">MTFHTIIIVGNVGREPEMRYTPAGQPVTSFSVASNRSYTNQQGEKVDETIWFRVSAFGKLAETCNQFLHKGSRVLVEGRLVPDKNGSPRIWTRQDGTAGASYEVTATTVRFLSARGEGGAEAGGDLTIPDVGDMGEDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W8</accession>
    <name>E8N1W8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561260.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28890"/>
    <dbReference type="EnsemblBacteria" id="BAJ64915">
        <property type="protein sequence ID" value="BAJ64915"/>
        <property type="gene ID" value="ANT_28890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28890"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_5_2_0"/>
    <dbReference type="OMA" id="TSPLWGM"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="152"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="305" mass="33053" checksum="767292A3D2710B0A" modified="2011-04-05" version="1">MTLKNWLIFLALGTIWGSSFLWIKVGVGEIGPFMLVTLRVVVAFTALALVIARKRTILPDLRRTWWIFAVLGLFNLAVPFVLISTAEQSLSSGLAAILNATVPLFTLVIAPFFISEERMTLPRLGGLLVGFAGVVVLMSDELRAGANWGDLKGQALMLLATFSYGAASVFARLKTRGMPVEVQAGGQALFASLAMLAILPFAENPLVFPRLPITWLAVLWLGVLGTCLATLMYYYLLHEVGPTRATLVTYLFPLVGVVLGAVFLRERLQVWHLLGGAMILSGIVLVNRYKPPAAVAVTPETAQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X0</accession>
    <name>E8N1X0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">purA</name>
        <name evidence="11" type="ordered locus">ANT_28910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561262.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28910"/>
    <dbReference type="EnsemblBacteria" id="BAJ64917">
        <property type="protein sequence ID" value="BAJ64917"/>
        <property type="gene ID" value="ANT_28910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28910"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_0"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="304"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="418"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="429" mass="46085" checksum="479A01B5A8A50438" modified="2011-04-05" version="1">MPLEIVIGTQWGDEGKGRVVDLLSARADIVARYNGGDNAGHTVTVGEKVFKLHLIPSGIIHPGTIGVIGNGVVVYPPTLFSEIEMLEQNGVEASPQRLRLSHAAHLITPAHRALDRAQEVARGAGQIGTTGRGIGPAYTDKAARRGIRLEEMLNPEAFHKRMLAHVEEANQWLVGVYQAEALDPQAVADEYAEYAEKMHPYITDTSLLLWQALQNGQTVLAEGAQGTLLDLDHGTYPFVTSSTPTAAGALVGLGLGPGTAARVIGVTKAFQTRVGAGPFPTEVSGEMATRLRGTGANPWDEYGTTTGRPRRVGWLDGVLLRYAVRVNNVTDLVVTKLDVLSGLPSILLCTGYRVNGSVLTDLPLGPADLSPFEPVYEELPGWTADVRGARSWKDLPREAQRYLSRISELCGVPVCQVSVGPEREQVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N230</accession>
    <name>E8N230_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561321.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29510"/>
    <dbReference type="EnsemblBacteria" id="BAJ64977">
        <property type="protein sequence ID" value="BAJ64977"/>
        <property type="gene ID" value="ANT_29510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29510"/>
    <dbReference type="HOGENOM" id="CLU_1976954_0_0_0"/>
    <dbReference type="OrthoDB" id="1928372at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021414">
        <property type="entry name" value="DUF3054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11255">
        <property type="entry name" value="DUF3054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="126" mass="13906" checksum="F1BEB979DFABA51D" modified="2011-04-05" version="1">MRVRWMDFLPLFFGDAVAVFVISVVGFAFHGSALARVWSTFLPMLIGWALIAPWLGLYQPQVFSRMPQVWRAGLAALLAAPIAGVLRGWWLNSAVLPVFVGVLGATAALGMILWRALWAWHTGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N243</accession>
    <name>E8N243_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561334.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64990">
        <property type="protein sequence ID" value="BAJ64990"/>
        <property type="gene ID" value="ANT_29640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29640"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_1_1_0"/>
    <dbReference type="OMA" id="VGFWFHF"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="315" mass="35330" checksum="9DE4ED25A3D8AAFA" modified="2011-04-05" version="1">MNKREVMFNLLEEGQSPPYIPAAFFLHFDPAFHRGEAAVQKHLEFFRATGMDFVKIQYEHTFPQLPFIQRPADWAKMPFYDLDFYAEPLAVVKGLVQAAKPEAVVVLTLYSPFMCAGHTLGSDRALSRHIEEDPEAVKKGLSIITKSLLEFVRACAALGLDGFYTSTQGGEAGRFSNPALFDEVIRPFDRLLMDEVNRLTPFNILHICDYHLPYERVDGFLDYPGQVVSLGMELTTRTLTPAEAYALFRRPILGGLNRHGVIAHGTPEQIRAEVESVCAAAPPRFILGADCTVPSETPWENLRTAIETAHTFRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N298</accession>
    <name>E8N298_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561386.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30190"/>
    <dbReference type="EnsemblBacteria" id="BAJ65045">
        <property type="protein sequence ID" value="BAJ65045"/>
        <property type="gene ID" value="ANT_30190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30190"/>
    <dbReference type="eggNOG" id="COG5319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113286_1_0_0"/>
    <dbReference type="OMA" id="CHTIFNF"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="139" mass="15740" checksum="76D850E1AC6D3EA1" modified="2011-04-05" version="1">MPYYDYRCLDCNRRFSLFFTYAEYGVKPAVCPHCGSEHVQRRINRVRIARSEESRLESLADPSNLEGLDEDPRALGRMMREMSREVGEDMGPEFDEVIHRLESGQTPEQIEQEMPELAESLGAGGEDEGGFGADFGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A2</accession>
    <name>E8N2A2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30230"/>
    <dbReference type="EnsemblBacteria" id="BAJ65049">
        <property type="protein sequence ID" value="BAJ65049"/>
        <property type="gene ID" value="ANT_30230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30230"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112782_0_0_0"/>
    <dbReference type="OMA" id="LGYEWMT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="195" mass="22189" checksum="84149B5599F5990D" modified="2011-04-05" version="1">MKERVMASISTFFKGEALELQDPSWAKFLFNDRRAAWLWLVVRIWLGWQWIEASLHKINDPKWVVTGEALKGFWTRAVAIPEPPARPPIAFDWYRAFIQSLLDAQSYTWFAKLVAYGELLVGIGLIVGAIVGITAFFAALMNWNFMMAGTASTNPLLFLVAILLILAWKVAGYYGADFFILRWLNRNKTPQAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B8</accession>
    <name>E8N2B8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559118.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06900"/>
    <dbReference type="EnsemblBacteria" id="BAJ62724">
        <property type="protein sequence ID" value="BAJ62724"/>
        <property type="gene ID" value="ANT_06900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06900"/>
    <dbReference type="HOGENOM" id="CLU_1745890_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021994">
        <property type="entry name" value="DUF3592"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12158">
        <property type="entry name" value="DUF3592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="149" mass="16847" checksum="120B14A3BB1E8C6E" modified="2011-04-05" version="1">MNPQASLKKILLTDYGAFLGWMIPMAYLGVILLQFFLGETLEVILRLALVLLPLSLAGLALAFWRVRLIRRVIEEGVQMPATIVRASFFRGRGRVEVVYTYQGERVVSGNVVMKNKLTSAFQLGTPVTVMVDREKPRRAFILELYAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C4</accession>
    <name>E8N2C4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559124.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06960"/>
    <dbReference type="EnsemblBacteria" id="BAJ62730">
        <property type="protein sequence ID" value="BAJ62730"/>
        <property type="gene ID" value="ANT_06960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06960"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="RTRGQMW"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="340" mass="38572" checksum="7342BD14C80FBBF5" modified="2011-04-05" version="1">MEQPLAIRTEHLGRVYKIRNNRKEAFRELTALQDVNLEVRRGELFGLLGPNGAGKTTLIKILTTLLAPTSGKASVAGFDVLTQAEEVRKRINMVSGGETSGYGLLTVRENLWMFAQFYGIESKEAHRRIDTLMEIVGMKDRLNTKSSDLSTGLRQKMNIVRGFLTDPEVLFLDEPTLGLDVGASRDVRAFIRRWMDENPQRTLLLTTHYMVEAEELCDRVAIINQGRVLACDTPDNLKRQLQKEAIFQVWVKCEHLLDEQAFTALAGLRHFHQTFENGSLRLELILDEESVLTSVLNRLVESQARILRLEKRQPTLEDVFVQLVGQRLEEVEGEPDASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2E8</accession>
    <name>E8N2E8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ethanolamine ammonia-lyase small subunit</fullName>
            <shortName evidence="4">EAL small subunit</shortName>
            <ecNumber evidence="4">4.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">eutC</name>
        <name evidence="5" type="ordered locus">ANT_07200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ethanolamine = acetaldehyde + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15313"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="EC" id="4.3.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
        <text evidence="4">Binds between the large and small subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine degradation; ethanolamine degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.7" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559147.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07200"/>
    <dbReference type="EnsemblBacteria" id="BAJ62754">
        <property type="protein sequence ID" value="BAJ62754"/>
        <property type="gene ID" value="ANT_07200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07200"/>
    <dbReference type="eggNOG" id="COG4302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068224_2_0_0"/>
    <dbReference type="OMA" id="ADRNCVS"/>
    <dbReference type="OrthoDB" id="1115166at2"/>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008851">
        <property type="term" value="F:ethanolamine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00601">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009246">
        <property type="entry name" value="EutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042251">
        <property type="entry name" value="EutC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042255">
        <property type="entry name" value="EutC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39330">
        <property type="entry name" value="PTHR39330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05985">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018982">
        <property type="entry name" value="EutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="1 4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="2 4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="301" mass="32487" checksum="2F640C0AF71B2411" modified="2011-04-05" version="1">MEQGKVDIEAIVQAVLAELSKKNAEQQVPSQNQKASNGDLIIDLPDPTLPESRFAPGVKKPYDSEGLRNLMSTTTARIGVGRAGPRPRTSTLLLFQSDHGVTQDAIYGEVEQAVLDKFDLFTVQTLVEDRNQYLTRPDLGRKLSEEAKRIIAERCVKKPQVQIVVGDGLSAAAINNNLPVIYPVILQGLKSANISVGTSFFIKYARVGVINDVNDIIGADIVVILIGERPGLGIADAMSAYMGWRPTAGKTDAERDVVCMITVHGGTNPLEGGAFVVDMIKKTLQYQASGVELKLKTSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F2</accession>
    <name>E8N2F2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilisation EutQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eutQ</name>
        <name evidence="1" type="ordered locus">ANT_07240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559151.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62758">
        <property type="protein sequence ID" value="BAJ62758"/>
        <property type="gene ID" value="ANT_07240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07240"/>
    <dbReference type="eggNOG" id="COG4766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082122_0_0_0"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="PTHR36169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06249">
        <property type="entry name" value="EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="205" mass="22624" checksum="C187251B6E324475" modified="2011-04-05" version="1">MAKKCYTAQDVRSLADQKVLELKLSPGELITPLARDAARELGIKIIEVEKEQPGSQTRAEVVSSSLEEQVRQIVGKLLEKGDNSVTPKRASVVHVDGRSLVMPPFSFEINRPEMDVRLEDVITAQHGSPMAAGFMTLHKGSFPWTLTYDEIEFVIEGELHIATDQGTVVGKPGDVIFIPKGTKISFGTPQWAKFLYVTYPAEWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K2</accession>
    <name>E8N2K2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_07740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559201.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07740"/>
    <dbReference type="EnsemblBacteria" id="BAJ62808">
        <property type="protein sequence ID" value="BAJ62808"/>
        <property type="gene ID" value="ANT_07740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07740"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_7_0"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="330"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="439" mass="47606" checksum="6647BAEAAD86200B" modified="2011-04-05" version="1">MRFLDYLGLVFYNLGRRKGRVALTAIGVVIGTAAVVVLVALASGLQRNATRQFSQVGNLTLITVYPKYGEGMVVMPGGGSSGGSGQSQIKLLTPQAIAEISAIDGVAQVIPRDTLRGGARLVAGKMETYPFIMAYDTPDFSVFNYQMKEGVSELKRGEALVGESLAKGFNDPRWRPGQPQPEQPEIVGKQLKLVVQKFSQDGTMTERVYSVRIAGIIKQRMDETDYGMIMRMDDLTQMNEWLTGKRINRNKEGYDMFYVKTTDTKKTTEVSKQINDLGYQAYSQMEFVQSVNNFYTIIQIVFGGIGAIALLVAAIGIANTMTMAILERTREIGLMKAVGATNRDVMSIFLGEAGGIGLIGGIGGVMLAWGLAQIINVLAASYLSNPMPYGGEPPGPATYIAPWLPLFALVFSTLVGVISGLYPALRAATMVPVMALKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N4</accession>
    <name>E8N2N4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559232.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08060"/>
    <dbReference type="EnsemblBacteria" id="BAJ62840">
        <property type="protein sequence ID" value="BAJ62840"/>
        <property type="gene ID" value="ANT_08060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08060"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_2_1_0"/>
    <dbReference type="OMA" id="QSFYVMA"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="191"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="344" mass="38221" checksum="6BABA638CECC4911" modified="2011-04-05" version="1">MILHDEILEQPQRLRHLLENQRETAQRIAQAIRSHDVQYVVIAARGTSDNAARYATYLWGALNGLPVALATPSLFTYYQTPPRMRGALVVGISQSGQSPDIVQVVEEGKRQGCLTLAITNTPDSPLAQIAEHHFDIQAGAEKAVAATKTYTAQLTAIAMIAAALSESSELWAELWQLPAWAEEVLKDEARIEQAVQRYRYMERCAVLGRGFNYATAFEWALKLKELTYVAAEPYSSADFLHGPIAMIQEGFPVMVVAPQGKIFASVHQTLEQLRRLRAETVVISNGHEALNQATTALPIPEGVPEWLSPLVSILPAQLFTYYLTLARGYDPDHPRTIFKVTRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N5</accession>
    <name>E8N2N5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_08070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559233.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08070"/>
    <dbReference type="EnsemblBacteria" id="BAJ62841">
        <property type="protein sequence ID" value="BAJ62841"/>
        <property type="gene ID" value="ANT_08070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08070"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OMA" id="IFSFYWK"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="280" mass="31731" checksum="7809959199733EA7" modified="2011-04-05" version="1">MRTSAHILERILLYFLLTGMTVLMSFPLLWMISSSLKTLEETNAPGIIWIPAHPTFQAYMRLFQNSDFLRAYFNTVFYTALALTGTLISIAFVAYAFSRVEWPGKNLVFFLMLSTMMIPPQALIVPQYVFFNKLNWVGTFKPLIIPGFFAGGAAMVFLLRQAMAQIPKELDEAAFVDGASHLQIWWEIVMPLMKTPLATVATFLFVGFWNNLLTPLMYLQTVDLYTLPVYVSTLYNINLTVQQWPTIMAAAVLTTVPLMVVFFFSQRFILEGVVVSGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T9</accession>
    <name>E8N2T9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD_synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561430.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30630"/>
    <dbReference type="EnsemblBacteria" id="BAJ65089">
        <property type="protein sequence ID" value="BAJ65089"/>
        <property type="gene ID" value="ANT_30630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30630"/>
    <dbReference type="eggNOG" id="COG1606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_0"/>
    <dbReference type="OMA" id="DKPAQPC"/>
    <dbReference type="OrthoDB" id="846643at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="271" mass="29900" checksum="5F1D3C65E9C9D21C" modified="2011-04-05" version="1">MSTEKIQRLFEILAELDSAIVAFSGGVDSTLVAAAAYRVLGERAVAITAVSESLAESEREETLALARHIGIRHVLIHSHELQDERYRANSPMRCYWCKNELGALLAAYARQHHYSAILDGSNLDDLGDVRPGRKAMQEAGFRSPLIEAGMTKADVREAARLLGLPNWDKPAMACLASRIPFGMQVTRENLRQVEQGEAFLRSLGLRQVRLRHHGRVARLEVEESGFALVLQHREAITARLKEIGFSHVALDLAGYRQGSLHTALESAQSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N326</accession>
    <name>E8N326_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561517.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31500"/>
    <dbReference type="EnsemblBacteria" id="BAJ65176">
        <property type="protein sequence ID" value="BAJ65176"/>
        <property type="gene ID" value="ANT_31500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31500"/>
    <dbReference type="HOGENOM" id="CLU_1500555_0_0_0"/>
    <dbReference type="OrthoDB" id="12510at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228638" evidence="1">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19289" checksum="21C2C126744AA356" modified="2011-04-05" version="1">MKFRVSLLLFMAFLLLVSACSPAQKTSPSPSTEGYPTMGYQGMEGYAPPENSSFEIPAGNVPAPVPDEGKASLSGVLYQKSHSAVLTKFSLYLTPAQGENRDQPPPILAGPLADKGDIPTTSNEKGEFFFNNLEPGNYFLVVSLGYDYELAVKSLDDATPMLIRLEPNQQLSLGTVIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N337</accession>
    <name>E8N337_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-glucose/GDP-mannose dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_31630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561527.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31630"/>
    <dbReference type="EnsemblBacteria" id="BAJ65187">
        <property type="protein sequence ID" value="BAJ65187"/>
        <property type="gene ID" value="ANT_31630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31630"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_0"/>
    <dbReference type="OMA" id="GHCLPID"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="332"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ65187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="438" mass="47858" checksum="DD18B481A0B30C9E" modified="2011-04-05" version="1">MSTKEQLLEKFQNRTAKVAVLGLGYVGLPLATVFAEAGFQVIGVDLVPEKVEKIRRGESYVLDVPSETVAALVKAGKLDATTDFSVCREADAVSICVPTPLRKTGDPDLSYIISATDGLAPYVHPGMVVVLESSTYPGTTREMVLPRLTGASNLKAGEDIFIAFSPERVDPGRKDWTTKNTPKVVGGITENCSDVAAAWYAQALDTVVRVSSTEVAELAKLLENTFRMINIGLVNELAIMCDRLGVDVWEVIDAAATKPFGFMKFTPGPGLGGHCIPIDPLYLSWKMKALNYNARFIELASEINTNMPRFAVGKVQDALNDRGKPVKGSKILVLGVAYKPDIDDMRESPALDVIHLLQQKGAEVRYHDPYIPHFQHDGWEMRSEPDLMSAVRWADAVVIVTNHKVYDYPAILDAAQLIVDTRNALGAAGKNHPRVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N353</accession>
    <name>E8N353_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase chain E</fullName>
            <ecNumber evidence="7">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoE</name>
        <name evidence="7" type="ordered locus">ANT_08330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559259.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62867">
        <property type="protein sequence ID" value="BAJ62867"/>
        <property type="gene ID" value="ANT_08330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08330"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_0_0"/>
    <dbReference type="OMA" id="HIIRYCD"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="19746" checksum="C266E10070293ADD" modified="2011-04-05" version="1">MNELLQNYPEEVKQILAKYPAEYKRSAVMPLLYLAQRKEGYVPRQALEDIAEILEMSPTEVASIVGFYTLYYDQPAGRYHIQVCTDLPCALRGADKFLEELCQRLGIREGETTPDGLFTVEAVKCLAACHRAPVFQVQGDGEIEYHENQTVELTLAWMEQVREKVRAEKEAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A0</accession>
    <name>E8N3A0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559306.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08800"/>
    <dbReference type="EnsemblBacteria" id="BAJ62914">
        <property type="protein sequence ID" value="BAJ62914"/>
        <property type="gene ID" value="ANT_08800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08800"/>
    <dbReference type="eggNOG" id="COG4257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548192_0_0_0"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="434"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="497" mass="55020" checksum="496C72AA492FF967" modified="2011-04-05" version="1">MPFDAQLFLKRVKPSPSGKSIGCFHEKGRTVQLRMLIFIVLIIGLSACTQANPLSAMLVTPAMPVESTNTLPVPSPTMETSVSPAFTPSPTPSPAEWVWTANPINGNLLVIDPSSNSIAVIIPTGFHPEEIAIGEGAVWALDRSADRVLRFNLTTYQMEAVIPIPQGKTMALASGEGGVWVGIEERPLSNVLRPYEEYIPNGGVIRIDPRINQVNGYAEVGSVSRLTTGLGYVWALTRNTVDTPLYRIDPQSLQREEITLHGTHDWLMEDAFHADDKSLWLFSQAFARLYRMNPDGRLYSVFSLRQQKPIGYADLRLAYGSLWFATPWGDVLQLDPSTGAERSRTSLRVPLRSITAGAGAIWVHAPADGAVYRLDSFTGEVQARIEIGEKVPPTPVVTATPIQRATKPCEDAPYSRLQVGMRAYTFKEPDLPQRLHKEPGKESERVGWIQPGETVTVLEGPMCAEGWVWWKVRTERGGYTGWAAEGDENEYWLNPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B9</accession>
    <name>E8N3B9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_08990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08990"/>
    <dbReference type="EnsemblBacteria" id="BAJ62933">
        <property type="protein sequence ID" value="BAJ62933"/>
        <property type="gene ID" value="ANT_08990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08990"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="OMA" id="FPGRDWW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="31542" checksum="AFB21AED8243DDCC" modified="2011-04-05" version="1">MSVVNPAVNARRILGSVPAYFFLTLGLLLAVLPFMLIFVTALKSPGELGNAFALPQQLHWENFLRAWTQAHFGTYFKSSLIVTLSVVGVSCLLSLLTGYAFGQLRFPFKNGLFFLFLIGLMVPTEAYIIPLYYSLRAAHLTDTYWALILPQIGMSVCFGSFWMRGFFSGIPRDLVDAARVDGCNDWQAFWHVMIPMVLPGLWTMAVLFFIWTWNDFLLALVMITKEGLRTLPLGLAMFQGKYTTDYTLTAAGATIVALPTLLFYVLFQRQFIRGVTAGAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C2</accession>
    <name>E8N3C2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_09020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559328.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09020"/>
    <dbReference type="EnsemblBacteria" id="BAJ62936">
        <property type="protein sequence ID" value="BAJ62936"/>
        <property type="gene ID" value="ANT_09020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09020"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057648_0_0_0"/>
    <dbReference type="OMA" id="GFHYYET"/>
    <dbReference type="OrthoDB" id="926014at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="171"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="400" mass="44894" checksum="E059AFD66052FEB6" modified="2011-04-05" version="1">MSLLTRFKQAPQNLKIFATVSLLAGMAYSIYDSTFNNFLESRFSLTGFQRSFLEFPRELPGFLVVFVSALLWFLCSRRLSAFSFLLSAIGALLLGYFTTSYAVMSIWLFIYSMGMHLFLPLSPTIGMELAHEGQTGRRLGQLNAIRNFAAILGSFLVALGFRFLNFNFKITFTIVAVALFLATLLMLLMDRGRPQPSGVFLKLHKEYRLYYALVVLYGSRKQIFVTFAPWVLVSIFQQPTQLMGTLFTIGGIIGIIFQPFLGWLIDHYGERFVLTAEAVLLAFVCIGYGFSRSFLPENLALLLTIICFLLDQMLMSVSMARATYMRKIAKSPEHVQTTLTAGVTIDHVFSISVALLGGVIWNAFGYQYVFLFGALIAVLNFIVARQIRLPGRETVPVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F0</accession>
    <name>E8N3F0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09300"/>
    <dbReference type="EnsemblBacteria" id="BAJ62964">
        <property type="protein sequence ID" value="BAJ62964"/>
        <property type="gene ID" value="ANT_09300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09300"/>
    <dbReference type="HOGENOM" id="CLU_1607456_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="165" mass="18854" checksum="2759C56CB9480274" modified="2011-04-05" version="1">MDCEIGRFVYRINPGNSSRYGELNMFAKIVILGFALLEFSNVLALYFFPASRRANAVGVFSAWEKSRQYPEIHDFVQYLVYWVAGAKLIFIFLLVGIAIFGDANLQRVSLIALALATLSFYWRLFPLIRKMDQNGQITPRNYSKTLGMMIFSLIILFLIAALISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G7</accession>
    <name>E8N3G7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ordered locus">ANT_09470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559372.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09470"/>
    <dbReference type="EnsemblBacteria" id="BAJ62981">
        <property type="protein sequence ID" value="BAJ62981"/>
        <property type="gene ID" value="ANT_09470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09470"/>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038561_0_1_0"/>
    <dbReference type="OMA" id="ILWQGEL"/>
    <dbReference type="OrthoDB" id="1300262at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="88"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="32176" checksum="B05D0444C129CA14" modified="2011-04-05" version="1">MTDLLDQIYFLFERLTWMSVLDIALVTLIIFIVLIMVRETQAVILLRGVILLVIFLSLLTSLVNLPAFSWLIRTIMPALLLAIPVIFAPEIRRGLERLGRAGSSPILGKMRAYPGLEDTIHAIVTAAIRLSNRGHGALIVIQRNDPLEEFISTGVALNARVTPELLLQIFYPNTPLHDGAAIIVDNQIAAAACVMPLSSSGILNRSPERQMGLRHRAALGISEATDAIAVVVSEETGLISLAHNGRMIRRLDGERLENILMAFYLPSQPPPTFLDWLRGWLGQNRPREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K4</accession>
    <name>E8N3K4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">punA</name>
        <name evidence="6" type="ordered locus">ANT_09840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559409.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63018">
        <property type="protein sequence ID" value="BAJ63018"/>
        <property type="gene ID" value="ANT_09840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09840"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_1_0_0"/>
    <dbReference type="OMA" id="EGVYAQF"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="30502" checksum="5ED811EC6C56891E" modified="2011-04-05" version="1">MPEFFSLQEIDEAAQSIRQRLKAQPSVGLVLGSGLGGLADQVQNAVYIEYATIPHWPVSTVPGHAGRLVIGELAGKIVLVQQGRAHFYEGYSMAEVTLPVRVMRRLGIETVILTNAAGAIHPEFEPGDVMLITDHLSLIGMTGFNPLRGPNLEELGPRFPDMSQVYDRELMQLTREEAQKAGIALREGVYVGLSGPSFETPADLRFLRLIGADAVGMSTVPEAIVAKHSGMRVLAFSGISNKANLDGNTITTHEEVLEAGKQIVPKLETLITRVLQRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N8</accession>
    <name>E8N3N8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsH</name>
        <name evidence="7" type="ordered locus">ANT_10180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559443.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63052">
        <property type="protein sequence ID" value="BAJ63052"/>
        <property type="gene ID" value="ANT_10180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10180"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_0"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="15362" checksum="E7176E8C5B49556E" modified="2011-04-05" version="1">MSVNDPIADMLTRIRNGIMAGHAMVAMPSSKIKVEIARILKEEGYIEDYEVAEEAENSARKVLRLKLKYVGERRQRKPVITGLERVSKPGRRIYTPKSEIPWVLSGMGIAILSTPKGVMTGQQARKLGVGGEILCKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S6</accession>
    <name>E8N3S6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_10560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559480.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10560"/>
    <dbReference type="EnsemblBacteria" id="BAJ63090">
        <property type="protein sequence ID" value="BAJ63090"/>
        <property type="gene ID" value="ANT_10560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10560"/>
    <dbReference type="eggNOG" id="COG2983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109769_0_1_0"/>
    <dbReference type="OrthoDB" id="1653862at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00676">
        <property type="entry name" value="UPF0260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008228">
        <property type="entry name" value="UCP006173"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37421">
        <property type="entry name" value="PTHR37421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006173">
        <property type="entry name" value="UCP006173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="147" mass="17230" checksum="AFF69AC852931C32" modified="2011-04-05" version="1">MLEPEFWKKKSLEEMNQEEWEALCDGCARCCLYKLQDEETGEVFYTNVVCRLLDVERCRCTAYSERSSLMPTCLVLNPRQARELKWMPQTCAYRLLAEGKPLEWWHPLVSGDPNTVHLAGISVRYRVIEEKDADMEDLESYVVDWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N421</accession>
    <name>E8N421_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559573.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63185">
        <property type="protein sequence ID" value="BAJ63185"/>
        <property type="gene ID" value="ANT_11510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11510"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033063_0_0_0"/>
    <dbReference type="OMA" id="HVLARPH"/>
    <dbReference type="OrthoDB" id="1841091at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="498" mass="56950" checksum="B80594C39D874AEA" modified="2011-04-05" version="1">MKRLIGWFFPSMKVLLGLMFFLAVLSMGERMMNVDGDLGRHLTIGNFILDTGWIPNRDVFSHTMAGEVLTPHEWMAQVVFALMERWFGLAGVVWLCALMVALTVMLVFRLSWERSGGWLSSLLVTLLAMAASSLHWLTRPHLFTFLFLAIWLKGLEDLFQRKRYGLLVLPVLMLIWANTHGAFLAGFVVWVVYGVGILWRTWVEKTPFTSLSGVFRDWFWVGGLSLIASLLNPSGVDLWKTSVGYVRNAYLVGHTAEYLSPDFHTPGAFPFLLMVLGILGVWGISHQKPRVDEVLLVSLWIAMALYSARNIPLFAVVSAPVLAKSIHTAFQEWAESVPWFKKLRDLDLRMHAVDSKAGGWVTFLLIVVFMAWTARAGLIPARFQSEVFPVRAMDWLEAHPQEGNVFNYFPWGGYILYRAFPDIRVFIDGQTDFYGEALTREYEQVITLQDGWKDVLDKYRVQWALMPESSMLSKALERELNWEVVYRDQVSVILHCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N443</accession>
    <name>E8N443_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">plsX</name>
        <name evidence="5" type="ordered locus">ANT_11730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559595.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63207">
        <property type="protein sequence ID" value="BAJ63207"/>
        <property type="gene ID" value="ANT_11730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11730"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_0"/>
    <dbReference type="OMA" id="HGKSNAR"/>
    <dbReference type="OrthoDB" id="631784at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="337" mass="36193" checksum="AC0026E4523A2504" modified="2011-04-05" version="1">MPIVLDAMGSDRYPDPEIEGAITAALELGEEIILVGNEEIVRPKLEKANTRNAPVRLVHAPDVLEMTDKPVEGARKKPRNSMAVGMELIKSGEASAFVTAGNTGGANFIALRTLGRIRGVSRPPLTAVFPTRKGFCVVCDIGANVDCRPEFLVEFAVMGSIYAQKMLGIERPRVGLLSNGEEASKGNQLVHDTYPLLEKTRLNFIGNVEGKEIFQGDVDVVVTDGFVGNVMLKSVEAVSKLLIDMLTEQIKSSPITMLGGLLAKPAFRKLKKMMAPDEVGAAPLLGIDGLVFVGHGRSNARAIYSALKLAHQAVQKDLLGALRDAIQQELSSTPPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N492</accession>
    <name>E8N492_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ordered locus">ANT_12220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559644.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63256">
        <property type="protein sequence ID" value="BAJ63256"/>
        <property type="gene ID" value="ANT_12220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12220"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_3_1_0"/>
    <dbReference type="OMA" id="SVFECEV"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="96" mass="11137" checksum="A23C807B037C4EBF" modified="2011-04-05" version="1">MMVLITYDVNTETDEGKKRLRKVAKACQDYGQRVQNSVFECVIDPARLRILQAKLEKLIDKKKDSLRYYYLGDEWKNRVEHVGAKPSFDLTGTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A8</accession>
    <name>E8N4A8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative [LysW]-aminoadipate semialdehyde transaminase</fullName>
            <ecNumber evidence="2">2.6.1.118</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argD</name>
        <name evidence="2" type="synonym">lysJ</name>
        <name evidence="4" type="ordered locus">ANT_12380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + [amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:41952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9714"/>
            <dbReference type="Rhea" id="RHEA-COMP:9715"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:78501"/>
            <dbReference type="ChEBI" id="CHEBI:78526"/>
            <dbReference type="EC" id="2.6.1.118"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.118" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559660.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63272">
        <property type="protein sequence ID" value="BAJ63272"/>
        <property type="gene ID" value="ANT_12380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12380"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_0"/>
    <dbReference type="OMA" id="GMTTQIY"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02084">
        <property type="entry name" value="LysJ_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037537">
        <property type="entry name" value="LysJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="385" mass="41823" checksum="D15865E23B48BDE8" modified="2011-04-05" version="1">MMNIIELENQYTSGLYTKRPIAIVRGKGARLWDAEGKEYIDCVGGQGAANIGHANPAVAAAIAAQAQTLISCPEMFYNDRRALLEQRLCEISGFPRVFLCNSGTEANEAAIKFARLATGKSQIVACMRGFHGRTMGALSATWEKKYREPFEPLVPGFQHVPFNRPEALEEAIRENTAAFVVEIVQGEGGVNPASTEFLIRAEQLCRERGALLIVDEVQTGFGRTGKMFAYQHHPIRPDLVCLAKSIAGGFPMGAVLIGEAVGELPPQVHGSTFGGNPLACAAALASIDYMLAHHLPQRAQELGTWFLQALSQIQSPLIREVRGLGLMAGVELKQKVTPYLQALMQEGVLALPAGLTVMRFLPPLVIEPADLEIVIEVLQRVLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F2</accession>
    <name>E8N4F2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559704.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12820"/>
    <dbReference type="EnsemblBacteria" id="BAJ63316">
        <property type="protein sequence ID" value="BAJ63316"/>
        <property type="gene ID" value="ANT_12820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12820"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_867775_0_0_0"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="320" mass="36143" checksum="480DF5323F5EF55B" modified="2011-04-05" version="1">MKVFFRQSGVGLILLGVLVALFHWSYPGYAGTLSQGESCHVLEGEVLEFYNNISNASFILGEPITDLFDNPLKPSEKIQYFQRARIEYSPDLPAGKRVRLSPLGSLNFENLPPAELPLSPGACRLFPTGNSVCFDFLEFYDRYGGQEVFGLPISNLLKLPNNRLVQYFENARFEWWPELPSGMRVHLTDLGRMDFYRNKFPIELLNCKLDLEIISRKPIKPRVMAFPAKIAIQPSEIQTIYIVVRDQNLNPLENIPVSLQVVVEGKTTDPVRLKETDSTGLSLGAIPLGNYKPGTKVEVVVTAMVQDKTVTSRTSFLIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N2</accession>
    <name>E8N4N2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559780.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63396">
        <property type="protein sequence ID" value="BAJ63396"/>
        <property type="gene ID" value="ANT_13680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13680"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053687_0_0_0"/>
    <dbReference type="OMA" id="REWIATP"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="136"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="362" mass="40331" checksum="D12095DA366BC12D" modified="2011-04-05" version="1">MDEIALKLSNLRTLLAQCGLDGILLRKASSFSWLTGGLSSVINTASSFGEASLLVTQEHAYLVTNTIEAPRFLEEDRVENQGWKIILQDWFSSESPLNTMTRGWRLGSDFPTPGFTDLSLEIARLRSILSPEEQNRLREVSSLCAQAMAEAAFAVRPGMSEYEISAVLAHACLNRGVEPIVRLIATDERIFRYRHPPATSKTLQRYAMLVLCGRKYGLVVSLTRLIHFGKLPDEIQRKARATAYVDAIALSATRTGRTLGDVFKDITLAYETTGYPDEWKLHHQGGPAGYEPREWIATLESQERVVSGQAYAWNPSITGTKSEDTILVKEEGFEILTEISAWPTLEIEVSGTLIRRPAILEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Q4</accession>
    <name>E8N4Q4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559802.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63418">
        <property type="protein sequence ID" value="BAJ63418"/>
        <property type="gene ID" value="ANT_13900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13900"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663325_0_0_0"/>
    <dbReference type="OMA" id="RWVNQTA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="414" mass="46776" checksum="50EAD563AAD4FDBD" modified="2011-04-05" version="1">MTTPDPTTQAVEVHHLYEISRIVTQSTDWNSALDQIVPLLRSIFIFDNLAVYLADPFHHTLDVMFARAVGRGRSAEADIAWGENIANQIMDHPEVKIIEPATVSAQNRLASPYILGIPLQAGERTLGVLVLIRFGGPPFNQAYIHLAQFIAQQISLLVERQNLQKAYDLLEAQSKESRVQEDFISTITHELRTPLGFIKGYTTTLLRSDTEWDPQMQQEFLKIIDQETDRLQELIENLLDSARLQSGTLKMIFQPVRLDSLVRSTIEHLRMHHPTFTAHLETDTPLSPIEADPKRINQVLENLFHNAIKYAPGSDVWVKIKEQDGEITLTIEDHGPGIPQRYLPFVFERFFRNPDASPNIHGTGLGLFICKKIIQAHHGNIQVNSIQGKGTTFIIRLPLHQPKGGDFGELSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R4</accession>
    <name>E8N4R4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_14000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559810.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63428">
        <property type="protein sequence ID" value="BAJ63428"/>
        <property type="gene ID" value="ANT_14000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14000"/>
    <dbReference type="eggNOG" id="COG1933">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133669_0_0_0"/>
    <dbReference type="OMA" id="YGECANC"/>
    <dbReference type="OrthoDB" id="1826236at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="183" mass="20741" checksum="17D1841DDBD1E66E" modified="2011-04-05" version="1">MTVDPVFLSNFLLISVGFTAAFLAALWLSLIFWVFRDIRRRTRDTLVHILAVLVVAILFLPGMLIYFILRPPKTLEEEFQQSLEEEALLQTIEESLLCPGCGRKVKEDWVACPACYTRLKKTCHQCGKPIELSWNLCPYCGTPAPGMRRETLSIDDAMRNLVMESELKSSTEPVSSSEDPDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S0</accession>
    <name>E8N4S0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative molybdopterin synthase sulfurylase MoeB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moeB</name>
        <name evidence="5" type="ordered locus">ANT_14060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559816.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63434">
        <property type="protein sequence ID" value="BAJ63434"/>
        <property type="gene ID" value="ANT_14060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14060"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_1_2_0"/>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="291"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="41477" checksum="69353BFD62E8E8AA" modified="2011-04-05" version="1">MATLSQAEILRYSRHLVLPEVGLEGQRKLKDARVLIVGTGGLGSPISLYLAAAGVGTLGLVDYDVVDETNLQRQIVHSTSHVGIPKVESAKRRLLDLNPYIHVETYNVVLRSENARPIAERYDILVDGTDNFPTRYLLNDLAVLTNKPYVYGSIFRFEGQVSVFDARVGPCYRCLFPEPPPPGMVPSCAEGGVFGVLPGIIGALQATEVIKLILGIGEPLAGKLLLVDALDSTFQTVQLRKNPQCKLCGETPQIRDLVDYEEFCGVPAAGRHEIQGIPELSPKEASELLASGEPWALLDVRDPVELQVSKLPGAVVIPVGQLPARLQALNRDRKWVVFCRTGERSARAVKLLRSVGIQAYNLKGGINAWADEVDPTLLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T2</accession>
    <name>E8N4T2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_14180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559828.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63446">
        <property type="protein sequence ID" value="BAJ63446"/>
        <property type="gene ID" value="ANT_14180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14180"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_6_2_0"/>
    <dbReference type="OMA" id="GWTFHGH"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="7">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="289"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="8">
        <location>
            <begin position="432"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="509" mass="57799" checksum="C80ECEDCC4610F32" modified="2011-04-05" version="1">MIQPFSSDLKRILQVVSRASDDVPVYLVGGAVRDHLLGVESHDLDFCLNASPIPLARRVANALNAGFFLLDEQRETVRVVVHEPDGSINYLDFARFREDSLVEDLWKRDFTINAMALPVQEDSILLQLIDPCGGLQDLRDKRLKACSDSAFEDDPVRVLRLIRFAQKLRFHIDPQTLQDARSSVPSLERVSAERKRDEIFQILESPGARVGVDLLDRLKVLPVVFPELEKLKGVKQSTPHVHDVWRHTLETVSRLEILLNVLAEDLSEQSPAGMMVAQASLWLGRYREQFHAHLNRRLNPLRLLRGLTFFCALFHDVGKPDTAFQDKEGRIRFFGHEELSASLAVSRAQALALSHDEVEHIQKVITGHMRIHWLVSEGQPPSPRAIYRFFRDLGEAGVDVCLLSLSDLWATYSHTLTQEQWVSELKVCRALLEAKWEKENILITPPVLIKGGELIRELGLQPGPLIGQTLEAIREAQVEGMVLDKQSALAFAREWINKSFPQQKEERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V7</accession>
    <name>E8N4V7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LPPG:FO 2-phospho-L-lactate transferase</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559853.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63471">
        <property type="protein sequence ID" value="BAJ63471"/>
        <property type="gene ID" value="ANT_14430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14430"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055795_0_0_0"/>
    <dbReference type="OMA" id="DLDTVMY"/>
    <dbReference type="OrthoDB" id="1079756at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="317" mass="34629" checksum="36B476C361DAB470" modified="2011-04-05" version="1">MKVVALAGGVGGAKMADGLARVLPAEDLTIIVNTGDDFNHFGLRICPDLDTVCYTLAGLANSLTGWGRSEETWNALDSIRRLGGPDWFQLGDKDLGTHLERTRRLSQGEPLSKIVRDFSHSWGIAPLVLPMSDQPVETWVETQEMGWLPFQEYFVAQQCQPRVKKFAFKGVEQSLPAPGVLDALEQADCLVICPSNPWVSIAPILNVPGIKESCEGICVRVAVSPIVGGKAIKGPAAKMYEELGIAPSVLAVAESYRGLIDGLVIDAVDNSCRDELEAMGIHVLVTKTVMQDYIDRMNLAKETLEFCQKLMLYKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N518</accession>
    <name>E8N518_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XdhC_CoxI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63532">
        <property type="protein sequence ID" value="BAJ63532"/>
        <property type="gene ID" value="ANT_15040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15040"/>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041115_1_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="190"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="37993" checksum="A59CE05E9EF593D1" modified="2011-04-05" version="1">MYAMEISRRVILELKDKTDFVIATIVAHQGSTPRSTGTKMLVFPDGRTAGTIGGGVLEAKVIERCLVRLNQLKGELQSYQFTGKDAASMDMICGGEVLVLITCVPKSDSEFFNVQQTILTWEEKAQNFVEIIGLQDNGDCLYGGKNLSTSEEIGWIPQTSDVSIEAKTKFMTISGVSVFLEYHEPQTTAYIFGAGHVGQAIALFAKPVGFRVVVIDDRDEFANPDRFPQADEIIVTSSITDIFRERKFKTTDYIVIVTRGHLQDYQVLEQALQTDAGYIGMIGSRRKNYLIFQSLREKGLPEEKLQQVHAPIGLPIGAETPEEIAISILAEMIQHRANHRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N598</accession>
    <name>E8N598_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_15860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559992.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15860"/>
    <dbReference type="EnsemblBacteria" id="BAJ63612">
        <property type="protein sequence ID" value="BAJ63612"/>
        <property type="gene ID" value="ANT_15860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15860"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_249441_0_0_0"/>
    <dbReference type="OrthoDB" id="612537at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018746">
        <property type="entry name" value="DUF2298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10060">
        <property type="entry name" value="DUF2298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03662">
        <property type="entry name" value="Chlor_Arch_YYY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1167"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1264"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1323"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1402"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1445"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1492"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1524"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1560"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="114"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1751" mass="200487" checksum="A63E4A4604A2E0EE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N599</accession>
    <name>E8N599_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63613">
        <property type="protein sequence ID" value="BAJ63613"/>
        <property type="gene ID" value="ANT_15870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15870"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387169_0_0_0"/>
    <dbReference type="OMA" id="MAMRENL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="713" mass="81512" checksum="A5C5D46EF11DD447" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B0</accession>
    <name>E8N5B0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560004.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63624">
        <property type="protein sequence ID" value="BAJ63624"/>
        <property type="gene ID" value="ANT_15980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15980"/>
    <dbReference type="eggNOG" id="ENOG502ZFAN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_770837_0_0_0"/>
    <dbReference type="OrthoDB" id="2056645at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="359" mass="39133" checksum="FCDE7D777BDDF1F1" modified="2011-04-05" version="1">MEKISELLKRPLVIGIVAFLLGTIFGLVVLGWGVWPVQWVDASAKELREDLREDYLRMAIDSYTINKDINLAKQRLNELGDKAKETLDKIKKDNRSQDAGAIGEFDKILQGQLGPGTGSVSPESQATPLEGTQVSETQEPVAAVTPTEEKAAAGTRSNLTVVLGLLCLLTLVVGGILAYLFLFKGRGLRSSSDAGVTIPRSQRATSVGYEEEAGEAPLHTFNSYYHLGADLYDDSFSIDSVTGEFLGECGVGISETIGVGDPKKVTAFEVWVFDKNDIQTVTKVLMSQHAYNDPVISQRLASKGEVVLAEPGKHLTLETKTLILEARIVNMEYGKGALPENSYFEEFSLELNVYRKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B1</accession>
    <name>E8N5B1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">topA</name>
        <name evidence="13" type="ordered locus">ANT_15990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63625">
        <property type="protein sequence ID" value="BAJ63625"/>
        <property type="gene ID" value="ANT_15990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15990"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_0"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="70"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="230"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="776" mass="88254" checksum="05BFBD34CAF30B90" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5F1</accession>
    <name>E8N5F1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_16390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560045.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63665">
        <property type="protein sequence ID" value="BAJ63665"/>
        <property type="gene ID" value="ANT_16390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16390"/>
    <dbReference type="eggNOG" id="ENOG5034B2I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1782854_0_0_0"/>
    <dbReference type="OMA" id="ASACFRI"/>
    <dbReference type="OrthoDB" id="1989657at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="145" mass="16400" checksum="16ADCB1CC135978A" modified="2011-04-05" version="1">MSEIKRFTLIKPTVDTPFCIDFNWWAEQGQDPNVFLREYLCAEHQAAFEQNQTVKIDWVDPQTAEVQAVDGLQHVLIQHCAKQPNFITANTSLVDAVFRILLANGNIPMSPVELSREIGKPADLILRTLSSGRVFMGIRPKHPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G4</accession>
    <name>E8N5G4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560057.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16520"/>
    <dbReference type="EnsemblBacteria" id="BAJ63678">
        <property type="protein sequence ID" value="BAJ63678"/>
        <property type="gene ID" value="ANT_16520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16520"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372418_0_0_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="390"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="475"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="746" mass="84737" checksum="C5D67A8745AEEA26" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S9</accession>
    <name>E8N5S9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_17670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560171.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63793">
        <property type="protein sequence ID" value="BAJ63793"/>
        <property type="gene ID" value="ANT_17670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17670"/>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_0"/>
    <dbReference type="OMA" id="STNPCPC"/>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="211"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="507" mass="55024" checksum="A60D6C73556473B1" modified="2011-04-05" version="1">MLARVYSCAVIGLDGVLVEVEVDTGPGLPGMVIVGLPDTAVQESRERVQSAIKNTGLLFPRKRVTVNLAPASVRKEGPAYDLPIALGVLAASEQIPVEAFEGSLVIGELSLDGSVRHVRGVLPMAAVAREQGISRVFVPKADAAEAALLPNLEVIPVESLAELVAHLKHTISIPPHPPTQPENIPIEVATDFSEIKGQEHVKRALEVAAAGGHNLLMIGPPGSGKTLLARALPAILPQMTIDEALDVTRIYSVADQLPEDIPLIRSRPFRAPHHTISHAGLVGGGNQPHPGEISLAHRGVLFLDELPEFGSRVLEVLRQPMEDKIVTISRAQGSLTFPANFQLVAAMNPCPCGYYGDPVKPCTCSPGTVVKYQKRISGPLLDRIDIFVSVPRIDYEKLSDRRAGESVESVRERVEKARRLQRQRFEASNGTSCNAEMRPAEIRKYCTLNSAASNLMKTAMVQMDLSARAYHRILKLARTIADLADSEEIQPIHLAEALQYRPKDLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V5</accession>
    <name>E8N5V5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system FeS assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560197.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17930"/>
    <dbReference type="EnsemblBacteria" id="BAJ63819">
        <property type="protein sequence ID" value="BAJ63819"/>
        <property type="gene ID" value="ANT_17930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17930"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_0"/>
    <dbReference type="OMA" id="MKLDSMY"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="135" mass="14976" checksum="FE14B11985CD0F0A" modified="2011-04-05" version="1">MDDLYREVIIERYKNPLYKGELEPCDIRFEDENPLCGDHIRIDLRVDDQNRVTEAAFSGHGCAISQASADLLLESIIGKNLDEVKALTKEDVLDLLGIELGPVRLKCALLSLKVLKAGVYGLGENTDGLVGEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N671</accession>
    <name>E8N671_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560311.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19090"/>
    <dbReference type="EnsemblBacteria" id="BAJ63935">
        <property type="protein sequence ID" value="BAJ63935"/>
        <property type="gene ID" value="ANT_19090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19090"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051347_0_0_0"/>
    <dbReference type="OMA" id="HREPYAQ"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="429" mass="49836" checksum="4DB279914412520B" modified="2011-04-05" version="1">MKIAVIGAGLGGMAAAFDLVKAGHKVVIFEASEVVGGLASGFKEPHWSWSVERFYHHWFQSDRAILGLIKELGWQEDVMFRRPKTVAYHQGEFYPLDSPLAALRFPGFQFPWGILRFGLVTFYLRYLAQWQSLENFRAHDWMRQWYGERLYQTLFQPLLEGKFGPHYTEVNMAWMWARLKARTTRLGTFRGGFQVFADRLADHLRSLGVSIRLNTPVTQITKGRERLLKITTTSEEEFDQCLVTSSPAQLARMAPELPEDYLKGLLRLKSMGAVVLVLSLKHQLSRQGYYWFNIPKSAGYPFLALVEHTNYLDPKFFGGDHIVYCGDYLDPDHEYFRLSEEELLSRFIRVFPKFNPDFKPEWINKVWLWRTSYAQPVPYLNHSRNIPSIQTPLKGLFFASMSQVYPWDRGTNFAVEICRKAARLMMDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N674</accession>
    <name>E8N674_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_19120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63938">
        <property type="protein sequence ID" value="BAJ63938"/>
        <property type="gene ID" value="ANT_19120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19120"/>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089926_1_0_0"/>
    <dbReference type="OMA" id="EVNGPGC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="207" mass="23363" checksum="D863E95B2B77E884" modified="2011-04-05" version="1">MINVAEIQVGTRSLGPGWRTVIWVQGCPFHCPGCYSPDWIPDKPAQFYTPEDLFSKAISDHRIEGITISGGEPFNQSQELEKFLHIVRERTSLNVICFSGFTFRQLIQHPSKSVHAMLHLIDVLIDGAYIREKSTDLGLRGSTNQKIYHLTPALIHHDFISAPRVNEIHISNNKILAVGIPTSGIESFMIGEPPWLIQSEVRNHERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D1</accession>
    <name>E8N6D1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63995">
        <property type="protein sequence ID" value="BAJ63995"/>
        <property type="gene ID" value="ANT_19690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19690"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_2_1_0"/>
    <dbReference type="OMA" id="PMNAIPG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="196"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="457" mass="50259" checksum="59D402539B8F9BFC" modified="2011-04-05" version="1">MEVAMSHFARVDAYLQSHLDDSISELSRYCAQPSVSAQNWGLQETAEMTAEMLRQRGFEVKIFPTDGAPIVYGERKGRSPKTILFYNHYDVQPPEPLELWDTPPFEPAIRDGKLYARGVSDDKGHFTSRLFAIDALLAEEGELPCTVKFILEGEEETSSAHLAPFVRSHAELLKADACIWEFGGVDFRDVPMQYLGLRGICYVELSVETANQDMHSGLGGSIMPNAAWRLVWALNSLKGPDEAIRIRGFYDNVRKPTEREIALLEALPDPAEEYKTRYGVKSFLKGLTGGTPLKIAEVYEPTCTICGLTSGYQGPGSKTVQPAKASAKVDFRLVPYQTPEEVLEKLRAHLDAEGFGDVQITFLGGEAPALTDPDDPFVQLVVEAALEPYGQPMQIVPMVGGSGPNHVFIETLKVPVVTAGIGHPGSQAHAPNENIRLDLYLKGAMHIARILKAFGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXE7</accession>
    <name>E8MXE7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560399.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20020"/>
    <dbReference type="EnsemblBacteria" id="BAJ64028">
        <property type="protein sequence ID" value="BAJ64028"/>
        <property type="gene ID" value="ANT_20020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20020"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_16_0_0"/>
    <dbReference type="OMA" id="DQFGIVM"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="87" mass="9953" checksum="C0DECEE6EAA4CD1E" modified="2011-04-05" version="1">MNSIEDLIRTYIAQNILFSSNGFPYPDDASFLENGIVDSMNVLEIVMFVEEKFGIKVEDAEIIPENFDSVTQLASYIRKKQTLMLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG7</accession>
    <name>E8MXG7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560418.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64048">
        <property type="protein sequence ID" value="BAJ64048"/>
        <property type="gene ID" value="ANT_20220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20220"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028014_0_1_0"/>
    <dbReference type="OMA" id="WRYRRWE"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="49115" checksum="AD61F2F44F69287D" modified="2011-04-05" version="1">MKKILVISNNLPFPPKDGGRARIYHLYSRLAKKYQITWVSPIWDGEEENIPGTLRFCHQVIPLPKEEIFSFPSSGWKGLMKRVLAHLHFPRLFEFAFGYVNAPGVYWLPKTPQRLRKIQEILEQNHFDLIISEFEGNAELIPEQITIPRILSTHNVQSHLFWRARKTFPGTWLDRVFLFPEWQKIIHYEKKNYRRYNGILAVSQNDQRTLEKRCPGIPVKLVPNGVDTEYFFPSSSSPVPHTMVYLGNYAYPPNADAVRYFYTRIFPKIRARFPDAKLILIGASPPKELCGEDGVEALGFVEDVRPNVHQAEVMIVPLRTGGGTRLKILDGMAMGKAIVSTTLGAEGLQVIDGENILLADTPDTFAAQVIRIMENAELRQKLEKNGRTLVERLYNWDAIAREAGEWIETFLYQPALLQLQREEMNAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK0</accession>
    <name>E8MXK0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative rhamnulose-1-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rhaD</name>
        <name evidence="2" type="ordered locus">ANT_20550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.19" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560451.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64081">
        <property type="protein sequence ID" value="BAJ64081"/>
        <property type="gene ID" value="ANT_20550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20550"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076831_0_0_0"/>
    <dbReference type="OMA" id="SHFMSHI"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008994">
        <property type="term" value="F:rhamnulose-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="14"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="278" mass="31019" checksum="BBA96533CB3D5CBF" modified="2011-04-05" version="1">MSQTPYFEIESLLEMMGKAGKRLAEMNASEGAAGNLSIGIRGQIIPEELFSIQEQIELPICVPELSGITFLVSGSGQRLRDILDHPLATIGCLQIDDEGKTGTLYTSPQRKFQKLTSEFNSHLAVHAVLMTEKALHFHSIVHAQPPYLTYLSHLTPYQEERTLNQRLFRWQPETIIQFPEGFAVLPFAVPGSDELMRANVTALRRHKLAIWSKHGVMACSEECILKAVDYIEYAEAAARYEYLNLATGAPSAGLSVDEILRICQAFHIKQTVFSKPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP4</accession>
    <name>E8MXP4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyphosphate--glucose phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppgK</name>
        <name evidence="1" type="ordered locus">ANT_20990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.63" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20990"/>
    <dbReference type="EnsemblBacteria" id="BAJ64125">
        <property type="protein sequence ID" value="BAJ64125"/>
        <property type="gene ID" value="ANT_20990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20990"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065796_0_0_0"/>
    <dbReference type="OMA" id="HVEMLFS"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047330">
        <property type="term" value="F:polyphosphate-glucose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="27251" checksum="2279FA1504320BF1" modified="2011-04-05" version="1">MGRQGMEILGIDIGGSGIKGAPVDVETGQLTAERYRLPTPENALPEEVALVVAQIVEHFQWKGRVGAGFPAAIKHGVAQTAANIHPTWIGLHAGNLFSEKCGCPVSVLNDADAAGLAEMIFGAGKGQKGVVLMITIGTGIGTALFTDGILVPNTELGHIEIRGKDAEQRSSEAARQRKDWTWQQWAKRLNEHLERLEALFWPDLFILGGGAVKNHEKFFPYLKLRTPFVAAKLGNLAGIVGAAWYAHTQETQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV6</accession>
    <name>E8MXV6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560557.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64187">
        <property type="protein sequence ID" value="BAJ64187"/>
        <property type="gene ID" value="ANT_21610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21610"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_7_1_0"/>
    <dbReference type="OMA" id="WTERWQA"/>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="95" mass="10574" checksum="69E418A525EDA4DD" modified="2011-04-05" version="1">MTANEVVQVSSNGRITLPSSIRYKVGLSEGDLLRIEVSEEGQIILTPVVALDRTQAYFWTPRWQAGEQEAEADILSGRVRTFSTVDDLFEDLTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW3</accession>
    <name>E8MXW3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21680"/>
    <dbReference type="EnsemblBacteria" id="BAJ64194">
        <property type="protein sequence ID" value="BAJ64194"/>
        <property type="gene ID" value="ANT_21680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21680"/>
    <dbReference type="HOGENOM" id="CLU_2091702_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="116" mass="12657" checksum="C162DFCD5E5E14E6" modified="2011-04-05" version="1">MELCKKFFARFTLQEVDMIAAIVNALVPPVELPAGLWIERAAWADVTAAIEAGTPHYVRHAGTAKLLGKEPNGGFYSPEVGDVYLVVRLKPGTAPRGSEVEAGVEDLEILRVEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY07</accession>
    <name>E8MY07_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_22120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560607.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22120"/>
    <dbReference type="EnsemblBacteria" id="BAJ64238">
        <property type="protein sequence ID" value="BAJ64238"/>
        <property type="gene ID" value="ANT_22120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22120"/>
    <dbReference type="HOGENOM" id="CLU_2340706_0_0_0"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="97" mass="11571" checksum="4D14CF8A267E9797" modified="2011-04-05" version="1">MYATILRGQVSRENWGRLQTEYEKLLLSKPEEVLETFLLQSEDQPNLWQIVTLWRSEKAFRKAVEEKKTEACEALFCDMGSVPERLHFHVRRGFERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYH1</accession>
    <name>E8MYH1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_00820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558514.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62116">
        <property type="protein sequence ID" value="BAJ62116"/>
        <property type="gene ID" value="ANT_00820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00820"/>
    <dbReference type="HOGENOM" id="CLU_1313297_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="6">
        <location>
            <begin position="46"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="209" mass="22754" checksum="2F162455A8C79EAC" modified="2011-04-05" version="1">METEPAKSGKMSWYQVMAQVYSQPSVESYQDVVSCQGIRFSRVYLWIFSSTLLAMLIPLVLYYATGGKIVHDDLKRTFLLGNAGMGIYFAAGVGTALLAPLIFMAGAGILHWLAQRLGGTGHFEPLVFLLGAVYTPGNLLDQLLEGFLPPVLGLVFRLGLLLIMAYLSILSVKAVHRLSWGKAVLVFAIPVLIIALLSGCYLGFLLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY1</accession>
    <name>E8MYY1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24410"/>
    <dbReference type="EnsemblBacteria" id="BAJ64467">
        <property type="protein sequence ID" value="BAJ64467"/>
        <property type="gene ID" value="ANT_24410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24410"/>
    <dbReference type="HOGENOM" id="CLU_3057960_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="53" mass="6291" checksum="203BA088002886D5" modified="2011-04-05" version="1">MDELTPEELDALIAFEAEIREQEERKFEVLYWLEMLPANDPLWAELAERLGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ13</accession>
    <name>E8MZ13_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ade</name>
        <name evidence="8" type="ordered locus">ANT_01220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01220"/>
    <dbReference type="EnsemblBacteria" id="BAJ62156">
        <property type="protein sequence ID" value="BAJ62156"/>
        <property type="gene ID" value="ANT_01220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01220"/>
    <dbReference type="eggNOG" id="COG1001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027935_0_0_0"/>
    <dbReference type="OMA" id="TDHECFT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01295">
        <property type="entry name" value="AdeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="95"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="7">
        <location>
            <begin position="439"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="612" mass="66583" checksum="C21E95E55BB36EA4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ22</accession>
    <name>E8MZ22_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_01310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558563.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01310"/>
    <dbReference type="EnsemblBacteria" id="BAJ62165">
        <property type="protein sequence ID" value="BAJ62165"/>
        <property type="gene ID" value="ANT_01310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01310"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_2_0"/>
    <dbReference type="OMA" id="MVVNIPM"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="438" mass="47630" checksum="F537F36009593057" modified="2011-04-05" version="1">MPTTLSTPKPVSRIPNTFRALRHYNYRVWFIGQTISLSGSWMQTMAQQVLVYRLTGSAAALGFISFIGLIPLIPFSLWGGSLTDRFPKRDVILWAQVVMMAQALLLSWLTWSGRVQVWHIYALSLLLAAVNAVDLPARQAFTVDMVEGKEDLTNAIGLNSAMFNLARALGPALAGLVVAAIGEGPAFFFNALTFVPVILALLSMRNLPQSSRPPQAHSTVRHILEGLRYVISKPVQLLLMSLVAVSAFLSMPYNTLMPVFAQDVLSESAQPVIARVCEGPARLFSCQSPQALPLGMLLTAVGVGAVLGALFVASLPAESHRGRWLTLGNLGFPLALLFVAVSRSFLFSLFMMMAAGWMFVLQNALANTLIQMTAPDEVRGRVMGFYTMTIQAFMRLGALQAGYVADWIGAPLALGMGALLSLLYGGWVALFKPVIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ69</accession>
    <name>E8MZ69_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558610.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01780"/>
    <dbReference type="EnsemblBacteria" id="BAJ62212">
        <property type="protein sequence ID" value="BAJ62212"/>
        <property type="gene ID" value="ANT_01780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01780"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_15_1_0"/>
    <dbReference type="OMA" id="NWLWINP"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228556" evidence="1">
        <location>
            <begin position="23"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="431" mass="45993" checksum="9A305959FA444F77" modified="2011-04-05" version="1">MSKKFWYSLIAVLMLTALVLSACGGAATQAPAQTQPPAQGGKEVEVFSWWTGGGEAAGLEAMIKVFNAKYPDIKFINAAVAGGAGTNARAVLATRLQSGDPPDSWQGHAGQELIGTYVAGNQIQPLNDLYESEGWLKVMPQTLIPLISQDGKIYSVPVNIHRANVLWYNPKILEDNKIAVPTTIDEWFAAMDKLKAAGVTPLALGEQWTKMHLLETILLGTLGAEKYNGLWNGTTDWGSAEVKTALENFQKAMTYANTDSASLSWQDAAQLVVNGDAAFNVMGDWAEGYFRELGKKPKVDYGWAPVPGSVGVFQFLSDSFVLAVGAPDPEAAVAWLKVAGSKEGQEAFNPVKGSICARTDCDKALFGEYLQSAMDDWASNVVVGSLTHGVVANDSWKSEIDTALGLFVSNGDLAAFQSALVNACKSSGPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ75</accession>
    <name>E8MZ75_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">pfkA</name>
        <name evidence="17" type="ordered locus">ANT_01840</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01840"/>
    <dbReference type="EnsemblBacteria" id="BAJ62218">
        <property type="protein sequence ID" value="BAJ62218"/>
        <property type="gene ID" value="ANT_01840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01840"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_0"/>
    <dbReference type="OMA" id="MNTIMEC"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="11"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="28"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="132"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="258"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAJ62218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="35084" checksum="79972A794303038A" modified="2011-04-05" version="1">MIMFKTSLRTIGVMTSGGDAPGMNPAIRAVVRTALANGIRVIGIEDGYEGMLNGRFREMGARDVGGILQRGGTILRTARSMEFKTPEGQRKAIRQLSSAGIDAVVIIGGDGSLTGGMKLQEQGVPVIGIPGSIDNDIYGTDMCVGVDTALNTIVDAIDKLRDTASSHNRAFFVETMGRNCGYLAVQAGIICGAEMAIIPEYETPFKEVAEAVEDAYKRGKSHCIIVVAEGAKLNANELAAKLQEMNVGFDTRVTVLGHVQRGGKPTAFDRFLATRFGVKAIEFLLSGQTGVMTALTGRDITPIPLATVVNNRRTLSEEYIKMARILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZB1</accession>
    <name>E8MZB1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558652.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02200"/>
    <dbReference type="EnsemblBacteria" id="BAJ62254">
        <property type="protein sequence ID" value="BAJ62254"/>
        <property type="gene ID" value="ANT_02200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02200"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_838489_0_0_0"/>
    <dbReference type="OrthoDB" id="2116734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="331" mass="36636" checksum="D0258535D8FB7FCA" modified="2011-04-05" version="1">MKVRLFLTSFFLGILSMFAVWAFQWTLDSWKEITFDLPGEVTVLRLIKRAQGVATADASAVQEKLKAYLRDQSLTLIVSSSGDGRPEIVVYDPHHLVTWFPGCPSEDTHPGGMDAYIFRGTYSEKLWISSLNVPFLPQGAIVRGIISAPHRAGTLQYARCVGGELLPEGQYTFNTADPAQAQQIVRMLYQMGFVAQSNTKLPFYLYLIQNPLMVIPGFFLLAAWGCVLLYWLLYLHGRKREFGIRVRHGALPDDLVWENFLVGLPGLVCGTTLGGLVAGILVAAISQVLLSPAEVLTIVSTIGITFFIVVGVWLATLFVVVRFGYERSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC4</accession>
    <name>E8MZC4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_02330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558664.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62267">
        <property type="protein sequence ID" value="BAJ62267"/>
        <property type="gene ID" value="ANT_02330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02330"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089201_0_0_0"/>
    <dbReference type="OMA" id="AMFPLMF"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="284" mass="31264" checksum="52E7F68368C6BEBC" modified="2011-04-05" version="1">MQTEFGLSQPSWRSHLRALWMIAVNNWKHHWRYPLNAVSDMLQPLVWLAPVYFMGQAFSVNGRAEGFAGFAGTDDYMSYIILGTALTNFIMAVFWGMGFSLKWDMDGGVLEANWMAPLPRPLMLVGRTLSSLATTTLTSLGMILIGALVWGFHPTGNALSAVLVAVPLLIGLYGFGFAFAALVMILREANTLVDSGSYVVMLLSGANFPVTVLPKWLLPLSLALPLTYGFDAVRAILLKTRTLLPLNVEIAILLASMVLMIVIGLRAFYALERRVRQMGTVGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD3</accession>
    <name>E8MZD3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560836.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64481">
        <property type="protein sequence ID" value="BAJ64481"/>
        <property type="gene ID" value="ANT_24550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24550"/>
    <dbReference type="HOGENOM" id="CLU_979240_0_0_0"/>
    <dbReference type="OrthoDB" id="1425664at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015093">
        <property type="entry name" value="DUF1887"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09002">
        <property type="entry name" value="DUF1887"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="306" mass="34404" checksum="D6491F5235A9AAFF" modified="2011-04-05" version="1">MILLTLLGEQPIPNLLPLWQYREFSGVQFVVTPRTRPLAESLAAFIRQDRTLQHLQVHEPLDVEAYDLSQTRLRLIQALMSHIRAHTPVTLNLTGGTKLMSLAAMQAAYGLAVPLLYVSSETGEMILYTSDGIEQKREPIHVSITADQYLQAHGIESSPYQNFAENEKYAPIRSTKEGDWLEEAVYQAALQSGMFDDVRKNVYIRRRGRKDAVINELDVVVTRNGLLGVCSCKSGKKLDKDDLYELEALSSREKFGIYCGKVFACATDEIPEGIKERASADKIRLAFGKDVAQKAVQQLLESLKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG4</accession>
    <name>E8MZG4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560867.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24860"/>
    <dbReference type="EnsemblBacteria" id="BAJ64512">
        <property type="protein sequence ID" value="BAJ64512"/>
        <property type="gene ID" value="ANT_24860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24860"/>
    <dbReference type="HOGENOM" id="CLU_356273_0_0_0"/>
    <dbReference type="OrthoDB" id="234213at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025904">
        <property type="entry name" value="Tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13809">
        <property type="entry name" value="Tubulin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="787" mass="89701" checksum="41A3B04B0BC4B6B2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG8</accession>
    <name>E8MZG8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560871.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64516">
        <property type="protein sequence ID" value="BAJ64516"/>
        <property type="gene ID" value="ANT_24900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24900"/>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_1_2_0"/>
    <dbReference type="OMA" id="VEHALNM"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19455" checksum="14A5CB07C5B04F8E" modified="2011-04-05" version="1">MTKENEEILSLSREVGDLLRQHGWYLVTAESCTGGLVGNWITDIPGSSDYYLGGVIAYANEVKQALLGVSASSLAQFGAVSPEVAREMASGIRHLFSQKFPIEKLVGIGVTGVAGPGGGTPQKPVGLVWIAVEAPQVQRVERFLWQGDRRQNKAFSAYRALSLLKEELLAWEESTHGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH2</accession>
    <name>E8MZH2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_24940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24940"/>
    <dbReference type="EnsemblBacteria" id="BAJ64520">
        <property type="protein sequence ID" value="BAJ64520"/>
        <property type="gene ID" value="ANT_24940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24940"/>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_2_1_0"/>
    <dbReference type="OMA" id="VHMADPH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="4">
        <location>
            <begin position="297"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="332"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="586"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="731" mass="84032" checksum="AFA693E4AE4BEFE9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH3</accession>
    <name>E8MZH3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-phosphoglucomutase</fullName>
            <ecNumber evidence="5">5.4.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pgmB</name>
        <name evidence="5" type="ordered locus">ANT_24950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.6" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560876.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24950"/>
    <dbReference type="EnsemblBacteria" id="BAJ64521">
        <property type="protein sequence ID" value="BAJ64521"/>
        <property type="gene ID" value="ANT_24950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24950"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_0"/>
    <dbReference type="OMA" id="YHGRRPM"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008801">
        <property type="term" value="F:beta-phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02598">
        <property type="entry name" value="HAD_BPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010972">
        <property type="entry name" value="Beta-phosphoglucomutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01990">
        <property type="entry name" value="bPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="111"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups" evidence="4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610972-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="214" mass="23657" checksum="56C996010FC225F4" modified="2011-04-05" version="1">MIRAVLFDLDGVLTDTSEYHFLAWKRLADELGIPFDRQDNEALRGVSRRESLLLLLKGRPATEEDMQAWMERKNRYYVEYISQMTPENLLPGALNLLQELRANGYKTAIVSSSKNTPLVLERLNLAHWIDAVVDGNAPARSKPAPDLFLLAAERLGVVPQECLVVEDAAAGIDAGHAAGMRTLGLGPRERVGHADMVLPDLNGVHLADLKPVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZL3</accession>
    <name>E8MZL3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560916.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25350"/>
    <dbReference type="EnsemblBacteria" id="BAJ64561">
        <property type="protein sequence ID" value="BAJ64561"/>
        <property type="gene ID" value="ANT_25350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25350"/>
    <dbReference type="eggNOG" id="ENOG5032UK4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1583162_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="168" mass="18746" checksum="116613B2EE39F875" modified="2011-04-05" version="1">MSFFETLFERYELPPFILAFVFVAAGLGTAYLLGQVHTLTCERTAERQNCRIDVSWMGILPLRHQTLPRLEGAWVDESCDEDGCTYRVVLQTVSADFPLGVGYSSGKASKEEIVQKIQAFVKNPAQPVLEVKTGGGLWILFPLVFLLTGFWLGISPFLSTLFPVQNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM7</accession>
    <name>E8MZM7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25490"/>
    <dbReference type="EnsemblBacteria" id="BAJ64575">
        <property type="protein sequence ID" value="BAJ64575"/>
        <property type="gene ID" value="ANT_25490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25490"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_859553_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="323" mass="36595" checksum="C3861DAD057515E2" modified="2011-04-05" version="1">MSVLSMSTHPLNPSSANIRTLSHQWQGARLGLLLEWADGSPLTIQPHYWASLCQKAGARYVIFSPSLMESLSEEESTYLTNVLNACIQQNYLTGVSISQTSIPHMPHWEDIGVLRIAWTPPHASQNFSYEAGETLLCNQRQQGKPNFVTFKRDFGEWLAPEAWETLDWLVLDPHTPLRSPMRSLRTLINLLVRAAVRGGNLLLSVPVSAHGVEARHQRRLEQLGNWLNLYGHTLYDTQPGPYPPQLWGGCTWQENRLYVHVLDWVDEEVILPLPSGHIRKITCLTAPSIGIQRTANSLSFRIPPENQQEMDTIIEIELDQPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP0</accession>
    <name>E8MZP0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560943.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64588">
        <property type="protein sequence ID" value="BAJ64588"/>
        <property type="gene ID" value="ANT_25620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25620"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_2_0_0"/>
    <dbReference type="OMA" id="GEHSATH"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="234" mass="25625" checksum="91A242C6428972F8" modified="2011-04-05" version="1">MPVLKFSRVVELSHPIHPEIPQWQGDPPVIFTPHTDIPSSGYFLRAFSMGEHSGTHLNAPASFITGGRGVDEIPAGQLLLPAVVISITEKARANPDYALSLEDITRWEQHHGEIPAGALVLLHTGWSQFWNDPQRYYGLDEQHNTHFPGFDTQCARFLMTQRGAAGLGCDTPGVEPAWDIHFSVNRCIAEHDGLALENLTNLQELPPIGAWVFIGRLALKDGSGSPICVLGLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR1</accession>
    <name>E8MZR1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560964.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64609">
        <property type="protein sequence ID" value="BAJ64609"/>
        <property type="gene ID" value="ANT_25830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25830"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_0"/>
    <dbReference type="OMA" id="QHGKIDN"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="249" mass="27232" checksum="FEEC6D2293A6F157" modified="2011-04-05" version="1">MSHNVLISGASSGIGRATALRFAREGWNVGVLARREPLLRELLGECPAGNHFLCAGDMQDAHTIERLDKLIRTHWGQLHALVNCAGIFTPVDLLEVPLEEWRKSFDTMVNGALRLSQLAVRWMRGGGRIIHITSIHGERAERGASAYSMAKAAINQMCRALALEWADRGILVNAIAPGFVDTPMSVVNGVNELQSEWFQQNYVQGHHLPLRRAAQPEEIAGVAYFLAGPDASYITGQVIVVDGGLTITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS1</accession>
    <name>E8MZS1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560974.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64619">
        <property type="protein sequence ID" value="BAJ64619"/>
        <property type="gene ID" value="ANT_25930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25930"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_556268_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="445"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="490" mass="54667" checksum="63E4F6BB7B422B2A" modified="2011-04-05" version="1">MLWRWLAGGMILFLVVSCSPLPGQGEAVPASPAATASPSLPEVVLTSTPPLPEEILAIVPASQPVQTEEPQMKFWQEPAGCRPSEEQWGETPNEWLAYADSLLGWTRPLAKRALPRIWHPQKKETLPSRDGVYAFDVSDVRPRYLIQQALNALHVAGFAAWLRRDSQGALEILSVPLTPQTLGGVWGEYLQAYWLSPVSSPSGDERIIPTMKLTPCRWMTESGMAPNVPAGTMEQAHWELPDWAEAANAYLAETSEQAYRVAFRINWLGDGENEGPRTMCGPLAWSILYDAQSFPPGYGEWSEGPKTFWLPKPSVNGRPWSLFPSETYLVRRFNEPAGTFDFSQFPLAAGDVLYLYGKGDGFDHVALVTEVDEQGNVYSVTNRVWVEPELRFAIQRMVLYNAHDPTVGILRNEWAKDRINGRTGHGGFEMFRWRWRQKQLNGQTVQIAVEVGDTLPLLAMKWHTPPEQIAAANGLTNDTSLTVGMTVQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY5</accession>
    <name>E8MZY5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ribonuclease D</fullName>
            <ecNumber evidence="2">3.1.13.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.13.5" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558717.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02860"/>
    <dbReference type="EnsemblBacteria" id="BAJ62320">
        <property type="protein sequence ID" value="BAJ62320"/>
        <property type="gene ID" value="ANT_02860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02860"/>
    <dbReference type="eggNOG" id="COG0349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042387_3_1_0"/>
    <dbReference type="OMA" id="FMRVDTF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033890">
        <property type="term" value="F:ribonuclease D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="PTHR12124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="216"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="304"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="43176" checksum="AD30FCE38A5FE805" modified="2011-04-05" version="1">MHHQDPTAPIWVATPTALRRMMNHLLACEQIAVDTESNGLHAYQEQICLIQFSVPGADYLVDPLASVNLSGLNEIFSNPGIEKVFHAAEYDILCLKRDFGFTFTHLFDTMIAARILGRSEVGLAALLEEHFGVTLDKRYQRANWARRPLPPAMLNYARLDTHYLIDLRNHLAKELAERGLTALAEEDFLRVCETPAAPAESRPPMWWDVAGTTDLPPQQASLLQALVEFREQQARFANLPPFRVLSNAVLIQIAEANPMTLEDLAEVQGLSYAHLERYGLGIMEALRRGRTRPAPQPPGYSRPNHQILKRLEMLKRWRKDAGRRMGVESDVILPRDTMHALAQCDVTTPEDIERLMAHLPWRWQTFGKELIQLLVKEKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N031</accession>
    <name>E8N031_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">leuD</name>
        <name evidence="12" type="ordered locus">ANT_03320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558763.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03320"/>
    <dbReference type="EnsemblBacteria" id="BAJ62366">
        <property type="protein sequence ID" value="BAJ62366"/>
        <property type="gene ID" value="ANT_03320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03320"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_0_3_0"/>
    <dbReference type="OMA" id="FEVNGIN"/>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="196" mass="21379" checksum="8334C7E3F495B1C5" modified="2011-04-05" version="1">MQSFTTLTSHVVVLPVNDVDTDQIIPARFLKTTDKNGLGANLFADWRYLPDGSPNPKFVLNRPESQGAQILLAGDNFGCGSSREHAPWALLGWGFRAVISTTIADIFRNNALKNGLLPVVVSPQAHARLMALYAAQPSLPLTIDLPSQTLRLADGSQESFPIDSFSKTCLLNGVDELGYLLSLEAEIARYEQSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N043</accession>
    <name>E8N043_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_03440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558775.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03440"/>
    <dbReference type="EnsemblBacteria" id="BAJ62378">
        <property type="protein sequence ID" value="BAJ62378"/>
        <property type="gene ID" value="ANT_03440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03440"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046133_0_0_0"/>
    <dbReference type="OMA" id="VKDYFFT"/>
    <dbReference type="OrthoDB" id="1223448at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225184" evidence="2">
        <location>
            <begin position="29"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="13"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="458" mass="50708" checksum="03D0DF8683CD54C8" modified="2011-04-05" version="1">MHKIRRWLPLMLLFLLGAVMLFSQPVQAQGQKVILYFFWGDGCPHCARMKPFLEELEKRYPDLEVRRFEVWHDDENLKKFQKMIDAYQIQGAGVPTTFIGDRYWVGYNEQIGAEVEEAVKACLQTGCKDAAEGILTPVENPSTEKPAPRPAIDPNNPSVINLPILGQVDLKSQSLLVSTLLISFVDGFNPCSVWVLTMLLALTLRTGSRKKIVIIGLVFLTVTAGIYALFIAGLFTVFNIISFVGWVQVIVALVAIFFGAVNIKDYFWYKEGISFTIADEKKPGIARGIRRVLDAGDNFWAMVGGTVVLAAGVSLVEFSCTAGFPVLWTNLLTAQKVTALTFVALLLVYMIIYQLDELGIFFAAVFTLKASRLEEKEGRILKLIGGTLMLALAGVMLINPALMNDLGGAVIVFLIAFAVAGLILLVHRVILPHYGIWIGTEAEGRKRAAARRARSKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N092</accession>
    <name>E8N092_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560995.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64641">
        <property type="protein sequence ID" value="BAJ64641"/>
        <property type="gene ID" value="ANT_26150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26150"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_3_0"/>
    <dbReference type="OMA" id="QETDFFL"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="210"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="401" mass="45677" checksum="E4163556CF6C34EA" modified="2011-04-05" version="1">MKGKVLLVVPVFPQPSETFIVNHFSGLLEKGWNVHLLCGRINRSAISHYQEVYPKFHGRIHTLLPVHPAVLAFFLFPFILLFSLCFSPGLMVRYFRFSPAKSIWEKVKQFYLDFPVLWLNPDILHFEFGYQVVGKSFLKSVLNCRLVVSFRGHDLDFWNLDAPDAYRVDCSRVDAIHVLSEALRQKALQRGCPENSVFWRIPPAVNPADFKPNGTRKNAEFFNILSVGRLHWVKGYEYALSAIAILKQQQIPVRYCIIGDGEFRPALEFAVHQLGLQDCVTFLGKQSQDVIRRELEKADVFLHPAVEEGFGNAVLEAQAMEVPVVCSDAVGLPENVQDGVTGFVVPRRNPQLLAEKLIFLLQNPQARIEIGRAGRQRVLECFSLEQQKEAFDRMYSSLFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B8</accession>
    <name>E8N0B8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphorylase</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561021.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26410"/>
    <dbReference type="EnsemblBacteria" id="BAJ64667">
        <property type="protein sequence ID" value="BAJ64667"/>
        <property type="gene ID" value="ANT_26410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26410"/>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019054_0_0_0"/>
    <dbReference type="OMA" id="IEDACSD"/>
    <dbReference type="OrthoDB" id="136681at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="796" mass="90777" checksum="EB48B20D2566C81E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H7</accession>
    <name>E8N0H7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_27000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561078.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27000"/>
    <dbReference type="EnsemblBacteria" id="BAJ64726">
        <property type="protein sequence ID" value="BAJ64726"/>
        <property type="gene ID" value="ANT_27000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27000"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_9_3_0"/>
    <dbReference type="OMA" id="TNRPAVM"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="25"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="15654" checksum="E6CC809EC983FF56" modified="2011-04-05" version="1">MAEETKSIEIKKETPLAEEKTERIRERRVYLPRTDIYETRDDLVLVMDLPGADEKSVDIMLEKNVLTIKAYPTFERPENYTLAYAEYGEGDFERSFALSDEIDREHIEARVKNGTLYLRLPKAGAAKPTKIEVKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J9</accession>
    <name>E8N0J9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561100.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64748">
        <property type="protein sequence ID" value="BAJ64748"/>
        <property type="gene ID" value="ANT_27220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27220"/>
    <dbReference type="eggNOG" id="COG5465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118111_0_0_0"/>
    <dbReference type="OMA" id="WPRTING"/>
    <dbReference type="OrthoDB" id="1243140at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="17477" checksum="72C4B52A878F70B4" modified="2011-04-05" version="1">MKTILSVLEDFFQNDDWNYVRLEDTTILNTAFQGQNGRYECFAQAREQQHQCVFYSVSPLKVPPEKRHVVMEFITRANYGMVVGNFELDLSDGEVRYKTSLDVEDVDFTPTMVRNLVYPNLLIMDRYFPGVMRVVYGGLTAEEAIQEIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P2</accession>
    <name>E8N0P2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_04030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04030"/>
    <dbReference type="EnsemblBacteria" id="BAJ62437">
        <property type="protein sequence ID" value="BAJ62437"/>
        <property type="gene ID" value="ANT_04030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04030"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OMA" id="MMIMLLA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="32990" checksum="D160481A023F750A" modified="2011-04-05" version="1">MEAGLKPLGREKFWLWAMLAPTLFGLFFSAFGSLLATLALSFTRWDLLTPPQWAGFANYIALFKDPKNLTSLLNTVRFTAMYVPGVVIVSLLVAVLMNRGLKGISFFRTAYYLPAVTSAVATALVWQMIYGKDTGILNYLLESLGLQPVCWLCTDMALYSVVIVNIWGAIGEGMIIFLAGLTTIPREYYEAAEMDGAKGLQKFFRITLPLITPSIFFQTLISTINAFQAYDYIYMLTRRGQGDSSVPVVVFSIYRNAWHFSNYGGASAQAIELTLIVAALMGLYLWLEKRFVVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N156</accession>
    <name>E8N156_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ordered locus">ANT_27730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561147.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64799">
        <property type="protein sequence ID" value="BAJ64799"/>
        <property type="gene ID" value="ANT_27730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27730"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_0_0"/>
    <dbReference type="OMA" id="ETMALYM"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="92"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="317" mass="34354" checksum="BC5B16C9E38F61D5" modified="2011-04-05" version="1">MEVTLNHLKRPEESAVDVSRRLQKRTRWGELFIQTFLFLCGAVSIFTTLGIVYELGKEALLFFQMPGVTLVEFFTQTEWQPTVGRFGVLPLVSATVVTTVIAMLVAVPFGLGSAIYLSEYASEKARKILKPALEVLAGIPTVVYGYFALTTVTPFLRIFFGEALNIYNMLSAGLTMGIMIIPLVASISEDALHAVPNSLREGAYAMGATRLETALQVVVPAALSGIIAGFILGFSRAIGETMIVAIAAGSGPNFTFNPLQSAETMTGYIARISGGDVAYDTPDYNSIFAIGLLLFGISLILNIISRRVSSRLREVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N185</accession>
    <name>E8N185_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561175.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28020"/>
    <dbReference type="EnsemblBacteria" id="BAJ64828">
        <property type="protein sequence ID" value="BAJ64828"/>
        <property type="gene ID" value="ANT_28020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28020"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1036839_0_0_0"/>
    <dbReference type="OrthoDB" id="1989593at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228589" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="268" mass="28143" checksum="0AD4C3D7EBF9304A" modified="2011-04-05" version="1">MDRNFRLFTIALALCLLIGLMLTGTVSPATAQPLEQVTYQTPTPQPDGRILYIVQPGDNCLRIELLTGVKVQTLRELNNLDSACTLVQGQELLLGVVTPEPTPTLAPDITPTPLLPTPTPMRGTGQVCVILFADLNGDAVREDSEPPILGGAVSVTDRSGNVSLSGLTTDDPENPLCFADVPEGEYNVSLAVPPGYNPTTTTSVPIQLLAGNVSVIDFGAQISVRQPPPGETQSGGRSPLLLVLGALLVLGGIGLAVYVRLFRNVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N191</accession>
    <name>E8N191_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28080"/>
    <dbReference type="EnsemblBacteria" id="BAJ64834">
        <property type="protein sequence ID" value="BAJ64834"/>
        <property type="gene ID" value="ANT_28080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28080"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033160_2_1_0"/>
    <dbReference type="OMA" id="WDRLQIR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="410" mass="45928" checksum="711A895BD27A2D64" modified="2011-04-05" version="1">MSPQRVTRVLVVENNIQAVKTFRKLLSLIENIEVIDFITTAQEALEMVSETKPDVMLVEEHLPDIDGISFTEIIRRDYPATQVIIVSQDKHYDTVLRALRNGASDFLAHDVSIGEFREAILRASELAARERVSYSPYATVENRSELPELGMRADVITVYSPRGGSGTTTIANNLALALRDNESQIALIDACLQYGDVDILFNELGRLSLMDLTPIAYDLDPKVVKECMILHRSSGLYLLAAPKHPVISEALSGEQICRVLEYTRNLYNHMVINTSSYINESTLAALDLADLIVLVGTQEIACIKSLRSFLEVWDSLGMKRDRLMLVINKYRAESPLTTKKISETLNHPVELFIPEDQESALRAANLGNPLMISNPNADISQAIAELADRVKKKLPTLQSEQRFRLFMKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1B8</accession>
    <name>E8N1B8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561206.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28350"/>
    <dbReference type="EnsemblBacteria" id="BAJ64861">
        <property type="protein sequence ID" value="BAJ64861"/>
        <property type="gene ID" value="ANT_28350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28350"/>
    <dbReference type="eggNOG" id="COG2359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168904_1_0_0"/>
    <dbReference type="OMA" id="IGIEIAC"/>
    <dbReference type="OrthoDB" id="1985350at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007347">
        <property type="entry name" value="SpoVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35331">
        <property type="entry name" value="PTHR35331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04232">
        <property type="entry name" value="SpoVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="86" mass="8956" checksum="446907183FAB45CD" modified="2011-04-05" version="1">MDVIKVKANSRTAAVAGAIAGVIREHKHAEVQAIGAGAVNQAIKALVLAKGYLAEDGISIVAVPEFVDVEIDGKVRTAIKLIVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1D8</accession>
    <name>E8N1D8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561226.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64881">
        <property type="protein sequence ID" value="BAJ64881"/>
        <property type="gene ID" value="ANT_28550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28550"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945601_0_0_0"/>
    <dbReference type="OrthoDB" id="1192714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019092">
        <property type="entry name" value="CRISPR-assoc_prot_NE0113/Csx12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09623">
        <property type="entry name" value="Cas_NE0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="208"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="32545" checksum="CD7F33706A0ADDA2" modified="2011-04-05" version="1">MNATLIATLGTEPQGVTWMLDWLLARGFAIDEVLVLHTSARVIEPALEKLQSEFSQTYPTIQYRAEAVQGEEGAILDIASEKETWAFLRAVYRAIRRVKRAGRPVHLSLTGGRKTMAVYAMVAAQLLFDENDRAWHMISEMHWSGTERRMHAAPLDRYQVVAVPVVRWSDAATVRVLLAEVDDPWEALRRQQEFTLQEVMRRRREFWEHHLTPALREVAELLVREGLDNAEIARRLHKSEHTVANQLTRVYRAFDAWRGVHTGKTGASRAAFIAEFASLFSKGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F2</accession>
    <name>E8N1F2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carb-bd_dom_fam9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561240.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64895">
        <property type="protein sequence ID" value="BAJ64895"/>
        <property type="gene ID" value="ANT_28690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28690"/>
    <dbReference type="eggNOG" id="COG3868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881781_0_0_0"/>
    <dbReference type="OrthoDB" id="1997167at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225387" description="Carb-bd_dom_fam9 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="3">
        <location>
            <begin position="122"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="315" mass="33997" checksum="D48F715940886A39" modified="2011-04-05" version="1">MKRLRLLIPVFALLAVMLACNFPSFGRQAQTPTLPPLEQTLAALYQTASAIPPTPTFPPVATATSAPQVSPTPLPPTATVVPPTAVPPTPAPPTPTSPPRRSVVSNATFMSPAPTLDGDWSEWKKVAKEYPATNVVFGKSEWQNEDDLAGSYYVGWDNTYLYLAVKVRDDRYVQTSSGEMLYKGDSIELLLDTDLLGDFSSDRLNGDDFQLGFALGRPEIASGNPETYVWYPSSKSGAPSGVKIAARYEGAIYRAEIAIPWTVFGITPSRGMRLGFALSVSDNDLPGNAVQQSMVSSAPRRALTDPTTWGEVVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G1</accession>
    <name>E8N1G1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AraC_E_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561249.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64904">
        <property type="protein sequence ID" value="BAJ64904"/>
        <property type="gene ID" value="ANT_28780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28780"/>
    <dbReference type="eggNOG" id="COG3449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1694174_0_0_0"/>
    <dbReference type="OMA" id="LNTEDIH"/>
    <dbReference type="OrthoDB" id="1753030at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="155" mass="17821" checksum="A555DD1C643DA26B" modified="2011-04-05" version="1">MSVNEQPFHVTIQNLTPVFIVYVSCQLQQATGNFSEQIRDGFQRIKDWAQQRGYNPSALKVIGIPRTNGAQLVGYECALELPEFISQDIQDIQTKLLPGGRYIILSLEKDSNTIGETIGRFFAEYMPQHQLIVDPQRPTYEIYYEQTMDFCVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G6</accession>
    <name>E8N1G6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64909">
        <property type="protein sequence ID" value="BAJ64909"/>
        <property type="gene ID" value="ANT_28830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28830"/>
    <dbReference type="HOGENOM" id="CLU_2969231_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="58" mass="6871" checksum="A89A138C450D675A" modified="2011-04-05" version="1">MFFSFQKVETALFSILIVFARVETLYIKQFDLSSALGRKYIGYTKYVRAGGREWLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N3</accession>
    <name>E8N1N3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559033.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06040"/>
    <dbReference type="EnsemblBacteria" id="BAJ62638">
        <property type="protein sequence ID" value="BAJ62638"/>
        <property type="gene ID" value="ANT_06040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06040"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_2_0"/>
    <dbReference type="OMA" id="QRMEIIK"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="151" mass="17119" checksum="6FC2777A1EE28375" modified="2011-04-05" version="1">MKDPEQRFQELMQKLRSREYRLTPQRVALIRLLASSEGHPDAAELYRRLLEQFPTTSLATVYKTLNLLKEMGEVLEIEIDGIGGEGSRFDGNDPTPHPHLICVRCHRILDGQVSLTEEILQAVQGQSGYRVISHRLDFYGICPECQAQGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R3</accession>
    <name>E8N1R3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine dehydratase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559063.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06340"/>
    <dbReference type="EnsemblBacteria" id="BAJ62668">
        <property type="protein sequence ID" value="BAJ62668"/>
        <property type="gene ID" value="ANT_06340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06340"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_4_1_0"/>
    <dbReference type="OMA" id="HEVMIPK"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020025">
        <property type="entry name" value="PseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03589">
        <property type="entry name" value="PseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="335" mass="37619" checksum="D10790DD57BBA2EB" modified="2011-04-05" version="1">MNWSEKVVLITGGTGSFGKKFVEIMLNEYHPAKLIIYSRDELKQHEMRQSGFDHPSLRYFLGDVRDKDRLRRAFEGVDIVVHAAALKQVPACEYNPMEAIKTNILGSSNVVDAALDTGVEKVLALSTDKAVNPVNLYGATKLAAEKLIIQSNAYAGGKVTRLACVRYGNVVGSRGSVVPVFLKQRENGKVTVTDERMTRFWLTLEQGVRFVIRSIEQMRGGEVFVPKIPSMSIMDLARAVAPENDIEIIGIRPGEKLHEVLVSEDEARHTVELDDMFVVMPAEAIWFGLDWHDKGNPLPDGFRYASNNNSQWLTIEQIREMIRPIEEAHRKGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R9</accession>
    <name>E8N1R9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559069.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06400"/>
    <dbReference type="EnsemblBacteria" id="BAJ62674">
        <property type="protein sequence ID" value="BAJ62674"/>
        <property type="gene ID" value="ANT_06400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06400"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820663_0_0_0"/>
    <dbReference type="OrthoDB" id="1127583at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="318" mass="36354" checksum="8234DF41649941D4" modified="2011-04-05" version="1">MRVGQNPAKFVKEVARPERITVAVLNYIPFLSGFYAEALDVLKVCLESARTEAGLPFDLLVFDNASCEEVRQYLLDEHQAGRIQYLFLSEKNLGKGGAWNIILSGAPGEIISYADSDVLFSPGWLKRSVEILETYPNVGMVTARPFRTREEYMTATLDWARRTSEVQVEQGQLIPWETFLEFDLSLGQSEEEIRQRYESTRDVRLTYQGVPAFVGASHWQFTAWKSTLQNFLPFNMDRPMGQVKQLDERMNAAGFLRLMTAEPLAMNMSNTLRGVRQTVTAPAPQPGRKKTSPLLEFPPVKKVLLSLYDSIFRWYYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S8</accession>
    <name>E8N1S8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acylneuraminate cytidylyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06490"/>
    <dbReference type="EnsemblBacteria" id="BAJ62683">
        <property type="protein sequence ID" value="BAJ62683"/>
        <property type="gene ID" value="ANT_06490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06490"/>
    <dbReference type="eggNOG" id="COG1083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042930_5_0_0"/>
    <dbReference type="OMA" id="DIYLMTH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="231" mass="26621" checksum="12EDA6A545230AB0" modified="2011-04-05" version="1">MTTALNRVVALVPMRHHSERVPGKNYRPLAGKPLYRHILDTLLAVPEISEVVIDTDSPVILEGLARDYPQVRAIERPVHLRDGGIPMNEILMHDTSLVPADLYLQTHSTNPLLRAETLSRAIQTLRGVYPAYDSLFGVTRLQVRLWDQLTRPINHNPAILLRTQDLPPVYMENSCVYLFTRQTLEQRRNRLGERPYMFEISQEEAWDIDEESTFQMVEFLLLGRQAKNQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T9</accession>
    <name>E8N1T9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559089.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62694">
        <property type="protein sequence ID" value="BAJ62694"/>
        <property type="gene ID" value="ANT_06600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06600"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227858_0_0_0"/>
    <dbReference type="OMA" id="HDITREV"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="1963"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="2094"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="2319" mass="258413" checksum="E48004F189C5FBFC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X4</accession>
    <name>E8N1X4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_28950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28950"/>
    <dbReference type="EnsemblBacteria" id="BAJ64921">
        <property type="protein sequence ID" value="BAJ64921"/>
        <property type="gene ID" value="ANT_28950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28950"/>
    <dbReference type="eggNOG" id="COG0659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_13_1_0"/>
    <dbReference type="OMA" id="VTNKFPI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="443"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="557" mass="59815" checksum="F372CCEBE319A1DF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z8</accession>
    <name>E8N1Z8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561289.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64945">
        <property type="protein sequence ID" value="BAJ64945"/>
        <property type="gene ID" value="ANT_29190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29190"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_2_3_0"/>
    <dbReference type="OMA" id="PFFWEVP"/>
    <dbReference type="OrthoDB" id="1420919at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="150"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="34568" checksum="15650A862A5A2A30" modified="2011-04-05" version="1">MEQREKNLLGIGFVVLGMLIFSLQDVAVKRFSGQYPILEIVLFRSLTALPVTLLFFRAEGRHGLPTTRRPLLEIIRGGFYFLSFTTYMMGVAALPLGDMAAIRNSAPLMITLLSAMFLGEGISLPRWLGLLTGFVGVLLIVQPGTATFNLGSVFALIATLFYALNVILTRKLHRTDSSATMAFYSSLVYLGASFLLAPLSMLVGEMPDAHPSIAFLFASWRIPSPLDLLIMLGLGLVWAAGMYCIARAYSLGQAPVVAPFEYSSLPINILWGMLLWHHLPTAIMLSGATLTLLSGLYLIYRERRESMLKVETKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N207</accession>
    <name>E8N207_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative polysaccharide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_29280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561298.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29280"/>
    <dbReference type="EnsemblBacteria" id="BAJ64954">
        <property type="protein sequence ID" value="BAJ64954"/>
        <property type="gene ID" value="ANT_29280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29280"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_101_1_0"/>
    <dbReference type="OMA" id="DAYFQHK"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="427" mass="47373" checksum="49A5BE74D9332299" modified="2011-04-05" version="1">MNADEVLHLENISKAYRLYNRQIERLKTLFLTPFTGKEYARTFWALRGINLSVQRGEVLGVIGVNGSGKSTLLQIMAGTLAPTTGRLERRGRLTALLELGAGFHPEFTGRENVYLSGVTLGISEQEMRRRFDEIVAFSGIEDFIDQPVKLYSSGMYVRLAFSIATCVDPEILIVDEALAVGDAGFVMKCMNRMRDLHEQGTAIVLVTHDVQTVRTLCDRAMWLSHGEMRMLGSPMEVTSQYIQMLFEAQQQQASPASVPAPSESDPQGWVVLKARPDLVRWGNGRARIEAYRVHSSTGFASTLEYGDTVEISLRVRALADLPQQAYGAGINLRNLKGLDIITATTCDEGLAFPALRAGQAVEVTFRFQNILAPGDYALVMNVEDRQDAVPAYEDYIENAVFLKVVSNKPVLSVVLPHVETRIDELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N245</accession>
    <name>E8N245_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561336.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64992">
        <property type="protein sequence ID" value="BAJ64992"/>
        <property type="gene ID" value="ANT_29660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29660"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_3_0"/>
    <dbReference type="OMA" id="HPYAKML"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="19345" checksum="01E14EA0F593CB1C" modified="2011-04-05" version="1">MGNILEHIYQRRSIRKYKPDPVPRETLLDLLRAAMAAPSAVNKQPWDFIVLTQPERLAALQEMLPYGKYACPAAIVVCGRLDLAHTEPDGSYWVQDCSAATENLLLAAAGLGLGTVWVGVYPIRERVEAVRQVLNIPPYAVPLNVILVGYPDEEKLPQTRFREDRVHWENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N284</accession>
    <name>E8N284_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30050"/>
    <dbReference type="EnsemblBacteria" id="BAJ65031">
        <property type="protein sequence ID" value="BAJ65031"/>
        <property type="gene ID" value="ANT_30050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30050"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089938_0_0_0"/>
    <dbReference type="OMA" id="WHHQQQI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="31611" checksum="9821ED4D0F2049C2" modified="2011-04-05" version="1">MLTPVEPLNLVELLPPLSSELIALLRSVRRPQWLEQTVCTGWAVRDVTAHLLDTALRDLSIKRDRMAPRLPDAPITNAAELAAHVNRLNAEWVVAARRISPNLLVDMLELVEKQMYAFYKSLPPEGAAVLSLPWSGARSIPVWLDVARIYVERWTHQQHIRMALGAPLLVERRWLFPVFDTLVRALPDIYQIVREPQNTTLTLRITGEAGGEWSLVKRASGWRLYSGAADAPQALLEIEQDMAWRLMTRAVSPQTCRACAVIHGDQSLGLQLLMMCATLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A6</accession>
    <name>E8N2A6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561394.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30270"/>
    <dbReference type="EnsemblBacteria" id="BAJ65053">
        <property type="protein sequence ID" value="BAJ65053"/>
        <property type="gene ID" value="ANT_30270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30270"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024115_0_0_0"/>
    <dbReference type="OMA" id="YVRWTER"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="40"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="707" mass="76366" checksum="190B1E66D4F5331F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F3</accession>
    <name>E8N2F3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ethanolamine utilization cobalamin adenosyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eutT</name>
        <name evidence="6" type="ordered locus">ANT_07250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62759">
        <property type="protein sequence ID" value="BAJ62759"/>
        <property type="gene ID" value="ANT_07250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07250"/>
    <dbReference type="eggNOG" id="COG4812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093470_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="112"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="31791" checksum="3CA0301FFFA64295" modified="2011-04-05" version="1">MGWLSATERRFFMPIVTEAQLRDQIRQPKKGMVIRLPADSRLSPSAQDFLKEWNMEVEFEPAIVPAGNPRPPEDSSAKPAWDKPGEFPVVLTGELPRCSTCGMPVKPKPDHMTQLDNQYFTPKTHPRIRFRGKMDSLHALFLLVSAIARRERYPTLSELLSTLAAYCREISSAEYNQRKVAPLELNGKSDDEIRKATHTPKESVGIDHIVPGSHDSELLLWLNWLRTQVREAEITALEAFTAYEASAPQEPELAHAVNRLSNAVYYLELLFVAGKIEDKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H0</accession>
    <name>E8N2H0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_07420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559169.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62776">
        <property type="protein sequence ID" value="BAJ62776"/>
        <property type="gene ID" value="ANT_07420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07420"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_3_0"/>
    <dbReference type="OMA" id="QRAGIWN"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="298" mass="31716" checksum="A256DCD3C33A35C2" modified="2011-04-05" version="1">MRILVGLINGMISGATPILLAALGGAYTFYAGVFNIAMEGMLLTGAFFAVLGSYYTGSWLIGVLLAVLGALFLALIFILFAVVLKTDEFVTGIALNLFAVGATTYMLRKIFSVKGVFSNAGIQPIPSVRIPLLEQIPVLGEILSGQNLMVWVAVLATFLTYFLIFHTHFGLRLRAAGYNPARLDSSGVPSSRMRALSLLASGVLCGLGGAFLSLGYVNLFAENMSAGRGWISLAAIILVNGNPMGIALISLLFGFSDGLGLLLQGYRVSAQFTAMVPYIATLIALYFYAARKKKLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2H2</accession>
    <name>E8N2H2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein ANT_07440</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559171.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07440"/>
    <dbReference type="EnsemblBacteria" id="BAJ62778">
        <property type="protein sequence ID" value="BAJ62778"/>
        <property type="gene ID" value="ANT_07440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07440"/>
    <dbReference type="eggNOG" id="COG1355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_0"/>
    <dbReference type="OMA" id="EQEAQYG"/>
    <dbReference type="OrthoDB" id="1070303at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="30299" checksum="AF9FD12AF3B3BE49" modified="2011-04-05" version="1">MVAVSDVRPSPIAGTWYSGDAQRLRRQVETYLSEAHIPSLNGEVVAVVAPHAGHRYSGRTAGHAFAAVRGQSPEVVAVLSPFHAMHPAELLTTAHQAYATPLGLIPVDHEALLILEQDLAEQHLSLTRVAYDSEHSLEIELPFLQVALQGDFRLLPLMVRSHSPQVLQTLGKLLAQVLKDRRALLVASTDLSHFYPEKIARQLDAEMLRRLEAFDPLAMLEAETTGKGFACGVGAVAATLWAARALGADRVSILHHSTSADETGDYSAVVGYGAAAILRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N3</accession>
    <name>E8N2N3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559231.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08050"/>
    <dbReference type="EnsemblBacteria" id="BAJ62839">
        <property type="protein sequence ID" value="BAJ62839"/>
        <property type="gene ID" value="ANT_08050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08050"/>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_3_1_0"/>
    <dbReference type="OMA" id="GPHMFED"/>
    <dbReference type="OrthoDB" id="1995095at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="2">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="126" mass="14205" checksum="AF8BCECFA7E32D28" modified="2011-04-05" version="1">MKIAFPTQDGEKIYAHLGQARFFKVIEVQDGAVVNTEMREKEVHQHHDDEQEHPPHAHGGHHAHAMFDLLKDCQVLISGGMGTPAFERAREQGLEVILTGERSIEKALQAYLKGVLESDLRRVHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P4</accession>
    <name>E8N2P4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_08160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559242.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08160"/>
    <dbReference type="EnsemblBacteria" id="BAJ62850">
        <property type="protein sequence ID" value="BAJ62850"/>
        <property type="gene ID" value="ANT_08160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08160"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_0_1_0"/>
    <dbReference type="OMA" id="RFLMPPW"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="422" mass="45689" checksum="17F6F40AD73651A4" modified="2011-04-05" version="1">MKRLWLIAWKDLRLAFRDRAALLFLLIAPFALIMGMALISGRLTTPAGSNTGIRDIPVWIINEDGEELGNALVEVLTSTELADLLEPQVVQDVSAARQAVEEDRIAGVVRIPAGFTRSVIPVQSGNTWQPSPLVQIEFYANPARPTSAMILEAILREFLSRVEAGRIQGHTAILQMLQSGLASYDQIEAITRQMRQSVEKDESDTGLTLQVANQEVKEEVEFDIMAYMAPGMALMFLMFTASYGGRSFLAERRQHTLQRLLTTPASVAQIFGGKMLGVYLTGVAQLFILIGASTLIFGLKWGDALGVVVLVLCATFAATGWGLLITAFSRTPGQVSAIGSAVMLVFGILGGSFLNTEQFPPFLQTLARITPNAWGMDGFAILASGGGLTDLSYTLTGLLVMGGVLFAVSVWAFSRNRQLVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S8</accession>
    <name>E8N2S8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative amylopullulanase</fullName>
            <ecNumber evidence="8">3.2.1.1</ecNumber>
            <ecNumber evidence="8">3.2.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_30520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="8"/>
    <dbReference type="EC" id="3.2.1.41" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561419.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30520"/>
    <dbReference type="EnsemblBacteria" id="BAJ65078">
        <property type="protein sequence ID" value="BAJ65078"/>
        <property type="gene ID" value="ANT_30520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30520"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002894_0_0_0"/>
    <dbReference type="OMA" id="WGYDSLP"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051060">
        <property type="term" value="F:pullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM_fam20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228627" evidence="5">
        <location>
            <begin position="31"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="7">
        <location>
            <begin position="1483"/>
            <end position="1596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ65078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1710" mass="185623" checksum="A395C34DF157D6EB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V8</accession>
    <name>E8N2V8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30820"/>
    <dbReference type="EnsemblBacteria" id="BAJ65108">
        <property type="protein sequence ID" value="BAJ65108"/>
        <property type="gene ID" value="ANT_30820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30820"/>
    <dbReference type="HOGENOM" id="CLU_551697_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="494" mass="53626" checksum="3F7785489C6ED4C2" modified="2011-04-05" version="1">MKVSACHHLPLEGFHPQVEELTWQLPGGADAAQVRLDGALANQDDPRRWLGAEMSISPAGGAPCWWGCLHGVEIQRGGMRWRWDLAQVVNRCAVRYRAPTPWSVEGGAGTFQTPWAEDGRSQRRFGVRERVFSIGEASQDEALARRDTLLAEHAAPRLQFLPALSGREDFVLLEGRGWWHTLGWRYALCAQGWLGSARREGTSLPWGHTSSIQRLAQAFTPDGDGWDCGEIWVWLVKTGAPADSVELSLCADSGGLPGAVLSAFTLPAASLSRDPALGWVRLRPSTPVHLNSGSRYWLVLKRTGALDAQNAYLARLDADGTLGTSPGLLAFNGSAWQSAGAGSLLANLFGEEALTAHLARLLGQDGAGQCLRGVFVRAPSSKRVRLYNNGTRTALEEVNALLALDNLDAFVTPQRFVVLERRSAPPVVPHLTLDADGILRQQDGSPWTLSIPPVGRWAGVRVSASRSVPVRLERVAWRGGVLRVEGFTVWAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V9</accession>
    <name>E8N2V9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561450.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30830"/>
    <dbReference type="EnsemblBacteria" id="BAJ65109">
        <property type="protein sequence ID" value="BAJ65109"/>
        <property type="gene ID" value="ANT_30830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30830"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408642_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225251" evidence="1">
        <location>
            <begin position="28"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="672" mass="72248" checksum="E9411076F4AB364E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N319</accession>
    <name>E8N319_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_31430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561510.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31430"/>
    <dbReference type="EnsemblBacteria" id="BAJ65169">
        <property type="protein sequence ID" value="BAJ65169"/>
        <property type="gene ID" value="ANT_31430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31430"/>
    <dbReference type="HOGENOM" id="CLU_2476588_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="87" mass="9649" checksum="CE72C8239FF07D40" modified="2011-04-05" version="1">MRRNTWMSIVLVVLVIVLVSACSRAQRWRDVDQAQVSTATPIAVVQTAQGIASGAENEYVSVAEEIDSLFQELEKELNQTDILSDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N343</accession>
    <name>E8N343_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_31690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561533.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31690"/>
    <dbReference type="REBASE" id="32161">
        <property type="entry name" value="AthUNI1ORF31680P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65193">
        <property type="protein sequence ID" value="BAJ65193"/>
        <property type="gene ID" value="ANT_31690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31690"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024181_1_0_0"/>
    <dbReference type="OMA" id="CSKHANG"/>
    <dbReference type="OrthoDB" id="396287at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="RM_methylase_Eco57I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eco57I" evidence="3">
        <location>
            <begin position="179"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="513" mass="59322" checksum="26CC684B14472907" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N365</accession>
    <name>E8N365_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_08450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559271.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62879">
        <property type="protein sequence ID" value="BAJ62879"/>
        <property type="gene ID" value="ANT_08450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08450"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_7_2_0"/>
    <dbReference type="OMA" id="QVHYKPI"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="393" mass="43780" checksum="C4C9A59CCF85A5F4" modified="2011-04-05" version="1">MSSKQPVVPMSSPDLTDLEREAVLAVLHTPHLSMGERIREFEEAIRRFTGARFAIGVNSGTAGLHLCIRAAGVQPGDLVLTTPFSFVASTNVILYENAIPVFVDVDPQTGNMDVEQTAQALRDLSEGGKATQRWLPRHLPVSPQRLKAILAVDVFGQPADMDELRHLADQYDLHLIEDACEALGAEYKGRKAGMLGDCGVFAFYPNKQITTGEGGMIVTDDEDAAMLMMALRNQGRAPGDTWLQHTYLGYNYRLDEMSAALGTAQMNRIETLLNKREQVARWYMERLAEIPAVEVPYIAPQTTRSSWFVFVIRLARGINREEVAQRLEEKGIPVRPYFLPIHLQPYLVERFGYQPGDYPVTEDLGARGLALPFSSVMTEEQVETVCRALQSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E2</accession>
    <name>E8N3E2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09220"/>
    <dbReference type="EnsemblBacteria" id="BAJ62956">
        <property type="protein sequence ID" value="BAJ62956"/>
        <property type="gene ID" value="ANT_09220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09220"/>
    <dbReference type="HOGENOM" id="CLU_1159221_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="239" mass="25405" checksum="03B8AAA00CCF0420" modified="2011-04-05" version="1">MTTLASSRQQSDRHWWLWFLLFSLIFLLGVAVLALFVFSAEWVQASGLLPASLRSGLAADYSADLRAYSFRALQMGVIEEAIRDRERLGEPAGSSMLPTLAIFLQTPVPTITPTGFAGFNPTATAGTSPTPTLPFQEATPTGLITQTPTATLILSSTPTLVRSATPTQSPTSTLPASSPTRTPANTRPPFPITMTPSATRPTSTPPAPPTPTHTLPPPPPSPTPYQPPIETPPPPTPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G6</accession>
    <name>E8N3G6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09460"/>
    <dbReference type="EnsemblBacteria" id="BAJ62980">
        <property type="protein sequence ID" value="BAJ62980"/>
        <property type="gene ID" value="ANT_09460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09460"/>
    <dbReference type="eggNOG" id="COG4856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640376_0_0_0"/>
    <dbReference type="OMA" id="YQEEPNV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="45743" checksum="3D50C69F10FC112B" modified="2011-04-05" version="1">MVGTKSSPGGTVKLFNQFFKYLPTFLLSLALAIAVWVSAVTANDPIEVRTYPYPITIEYVGLDPAMIANTQESRSLTLRLSAPRSVWEKLTQEQVSVRAFIYLSGLSSGQYTLPVQVQIDKAPVRIVSYSPQTLSIQLDELATETLPIGVVQRGEPAIGYDAGIPSLSVDRATISGPKSVVERVKTLRVVIDLNKAVETITRNLAVQAVDENGLLVSNLTISPAEITVVQPISQRGGYRNVVVKVVTTGQVASGYRLTSLTVSPPAVTVFASNPTLVENLPGYVETNPVDLNGITDDLEVRVALNLPEGITVVGDQTVSVIVGVSAIEGSVTLSDLPIEVINLNPEFSAQLAPKTATIILSGPLPTLDNLKPGEVRVVVDLEGVTPGTYKLVPRVEVLVESLRVESILPNSIEVIVTKGTPTPRPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H5</accession>
    <name>E8N3H5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559380.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09550"/>
    <dbReference type="EnsemblBacteria" id="BAJ62989">
        <property type="protein sequence ID" value="BAJ62989"/>
        <property type="gene ID" value="ANT_09550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09550"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_0"/>
    <dbReference type="OMA" id="FMARVSI"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="44"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="238"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="300" mass="33629" checksum="F9AEADB7D6818802" modified="2011-04-05" version="1">MSAHPPVHEVSNLSKAILDEVSKAIVGKRQVLEKILTTFLAGGHVLLEDYPGLAKTLIANSFAQVLGMTFKRIQFTPDLLPGDITGGYVFNRANNTFVLRQGPVFAHIVLADEINRASPRTQAALLEAMQEYQVTLEGETLKLPEPFLVVATQNPIEYEGTFPLPEAQLDRFLIKLAVGYPSPEEEQEILRRRRDRKQDAIPLQAVTNAEGFLHMREIIEEVYVDPDLERYIVELVHRTRVHRQVAVGASPRGALALLKLGRAYAAMQGRAYVLPDDIKTFARVALQHRIILQPDLWTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J7</accession>
    <name>E8N3J7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">gltX</name>
        <name evidence="13" type="ordered locus">ANT_09770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559402.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63011">
        <property type="protein sequence ID" value="BAJ63011"/>
        <property type="gene ID" value="ANT_09770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09770"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_1_0"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="8"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="347"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="497" mass="56239" checksum="3CEF1E7A60F6A409" modified="2011-04-05" version="1">MTDYSKPVRVRFAPSPTGRMHLGSGRTALYNYLLARKTGGQFILRIEDTDQKRYVPTAEQELIDGMHWLGLQWDEGPDVGGPYGPYRQSERKEIYLHYARQLVESGHAYYCFCTPERLEKVRQEQQARKEQPHYDGTCRHIDPDEAARRVARGERHVIRFKTPREGVTVVRDLLRGEITVENRLIDDYVIVKSDGLALYHLAAMVDDHLMKITHVFRGAEWLPTFPLHALIIRAFGWQEPEFIHLSVFLKPSGKGKMSKREAADLMKDGYSIFVTDFKDLGYLPEAVVNWIALMGWSYDDHTEFFTMPDLIEKFSLEGLNPSPAAINFTKLDHFNGLHIRHLSLPDLAQRVKPFLVSAGYAVDDEKLLHIAPLIQPRLTTLDDVVSMAGFFFKDEVEPDPAALVPKGLTPAEAVQVARRSLAVLEGLPEVSPEVAEPPMRALVEELGLSAGQVFGILRVAVTGQTVSPPLFESMEIIGRETCLKRVRRAIELLEAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K2</accession>
    <name>E8N3K2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559407.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09820"/>
    <dbReference type="EnsemblBacteria" id="BAJ63016">
        <property type="protein sequence ID" value="BAJ63016"/>
        <property type="gene ID" value="ANT_09820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09820"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518431_0_0_0"/>
    <dbReference type="OMA" id="DECWAIR"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="380"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="525" mass="60136" checksum="EFA9A48A8EA23CFA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N6</accession>
    <name>E8N3N6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="9" type="ordered locus">ANT_10160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559441.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10160"/>
    <dbReference type="EnsemblBacteria" id="BAJ63050">
        <property type="protein sequence ID" value="BAJ63050"/>
        <property type="gene ID" value="ANT_10160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10160"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_0"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="85"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="20120" checksum="BD13571D85E0E1E3" modified="2011-04-05" version="1">MNRLKEYYQKEVVPALMKSLGLDNVMQVPKIQKVVVNIGLGEALDNPKALEAASADLMAITGQKPVITKARKSIAAFKLREGRAIGAKVTLRGERMWSFLDRLMNVALPRVRDFRGVSRDAFDGRGNYTLGLREQLIFPEIEYDKIDKIRGMEITIVTTAKSDDHAAALLEMLGMPFRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3R7</accession>
    <name>E8N3R7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase chain M</fullName>
            <ecNumber evidence="6">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoM</name>
        <name evidence="6" type="ordered locus">ANT_10470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559471.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63081">
        <property type="protein sequence ID" value="BAJ63081"/>
        <property type="gene ID" value="ANT_10470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10470"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_0"/>
    <dbReference type="OMA" id="RIACSSV"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="129"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="491" mass="53163" checksum="915DFAA44E5319BF" modified="2011-04-05" version="1">MGFPILSLIIFIPLVAGLIILAMPAERKQAIRVIALIASLLDLALAFWVYFAYDVQLGGYQFIERMEWVKSLGIAYFTGVNGVSVPLVLLGAVVLTAGVMVSWHVEERPREFFAFYMFLGTSVQGVFCSLDLFMLFFFFELAVFPKYLMIAIWGYPKTRDYGSMKLTLYLFLGSVLSLVGVLAMWSAGGHTFDMLQLEQAGFSRAFQIGWFLVVFGGFAILGGIFPFHSWAPDGHVAAPTAVSMMLAGVEMKVGAFAALRVAITLMPEGAQFYAPLILALGTVNVVYGALIAMIQSDFKYVIGFSSVSHMGLVMIGFATLNREGLLGAGLQMFSHGVMTALFFAVVGMVYDRAHTRHIPELGGLVQKMPLAALGFIVAGLVSMGMPAFSGFVAEFPIFMGAWQVMPIVAIIAILGVIVTAGYILLVVRRVFFGSLPENLNVLVGDVSVMDKIVIVGLSAMMILMGILPTWSRMVPLIESGIAQILVLVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S7</accession>
    <name>E8N3S7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polynucleotide phosphorylase</fullName>
            <shortName evidence="6">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">pnp</name>
        <name evidence="9" type="ordered locus">ANT_10570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559481.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10570"/>
    <dbReference type="EnsemblBacteria" id="BAJ63091">
        <property type="protein sequence ID" value="BAJ63091"/>
        <property type="gene ID" value="ANT_10570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10570"/>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_0"/>
    <dbReference type="OMA" id="LHILDVM"/>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="623"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="760" mass="82240" checksum="3B525ECA9CE9ECAF" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3T9</accession>
    <name>E8N3T9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative creatinine amidohydrolase</fullName>
            <ecNumber evidence="5">3.5.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_10690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.10" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63103">
        <property type="protein sequence ID" value="BAJ63103"/>
        <property type="gene ID" value="ANT_10690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10690"/>
    <dbReference type="eggNOG" id="COG1402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_3_1_0"/>
    <dbReference type="OMA" id="FHNWWNA"/>
    <dbReference type="OrthoDB" id="984747at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047789">
        <property type="term" value="F:creatininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="226" mass="25299" checksum="133102C747490557" modified="2011-04-05" version="1">MRIEDLNWMDVEAYLQQDDRLILVLGTIEQHGYLSLATDVRIPLALADAASQKTGVLVAPPVNYGVSPYFLTYPGTFSLRLSTFLDTVEDLVRSAYAQGFRRILVLNGHGGNDAARGRLVELMNQLPGLKIAWYAWWTSHSVEAFAIEHQLERNHANWMEAFPFTRVSDLPEGEKVSPSVKGLLNAEETRTVYGDGSFGGPYQVPDALMDELFAVCLQDVLYLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3U0</accession>
    <name>E8N3U0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_10700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559494.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63104">
        <property type="protein sequence ID" value="BAJ63104"/>
        <property type="gene ID" value="ANT_10700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10700"/>
    <dbReference type="HOGENOM" id="CLU_1500554_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225455" evidence="3">
        <location>
            <begin position="24"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="204" mass="22889" checksum="5E4AE6D47397EFB4" modified="2011-04-05" version="1">MKHKMMKWLSVLVVLVMALGSIAAAPSPVDASGIPAQEVPPSDEAGMVQRPPRPEVLEQAYQRLQKTLEAQKERLQRAEQQIPNWESKIAELKQKGLDTSALEKALANFKDSLMKARQSHEEAARILAQHPGFDENGKVVDPKQAAQTVRDAGKAIRVTHRIMENAMWEMLRAFREFRRDNRPNPGEPRPPKPPVEDTTAPVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W0</accession>
    <name>E8N3W0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63124">
        <property type="protein sequence ID" value="BAJ63124"/>
        <property type="gene ID" value="ANT_10900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10900"/>
    <dbReference type="eggNOG" id="COG2949">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051474_0_0_0"/>
    <dbReference type="OMA" id="IDAWGVA"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="50"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="24958" checksum="00DCE1EC6BA9DAC0" modified="2011-04-05" version="1">MYRRTFSRIVSMFIVLILVATTLLLAARGFTALYAKSRIIPVADAPEMPVAIVFGAGLSRDGTPSPVLRDRVETAAALYFQGKVKKLLMSGDNRFVDYNEPGAMRQYALDLGVPAENIVLDYAGRRTYDTCYRARAIFGVTEAILVTQPFHLPRALYLCNQLGVKAWGVPADNRYYLKRSQLIWNIRETMATLVALWEVWVTHPVPVLGPYEPIFPEEQRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N484</accession>
    <name>E8N484_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">citB</name>
        <name evidence="11" type="ordered locus">ANT_12140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559636.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63248">
        <property type="protein sequence ID" value="BAJ63248"/>
        <property type="gene ID" value="ANT_12140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12140"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013476_2_1_0"/>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="OrthoDB" id="363064at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="9">
        <location>
            <begin position="80"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="10">
        <location>
            <begin position="697"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="897" mass="97915" checksum="B92C8373E119CC62" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N486</accession>
    <name>E8N486_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_12160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12160"/>
    <dbReference type="EnsemblBacteria" id="BAJ63250">
        <property type="protein sequence ID" value="BAJ63250"/>
        <property type="gene ID" value="ANT_12160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12160"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_1_0"/>
    <dbReference type="OMA" id="IGLHYST"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="63"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="291" mass="31664" checksum="787031A45CBB6153" modified="2011-04-05" version="1">MASGESSIPRSPVLSLPKESLQSRLEHFPWWFVAMVSIALATLGVIFSQPSYNQAFVFIQAGIHVTITTTLTAFVISLVIGLMAGLGRIARNVFFRNLSTLYVEIVRGIPMLVLIFFIAFVAVPAVTSALNALGRVLVEAGLTWAGGLTQLENSGVPMQIRAIIALSVTYGAFSAEVFRAGIQSIPKGQMEAARSQGMTYWQAMRYVILPQAIRNVLPALGNDFVSMLKDSSLVSVLAVRDITQVARLYAGQTFRYPEAFTTLAVLYLIMTLVLSLGVKAIERGLSHGQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N498</accession>
    <name>E8N498_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_12280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12280"/>
    <dbReference type="EnsemblBacteria" id="BAJ63262">
        <property type="protein sequence ID" value="BAJ63262"/>
        <property type="gene ID" value="ANT_12280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12280"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010123_0_0_0"/>
    <dbReference type="OMA" id="MAAVWEL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="10">
        <location>
            <begin position="339"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="565"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1068" mass="122808" checksum="06BDA2570B585093" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N499</accession>
    <name>E8N499_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63263">
        <property type="protein sequence ID" value="BAJ63263"/>
        <property type="gene ID" value="ANT_12290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12290"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_757892_0_0_0"/>
    <dbReference type="OMA" id="WTHHRTE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="176"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="365" mass="42329" checksum="C33470E378D65402" modified="2011-04-05" version="1">MKNILQLPQVKRKKPVRPKRCPYCQGETFQRWGVEKRRIEDVKVRHVEVVRYRCTRCRRTFRDYPEGVGNGQHSERLKKLSVILWSLGLSYRRVAGVLRIFGLRLSHMSGWRHVQAEGEKLMGELKWKSVRVVGVDGAWVGGKGVMVAVDLGDGSLLEVAEVDEKDSRALFTWLKRLKERHDIGAIVSDDLAIYKQLTDELEIGHQVCQFHVRRWVKPALKGLQAELDPAWQGVLEKVEEILRDLPWHGDRLLHRLWKSLPGRSTPPEGKRTPLEKLRDLILRLSRDWQRYVAFYADAGIPWTHHRTEQRIGRLRIQNHRRVAPRKHGCLSVLGMSPPVIPSSPPVFSLPSFFRKFAHQFVTVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B1</accession>
    <name>E8N4B1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine biosynthesis protein LysX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysX</name>
        <name evidence="6" type="ordered locus">ANT_12410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559663.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63275">
        <property type="protein sequence ID" value="BAJ63275"/>
        <property type="gene ID" value="ANT_12410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12410"/>
    <dbReference type="eggNOG" id="COG0189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_2_1_0"/>
    <dbReference type="OMA" id="YEHKVFY"/>
    <dbReference type="OrthoDB" id="937913at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="93"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="316" mass="35057" checksum="2491118015FE9BD9" modified="2011-04-05" version="1">MKIGIILSRVRVEEKWLLEAFEKRGIDFERIDDRESVFDISRPDSWMVFDVVLERSISFARGLYATQILNSWGIPTVNMAHVAATCGDKLATSSALAKAGVPQPRIKVAFTPEAALQAIEELGYPVVLKPVIGSWGRLLAKINDRDAAEAILEHKETLGSYQHSIYYIQEYIQKPERDIRAFVVGDQTVCAIYRNSSHWITNTARNGQGENCPITPELNDLCVKAAHAVGGGVLAVDVLEDPQRGYLVNEINHTMEFHTLAPTTGIDIAGIIADYTIAVARKDIRLHSPIIQPPQNGQALWNALSHTLAEWSHLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D4</accession>
    <name>E8N4D4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559686.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12640"/>
    <dbReference type="EnsemblBacteria" id="BAJ63298">
        <property type="protein sequence ID" value="BAJ63298"/>
        <property type="gene ID" value="ANT_12640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12640"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_0"/>
    <dbReference type="OMA" id="NIREVRW"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="183" mass="21845" checksum="9ACF8B91ED46630F" modified="2011-04-05" version="1">MLFSQRLRLRPIQRSDLPFFVEWLNDPEVRQFITVTVPLSLEEEEQWYEQMLKQPKPERPFAIEVREEGEWRLIGNITLFDLSWVNRSAEVGILIGDKRFWNRGYGREAMRLMVQHAFETLNLNRVYLRVDVENIRGIKSYEQAGFVKEGILRQANYRNGKYSDMMVMSVLRSEWQTPTREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4H3</accession>
    <name>E8N4H3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glnA</name>
        <name evidence="6" type="ordered locus">ANT_13030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63337">
        <property type="protein sequence ID" value="BAJ63337"/>
        <property type="gene ID" value="ANT_13030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13030"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_0"/>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="5">
        <location>
            <begin position="108"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="477" mass="53566" checksum="589591ECB2A05D01" modified="2011-04-05" version="1">MTLMEVLMTTVADVMKLKEKVQMVDLRFTDMPGTWQHFSIPAVQMEESLFEEGIGFDGSSIRGFKEIHESDMLLIPDPSTAFIDPVLEVPTLVIICDVYDPITRQPYTRDPRHIAKKAEAYLKQTGIATTSYWGPEAEFFLFNDVRYGGGTNSSFYHIDSVEGWWKSGEDLKPNLGAQIPPKRGYFPVPPADTQQDIRSKIVLALMSAGITVEVHHHEVATAGQAEIDMRFDTLLRMADNVMVYKYIVKNVARQNGLTATFMPKPLFGDNGSGMHVHQSLWNGSTNIFYDPSGYASLSDLAKYYIGGLLKHAPALLAIVAPTTNSYRRLVPGFEAPVNLAYSQRNRSAICRIPVYSKSPKAKRIEFRAPDPSANPYLTFAALLMAGLDGIQNRIDPGEPADKDLYELPPEEAKLIKQVPGSLDAVLKALEEDHEFLLRGDVFTTDFLEAYIAYKYENEVDPVRMRPHPYEFTLYYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4H9</accession>
    <name>E8N4H9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ordered locus">ANT_13110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559730.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63343">
        <property type="protein sequence ID" value="BAJ63343"/>
        <property type="gene ID" value="ANT_13110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13110"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_0"/>
    <dbReference type="OMA" id="WEILCGF"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="243"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="40758" checksum="FC8BDF6496F05D7D" modified="2011-04-05" version="1">MDHADLTTWLEIDLSVIRKNIRLLQEIAGVPVMAVVKANAYGHGLIEASRAAVQAGVQWLGVARIDEALELHRAGIRAHPIVLGYTPPERAGEAAQAGVRLAVYDSQVAQAYAAQAKAVGKPLYVHAKFDTGMGRLGASPEEGVEWMRWLHTLEGLQVEGAFTHLAEADDPQKPTTHWQLDRFDKLLSGLESAGLRPAWVHAANSAGALYFPRARYNLVRTGIAIYGLNPSAHAPLPEGFRPALTWKTRLTSVKIFPPNHGISYNYRYRTKSEERIGVCAVGYADGFRRQMGNMVLVRGRRVPVVGSVCMDQCMVNLDQVPEAQMGDEVVLIGQQGNDEITAEERAHEWGTIHYEVVCGLANRLPRIYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N8</accession>
    <name>E8N4N8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">ruvC</name>
        <name evidence="15" type="ordered locus">ANT_13740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559786.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13740"/>
    <dbReference type="EnsemblBacteria" id="BAJ63402">
        <property type="protein sequence ID" value="BAJ63402"/>
        <property type="gene ID" value="ANT_13740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13740"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_3_1_0"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ63402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="167" mass="18369" checksum="535233C3F113FF5A" modified="2011-04-05" version="1">MLVLGIDPGTATTGYGLVRESQDGSLHLVGYGVIQTPAGLEEEKRLLLLYHKLNELILLHAPNAGVVEKLFFRRNVTTAIGVGQARGVVLLALAQHGIPVWEYTPMEVKQSVSGYGNADKRQVQLMVQTLLNLEEYPKPDDAADALAVAICHLHHYRWKSFEKGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W5</accession>
    <name>E8N4W5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase molybdoprotein family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559861.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63479">
        <property type="protein sequence ID" value="BAJ63479"/>
        <property type="gene ID" value="ANT_14510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14510"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_3_0"/>
    <dbReference type="OMA" id="MFTFGYR"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="744" mass="81095" checksum="F4B8B3F7EB2DC94C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N549</accession>
    <name>E8N549_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_15350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559945.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63563">
        <property type="protein sequence ID" value="BAJ63563"/>
        <property type="gene ID" value="ANT_15350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15350"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="YGQDDAH"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="228" mass="26406" checksum="41F715A46744C7C4" modified="2011-04-05" version="1">MQEKDSGPLTILLVEDDPAIIQLVALGLRMEKFEVITAIDGREGFQLFLEKKPDLLIVDWMLPKMDGITLCRKIRELSDLPIIIITAKDAVQDRVEGLDTGADDYLVKPFHLDELLARVRARLRRRLPISHQLIFSDLSFDLETHEFFRGKRLLHFTATEQKVLELFLRHPRQVLSKETILEKVWGYDFGGDANIVEQYIRSIRQKLGEPNLIQTIRGLGYSLREEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N556</accession>
    <name>E8N556_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminopimelate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysA</name>
        <name evidence="6" type="ordered locus">ANT_15420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559952.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15420"/>
    <dbReference type="EnsemblBacteria" id="BAJ63570">
        <property type="protein sequence ID" value="BAJ63570"/>
        <property type="gene ID" value="ANT_15420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15420"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_0"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="39"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="56"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="431" mass="48720" checksum="9F4C7A7C9D5D24E1" modified="2011-04-05" version="1">MSSILPLFPDNMVVSERGRINLSGFDILELAEKYSTPLYIYDAHTIFHNIDTLKDTLKKYYPGESIITYAAKAYFSLRFAQFIAKTEVGIDAVSENELIFALRAGIKPERIHLHGNNKTYAELDHAVQANIHAIVIDNFEDIEILERLSHKKSPISVWIRVNPEIDEIATHPYRNTGHSVSKFGLTIRDGQAETAIRMLMANPNFRLIGIHTHIGSQIFDTAPYKQAIGEMLKLARRCNWIPAEVCPGGGWGVPYRHDEMINNNIENWIREISIVIQEEYRGSNFLPRLILEPGRWIVARAGIAIYTVGRVKQFSNGEKLLAVDGGMGDNIRPPLYQAEYEAIVAENPLGSPTTCYRIVGRFCESGDELIHEIDLPEVQTGNHLIFPVSGAYHLSMASNYNLFARPAVLWVENGSVNVLQERENLFTGWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N569</accession>
    <name>E8N569_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_15550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63583">
        <property type="protein sequence ID" value="BAJ63583"/>
        <property type="gene ID" value="ANT_15550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15550"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_0_0"/>
    <dbReference type="OMA" id="IVIWRQG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034530">
        <property type="entry name" value="HpnP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00303">
        <property type="entry name" value="hopanoid_C2-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="162"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="502" mass="57741" checksum="4C6061CC09109DC7" modified="2011-04-05" version="1">MGEMNALLIYPEFPETFWSFKHALKFIQKKASSPPLGLVTIASLLPEDWNIRIVDLNVSPLTHDDIVWADLAMISAMVVQKKSAHEVIQRCKDAGKKVVAGGPLFLGEWEQFPQVDHFVLNEGEITLPQFLKDFLSGNANRIYQTTSFANMQTSPVPRWELIDLKAYDSLSIQYSRGCPFNCDFCNVTAMLGHRPRTKNVEQILAELDKMYQLGWRRNIFFVDDNFIGNRKQLKEEILPALIEWRKDKKGCHFITEASINLADDPELMELMRTAGFVSVFVGIETPVEDSLSECNKKQNLKRDLLTAVQTLQKNGLQVMGGFIVGFDHDPPNIFQKQIEFIQKSGIVTAMVGLLQAPYGTKLYERMEKEGRIVKELSGDNTNGTTNIIPKMGFNALQAGYHVLLEELYKPEGFYSRVKTFLENYTLPEVRPVQVHTEEIMAFFRSIWELGIKGKERKEFWKLFFWTLLKHPQKFPLAITFSIYGYHFRQIFEKNIKQQESMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A6</accession>
    <name>E8N5A6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mevalonate kinase</fullName>
            <ecNumber evidence="7">2.7.1.36</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mvk</name>
        <name evidence="7" type="ordered locus">ANT_15940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560000.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15940"/>
    <dbReference type="EnsemblBacteria" id="BAJ63620">
        <property type="protein sequence ID" value="BAJ63620"/>
        <property type="gene ID" value="ANT_15940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15940"/>
    <dbReference type="eggNOG" id="COG1577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_0"/>
    <dbReference type="OMA" id="HSAVYGF"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="93"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="224"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="313" mass="33777" checksum="E6CE692FCBDACAA5" modified="2011-04-05" version="1">MTGIFATAPGKIILFGEHAVVYGYPAIAVPVNQVRAKVLILPIPANKPDEVYIEAPDIHLNSHLNQLAFKDPLRIVIEEVQNILRLSYLPPMRIRITSTIPVAAGLGSGAAVSVALARALANYLGHPLPDETICQIAFRAEHSYHGTPSGIDNTVITYNQPLFFQKGKPYELLGVEKPFFIVIGNTGIASPTGEVVAEVRKNREQNPEKYNALFEKIGQIVLYARKLIEHGNVVDLGSMLTENHCLLKEMGVSCKELDILVETAIHAGAYGAKLSGGGKGGNMIALASSEKLPQITQALRDAGATTVITTEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D5</accession>
    <name>E8N5D5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_16230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16230"/>
    <dbReference type="EnsemblBacteria" id="BAJ63649">
        <property type="protein sequence ID" value="BAJ63649"/>
        <property type="gene ID" value="ANT_16230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16230"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_1_0_0"/>
    <dbReference type="OMA" id="HFHIPLQ"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="128"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="429" mass="48238" checksum="60ACEECC0DC79F7B" modified="2011-04-05" version="1">MRIFLDSVGCRLNQSEIEKFALEFRAAGHTIVASPSEADLVVVNTCAVTAEAASDSRQKIRQAARYTSGKIAVTGCWATLDRVGAMSLPKVDRVFLNDQKDTLVSTVLGIPTEVFDIEPLAREPLPGLHARTRAFIKVQDGCDNHCTFCVTRLARGKGRSRNIAEVLSDIRIAQAGGAKEVVLTGVHLGSWGQDFTPKMHLRDLIKVILQESDIPRLRLSSLEPWNLDEGFFALWEDSRLCRHLHLPLQSGCATTLRRMARKTSPQQFETLVNQARRWISDVAITTDIIVGFPGETEEEFEESLRFVERMRFAGGHVFTYSDRPGTAATRLPNPVPPEIRKLRNARIREVVQESAQNYLKQFLGKEVLVLWESTDSLGPLGWNLHGLTDHYIKVVSLSREKLWNRFSRVKLVEVEGDRIRGEILETLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5M0</accession>
    <name>E8N5M0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17080"/>
    <dbReference type="EnsemblBacteria" id="BAJ63734">
        <property type="protein sequence ID" value="BAJ63734"/>
        <property type="gene ID" value="ANT_17080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17080"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512782_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="29"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="556" mass="63221" checksum="6C8330B61C8DC756" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5M6</accession>
    <name>E8N5M6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_17140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560119.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63740">
        <property type="protein sequence ID" value="BAJ63740"/>
        <property type="gene ID" value="ANT_17140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17140"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507767_0_0_0"/>
    <dbReference type="OMA" id="EISAFRM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="332"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="536" mass="61111" checksum="3B77FFCE6060EAA9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Q3</accession>
    <name>E8N5Q3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560145.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63767">
        <property type="protein sequence ID" value="BAJ63767"/>
        <property type="gene ID" value="ANT_17410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17410"/>
    <dbReference type="HOGENOM" id="CLU_1286550_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="214" mass="24666" checksum="E12A0AF9CCA9A34D" modified="2011-04-05" version="1">MNKQTWSIFFIFAFALSLWFGFLVAIRMEQLGLIHFSASTSTEPQSQVNYLLIEVDSLTSRTPVFQSAWIALRYQSSTQSALHLIRIDTSEEFHTNLQNAFQVRQNKLGSKFTKHLTKKGYEWGYFIVVDQESLKTLKLAFPKEISDSTENNLKGLLSATCQVLGARPILSYPVNFDTLKEHIVTNWTKDLANKEWERLTASPKTTRCEWYPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U7</accession>
    <name>E8N5U7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase nickel incorporation protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypB</name>
        <name evidence="3" type="ordered locus">ANT_17850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560189.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63811">
        <property type="protein sequence ID" value="BAJ63811"/>
        <property type="gene ID" value="ANT_17850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17850"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056148_0_0_0"/>
    <dbReference type="OMA" id="ECHLDAH"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="34"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="221" mass="24036" checksum="4D854235079E0396" modified="2011-04-05" version="1">MSNRVTIVENILSANDQVAQLNRTLLDEKKIFSINLMASPGAGKTSFILQTIKALSASYRIGVLEGDTAPVTIDADRVNAAGMPAVQINTGGDCHLDAVMVNKGLGELPLDQLDVVIIENVGNLICPAAFKLGTHVNVLIASIPEGDDKPYKYPAIYRGIQVLIINKTDLLPYVTFNMDYFRQGVEMLNPGLITFPVSCKTGEGIEEWVKWLAAQVKMMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W6</accession>
    <name>E8N5W6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="4">2.3.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560208.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63830">
        <property type="protein sequence ID" value="BAJ63830"/>
        <property type="gene ID" value="ANT_18040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18040"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_3_0"/>
    <dbReference type="OMA" id="YPYFRPI"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="47"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="392" mass="43138" checksum="848BCC3896801975" modified="2011-04-05" version="1">MDIFEKTHQFTAAKEAIKEGYYPYFIPLNENEGTEVVYKGHRLIMCGSNNYLGLTTHPKVREAAMEAIRRYGTSCTGSRFLNGTLEMHEELERRLAKWVKKEAALVFSTGMQANLGAVSAIVGRGDYVILDKDDHASIVDGARLSFGEIARFRHNDVTHLEKVLQSLPESAGKLVVVDGVFSMGGDLALLKEMVPVCQKYGARLMVDDAHGMGVMGGGRGTAEELGVTAQVDLIMSTFSKSFASLGGFIAGDEDVVHYIKHHARSLIFSASIPPANAAAALAALEIMEQEPERVQRVIHIGKKMKKSFEEMGYNTGNSQTPIIPIIIGDDQKTFFFWKALFEAGVFVNPVISPAVPPGMQLLRTSYMATHTDEQLDQVLEIFYQIGKQMAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z3</accession>
    <name>E8N5Z3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 14" type="primary">lon</name>
        <name evidence="14" type="ordered locus">ANT_18310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560234.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63857">
        <property type="protein sequence ID" value="BAJ63857"/>
        <property type="gene ID" value="ANT_18310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18310"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_0"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="12">
        <location>
            <begin position="630"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="815"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="717"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="760"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="392"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ63857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="839" mass="93673" checksum="22A12D8EB89733DE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N634</accession>
    <name>E8N634_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-D-xylosidase</fullName>
            <ecNumber evidence="4">3.2.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.37" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560275.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63898">
        <property type="protein sequence ID" value="BAJ63898"/>
        <property type="gene ID" value="ANT_18720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18720"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_0"/>
    <dbReference type="OMA" id="QCARDSN"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="621"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="712" mass="78612" checksum="3769AA18A29EF136" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N655</accession>
    <name>E8N655_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4173 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18930"/>
    <dbReference type="EnsemblBacteria" id="BAJ63919">
        <property type="protein sequence ID" value="BAJ63919"/>
        <property type="gene ID" value="ANT_18930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18930"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025121_1_1_0"/>
    <dbReference type="OMA" id="YALTYWR"/>
    <dbReference type="OrthoDB" id="1213947at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="2">
        <location>
            <begin position="248"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="521" mass="59018" checksum="2F0FB53B329F8879" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N657</accession>
    <name>E8N657_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rplL</name>
        <name evidence="7" type="ordered locus">ANT_18950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560298.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18950"/>
    <dbReference type="EnsemblBacteria" id="BAJ63921">
        <property type="protein sequence ID" value="BAJ63921"/>
        <property type="gene ID" value="ANT_18950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18950"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_0_0"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="129" mass="13133" checksum="28ADCAF40BD2A40C" modified="2011-04-05" version="1">MADLNKLVEELSALSVLEAAELVKMLEEKWGVSAAAPVAAVAAMPVAGGAAAPAEPVEEKTEFDVVLKDAGPKKIEVIKVIRQLTNLGLVEAKTMAETAGAKVLSGVGKEAANDAKSKLEAAGAVVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N658</accession>
    <name>E8N658_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rplJ</name>
        <name evidence="6" type="ordered locus">ANT_18960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560299.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63922">
        <property type="protein sequence ID" value="BAJ63922"/>
        <property type="gene ID" value="ANT_18960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18960"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_1_2_0"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="175" mass="18903" checksum="2E552B33561A6D3B" modified="2011-04-05" version="1">MAFTREQKSAIMQQYQEWVAKSQAMFLLEYTKMNQKDMDTLRAKVREAGGEIHVVKNTLFGKVLSEAGVDYGKMLEKTTMVGFAFNDPPALAKVVNEAAKSEVFAVKGGFLGKVSINAVQVKALADMPPLPVLRAQLLGVLLAPASKLVRTIAEPGRSIAGVIKAYSEKGQTASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N690</accession>
    <name>E8N690_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tpiA</name>
        <name evidence="5" type="ordered locus">ANT_19280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560327.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19280"/>
    <dbReference type="EnsemblBacteria" id="BAJ63954">
        <property type="protein sequence ID" value="BAJ63954"/>
        <property type="gene ID" value="ANT_19280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19280"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_0"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="255" mass="27478" checksum="23B1832A15B9BFE6" modified="2011-04-05" version="1">MRKKFVAGNWKMNKTAEEARLLLNELIPALEPFSHVERAVCPPFPYLMMVRHMLEGTNIGMGAQNMHWEASGAFTGEVSPKMVAEFCQYVILGHSERRTYFGETDETVNRKVKSALSTGLTPIVCVGETLAENEAGKTAEVVWRQITEGLKDLLPEEGLKLVIAYEPVWAIGTGRAATAEVAQSVHANVVRPALAHLFGQEVAGQIRIQYGGSVTAKNAPELFAMPDIDGALVGGASLKAGEFAAIVQAAAEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI5</accession>
    <name>E8MXI5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_20400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560436.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20400"/>
    <dbReference type="EnsemblBacteria" id="BAJ64066">
        <property type="protein sequence ID" value="BAJ64066"/>
        <property type="gene ID" value="ANT_20400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20400"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="HIEKMQT"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="168"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="228"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="443" mass="48485" checksum="929E4AF85DE3C1DE" modified="2011-04-05" version="1">MRVKLLLSYGLVALITALSVILIFQYTSIGELRSFMLRGGMVGVNDLAGALETYYQQNGGWEGVEALLPTGRGMGRMMSSRMRVADTSGRVIADTQGVVGERISLLERTRAVILRDTQNRIIGYLLVEGGVMGGQNSAQLFSRLTQASIWAGIVGGIAALILALFLSNSFLSPLKSLIQASQKMAEGDLSVRVPVKGKDELAVLARTFNHMANSLERAEKNRKAMTADIAHELRTPIAVQRAHLEALQDGIYPLTPENLQPVLDQTEFLARLVEDLRVLALADAGQIPLEFREIAPLDLVRRIYERFRPEADAKSISLQIVDETSGMRLSIQGDERRIEQILNNLMSNALRFTPEGGRITLRVSQQGNMLAFMVEDTGPGISPEDLPFIFERFYRGNRNQSSEGTGLGLAIARQLALAHGGTLEAANRPEGGAKFTLSLPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL4</accession>
    <name>E8MXL4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="4" type="ordered locus">ANT_20690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560465.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64095">
        <property type="protein sequence ID" value="BAJ64095"/>
        <property type="gene ID" value="ANT_20690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20690"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_3_0"/>
    <dbReference type="OMA" id="VFRNMET"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="127"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="189" mass="21801" checksum="8F594E28EBC4EFF8" modified="2011-04-05" version="1">MTLKVEIYPKNLELTTHIADYITKKASKLDRYLSDIEETRVDLEYQKSMRNPADRQVAQITIRGRGYILRTQERSDDILTAFDTALDNLQRKMERFKGKRVRGRGDGTPASGVKETEAGAMTIEEETPPLITRRKTFTLVPMDEMEALEQMKALGHENFFVFYNINTNSVNVLYQRRDGTYGLIETRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN5</accession>
    <name>E8MXN5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty-acid-CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fadD</name>
        <name evidence="3" type="ordered locus">ANT_20900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560486.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64116">
        <property type="protein sequence ID" value="BAJ64116"/>
        <property type="gene ID" value="ANT_20900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20900"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_0"/>
    <dbReference type="OMA" id="WLMQRAF"/>
    <dbReference type="OrthoDB" id="961884at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="463"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="552" mass="61461" checksum="F4A22CE03F4B2F84" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP0</accession>
    <name>E8MXP0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20950"/>
    <dbReference type="EnsemblBacteria" id="BAJ64121">
        <property type="protein sequence ID" value="BAJ64121"/>
        <property type="gene ID" value="ANT_20950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20950"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_5_0_0"/>
    <dbReference type="OMA" id="HDHVILT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="147" mass="16648" checksum="EDE00EA83F375DC3" modified="2011-04-05" version="1">MEHSASDLPSQWLQALQNDGCRITHARRAIVNLLIQSDRALGPIEIYDLARKEYSALGLVTVYRTLEKLEELGLIQRVHMPDGCHRYLKSAQGHEHLLLCTKCGKTVTFRGDDLNQLNLNVSQKTGFVIHDHWLQLFGLCPKCQGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP1</accession>
    <name>E8MXP1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_20960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560492.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20960"/>
    <dbReference type="EnsemblBacteria" id="BAJ64122">
        <property type="protein sequence ID" value="BAJ64122"/>
        <property type="gene ID" value="ANT_20960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20960"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_1_0"/>
    <dbReference type="OMA" id="FHEAFDY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225299" evidence="5">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="321" mass="34915" checksum="2FD3D6007736B231" modified="2011-04-05" version="1">MYTKNFLKILFVLVLGSVLMGCQTVSTSPAENGRLSVAATTSIVADVVQQIGGDSINVHQVIPNGTDPHSFSPTPRDLSQISGVKVVFVNGAGLEETLLKVLKNTVPDATLIEVSQNNPLIEGHEHPHGDEAGMGETHTTEGEEGHPLDPHTWTDPNNVMQWVDIIVTELSRLDPAHQQMYQKNGEAYKNQLKEADGWIQEQVAQIPAENRKLVTDHLAWGYFAKRYGFEQIGAIIPGFSTLAEPSAQEIAALEEQIRSQNIRAIFVGNQSNPALAKRIAEDTGAKVVPLYVGTLSDSDGPAATYLAYLRYNVNAIVDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS0</accession>
    <name>E8MXS0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560521.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21250"/>
    <dbReference type="EnsemblBacteria" id="BAJ64151">
        <property type="protein sequence ID" value="BAJ64151"/>
        <property type="gene ID" value="ANT_21250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21250"/>
    <dbReference type="eggNOG" id="COG4279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2285557_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="101" mass="11807" checksum="5B1BFBA56E3146EB" modified="2011-04-05" version="1">MTEDTQKRLQKAFSGLSARQMRVLDIVDGRIWAVHSTMSSRQGAIYLVTYGIDQWTWDRHLHHLPDPKECPEWQCSCPDFEKRHQPCKHILAVKIMHAIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV1</accession>
    <name>E8MXV1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_21560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560552.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64182">
        <property type="protein sequence ID" value="BAJ64182"/>
        <property type="gene ID" value="ANT_21560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21560"/>
    <dbReference type="eggNOG" id="COG5354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411994_0_0_0"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225303" evidence="3">
        <location>
            <begin position="23"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="646"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="687" mass="76268" checksum="F188FC5933507AB6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ4</accession>
    <name>E8MXZ4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_21990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560594.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21990"/>
    <dbReference type="EnsemblBacteria" id="BAJ64225">
        <property type="protein sequence ID" value="BAJ64225"/>
        <property type="gene ID" value="ANT_21990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21990"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_0_0"/>
    <dbReference type="OMA" id="IVNFHCR"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="225"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="33194" checksum="73F21C5121463F00" modified="2011-04-05" version="1">MSELSVAQQQEKKHAALTSVIAAVGLTSFKIVVGALTGSLGILAEAAHSALDLVAALVTFLAVRISGKPADEEHHYGHGKVESLSALFETLLLLATCVWIIYEAIQRLFFKVVEIEVSVWAFVVMVVSIIVDVNRSRMLYAAARKHNSQALEADALHFSTDIWSSSVVILGLTGVWISERVPQLKFLQHADAVAALGVAVIVIFISMELGIRTVKGLMDTAPQGAVESIKKAVEEIPGVINCHQIRVRSSGAEVFVDCHVVVSSEWSLQQTHDLADQIEAVIQQQLPGADVTVHPEPGAANPSTTKEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY36</accession>
    <name>E8MY36_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsF</name>
        <name evidence="6" type="ordered locus">ANT_22410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560635.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22410"/>
    <dbReference type="EnsemblBacteria" id="BAJ64267">
        <property type="protein sequence ID" value="BAJ64267"/>
        <property type="gene ID" value="ANT_22410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22410"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_5_1_0"/>
    <dbReference type="OMA" id="ITEASPM"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="94" mass="10663" checksum="ED2167C8C7F90218" modified="2011-04-05" version="1">MRNYEVIFIIHPELDETASTALIEKVQGWITGAGGTVEKTDVWGKRTMAYSIRKQREGNYVYMQVAMPPAFVNELSTNLRLTEPVLRYLITAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB1</accession>
    <name>E8MYB1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558454.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00220"/>
    <dbReference type="EnsemblBacteria" id="BAJ62056">
        <property type="protein sequence ID" value="BAJ62056"/>
        <property type="gene ID" value="ANT_00220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00220"/>
    <dbReference type="eggNOG" id="ENOG5032SNM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090993_1_0_0"/>
    <dbReference type="OMA" id="WCVFDRD"/>
    <dbReference type="OrthoDB" id="1866297at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025591">
        <property type="entry name" value="RloB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13707">
        <property type="entry name" value="RloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="207" mass="24018" checksum="B6CE1C6B5BEA26A3" modified="2011-04-05" version="1">MARTPKPSGRKLSPKGTPLRKRSTKQRELRQRILIVCEGKQTEPNYFKRFRVNAVVEAFGLGRSPLDLVKYAQDYRKKEGFDQAWVVFDRDNVQASQFNQAISEAQKSGIKVAYSNPFFEVWFLLHYGYHNTPMNREKYIEKLSQNLKRPYQKNDSSLYDDLLSRQSTAISNAQRLLASYTPHDPAQDDPCTTVHLLVEELNKHLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYB3</accession>
    <name>E8MYB3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558456.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62058">
        <property type="protein sequence ID" value="BAJ62058"/>
        <property type="gene ID" value="ANT_00240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00240"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029428_0_0_0"/>
    <dbReference type="OMA" id="RCHAPMG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003227963" evidence="1">
        <location>
            <begin position="26"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="549" mass="59184" checksum="36AA5CDE151F48CA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE8</accession>
    <name>E8MYE8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplT</name>
        <name evidence="7" type="ordered locus">ANT_00590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558491.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62093">
        <property type="protein sequence ID" value="BAJ62093"/>
        <property type="gene ID" value="ANT_00590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00590"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_0"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="116" mass="13308" checksum="A1B33ED070541742" modified="2011-04-05" version="1">MARVKGGPKGHLRHKKILKMTEGYFGTRHRLFRRANEAMLKSLWYATRDRRVRKRDMRKLWIARINAAARLNGLTYSQFIHALKQAGIALNRKVLANLAVRDPKAFAAVVEKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI4</accession>
    <name>E8MYI4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62129">
        <property type="protein sequence ID" value="BAJ62129"/>
        <property type="gene ID" value="ANT_00950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00950"/>
    <dbReference type="HOGENOM" id="CLU_2894071_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="62" mass="6512" checksum="3036A5D621F8D9B6" modified="2011-04-05" version="1">MGGFIFSLRSGGETQAFASMSSTRSGIGIAHIPNGLGVVRSPQVHAQVLNLCHIPGDMPYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYI8</accession>
    <name>E8MYI8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560691.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22980"/>
    <dbReference type="EnsemblBacteria" id="BAJ64324">
        <property type="protein sequence ID" value="BAJ64324"/>
        <property type="gene ID" value="ANT_22980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22980"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="OMA" id="HCENEAD"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="30724" checksum="668D6DEC95B86545" modified="2011-04-05" version="1">MSKVAIVTDSTAYLPPELIRGYSIEVVPLHLIWGEKTYLDGVDITPKEFYERLATAKELPTTSQPSPAAFKTVYDRLLAAGYDVLSIHISSKLSGTMDSAIQAKAMLPGARIEIVDSLSTSMGMGFAVVEAARAAARGASLEECKAIAERGLRNVSVFFLVNTLEFLHRGGRIGGAAAFLGTALNLKPILELRDGRIEAIEKVRTITKATDRLLDIFAERARGKRPLRLAILHANAQEEAERLLERARQKVSVDDISEAVIVPVSPVIGTHTGPGCVGIAFMSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP6</accession>
    <name>E8MYP6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560748.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64382">
        <property type="protein sequence ID" value="BAJ64382"/>
        <property type="gene ID" value="ANT_23560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23560"/>
    <dbReference type="eggNOG" id="ENOG5031U0Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086377_0_0_0"/>
    <dbReference type="OMA" id="WASGINL"/>
    <dbReference type="OrthoDB" id="1828070at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="190" mass="20162" checksum="F17EE47CC47708D6" modified="2011-04-05" version="1">MEIFSAFGLSASAGLNAYIPLLIVALLAKFTPWIRLNEPWDALTSWWVIGLLVVLSVIEFFADKIPAVNHINDAIQTFIRPAAGAIVFAASTSVVKEIHPVLAISAGILVAGGVHAAKSLVLRPAVTAVSGGTANVPVSMAEDVISTILSILSVVVPVLIACILILVTTTILWMWLRKIRSTSSVPKTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYR3</accession>
    <name>E8MYR3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hisB</name>
        <name evidence="8" type="ordered locus">ANT_23730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64399">
        <property type="protein sequence ID" value="BAJ64399"/>
        <property type="gene ID" value="ANT_23730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23730"/>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726926_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="7">
        <location>
            <begin position="2"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="380" mass="41340" checksum="0C525D73D1EEB40D" modified="2011-04-05" version="1">MKAGVVVFEGFSSLDFYMVVEPLLSPKKIYLERLDICARVGEVYDSSDLHVFATRLAPDLSGYDWLIIPGGEGVWKLLDNPAFLDWLSTAADAGHLVALREGILLASAAGLLKGRTVASLPEWEERLRQDGAVPVRQPSVMDSHYLTAVDRRSVLALGEAIAAAIALNQPLQSIQGGSGETVYSSREVAVERNTGETQVKVRLNLDGSGVCQIQTGLGFLDHMLEQVAVHGLFDLWLQASGDLHIDPHHTVEDVALTLGMAFQQVLGDRKGIVRMASFTVPMDESLAMVALDFSGRPFCVFDALWNAPEVGGIPVTLMEHFFQSFAQTARCTLHARVLYGRDDHHRAEALFKALGRALAQAAQVDARRQGKVPSSKGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYV7</accession>
    <name>E8MYV7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560798.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24170"/>
    <dbReference type="EnsemblBacteria" id="BAJ64443">
        <property type="protein sequence ID" value="BAJ64443"/>
        <property type="gene ID" value="ANT_24170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24170"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276179_0_0_0"/>
    <dbReference type="OrthoDB" id="600220at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1153" mass="123691" checksum="7D69250AF53E1C3F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX3</accession>
    <name>E8MYX3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DnaA_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560814.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24330"/>
    <dbReference type="EnsemblBacteria" id="BAJ64459">
        <property type="protein sequence ID" value="BAJ64459"/>
        <property type="gene ID" value="ANT_24330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24330"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407508_0_0_0"/>
    <dbReference type="OrthoDB" id="1942521at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaA_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="674" mass="77169" checksum="2AD07F04666C381A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX7</accession>
    <name>E8MYX7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24370"/>
    <dbReference type="EnsemblBacteria" id="BAJ64463">
        <property type="protein sequence ID" value="BAJ64463"/>
        <property type="gene ID" value="ANT_24370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24370"/>
    <dbReference type="eggNOG" id="ENOG5033BFU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2465937_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="93" mass="10225" checksum="D4ECCFC8E1FB3733" modified="2011-04-05" version="1">MRLFLLVRDEDVSGVSGTGIVAEGVEFSDGTVAMRWLRRPFSVAFYGSIRDVVAVHGHGGRTRVKWLGEDQREGCAEWTKPSGVSIGLSEERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY3</accession>
    <name>E8MYY3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64469">
        <property type="protein sequence ID" value="BAJ64469"/>
        <property type="gene ID" value="ANT_24430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24430"/>
    <dbReference type="HOGENOM" id="CLU_2191493_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="108" mass="11231" checksum="D64A025159703BA6" modified="2011-04-05" version="1">MAVQPGGTCTHHRIGEPPAHLRRLEGEDYHVACQGACRSLPAVTSPGRLPMVSPAAPSDKGSPSLAPPGADDSAPLPPPYAADVSVAKTEFRRAGLEPAITHLPPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYZ2</accession>
    <name>E8MYZ2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative protoporphyrin oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558533.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62135">
        <property type="protein sequence ID" value="BAJ62135"/>
        <property type="gene ID" value="ANT_01010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01010"/>
    <dbReference type="eggNOG" id="COG4635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2230398_0_0_0"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="112" mass="12192" checksum="51678D0D780CCD7C" modified="2011-04-05" version="1">MPEKILIAYATKYGSTAGIATTLGEALGARGLQVDVRPVREVRTLEGYDAVILGSPVYMGNWLSEAVTFVRTHQAELSRLPVALFTVHMLNQGEDETSRAARQGYTAPVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ21</accession>
    <name>E8MZ21_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558562.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01300"/>
    <dbReference type="EnsemblBacteria" id="BAJ62164">
        <property type="protein sequence ID" value="BAJ62164"/>
        <property type="gene ID" value="ANT_01300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01300"/>
    <dbReference type="HOGENOM" id="CLU_1297672_0_0_0"/>
    <dbReference type="OrthoDB" id="2231665at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="212" mass="23413" checksum="007F5D8018E47F1D" modified="2011-04-05" version="1">MHWKRDLASKFFDGILPVIVLYLLWQTILLPMGILYHRSGGPGLMVYALALIAVAVYSFQRGLNTRSAETTRGWYGMAGGLVAWAATEFASMLSEGKLSGLDTAIALLLAILITTLMWRQYLPVGARFFLTTYLANGVGHILMTFFRLLAGTSPAAMLFFLILGYAAIAITLGGLIWIMFFSERRLQRMWAALIILLAGSAAVYIFRGGWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ42</accession>
    <name>E8MZ42_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_01510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558583.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62185">
        <property type="protein sequence ID" value="BAJ62185"/>
        <property type="gene ID" value="ANT_01510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01510"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="KVFSHEP"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="60"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="375"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="408"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="620" mass="68114" checksum="22C3CADF5B5BAC68" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ97</accession>
    <name>E8MZ97_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02060"/>
    <dbReference type="EnsemblBacteria" id="BAJ62240">
        <property type="protein sequence ID" value="BAJ62240"/>
        <property type="gene ID" value="ANT_02060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02060"/>
    <dbReference type="HOGENOM" id="CLU_195720_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="52" mass="5508" checksum="05E725177681ADBA" modified="2011-04-05" version="1">MLEERPLTACPSCGGEIDLTYADVGDTVICVVCGAELRVLSLDPPDVEEIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ98</accession>
    <name>E8MZ98_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_02070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02070"/>
    <dbReference type="EnsemblBacteria" id="BAJ62241">
        <property type="protein sequence ID" value="BAJ62241"/>
        <property type="gene ID" value="ANT_02070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02070"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="199"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="221"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="383" mass="43362" checksum="4FEE0846BEA1AA8C" modified="2011-04-05" version="1">MMGELSMALNQHLRQNLHLVETSTAPTLDEHFADLFNLSRLLNQTNRLEQILKTIARHSLSLLQVVYCRILTLEEDGRLITRLVEIDERLPELQRRRLERLPAALREYHRALHSQGVVVYQAYDFVYTPMVRQNLGLNDLNSLCLVPMRVADETIGLMVLGDHWRKEEALFNEERIRLAVMIADQAAAAIHRTLLNARLHESQVTAIRALVAMLEQRDLYTGDHSRRMTELAGKLAHQMGCPPEEVEAVRWAAILHDLGKVGIPDETLRKPAELSAEEWKLMKTHPLKGAEIILMLSGLEHVAMLVLAHHERFDGTGYPYGLSGNRIPLGARILAVVDAYTAMTDGRVYRPAISHPEALAELRRCAGSHFDPQVVEAFLALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC5</accession>
    <name>E8MZC5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_24470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560828.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24470"/>
    <dbReference type="EnsemblBacteria" id="BAJ64473">
        <property type="protein sequence ID" value="BAJ64473"/>
        <property type="gene ID" value="ANT_24470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24470"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_4_2_0"/>
    <dbReference type="OMA" id="LWLCGDS"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="entry name" value="PTHR46313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="481" mass="53242" checksum="5D2FDD1DCB355579" modified="2011-04-05" version="1">MRIVVIGAGIGGLTTAALLVKAGYSVTVLEAQTYPGGCAGTFFHKGYRFDAGATLAGGFQPGGPHARLAQLLGLSYPTHPISDAGWVVHLPNRRIYQWTDPEQWQEEVQRHFPFSRAFWKLQRFLANQVWDLSSRNAPLPPQSFHEFISLLKALRPGTITTLPFLFSRVKDFFPSKWTPEFKAFVDAQLLISAQTTSEDASLLYGSAAMDLPRRGIHTVKGGMGTLSEVLVDWIRRNGSEVLFRQEAVRVETNKREVHRVITRKGDVFTCDALVANVTPWGWAKLLGDALPVSIKKDLLKTGRMWGAFVLHLGVEADRVNTPITHHQIIGTLDRPLGETNSVFLSLSPLDDPTRAPSGMRAVTISTHTEPLGWFSLSEEDYQKRKEQYTEQCLSLVEREFPGFRSAVRLCLAGSPRTYAYYTHRPWGMVGGFPQSSILQARGPQSGFHNAWLVGDSVFPGQSTAGVTLGATRVANLILQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ7</accession>
    <name>E8MZJ7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyr_redox_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560900.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64545">
        <property type="protein sequence ID" value="BAJ64545"/>
        <property type="gene ID" value="ANT_25190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25190"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598057_0_0_0"/>
    <dbReference type="OMA" id="RFNFIGN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="457" mass="50612" checksum="2193268C733C1453" modified="2011-04-05" version="1">MEKIQPVTTHLVAVIGAGPAGLFASRELAENGVRVFLFNRDIKPGGLAEYGIYPTKLRMKAGLRTQFKQILERDGIEYYGNVTIGTQGDLTLEQLKAMGFSALLVAVGAQGTKQLGIPGEDLRGVYHAKDLVYHYNRLPPYSEKVFEIGKRVAVIGVGNVMLDITQWLLRVRRVDEVIAVARRGPAEVKFDPKELEHVINCLDVEAVEMELNRVTPQMVSLGQDPNQMRSLIRTLLEKDHVEEGCGGASFRLQFLASPVRILGDENGRVCGLEVEQTMLYRQDNGEVIARGMGKYITLEVDTVIFAIGDRVDPALGLPVEGNEFVKNPQPRFPVEGISYEAYDPAAQRPIQGVFVAGWARKASTGLVGIARKDGINAARAVLQYLGTLPFPESLSLETIRQQILNLPHPVVTLPYLKRLEEAERQRAEELGVEDFKFEHNLDMLAAMGLIKSLARET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ5</accession>
    <name>E8MZQ5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560958.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25770"/>
    <dbReference type="EnsemblBacteria" id="BAJ64603">
        <property type="protein sequence ID" value="BAJ64603"/>
        <property type="gene ID" value="ANT_25770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25770"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_3_0_0"/>
    <dbReference type="OMA" id="WDENKTA"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225179" evidence="2">
        <location>
            <begin position="25"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="567" mass="63426" checksum="27C771E762C44462" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT9</accession>
    <name>E8MZT9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wecB</name>
        <name evidence="3" type="ordered locus">ANT_02400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558671.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02400"/>
    <dbReference type="EnsemblBacteria" id="BAJ62274">
        <property type="protein sequence ID" value="BAJ62274"/>
        <property type="gene ID" value="ANT_02400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02400"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_1_0_0"/>
    <dbReference type="OMA" id="FWRRIPV"/>
    <dbReference type="OrthoDB" id="1117971at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="379" mass="41980" checksum="9D5BC064315780D1" modified="2011-04-05" version="1">MIRVLSIFGTRPEAVKMAPIVRLLAQTPGIESKVCVTAQHRQMLDQVLEVFNIQPDIDLNLMKPNQSLAQLTADIFTHLDPVLREVQPDWVLVQGDTTTVMAAALLAFYHRIRVGHVEAGLRTNDRYQPFPEEINRRIAGVVADLHFAPTEHARRNLLAENVPPQSIVVTGNPAIDALRWITAQPMPQEAEDLLARMDVRPGGRQLVLITAHRRENFGKPLEDICHALRALAEEYADRLALLYAVHLNPNVQEPVYRLLSGIPNITLTPPLDYLPMAHLMQKAHLVLTDSGGIQEEATSLGKPTLVLREVTERPEGVEAGVLKLVGTDPQRILREARLLLEDEQAYRAMAQAANPFGDGHAAERIVEALLKASQSASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N034</accession>
    <name>E8N034_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="17">BCAT</shortName>
            <ecNumber evidence="17">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">ilvE</name>
        <name evidence="18" type="ordered locus">ANT_03350</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 17">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 17">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 17">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6 17">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 17">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 17">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="17"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558766.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03350"/>
    <dbReference type="EnsemblBacteria" id="BAJ62369">
        <property type="protein sequence ID" value="BAJ62369"/>
        <property type="gene ID" value="ANT_03350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03350"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_3_1_0"/>
    <dbReference type="OMA" id="WRGSEMM"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050048">
        <property type="term" value="F:L-leucine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17 18" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17 18" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAJ62369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="34373" checksum="B744EBD38F5A33C9" modified="2011-04-05" version="1">MTDSQEYIWLDGELVESEKATLPFMTSALHYGLGVFEGIRCYETPRGPAIFRLAEHMERLIDSARILGFRDLPYTAEQLGEACKTVVRANRLTSCYIRPLIFFDSKVKNLNLDQGWARVGIAAWYWGAYLGEEALEKGARMNISSYTRHHPNVMMTKAKITGNYANSVLAKTESVRLGFDEAIMLDPQGYVAECTGENLFIVRNGVIYTPGTWAVLEGITRDALITVARDLGYTVVETQLSRDHLYIADECFVSGTAAEVVPVTEIDFRTIGNGRRGPVTHALQKAFHAVVHGEDPRYAHWLTTVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N054</accession>
    <name>E8N054_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_03550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03550"/>
    <dbReference type="EnsemblBacteria" id="BAJ62389">
        <property type="protein sequence ID" value="BAJ62389"/>
        <property type="gene ID" value="ANT_03550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03550"/>
    <dbReference type="HOGENOM" id="CLU_679058_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225185" evidence="2">
        <location>
            <begin position="25"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="405" mass="44517" checksum="91837DDE971CEBB8" modified="2011-04-05" version="1">MMKRRVFGCLLILLILLAFPTANAAQALQPRTPDLPPQTPQEVQQTESAPQTSALTALNLPPLKAVLIVGPIDGDNGSWTRQEIANMELAAQELEKNGVTVYRFYTPNNNWEQIKAAANGAHFLFYRGHGIYWSDMPYPTVGGFGLKDRMYSSAEIQRDLKLAKNAIVMIYACFSAGSASNDTIPVTQAEARRRVGEYSQPFFALGAGGYFADWFGNAFQQYVRFLFEDKTLGQAYQAFGDYEAGKTVQTTHPAFPSLPMWLGYDEWYEPKPQWNNAFVGDPNQTLESLFPPAMQVSSPAVVAMLESASVSQTASVRITASNGATFNWNATVVGSKPAWLTFTASGSSVQPMQITVQPASGTGTYEVQIQVNPVGMTLSNAPQIITVRLIQVNQIHRVMIPLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N064</accession>
    <name>E8N064_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_03650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558796.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03650"/>
    <dbReference type="EnsemblBacteria" id="BAJ62399">
        <property type="protein sequence ID" value="BAJ62399"/>
        <property type="gene ID" value="ANT_03650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03650"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_4_2_0"/>
    <dbReference type="OMA" id="MASSIWN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="64"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="184" mass="20409" checksum="B0C62A86A7F9C25E" modified="2011-04-05" version="1">MASSIWNWVQRWDDRWTPRFTLKPGGGWIWRSAAVLAHSGDSWFWVGALALVWLFTTGDWHRRAALLAAAVGVQALAVFALKQFIRRPRPEGEWGAIYRNVDPHSFPSGHAARAALLAVMGLGLGPQWFAVLLLIWAPLVSLARVATGVHYLSDVLAGILLGSLMGAGMLALSDWLMRLFPFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0A9</accession>
    <name>E8N0A9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561012.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26320"/>
    <dbReference type="EnsemblBacteria" id="BAJ64658">
        <property type="protein sequence ID" value="BAJ64658"/>
        <property type="gene ID" value="ANT_26320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26320"/>
    <dbReference type="eggNOG" id="COG5368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023287_0_1_0"/>
    <dbReference type="OMA" id="WISRNQA"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228018" description="Glycoamylase-like domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoamylase-like" evidence="3">
        <location>
            <begin position="231"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="462" mass="51785" checksum="89F0A7DB85642E0C" modified="2011-04-05" version="1">MNKLIVFLSLLAFVFSSCAVPSATLSPEPNPTVTASATSTPPLPTFTPTAEPSPVPSPTPTLATPEEVIAYEMKGAFDFFWEQANTDPDSPGYGLIRDRFPGSEGIASMASLGFGLTAYLIGVEKGYITREQAYERVSRTLDTLANMERVEGFYYHFVDMQTGKRAWQSEVSSIDTAILFMGVLSAGQYFGGEVQQKAQRLYDEVNWGWFLDESRQMFYMAYRPEKGFEGHWDFYAEQLMLYVLAAGSDTHPVDATPYYTFTRHTAKYGEGVKPFIHSWFGSLFTYQFSHAWIDFRGYTDQKGVDWFDNSVQASLAQVRFAEAMDAKYLTLGPNAWGLTACDGPKGYEGRYGAPPSGFDNKAHYVDDTVPPAGAIGSIVFTPEDSLRAMLHYYTLENLKGRYGFKDAYNLTARWYASDVIGIDKGISLLMLANYEDEMVWRVMMQNPNILKGLERLQLNKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F1</accession>
    <name>E8N0F1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64700">
        <property type="protein sequence ID" value="BAJ64700"/>
        <property type="gene ID" value="ANT_26740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26740"/>
    <dbReference type="HOGENOM" id="CLU_3179510_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="46" mass="5417" checksum="89378901B0846624" modified="2011-04-05" version="1">MDIPLDHIQVHRYSPPFYAFFKGIAIQEEETILKPYLWLLKSPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F4</accession>
    <name>E8N0F4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_26770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561055.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26770"/>
    <dbReference type="EnsemblBacteria" id="BAJ64703">
        <property type="protein sequence ID" value="BAJ64703"/>
        <property type="gene ID" value="ANT_26770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26770"/>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_1_0"/>
    <dbReference type="OMA" id="AFKPGNE"/>
    <dbReference type="OrthoDB" id="1035565at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="32451" checksum="1F3B7E1822C818B2" modified="2011-04-05" version="1">MDTLTLQSTIRMNNGVEIPRFGLGTFQSKAGEETYNAVRWALEMGYRHIDTAALYGNEEDVGRAIADSGIPREEIFLVTKVWNDDQGYESTLRALEASLRHLKTDYVDLYLIHWPVKGLRHETWKAMVEIYKQGKARAVGVSNYTIRHLEELLSNTELVPAANQIEFSPFLYRKALLEYCVQHGIVVEAYSPLARAQKLEDPRLTAMAQKYGKTPAQIALRWALQHDLVVIPKSVRKERILENASIFDFELSAEDMAEMDTWNEDYWTISESYNPECSPRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G4</accession>
    <name>E8N0G4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561065.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26870"/>
    <dbReference type="EnsemblBacteria" id="BAJ64713">
        <property type="protein sequence ID" value="BAJ64713"/>
        <property type="gene ID" value="ANT_26870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26870"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034061_0_0_0"/>
    <dbReference type="OMA" id="IDADNTQ"/>
    <dbReference type="OrthoDB" id="990092at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="2">
        <location>
            <begin position="192"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="271" mass="30392" checksum="D4212206E1225678" modified="2011-04-05" version="1">MDSEQSAIRSRRIAMLIDGDNAQPSLIGDMLAETSKYGTVIIRRIYGDWTTANMNGWKEVLQTYAIQPIQQFRYTIGKNATDSAMIIDAMDILYEDRVEGFCLVSSDSDYTRLATRIREKGIFVMGIGKSTTPRAFVNACDVFVFTENLQKKNLPAPKPRPQSASASRRKTEKNGKTEKQEEKAPAVESDALANLPLDLLRQAYDLAVGDDGWAFLGLMGTHLRQLDPSFDPRTYGFKQLSMLIKALPDLFETKVGKRGDGTFNVYVRLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I8</accession>
    <name>E8N0I8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561089.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27110"/>
    <dbReference type="EnsemblBacteria" id="BAJ64737">
        <property type="protein sequence ID" value="BAJ64737"/>
        <property type="gene ID" value="ANT_27110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27110"/>
    <dbReference type="eggNOG" id="COG2318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1179499_0_0_0"/>
    <dbReference type="OMA" id="RALWHEM"/>
    <dbReference type="OrthoDB" id="2087829at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="1">
        <location>
            <begin position="114"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="231" mass="26924" checksum="66DF9D0AA2C2E671" modified="2011-04-05" version="1">MLIRIGLENGFESRRSIAWALDYPGAFAYGRDGSEALLNMPQALVRYEHWVNRHAGEPRLNMSHLDLRLVETWEVYCINEAFEVVPEGLEINSFFRDDWRPLTEEEVRHGLDLLSWSRADLLAIVRDLPAEKLDQTYEGQRWSIRGILAHVATAEWWYLNRFGLMGERSSLPKDPFQRLEVVRQRLMEVLPSLAGSKQVLGVDGELWSPRKLLRRALWHEMDHIGHIVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N0</accession>
    <name>E8N0N0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03910"/>
    <dbReference type="EnsemblBacteria" id="BAJ62425">
        <property type="protein sequence ID" value="BAJ62425"/>
        <property type="gene ID" value="ANT_03910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03910"/>
    <dbReference type="eggNOG" id="COG3631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155955_1_0_0"/>
    <dbReference type="OrthoDB" id="1644255at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="126" mass="13855" checksum="97E8DF315C0A1837" modified="2011-04-05" version="1">MWMKLGKVEAPVRLALAFYEACNRQAIEEMLTLLSADCLFESPAAPCGSPLRGRDAIAAFWREFFAAHPGARFEVQDVFGAGFRSVARWTCTWKSPDGTAHSFCGVDVFRITGESIAEQVSFGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N7</accession>
    <name>E8N0N7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_03980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558828.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03980"/>
    <dbReference type="EnsemblBacteria" id="BAJ62432">
        <property type="protein sequence ID" value="BAJ62432"/>
        <property type="gene ID" value="ANT_03980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03980"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_0"/>
    <dbReference type="OMA" id="TVDHLYH"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="56"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="316" mass="33283" checksum="F3127034DDB66E41" modified="2011-04-05" version="1">MSETFAPSSRPFDLLVAGEINPDLILNGDVEPAFGQVEKCVDSATLTIGSSSVIFACGAARLGLRVAFIGKCGDDLFGRYMLEAMQERGIDTRAVIQIPDGHTGMSVILNRGSDRAILTYPGLIAALSADDIPDDLLGQARHLHIASYFLQTALQPGLPDLFRRARRLGLTTSLDPNYDPGASWQGIRDLLALTDVFLPNQTEACALTGTDDPAKAARTLGKQTGTVAVKMGTQGALGVQGEVMAHAPALTVPVVDTVGAGDSFDAGFLYGYLQGWTLERCLRLGAVCGSLSTRTAGGTAAQPTLAEALGFLEREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R9</accession>
    <name>E8N0R9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_04300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558860.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04300"/>
    <dbReference type="EnsemblBacteria" id="BAJ62464">
        <property type="protein sequence ID" value="BAJ62464"/>
        <property type="gene ID" value="ANT_04300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04300"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485434_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="361"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="561" mass="63313" checksum="E27623840B42E822" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T9</accession>
    <name>E8N0T9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2-oxoglutarate ferredoxin oxidoreductase alpha subunit</fullName>
            <ecNumber evidence="3">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558880.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62484">
        <property type="protein sequence ID" value="BAJ62484"/>
        <property type="gene ID" value="ANT_04500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04500"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_0_0_0"/>
    <dbReference type="OMA" id="DFIQGDE"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="247"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="371" mass="40616" checksum="F4C14CF0C9DD7689" modified="2011-04-05" version="1">MARELLKGNEAIAEAAIRAGLQAYFGYPITPQTELLEWMSKRMPELGRAFVQAESELAAINMVYGAACTGARVMTSSSSPGISLMMEGISYIIGTEVPAVLVDVMRGGPGLGNIAPAQSDYNQIVHGGGHGDYHLIVLAPASVQEAVDLTVLAFDLAEKYRTVAVVLLDGSLGQMMEPAELPPMRPVKTVYPEWAATGMMGKREKNILTSIYLNPPDEEQTNLRLLRRWQEVEANEIRFKEYFMDDARYVVVGFGSAGRVALSAVRAARAEGIPVGLLRPITLSPFPYAHIRKLAERVEGFLVVEMNAGQMLEDVRLAVSGQKPVEFYGRLGGVMPFPDEILAEIQRIASGGLTLEGHPRERWLQRMNGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0X9</accession>
    <name>E8N0X9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558920.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04900"/>
    <dbReference type="EnsemblBacteria" id="BAJ62524">
        <property type="protein sequence ID" value="BAJ62524"/>
        <property type="gene ID" value="ANT_04900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04900"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130332_1_1_0"/>
    <dbReference type="OMA" id="RTETIHE"/>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="93" mass="10863" checksum="3AB4A576D15F7789" modified="2011-04-05" version="1">MKLRDPQLQETLIQRLRRIEGQIRGVEGMLENQRDCREILQQVSAVQAALRSFSRSLLEEYAVTCLLDEEARTDPRLAEKNLRELIELITRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z7</accession>
    <name>E8N0Z7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558938.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62542">
        <property type="protein sequence ID" value="BAJ62542"/>
        <property type="gene ID" value="ANT_05080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05080"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_2_0"/>
    <dbReference type="OMA" id="GNYRAGF"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="20030" checksum="CF92959F358DA696" modified="2011-04-05" version="1">MSWQIDTAHTQIQFTVRHLMISKVRGWFEKFSGTVNLDESNPENTSVDVVIDAASINTREPQRDAHLRSADFLDAEHYPHLTFKSTRVERTGERTARLYGDLTIRGVTKPVVLDVTFNGMLTNPWGMTSAGFSATTTINRKDWGLEWNVALEAGGWLVGDEVEIAIEAELIKVVAEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N126</accession>
    <name>E8N126_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosidase</fullName>
            <ecNumber evidence="3">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558967.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05370"/>
    <dbReference type="EnsemblBacteria" id="BAJ62571">
        <property type="protein sequence ID" value="BAJ62571"/>
        <property type="gene ID" value="ANT_05370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05370"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_0"/>
    <dbReference type="OMA" id="DWVYVVP"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="442" mass="51269" checksum="04167F8D391E72D4" modified="2011-04-05" version="1">MPKADYVFPNGFLWGTATSSHQVEGNNTNNDWWAWEQQEGRILHGHRSGLACDWWDGRWREDFDRAAETGQNAHRFSIEWSRVQPAPDRWDEDAIDHYRDMLRGLRDRALLPLVTFHHFSLPLWLAERGGWENEETPALFARYVRKCMEAFREYTNFWITINEPNVYAYEGYIAGLFPPGKKDLTAAMRVMANLVRGHALAYREIHAVQREARVGLALAIRPLLPAGPLKFLDGIPAKIAGQFFNEAFPGALKDGKLRLITRTVPIPEAQGTQDFVGVNYYTVDMVRFDLLRPQEMFGHRFYPADAPLSDTGFIAHFPEGMFLTLKWAKSFNLPIIVTENGVEDADDHLRPRYLAEHIHQVWRAANFNWQIKGYFHWTLVDNFEWERGWTQRFGLWGLDVDTQRRIRRPSVDLYASICQKNALTYDAVAQYAPEALPRLFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N140</accession>
    <name>E8N140_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative succinate dehydrogenase membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sdhD</name>
        <name evidence="8" type="ordered locus">ANT_27570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561131.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64783">
        <property type="protein sequence ID" value="BAJ64783"/>
        <property type="gene ID" value="ANT_27570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27570"/>
    <dbReference type="HOGENOM" id="CLU_1976953_0_0_0"/>
    <dbReference type="OrthoDB" id="2147690at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="126" mass="13803" checksum="5499F7EAC2840215" modified="2011-04-05" version="1">MTNAPLSAPKPGEGALLWAVKIFSGVLILLILILHFLVNHYWAPNGLLSHAEVVAYYQNYPIVPIMEGFFLIFVVAHSLLGVRSILLDLRPSPRVLRGVDGMLILIGVTASVYGIWLLIRVTGWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N149</accession>
    <name>E8N149_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64792">
        <property type="protein sequence ID" value="BAJ64792"/>
        <property type="gene ID" value="ANT_27660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27660"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104207_0_0_0"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="169" mass="19318" checksum="F924A278DE3E965B" modified="2011-04-05" version="1">MDLNIEIREVGTKDISQLERLFPQGGAEKHARRLVRQQNGSAVYLIAFLAEMPVGHLLLKWDGARDEAVRANRPVPCPDLEDLFVREEYRQQGIATQLLRHAEDLARQCGYAEIGLAVGLENPDARRLYDRLGYREAGFGTYRVHGMYVDEQGALCTWEEECVYLVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N169</accession>
    <name>E8N169_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561159.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27860"/>
    <dbReference type="EnsemblBacteria" id="BAJ64812">
        <property type="protein sequence ID" value="BAJ64812"/>
        <property type="gene ID" value="ANT_27860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27860"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543642_0_0_0"/>
    <dbReference type="OrthoDB" id="1418315at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2807" evidence="2">
        <location>
            <begin position="307"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="501" mass="53711" checksum="22665316E6C70825" modified="2011-04-05" version="1">MNDSRARIVLSVLLILMGLAFLAFEVAGWAGITLTWPLGIIAVGGLLFLAMLFGGRGLGVLAIPASIVTMLGAIFWVQERFDLYQTWAYAWALIIVSVGFGLLIYGLWSNLPEMRRSGWKTMQVGIILFLIFGAIFELLFSLVGVGARLGGGLFWALILAGLGVLLLAIRLSRFILRRGEAGGEWDFFWPLMFITFGVLWLLVSVSALPSQNLTAIFRLWPAFLVVFGLLVLVGHRYPLANLALGLITAAVIVWAVWTGAAARLPVRSGLLFIPSISAQGSVTEVITGNGQMASETREVRGVSSLLVEGASEVTLVQGAKEELVIEADENLLPYLTSRLVAGKLVLGIQPGVGISPTRSIRYRLTVKSLNEIEASGASKIMLDGWEGKDLSLRIEGASEFSLKGLTVDRLEVTIDGLGKVTAAGIAPALDVEISGSGTLDAGDLRTERADVRVDGLGNVTLWVTDELETRISGAGSVAYYGSPRVKPRNDGLATLRSLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N198</accession>
    <name>E8N198_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_28150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561187.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64841">
        <property type="protein sequence ID" value="BAJ64841"/>
        <property type="gene ID" value="ANT_28150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28150"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
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        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="180"/>
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    </feature>
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            <end position="223"/>
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            <end position="351"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="382"/>
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    </feature>
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            <end position="413"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="453"/>
            <end position="474"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ64841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="509" mass="54023" checksum="197DDC0E94AFA58D" modified="2011-04-05" version="1">MSRLTRISILLAVCFALDKAAAFLRQVIIARQFSFSAELDAFNVANNVPDLIYAVISGGALAMALIPVLSATLTTQGREALWRVFSHVANLVFLVTAALSIVVALVAVPLVRTEVGIAPGFGMQQQMVVVNLMRLNLIATLIFSLSGLVMSALQANQHFLFPALAPLFYNFGQIFGALILSPAEGYRIAGITLPALGMGVYGLVSGVILGAFLHLGIQIPALIRYRFRWSMGLGLDNPQVVQVLKLMAPRILTVGFVQVIFLVRDNLASRLPEGAVSALTYGWMIQQVPETLIGTAIATAMLPTLSELAAQKQEGLFHESVQRAVRVLIGITLPIAAVLAIGLGPLMQAVFALNDTHAATLLWATRGFLAGLMGHSLMEVAARSFYARQRPIPPMLAGFGNMLLYIGLGSALYRPLGAAGISLTDAVCFTAQAVFLLVLLGRQTGRFIHLGDSLTRAVFAALAGGGVAFALLNAQVLSSPLLGSALAMAGGGVVALPFIFKELKLLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A5</accession>
    <name>E8N1A5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NPCBM_assoc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ64848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64848">
        <property type="protein sequence ID" value="BAJ64848"/>
        <property type="gene ID" value="ANT_28220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28220"/>
    <dbReference type="eggNOG" id="COG1470">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051163_0_0_0"/>
    <dbReference type="OMA" id="GMAVMRF"/>
    <dbReference type="OrthoDB" id="601520at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="A-galactase_NEW3"/>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="NPCBM_assoc"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228591" description="NPCBM_assoc domain-containing protein" evidence="2">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="266"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="386" mass="40905" checksum="9D07493DF18248EC" modified="2011-04-05" version="1">MKRLVTFLMTLLLIFSLGASVQTAHAQDADVLKLTTTYPGVVVGLGEGVSFDLKVSVSDAPHIVKLEVTQLPEGWTATLRGGGKTIQSVYVEPGKDVTVDLRLDQPKEVKSGTFNVLVTAAADGLKAQLPLQVTVKEKQPARLTLTTDLPTIKGGPTSTFSYDVTLKNEGDEDMTVSLSASAPAGFQVTFRLGAQDVTSFPINARETKRLTVRAEPYVELPAGTYPLKFTVQSGEVQASLDLQAEVTGQATLSLTAPDGRLSAQVRSGRETPLKLVVRNTGTAPARGIKLSSSEPSGWKVAFEPESIEEIAAGEEVTVTVKVKPADNALAGDYMLTLRAAPTGGSTKSADFRITVLTSTLWGLVGIILIAVAVGVVLLAVMRFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H8</accession>
    <name>E8N1H8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62583">
        <property type="protein sequence ID" value="BAJ62583"/>
        <property type="gene ID" value="ANT_05490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05490"/>
    <dbReference type="HOGENOM" id="CLU_523423_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="520" mass="57454" checksum="D9753C52F54E37B5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K2</accession>
    <name>E8N1K2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_05730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05730"/>
    <dbReference type="EnsemblBacteria" id="BAJ62607">
        <property type="protein sequence ID" value="BAJ62607"/>
        <property type="gene ID" value="ANT_05730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05730"/>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_1_2_0"/>
    <dbReference type="OMA" id="INHGIGM"/>
    <dbReference type="OrthoDB" id="1115239at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="500" mass="52207" checksum="994691CF5EF42217" modified="2011-04-05" version="1">MGWQTHNVLNCSFIQNHLLKTYSSEEGSHMATTAKKPAVMGYLPNDVPPFGQMVLLGFQHVLTMFPATVLCAILMKFPVSTVLTITGLGTVVALLGSKFAMGKYIPLYYGSSFSYIAAVTAIMQAKGVEGPVAPPEVISVVTAGFIATGTINIIVGLIIRLSGGKEAIDKILPPIVTGPVACTIGIGLGAAALNMASGACCGVTDPVMQLKWWAAATVTLLAAFIFSVYLQGKGFIGMLPILLAAIFGYIVAIPLGLVDFSQFGKEALIRAPTITFPVFNDPLTATVIVGVGIMAIATIPESTAHLYQISLYVDHLAEEQGREKYGLARYIGLNLMLDGLNDLVNGLFGSTAGTNYGENNSLMVISRNYSGPSLLAAGVIAILLGFIGPLAEAVASIPTAVSGGLAIYLFGVIGMQGIALMMAEKVNLYDPKSLAIGAAILIIGIGGNIGFNGGFLPIPLLQGVFPYGWPAIATGAVVGIVLNLITMAWKPPMERAAVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q7</accession>
    <name>E8N1Q7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559057.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06280"/>
    <dbReference type="EnsemblBacteria" id="BAJ62662">
        <property type="protein sequence ID" value="BAJ62662"/>
        <property type="gene ID" value="ANT_06280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06280"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1591196_0_0_0"/>
    <dbReference type="OMA" id="YTVARQD"/>
    <dbReference type="OrthoDB" id="1291710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="167" mass="19078" checksum="95CE528DEB38B1F3" modified="2011-04-05" version="1">MTLQPEAERDLIILEHIEQNPDATQATLAAQLGVAVGTINWHLKRLIEKGYIKVRRAERRKLRYIITPEGIALRARLTMDYIQTSFRLYRLVRQRTIEALTQVQEHGIRMVRVVGDGDVAEVCRLTCLERGMQVVEDEHAPALTIQGLKIVLMGDGFDHKEEENHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W0</accession>
    <name>E8N1W0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06810"/>
    <dbReference type="EnsemblBacteria" id="BAJ62715">
        <property type="protein sequence ID" value="BAJ62715"/>
        <property type="gene ID" value="ANT_06810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06810"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="DHKDIAG"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="149"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="254" mass="28589" checksum="E752E23D61233C17" modified="2011-04-05" version="1">MPSRLESPGVQGHTILLRHGRQKKPVSSDKAKILLIEGKRADHPSFLTGLTRKGYDVESVPNGNSAVEQLNTFEPDVIIIDAASMRTSGKRICHALRLRAGDIPILLIVDPQSAGKNPRESLADVVLTTPLTLQKLLNRLRPLVPAQSKHVLQAGPIWLDPAQRLVRVGNRQSSLTPRLVTILRILMEHPGEVIERNSLFQQAWNTDYTEDTRTLDVHISWLRRAIEVDYRHPQLIKTIRGVGYRLDIEETPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W1</accession>
    <name>E8N1W1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06820"/>
    <dbReference type="EnsemblBacteria" id="BAJ62716">
        <property type="protein sequence ID" value="BAJ62716"/>
        <property type="gene ID" value="ANT_06820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06820"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3057959_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="53" mass="5932" checksum="D844A86AABBE7F1A" modified="2011-04-05" version="1">MINGTMARTGNFRQNGCMSELVNYVEARGYLERVPNPQDRRASIVRLSAMGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X1</accession>
    <name>E8N1X1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28920"/>
    <dbReference type="EnsemblBacteria" id="BAJ64918">
        <property type="protein sequence ID" value="BAJ64918"/>
        <property type="gene ID" value="ANT_28920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28920"/>
    <dbReference type="eggNOG" id="ENOG502ZJIW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040680_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228606" evidence="1">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="267" mass="28371" checksum="D9FB766E325B1103" modified="2011-04-05" version="1">MRVWEVWALSLFLLGLTACAVQSPQSALLANPTPTVTLTPTRTPVWFPPTDTPTPIPTATPVPTLEMRPGVGEVVLTDDFSGANWQTGETEAGRIALGKGELTLAVTAEKGVLTSMRSGALPGDGYLEITVQASLCRPEDVYGVLVRASSPRDGYRILFNCGGSLRVERLKNGEIALLQDWTPVAGLPSGLLPARLGVWMAGQDLRLFVNGVYQFSLRDPVWTEGSIGAYARAAGASPLTVAFSALEVRALDVSRIPTATPFPSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N258</accession>
    <name>E8N258_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29790"/>
    <dbReference type="EnsemblBacteria" id="BAJ65005">
        <property type="protein sequence ID" value="BAJ65005"/>
        <property type="gene ID" value="ANT_29790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29790"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1145364_0_0_0"/>
    <dbReference type="OrthoDB" id="11182at200795"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="26407" checksum="02D5B88A9181EBD5" modified="2011-04-05" version="1">MFFSMRKVLLVFLILAGFAAAVLGAWAVRRTAQGGSLRDERVISFIRSPKLHADWVLEAGTRCADAPFRMPTRGFIGYVWGDSFRPGHHHSGLDIFGGTAPGETPVYAAYSGYLTRLPEWRSTVIIRIPSDPLQPERQIWTYYTHLADPQGNSLIDAAFPPGTQDVFVEAGTLLGFQGNFSGTPGAPVGVHLHFSIVRDDGEGHFLDEREMENTLDPSPYFGMTLNAEGLGMGIPACLPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N264</accession>
    <name>E8N264_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561355.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29850"/>
    <dbReference type="EnsemblBacteria" id="BAJ65011">
        <property type="protein sequence ID" value="BAJ65011"/>
        <property type="gene ID" value="ANT_29850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29850"/>
    <dbReference type="eggNOG" id="ENOG5032SXZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437895_0_0_0"/>
    <dbReference type="OMA" id="YHFALWR"/>
    <dbReference type="OrthoDB" id="825108at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043728">
        <property type="entry name" value="DUF5671"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18920">
        <property type="entry name" value="DUF5671"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5671" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5671" evidence="2">
        <location>
            <begin position="165"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5671" evidence="2">
        <location>
            <begin position="324"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="642" mass="70447" checksum="9FA0347D9D476E35" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N272</accession>
    <name>E8N272_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_29930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561363.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29930"/>
    <dbReference type="EnsemblBacteria" id="BAJ65019">
        <property type="protein sequence ID" value="BAJ65019"/>
        <property type="gene ID" value="ANT_29930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29930"/>
    <dbReference type="eggNOG" id="COG2116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036896_3_0_0"/>
    <dbReference type="OMA" id="MIWFPIM"/>
    <dbReference type="OrthoDB" id="1834167at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015499">
        <property type="term" value="F:formate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023999">
        <property type="entry name" value="Formate_transptr_FocA_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00790">
        <property type="entry name" value="fnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04060">
        <property type="entry name" value="formate_focA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01005">
        <property type="entry name" value="FORMATE_NITRITE_TP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="30306" checksum="394F062241799A17" modified="2011-04-05" version="1">MLTNGEISLDALLPPEMAKKAEAIGVKKASLDLLSMFALAVLAGAFIAMGAIFSTTVSAGSTLPYGVTRLLAGLAFSLGLTLVVVGGAELFTGNVLILMAFANGKVSFGALLRNWLVVYLGNFVGSLATAGLVFLSKQYTFGNGVVGLTALNIANSKSALEFVPAVALGILCNALVCLAVWLTYSARTTTDKILAILPPITAFVAAGFEHSIANMYFIPLGLFIKNWAPASFWGLKALEEAGKTAGSFTALTWGNFFVNNLIPVTLGNIIGGGVLVGLVYWFVYLRGHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C3</accession>
    <name>E8N2C3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_06950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06950"/>
    <dbReference type="EnsemblBacteria" id="BAJ62729">
        <property type="protein sequence ID" value="BAJ62729"/>
        <property type="gene ID" value="ANT_06950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06950"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021886_0_0_0"/>
    <dbReference type="OMA" id="GAMTAFW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="36"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="279" mass="31251" checksum="ECE6A35DE7B14F4E" modified="2011-04-05" version="1">MLPPIERRASGARLFWMTVWGRAYPRVVGMQRERSWVFFDVFLPLLSVAAYVFVYRAIRAPEEYVGFVVLGGAMTAFWMNILWSMSSQLYWEKEQGNLALYIISPTSMMAILLGMAIGGLFATLLRATAILLIGSWLFQVQYTIVSFWKLFAVFALSMVALYGLGMMSASMFLLLSREAWHLANLAMEPIYLVTGMYFPVKNLGFWAAAGASLIPLTLGLDAMRQLIFANGAALGFLSVEVEILGLVILSVVFLIGARYLLVVIEKLAIQEGRLTENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2E9</accession>
    <name>E8N2E9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ethanolamine utilization protein EutL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eutL</name>
        <name evidence="4" type="ordered locus">ANT_07210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62755">
        <property type="protein sequence ID" value="BAJ62755"/>
        <property type="gene ID" value="ANT_07210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07210"/>
    <dbReference type="eggNOG" id="COG4816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1270774_0_0_0"/>
    <dbReference type="OMA" id="ACFYSAN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030983">
        <property type="entry name" value="EutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009193">
        <property type="entry name" value="EutL_PduB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012290">
        <property type="entry name" value="EutL_PduB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04502">
        <property type="entry name" value="microcomp_EutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="BMC circularly permuted" evidence="3">
        <location>
            <begin position="113"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="23397" checksum="D0F199C10E5B37F1" modified="2011-04-05" version="1">MAILDPIRPNILSARIIPNVHPSFAKEMGLRPDQKSLALITCDIDDCLYVSLDEATKKAEVEVVYAHSFYAGSAHASGPLSGEIIGILAAPNPAEARAGLNACIEYATEYAYFLSANEENTLAFFPHTISRSGSYLSQAAGVPEGTPLAYLIAPPIEATYAIDAALKAAEVELRVWWKPPSETNFSGALLSGTQSACRAACQAFQDAVLEVARYPKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F1</accession>
    <name>E8N2F1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ethanolamine utilization protein EutM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eutM</name>
        <name evidence="3" type="ordered locus">ANT_07230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62757">
        <property type="protein sequence ID" value="BAJ62757"/>
        <property type="gene ID" value="ANT_07230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07230"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064903_5_3_0"/>
    <dbReference type="OMA" id="HSEVEMI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="95" mass="9759" checksum="116BE512FB629A43" modified="2011-04-05" version="1">MTIQMIALGMIETKGLVGAIEAADAMVKAANVKLIGKEYIGGGYVTVMVRGDVGAVKAATDAGAAAAQRVGELVSVHVIPRPHSDVEMILPKVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I1</accession>
    <name>E8N2I1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62787">
        <property type="protein sequence ID" value="BAJ62787"/>
        <property type="gene ID" value="ANT_07530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07530"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1239483_0_0_0"/>
    <dbReference type="OMA" id="GPKIFCS"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="231" mass="25454" checksum="ABEC8AE4D2C47B0B" modified="2011-04-05" version="1">MVSEKLLYWASKPVVKTYSNVMLDLDVERRSALPRGAKIFAPNHPTTTDPFFVAAMVGEQSFILINNLLFQVQVLGTYLRRAGHIPVKAGEGQQAIDRALEYLEKGYNIIIFPEGALSPEEGGFCKPKTGVARIALASGAPVIPVGIHLDKSRVHTVRSTVKGQVEYGRWYLRGPYAMTAGAPLYFHGDPEDRELVRSVSNTVMHHIIELARESEIRLTRTPDALGTLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2M8</accession>
    <name>E8N2M8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_08000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559226.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08000"/>
    <dbReference type="EnsemblBacteria" id="BAJ62834">
        <property type="protein sequence ID" value="BAJ62834"/>
        <property type="gene ID" value="ANT_08000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08000"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076018_0_0_0"/>
    <dbReference type="OMA" id="NCNMAFR"/>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="27450" checksum="30FAB47246F4E49C" modified="2011-04-05" version="1">MKLVTWNCQGAFRRKYPALAALQPDLAVVQECESLERISWKQGNAPTHTFWYGEKPTRGVGIFSWTQTSFRVKEGFDTSIHYAIPVEVEAPIPFHVIAVWTMKHADWRLAYSGQAYRALGVYREFILSADTVILGDFNSNQRTAPRGRVGSHAVLAANLHTLGLISAYHFATGEKSGNETHPTFFHGRKTEQAGHIDYVFIPSRWIRRLKSVQVGNPGEWLAYSDHCPVMVEFVPKYPNRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2R2</accession>
    <name>E8N2R2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561403.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30360"/>
    <dbReference type="EnsemblBacteria" id="BAJ65062">
        <property type="protein sequence ID" value="BAJ65062"/>
        <property type="gene ID" value="ANT_30360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30360"/>
    <dbReference type="HOGENOM" id="CLU_181383_1_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021320">
        <property type="entry name" value="DUF2905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11146">
        <property type="entry name" value="DUF2905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="77" mass="8248" checksum="34B97FA39AFB7E24" modified="2011-04-05" version="1">MALERIGTGLMLLGLILLLVSGLLWLAGRFLPDLSRIPGTIRIEGGGVTCIFPLLASIVLSLILTVLLNVIARLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V1</accession>
    <name>E8N2V1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Terminase_6C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561442.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30750"/>
    <dbReference type="EnsemblBacteria" id="BAJ65101">
        <property type="protein sequence ID" value="BAJ65101"/>
        <property type="gene ID" value="ANT_30750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30750"/>
    <dbReference type="eggNOG" id="ENOG502ZAXN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043667_0_0_0"/>
    <dbReference type="OMA" id="VVGNTAH"/>
    <dbReference type="OrthoDB" id="851275at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035421">
        <property type="entry name" value="Terminase_6C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17289">
        <property type="entry name" value="Terminase_6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_6C" evidence="1">
        <location>
            <begin position="302"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="506" mass="55646" checksum="0BBECE8CCDA29659" modified="2011-04-05" version="1">MDELRLLRQTLSDVCAFARLSGVRLRPYQAQVARAIVDAVLHDRGLSFVVMFPRQSGKNEVQAHLEAYLLTLFSGTSAEMVKASPTLRPQSLTAMRRLERVLNANPLTRGRWRRESGNTFRLGQARIHFLSAAPGASIVGATASLLLEVDEAQAVSIEKFDTELAPMTASTGAVRVFWGTAWTASTLLGRELRLAQAEQARDGVRRVFRLTAAEVIADHPRYARTVERAIQQLGRNHPAVRTQYFSEEVDAAGTLFPEERLALLRGTHPWQDAPLPGRTYAFLLDVGGTAPVQLPLMDDYAGNRRDSSALVIVEVEPPQDGRPAPRYRAVHLCQWTGVSQTRLFEQVLALARQWSPRRIVIDATGVGAGLADFLDRALPGRVVRFVFSSASKSDLGYRFLEVVESGRFHLPQADEGRAQALVERFLAQCRGCTYEVDASPHQRLHWGVPEGARHPGGGGYLHDDLLMAGALCALLDRMAWGWSGATSAHAGIIPARDPLKELDGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W7</accession>
    <name>E8N2W7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_30910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561458.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30910"/>
    <dbReference type="EnsemblBacteria" id="BAJ65117">
        <property type="protein sequence ID" value="BAJ65117"/>
        <property type="gene ID" value="ANT_30910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30910"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_0"/>
    <dbReference type="OMA" id="RKEWYAN"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="358" mass="38967" checksum="D462ED8D8C9BAC36" modified="2011-04-05" version="1">MLQFITRRLILLFPVLIGVLLVTFVIVRAIPGDPCKVMLGERATEEKCAEFKERYGLNDNLLVQFGRFLVNMGRGDLGVSIRFGQPVVNLIAARLPMTIELTIGAMLFSTIVGVFLGIISALKRNTIVDTITMVIANIGVSMPVFWLGLVLAYVFALLLKDTPFFLPPSARLTSGLALTQLADYWGLKDLSGFQKFVVDFLTHSLLVNALATGNWKLLGDGLRHLILPSVAVGTIPMAIIARMTRSSLLEVLGQDYIRTARAKGLPYNKVISKHALSNAMIPIVTIIGLETGALLSGAVLTETVFNLPGVGTALVGAILARDYPVVQGFTLVVAMVFILVNLLVDISYAYLDPRIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X2</accession>
    <name>E8N2X2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Class-I fumarase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_30960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30960"/>
    <dbReference type="EnsemblBacteria" id="BAJ65122">
        <property type="protein sequence ID" value="BAJ65122"/>
        <property type="gene ID" value="ANT_30960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30960"/>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041245_0_0_0"/>
    <dbReference type="OMA" id="IETYPTH"/>
    <dbReference type="OrthoDB" id="972093at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ65122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="32174" checksum="A5155D3D9D2254B0" modified="2011-04-05" version="1">MEHLKEPLIELIRLAATNLPPDVEKALRQALEREEPGSAARGALETILKNVELARKRSTPICQDTGTPIFYVYHPEGWSTRKLRQVIEEAVAEATKRSYLRPNSVDSLTEKNTGNNLGDEHFPTIHFEEVDGDTLTVDLMLKGGGCENVGAQYSLPGRVGGGVPAGRDLEGVRRVVLDAVHKAQGQGCSPGILGVAIGGDRGSGYYASKEVLFNELDNPNPDPELEKLEERITEEANQLGIGPMGFGGNTTVLDTKITGLHRLPASFFVTVSYMCWAYRRRRMIWKDGTAVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y8</accession>
    <name>E8N2Y8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheA</name>
        <name evidence="8" type="ordered locus">ANT_31120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561479.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31120"/>
    <dbReference type="EnsemblBacteria" id="BAJ65138">
        <property type="protein sequence ID" value="BAJ65138"/>
        <property type="gene ID" value="ANT_31120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31120"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_7_0"/>
    <dbReference type="OMA" id="MKGEARM"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="296"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="552"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ65138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="691" mass="75411" checksum="FC68BE1B47CF17A5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N310</accession>
    <name>E8N310_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561501.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31340"/>
    <dbReference type="EnsemblBacteria" id="BAJ65160">
        <property type="protein sequence ID" value="BAJ65160"/>
        <property type="gene ID" value="ANT_31340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31340"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_8_0"/>
    <dbReference type="OMA" id="VIMPDEA"/>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="105" mass="11564" checksum="AB680E595A94981F" modified="2011-04-05" version="1">MNIYVGNLPFSANEDDLRSAFAAYGTVTSAAVIKDQFSGQSRGFGFVEMPNQAEAEAAIQGLNGKELKGRALRVNEARPREERRPGGDRPRRPGGGDRRNDRRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N346</accession>
    <name>E8N346_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">hutU</name>
        <name evidence="13" type="ordered locus">ANT_31720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561536.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31720"/>
    <dbReference type="EnsemblBacteria" id="BAJ65196">
        <property type="protein sequence ID" value="BAJ65196"/>
        <property type="gene ID" value="ANT_31720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31720"/>
    <dbReference type="eggNOG" id="COG2987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018868_0_1_0"/>
    <dbReference type="OMA" id="LVGDWAN"/>
    <dbReference type="OrthoDB" id="100619at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="136"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="346"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ65196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="550" mass="60252" checksum="56BE9930CDA6C25C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B1</accession>
    <name>E8N3B1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tilS</name>
        <name evidence="9" type="ordered locus">ANT_08910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559317.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08910"/>
    <dbReference type="EnsemblBacteria" id="BAJ62925">
        <property type="protein sequence ID" value="BAJ62925"/>
        <property type="gene ID" value="ANT_08910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08910"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_1_0"/>
    <dbReference type="OMA" id="QQYGMNA"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="396"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="476" mass="54241" checksum="FEED289F5E41B75D" modified="2011-04-05" version="1">MSLEERVLHNAQERCRISPESPLVLGVSGGADSLCLLDVLHRAGFNLIVAHFNHRLRPEAESEADWVCAQAQQRGLRVELGQGEVLAMAKEQGMSIEEAAREARYSFLFSVAHQVQAQAVAVAHTASDQVETVLMHLIRGTGHKGLTGMPYRGFLNQFSTTTPLVRPMLSIWREEVLAYCHERGLTWLEDPSNRDVRFTRNRLRNEVLPLLKQVNPRVEEAIWRLSTLLAEEDDVFENAFQQAWNQCVLEQSSKQIVLSRERVQSLSPALQREVLRWSLSLLRPALRDLDFDTVNRAMQFVQQPTQSRHIHLVAGLGLRLEGEHLIVDDETFIQSLPSDFPQMPPQAQYVLPVPGSLVLPNGWSIEVQRVDVLPDSWDEVSRWEAFISGDALGEALEVRPFRPGERFQPLGMGGKSRKVSDFWVDVGLPRRLRSGWPLVFAQDEVVWIPGFRLDHRWRVTPETRSVYRLQIRREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C3</accession>
    <name>E8N3C3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pyruvate, water dikinase</fullName>
            <ecNumber evidence="3">2.7.9.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.9.2" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09030"/>
    <dbReference type="EnsemblBacteria" id="BAJ62937">
        <property type="protein sequence ID" value="BAJ62937"/>
        <property type="gene ID" value="ANT_09030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09030"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005950_0_0_0"/>
    <dbReference type="OMA" id="WTRKIAA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="835"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="915" mass="102061" checksum="F282282770DB85D8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3D2</accession>
    <name>E8N3D2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Haem_bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559338.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62946">
        <property type="protein sequence ID" value="BAJ62946"/>
        <property type="gene ID" value="ANT_09120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09120"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120447_0_0_0"/>
    <dbReference type="OMA" id="FYLPAHP"/>
    <dbReference type="OrthoDB" id="1935300at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025992">
        <property type="entry name" value="Haem-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14376">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01235">
        <property type="entry name" value="Haem_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Haem_bd" evidence="2">
        <location>
            <begin position="14"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="163" mass="18414" checksum="889906367B0E6343" modified="2011-04-05" version="1">MKNKVFLFGSLFILIVFGVLQVIPVEAVQKNPAVIAEPAWDSPQTREMFMRACGDCHSNETAWPWYSRIAPASWLIVRDVREGRNKLNVSEWGIRKNEADEVRKVIENGSMPPWFYLPMHPEARLSAQEKQALILGLENSLGVGEDATGKTGKENENKTEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E9</accession>
    <name>E8N3E9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_09290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559354.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09290"/>
    <dbReference type="EnsemblBacteria" id="BAJ62963">
        <property type="protein sequence ID" value="BAJ62963"/>
        <property type="gene ID" value="ANT_09290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09290"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_510694_0_0_0"/>
    <dbReference type="OMA" id="NTCMISI"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016116">
        <property type="term" value="P:carotenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045892">
        <property type="entry name" value="CrtISO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46313">
        <property type="entry name" value="PTHR46313"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="535" mass="61447" checksum="C1FFD74E19ED008D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H3</accession>
    <name>E8N3H3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559378.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62987">
        <property type="protein sequence ID" value="BAJ62987"/>
        <property type="gene ID" value="ANT_09530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09530"/>
    <dbReference type="HOGENOM" id="CLU_1479173_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="182" mass="20164" checksum="0FAFAC1C91127760" modified="2011-04-05" version="1">MKTRNLLFFSICLTVLFPAMGFALQGMYPAVGLNLIMGVLWLGLTLKEIPWSTPAFFLLMCMENALLPLFGISPFLALLSVVSGLASWDLHAFMNRITVLKEPVVLYRFEQHHLSRLGLTLAGGTVLGVLGLSIHFRLGFFLAFILGMALLVIFWALITRIAPAPQRTPGASPFPEESREEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I1</accession>
    <name>E8N3I1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559386.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09610"/>
    <dbReference type="EnsemblBacteria" id="BAJ62995">
        <property type="protein sequence ID" value="BAJ62995"/>
        <property type="gene ID" value="ANT_09610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09610"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046841_0_0_0"/>
    <dbReference type="OMA" id="FGYLIMM"/>
    <dbReference type="OrthoDB" id="1155696at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="399" mass="44663" checksum="E1740C728412F486" modified="2011-04-05" version="1">MSKVWIVFFHEYLRHVKTKRFLFGLLSLPLTILLTSIIAVGAIVVTTDLRPVGAVDQSGLFQNAQPYSEKKEDPLSVEVLPFPNEETARKALDSGEIQGYYVIQPDYLATGKVRAVSQTGLDKSANDAFSKFLLTHLLKNEDPLVRERMLEGSQVSLKSPTEENKYSTRTPFEPFAVLILGMIFFFAINIIGNYLLRALVDEKENRTMEIILTSLSTDQFMIGKILGNLSVGMTQIFFWFAIPILMGVFALTRIPLLRTINIDLTPFWLMMLLAFPAFIMVAALMTLAGATATESREAQQIASLFSLPFMIPFYFLQIFLEHPDSPLSIGLSLFPFTSLIGLPLRALATSIPTWQSVLAIGLMVLSAVGSIWLASRAFRLSMLRYGKKLSLLEIFRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M3</accession>
    <name>E8N3M3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsJ</name>
        <name evidence="6" type="ordered locus">ANT_10030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559428.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63037">
        <property type="protein sequence ID" value="BAJ63037"/>
        <property type="gene ID" value="ANT_10030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10030"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_0"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="102" mass="11840" checksum="53E9EC902B980F89" modified="2011-04-05" version="1">MAKQRIRIRLKAFDHRVLDQSAKRIVETAERSGARVVGPVPLPTKIERYTVRRSTFIDKDSHEHFEIRTHNRLIDVIDPDAKTIDMLMRLNLPAGVDIEIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P4</accession>
    <name>E8N3P4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">secY</name>
        <name evidence="11" type="ordered locus">ANT_10240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559449.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63058">
        <property type="protein sequence ID" value="BAJ63058"/>
        <property type="gene ID" value="ANT_10240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10240"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_0_0"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="214"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="241"/>
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        <location>
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            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="425"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="448" mass="49372" checksum="036D91212684DC43" modified="2011-04-05" version="1">MKRSAWRYLWKSVDIRQKLLITFLLLVIYRLAANIPVPGVNTEVIRGLLQGSGGAQSFLGLLDLLSGGTISNFSILAMGVYPYITAQIILQLLVPIIPALEQRLKDNPREGQIWMEKWTIILTIPMAFLSAIGQINIFGSLLQGGIAAILPNYGWSGANLLPTLTVILTMMGGTMFGIWLGQLISEYGIPKQGLSLIIFAGIVARIPANLLSILSDQQNGWWMLLVILAILVLTIFAIVYVQQGRRNVPVVFPGRRVGNRMSMPVHSNLPLMVNMAGMIPLIFAQAILTFPSMLASYFILSKTEWVANAARDIQRLFSSQSALYIIIYFLMVVLFTFFYTDVLFQQQNYGENLKKQGAQIQGVLRGEATQKYLSKVQRRITLPGALFLGLVAVLPYIVHALLPANAGAGLLLISAAGLLIVVGVVRDTFTIIDTELKLHGYQESLIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3U3</accession>
    <name>E8N3U3_ANATU</name>
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        <submittedName>
            <fullName evidence="10">Transport ATP-binding protein CydC</fullName>
        </submittedName>
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        <name evidence="10" type="primary">cydC</name>
        <name evidence="10" type="ordered locus">ANT_10730</name>
    </gene>
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        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ANT_10730"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
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    </dbReference>
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        <property type="term" value="P:glutathione transmembrane transport"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="43"/>
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            <end position="178"/>
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    </feature>
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        <location>
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            <end position="267"/>
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            <end position="305"/>
        </location>
    </feature>
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            <end position="571"/>
        </location>
    </feature>
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            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="583" mass="64443" checksum="445F423BD109962C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V5</accession>
    <name>E8N3V5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_10850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63119">
        <property type="protein sequence ID" value="BAJ63119"/>
        <property type="gene ID" value="ANT_10850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10850"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_283967_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
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    </dbReference>
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        <property type="entry name" value="GAF"/>
    </dbReference>
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        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
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        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="542"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="870"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1095" mass="120441" checksum="9D1D1948E46A11CB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W9</accession>
    <name>E8N3W9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559523.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63133">
        <property type="protein sequence ID" value="BAJ63133"/>
        <property type="gene ID" value="ANT_10990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10990"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_16_0_0"/>
    <dbReference type="OMA" id="QISIAVM"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="144" mass="15956" checksum="D0F42E7C46348FDA" modified="2011-04-05" version="1">MAAIEEIINFYSRVPLFRSLNKRQLEVLAKRTLERDYAAGTAILTQGKGGEGFFVVYKGKVEIQRMRSDGTSAVVNTLGPGDFFGEMALLDDGPRTATAVAVEPTVCLVLPRWDFLAVLRDDAEMAIVILEEMAKRFRIALDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N423</accession>
    <name>E8N423_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_11530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559575.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11530"/>
    <dbReference type="EnsemblBacteria" id="BAJ63187">
        <property type="protein sequence ID" value="BAJ63187"/>
        <property type="gene ID" value="ANT_11530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11530"/>
    <dbReference type="HOGENOM" id="CLU_665069_0_0_0"/>
    <dbReference type="OrthoDB" id="2051485at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="413" mass="46651" checksum="C1B7F7CC8103727C" modified="2011-04-05" version="1">MNRSRNQALLLILMILFLGILLAGVTWSNYQYTQKNPGGNDFLVHWVGTRVLFYEGISPYSDEAALRIQTLAYGRPARPGEHELRVAYPLYSVVFFLPFALISDFNLARAVWMTVLEASLVGISLLSLRLCRWKPSPFMLAGLLIFSLLWYHGLRPLINGNAVILVALFITGGLLALRDGADELAGVLFAFATIKPQVVVLIVAFLLLWGIGQRRWRFVGWLVGTVGLLSLAAGLIFPDWIIQNLREVLRYPAYNPPGTPGAAFAQWWPSFGARLGWALTFLMALMLIVEWRSGLRAEFRGFLWTALLTLNIAQWIGIQTDPGNFVVLFPGIILAFALMYERWHKGAAIASSIILLVLFVGIWAIFLSTVQYGDQPVQSPVMFFPLPFVMFVLLYWVRWWAFHPLGAWMGWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D2</accession>
    <name>E8N4D2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Formamidopyrimidine-DNA glycolase</fullName>
            <ecNumber evidence="19">3.2.2.23</ecNumber>
            <ecNumber evidence="19">4.2.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">mutM</name>
        <name evidence="19" type="ordered locus">ANT_12620</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="19"/>
    <dbReference type="EC" id="4.2.99.18" evidence="19"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559684.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12620"/>
    <dbReference type="EnsemblBacteria" id="BAJ63296">
        <property type="protein sequence ID" value="BAJ63296"/>
        <property type="gene ID" value="ANT_12620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12620"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_1_3_0"/>
    <dbReference type="OMA" id="GVHLRMT"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAJ63296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="271" mass="30766" checksum="D4D5E4851A9E9A84" modified="2011-04-05" version="1">MPELPEVQTIVSVLRDGGRGAPSILGKQITAANVAWQKTLAMPDLFTFQQNITGEEIRDIRRRGKFIWIILQSAHLFIHLRMSGDVRVEPSTSPLQLHDRLWLEFSDGLRLVFNDPRKFGRVWLAENPQDVIGDLGPEPLDESLSPTQFHQRLTKNRRQLKALLLDQNFLAGVGNIYSDEALFLAKLHPKRSSDSLSPEESARLLQAIRQVLEEGIRKNGASIDWVYRGGEFQNSFRVYQRTGEPCPICGTPIERITVSQRGTHFCPSCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4H4</accession>
    <name>E8N4H4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glutamate-ammonia-ligase adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glnE</name>
        <name evidence="4" type="ordered locus">ANT_13040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.42" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63338">
        <property type="protein sequence ID" value="BAJ63338"/>
        <property type="gene ID" value="ANT_13040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13040"/>
    <dbReference type="eggNOG" id="COG1391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2844">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006233_1_1_0"/>
    <dbReference type="OMA" id="RIDMRHI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="684"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1219" mass="140023" checksum="F8868E63F40F3818" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I4</accession>
    <name>E8N4I4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559735.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13160"/>
    <dbReference type="EnsemblBacteria" id="BAJ63348">
        <property type="protein sequence ID" value="BAJ63348"/>
        <property type="gene ID" value="ANT_13160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13160"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865075_0_0_0"/>
    <dbReference type="OMA" id="GFWPRRS"/>
    <dbReference type="OrthoDB" id="2167731at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="321" mass="33602" checksum="A49144F6B9B485C6" modified="2011-04-05" version="1">MNIKFRWIGFAVVVVFLFALSGCVSTTSVFSGNGAVIGQSFILREGETWDQDLSIIGGSAVLEKGSVVNGDVALIGGTLLVDGTVTGDISAMGGVISLGSHAVVEGDIVTLGANLNRDTGSVVKGQFQNDFPSFSFPVQPVTPRFGIFDTLMNIFWRVFQAFALGALAVLVALFMLQPLERVGTTMQSTPVQSGVVGFLTFLVGLGVLLVMAITIIFLPLSLLGILALGLAWIYGWLATGLLTGEKIAELFHTSWSGPVSAGVGTLVLSLMANLLGAIPCVGWMIPFVVTMIGLGAVILSRFGTQKYPVPVPVVPSSSAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X9</accession>
    <name>E8N4X9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63493">
        <property type="protein sequence ID" value="BAJ63493"/>
        <property type="gene ID" value="ANT_14650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14650"/>
    <dbReference type="eggNOG" id="COG3255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128031_0_0_0"/>
    <dbReference type="OMA" id="WEGDIIF"/>
    <dbReference type="OrthoDB" id="1936597at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="143" mass="16286" checksum="B19744F9C83DF274" modified="2011-04-05" version="1">MPKEELCMSIPFPSDQWIKAMMEDLNHSSSYEEAAKNWEGDFVFVIEPGGKLDKPVRLYMDLWHGKCRNAYQIPDGEVVNSAFRLSGPVAVWKKVMTKQLDPMQAMMTGQLKLTGNMAMVMRNVRAAKELVESCTRIPTEFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z3</accession>
    <name>E8N4Z3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rplY</name>
        <name evidence="6 9" type="synonym">ctc</name>
        <name evidence="9" type="ordered locus">ANT_14790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559889.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14790"/>
    <dbReference type="EnsemblBacteria" id="BAJ63507">
        <property type="protein sequence ID" value="BAJ63507"/>
        <property type="gene ID" value="ANT_14790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14790"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_2_1_0"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="98"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="210" mass="23342" checksum="027127DDC520DDF0" modified="2011-04-05" version="1">MEKIVLQAQRRTLERTAKALRREGYLPAVMYGAHFPSTPILLDAHNAGLKLAKVSSSTLVYIELDGETHAALVREKQRDYIKNRLLHVDFQVVSLTEKIRTTVSLHFEGVSPAVKDYNGVVVTSLDEVEVEALPQDLPERIVVDLSKLARIGDTIHVRDLEVAKGVKVLNDPDEVVVVVSTTTEEVEAPAEGELSEPEVIERGKKEEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z6</accession>
    <name>E8N4Z6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14820"/>
    <dbReference type="EnsemblBacteria" id="BAJ63510">
        <property type="protein sequence ID" value="BAJ63510"/>
        <property type="gene ID" value="ANT_14820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14820"/>
    <dbReference type="eggNOG" id="COG1432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065313_0_0_0"/>
    <dbReference type="OMA" id="ANADMDL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="1">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="302" mass="34060" checksum="9A224B68CD00816F" modified="2011-04-05" version="1">MAFIKDVAIQINCKFLDNCKGKISCRESVLNSKGVFVDVANIYLNGGQRMQYDVLREFACRDHAEAIRLNAYVTYDVERAEDDEEYRKGAQNFHGALRDLGYKVIVKDIHWYTDVNGIRVAKANADLDMAVDALTQSDYLDRVLIASGDGDFVQVVRALQNKGCRVEVVGLDNVSNRLKAEADFFISGYLIPDLIPVDYGGKYETPPAWGELGSRVRGWCYWHSDQGFGFFRFLKEISPNLWITDTRNPDSPYGTVFFHDSALPSTINPANLPNRNMIFEFELAKSEKGAGVQAIEIELTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N590</accession>
    <name>E8N590_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_15760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15760"/>
    <dbReference type="EnsemblBacteria" id="BAJ63604">
        <property type="protein sequence ID" value="BAJ63604"/>
        <property type="gene ID" value="ANT_15760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15760"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766486_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="205"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="347" mass="40016" checksum="2A553DB0FBF1454E" modified="2011-04-05" version="1">MKKNEVSRRDFLKLIGLGLGSLAFRPFLVDSSLGAGGDIFRVATYSVSVYKEPNDKSPILYQRYRDELINVYEEVISPYGPGYNPIWYRVWRGYVHSARLQKVKFQTNPVIQDIPKGGRLAEVTVPFTQSMRYLPWQKKWEPVYRLYFESTHWVTGVEQGPDGRPWYRIHDELLEFHYFVPAEHLRLIPDEEFTPISPQVKAWEKTIDVSIARQELICYEGGKEVLRSRVSTGVSRWNPDPTSIPTETPTGEFHIFSKMPSKHMGNGQVTADIEAYELVGVPWTSFFVETGVAIHGTFWHRNWGTPMSRGCVNVPTDIAKWIFRWTTPICEPGVWEQKGYGTLVVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D7</accession>
    <name>E8N5D7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63651">
        <property type="protein sequence ID" value="BAJ63651"/>
        <property type="gene ID" value="ANT_16250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16250"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549411_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="496" mass="57290" checksum="B859AF4C789763A0" modified="2011-04-05" version="1">MEVFPISGRGNRAIMFLMNFLDKSVSLRLFLLSLLLVLLAPFPSDWRDRQDWEIARRAQQDHGYLVQGEALRDIFQRHPWRQDIYEPLGVGAFLRGDDVLAFEYLWAAYRQGFISSQGQEILVKELLRQSKKEDAVQILMQIELPANCQFLSKYADTKRDLSFQDWLAILEKWNEKCPEEPFVLYQWGLFRIVENYHEGINCIKKAAQIQPEYQRVVSLLEEVNALSLSNQNHAYRLTLLGRALINLREYEEARLALQKAVEIQPVYAEAWAFLGEAKLELSDTTGKDDLKRAISLNPRSVISRVLYSLYLSREGNLEQAIEEMQQVLKIEPEQSIWYLELGRLTAKSGNLFEAYSYYEQATSLDPDNSLVWKSLAQFCVTYDFDVSGKGLFSAREALKLSPLDADAHKVMGDVLFKQGDFASAERFWVRTLQLNPSHAEAFLALGQLYLQENRLGEAQKMLENVFLFASQEETKLIAARLLERYFQVPLLTKNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G5</accession>
    <name>E8N5G5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_16530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560058.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16530"/>
    <dbReference type="EnsemblBacteria" id="BAJ63679">
        <property type="protein sequence ID" value="BAJ63679"/>
        <property type="gene ID" value="ANT_16530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16530"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025379_1_0_0"/>
    <dbReference type="OMA" id="YWEVLAK"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="243"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="420" mass="46702" checksum="257D0CF49D9BD96E" modified="2011-04-05" version="1">MTIQYWQKKVQQWFTTPEISSDIQRRNFINVQVDAIGVGIASAAAPFLPVFLTRLHASSFEVGLLTSMPAITGLILSIPLGQFLQRQRQIVPWFSLARLLVIACYAMTGLITFVLKEHAAVIGILAIWAFATFPQTLLSISFNVVMNSVAGPVGRYELMTRRWSILGLTTTLTVILVGQALDRIKSFPLNYQIVFLALSIGGLISYYFSSHLNLPPQEIPQERPASLREGLREFLHLILAEKPFVAFNLKRFVFSIGTTMAAPLFPLYFVRQLHAPDSWIATINTAQTAILILGYFLWTRQSRRYGSRRVLLATTFGVSLYPVLTGLTHTVWPIPFYAGLAGIFQAGLNLVFFDELMRTVPEKYSAIFVSTAQSIQYVSSIIAPFIGTSLASVLGFNAALIISGAVSLIGFLLFTIDRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P4</accession>
    <name>E8N5P4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560136.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63758">
        <property type="protein sequence ID" value="BAJ63758"/>
        <property type="gene ID" value="ANT_17320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17320"/>
    <dbReference type="eggNOG" id="ENOG5030JAW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942145_0_0_0"/>
    <dbReference type="OrthoDB" id="1674847at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="33728" checksum="86B127BD22FCD6D4" modified="2011-04-05" version="1">MKQISKTALENYRAITFRTHPGYRLTNPEEALTFIQQRGYVLFWPCQGIEFPSLWAAVAGNRPVADEHDDPGHITWSWKDEWLGKHLVYYGRVIRRKNTFISLDLLPYFYALSPNYGNPYEDYLIDYSAGKLSAEAKAVYEALIKEGALDTISLRKAARLSSRASDSAFNRALEELQITFRVVPVAVSQAGAWKYAFVYDLTARHYPDLVDKAHPISEWDARRKIIQNALESLGAARISDLNRIFQWEKSLIERTCESLVERKAILKNISLDESSSDYFCVPQFVEKTSALTLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P7</accession>
    <name>E8N5P7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560139.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63761">
        <property type="protein sequence ID" value="BAJ63761"/>
        <property type="gene ID" value="ANT_17350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17350"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_0"/>
    <dbReference type="OMA" id="YVGDRFP"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="298" mass="33336" checksum="DBDBE53D00BC334C" modified="2011-04-05" version="1">MFLITGATGFIGRHLVPHLVEMGHSVRVLLRPSPLTPLLPEKVPVEVVICAPSDERGIQSALKGVSHVIHLASAEHSESPEIFLSQEKAFAEILVQAALRSRVERFIYLSHLGADRLSAFPALQAKGWVEKIILQSEVPYTIVRSALVFGAGDHFTLPVATAMRKSPSVFFLPGEGRVSLQPLWIGDLVMALSLLLDDPRAENQVFSIGGPEYLTFYEVCRSIRDFLGLRRVFISLSPGLLRFFSRKYSTRRQSMFLPLYLLDYLAADRITSLDTLPRFLGIMPERFTHRLHYLKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R7</accession>
    <name>E8N5R7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_17550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560159.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17550"/>
    <dbReference type="EnsemblBacteria" id="BAJ63781">
        <property type="protein sequence ID" value="BAJ63781"/>
        <property type="gene ID" value="ANT_17550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17550"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_0_1_0"/>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="OrthoDB" id="299689at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="510"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1008" mass="114913" checksum="273B389B9B1195C3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T0</accession>
    <name>E8N5T0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560172.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63794">
        <property type="protein sequence ID" value="BAJ63794"/>
        <property type="gene ID" value="ANT_17680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17680"/>
    <dbReference type="eggNOG" id="COG2047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893223_0_0_0"/>
    <dbReference type="OrthoDB" id="834483at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="311" mass="35758" checksum="5DC959701F2869E2" modified="2011-04-05" version="1">MGNEVQILVEPVPQAQYMILGWRQWADAGAVSSGLPVYLIEKYQGKLVAQINPHGYYLFQIPGTHDLIRPVIHFHNGFPQSLEVPENHFFLINRGTTSILVFIGDEPHLNVEEYVQAILKVAKLFGVQKMIGLGGVYGEFPYDKERDISGSYSLQEMHQEVEDLSLRLTNYHGGVSIGSYLCKRAGDEHLPYIGMYAMVPYYDLSPLLNIEQTLRIENDYMAWLGILRRVNYLFKTDFDVLDLAQKSRKLIREVSQEIQELSGQMPEAGIQAYFENLSKNFRENPFIPLEDVWEEHLRKILKKMEDEGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W7</accession>
    <name>E8N5W7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_18050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560209.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63831">
        <property type="protein sequence ID" value="BAJ63831"/>
        <property type="gene ID" value="ANT_18050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18050"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_3_0_0"/>
    <dbReference type="OMA" id="DIQAYYI"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="298" mass="31883" checksum="A6F7814D559B6A2A" modified="2011-04-05" version="1">MSKLVGGIEAGGTKFICAVGSGPDDIRAEIRIPTTQPEETLGKVIAFFKEQQEKYREQLRSIGIACFGPIDLNPHSSTYGFITSTPKPGWKNTNVVGAIRKALNLPIAFEHDVVGAAIGEAAWGAAKGLSDFIYITIGTGIGGGILVNGNPIHGLVHPEVGHMRLPHDLKKDPFLGNCPYHGDCFEGLASGPALEKRWGMPGYQIPDDHPAWSLEAEYIALAVSNLILTTSPQKIILGGGVMQRSHLFPVIRQKVLGILNGYVQARALLDDIEHYIVPPGLGNRAGILGSLAMAQQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y0</accession>
    <name>E8N5Y0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M20 family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560221.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63844">
        <property type="protein sequence ID" value="BAJ63844"/>
        <property type="gene ID" value="ANT_18180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18180"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="OMA" id="EWHHPAF"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="190"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="398" mass="43304" checksum="B5175AF178B193EB" modified="2011-04-05" version="1">MELKVIMESLRQDAQNLASYLIEVRRDIHRNPELGFQEVRTASLVARTLTDLGMEVSTGIARTGVVALLDSGKPGPTILVRFDMDALPIQEQNSHEYVSQIPGVMHACGHDAHVAIGLGVAKLLAAYRENLRGRVKFMFQPAEEGLGGAKQMIREGVLEQPRPDYALAMHVWNEKPVGWVGVKPGALMAGADSFRILIEGKGGHGAIPHQTADPIYAMAQIITAIQSIVSRNVSPLETAVVSVGSVKAGDAHNIIPQTGEILGTIRTYSEPVRDLVLNRLQVLVEGIAQALGCRATIKINDVTPAVVNDEMVAKIVQNAVARMMPEMVNDTSCQTMASEDMAYVLREIPGCYFFVGSANSDKGLSFPHHHPRFDIDEEVLWRSVAVMSAAVMELAWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N623</accession>
    <name>E8N623_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560264.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18610"/>
    <dbReference type="EnsemblBacteria" id="BAJ63887">
        <property type="protein sequence ID" value="BAJ63887"/>
        <property type="gene ID" value="ANT_18610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18610"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_3_2_0"/>
    <dbReference type="OMA" id="IHMTSGL"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="281" mass="31005" checksum="329A5577B89C31CA" modified="2011-04-05" version="1">MIKIVADTTSCLTLEEVQKRGIYYVPQIIVIGEETYRDDTEMNAIEFLQRQRTSPILPKTAAPPPALYTPIFQEITEQGNSALVLAPSTQVSGTYRGASVAAQDFPNTDIRIIDTQLIAGGLGQLVLAAQEWTERGLSMDEILQRVEAMRKRHRVYFVVDTLDYLYKGGRIGTAKHLIGSLLQMKPILTLQDGHVASFESQRTQKRAIARLKEIVLSECPPGPQSRLNIMHGDALELAQSLAQELGPALNIPVEQIPIYDLTPAILVHSGPGVIAISYFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N695</accession>
    <name>E8N695_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_19330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560332.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63959">
        <property type="protein sequence ID" value="BAJ63959"/>
        <property type="gene ID" value="ANT_19330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19330"/>
    <dbReference type="eggNOG" id="COG2133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_291640_0_0_0"/>
    <dbReference type="OrthoDB" id="232572at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="322"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="495"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114854" checksum="D3CEEC6D5D0714B2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXE0</accession>
    <name>E8MXE0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 5">Acylphosphatase</fullName>
            <ecNumber evidence="3 4 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_19950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560392.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19950"/>
    <dbReference type="EnsemblBacteria" id="BAJ64021">
        <property type="protein sequence ID" value="BAJ64021"/>
        <property type="gene ID" value="ANT_19950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19950"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_1_0_0"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="99" mass="11190" checksum="03D0E34F97DAAABA" modified="2011-04-05" version="1">MENNARLHALVIGHVQGVGFRAFVYDRAQSLQLTGWVRNTYEGDVEVTAEGPRETLETFLNDLRRGPRSAHVVDVRVQWEQATGQFPKFSILPTSYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG1</accession>
    <name>E8MXG1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_20160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560412.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20160"/>
    <dbReference type="EnsemblBacteria" id="BAJ64042">
        <property type="protein sequence ID" value="BAJ64042"/>
        <property type="gene ID" value="ANT_20160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20160"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_0_2_0"/>
    <dbReference type="OMA" id="DSGMICF"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012749">
        <property type="entry name" value="WecE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02379">
        <property type="entry name" value="ECA_wecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="383" mass="43494" checksum="41CE886FFBE771C5" modified="2011-04-05" version="1">MSNTSQNIRIPFNRLTVVGEELTYLQQAIESGHVSGDGTFTKRCHTLLEETLGVPKALLTTSCTHALEMSALLLNIQPGDEVIVPDFTFVSTINAFVLRGAKPVFVDIRPDTLNLDETLLESKITSKTKAIVPVHYAGVGCQMDTIMDIANRYGIAVVEDNAHGLFARYRGKYLGTFGQLATQSFHETKNFSCGEGGALLINDSQFIERAEILREKGTNRSRFFRGQVDKYSWVDIGSSYLLSDMLAGFLLGQLEAREIIQSRRKEIWETYFHELQSWASQNQVRLPFIPEHCDQSYHMFYLLMPDLESRQRLIQYLKERGILSVFHYLPLHLSEMGRKYGGKLGDCPVTESISDRLLRLPFYYSLRSDEQAQVIQAITQFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ7</accession>
    <name>E8MXJ7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20520"/>
    <dbReference type="EnsemblBacteria" id="BAJ64078">
        <property type="protein sequence ID" value="BAJ64078"/>
        <property type="gene ID" value="ANT_20520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20520"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_0"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="37292" checksum="ADA58376E1CE8A50" modified="2011-04-05" version="1">MMLNQVVQEMLPRIEEELRQVIEATSSPNTPQLSAMLRYHLGWEGEGTGQEAQGKRIRPLLVLLSAQAVGGKWEQALPAAAAVELVHNFSLIHDDIQDQSTLRRGRPTVWVKWGIAQAINAGDAMFTQAFWALNRLEQTISSQTALEASRILHQVCLRLTEGQYLDLAYEKVDTLPLEAYWPMVGGKTAALLGGCVELGGLCSHASPEQRTALREFGENLGLAFQVLDDWLGIWGDAALTGKSTESDLVSGKKSLPVLYGLANSETFAQRWRRGKITSEEVHDIAGLLQDCGAEAFTLNTAEELTQKALDALNRAFEQNRERSLLLSELAKKLLSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM3</accession>
    <name>E8MXM3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20780"/>
    <dbReference type="EnsemblBacteria" id="BAJ64104">
        <property type="protein sequence ID" value="BAJ64104"/>
        <property type="gene ID" value="ANT_20780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20780"/>
    <dbReference type="HOGENOM" id="CLU_2010502_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="123" mass="13777" checksum="CDFC0C37BD20943B" modified="2011-04-05" version="1">MGGFSTETRQRIAQEFEMAFTARRQGNEGRARVCARRAAGVAAKEYLLQQGMGTPALNAWDALNLLVRQSLSQEMQHSVQILTMRVNEEFSLPVEADVIQEAQFLCEALEKLLVSKGNNEYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP9</accession>
    <name>E8MXP9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glgA</name>
        <name evidence="10" type="ordered locus">ANT_21040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21040"/>
    <dbReference type="EnsemblBacteria" id="BAJ64130">
        <property type="protein sequence ID" value="BAJ64130"/>
        <property type="gene ID" value="ANT_21040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21040"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_5_0"/>
    <dbReference type="OMA" id="TWCPWYM"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="14"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="308"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="493" mass="55347" checksum="B662E401FA61F6B0" modified="2011-04-05" version="1">MISGKGWKMAQPFRVLMVSAEAEPYVKVGGLGDVAGSLPKALLKLPKDVLEGNSLDVRLVLPFHPVIAREVAAQEPLVVVQVPKREGTVEARIYLSEIAGYPVYLIDGEPISRASTVYSLDSAQDADKYIFFSLAVLEMIQALGWKPHVLHAHDWHTAIAVYELARRRDQDDFYRGIKSLFTIHNLPYMGAGAEKVLPEYAIPPSEDIRLPWWGKSLPLPMALSTADFLSTVSPTYSREMLTSEFGCGLEDFLRSRSSTLFGILNGLDTQIWNPQEDSFILRKFSAENPRDRLPNKQALLDQLGLVPEEEAPLLGLIGRFDRQKGIDLAIGALRMMAEQPWQAVLLGSGDPVLEESARNLEREFPERVRVVIKFDLRLSHQIYAGADMLLMPSRYEPCGLAQLIAMRYGCIPVARATGGLRDTISDLPDPSMSTGFLFNEATPEALAEALRRAIVAYEDSTGWEMRQRNAMQQDFSWSRSAQEYYRLYRLLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXS8</accession>
    <name>E8MXS8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21330</name>
        <name evidence="2" type="ordered locus">ANT_23980</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="1">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560529.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21330"/>
    <dbReference type="EnsemblBacteria" id="BAJ64159">
        <property type="protein sequence ID" value="BAJ64159"/>
        <property type="gene ID" value="ANT_21330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64424">
        <property type="protein sequence ID" value="BAJ64424"/>
        <property type="gene ID" value="ANT_23980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21330"/>
    <dbReference type="KEGG" id="atm:ANT_23980"/>
    <dbReference type="HOGENOM" id="CLU_1861041_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="137" mass="14405" checksum="6BC52A3E0F0AC308" modified="2011-04-05" version="1">MRRWIQRLGSRRAELDEAAFALPVLLLVSLGLVNLALLGFAAINAANAAEYGARMGSMAQTAPVSAAYAAAQNKLSAVRVGNYTVSVTGGGQPGSPITVSVTYRVPNYFGGLGRLFGVSTPAEFQGRANAIFRQEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT2</accession>
    <name>E8MXT2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21370</name>
        <name evidence="2" type="ordered locus">ANT_24020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="1">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560533.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21370"/>
    <dbReference type="EnsemblBacteria" id="BAJ64163">
        <property type="protein sequence ID" value="BAJ64163"/>
        <property type="gene ID" value="ANT_21370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64428">
        <property type="protein sequence ID" value="BAJ64428"/>
        <property type="gene ID" value="ANT_24020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21370"/>
    <dbReference type="KEGG" id="atm:ANT_24020"/>
    <dbReference type="eggNOG" id="ENOG5031EA7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162083_4_1_0"/>
    <dbReference type="OMA" id="MPVILRF"/>
    <dbReference type="OrthoDB" id="1948244at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="78" mass="9270" checksum="9E424B4047E0B83D" modified="2011-04-05" version="1">MPTVLVIGPYRFFFVSLDYGEPPHIHVQREKFVAKFWLDPVQLEKSGGFKAQELNQIGKLVQENQTYLLERWYEHFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV3</accession>
    <name>E8MXV3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64184">
        <property type="protein sequence ID" value="BAJ64184"/>
        <property type="gene ID" value="ANT_21580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21580"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2566371_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="81" mass="9292" checksum="07141773F3E5E8A1" modified="2011-04-05" version="1">MPEYVGIRMLKARAGEIVRNVQRGMRYVVSIRGRPVALIIPVEPVPELPEQDSWEALYQAGSLLEWKTQRTTEELLDEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX0</accession>
    <name>E8MXX0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560571.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21750"/>
    <dbReference type="EnsemblBacteria" id="BAJ64201">
        <property type="protein sequence ID" value="BAJ64201"/>
        <property type="gene ID" value="ANT_21750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21750"/>
    <dbReference type="HOGENOM" id="CLU_2663058_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="75" mass="8611" checksum="C57ADED26E3B951D" modified="2011-04-05" version="1">MKAVRENSTNPVRTPAFTPAHYASVYASDNADVKRQRLRQRLRQIEALQGVYFEGMAMIRPLRKKALFQGVFEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-06-17" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX4</accession>
    <name>E8MXX4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560575.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64205">
        <property type="protein sequence ID" value="BAJ64205"/>
        <property type="gene ID" value="ANT_21790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21790"/>
    <dbReference type="HOGENOM" id="CLU_2406926_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="92" mass="10942" checksum="8B9AC44F68982CA9" modified="2011-04-05" version="1">MKDTVKWRVYRIEDRSDLEAAMQLYQMKFGERPRRARVSEKAPEELLHLVREIPDLEIEVLRPILPRDVWLTHEEEQTVPQAQLSLFGEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY19</accession>
    <name>E8MY19_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560619.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64250">
        <property type="protein sequence ID" value="BAJ64250"/>
        <property type="gene ID" value="ANT_22240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22240"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_13_1_0"/>
    <dbReference type="OMA" id="ALADCEM"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="24"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="194" mass="22275" checksum="FC170754818C3FE2" modified="2011-04-05" version="1">MSTTVTPTLRQRAVQVAREVLKHNPIYLDTETTGLSAQDEIIEISIVNDNGEVVYESLVRPTRPIPPDAIAVHGISNEDVQKARPWHIVWQEVRPILLNAGVVVIYNEEFDLRMMQQSHARLGLPWRDRFRTFDLMKLYAEYYGEWDPKRRAYRYHSLDAAGKHCGITLPNAHRATADTLLTRALLHFMAGVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC3</accession>
    <name>E8MYC3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00340"/>
    <dbReference type="EnsemblBacteria" id="BAJ62068">
        <property type="protein sequence ID" value="BAJ62068"/>
        <property type="gene ID" value="ANT_00340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00340"/>
    <dbReference type="HOGENOM" id="CLU_2434452_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="90" mass="10178" checksum="CC7A11C17C34AF6E" modified="2011-04-05" version="1">MCYTLTMQAYRAYWHAWAQTLQRWGLNEFAAALLEGAAPLSILMGQVITLSQPLLGAWVSTEKLEALAHLCEDDEERIAFASFLREENTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYH7</accession>
    <name>E8MYH7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_00880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558520.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00880"/>
    <dbReference type="EnsemblBacteria" id="BAJ62122">
        <property type="protein sequence ID" value="BAJ62122"/>
        <property type="gene ID" value="ANT_00880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00880"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_0"/>
    <dbReference type="OMA" id="AQADKMR"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="325"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="249"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="359"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="630" mass="71331" checksum="9F833C7726BD2F9A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ4</accession>
    <name>E8MYJ4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N_BRCA1_IG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_23040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23040"/>
    <dbReference type="EnsemblBacteria" id="BAJ64330">
        <property type="protein sequence ID" value="BAJ64330"/>
        <property type="gene ID" value="ANT_23040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23040"/>
    <dbReference type="HOGENOM" id="CLU_1197786_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="N_BRCA1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228532" description="N_BRCA1_IG domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="N_BRCA1_IG" evidence="3">
        <location>
            <begin position="134"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="231" mass="24440" checksum="97457D79114D86FB" modified="2011-04-05" version="1">MEDVRMLKKQIFAGIAVLLLATAGLVACQQATPAAPTLDANAVYTQAAQTVAAGIAQTEAAKPSPTPLPPTFTPTPTMIQPTATPELSGTPAAGTPQPSPTGAVGLTPLPTNTLAAPPAQTTGDKAEWVSQSPTDGTQIKKGEKFLVKYVLKNIGTTTWSTKYTFRYYAGDKMGSPNDLNLTKEVKPKDTVEIVFELTAPDKTGKTNTIWVLTNDQGINFYSVFLSIEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ7</accession>
    <name>E8MYQ7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560759.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64393">
        <property type="protein sequence ID" value="BAJ64393"/>
        <property type="gene ID" value="ANT_23670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23670"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2696464_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="73" mass="8221" checksum="2499B718BD6ABC6F" modified="2011-04-05" version="1">MSRAVNLLLGFLTGAVMGAALGLLLAPTSGRQLREEAREYVEEMKREVEEAAQKRREELELQLAHLRGEIRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYZ0</accession>
    <name>E8MYZ0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00990"/>
    <dbReference type="EnsemblBacteria" id="BAJ62133">
        <property type="protein sequence ID" value="BAJ62133"/>
        <property type="gene ID" value="ANT_00990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00990"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_0_0"/>
    <dbReference type="OMA" id="MVNTDAV"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="28532" checksum="A863BA85FE3F277C" modified="2011-04-05" version="1">MFAGQATVSAPFLSIILPAHNEEHRLPPALESLHAFLSAQSFSFEVVVVENGSTDRTREVLAEYAARFPYLVPLTDERRGKGLAVQRGMLTARGQYRMFCDVDFSMPVEQISRFIPPALPGVEIAIASREAPGAVRYGEPVVRHIIGRGFNTLVRWVALPGLQDTQCGFKCFRGDIAERIFPLQTLHGWTFDVEVLFIARRLGYRVVEVPIPWYYNAESKIRVLRDSYAMFADLIRIRLNARRGMYDGAPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ23</accession>
    <name>E8MZ23_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">POU-specific domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_01320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558564.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01320"/>
    <dbReference type="EnsemblBacteria" id="BAJ62166">
        <property type="protein sequence ID" value="BAJ62166"/>
        <property type="gene ID" value="ANT_01320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01320"/>
    <dbReference type="eggNOG" id="COG3688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1617753_0_0_0"/>
    <dbReference type="OMA" id="HSEVEEW"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POU-specific" evidence="3">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="158" mass="17778" checksum="44572115AF02DEC0" modified="2011-04-05" version="1">MIYLIDGHNLIPHLPGLNLAQIEDENRLIALLQNFARQRRCTVEVFFDKAPPGRAGKHRARNITVHWVEEGKTADSAIIAVLQRLGKRAVEVTVVTSDRQILAEARTRRAKTLSSDEFARQLLSARTPAASAGAEKPDKPSEDEVEEFLNLFRKKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ28</accession>
    <name>E8MZ28_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558569.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01370"/>
    <dbReference type="EnsemblBacteria" id="BAJ62171">
        <property type="protein sequence ID" value="BAJ62171"/>
        <property type="gene ID" value="ANT_01370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01370"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028666_0_0_0"/>
    <dbReference type="OMA" id="APASWWF"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225337" evidence="1">
        <location>
            <begin position="21"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="431"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="640" mass="71621" checksum="A805E5552C730662" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ38</accession>
    <name>E8MZ38_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_01470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558579.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01470"/>
    <dbReference type="EnsemblBacteria" id="BAJ62181">
        <property type="protein sequence ID" value="BAJ62181"/>
        <property type="gene ID" value="ANT_01470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01470"/>
    <dbReference type="eggNOG" id="COG3714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079086_1_0_0"/>
    <dbReference type="OMA" id="ARAAWFH"/>
    <dbReference type="OrthoDB" id="1768508at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="219" mass="24119" checksum="C04B0A0F66961B06" modified="2011-04-05" version="1">MNTWLLVLTFAACVLEWVAVLQKSRWHDFTKPLPMILLILWYSLSGGWTGQGVWFGLGLAASLLGDLLLLRERTFLPGMGAFFLAHVFYITGLWHGAPPQMGLAVLFLAVVAVALGWLAWQARGEAWRRLKQAGMALPVTAYALILSAMTFSALLTLARPDWNPQGALLLALGAVLFFLSDAILAWDRFLRPLRAPEVLMIPYLLGQVGIAVGAWLTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ45</accession>
    <name>E8MZ45_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558586.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01540"/>
    <dbReference type="EnsemblBacteria" id="BAJ62188">
        <property type="protein sequence ID" value="BAJ62188"/>
        <property type="gene ID" value="ANT_01540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01540"/>
    <dbReference type="HOGENOM" id="CLU_1472319_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225173" evidence="1">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="183" mass="19329" checksum="2ED204A75729E2DD" modified="2011-04-05" version="1">MRKLTLIVLVAFLALSACASPVPSSTPVPTLGETRDVTGGGFSFQIPPDYSASVEGGRVDLSDKQGSLLLHLYGEPADVGETSLEKIVDSIVSEAMLRGNGVYEKSAVYTVTIAGVKGNGYDLIGTYFGAPFEGQAVIVPRKSGGFFFGMGLALGQGEEGRWQKEGKAVFQAMLQTVQFTDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ57</accession>
    <name>E8MZ57_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdxT</name>
        <name evidence="7" type="ordered locus">ANT_01660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558598.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01660"/>
    <dbReference type="MEROPS" id="C26.A32"/>
    <dbReference type="EnsemblBacteria" id="BAJ62200">
        <property type="protein sequence ID" value="BAJ62200"/>
        <property type="gene ID" value="ANT_01660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01660"/>
    <dbReference type="eggNOG" id="COG0311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069674_2_0_0"/>
    <dbReference type="OMA" id="VFIRAPI"/>
    <dbReference type="OrthoDB" id="1628378at2"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="191" mass="21174" checksum="6B2420A0DE198B31" modified="2011-04-05" version="1">MKLGVLALQGDFIEHQTMLERLGVEVQQVRLPSHLEGLAGLIIPGGESTTIGKLAVDFGLLEPLREFGRQRAIWGTCAGAIFLSKDVGRPQPLLELMDITVQRNAFGRQVDSFETDLDVSFMGKEYNGRPFHAVFIRAPIIEKVYGNARALITLGDGRIVAAQQGKLLATSFHPELTGDDRFHRYFVELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ79</accession>
    <name>E8MZ79_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_01880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558620.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01880"/>
    <dbReference type="EnsemblBacteria" id="BAJ62222">
        <property type="protein sequence ID" value="BAJ62222"/>
        <property type="gene ID" value="ANT_01880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01880"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_0_0_0"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="305" mass="33127" checksum="73C084D626BF388E" modified="2011-04-05" version="1">MSTESEEDFFRSLRVAIVGLGLMGGSLALALRGRVRAVLGVDTHAPTRQQALERGAVDTVSADPADLLPQADVVVLATPVQSILHLLERLPDLHPGRAVVLDVGSTKREILAAMVHLPQRFDPLGGHPMCGKEHSSFEHAEADLYHGAAFALCPLERTSAHARQVAESLVQAVGARPLWLDAETHDRWVAATSHLPYLLASALASSVPPQAAPLAGPGYRSTSRLASQPADLMLEVLASNRDYLLTTLRRAQLRLDLLAQALEAEDWQSLRALLAESAHQRESLLNLHGEKPHESHREPRRTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ89</accession>
    <name>E8MZ89_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558630.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01980"/>
    <dbReference type="EnsemblBacteria" id="BAJ62232">
        <property type="protein sequence ID" value="BAJ62232"/>
        <property type="gene ID" value="ANT_01980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01980"/>
    <dbReference type="HOGENOM" id="CLU_2448205_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="89" mass="10416" checksum="A240D5CF1EACDE0D" modified="2011-04-05" version="1">MEGFLIILALALGIYFVCKVDQDRDSQQKANRFFMEEEEEKQRREEIIRSGIAYNAWNHMRNHDGNPYNDSVGSAFTPGTDAWKANRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD9</accession>
    <name>E8MZD9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_4-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560842.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64487">
        <property type="protein sequence ID" value="BAJ64487"/>
        <property type="gene ID" value="ANT_24610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24610"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646625_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="24"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="424" mass="47972" checksum="8881A897C4BC9179" modified="2011-04-05" version="1">MGEDSSRYRVLVLTRFFPPYGTAGGSIRIVKWMRYLAPEGWHFTVLTQDPQKPINRSPDSCENLLGEIPAGTEVVRVPAPFTLADPVGLGWRGLLASTLWGMRTLWVALKKAPKVDLILAVALPFTTAWMGALLSRLKGKPLVLDLKDDFVGNPIQKFKSPMRRFLEKEAEVWVFRTCRAVSVVTPESLEVYRRRYPQFAECIHYIPNGSDLEEIQQMKDVPQPPIDDHVFLILSTAGRYESGYRDAGPFLQSLALFLNKMPEAHPHVQAVFLGNALGKEYQPLLEQHNLSGVVKNFPAVSRRELVGWLRRANLYFLAQPLGNTTAIAGTLYEYWAAGQAPILLFAEPGSAQRLVDERKLGRCFGFHQIQDASDFMLQMYEVFQRGERVRIPQEGLEQYDRRKLAGEFGALLDKVIQVSQRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK4</accession>
    <name>E8MZK4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_25260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64552">
        <property type="protein sequence ID" value="BAJ64552"/>
        <property type="gene ID" value="ANT_25260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25260"/>
    <dbReference type="eggNOG" id="COG1620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021628_0_0_0"/>
    <dbReference type="OMA" id="LFVYKMP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="554" mass="59611" checksum="3E71B6204E980ED9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK5</accession>
    <name>E8MZK5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_25270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560908.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25270"/>
    <dbReference type="EnsemblBacteria" id="BAJ64553">
        <property type="protein sequence ID" value="BAJ64553"/>
        <property type="gene ID" value="ANT_25270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25270"/>
    <dbReference type="eggNOG" id="COG1313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_0"/>
    <dbReference type="OMA" id="GGEPTPN"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="80"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="303" mass="34152" checksum="B1D64E66ABA6BB09" modified="2011-04-05" version="1">MTAFVPAYWKLLESGELQERVQRAYAGLESCEWCPRRCRVNRLAGKRGVCHTGEQARVASYGPHYGEERPLSGWKGSGTVFFNRCNLRCVFCQNHDISQTDEGMEVTPEQLAQIFLRLQAMGCHNINLVSPSHVVPQILAGVFLAAQAGLRLPLVYNTGGYDALEALQLLDGVVDIYMPDMKYADAAVAKQYSGVKDYPQVNRAAVREMHRQVGDLKINAQGLAERGLLVRHLVLPHRLAGTREIMKFLAEEISPNTYVNVMGQYRPEFLAERFPLLNRRVTLEEVYQAREEARCAGLNRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM5</accession>
    <name>E8MZM5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560928.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25470"/>
    <dbReference type="EnsemblBacteria" id="BAJ64573">
        <property type="protein sequence ID" value="BAJ64573"/>
        <property type="gene ID" value="ANT_25470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25470"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095977_0_0_0"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="186" mass="21102" checksum="924B5A18641A988B" modified="2011-04-05" version="1">MLTLRFDGLYRPLTQEGGTAPHAGVMCYGWVISRNGKPIARGHGGYMRRNDASSNIAEYLGLIEGLEALLDMGAEDEAVEIIGDARSVIDQMVGRAAVNSASTRPLYRRAQRLASRFRRLLWTWTPRRKNHAADQLTRRAMKQIRANTRQYRETIHALEMEQHPDRSRTLFPLLNLRVYQPGGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV7</accession>
    <name>E8MZV7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sodium/calcium exchanger membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_02580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558689.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62292">
        <property type="protein sequence ID" value="BAJ62292"/>
        <property type="gene ID" value="ANT_02580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02580"/>
    <dbReference type="eggNOG" id="COG0530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007948_2_1_0"/>
    <dbReference type="OMA" id="NIFNMVI"/>
    <dbReference type="OrthoDB" id="804531at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="174"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="327" mass="34648" checksum="2B0EB146B2553334" modified="2011-04-05" version="1">MMWIQFVITSAVIVLAAIKLAEYGDVIALRTRLGGLFIGTILIAAATSLPEVLTTLSAVRQAFPNLAAGNLLGSNTFNMFLLAVLDVLARNERVLRKVALKHALSGSLAIFSIGLVLFFMIADLPLKIGWVGVDSLLIMLAYFAAMYLIQASNVGDVPGQIEIPEGTPSLAVALLGFGIAAGALIYVTPFMVSASAEIAEVTGLGTTFVGSTLVAAVTSLPEMVTTLAAMRLGAYDMAIGNLFGSNLFNMFALGLTDVFYTPGRFLAVIDPSFLLVGMLGLLMTGMGLIGNLARLRRRIWFIEADALALAVLYLGGMYLLYLRGISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW2</accession>
    <name>E8MZW2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_02630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02630"/>
    <dbReference type="EnsemblBacteria" id="BAJ62297">
        <property type="protein sequence ID" value="BAJ62297"/>
        <property type="gene ID" value="ANT_02630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02630"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_5_1_0"/>
    <dbReference type="OMA" id="FKKKALC"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="34"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="32302" checksum="4FA04AD61B7F2AEC" modified="2011-04-05" version="1">MRRALWFFAVIILILFLSSCASRTVQGETLSTEPSYYIQNKGSDTIVNLALRWAEAYQQAHPEVRISVTGGGSGTGIAALIDGTVDIANASRAMKKEEIEAARAKGIEPVEHVIARDAIAVIVNPSNPVSQLTLEQISLIYQGKINNWREVGGEDRPIVRLSRETNSGTHVYFLEAVVRLGQKDNKALFSPDTLLLPSSEGIITEVRDNPNAIGYDGLGYVTPEVKVLAVAKTADDPYILPSVETVNSGAYPISRDLYMYTQKEVNAAVQAYLDWLLSPEAQKIVLELGFVPVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX4</accession>
    <name>E8MZX4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_02750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558706.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02750"/>
    <dbReference type="EnsemblBacteria" id="BAJ62309">
        <property type="protein sequence ID" value="BAJ62309"/>
        <property type="gene ID" value="ANT_02750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02750"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1033057_0_0_0"/>
    <dbReference type="OrthoDB" id="1719840at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="3">
        <location>
            <begin position="84"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="269" mass="28906" checksum="0660074169DF59B7" modified="2011-04-05" version="1">MKSKPFTFAQIAVLVMLALLTLGGLGWMLHLLLTPPPAEVRLSMTLQPAQMLTPTLPPASSTAESSPSPTPTPSQASCLPANAASLSARVRHVLDGITLEVEINGETRQVRYLGVELPQQSELADALNRQWTENQTVQLIADPAVPPQSEPALYYVLAGGVFVNQALIREGAALPALYPPGIACIEAFLQEEAQARAEQKGVWKDLLAHLPTPAVSIGLTPPACDCNRRYTCADFATRREAQACFDACGDYRNTTLDPDHNGLACEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY9</accession>
    <name>E8MZY9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribF</name>
        <name evidence="13" type="ordered locus">ANT_02900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558721.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02900"/>
    <dbReference type="EnsemblBacteria" id="BAJ62324">
        <property type="protein sequence ID" value="BAJ62324"/>
        <property type="gene ID" value="ANT_02900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02900"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_0_0"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="180"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ62324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="33996" checksum="55E857D12E4A5DDE" modified="2011-04-05" version="1">MKHIRSLDEFPRGRTYLTVGSFDGVHRGHQGLLSALAQAAHQAGAQSAVVTFFPHPVAVLRGLSQPYYLTSPEERARLMGECGIDVVLTLPFTRELAALSAREFVTLLREKAGMESLWVGYDFALGRNREGNVPALQRLGEELGFTVHVLPPVALEDIPVSSSLIRAALEQGDVVSAARMLGRPYTIEGAVVHGDARGRTLNIPTINISFWAEQRLPAFGVYACRVEVEGLVLDAVANIGIRPTFANPNGEVRLEAHLLDFSGDLYDRTVRLQFVAFLRPERRFESVEALVAQIQQDIQHAREVLTHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N093</accession>
    <name>E8N093_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_26160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560996.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26160"/>
    <dbReference type="EnsemblBacteria" id="BAJ64642">
        <property type="protein sequence ID" value="BAJ64642"/>
        <property type="gene ID" value="ANT_26160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26160"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_3_0"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="206"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="392" mass="44019" checksum="41A472A91303BEBB" modified="2011-04-05" version="1">MKILIPEISNPPETFLQRLILGLAEQGVEVFLATEQIKKGSLLNVHEKIRTVWKPSWNVPLGRKAFNITRILLLSLKKGRIKDFLKALRANSLREWYRVFPVLDKPFDLWYFPWILSAKDYLPYLREHGIPFVVSCRGSMVNVDPFTHRGEGTQGILREIFSAASVVHCVSRDILKTAEPLGLNPNKAVVIHPAVDVSFFSPPQVLHKDSTIHITTTGALIWRKGYEYALQAIAFLKQRGYSVHYHILGEGPERQRLLYTVDDLDLCSTVTLHGKCSPEEVRRVLQKSHIFLFSSLSEGLPNAVLEAMACGLPVVTSNCGGVSEAVTDGVEGWIVPVRDPEALAGAVERLILDKEMRLTMGEAARRRVVQSFNLSDQIPAFRTLFERVSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N096</accession>
    <name>E8N096_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560999.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64645">
        <property type="protein sequence ID" value="BAJ64645"/>
        <property type="gene ID" value="ANT_26190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26190"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771081_0_0_0"/>
    <dbReference type="OrthoDB" id="1271185at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="352" mass="41448" checksum="046008FDF41075A5" modified="2011-04-05" version="1">MKVYADYSHYHGKNRYFLNNIHKALWNDRSPEERDQVYGNWWRGFESVPNVSDADVVLLTNTWNYYLDHGLISQAEEEIRLAQQHKKKIVVFCGGDAPANLIQPNVILFEMGGYRSVQGLAYHSGIPFFLRDLLTIYCGGQLQFRTKPEVPVLGFCGQSDSSFLFNIFRKTRNLYQKLLYRLGLRKWQPPPFETVSFRRRVLHQFEGSGLVKTNFRLRRQYHAGNNRDKSDFSPQRLDFIQNILNSDYTVCIRGGGNFSIRFYETLSLGKIPIFVDTDCLLPFPDKIPYQQIFPWINVEDLPRAAEIVADFHSRLSNQDFIHLQRMCRQLWEEHFTPNGFYKDFQEKVYEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F6</accession>
    <name>E8N0F6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_26790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561057.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64705">
        <property type="protein sequence ID" value="BAJ64705"/>
        <property type="gene ID" value="ANT_26790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26790"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_4_1_0"/>
    <dbReference type="OMA" id="YEKRDNI"/>
    <dbReference type="OrthoDB" id="1508841at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="47"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="201" mass="23007" checksum="5527C96937C4EBAF" modified="2011-04-05" version="1">MEWKTSLDEAFLERLEEFPALRAFYQVQHLKHLYRQGWLKAGVPRERCETVADHIFGVTMLCWLLIEAGSAPQVNPERALRMALIHELGEIYTGDIIPSDAIPAEEKHARERQSLERVLENLPGAEDIRALWEEFEAGTTPEARLVHQADRLEMALQAVTYVREGVLKDPSSFFRSARQAVNDPALQEWLEIAKNFGKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G7</accession>
    <name>E8N0G7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561068.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64716">
        <property type="protein sequence ID" value="BAJ64716"/>
        <property type="gene ID" value="ANT_26900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26900"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374559_0_0_0"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="741" mass="81402" checksum="3CD6AA150F3B46E9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R3</accession>
    <name>E8N0R3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558854.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62458">
        <property type="protein sequence ID" value="BAJ62458"/>
        <property type="gene ID" value="ANT_04240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04240"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030024_5_2_0"/>
    <dbReference type="OMA" id="AYPFGLW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225197" description="NodB homology domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="152"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="34139" checksum="720C9792CE17DAB2" modified="2011-04-05" version="1">MRRILLGLLVMALAGAVGCATTGYAAPLDEAGQTQVAQKVETMLATANSFPANTPSPGSSATLPPTFTASPTMTLTPTLTPSPTWKNVFAGEVYAPILLYHRVVEGQENNRYAVSPTAFEEQMRFLAENGYTTITPAYLARVILVGGQLPERPVLITFDDGYADTYTNAFPIMEKYGLKGALYVVTSTVGVGEFITIEQLRDLAAHGWEIGSHTVRHVDLVKNPDQVEKELEDSRQTLQDWLGMPVLTMAYPYGKANEYVQTKTRLAGFRAGLRIGIFNRHTPDSLFELSRREVRAEYTLEQFIELLSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N123</accession>
    <name>E8N123_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558964.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05340"/>
    <dbReference type="EnsemblBacteria" id="BAJ62568">
        <property type="protein sequence ID" value="BAJ62568"/>
        <property type="gene ID" value="ANT_05340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05340"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385370_0_0_0"/>
    <dbReference type="OrthoDB" id="324825at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="844" mass="84857" checksum="D3B03565EDD30E41" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N148</accession>
    <name>E8N148_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561139.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64791">
        <property type="protein sequence ID" value="BAJ64791"/>
        <property type="gene ID" value="ANT_27650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27650"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_6_1_0"/>
    <dbReference type="OMA" id="HILSVIH"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="116" mass="12520" checksum="A0961632D1DB141C" modified="2011-04-05" version="1">MISSSLSQEITALHADICSALADPARILILYALNEKPSNVSTLAEELGITQSAASRHLNVLRDRGLVISQRDGQSVVNMLADPRVIQALDLLRAVLTSKLKNQAALAETMEPSEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N178</accession>
    <name>E8N178_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative L-threonine dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_27950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561168.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27950"/>
    <dbReference type="EnsemblBacteria" id="BAJ64821">
        <property type="protein sequence ID" value="BAJ64821"/>
        <property type="gene ID" value="ANT_27950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27950"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="OMA" id="GVFHNTP"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="169"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="331" mass="35690" checksum="82342C22E636231B" modified="2011-04-05" version="1">MKAVRIVQPHQVEIVDLPIPTPGEKEILIRVEASGICGTDLHILRGEYMGNYPVIPGHEFSGTVVETGAGVTRFRVGDRVAVEPNLSCDACEECLNNRQNFCRNWQAVGVTLPGGMAEYVVVPEKAAFAVGDLPAEQAAFMEPLSCVLHGMENLSPRMGDRLLIIGAGPIGIQLMRVARLQGAAHITMVERNPARLMFAAEAGADRALSSLDDLSPDSFDAVIDATGVPAVLARTLDYVRSGGKVLWFGVPRSDATMALEPFKIFRKGLTVMGSFTSKRNSYQAVALLQSGALRVDDLISHRLPLADFLRGCELLEQGAEGVKKVMILPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N182</accession>
    <name>E8N182_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_27990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27990"/>
    <dbReference type="EnsemblBacteria" id="BAJ64825">
        <property type="protein sequence ID" value="BAJ64825"/>
        <property type="gene ID" value="ANT_27990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27990"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462842_0_0_0"/>
    <dbReference type="OMA" id="REEFLHV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="368"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="589" mass="64293" checksum="7E5BDA955F88746A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A2</accession>
    <name>E8N1A2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561191.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64845">
        <property type="protein sequence ID" value="BAJ64845"/>
        <property type="gene ID" value="ANT_28190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28190"/>
    <dbReference type="eggNOG" id="COG1322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705240_0_0_0"/>
    <dbReference type="OrthoDB" id="1309809at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="391" mass="43093" checksum="9FBF81EA790B3D5E" modified="2011-04-05" version="1">MENDAVSTLTFLSAVSLLLLCLLIPIVGFLLFQMRKLLKAATTPPAPSPEMAVLKEKISQVETLIPSVSALQSEVRGLSERISSVENTQTSTQQGIGSLSTQALSALAELKTLTGGIAEAASRLRADLSQTQNHLSELQAFVRARQEEERQVAESIRRLETIIAGTQSKGKAGENIVEVVFSKFPPEWQERNLKVNGKTVEFALRLPNQRFLPIDSKWAATSLVEEFARETDEKQLQRLRGEIEKEVAKKLKEVTQYIDPHLTVNFGVAVVPDAVYDLCGRVHAEAFKMNVVLVSYSLFVPYLLLVYQVTLKSAQTVNVEALSHHLENIQKSVGKMQEEVNGRLSKGLTLLVNSRDEMKSLLGSISDHIASLKILEYSALPEGGESTANLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F7</accession>
    <name>E8N1F7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561245.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64900">
        <property type="protein sequence ID" value="BAJ64900"/>
        <property type="gene ID" value="ANT_28740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28740"/>
    <dbReference type="HOGENOM" id="CLU_1040679_0_0_0"/>
    <dbReference type="OrthoDB" id="2124102at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="267" mass="28521" checksum="6E48C368C18CDA52" modified="2011-04-05" version="1">MNSNSRAMSAQLRSAISRANPSVVFLVMILGALLAFEIFNYSTTDHALRDLLGDLKFGGMYWSTILAIAFCGIDFAGIARLFTPEQGENEPREIWYLFGAWLLAATMNAILTWWGVSMAITNHKVQSAAVINPKTLATVVPVFVAIMVWVIRVLIIGTLSVALDRVIHGETSRSRSWRNTAATPAGLPTPAPLPTAPSFAPRPAPTPALNRSTTASRTSSGASFGASAPSEPAPIPEPTYHSLSMSGRTTSATPVGSRPASTPTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H9</accession>
    <name>E8N1H9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558980.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62584">
        <property type="protein sequence ID" value="BAJ62584"/>
        <property type="gene ID" value="ANT_05500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05500"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1406194_0_0_0"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="54"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="193" mass="21854" checksum="C5B0B9064E266C8E" modified="2011-04-05" version="1">MTEKSKIFTSMLMGTIFLLFIAIAGLFIRVNQLQNQILVLMEYFPVDAGQNSGLSIDTNAPDFTLPNTDGKYFSLHDFLGQKILLGFSSIDCPYCKKMYPELRSFSKKSSNLQIVLISRGTLKENQELVQEQQFNFPILTLEQGNSEIGKNFQVPGTPFFYVIDEVGKICSKGFANTEEHLEELIRKCNQNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1J6</accession>
    <name>E8N1J6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558996.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05670"/>
    <dbReference type="EnsemblBacteria" id="BAJ62601">
        <property type="protein sequence ID" value="BAJ62601"/>
        <property type="gene ID" value="ANT_05670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05670"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036192_0_0_0"/>
    <dbReference type="OMA" id="TGDRWFT"/>
    <dbReference type="OrthoDB" id="1636709at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009499">
        <property type="entry name" value="DUF1116"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024033">
        <property type="entry name" value="Uncharacterised_dom_sf_YlbE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06545">
        <property type="entry name" value="DUF1116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="414" mass="44340" checksum="3499B734A0D803BB" modified="2011-04-05" version="1">MVDIEKANQQAVERMMDARPVVVGVAPAIDVIPGMHKDLLLHAGPPVTWERMAGPMKGAMVGALIWEGRAKNWDEAEALLSSGKIKFEPCHEHSAVGPMAGVISPSMMVYIVENKTHGNRAYSGLNEGRGKVLRMGAYSEDVLARLTWMNEVLGPVSHKALEAMGGLDLRTLLGKALHMGDDGHNRLDAASILYTTQMAPWIAKVAKDSDTAAEVIRFLGENALSILNQVMAGCKTMADAAHGIEGSTIVTVMARNGTDFGIRVSGLGDRWFTGPAGKVKALYFPGFTEKDANPDIGDSTITETAGIGGFAMAAAPAIVTFISGTPQDAIKTTLDMYEITYTEHKHFTIPYLNFRGTPTGIDIRKVIEKNVLPRVNTGVAHKDPGIGQVGAGVVTPPQNIFEDALVAFAEKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N7</accession>
    <name>E8N1N7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559037.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62642">
        <property type="protein sequence ID" value="BAJ62642"/>
        <property type="gene ID" value="ANT_06080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06080"/>
    <dbReference type="eggNOG" id="COG2141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_7_0_0"/>
    <dbReference type="OMA" id="WNAVEYE"/>
    <dbReference type="OrthoDB" id="1434838at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="294" mass="31849" checksum="D3892505E03AB52C" modified="2011-04-05" version="1">MHFGVILPNYGAGSGRLAVLDTALLAEALGFPSVWTTDHLALPVGDAERFTPLLEALTTLAYLAGSTARVKLGVSALVLPQRNPLEVAREVATLDVLSGGRVVLAAGIGWSQGEYANLGYSFTNRGKRMEEALQVLRTCWRGNRVVSYQGRYYRFEKVDFAPAPIQAGGPPLWVAGNSPAALRRALRLADGWHPVGLSPDVLAGQLAKVRPLLANRPFTVAVRLSVAWGHETAEGGALAGSPEQILEMLRLYQSSGATAFLLHFLAENQSERERVMRAFAREILPHFPRDVEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R2</accession>
    <name>E8N1R2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559062.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62667">
        <property type="protein sequence ID" value="BAJ62667"/>
        <property type="gene ID" value="ANT_06330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06330"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975368_0_0_0"/>
    <dbReference type="OMA" id="WRICIDI"/>
    <dbReference type="OrthoDB" id="1495490at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="62"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="32903" checksum="0705300F25C45952" modified="2011-04-05" version="1">MSGEPVRQQVRSFYDQIGWQKEADGLYQNARYEDLRPVSAEYIHRCHLRVKRHLAPEGRYLLDAGSGPVQYPEYLTYSEGYQYRVCADLSIVALQEARRRLGEHALCVVADVAHLPFAPEAFDGVVSLHTLHHLPLEEQPNAYNELFRVLKSGKKGVVVNGWTDSPLMRRWAPLVALAERLGTWVARLRSRAVAAEKKTSVSQPTGTFVRKLDAAWLREHLQGKIPYEIYVWRSVSVRWLRALVHSITGGKVWLKLLYWLEERNPRWYGENGQYPLIVISKERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S4</accession>
    <name>E8N1S4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559074.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62679">
        <property type="protein sequence ID" value="BAJ62679"/>
        <property type="gene ID" value="ANT_06450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06450"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_0"/>
    <dbReference type="OMA" id="GILDNQP"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="29491" checksum="B102033D5B6714FD" modified="2011-04-05" version="1">MSDIFEKFSLKGRAAIVTGGAGLLGMEFCRTLGQAGASVLVADLNAEAAYRTAESLRAEGLTALHAVVDVTQPESVQAMVEACVDEFGSLDVIVNSAAMDPKFDASQAGKHTNAFEDYPLEMWKQALDVNLTGVFLCCQAAARQMVAQGGRGSIINICSTYGLVPPDQRIYEKPGQPKQFKPAFYTATKAGVLGLTKYIAAYYAGTQIRANCLTPGGVYNNHDETFVRNYSYRTIMGRMAQRDEMNGALLFLASDASSYMTGGNIIVDGGWTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1U0</accession>
    <name>E8N1U0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative two-component response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559090.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06610"/>
    <dbReference type="EnsemblBacteria" id="BAJ62695">
        <property type="protein sequence ID" value="BAJ62695"/>
        <property type="gene ID" value="ANT_06610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06610"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_0"/>
    <dbReference type="OMA" id="IIFIDIM"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="126" mass="13501" checksum="EE85BDBB06C01001" modified="2011-04-05" version="1">MAKILIAEDEPDIRDLVKFTLGFAGHEVIAVGNGEEAVEAARAEKPDLILMDVRMPRMTGYEACAAMKADPSIAHIPVVFLSAKGQESEIQTGLSVGASEYLLKPFAPMDLTQRVAELLAKFAGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1W7</accession>
    <name>E8N1W7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561259.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28880"/>
    <dbReference type="REBASE" id="32157">
        <property type="entry name" value="AthUNI1ORF28870P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64914">
        <property type="protein sequence ID" value="BAJ64914"/>
        <property type="gene ID" value="ANT_28880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28880"/>
    <dbReference type="eggNOG" id="ENOG502Z936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084445_0_0_0"/>
    <dbReference type="OMA" id="HASISCK"/>
    <dbReference type="OrthoDB" id="1390443at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015105">
        <property type="entry name" value="NgoMIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037083">
        <property type="entry name" value="NgoMIV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09015">
        <property type="entry name" value="NgoMIV_restric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="32349" checksum="642E423310819BB9" modified="2011-04-05" version="1">MWLEELRQEYHQRICREIVRIQQGESAYPNFADKSSKASREIAWRILEKIGYQTSQEQSLPGQTAGGRFEDVTRDFLEKAFQELQHIRPGKWLYKTGMNISLFDQYEHLARLQKLTIKNSDLSSIFGTEYLITPDITVSREPLNDEEINRSMTIVEDSRLAGLTPLRKTNSSVPILHASISCKWTLRSDRSQNARAEALNLIRQRKGNTPHIVVVVAEPLPTRIASLALGTGDIDCVYHFALPELQQAILEIHNEDQHDMLQTLIEGRRLRDISDLPFDLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X2</accession>
    <name>E8N1X2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosidase</fullName>
            <ecNumber evidence="3">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561264.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64919">
        <property type="protein sequence ID" value="BAJ64919"/>
        <property type="gene ID" value="ANT_28930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28930"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_1_0"/>
    <dbReference type="OMA" id="DYVINHS"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="18"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="541" mass="61858" checksum="4F483222B252237F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N247</accession>
    <name>E8N247_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_29680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29680"/>
    <dbReference type="EnsemblBacteria" id="BAJ64994">
        <property type="protein sequence ID" value="BAJ64994"/>
        <property type="gene ID" value="ANT_29680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29680"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="OMA" id="FNTLQMG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="53"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="369"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="609" mass="66403" checksum="0D734F7C52727FB0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N262</accession>
    <name>E8N262_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribonucleoside hydrolase</fullName>
            <ecNumber evidence="4">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_29830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561353.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29830"/>
    <dbReference type="EnsemblBacteria" id="BAJ65009">
        <property type="protein sequence ID" value="BAJ65009"/>
        <property type="gene ID" value="ANT_29830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29830"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885059_0_0_0"/>
    <dbReference type="OrthoDB" id="1763387at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="6"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="33783" checksum="303CFA1D4583A6DF" modified="2011-04-05" version="1">MKQKIHLDTDLGGDIDDLCALAYCLRHPGAELVAVTTVAEHSGKRAGYVRHALRLAGREDIPVAAGIEARWQGYRFEQPLPDEQDYWRGEIPPYPTPPEQALDLLEESIRHGAHIVAIGAYTHLTMLEARQPGILAKAHLTVMGGFVHPPREGYPAWDFTADWNVQVDASSARVVFERGNPTLVPLAVTAETALRHVHLPGLERAGALGECIAHQARVFAHTEQLAERYLPDCPALPADFINFQHDPLACAAALDWSGLTFADLRLRVELEQGWVRLVEDPRGKVFRVAVGVDGEAFSAHWLETVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N271</accession>
    <name>E8N271_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative formate dehydrogenase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">ANT_29920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561362.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29920"/>
    <dbReference type="EnsemblBacteria" id="BAJ65018">
        <property type="protein sequence ID" value="BAJ65018"/>
        <property type="gene ID" value="ANT_29920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29920"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_0"/>
    <dbReference type="OMA" id="DGPPCCY"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02790">
        <property type="entry name" value="MopB_CT_Formate-Dh_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041925">
        <property type="entry name" value="CT_Formate-Dh_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="218"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ65018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="927" mass="101715" checksum="6619B390906E699F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N283</accession>
    <name>E8N283_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561371.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30040"/>
    <dbReference type="EnsemblBacteria" id="BAJ65030">
        <property type="protein sequence ID" value="BAJ65030"/>
        <property type="gene ID" value="ANT_30040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30040"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_0"/>
    <dbReference type="OMA" id="DNPMNME"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="128" mass="14235" checksum="211018CBB1DD1223" modified="2011-04-05" version="1">MSEPNRILVIEDNADNLELVRFLLEQAGFQIISAMDGLDGLEKARSLKPDLVLLDMSLPELDGWHLAKQLKESPETAHILIVALTAHTLPGDRRRALEAGCDGFISKPLNVARFASQIQEYLRNNSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C7</accession>
    <name>E8N2C7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_06990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559127.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06990"/>
    <dbReference type="EnsemblBacteria" id="BAJ62733">
        <property type="protein sequence ID" value="BAJ62733"/>
        <property type="gene ID" value="ANT_06990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06990"/>
    <dbReference type="eggNOG" id="COG2317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_0"/>
    <dbReference type="OMA" id="EFGHALY"/>
    <dbReference type="OrthoDB" id="239313at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="500" mass="57848" checksum="AFC696407447D97F" modified="2011-04-05" version="1">MEEKLAKLKTLLGEITDLTATAAILSWDQQTYMPPGGAEDRGSQLALLARLEHERWVSSEMGELLADLEKETAHLPADSFERALVRVTLRDYQKRTRVPAQWVSEFTEVTTLAQEAWVKARQQADFRPFQPHLERIVEMRREYSEFFKPYTHVYDPQLDDFEPGMKTAEVQAIFDEVRPRQVALLKAIQSRPQVDDSFLQQEFPEKAQWDFGVEVITRFGYDWQKGRQDKSAHPFTTSFGVGDVRITTRVDTRRLGTALFGTMHECGHALYDLGLDPAYHRTPLRHGASMAVHESQSRMWENLVGRSLPFWKFFYKRLQEYFPSQLGNVPLEAFYKAINKVEPSFIRVEADEATYNLHIMLRLELEIALLEGSLEVKDLPAAWNEKFQSYLGLTPPNDALGVLQDIHWSSGYFGYFPTYALGNLVSAQLWEKINKDIPDLEGQIEKGEFGALLSWLRENVHRWGRLYEPQDLVEKVTGSRITPQPYLRYLERKYGEIYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G0</accession>
    <name>E8N2G0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_07320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559159.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07320"/>
    <dbReference type="EnsemblBacteria" id="BAJ62766">
        <property type="protein sequence ID" value="BAJ62766"/>
        <property type="gene ID" value="ANT_07320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07320"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_1_0"/>
    <dbReference type="OMA" id="YDHERIT"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="248" mass="26679" checksum="B112918B90E88516" modified="2011-04-05" version="1">MLEALEKALDESTFLVSIQSANNEIGTIQPISEIVFMAHSHGVLVHTDAAQAVGKIAVDVNAWGVDLLSLSAHKMYGPKGVGALYVRGGIRKIPIRPLLEGGGQERGLRAGTSNVPGIVGLGKASEIACSEISSESLRLQTLRDELEKRLLENIPHLRINARFAPRFPNTSSLTFEEDADVLLLRLPQLMMSTSSACNTGAPEPSHVLQAIGLTRKQASSSIRISLGRLTTADDIHFVVHQFSSVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G6</accession>
    <name>E8N2G6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Divalent metal cation transporter MntH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">mntH</name>
        <name evidence="7" type="ordered locus">ANT_07380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">H(+)-stimulated, divalent metal cation uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07380"/>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2G8</accession>
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        <submittedName>
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        </lineage>
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        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
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                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ62774.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="529" mass="59585" checksum="5045FD831F838CA4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Putative 30S ribosomal protein S1</fullName>
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        <name evidence="3" type="primary">rpsA</name>
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        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
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    <dbReference type="KEGG" id="atm:ANT_30410"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="S1_domain"/>
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        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="entry name" value="SSF50249"/>
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        <property type="match status" value="4"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
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            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
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            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
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            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ65067.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="408" mass="45856" checksum="D0A9C3CEFA99F7C8" modified="2011-04-05" version="1">MDEKDTQLEQGMPQQTQDNAENHDNMASLLEKEGLGLDLPKEGEIRTGVIASITPQQILVSVGTKSEGVISGRELEAIPPEIRETLQVNQKILVYVVRPEDSNGNIVLSYMKAREESDWQKAEQMRETKEVYHSKITGYNKGGLIVPVHGLRGFVPASQISLSRRASMGSGESPEQRWSKMVGEEIDVCVIEVDRERRRLILSERVATPETRETLKERVIETLAEGEIRTGRVTSLADFGAFVNISGADGLVHLSEISWDRIKHPSEVLQVGQEVKVKVISVDREKRRIGLSIRQTQGDPWLERAAKYQVGMLVEGVITRLTKFGAFAKLDEDIEGLIHISEISEKRIEHPKEVLKEGDKVTLRIVKIDPENHRIGLSLRRVDSQAYTDLDWQALEEALKDLDTSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X9</accession>
    <name>E8N2X9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsB</name>
        <name evidence="7" type="ordered locus">ANT_31030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561470.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31030"/>
    <dbReference type="EnsemblBacteria" id="BAJ65129">
        <property type="protein sequence ID" value="BAJ65129"/>
        <property type="gene ID" value="ANT_31030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31030"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_0"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="278" mass="31408" checksum="6FCD5A11FD191A28" modified="2011-04-05" version="1">MATVISMKALLESGVHFGHRTNKWNPHMRPYIFTERNGIHIIDLQQTVKALNTAYNLVRDTVANGGTVLFVGTKRQAQETVREEAERCGMPYVVERWMGGILTNWITFYQRIQELERMERMRDSGELSRLTKKEGLLIQREIDRLEVRLGGIRKMKRLPDLLFVVDVDREATAVHEANKMGIPVIALVDTNCDPRGVDYVIPSNDDAIRAIKLLVGKIADAVNEGKAYRKEEVSEESAPVDMGAVTVGVEEEVSDEDLLGESTLAKMKGFSEDEFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y6</accession>
    <name>E8N2Y6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561477.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31100"/>
    <dbReference type="EnsemblBacteria" id="BAJ65136">
        <property type="protein sequence ID" value="BAJ65136"/>
        <property type="gene ID" value="ANT_31100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31100"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_6_0"/>
    <dbReference type="OMA" id="WESALPY"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225432" evidence="1">
        <location>
            <begin position="27"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="161"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="646" mass="70242" checksum="1D308C20DB423218" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z6</accession>
    <name>E8N2Z6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_31200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561487.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31200"/>
    <dbReference type="EnsemblBacteria" id="BAJ65146">
        <property type="protein sequence ID" value="BAJ65146"/>
        <property type="gene ID" value="ANT_31200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31200"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260410_0_0_0"/>
    <dbReference type="OMA" id="TRCATYN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="965"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="937"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ65146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1314" mass="144592" checksum="EDED5C744ABE0BDD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N313</accession>
    <name>E8N313_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561504.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31370"/>
    <dbReference type="EnsemblBacteria" id="BAJ65163">
        <property type="protein sequence ID" value="BAJ65163"/>
        <property type="gene ID" value="ANT_31370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31370"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217773_0_0_0"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225254" evidence="1">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="227" mass="24855" checksum="2087811B17B0EB97" modified="2011-04-05" version="1">MRKQFFLPVFLCGLMLLSALACRFLPFQKSDSPLLSPTPSSANTFFSATAPRASKTPPVAALPLSPERFTETPVPTVETLPTPQENLPLPAGGCPENSGKIVFSYDPRDAPSVGYGIYLMDSDGSHRLRLSAEDALTDSQPAWSPEHCRIAFVRFNHEGSDDIFLMSADGGSVLQITRHPARDTFPDWSPDGMQISFISDRDGSRNLFVMDVNGEHVRQLTDAQSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N336</accession>
    <name>E8N336_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561526.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31620"/>
    <dbReference type="EnsemblBacteria" id="BAJ65186">
        <property type="protein sequence ID" value="BAJ65186"/>
        <property type="gene ID" value="ANT_31620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31620"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_0"/>
    <dbReference type="OMA" id="EPIKVFN"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="5"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="325" mass="36270" checksum="4EE6CF52DF3B71F9" modified="2011-04-05" version="1">MARYLVTGAAGFIAARVCEMLLERGDEVIGVDNLCTAYDVRLKHYRLNRLLPRENFTFHGMDISDRRGVDALVQASAPLDGIINLAARAGVRASVEDPWVFVETNITGTLNLLEAARRYGVNKFILASTSSIYGENAPLPTPEDAPSDRPLQPYSASKKGAEALCHAYHFLYGLDVTIFRYFTVYGPAGRPDMVMFRFTQWITEGRPVHLNGDGEQSRGFTYVDDIARGTLLGLKPLGFEIINLGGHEVITINQMIARLEQYIGRKAQVVRHPAHRADMLANQADVSKARALLGWEPQVGLDEGMRRLVDWYMAERSWAKDILTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N348</accession>
    <name>E8N348_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561538.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31740"/>
    <dbReference type="EnsemblBacteria" id="BAJ65198">
        <property type="protein sequence ID" value="BAJ65198"/>
        <property type="gene ID" value="ANT_31740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31740"/>
    <dbReference type="HOGENOM" id="CLU_1007016_0_0_0"/>
    <dbReference type="OrthoDB" id="2182225at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="276" mass="29354" checksum="991061ACF78A76EE" modified="2011-04-05" version="1">MNDEEPRGNLYLLTGLVLGLAVGLLISLVISPVKFVDIDPSAMGEAYRSEYRLLIAQAFQSDGNLQRAQDRLALLREEDPARVLAMQAQQMVGEGASPADARALALLAAALTNPQSVAFTPQPSPTLPAGEDHQPTPEVGQAVFTPTPPLPTRTPQPTFTPRPTATPPRALDAPFVLDSRQDVCDGSLPAGRLAIEVLDRDGNPLAGVPVQVVWGQNQSSLFYTGLAPEISLGYADFQMEAGMVYTLRVGTVSETLTDLAIPACGGGVRVVFREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N360</accession>
    <name>E8N360_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase chain L</fullName>
            <ecNumber evidence="9">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nuoL</name>
        <name evidence="9" type="ordered locus">ANT_08400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559266.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08400"/>
    <dbReference type="EnsemblBacteria" id="BAJ62874">
        <property type="protein sequence ID" value="BAJ62874"/>
        <property type="gene ID" value="ANT_08400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08400"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_0_0"/>
    <dbReference type="OMA" id="LIGFWQH"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="151"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="665" mass="72065" checksum="BCD85EFFB0922766" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N379</accession>
    <name>E8N379_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62893">
        <property type="protein sequence ID" value="BAJ62893"/>
        <property type="gene ID" value="ANT_08590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08590"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728910_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="137"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="379" mass="43506" checksum="ED49C0BC2C25F573" modified="2011-04-05" version="1">MDKDIPMRSFMQQFFDDETIADKAAEIGQAMLAARSLQLTEIAVKMRGSSAASYKRIQRFLRGIDPRAMLWRLFCEQAEYVMGDPTEIERPQARKTEYVGTLKDGKTKGFWMLLLATPYRGRAIPCGLLTYSSRTIGAGLSSRNLNHVRAFAELKDLLGERPLVLDREFSYLELLLHLVEEGVNFVFRLNQGSHPPKFWDADGKEVVLSLSPGEKVSHSALWYKGKVCVNLIGVWKKGLAEPLWVMTNLEPERAWQIYLSRMKIEQTFRDLKGLLGMTRLMNKRQENMEKMLALLLLVYAIALLVGENLRDRLYGLPTHPQERVDLVPHQIGKKWRRYSGLFILLNQKRRLPTREWQAIINCALQSFAAIVHPPVPTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N398</accession>
    <name>E8N398_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_08780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559304.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08780"/>
    <dbReference type="EnsemblBacteria" id="BAJ62912">
        <property type="protein sequence ID" value="BAJ62912"/>
        <property type="gene ID" value="ANT_08780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08780"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="ATMLKPN"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="235" mass="25753" checksum="E61626C14AFCE48A" modified="2011-04-05" version="1">MNAQDWVIEATNLTKIYQMGKVQVPALNGVSLKIARGEVVAIMGPSGSGKSTLMNLLGCLDRPTSGEYILDGKVVSKLRDDALAHIRNRKVGFVFQQFNLLPRATALANVELPLRYGGANHDRKQRAYAALEAVGLADRVRHKPTELSGGQQQRVAIARALVNDPAIILADEPTGALDSKTGEEIMHLLLELNRQRGTTLLLVTHDPRIAAYAQRTIFLRDGLIVEENHEHPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H6</accession>
    <name>E8N3H6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_09560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559381.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62990">
        <property type="protein sequence ID" value="BAJ62990"/>
        <property type="gene ID" value="ANT_09560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09560"/>
    <dbReference type="eggNOG" id="ENOG502ZQVN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1264756_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="25423" checksum="427ABA113C3188D2" modified="2011-04-05" version="1">MTPTRKPLWIWLSLSVGLAVLLTAVLREQIRAVIVEPLSYVIWYVQLILNTVPQPLFWAVMILGGIYLIGRAMLEGIPSTERLSEPQNDIASTSRYRYWLWYVATFSKNRFASENLARHLAHLIMEIIGYQEHLSREEMEKKIREGTLNVSEEILEFLRTRRLLTSRQSPDSIKGWLERMQGRLFHLPGSIPFSDQQETFHRLKQLVNFIEERIGGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J4</accession>
    <name>E8N3J4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">minD</name>
        <name evidence="8" type="ordered locus">ANT_09740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559399.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09740"/>
    <dbReference type="EnsemblBacteria" id="BAJ63008">
        <property type="protein sequence ID" value="BAJ63008"/>
        <property type="gene ID" value="ANT_09740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09740"/>
    <dbReference type="eggNOG" id="COG2894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_1_0"/>
    <dbReference type="OMA" id="CESAKAY"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="7">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="267" mass="29107" checksum="9A330E2D0C711EBD" modified="2011-04-05" version="1">MTASVITFTSGKGGVGKTTTTANVAVALALLGKKVVCIDGDIGLRNLDLVLGLENRIVYDVVDVVEGRCRLRQAMIRDKRLPELYLIPAAQTRDKNALSPSDMVRLCDELRSDFDYICIDSPAGIERGFRNAIAPADQVVVVTNPEVSAVRDADRVIGLVEAEEKGPARLILNRVNPAMVKRNEMLSPEDVLELLAIDLLGIVPEDENVVISTNRGQPIALNGKTRAGEAFHNIARRLNGEDVPLMKLDDKQDFFSKLARMMRSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K9</accession>
    <name>E8N3K9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsK</name>
        <name evidence="7" type="ordered locus">ANT_09890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63023">
        <property type="protein sequence ID" value="BAJ63023"/>
        <property type="gene ID" value="ANT_09890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09890"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_9_7_0"/>
    <dbReference type="OMA" id="EHEVEYE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="380"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="692"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="397"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="718" mass="78439" checksum="331C78F4D15AE6CA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L2</accession>
    <name>E8N3L2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_09920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559417.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09920"/>
    <dbReference type="EnsemblBacteria" id="BAJ63026">
        <property type="protein sequence ID" value="BAJ63026"/>
        <property type="gene ID" value="ANT_09920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09920"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="ASHNMAE"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="34374" checksum="2716ADEBB9611039" modified="2011-04-05" version="1">MIYAEGLTKIFDDFIAVNQVSFSVAEGRVLALLGKNGAGKTTTIRMLSSILKPTSGSAKVAGYDIVLEAQKVRASVGVLTEHHGLYSRMTLWEYLEFFGSLYGMSALEVRQRAKPLLEEFELEGTEKKRLGEFSKGMRQKLALVRALLHNPPVLMLDEPTSAMDPESARVVRNAIAHLRGQGRTILLCTHNLVEGEELADDVAIIHHGRVILQGSLEEVKEQQLGAPEFLARLARPLNGATLRLPEGVSVTARGEDWVRFQVSHPRAHNPELLRALLHQQVEVLSFQEVPRSLEEVFLKVVRSEKENVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P1</accession>
    <name>E8N3P1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpsE</name>
        <name evidence="11" type="ordered locus">ANT_10210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10210"/>
    <dbReference type="EnsemblBacteria" id="BAJ63055">
        <property type="protein sequence ID" value="BAJ63055"/>
        <property type="gene ID" value="ANT_10210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10210"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_0"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="178" mass="19408" checksum="8BD49FB603C5A2BE" modified="2011-04-05" version="1">MMDMMEYPSIETQYDERVIEIARVAKVVKGGRRFQFRVTVVAGDNKGHVGLGVGKANAVPDAMRKATERARKNMRKISMFGTTIPHEVIGKVGGSKVLLKPASPGTGVIAAGGVRAVLEAAGIRDILTKSLGSSNVLNVVQATFEALDQLKFPEEEAAHRGKAVEEILPFWERRKKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P2</accession>
    <name>E8N3P2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpmD</name>
        <name evidence="8" type="ordered locus">ANT_10220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559447.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63056">
        <property type="protein sequence ID" value="BAJ63056"/>
        <property type="gene ID" value="ANT_10220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10220"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_2_1_0"/>
    <dbReference type="OMA" id="GKQNQRD"/>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="66" mass="7427" checksum="298794F5BB36E8B7" modified="2011-04-05" version="1">MTEATEPKMLKITLVKSPIGYSERHKATVRALGLRKLHQSVVHPDSPSLRGMLLKVNHLVKVEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P6</accession>
    <name>E8N3P6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ordered locus">ANT_10260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10260"/>
    <dbReference type="EnsemblBacteria" id="BAJ63060">
        <property type="protein sequence ID" value="BAJ63060"/>
        <property type="gene ID" value="ANT_10260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10260"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_0"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="270" mass="28982" checksum="C238D6A04D33EDF9" modified="2011-04-05" version="1">MSWDRQITIKTPQELEIMREAGKINAEALAAARAAIQPGATTADVNAAAEAVLKKYGVYSPFKNYPGPYPYPASTCVSINDELVHGIPSKTRKIKEGDIVTVDCGTVYRGFVADAAFTVGVGQISEVARKLLEVTEGALYAGIRQMKPGNRVGDISAAIQHYVESRGFHVTREYTGHGVGRRMHEGPQVPNYGVPGRGLLLRPGLTIALEPMVLVGTWQTRVLADEWTVASADGSLTAHFEHTIAVTEDGPVILTLLGEDESGQKRASGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3V7</accession>
    <name>E8N3V7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrA</name>
        <name evidence="10" type="ordered locus">ANT_10870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559511.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63121">
        <property type="protein sequence ID" value="BAJ63121"/>
        <property type="gene ID" value="ANT_10870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10870"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_0"/>
    <dbReference type="OMA" id="EIDANKH"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="9">
        <location>
            <begin position="9"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="804"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="847"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="895"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="981" mass="107494" checksum="4E32454B6F9A385B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X2</accession>
    <name>E8N3X2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NagC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559526.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11020"/>
    <dbReference type="EnsemblBacteria" id="BAJ63136">
        <property type="protein sequence ID" value="BAJ63136"/>
        <property type="gene ID" value="ANT_11020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11020"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_3_0"/>
    <dbReference type="OMA" id="LGHINQP"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="407" mass="43175" checksum="7AFA9C34877BA278" modified="2011-04-05" version="1">MSTTFWSVPTQNLKNLNKHAIIDLIRFSSGGISRVELARRMGLTRAAVSAIIDDLIEIGLVRESEGTYPSGRKPIVLEINPMLGHVVGIDMGASHVMLLLADFSGRQIHEIEAPLDINEGPVVCLDKVARLVDQLLAEAHMTVNEISAFGVGVPGPIVAKEGMVSGPPIMPGWDRYPIRDHLQELWGKPVSLNNDAELGAVGEWAYGAGRGERYLCYIKVGTGIGAGLLLDGQIYRGATGCAGEIGHITIDENGPICTCGNRGCLEAIAGGNAIIRKVKESVRLGQRTILADLVHQDKLGVGDVMNAARHGDHLAQRITAEAGMHLGTAIANVINLFNPSMVIVGGSVGQIGDLLLEPVRLTVQRRSLSVASKNVRITAALLGPHSCAIGAVVQALSIVLHQIADKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Y2</accession>
    <name>E8N3Y2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559536.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63146">
        <property type="protein sequence ID" value="BAJ63146"/>
        <property type="gene ID" value="ANT_11120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11120"/>
    <dbReference type="eggNOG" id="COG4813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084426_0_0_0"/>
    <dbReference type="OMA" id="WNEFRHE"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009381">
        <property type="entry name" value="Trehalose_catabolism_ThuA_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030013">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="241" mass="27481" checksum="DB5C39EAC8011978" modified="2011-04-05" version="1">MSQSIRVTVWNEGVHEKTHEEVKRVYPHGMHAVLAQALQEAGFFVRTATLDDPEHGLTEEVLAQTDVLTWWGHMAHHAVQDTIVDRVVKRVQEGMGLIVLHSGHMSKPFLRLMGTTGALKWREAGEKERLWVVNPAHPIAAGLPEYIEIPHEEMYGEHFDIPAPDELVFISWFKGGEVFRSGCCWTRGAGKIFYFRPGHETYPTYYQKEVQQVIINAVKWAAPGNLPAITYWHKPNPLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N410</accession>
    <name>E8N410_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_11400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63174">
        <property type="protein sequence ID" value="BAJ63174"/>
        <property type="gene ID" value="ANT_11400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11400"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012814_1_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="7">
        <location>
            <begin position="585"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="7">
        <location>
            <begin position="739"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="864" mass="94786" checksum="4608D42616EA7909" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8N466</accession>
    <name>E8N466_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">metH</name>
        <name evidence="30" type="ordered locus">ANT_11960</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559618.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63230">
        <property type="protein sequence ID" value="BAJ63230"/>
        <property type="gene ID" value="ANT_11960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11960"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_4_0_0"/>
    <dbReference type="OMA" id="ADCIAMS"/>
    <dbReference type="OrthoDB" id="118138at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02082">
        <property type="entry name" value="metH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 20 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="25">
        <location>
            <begin position="7"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="26">
        <location>
            <begin position="348"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="29">
        <location>
            <begin position="636"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="28">
        <location>
            <begin position="736"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="27">
        <location>
            <begin position="887"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Methylcob(III)alamin binding" evidence="22">
        <location>
            <begin position="746"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="22">
        <location>
            <begin position="1159"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21 23">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="749"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="854"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="BAJ63230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1172" mass="129525" checksum="7B3CF64FC4279B92" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4M2</accession>
    <name>E8N4M2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559772.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13560"/>
    <dbReference type="EnsemblBacteria" id="BAJ63386">
        <property type="protein sequence ID" value="BAJ63386"/>
        <property type="gene ID" value="ANT_13560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13560"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1110841_0_0_0"/>
    <dbReference type="OMA" id="NDNTHRI"/>
    <dbReference type="OrthoDB" id="1022681at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="234" mass="26264" checksum="797564BDDFCF7013" modified="2011-04-05" version="1">MLRKLTRWIFLGIGTTFLILGLWSYSRPVPANASTEILQALGEEYDPYLIQVIEPSTPTNTNLPDTYQYALSPSLIDQTLDKALNIPETLIVPAIQLRAPVQVTGSRKILVRNTVYEQWLVPDTFAAGWNPSSGTPGSKGNVVLYGHHNINGAVFARLYQVQRGDELIVVSRGLEFHYKVTDIVKIKEKDVSFAQMLQNAELLKDTNEERLTLITCWPPYESTHRLIVIATNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N3</accession>
    <name>E8N4N3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fucose_iso_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63397">
        <property type="protein sequence ID" value="BAJ63397"/>
        <property type="gene ID" value="ANT_13690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13690"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045643_0_0_0"/>
    <dbReference type="OMA" id="CNAPIKP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_C" evidence="2">
        <location>
            <begin position="342"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="478" mass="52602" checksum="E6389436DC9C8DA0" modified="2011-04-05" version="1">MHMKPVTLGVIVGNRGFFPDHLCITGRKTILKVLEEEGIHPIIIDENETKVGSIVTLNDAQKCAELFKAHRDEIDGILVTLPNFGEEKAIANTLRWAGLNVPVLIHAFPDDMTRMTVADRRDSFCGKMSVCNNLTQYGIPFSLTSLHTVNPESESFRADLRRFAAVCRVVRGLRNARFGAIGARPAAFNTVRYSEKLLERTGISVETIDLSEIFGRAARLHADDPKVKAKIEQIQSYVPTKNTPGEALIRMAKLGVVIEDWMAENQLVASALQCWTSMEEFYGVVPCTLMSMMSNSLVPSACETDIAGAVGMLALALASGKPSAIVDWNNNYGDDPDKGVIFHCSNLPKDLFLEAAASQEDAPQMDYQAIIAGSVGKENTYGTVVGRLKAVPFTYCRVSTDDLHGRILAYVGEGHLTEDTLKTFGGYGVVHVPNFQKLLAYICENGFEHHVAINPSMVADAVNEAFTKYLGWQVYYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4P2</accession>
    <name>E8N4P2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">atpG</name>
        <name evidence="10" type="ordered locus">ANT_13780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559790.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63406">
        <property type="protein sequence ID" value="BAJ63406"/>
        <property type="gene ID" value="ANT_13780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13780"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_0"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="300" mass="34054" checksum="94AA719CA9FD8059" modified="2011-04-05" version="1">MASTREMRLRIRSVKNLSQVTKALETVSASRVRKAIQANNSSKPYAEKAWKVLVHLARQPGHDALHPLLADRPVVRRALVILVTSDRGLAGSYNANIFRHTLHEFSQKPYPVDFVAVGRKGRDLLLRRRKNVIAEFSDLPSPPLYREVAPIASLAIEDFEKQKYDEVYICYTQFINMMRYEPVTRRLLPLKILYKDEAPDIHTLDATHRTHSVFSFEPDEGEVLSNIVPHFTGIQIFQAILSAQASEHAARMIAMRNATESAQELIQSLQLEYNKLRQTLITNEMLDIAGGANALAQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4W1</accession>
    <name>E8N4W1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xdh</name>
        <name evidence="4" type="ordered locus">ANT_14470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63475">
        <property type="protein sequence ID" value="BAJ63475"/>
        <property type="gene ID" value="ANT_14470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14470"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_3_0"/>
    <dbReference type="OMA" id="SMGTRSW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="999" mass="109260" checksum="0A32D6A07A5446D3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N503</accession>
    <name>E8N503_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63517">
        <property type="protein sequence ID" value="BAJ63517"/>
        <property type="gene ID" value="ANT_14890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14890"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_7_2_0"/>
    <dbReference type="OMA" id="FHGFSDH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="288" mass="32601" checksum="035238B693F66262" modified="2011-04-05" version="1">MCSMTAKLHIHESMWSTPDQQSIYTRRWTPLQESVRAVIVLVHGLGEHCARYDHVAAFFAEQGMATFGFDHRGHGRSDGKRGHIPSYERAMQDIDHFLEEARRAYPNAPLFLYGHSMGGNMVLYYALARQPQNLRGVICTSPGLAVGTPLSPALQAVARVLYMVAPSFTMPNGLNLSHLSHDPQVVEAYQKDPLVTPMVSARLGLEMMDKGKWILEHAEDFPLPLLLLQGGAERIVSPDAVRAFARRVPPERITYREWEHLYHELHNEPEKAEVLNTMLDWLNRQISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N582</accession>
    <name>E8N582_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_15680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559977.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63596">
        <property type="protein sequence ID" value="BAJ63596"/>
        <property type="gene ID" value="ANT_15680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15680"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_0"/>
    <dbReference type="OMA" id="HRYAKNF"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="125"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="337" mass="38788" checksum="653C99A4EB1E74C7" modified="2011-04-05" version="1">MEHENPQNSSPENTLLSTSIFQYLESVSLSRSPHTFRTYKNALNAFIQCLIEHDLDPNATLVKNFDESPLTWFSVYLKNHSPATETLYLTAVKNFYEYLAAEKLADINLPRVKLLIRQRSRKPGQRLPQFPKDYIEILLEKMQSFIPDATMDETERIRFLRDRAFLLTLADTGLRVHEACNLRRGDMDWNEGKALIIGKGNREAIVRFSTRTIHALKEYLTQRAALDSSSGKPLSSLPLFARHDKGSGKKIKPITTTTGRNIVKQRVKEFLDEEISLEITPHSFRHYFVTRVLVSSGNLKLAQELARHRNIAVTQRYAHLSNEELDQGYWQAIENNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A2</accession>
    <name>E8N5A2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_15900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559996.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63616">
        <property type="protein sequence ID" value="BAJ63616"/>
        <property type="gene ID" value="ANT_15900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15900"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_3_1_0"/>
    <dbReference type="OMA" id="ADYRYLW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="345" mass="38196" checksum="F12D1FB6B3C61CB5" modified="2011-04-05" version="1">MNTSTQRSDSSFSWFFQWGIGILLTGGAIFILSRIIDLNEFIVVFRSLPLKTLLMVWGIYLVSMVIRAWGWQNLLQRRVGLWRAVLLMNEGYFLNNVLPFRLGEFGRAYLAGKYGKSGTFSAFSTVVVERAYDLAFASFLLLSSLPFAFQMRWAQNAAIALLGVIVAGLVGLYFAAHHREKIEQKIIHLASGSVFVQRWVYPTVHGMLDGFSVLTRFEFFIFSLLGIGFSWFLAIFRDFFVLRALDPSIPFWVTLLAISSSNLGGALPSMAASLGTFEGAATGALSLIGLKPELGLVYALVIHIVHLVSTTIIGGIGISQEGKTIQQLITEIRNSQRSAMNANSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A5</accession>
    <name>E8N5A5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_15930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559999.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15930"/>
    <dbReference type="EnsemblBacteria" id="BAJ63619">
        <property type="protein sequence ID" value="BAJ63619"/>
        <property type="gene ID" value="ANT_15930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15930"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029423_0_1_0"/>
    <dbReference type="OMA" id="RWFLITT"/>
    <dbReference type="OrthoDB" id="1213919at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="292" mass="32893" checksum="D4A320D25351B87C" modified="2011-04-05" version="1">MMSALLKAMRPRQWTKNIFVFAAVVFDRQLSLHNFDPLLRSFGAFLIFCLLSSSVYLINDLIDLEADRAHPTKRNRPIASGKLPVSVALMTAGGIIVIIIPLAFLLSKDFGVITLVYFLINLAYSGWLKHIPLIDVMIIAAGFVLRVAGGVTVIEVQRFSPWLYVVTTLLALYLGFGKRRAELTLLEENANSHRRVLDGYNLPLLDQLITIVSSSTILAYSLYTFSAPNLPDNHTMMLTIPFVMYGIFRYLYLIQIKQEGGAPEEMLLSDRPLQVDLLLYGLAVLLIFYYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C6</accession>
    <name>E8N5C6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560020.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63640">
        <property type="protein sequence ID" value="BAJ63640"/>
        <property type="gene ID" value="ANT_16140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16140"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_2_1_0"/>
    <dbReference type="OMA" id="RNWGLYE"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="189"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="339" mass="38016" checksum="3C5F2487129DF4C8" modified="2011-04-05" version="1">MDFPISPLRFIIVGQLRKTFIALPNEEFVENQPGGNAIYAAVGAAVWEKDIGIVARVSQDFPEEWLQTLKRWNFDIRGIQRLNEIIDHREFFAYQNPAFEESENPEVYLTNLNRPYPRELIGYKANPGLLDSRTKPGAFTVRSHDIPSEYLDALAVHICSIDYLSHILLPTTFRQGQINTISLDASAGYMDPAFEDDLPLLVNGLTVFHTSEKKISRLFSGKTGNLWDMAEWIGSMGCELVVIRRGVQGQYLYESSSHKKWIIPAYPSNVRCPVGAGDAFCGGFLVGYYTTYDPIQAALQGSISASFVVEGTAPFYALEALPGLARARLEVLRERVRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S6</accession>
    <name>E8N5S6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_17640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560168.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17640"/>
    <dbReference type="EnsemblBacteria" id="BAJ63790">
        <property type="protein sequence ID" value="BAJ63790"/>
        <property type="gene ID" value="ANT_17640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17640"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_6_0_0"/>
    <dbReference type="OMA" id="CHIGAFS"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="417" mass="44587" checksum="8873EEB5C7C67CFA" modified="2011-04-05" version="1">MIKKTSARLVYLILSGGNTLADTIMFTVNMVYFVEIIGLSPLQLVLVGTVLEGAILLFEIPTGVLADTIGRKVSIVTGWFIMAGGFLLVGIVPELWAVFIGQVLWGLGYTFTSGATEAWLADEIGEDLVGKINIESGQINRILGLIGSAISVAIASVALNLPIVIGGLMYLFLAVFLLFTMPETQFTPRYKSSKSLETPFQSFIQTFQEGVKAVGKSPILLALLLVELFIGAASEGYDRLSSAHLLKNFQIPPIGALQPVVWFGILNITGSLASFSTTAMFRKKLEVISQSYQLAARYLVLLHSLGIAMVVMLALTGNFYAAIAAILVKGVMGALIFPLYNAWLVQNILPTTRATVISIVGQANAFGQVVGGPGIGAVGNRSLRLAILLTALLSIPALPLYTSAQKKQTVFSPESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5S7</accession>
    <name>E8N5S7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_17650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63791">
        <property type="protein sequence ID" value="BAJ63791"/>
        <property type="gene ID" value="ANT_17650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17650"/>
    <dbReference type="eggNOG" id="COG0371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038362_1_0_0"/>
    <dbReference type="OMA" id="DFICRST"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="480" mass="53978" checksum="B58907B491417165" modified="2011-04-05" version="1">MRGKSGFIIRFMLSKFFTHPETYKSLSPSDLCHTSLGCPYCGKVHTIPIEFAAAEPGVLVGDAVNVLRRHAGSSLVPLLYDRAIEPLIAEKVIAPLQNQGFSIHPIGIGSPGVLLDTSVELAHEAMEQIPSAASFLIGAGSGVICDLTKWVATQTHLEYALIGTAPSMNAYTSITATITEGEVKISHLLTPPKAVLLDVNILRDAPQEMIWAGWGDLAARAVCNADWRLANFFHGTYFCPFPYELTEKYQNDVFAVASQITQRDLLAFQLFADAILISGYSMTLLNGETSPSSGSEHVLSHFWDFLSHHRGLPKNLHGVQVGIGTLIMLAFYEAFRSVNPHSLQPEKILKHRKSFGRLVDENQRLYGDAATRFNQILEKKYRKDEEILHRVQRVKMQWQFLWEILDPYLTPFEKVKRTFIEAGFPVSLQTIQRNKEEVLEAMIKGPFYRPRYTILDLAWELGVLEDLAEEALKRVFYQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y4</accession>
    <name>E8N5Y4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_18220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560225.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63848">
        <property type="protein sequence ID" value="BAJ63848"/>
        <property type="gene ID" value="ANT_18220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18220"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083554_0_0_0"/>
    <dbReference type="OMA" id="CIYIEAG"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="203" mass="23476" checksum="6BD1123547FB3181" modified="2011-04-05" version="1">MNGLGIIRGLWVTFKHFILTYIEDIRAGKKRYYTQEGILARTRSDVRGAFTIQYPEEKYPVPEEFRYIPFLVYEEGENREKNYRCTSCGICAKVCPPQCIWIVRTTDPNTGKPIPAPAEFYIDVDICMNCGLCAEYCPFDAIKMDHDYEIASYNRFADHIFNKERLGKPLSYYAQIRPQNFAREEAARKAELEAKAARKPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z2</accession>
    <name>E8N5Z2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein Hsp20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="BAJ63856">
        <property type="protein sequence ID" value="BAJ63856"/>
        <property type="gene ID" value="ANT_18300"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="SEHEDHY"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
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    </dbReference>
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        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
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        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="137" mass="15816" checksum="026883CCEBD2CC4A" modified="2011-04-05" version="1">MITVAMRPSYLKNFMNSDKPDYLIVNWRVTGRSHIWQPPTDLLEVDDGYLVRVEIAGMDEEDFEISLDQQTLVIQGTRADTLGQRVYHQMEVNFGDFFTMVELPSPVDPSRATAEYQNGFLLIRLPKTPVKHIRISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z7</accession>
    <name>E8N5Z7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_18350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63861">
        <property type="protein sequence ID" value="BAJ63861"/>
        <property type="gene ID" value="ANT_18350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18350"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026152_3_0_0"/>
    <dbReference type="OMA" id="FNRIHWR"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="207"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="441" mass="49190" checksum="6109201EEA5C1E5A" modified="2011-04-05" version="1">MIVLRKPFWVVLGVFLFALLGGYLVPSGIFPVPTTLQNQTTIRIFTRIAAISGGAIVLGWLWTQASLFGVVVRREARVLRHQVGQIFEERFRVINRLPMVRLWLEITDESDLPGSSGSRVLSLIGPRQQRTYVAYTLLSQRGAFRLGPTRVSSGDPFGLFRKIIDVPGTQELIVLPYVATLQRFPSPLGQFPGGKAILQKATEVTPQAAGVREYFPGDALRSIHWPTSARKNRLMVKEFEQDPQADVWIILDAEAGVHFASSEKITPVRIDQFWLRKSEFAFKLPEDTFEYGVSAAGSIASYYLRQGRSVGLICVGQAFVVLSAERGERQLNKILETLAFLKPNGRLPLMAVVDAEASQIPRASTVVLITPSIHSSLDLAIDTLVVRRMKPVLVHVDAHTFGAGFSSEEFLYRMRLRNIPVLSLKNNVSLIESLEVKNFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Z9</accession>
    <name>E8N5Z9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560240.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18370"/>
    <dbReference type="EnsemblBacteria" id="BAJ63863">
        <property type="protein sequence ID" value="BAJ63863"/>
        <property type="gene ID" value="ANT_18370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18370"/>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008305_1_0_0"/>
    <dbReference type="OMA" id="MPTYQLG"/>
    <dbReference type="OrthoDB" id="946896at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="785" mass="88952" checksum="B08B654DA81882A4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N654</accession>
    <name>E8N654_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560295.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18920"/>
    <dbReference type="EnsemblBacteria" id="BAJ63918">
        <property type="protein sequence ID" value="BAJ63918"/>
        <property type="gene ID" value="ANT_18920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18920"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796067_0_0_0"/>
    <dbReference type="OMA" id="QKMQFVL"/>
    <dbReference type="OrthoDB" id="1714999at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PTHR23222"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="57"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="348" mass="38461" checksum="23646CAE68067190" modified="2011-04-05" version="1">MNISSLTSFFVGAVWFIVFITFGVVILRASRNQPVRGSGRVLVALILFAVFLTTLNAGLVFIEPQERGVVISAVSPEGYRKEPLEPGLRFIIPFAEQVVRYSIANQTYTMSIAAREGQIEGDDSIAARTEDGQEIYVDASVIYAINPTEVVKVHILWQDRYTRDLVRPLARGIIRDAVSQMRVDEVVSSKRAELVKTLNETMAVKLAENGLILRDFVLRNITFSPEYAASVEQKQIAEQQAQQAKFVVEQKKQEAEQARQVAQGQADAAVIRAKGEAEARLIQAEAEAKALEYIANVIKSNPDILNYQYITKLAPNVQVIMTPSNTPIILPYPGSLQAPATTTPTTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N672</accession>
    <name>E8N672_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_19100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560312.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19100"/>
    <dbReference type="EnsemblBacteria" id="BAJ63936">
        <property type="protein sequence ID" value="BAJ63936"/>
        <property type="gene ID" value="ANT_19100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19100"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_3_1_0"/>
    <dbReference type="OMA" id="AGPWHFA"/>
    <dbReference type="OrthoDB" id="1819626at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="38729" checksum="F23E18A53379F753" modified="2011-04-05" version="1">MKRWQFWLGVGISAFFLYLALANLKLTELWETIKYAKYWWLVPGITVYFLGVWVRAWRWHYLLRPLKKIPTTTMFPIVAIGYMGNNIYPARAGEILRAVILKERSGIPISASLATILIERIYDGVVMLAFVFLNLAELTRLTHNAGLGANLDIRTIAIGGSAVFFSALIVFLLCAMFPKQTESFLRLLSKWLPEKFRDKVLSVALKFLSGLEALRSPLEALMIFATTVIIWLFETAKYWFVMHAFPFEVSFFALMLMNGIVNLATTLPSAPGYVGTFDTPGIAVLVAYGVLPEVAAGYTLVLHGALWFPITLLGVYYYLKQPLRWGKDIQHTNKKVIEAEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A7</accession>
    <name>E8N6A7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560344.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19450"/>
    <dbReference type="EnsemblBacteria" id="BAJ63971">
        <property type="protein sequence ID" value="BAJ63971"/>
        <property type="gene ID" value="ANT_19450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19450"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2217526_0_0_0"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="106" mass="12071" checksum="DBD1B3B3E23C69F2" modified="2011-04-05" version="1">MSESTVPEGRRLPTWIIVLSLIVLLAFLGLIGWGLKRSMSGPISIGQKVPEFQMTTFDGQTLRSTDFAGKVIVLNFWASWCKPCEQEARELEEAYQYYKDSGFFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B7</accession>
    <name>E8N6B7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_19550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560354.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19550"/>
    <dbReference type="EnsemblBacteria" id="BAJ63981">
        <property type="protein sequence ID" value="BAJ63981"/>
        <property type="gene ID" value="ANT_19550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19550"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036690_0_0_0"/>
    <dbReference type="OMA" id="VEDQEFS"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="4">
        <location>
            <begin position="338"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="531" mass="59981" checksum="536AF09BC2EF5166" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C6</accession>
    <name>E8N6C6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560363.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19640"/>
    <dbReference type="EnsemblBacteria" id="BAJ63990">
        <property type="protein sequence ID" value="BAJ63990"/>
        <property type="gene ID" value="ANT_19640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19640"/>
    <dbReference type="HOGENOM" id="CLU_1802064_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="143" mass="16279" checksum="886B29C82DE6DEDA" modified="2011-04-05" version="1">MLNARSPAEILSLFCEIASFPYQAFLLRHEKSSDTFEIISQWRPQPHIAAKKISADILLKTVFYPEKVLSIPANTEIPNTLRELKAFLPPEEGMVLIPLMARDEPEGCIFLIMSGKAHWEKTNEREILQLAKVAALVLHRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF8</accession>
    <name>E8MXF8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20130"/>
    <dbReference type="EnsemblBacteria" id="BAJ64039">
        <property type="protein sequence ID" value="BAJ64039"/>
        <property type="gene ID" value="ANT_20130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20130"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478070_0_0_0"/>
    <dbReference type="OMA" id="WYSSATI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="501" mass="55466" checksum="9A3C6CD4AF3AC855" modified="2011-04-05" version="1">MRLMIFVPSKLALHRNLMKTKFFWIIFLAFFCLILWSSLLSPETAKAQGGAITWEDPIPLSNPSVQAWHPTIAADLAGNVHIMWSQSTSMERPVGYGDTLYYTRWDGKKWIAPVDVLVSPEAGLGAEFPDITITPDGTLHAIWGTGGTNSRLYYSRAPACCAEDPRNWSKPFMIGIGVNETSALIHDSGGRLYVMYASLDTKEPIFLRSDDGGNTWSKPVRLVSGIRQSNEYTAYTRLAVDGRGVLHAVWTIMPFPGKRVVYAQSSDRGMTWTDPISIDEYSPEKYLEGFGPFLIDVEAVGEQEIHLTWDGAPTVERHHVWSRDGGKTWSEPDTFIPELTGGGRALWNDMAADSQNTLHAVSIKQPWHAQWLGNGWSPSTPIGQRGFAENMRITVSEGFILHVVWLEVVEGIPSVVYYNRGITQAPPLPKQTLPSSPLLETETLFASPSPSPTDTFIPTIVNPIPSKNASTNPALGAFISLGVVSLFLIGIVFWIARKHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM1</accession>
    <name>E8MXM1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560472.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64102">
        <property type="protein sequence ID" value="BAJ64102"/>
        <property type="gene ID" value="ANT_20760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20760"/>
    <dbReference type="HOGENOM" id="CLU_2614271_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="78" mass="8626" checksum="35ABB14B304C2317" modified="2011-04-05" version="1">MIASTPEEALMDIEQILQSTLRPIQPDPGFVGKLNQRLTTPTNVVLEQPPSRWRGVLLVSIGLFAGLVLLTIFQRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM2</accession>
    <name>E8MXM2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560473.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20770"/>
    <dbReference type="EnsemblBacteria" id="BAJ64103">
        <property type="protein sequence ID" value="BAJ64103"/>
        <property type="gene ID" value="ANT_20770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20770"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_11_1_0"/>
    <dbReference type="OMA" id="VYGTRWC"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="85" mass="9810" checksum="5A13A6A2BC57F817" modified="2011-04-05" version="1">MADEIIIYGTSWCGDSRRARRIFDDYHIPYRWVDIDEDMEGRKFVESVNNGFRSVPTIVFPDGSILVEPRSTELKRKLGVDSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR3</accession>
    <name>E8MXR3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_21180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21180"/>
    <dbReference type="REBASE" id="32152">
        <property type="entry name" value="AthUNI1ORF21180P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64144">
        <property type="protein sequence ID" value="BAJ64144"/>
        <property type="gene ID" value="ANT_21180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21180"/>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002539_1_1_0"/>
    <dbReference type="OMA" id="IKSPREC"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="RM_methylase_Eco57I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="669"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1199" mass="137898" checksum="BC9BC7C85B0E749D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT5</accession>
    <name>E8MXT5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ64166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560536.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21400"/>
    <dbReference type="EnsemblBacteria" id="BAJ64166">
        <property type="protein sequence ID" value="BAJ64166"/>
        <property type="gene ID" value="ANT_21400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21400"/>
    <dbReference type="eggNOG" id="COG4737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110687_1_2_0"/>
    <dbReference type="OMA" id="DEDEYHK"/>
    <dbReference type="OrthoDB" id="2029118at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009387">
        <property type="entry name" value="HigB-2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039032">
        <property type="entry name" value="HigB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="106" mass="12552" checksum="93C167B06470FDAC" modified="2011-04-05" version="1">MHFIETSVFTRRILELMSDDEYRALQIFLSTRPDAGDIIPGSGGLRKVRWHTGTTGKRGGIRLIYYWVVRDDTILLLFAFRKNERSDLTPEQIRILRRIVEEEYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU9</accession>
    <name>E8MXU9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ64180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64180">
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        <property type="gene ID" value="ANT_21540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21540"/>
    <dbReference type="HOGENOM" id="CLU_856977_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="324" mass="34955" checksum="85F2DDF1F0332B39" modified="2011-04-05" version="1">MMKINGRFVVSKFWQITLMGLLIAVGIALFPQAQCAVAQTCSAPRDLWCGSGKCCDPAAGFTVVVGCSKVGNICVEDTKQVPVRCQHSSNCEVTEVLDSTYKNRLSGGYWTVGSCPSFFPQGGSCGTPLTNTNSVRATCCTGSSGSGGGCTPSYAPPTIDDTYTVDPPYPVPWRQEQPPYGEALGMTINDIKAHGGADTACGSGQANITSLTVWVELTEESRDWIVYTLGQRYPGAHVLGEYPQYPERPDDPLHPYAHCAWTYGTSGINTPNAELDCRFFRPWDPGDYTVHVTACQSDGKCTTKVLPNPIKVYLLESRLLAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW8</accession>
    <name>E8MXW8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560569.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64199">
        <property type="protein sequence ID" value="BAJ64199"/>
        <property type="gene ID" value="ANT_21730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21730"/>
    <dbReference type="HOGENOM" id="CLU_2731161_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="71" mass="8411" checksum="4A89D3A5D7D64AEE" modified="2011-04-05" version="1">MQNSVLVFDLERLDELRREAERYCDARLWEMLADGYEFYGLLSTASACRRRAEHYKRQQEVIHEADTGMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY03</accession>
    <name>E8MY03_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-plastoquinone oxidoreductase, chain 5 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_22080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560603.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22080"/>
    <dbReference type="EnsemblBacteria" id="BAJ64234">
        <property type="protein sequence ID" value="BAJ64234"/>
        <property type="gene ID" value="ANT_22080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22080"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_3_0"/>
    <dbReference type="OMA" id="FRIFAMI"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="582" mass="61992" checksum="FEA67F1DC1418FBC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY06</accession>
    <name>E8MY06_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22110"/>
    <dbReference type="EnsemblBacteria" id="BAJ64237">
        <property type="protein sequence ID" value="BAJ64237"/>
        <property type="gene ID" value="ANT_22110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22110"/>
    <dbReference type="HOGENOM" id="CLU_2986463_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="57" mass="6682" checksum="8FD64CD203B29E23" modified="2011-04-05" version="1">MFAEGLNEFNTFLFPRGVEFVFSTPFILIVDMYIQFDDKLPLLSGNLSHDIYRSFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY59</accession>
    <name>E8MY59_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560658.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64290">
        <property type="protein sequence ID" value="BAJ64290"/>
        <property type="gene ID" value="ANT_22640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22640"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_19_0_0"/>
    <dbReference type="OMA" id="IMHAEGE"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="326" mass="36911" checksum="666AC916E82A84A7" modified="2011-04-05" version="1">MKISVIVPCYNEERTIAHLLEALRQQTVGTKAFEVIIADGMSTDATRQVIQNYLQEHAELTVRVVDNPKRHIPSGLNRALEVSTGEIIVRLDAHCIPAPDYLERCVEALQAGKGENVGGVWQIQPSGEGWIARAIAAAAGHPLGVGDALYRFTSQPALVDTVPFGAFRRETLARVGFYDETLLTNEDYELNARIRKQGGKIYLDPAIRSIYFARNTLSALAKQYFRYGYWKWRMLRRYPETLRWRQALPPLFVLSLLVLLISGVFFRPLWLFLVAEIGVYLLALWLGALPVAWRKKDVWLGIGIPLAIMVMHVSWGSGFLWSMMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY81</accession>
    <name>E8MY81_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_22860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560679.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22860"/>
    <dbReference type="EnsemblBacteria" id="BAJ64312">
        <property type="protein sequence ID" value="BAJ64312"/>
        <property type="gene ID" value="ANT_22860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22860"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_1_0"/>
    <dbReference type="OMA" id="QEFCVCL"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="233"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="362" mass="41914" checksum="1FB660EBB1AF7516" modified="2011-04-05" version="1">MFSRSSSENSFPDDFQSLHEQWNRRRRLFYLLGSLAGIPSIVVVWLQHRLDNPFIAVTYPVLILSGILWSLALLWKRIPLHWVEKIVLFSISALFLGKLIYLLFFFGDLETAWKEVEAVYWVMALIFILSYIAMERKWALLFNLLVLAVTVGVGIFRFWGIAEPLLVEYIRLEARIATTSFLLFILARTKDEFIRTLTTAHAMHQMAYTDPLTFLPNRRWLTQTLEQRLSRKKRFTLILVDIDHFKQINDTFGHDTGDAVLREVSDCLHHQIRAGDVIGRWGGEEFLILASEEEAQSALQLAQRLRKALENFKLEVNLSVTASFGVTLSQEDDTIFSLLKRADLALYRAKSNGRNCVEWETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY96</accession>
    <name>E8MY96_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558439.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62041">
        <property type="protein sequence ID" value="BAJ62041"/>
        <property type="gene ID" value="ANT_00070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00070"/>
    <dbReference type="eggNOG" id="COG3602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113369_1_0_0"/>
    <dbReference type="OrthoDB" id="2008950at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018717">
        <property type="entry name" value="DUF2241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10000">
        <property type="entry name" value="ACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="ACT_7" evidence="2">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="140" mass="15842" checksum="3C8D600344A919FE" modified="2011-04-05" version="1">MLPSDDLSYLLAHMSPALHSRGYRFRSLPEEEALPWMTQSLGWFREEEGITLILPTPAGEEEWACITLSVYSSLTAVGFLALIARHLAEADIPLNVVSAVHHDHLFVPWERRTQALQVLENVIRQARHTSGEDCTHRPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD4</accession>
    <name>E8MYD4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
            <ecNumber evidence="2">1.20.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arsC</name>
        <name evidence="2" type="ordered locus">ANT_00450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.20.4.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558477.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62079">
        <property type="protein sequence ID" value="BAJ62079"/>
        <property type="gene ID" value="ANT_00450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00450"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_2_0"/>
    <dbReference type="OMA" id="DNAKERC"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="15233" checksum="2AB1C1807A6CE99A" modified="2011-04-05" version="1">MKKRVLVLCTGNSCRSQMAEALINHDLGERWQAFSAGTQPAGYVHPLALKALAEAGIVHEGESKSVEQFYGQDFDVVITVCDDAAENCPVWLGRGKRVHIGFPDPAKVEGTDEEKWRAFVQTRDAIRERVCGYLAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYG6</accession>
    <name>E8MYG6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_00770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558509.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00770"/>
    <dbReference type="EnsemblBacteria" id="BAJ62111">
        <property type="protein sequence ID" value="BAJ62111"/>
        <property type="gene ID" value="ANT_00770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00770"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253638_0_0_0"/>
    <dbReference type="OMA" id="SITTWRM"/>
    <dbReference type="OrthoDB" id="2885at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="SSF49410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="854"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="A2M_N_2" evidence="3">
        <location>
            <begin position="450"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="A2M" evidence="4">
        <location>
            <begin position="941"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="A2M_recep" evidence="5">
        <location>
            <begin position="1551"/>
            <end position="1646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1653" mass="180856" checksum="106C17FD4153D22C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYH0</accession>
    <name>E8MYH0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GGDEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_00810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558513.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00810"/>
    <dbReference type="EnsemblBacteria" id="BAJ62115">
        <property type="protein sequence ID" value="BAJ62115"/>
        <property type="gene ID" value="ANT_00810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00810"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_28_4_0"/>
    <dbReference type="OMA" id="RELHDQF"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225320" description="GGDEF domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="910"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1051" mass="117695" checksum="C0C52319E07D5B21" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK8</accession>
    <name>E8MYK8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">sbcD</name>
        <name evidence="8" type="ordered locus">ANT_23180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560711.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23180"/>
    <dbReference type="EnsemblBacteria" id="BAJ64344">
        <property type="protein sequence ID" value="BAJ64344"/>
        <property type="gene ID" value="ANT_23180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23180"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038682_0_0_0"/>
    <dbReference type="OMA" id="TSGNHDS"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="7">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="416" mass="47351" checksum="2475A90FF4251BB6" modified="2011-04-05" version="1">MKILHFSDAHIDIISQGKLDPSTGLPVRVLDFLKALDKIVDTAIEERVDLVLFTGDAYKDRTPVPTYQREWGKRIKRLSEAGILTVMITGNHDVSPALSRAHALQEYETLSIPHVRVCSRPQFLTPQDLEGLPLQIAALPWVPRSGFMIAQDNGLPEIDILNQKLEDAITQLITYWLENRIDSNLPVVFAAHASVEGAQYSSERSIMLGNEVSLSRGLVCDRRWTYVALGHIHKAQNLNEGNHPPVIYPGSIERVNIGEAREEKFFVLVHLDGKQVSHIEWKKLEGRRFIDRSVRVERQENFMETILREFPPQKDLEGAVFRLVVDYPAAWEKLLDEAALRRHAEGALEFMLVRRPQRELRVRLPEGVLASDMSPLQLLEMYLASIKVFPEEIQAIKSLAQEILWGGELEETKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK9</accession>
    <name>E8MYK9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560712.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64345">
        <property type="protein sequence ID" value="BAJ64345"/>
        <property type="gene ID" value="ANT_23190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23190"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051627_0_0_0"/>
    <dbReference type="OMA" id="GGMGHYR"/>
    <dbReference type="OrthoDB" id="1287580at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="114"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="434" mass="49363" checksum="525FD2135FB1B9D3" modified="2011-04-05" version="1">MRRFLKLLSGIIIVLLIGGLVSLAVPPVRERVFWHADQWRIRLQYALRPPEKEVFIPQEQPRLTPTALNTEDGAAPEPSATPLPTATLQPEVALDTPVPTPTPRVLPASVRLDGVKYFDQHGLWNYCAPANLAMALSFWGWNGDRTDVGKWVKPFEKDKNVMPYELADYVREQTQLSVIQRYGGTLETLKTLISGGFPVLIEKGAYMTDLSGKVSWMGHYAVVNGYDDAKGEFLTQDSYYEANYPIPYQELESQWRSFNFVFLVIYPPERENEVLELLGPLADEEQALRQALARASDELYRLDGIDQFFAWFNRGTSMVGLKDFLGASAAYDEAFRLYPSLPETRRPWRMLWYQTGPYFAYYYTGRYADLQSLATQTIESASEPYLEESFYWRAKAREALGDTEGAIQDLKTSLQYHPNFSPSVAALQNLGVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYL3</accession>
    <name>E8MYL3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative nickel insertion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LarC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560716.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64349">
        <property type="protein sequence ID" value="BAJ64349"/>
        <property type="gene ID" value="ANT_23230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23230"/>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028523_2_1_0"/>
    <dbReference type="OMA" id="TCLGLDW"/>
    <dbReference type="OrthoDB" id="1547060at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0533">Nickel</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="390" mass="42652" checksum="F1C6B9EF5605947F" modified="2011-04-05" version="1">MKIAYVDAFSGVSGDMLLGALLDAGISLERLTQALQSLHLPEEIHLNLTQVQKGAMRASQVQVQVPDSHHHRHLSDIEEILSQSTLPEIVLQNSLRVFRLLAEAEGRVHGISPDEVHFHEVGALDAIVDVVGVNLCLHELGIERLYASALPYGQGKITADHGVLPLPAPATLEILAQAHAPLLPVSSPFELVTPTGAALLAALATFEQPSICLECIGTGAGQRELPWPNILRVWIGSTPPREDLPLVLMETNIDDMNPQVLGSVMTQLLEAGALDVFFTPIYMKKNRPAVQVSLIARKSEEGVLAQLLLRHTTTLGLRVQPIYRYEAQREFHQVETPYGLIPLKVKLLDGKRVFAQPEYEACVQAAQTHQVPVMDVWQAALLAGQSLLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYL7</accession>
    <name>E8MYL7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560720.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23270"/>
    <dbReference type="EnsemblBacteria" id="BAJ64353">
        <property type="protein sequence ID" value="BAJ64353"/>
        <property type="gene ID" value="ANT_23270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23270"/>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1783759_0_0_0"/>
    <dbReference type="OMA" id="WGIAPIF"/>
    <dbReference type="OrthoDB" id="2061719at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="141" mass="14551" checksum="1957A7801853536D" modified="2011-04-05" version="1">MKPEIFALLTAILWGVGGFFEKKGLHLGNLPPTLGITIRTAVALLILGAASFPQWKLLPQAGTKALLYMVIGGGVVAGAAGMLCFYTALKGAPLTRVMPIAFTSPLFGALMGILFAGEPLTLKTILGMALTIGGIVLLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYT2</accession>
    <name>E8MYT2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64418">
        <property type="protein sequence ID" value="BAJ64418"/>
        <property type="gene ID" value="ANT_23920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23920"/>
    <dbReference type="HOGENOM" id="CLU_3021760_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="55" mass="6100" checksum="E75236E44762E43E" modified="2011-04-05" version="1">MMPYLLAAGSVILLLALLLIVSVIATVVMMGAFNLLRLIVLLRAGRQIILYRKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW4</accession>
    <name>E8MYW4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24240"/>
    <dbReference type="EnsemblBacteria" id="BAJ64450">
        <property type="protein sequence ID" value="BAJ64450"/>
        <property type="gene ID" value="ANT_24240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24240"/>
    <dbReference type="HOGENOM" id="CLU_1127257_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="29930" checksum="3F5574BE3F44EC24" modified="2011-04-05" version="1">MLEGMNRISRAKKASTLPRGHQWIAWRWNSQFWPRVIMAVKTLGETGVSTALDLLLLLSQKTGVEMRANSLRNVVYGALADEQVSHKMVDQFSVRLSGLGGFFTMNVLQLTDYGKDLCRALGVEPVESDWEKIIRLHRGEEQVVHGGAVLFAAYQARLRGWKAEVMPFDPQETPWFQPDLKVTDPEGWFYYCEVETRSRDNPDKWARMRQANLIVPTPTTRHWMVRRLKDMGIPGRATDLRTLAQQAKAGDLSRFWLEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-06-17" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW5</accession>
    <name>E8MYW5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560806.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24250"/>
    <dbReference type="EnsemblBacteria" id="BAJ64451">
        <property type="protein sequence ID" value="BAJ64451"/>
        <property type="gene ID" value="ANT_24250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24250"/>
    <dbReference type="HOGENOM" id="CLU_1329683_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="206" mass="23531" checksum="6996B93BE8125A51" modified="2011-04-05" version="1">MSAGLIVMHPQGMVIIADSRKMRGCEIVSDRSRKVFVFERVVVLHVGYAGLEGELEALMFRLEIRAKEWDAQSLAWKLLEEAEQIWGERLGKTEPVLFFVCDVVERVKRCYRVEVSQHERSVEGWTMKYERMVKTVAVGDETFQNLVMQTRLMEGAADLHEVVRRGRFAVEEAGRWVEMRDGWTSFGGECQTAVILNTGTVIYPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYY5</accession>
    <name>E8MYY5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560826.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64471">
        <property type="protein sequence ID" value="BAJ64471"/>
        <property type="gene ID" value="ANT_24450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24450"/>
    <dbReference type="HOGENOM" id="CLU_2950113_0_0_0"/>
    <dbReference type="OrthoDB" id="2189347at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="59" mass="6049" checksum="E7152BE36C79B4FB" modified="2011-04-05" version="1">MKIENLATVVIVIAGAVIGQAFLDRFPVLSQSPLIALAIGIGVSAVLGVVLSFLLKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ14</accession>
    <name>E8MZ14_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558555.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62157">
        <property type="protein sequence ID" value="BAJ62157"/>
        <property type="gene ID" value="ANT_01230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01230"/>
    <dbReference type="eggNOG" id="COG2188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063236_4_0_0"/>
    <dbReference type="OMA" id="GHIMSHT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="243" mass="27076" checksum="B034999BB953345A" modified="2011-04-05" version="1">MELNGKNTHPYQRLQDQLAQLIAATPPGGRLPAEPELARQLNVSRATLREAMRSFEGQGLIRRRQGVGTFVVGQPAVIETGLEVLESIETLAHRMGMDVSMGDLNIREVNANPEEAALFDVPQGTPLVQVRRTIHTAGRPVAYLVDILPEDVLTPQDLERGFTGSVLDLLLRRGSPMLTRSVAEIQAVAADAKVARWLEIQRGDVLLMFKARLYSAEERMIDLSYSFFLPGYFRFQVVRRVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ37</accession>
    <name>E8MZ37_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">era</name>
        <name evidence="12" type="ordered locus">ANT_01460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558578.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01460"/>
    <dbReference type="EnsemblBacteria" id="BAJ62180">
        <property type="protein sequence ID" value="BAJ62180"/>
        <property type="gene ID" value="ANT_01460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01460"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_0"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="212"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="308" mass="34569" checksum="210D4B0ADA1F29AD" modified="2011-04-05" version="1">MSEQIPAEFKSGFVAVVGRPNVGKSTLMNRFLGQKIAAVSPRPQTTRRRQLGILTLPQAQMVFVDTPGIHKPVHKLGEYMNQVALDALRDADVVLWLVDASVKPTDEDRLCAQRILEALGQNPANVLLALNKMDQVPEDQRAGRLKGYQDLLSSAWVVWISATSGAGTQDLLDEILRRLPEGPPYYEEEQITDLYEREIAADLIREAALIHLKDEVPHAIAVRIDEYKERSEDTAYIAATLLLERESHKPIVIGKGGEMLKRIGTTARLEIESMSGRKVFLDLRVKVMENWRDNPALLRSLGYVVRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ44</accession>
    <name>E8MZ44_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N_BRCA1_IG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62187">
        <property type="protein sequence ID" value="BAJ62187"/>
        <property type="gene ID" value="ANT_01530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01530"/>
    <dbReference type="HOGENOM" id="CLU_1615610_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="N_BRCA1_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228500" description="N_BRCA1_IG domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="N_BRCA1_IG" evidence="2">
        <location>
            <begin position="66"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="164" mass="17650" checksum="EC91F2835E1B1F7B" modified="2011-04-05" version="1">MSLALILLILAGCGGLPARGTPTLAPFRPAPPLPATPTPLTNPADLVLPLSTPVCLDNLTFLSDVTIPDGTEVEPNSTLDKRWEVQNSGNCNWDERYRLRLIAGPAMQAAEEQALFPARSGNKAIIQVVFQAPAEPGQYRSAWQAYNAEGQPFGDVIFIDIVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ51</accession>
    <name>E8MZ51_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62194">
        <property type="protein sequence ID" value="BAJ62194"/>
        <property type="gene ID" value="ANT_01600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01600"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070543_1_1_0"/>
    <dbReference type="OMA" id="GKGFWPT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022493">
        <property type="entry name" value="CHP03716_TM_YkoY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03716">
        <property type="entry name" value="R_switched_YkoY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="311" mass="33587" checksum="9E70143567C748F6" modified="2011-04-05" version="1">MSGVLSIATTTVRLPVGPASSGGSAEMDLSFLVIILQLIFLEGILSIDNAAVLGAMVSSLPDTQPIPWPPALKRVGHWLDGVLGPQRLAALRVGLLGAYVGRGLMLLAASFIIRNPWLKLVGAAYLIRLALDDLSAPGEQGAEEDGEVRPVRQAGFWLTVLNVELMDLAFSLDNVVAAVSLSDHILVVMLGVAIGILVMRFAAGIFSYVVEREPILKSAAYILVLSIGIELVLEELGIMEFSDWARFGISMSIIALSLAYAHLPFLRIFRPVLVWLSQGFGIINALIVWVLAPLRGLVYLVRLAFRRPEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ85</accession>
    <name>E8MZ85_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558626.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01940"/>
    <dbReference type="EnsemblBacteria" id="BAJ62228">
        <property type="protein sequence ID" value="BAJ62228"/>
        <property type="gene ID" value="ANT_01940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01940"/>
    <dbReference type="HOGENOM" id="CLU_1792456_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="144" mass="16003" checksum="A6D128B3FEDF89F6" modified="2011-04-05" version="1">MNPLSRIRAPADQPLQDGYTRTLEALRHEERLLAVCLPLLLLAVLVLFIPAVGGLGSPPLRPLLTAINLTGILLTLLTLWLARNLLERIRARVEACREMETRLCLPALQESSVLDTHPLNLLFSALIILLLGGWILHLIVVWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE6</accession>
    <name>E8MZE6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative kanamycin nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">knt</name>
        <name evidence="2" type="ordered locus">ANT_24680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560849.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24680"/>
    <dbReference type="EnsemblBacteria" id="BAJ64494">
        <property type="protein sequence ID" value="BAJ64494"/>
        <property type="gene ID" value="ANT_24680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24680"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105081_0_0_0"/>
    <dbReference type="OMA" id="DIEMFCV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012481">
        <property type="entry name" value="KNTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07827">
        <property type="entry name" value="KNTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KNTase_C" evidence="1">
        <location>
            <begin position="113"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="256" mass="28937" checksum="76F9662365235F0E" modified="2011-04-05" version="1">MGGPQPFSHEIRITRAQDIAQRIQRHFGKRTLAIGLYGSLARQSDGPFSDIEMHVLIENMEGDHTLEWSEGPWKAEVNLYSPQTFLEQASELESDWPITHGAYANILPVLGDSGWFSQARERVFNHDEDEIRPVLEEALIGDLYEIIGKLRNARSSGNTQSVATYAFYAARFAVCIVGLWHRHLYTGSAILYKEALSLPDRPKGFDPFIQRIMEGNLTDPQTVFEEADALWAGFEGWADAHGLTLYRSLDDLLNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZL8</accession>
    <name>E8MZL8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560921.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25400"/>
    <dbReference type="EnsemblBacteria" id="BAJ64566">
        <property type="protein sequence ID" value="BAJ64566"/>
        <property type="gene ID" value="ANT_25400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25400"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952012_0_0_0"/>
    <dbReference type="OrthoDB" id="1850505at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="102"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="292" mass="33344" checksum="FEEACC33C355F3A9" modified="2011-04-05" version="1">MESEVTTQGVESKPQIQPKQHFRAKVLKISLAGAAVDLGIGQPAFLHISQIQPLDDEPIKRVSDVLQEGQEIDVWVKRVKEGRIEVTTFKPLDLEWRDLKKGMVVKGTVVRLEKFGAFVEIGAERPGLLHISEMAHGYVREPSEVVKEGDEIEVEVIDFNRKKRQIKLSRKALLPEPVKEEEPIQAFIEPPKRERPKDREKDKEKDKEKAQRRKKAKAPRTREEDTISVDALLESLGEEPQPEVETAMAIAWREAMERAKARKAEEKGRKKATSQEQEEILARTLENKVQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR9</accession>
    <name>E8MZR9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">murJ</name>
        <name evidence="10" type="ordered locus">ANT_25910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560972.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25910"/>
    <dbReference type="EnsemblBacteria" id="BAJ64617">
        <property type="protein sequence ID" value="BAJ64617"/>
        <property type="gene ID" value="ANT_25910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25910"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_5_2_0"/>
    <dbReference type="OMA" id="IFFVAFK"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="526" mass="56148" checksum="F6439AB2EED0184D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT2</accession>
    <name>E8MZT2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560985.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26040"/>
    <dbReference type="EnsemblBacteria" id="BAJ64630">
        <property type="protein sequence ID" value="BAJ64630"/>
        <property type="gene ID" value="ANT_26040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26040"/>
    <dbReference type="eggNOG" id="COG5433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1253794_0_0_0"/>
    <dbReference type="OrthoDB" id="714984at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032806">
        <property type="entry name" value="YbfD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13808">
        <property type="entry name" value="DDE_Tnp_1_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1_assoc" evidence="1">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="220" mass="24551" checksum="516AD3A9D8C1863D" modified="2011-04-05" version="1">MKCNIEAGIVFDVGSLYAHFQRLQDTRKPKGIRYPLALVLLLIVLAKICGEDRPSGIAECAKHRTEMLVEWLKLKRNSLPHHSTYRRILAEVVNVEELEHIQHIYLSGEKSFGTQVLVSIDGTVLRGTLDNQQQGTYLLAAYLPAEGIVLMEVAIEGKGGEIPAAPRVLNRLDLREKVVIGDALHTQKELSRQIVAAGGGLYLVCERQSGTDRRRYPFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV3</accession>
    <name>E8MZV3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA polymerase III delta' subunit</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">holB</name>
        <name evidence="4" type="ordered locus">ANT_02540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558685.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02540"/>
    <dbReference type="EnsemblBacteria" id="BAJ62288">
        <property type="protein sequence ID" value="BAJ62288"/>
        <property type="gene ID" value="ANT_02540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02540"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_0_0"/>
    <dbReference type="OMA" id="DIQHAAS"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="341" mass="38253" checksum="EC46A7D249370CA1" modified="2011-04-05" version="1">MTWEISGHDWAVDLLKGHIQRGEVRHAYLFSGAAGIGKRTLALRFAQALNCPTPLAPGEPCRTCRVCRQIEQMSHVDLSVVQSEGEGMVLKVDQARELQQTLALLPRELPYRVALLLRFHEANASAQNALLKTLEEPPARAILLITATSPEELLPTIVSRCEVLRLRPLAPEACAQVLIKRGVPAEEAQWLAHLSGGRPGYALNLHAQPDLLEARRRTLEDLLHLLGAPRRERFAYAERLTASRGKERERLLQTLPLWLSFWRDVMICASGSGLSLTHLDFAEQIQRVAEQVGLARAAFVTRRLEEHLQRLESNPNMRLLVEMSLLEMPRLAEEVSAAPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX6</accession>
    <name>E8MZX6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558708.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02770"/>
    <dbReference type="EnsemblBacteria" id="BAJ62311">
        <property type="protein sequence ID" value="BAJ62311"/>
        <property type="gene ID" value="ANT_02770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02770"/>
    <dbReference type="eggNOG" id="ENOG502Z7KY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124273_0_0_0"/>
    <dbReference type="OMA" id="FCDRRYD"/>
    <dbReference type="OrthoDB" id="1197155at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025352">
        <property type="entry name" value="DUF4256"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14066">
        <property type="entry name" value="DUF4256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="188" mass="21575" checksum="0B75F1AA5F1D26D5" modified="2011-04-05" version="1">MTHTSQPLSTEQRETLLKTLKERFAKHMHRHPGLDWEAVQARIETYPEKVWSLYEMERTGGEPDVIGVDETTGEILFCDCSPESPAGRRSLCYDRAAWEARKENKPAGSVMEMAEAMGIELLTKEQYRALQRLGEFDTKTSSWVKTPTSIRQLGGALFCDRRYNTVFVYHNSADSYYASRGFRGLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX7</accession>
    <name>E8MZX7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">maf</name>
        <name evidence="3" type="ordered locus">ANT_02780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558709.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02780"/>
    <dbReference type="EnsemblBacteria" id="BAJ62312">
        <property type="protein sequence ID" value="BAJ62312"/>
        <property type="gene ID" value="ANT_02780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02780"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_0_0"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="228" mass="24650" checksum="CD8424ED3E178EDD" modified="2011-04-05" version="1">MQKPVLILASNSPRRRQLLGLTGREFLVRPSDVDETPLPGETPDAYVLRLAEDKARATAEHAPAEAWVIASDTTVALEGRILGKPEDAAEARAMLTALRDRMHDVYTAVALFHPASGQMLSEVCHTGVHMRAYTDEEIEAYIATGDPMDKAGAYGIQHAGFSCVDALDGCYASVMGLPLCHLERLMRGVGLAAEVDVPEVCQRFLAYDCPVFSSILQDSASGREAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N003</accession>
    <name>E8N003_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_03040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558735.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03040"/>
    <dbReference type="REBASE" id="32159">
        <property type="entry name" value="M.AthUNI1ORF3040P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62338">
        <property type="protein sequence ID" value="BAJ62338"/>
        <property type="gene ID" value="ANT_03040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03040"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_2_0"/>
    <dbReference type="OMA" id="FKRDIIW"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="304" mass="35396" checksum="5637A8EB6664D388" modified="2011-04-05" version="1">MNIIYTHSCERMPELEEGAVSLTVTSPPYWNAIDYDRHAEDDSQYYRTRQYANGYQDYHEYLDWLVRIFREVYRVTKPGGFCAVVIGTVLLEGKLYPVPFDMTSQFVQIGWEFYQDIIWHKCTAGVKRAGVSIQKPYPGYFYPNIMNEYILIFRKPGPRIYENRSQEEKEQAQYSIDRLFTMDIANNIWHIAPVPPKIIPHPAPFPEEIPFRLIQLYSYPGDLILDPFVGSGQTLKVARHLGRPYVGYEVIEKYVQLAKQRIPEPLDLRQEQLIAVFDKVSIGEPIKGKANGKVHQPSLLKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J5</accession>
    <name>E8N0J5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561096.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27180"/>
    <dbReference type="EnsemblBacteria" id="BAJ64744">
        <property type="protein sequence ID" value="BAJ64744"/>
        <property type="gene ID" value="ANT_27180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27180"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028098_0_0_0"/>
    <dbReference type="OMA" id="NERATRW"/>
    <dbReference type="OrthoDB" id="2011619at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="579" mass="62665" checksum="DF6DAD021B728D97" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0L3</accession>
    <name>E8N0L3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04870</name>
        <name evidence="2" type="ordered locus">ANT_27360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="2">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558917.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04870"/>
    <dbReference type="EnsemblBacteria" id="BAJ62521">
        <property type="protein sequence ID" value="BAJ62521"/>
        <property type="gene ID" value="ANT_04870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64762">
        <property type="protein sequence ID" value="BAJ64762"/>
        <property type="gene ID" value="ANT_27360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04870"/>
    <dbReference type="KEGG" id="atm:ANT_27360"/>
    <dbReference type="HOGENOM" id="CLU_942144_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="33490" checksum="A98AB14E9EDD16EF" modified="2011-04-05" version="1">MSDKRYFWIGTLLLFGVLVFLVQQEIVRASALEKDQARDFVQYTLVEHIIPDDVDLSVDWTRESPTVDRQELAKALERIEAIPSFHGPGWVHRVYVGYQVPPDPPHPLHPKDGYHVLEEWLYVNKVGVVEKILQTSADLQGNLLQEIACAEEICGNLSKAGLVEFKDEPLTQPFQPYRFNQNEAPALLQELYASNKETWGWMEEREMGKTLFVASYGKNTAEQISQIPGFEGTLIQYGILVDSGVLAHFSLYEKRDGAFVLNSTDDLVLFETLPSNPEIERRIASAVKILKEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0M3</accession>
    <name>E8N0M3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rplI</name>
        <name evidence="10" type="ordered locus">ANT_03840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558814.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03840"/>
    <dbReference type="EnsemblBacteria" id="BAJ62418">
        <property type="protein sequence ID" value="BAJ62418"/>
        <property type="gene ID" value="ANT_03840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03840"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_3_0_0"/>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="166" mass="18091" checksum="AEEF43AF934ED39A" modified="2011-04-05" version="1">MKVLLIKDVYKLGRAGDVKKVADGYGRNYLIPQGLAVLATPGALKMAESIRARAAKQREALNQEMSGLAQRIQGQYLTFAARAGETGKLYGSITPTMIAEALSRKLGVTIDRHQIEAQSIRNLGEFKAHVRLTVDLVPEINIIVHREGETPNVPVEETQTGEGEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R0</accession>
    <name>E8N0R0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_04210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558851.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62455">
        <property type="protein sequence ID" value="BAJ62455"/>
        <property type="gene ID" value="ANT_04210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04210"/>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061158_0_0_0"/>
    <dbReference type="OMA" id="YPMIGSH"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="42"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="320" mass="36151" checksum="D6A818F96FFFEA5A" modified="2011-04-05" version="1">MFRAFFVSLSRATWAQKWITRLPVARQAAARFVAGETQAEALQAVRQLNQRGILATLDHLGESTTRASDAQQATAEILSLLDAIQQAGVQANVSIKLSQIGLAVDPALCEANLWKILEKARDLGNFVRIDMEDSSLTQRTLDLYLKALVSGFADHVGIVLQAYLYRTEADLTRVLTAGGRVRLCKGAYKEPSTLAFSRKADVNLNYDQLALQMLRHTLRHGTPQVSADGRTPPIPALATHDPQRIRFARQAVEELYLPKRAVEFQMLYGIRRDLQESLAAEGFPVRVYVPYGTHWYPYFMRRLGERPANLWFFVKNFFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z5</accession>
    <name>E8N0Z5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11 12">Xylose isomerase</fullName>
            <ecNumber evidence="4 11 12">5.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">xylA</name>
        <name evidence="15" type="ordered locus">ANT_05060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>alpha-D-xylose = alpha-D-xylulofuranose</text>
            <dbReference type="Rhea" id="RHEA:22816"/>
            <dbReference type="ChEBI" id="CHEBI:28518"/>
            <dbReference type="ChEBI" id="CHEBI:188998"/>
            <dbReference type="EC" id="5.3.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11 13">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the xylose isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.5" evidence="4 11 12"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558936.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05060"/>
    <dbReference type="EnsemblBacteria" id="BAJ62540">
        <property type="protein sequence ID" value="BAJ62540"/>
        <property type="gene ID" value="ANT_05060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05060"/>
    <dbReference type="eggNOG" id="COG2115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060750_0_0_0"/>
    <dbReference type="OMA" id="HKFTFGL"/>
    <dbReference type="OrthoDB" id="481478at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009045">
        <property type="term" value="F:xylose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00455">
        <property type="entry name" value="Xylose_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013453">
        <property type="entry name" value="XylA_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001998">
        <property type="entry name" value="Xylose_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00688">
        <property type="entry name" value="XYLOSISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02631">
        <property type="entry name" value="xylA_Arthro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51415">
        <property type="entry name" value="XYLOSE_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="14">
        <location>
            <begin position="42"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ62540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="388" mass="43515" checksum="F08F4D2D7E17D350" modified="2011-04-05" version="1">MSDYTPKPEHKFTFGLWTVGSTGRDPFGAPTRDALSPVELVHLLAEVGAYGVNFHDNDLVPIDATPAERDRIVRDFKNALKETGLVVPMATTNLFSDPVFKDGAFTSNDPKVRAYALQKTMQAIDLGVELGAKVYVFWGGREGTESDATKNPVDAIKRTREALNFLCEYVLDQGYDLKFALEAKPNEPRGDIYNPTTGHMLAFIETLDHPEMVGVNPEVAHEHMAGLNFLHGVAQAWEAGKLFHIDLNDQYPGRYDQDFRFGSRDLKAAFFLVKFLEDVGYSGSRHFDAHAYRTEDYEGVKDFARGCMRTYLILKEKAARFNADPEIQALLAEINATEPSLESVFGAYSREKANRLKGMTFDRVSLGKRGLKYERLDQLTIDLLLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N101</accession>
    <name>E8N101_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558942.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05120"/>
    <dbReference type="EnsemblBacteria" id="BAJ62546">
        <property type="protein sequence ID" value="BAJ62546"/>
        <property type="gene ID" value="ANT_05120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05120"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_300477_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="699"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="996" mass="113521" checksum="AD67E15224AD2F0C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N109</accession>
    <name>E8N109_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558950.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05200"/>
    <dbReference type="EnsemblBacteria" id="BAJ62554">
        <property type="protein sequence ID" value="BAJ62554"/>
        <property type="gene ID" value="ANT_05200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05200"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_487157_0_0_0"/>
    <dbReference type="OMA" id="KVRYAYY"/>
    <dbReference type="OrthoDB" id="256283at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="567" mass="64225" checksum="2A0663E5078EC4A3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N115</accession>
    <name>E8N115_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62560">
        <property type="protein sequence ID" value="BAJ62560"/>
        <property type="gene ID" value="ANT_05260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05260"/>
    <dbReference type="HOGENOM" id="CLU_1575259_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="169" mass="18449" checksum="1B108476CC130709" modified="2011-04-05" version="1">MSMWKAVTLRLIFSLILGMLAGWAVSEISYQLLKDPNARDQARRIELVIPPGTAERVAAGEPVLSLPEKMTFVEGDLLVVKNLDSVSHQLGPVWVPPQSSGVLEVGKASTYQYTCTFQTSRLFGIEVKPNLTVETRIQGVLLMGLPSAAMLGLYSFLIFPIRAKEGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N132</accession>
    <name>E8N132_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_27490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561123.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27490"/>
    <dbReference type="EnsemblBacteria" id="BAJ64775">
        <property type="protein sequence ID" value="BAJ64775"/>
        <property type="gene ID" value="ANT_27490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27490"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_0"/>
    <dbReference type="OMA" id="WTAKKEY"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="129"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="255"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="331"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="416"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="558"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="820" mass="93440" checksum="A6F8AD06AAC884C8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N162</accession>
    <name>E8N162_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561153.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27790"/>
    <dbReference type="EnsemblBacteria" id="BAJ64805">
        <property type="protein sequence ID" value="BAJ64805"/>
        <property type="gene ID" value="ANT_27790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27790"/>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942146_0_0_0"/>
    <dbReference type="OMA" id="MECTVCH"/>
    <dbReference type="OrthoDB" id="1594479at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="33840" checksum="F4D38BEC259437FF" modified="2011-04-05" version="1">MKSIPVCDYEGSDYQTSFWEQGARRYEDAVEAVALRRLLPAGGKRLLELGAGAGRNTPRYQGFEEITLVDYSHTQLQQARQRLGDSPRYRYVAADIYYLPFSAGVFDAATMIRTLHHMVEPRLALEQVRRTLQRDAVFILEYANKQNLKAILRYLLRRQSWNPFSPEPVEFAPLNFDFHPATVREWLKVSGFVIERQLTVSHFRVDLLKRLLPLSLLVAMDSLAQWTGNLWQLTPSVFARCRAVGTFATGQGFFRCPACGQEGLADTPPEILCPSCGQRYPVRDGIYDFRLEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N186</accession>
    <name>E8N186_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561176.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28030"/>
    <dbReference type="EnsemblBacteria" id="BAJ64829">
        <property type="protein sequence ID" value="BAJ64829"/>
        <property type="gene ID" value="ANT_28030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28030"/>
    <dbReference type="HOGENOM" id="CLU_1056209_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010368">
        <property type="entry name" value="Com_YlbF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06133">
        <property type="entry name" value="Com_YlbF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="SSF158622"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="263" mass="29520" checksum="7C15998A3B82DF43" modified="2011-04-05" version="1">MSLSAFVPAILQQPDKEPIRHATLNLAEALAESEEFQRFLESAQTVHGNAEVHRLLVAIRQGRTRYDQGEAPSLQSQVEALPVMRAYRRAEQAVRFLFSAVVQEISRSAGVDFLEHVHQEMNACGMPVHVVSDEVLNLPETLPEPYAEPARRLGEALHNSPEVQAYLAVQRAVREDIALANLRREVEEMEESFNVRRASGYYPASGELELYAEKQAELRQHPLLRAEEDARAQVMELFSAVHTLLSNSLGILFSELAKKPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N199</accession>
    <name>E8N199_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_28160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561188.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28160"/>
    <dbReference type="EnsemblBacteria" id="BAJ64842">
        <property type="protein sequence ID" value="BAJ64842"/>
        <property type="gene ID" value="ANT_28160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28160"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_4_0_0"/>
    <dbReference type="OMA" id="IHCGDFV"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="166" mass="17826" checksum="9426887CC1B6E04F" modified="2011-04-05" version="1">MKLGVLSDTHNNLTALEQALALFRQEKVDWLIHCGDITTPETASAMGEFPVWHAVGNGDFASGEIRAVFQRFNPLNQSALVVTGVLGGISIAVTHGHLPGKVTELVQSGQYAYVFYGHSHRRKAQKVGNTWLINPGALGGLRPEAPSVYLIDLESGDSGFFLVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A4</accession>
    <name>E8N1A4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561193.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64847">
        <property type="protein sequence ID" value="BAJ64847"/>
        <property type="gene ID" value="ANT_28210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28210"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_3_0"/>
    <dbReference type="OMA" id="HATRFAN"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="15"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="543" mass="62951" checksum="FEFAC337EFC1F3C7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1B3</accession>
    <name>E8N1B3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64856">
        <property type="protein sequence ID" value="BAJ64856"/>
        <property type="gene ID" value="ANT_28300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28300"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_4_0"/>
    <dbReference type="OMA" id="ADNILCH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="174"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="304" mass="34246" checksum="815F9A7066D9E37A" modified="2011-04-05" version="1">MQGNEKMSEDLYLELLDNLFDGVYYVDRNRVITFWNKASERLTGYGKDEVLGKACSDNILKHIDSHGRELCVQGCPLHATMADGKMREALLYLHHKDGHRVPVHIRVSPLMDEQGNVIGGIEVFSDGTQSLQTLQELEHLKNEIFIDPLLKIGNRRYAEMIFQTRLYELNAFNVPCGVVFLDVDNFKEINDTFGHLIGDRVLLMVSRSIASALRGTDTLIRWGGDEMLIFLPNVTPAGLKTIAERIRVFVEKSFLMVGDQKITVTVSVGATLLDKEDTLESITQRTDSLLYQSKQSGKNQITVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C6</accession>
    <name>E8N1C6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_28430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28430"/>
    <dbReference type="EnsemblBacteria" id="BAJ64869">
        <property type="protein sequence ID" value="BAJ64869"/>
        <property type="gene ID" value="ANT_28430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28430"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009347_1_0_0"/>
    <dbReference type="OMA" id="IWITTQL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="11">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="275"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="491"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="793" mass="90270" checksum="CE1F12F179275218" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1D6</accession>
    <name>E8N1D6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GGDEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561224.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64879">
        <property type="protein sequence ID" value="BAJ64879"/>
        <property type="gene ID" value="ANT_28530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28530"/>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012640_1_0_0"/>
    <dbReference type="OMA" id="EFYAAWV"/>
    <dbReference type="OrthoDB" id="1599626at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038242">
        <property type="entry name" value="Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024615">
        <property type="entry name" value="CRISPR-assoc_Cmr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013407">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040942">
        <property type="entry name" value="Minimal_Cpol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12469">
        <property type="entry name" value="DUF3692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18182">
        <property type="entry name" value="mCpol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02577">
        <property type="entry name" value="cas_TM1794_Cmr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="323"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="586" mass="66469" checksum="14F4A6D746597306" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1L2</accession>
    <name>E8N1L2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative methylmalonyl-CoA decarboxylase beta-subunit</fullName>
            <ecNumber evidence="9">4.1.1.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mmdB</name>
        <name evidence="9" type="ordered locus">ANT_05830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.1.1.41" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559012.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05830"/>
    <dbReference type="EnsemblBacteria" id="BAJ62617">
        <property type="protein sequence ID" value="BAJ62617"/>
        <property type="gene ID" value="ANT_05830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05830"/>
    <dbReference type="eggNOG" id="COG1883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036168_0_0_0"/>
    <dbReference type="OMA" id="VGAMIDF"/>
    <dbReference type="OrthoDB" id="662061at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="374" mass="39647" checksum="55AA4E02B9AE6B0B" modified="2011-04-05" version="1">MDLSNLSILLQAFRELGWQNIVMLGVGGFLIFLAVKYEFEPNLLLPIGFGAILGNLPLTGVTEQGGFLKIIYDFGISTELFPLFIFIAIGAMTDFGPLLENPRMALLGAAGQLGIFTTLLLALAIGFPLKEAASIGIIGAIDGPTAIYVSSKLAPHLLPAITVTAYSYMSLVPIIQPPVMRLLTTKAERRVRMPYTIKPVSRVVRVLFPIVVTILVSLIAPKASPLISSLMFGNLIRESGVVERLSKGAQNELANLVTLFLGLVIGSTMEGKAFIQPQTLAILGLGLLAFVLDTVGGVLFGKLMYVLSGKKFNPCIGAAGISAFPMSARIVQRFVSEEDFQNFVLMHAMGANAAGQLGSVVAGGVVLAVLAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R1</accession>
    <name>E8N1R1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Capsule polysaccharide biosynthesis family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559061.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06320"/>
    <dbReference type="EnsemblBacteria" id="BAJ62666">
        <property type="protein sequence ID" value="BAJ62666"/>
        <property type="gene ID" value="ANT_06320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06320"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505927_0_0_0"/>
    <dbReference type="OrthoDB" id="545462at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015774">
        <property type="term" value="P:polysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007833">
        <property type="entry name" value="Capsule_polysaccharide_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05159">
        <property type="entry name" value="Capsule_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="538" mass="62192" checksum="A37E5A258EB44757" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S9</accession>
    <name>E8N1S9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative oxidoreductase</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_06500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559079.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06500"/>
    <dbReference type="EnsemblBacteria" id="BAJ62684">
        <property type="protein sequence ID" value="BAJ62684"/>
        <property type="gene ID" value="ANT_06500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06500"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_0"/>
    <dbReference type="OMA" id="GWHPTQM"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="34"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="113"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="322" mass="35678" checksum="CAAB26586DFD5290" modified="2011-04-05" version="1">MPTVLLSAPYMIPVVDRFRPVFAHYGLEIIVPPVRERLEEAELLEYAGQFDGAICGDDRFTARVIERCLPRLKVISKWGTGIDSIDHQAAQRLGVQVRNTPNAFTLPVSDSVMGYILAFARQIPWMDRAVKSGVWAKLPGYSLSERTLGVVGVGNIGKAVIRRARAFGMKILGNDIVPIAPDFILENGVEMTSLHDLLERSDFVSLNADLNPTSYHLINAETLAHMKPTAVLINTARGPLVDEPALIRALEEKRIAGAALDVFEIEPLPEDSPLRRMENVLLAAHNSNSSPAAWERVHWNTIRNLLDGLGIPHEDLAQWMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T4</accession>
    <name>E8N1T4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_06550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559084.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06550"/>
    <dbReference type="EnsemblBacteria" id="BAJ62689">
        <property type="protein sequence ID" value="BAJ62689"/>
        <property type="gene ID" value="ANT_06550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06550"/>
    <dbReference type="eggNOG" id="COG5305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_544747_0_0_0"/>
    <dbReference type="OrthoDB" id="2028490at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="80"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="500" mass="55414" checksum="E855C7DD33C178F0" modified="2011-04-05" version="1">MTLRGNAVGQELRSVFSLVPFSRGERWFLLFVTLSGMLARLPLLSRPMVHDEAYTYVAFASRPLLAVISDYHLPNNHIFHTLLVHLVTAWLGAHPWTVRLPAFLAAALCIPALALLGARLYSPRAGLLAATLLAGLPVQALYATNARGYSLYTFFTLALFLLAQVLAHRPSVSLWALVAIVAGLGFWTVPFMVYPFAGVMLWLAMTLWDGENRSFARWMKKVALPFLGVTLGVGLLVVLVYLPVVLWGTGWRSLAGNGFVQPLEWGALFPTALMRLRETADEWTLGLPAWAGWGISAGALMAMLLHSRFSRERFSPLLMAVIGAFGVWLIQRGNPMARLWTYLIPLWVLGGAVGLWQLWAFLRQRLLWLSRFEGAGAVVLLVVLSVSSLRAFSLHAGEVQQVADLLVKEGSTQFFAAAGTPDDAPLWFYLMEAGAGRETFERKRMNSPESIFVVVRPSEEQTPQSVLAERGLDESLCAPQTLHLWQVVGGLQVYRCERQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1U3</accession>
    <name>E8N1U3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559093.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06640"/>
    <dbReference type="EnsemblBacteria" id="BAJ62698">
        <property type="protein sequence ID" value="BAJ62698"/>
        <property type="gene ID" value="ANT_06640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06640"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="CRFKDRC"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="336" mass="37565" checksum="7E792D0E87275033" modified="2011-04-05" version="1">MGKVILDVRELSTKYVTRFGESVYAVDRVSLKVEEGKSLGIAGESGCGKSTLALSLMGYYFAPLHYISGDIIIDGVNISKMHPDEVRRKILGKEIAYIPQAAMNALNPTLKIINFIEDVIHAHDPKVPKKQIYEMARQRFEELGLPAEVLQKYPVELSGGMKQRTVIATSVILSPKVLIADEPSSALDVTSQKMVIKMLRDMMERGLVKAMIFITHELPLLYNVTDDIMVMYAGQIVEQGTAQQVVFDPLHPYSKGLMGSIIVPESGVRDVKLTAIPGAPPNLKRPPQGCRFADRCKYVQAECRVQSIYMREAANNRAYRCIYPEEQLRKVYENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z2</accession>
    <name>E8N1Z2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561283.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29130"/>
    <dbReference type="EnsemblBacteria" id="BAJ64939">
        <property type="protein sequence ID" value="BAJ64939"/>
        <property type="gene ID" value="ANT_29130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29130"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1140919_0_0_0"/>
    <dbReference type="OMA" id="WRTESSK"/>
    <dbReference type="OrthoDB" id="1797561at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="254" mass="27365" checksum="91B01718BF9BE964" modified="2011-04-05" version="1">MRLNSFALAALIVTLIFGGIAFSTAMNWWQTETTREVAVFTEGEFAGLPNPADIRGSYTFGDVVNNFEVSLSDLAIAFRLPADVDAASFKVKDLESLYEDLPVEVGTASVRMFVAFYLGLPYDLSASEDTYLFPEAAAILQARGNMLPEQAAFLESHIVPETAAETVESAPESPATSVTPTPAPTEHVAPERTVTGKTTFQELLNWGVTQETIESLLGGAMPAPATSIKDYAVSKGLEFSSLKTKLQEAVEQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N295</accession>
    <name>E8N295_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">8-amino-7-ketopelargonate synthase</fullName>
            <ecNumber evidence="7">2.3.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bioF</name>
        <name evidence="9" type="ordered locus">ANT_30160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561383.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30160"/>
    <dbReference type="EnsemblBacteria" id="BAJ65042">
        <property type="protein sequence ID" value="BAJ65042"/>
        <property type="gene ID" value="ANT_30160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30160"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_0"/>
    <dbReference type="OMA" id="PFFRVHE"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010962">
        <property type="entry name" value="AONS_Archaea/Firmicutes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01825">
        <property type="entry name" value="gly_Cac_T_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="8">
        <location>
            <begin position="41"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604723-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ65042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="394" mass="42877" checksum="0C283EB750A04697" modified="2011-04-05" version="1">MSERLQWIQDELDRLKESGLYNRIRTISTPQGAWLVVDGKRVLNFCSNNYLGFANHPRLVEKARQALEKYGVGPGAVRTIAGTLDLHTELERRIAAFKGVDAAITFQSGFTANLATIAALVGKEDVVFSDELNHASIIDGCRLSGARIVRYAHADPVDLEARIRENEGTYRRAIAITDGVFSMDGDIAPLDKIYEVTSAYNVMLMVDDAHGEGVLGKGGRGIVDHFNLHGKVDIEIGTFSKAFGVVGGVSAGSPLVVEWLRQRGRPFLFSSATPAADVAACIAAIDVLEESTELVDRLWENARYFKAEMKKLGFDTGVSVTPITPIMLGEAPLAQQFSRELFEEGVFAMAIGYPTVPHGKARIRVMISAAHSKDDLDKGLEAFARVGKRLGVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2C5</accession>
    <name>E8N2C5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559125.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06970"/>
    <dbReference type="EnsemblBacteria" id="BAJ62731">
        <property type="protein sequence ID" value="BAJ62731"/>
        <property type="gene ID" value="ANT_06970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06970"/>
    <dbReference type="eggNOG" id="ENOG502ZDQC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_433276_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="571" mass="64544" checksum="925F57171B55EDE0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2E6</accession>
    <name>E8N2E6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein EutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eutA</name>
        <name evidence="1" type="ordered locus">ANT_07180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559145.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62752">
        <property type="protein sequence ID" value="BAJ62752"/>
        <property type="gene ID" value="ANT_07180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07180"/>
    <dbReference type="eggNOG" id="COG4819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046255_0_0_0"/>
    <dbReference type="OMA" id="NCDYIDI"/>
    <dbReference type="OrthoDB" id="845924at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009377">
        <property type="entry name" value="EutA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06277">
        <property type="entry name" value="EutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012293">
        <property type="entry name" value="EutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="482" mass="51914" checksum="26C6DCEEBDD2BDCA" modified="2011-04-05" version="1">MSDTREMLSVGIDVGTTTTQLVFSRLSVKSVSRPGQVPRFQVSAKSAVYESPAYFTPLLSPDLVDVQKLTEIIRSEYQKAGVQPQQVETGAVIITGEIARTQNAEEILKGIASLAGDFVVTVAGPNVESLIAGRGSGAAAYSAENYTTVTNVDIGGGTSNAAIFRLGEHLSSSAMAVGGRQIVIEKTSGIVQHIAPPGQRIINALGLPIFVGKRVDVEIIKPFCDCMADLVADLIQGIESDLGKELQLSPPLIHAEESKILFISGGVGTYFYHPVDIRSLADVTIHNDVGPLLAQSLRMNPRIRKMRIEVPAETLRATVLGAASQTVTLSGSTIFTDAKLLPMRNLPVIRPALEERDLHDPAKIAEAIRNATRRWDLKQNAGTFALALNLPARLDFPTLQSIAQGVVQFAREELKQDDPLVIVGEADYAQVLGQTIRAIHPQIPLISVDQINLAEGDFIDIGEPILDGRVVPLSVKTLIFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I7</accession>
    <name>E8N2I7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_07590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559186.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62793">
        <property type="protein sequence ID" value="BAJ62793"/>
        <property type="gene ID" value="ANT_07590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07590"/>
    <dbReference type="eggNOG" id="COG4986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036171_2_0_0"/>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="OrthoDB" id="1065003at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="369"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="574" mass="63999" checksum="D0A725B3DEC7B49A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N302</accession>
    <name>E8N302_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphotransferase</fullName>
            <ecNumber evidence="9">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_31260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561493.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31260"/>
    <dbReference type="EnsemblBacteria" id="BAJ65152">
        <property type="protein sequence ID" value="BAJ65152"/>
        <property type="gene ID" value="ANT_31260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31260"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_0"/>
    <dbReference type="OMA" id="RGHVREK"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="175"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="279"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="428"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ65152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="486" mass="53316" checksum="2B39280603DB66ED" modified="2011-04-05" version="1">MPIHFGTDGWRAVISDTFTFTNLRMVAQAIADSIASGSWTDSLPTDRPIDPKRMVVGFDTRFLSDRFAQEVARVLAANDFTVYLAQADAPTPAISYAVYHRNAIGGVMITASHNAPRYNGVKLKSYYGGSALPDQCREVEVFLNDNEAKARGPNLMEYEHALEEKRIIRFNPIPEYYDHLRRLIDFDVIASNPPRFVVDSMYGSGRGVIRGILQGTGCEVTEIRGEMNPGFGGVHPEPIARYLGALAGAIGSGVGGFGIATDGDADRTGAMDEHGNFVDPHKIMALSLRYLVEKRGMRGAVVRTVSTTRMIDRLCQKYNLPLYETPVGFNHIADYMMKDEVLIGGEESGGISFKGHIPEGDGILMGLLIVEMVAAYRTTLRDLVEQLLAEVGPAHYERTDLRLRRPVSKSQMTARLVNEAPAEIGGERIVDVSTLDGVKYILADDSWLLIRPSGTEPVLRVYAEGRSPQMVKALLGYGEQVAASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N311</accession>
    <name>E8N311_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561502.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31350"/>
    <dbReference type="EnsemblBacteria" id="BAJ65161">
        <property type="protein sequence ID" value="BAJ65161"/>
        <property type="gene ID" value="ANT_31350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31350"/>
    <dbReference type="HOGENOM" id="CLU_265450_0_0_0"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1254" mass="138326" checksum="0B237A59A7EA0FC5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N312</accession>
    <name>E8N312_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_31360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561503.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31360"/>
    <dbReference type="EnsemblBacteria" id="BAJ65162">
        <property type="protein sequence ID" value="BAJ65162"/>
        <property type="gene ID" value="ANT_31360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31360"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792457_0_0_0"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="144" mass="16088" checksum="5342F1F40562C4E5" modified="2011-04-05" version="1">MQWQQWSPDGEEIAFTYNAGDGQGTSIYLIRPDGSGLRKLASRAAEPVWSPDGSQIYFFSNLTGQVEIWRIRRDGSGLQQVSSLYPQVNVDHSLRISPDGAQLAFYGVGPEVAEYGTEIYVLNVDGSNLRSITLSRGQEEWLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N325</accession>
    <name>E8N325_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561516.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65175">
        <property type="protein sequence ID" value="BAJ65175"/>
        <property type="gene ID" value="ANT_31490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31490"/>
    <dbReference type="HOGENOM" id="CLU_573241_0_0_0"/>
    <dbReference type="OrthoDB" id="2224529at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.290.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036698">
        <property type="entry name" value="TM1070-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225437" evidence="1">
        <location>
            <begin position="27"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="476" mass="49953" checksum="878344359F676E5D" modified="2011-04-05" version="1">MLKKSLVSLLSAVLILTLVLVTSASAAATTKSLSTNFTLVNLGSSSADVVVDYVKPDGTPWTGSSYTTANIPADGGQWIVRQYFDTLTPGQGSVVISATQPLGALVQLINRSGVPTSGAYKGFTAGTAKAYVPLVARQGTSATGTANSQIMIQNIGSAAIDVQVALTQVGDTTPDYTKTITGIAPKATYTYDISDETNLPTNWYGSAEVSVTTAGGQVAVVSNLFFGADSLMTFSGFPQESVDSVWFVPLLYSRLTNSLNTSLAIQNLDTTDIAVGDLVLNCTKDPAYTGPNTLTLSNATVIPVKGSYTFNTLVDTTNFPTNWQGSCKVSVTSGKKVVALVMYRWVSTKDQAAYEAIPGSSTGTTAYVPLVAKRLSNGFATTITIQNLSTNPATVTLTYTPSGGGTPIVRTGITIPAESSIVRNFRLSATELPEITDGWQGSLKIVSDQPVHAYIANTYITPPNGDQFMAYTALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N339</accession>
    <name>E8N339_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31650"/>
    <dbReference type="EnsemblBacteria" id="BAJ65189">
        <property type="protein sequence ID" value="BAJ65189"/>
        <property type="gene ID" value="ANT_31650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31650"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_1_0"/>
    <dbReference type="OMA" id="DALIMWT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="183" mass="21110" checksum="D61DBDBE6AB1B6FC" modified="2011-04-05" version="1">MTPAEIRIRPMQVEDIPEVHALDVLSFRLPWSERSYRFEVTENTASSPWVAEALFPDGSRRIVGMMVNWIILDEVHIATIAVHPDFRRMGIACRLLMEGLQEGYRRGARMAFLEVRRSNTAAQRLYESFGFRVEGVRPKYYQDNQEDALLMSLKPLDEEVLRRMADRAEPNPSGGERCNPIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B8</accession>
    <name>E8N3B8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_08980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559324.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08980"/>
    <dbReference type="EnsemblBacteria" id="BAJ62932">
        <property type="protein sequence ID" value="BAJ62932"/>
        <property type="gene ID" value="ANT_08980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08980"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="OMA" id="WPAVQHN"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="294" mass="33051" checksum="9C668657653B5CFB" modified="2011-04-05" version="1">MNRSFNRTAYLYLFPALVIYGIFVLYPILQTAYYSLTDWNGLSSPQFLGLQNYLNLFQDSVFLNALFNNLAFIFFYSILAIVLGLFFAVLLTNAPLRGMAFYRAGLFFPQVMASVVIGMVWRWIYHPQYGALNQFLRSVGLGAWARPWLGDFDWALTAVGIVGTWAQYGFCMVLFLAGIQNISTALYDAARIDGAGLFQQFWYITLPGLRNQLLVALISTLIAAIRIFDLVFVTTRGGPGNATLVAGMYLYRNAFVINRVGYAAAIAVLLTVLILVISYFILRLQRAQDEESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F3</accession>
    <name>E8N3F3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09330"/>
    <dbReference type="EnsemblBacteria" id="BAJ62967">
        <property type="protein sequence ID" value="BAJ62967"/>
        <property type="gene ID" value="ANT_09330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09330"/>
    <dbReference type="HOGENOM" id="CLU_2663056_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="75" mass="9309" checksum="B04769C73BEDC151" modified="2011-04-05" version="1">MEFSRVYSEQEKPEKECGAMMRRIFWRVSRPRWGRAGSRFWLRRIREGGWLFFSFLFAGLALVVFLLYVFNWFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G4</accession>
    <name>E8N3G4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase U32 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559369.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09440"/>
    <dbReference type="EnsemblBacteria" id="BAJ62978">
        <property type="protein sequence ID" value="BAJ62978"/>
        <property type="gene ID" value="ANT_09440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09440"/>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011540_5_0_0"/>
    <dbReference type="OMA" id="MKDNNQS"/>
    <dbReference type="OrthoDB" id="1264653at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020988">
        <property type="entry name" value="Pept_U32_collagenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12392">
        <property type="entry name" value="DUF3656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3656" evidence="1">
        <location>
            <begin position="383"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="628" mass="71011" checksum="C3746E656A7EADA8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W1</accession>
    <name>E8N3W1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63125">
        <property type="protein sequence ID" value="BAJ63125"/>
        <property type="gene ID" value="ANT_10910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10910"/>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_779979_0_0_0"/>
    <dbReference type="OrthoDB" id="988224at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="355" mass="38452" checksum="36564BAAF844532B" modified="2011-04-05" version="1">MRSPVNFLGFPVGLLRTWPGVLMLAWVGIWLSGCLSATPTLAPGPIPTETPTPQPTSTATPVPLGEVENPIVFGYIDAGSVEQPPAADRVIQQIAGQTGLAIRAESFSTYRQLLEAMEKTDVHLAWMPPLTYLYASQRGIAEVGLLSNHFGVYRYGVQFLVNASSGFQLYFDPLSGQNSADAATALRQFEGKRPCYVEPTSAAGYLVPAGLLARNGIRTAEPVFTQTHSGIVRTLYVQGVCDFGATFAISGDPRTSSAVLQDLPDALERIPVVWRSDPLIPNLALVYAAGMSEEMQQTLEQALIDLVKSDEGRSNLSLFADYEIEDLRVVDDSLYDPLRETLAALGVRYAELIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Z2</accession>
    <name>E8N3Z2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_11220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559545.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11220"/>
    <dbReference type="EnsemblBacteria" id="BAJ63156">
        <property type="protein sequence ID" value="BAJ63156"/>
        <property type="gene ID" value="ANT_11220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11220"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2434453_0_0_0"/>
    <dbReference type="OrthoDB" id="1718602at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="90" mass="10106" checksum="3506AB6C27C64D77" modified="2011-04-05" version="1">MCGRFTLFLDAETLQEVFGVSEIPADYTPRYNIAPSQPVGVITNLHPQRMEWMRWGLIPSWAKDPAIGERMINARAETLTDKPCSVAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N412</accession>
    <name>E8N412_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosidase</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_11420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559564.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11420"/>
    <dbReference type="EnsemblBacteria" id="BAJ63176">
        <property type="protein sequence ID" value="BAJ63176"/>
        <property type="gene ID" value="ANT_11420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11420"/>
    <dbReference type="eggNOG" id="COG3940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_4_2_0"/>
    <dbReference type="OMA" id="YCFYSGG"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="36096" checksum="2D9B3871DD1F7518" modified="2011-04-05" version="1">MESTYQNPLSITHIGDPFVLKAPDGKYYCYATSAPDGFKAWCSIDLVHWESLGYVYSLTEKSWGERDFWAPEVIYYQGKYIMHYTARWKENHSLRLGVAISEKPEGPFIDVFSHPMFDFGYATIDGHVFIDDDKRAYLYYSKDCSENIVDGRHESHLYVVELESNLLSIRGEPVKIAQPEQEWELRSGNEWRWNEGPFMIKRNGKYYLMYSANFYASRDYAIGYAIANHPLGPFQKAAHNPILYSTSPEISGPGHNSVISSPDGKELFIVYHIHTNPDCPSDDRQICIDRLLFQDDDTLHVLGPTNTPQPLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N450</accession>
    <name>E8N450_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_11800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11800"/>
    <dbReference type="EnsemblBacteria" id="BAJ63214">
        <property type="protein sequence ID" value="BAJ63214"/>
        <property type="gene ID" value="ANT_11800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11800"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304346_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="538"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="575"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="976" mass="108023" checksum="0793E2994715ED5F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N470</accession>
    <name>E8N470_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative M24B family peptidase</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_12000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559622.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63234">
        <property type="protein sequence ID" value="BAJ63234"/>
        <property type="gene ID" value="ANT_12000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12000"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_3_0"/>
    <dbReference type="OMA" id="PWEQNEA"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="162"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="412" mass="45824" checksum="8FD14D3F53FEB8C7" modified="2011-04-05" version="1">MKSDLHRLMAENELDAIWVIGPAAHNPPMVYLTGGGHITQADLILKRGEKGVLFHGPMERDEAARTGLITRSYSSYPFAEFLKEANQDRFRASVLRLKRMLEDLGLTRGRVMLFGQYDAGVAFALFDALQKELPELSILGDVENKVLQQAMLTKDREEVERIRRVGQKTVEVIDLTADYLRSQRLKGDVLVDAQGEPITVGRVKRLINLWLAERDLENPEGTIFAIGRDAGVPHSSGKAEDVLRAGQTIVFDIFPCETGGGYFFDMTRTWCLGYAPGAVEKLYEQVLTVFHAVSSEVRVHGHFRDLQRRTCELFEGMGHPTVLTQPQTEVGYVHSLGHGVGLNIHEKPVSGLMASPEDDVLLPGSVVTIEPGLYYPDQNMGVRLENTVYLAPDGKIETLADYPLDLVLKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B2</accession>
    <name>E8N4B2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine biosynthesis protein LysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559664.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12420"/>
    <dbReference type="EnsemblBacteria" id="BAJ63276">
        <property type="protein sequence ID" value="BAJ63276"/>
        <property type="gene ID" value="ANT_12420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12420"/>
    <dbReference type="eggNOG" id="ENOG5033BTG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195720_0_0_0"/>
    <dbReference type="OMA" id="HQIVECP"/>
    <dbReference type="OrthoDB" id="2076643at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd13946">
        <property type="entry name" value="LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="PTHR40393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01206">
        <property type="entry name" value="lysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="55" mass="5998" checksum="8631BBBDB3E52BA8" modified="2011-04-05" version="1">MTTAYCPECDAPISLEDVMVGEILVCPDCGVDLEVLSIDPPQVELAPMEEEDWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B6</accession>
    <name>E8N4B6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_12460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559668.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63280">
        <property type="protein sequence ID" value="BAJ63280"/>
        <property type="gene ID" value="ANT_12460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12460"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059523_1_2_0"/>
    <dbReference type="OMA" id="YQHNHSE"/>
    <dbReference type="OrthoDB" id="1194699at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="250" mass="28816" checksum="007FCBE6729C8FE0" modified="2011-04-05" version="1">MSPIPVGVQLYSVREDCARDLPGTLKSIAQMGYEGVEFAGFYGHSARQLRQWLEENGLKCCGAHIPLSDLSEETFQQTVEFHLELGNPYLVVPWLPEEFRSSRAAWLKTAEYFSQLSERLEPHGLRLGYHNHDFEFDWMDGEVQFDIFFSATNPKVFMQLDTGNAMHGNADPLEYLQRYSDRAVTIHLKEYSSKNPLALPGEGEVPWQDVFAMCECCDVTEWYIVEQEQYAVPPLETIARCREFLRKMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C4</accession>
    <name>E8N4C4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bidirectional hydrogenase Y subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hoxY</name>
        <name evidence="3" type="ordered locus">ANT_12540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559676.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12540"/>
    <dbReference type="EnsemblBacteria" id="BAJ63288">
        <property type="protein sequence ID" value="BAJ63288"/>
        <property type="gene ID" value="ANT_12540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12540"/>
    <dbReference type="eggNOG" id="COG1941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093095_0_0_0"/>
    <dbReference type="OMA" id="CNAENVH"/>
    <dbReference type="OrthoDB" id="1280734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="14"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="177" mass="19715" checksum="271103D571B9965C" modified="2011-04-05" version="1">MEKLKLATIWLDGCSGCHMSFLDIDERLLALSDRVELVFSPLVDTKDFPEDVDITLVEGALGTEEDLQKIRKIRERTKLLVAFGDCAVTANIPSMRNPFGREEVLKSLYVESDALNPQIPVQSLPELLPHALPLHHYVHVDVFLPGCPPAADTIYQVLSELIEGRIPDVNPLTRFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E4</accession>
    <name>E8N4E4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_12740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559696.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63308">
        <property type="protein sequence ID" value="BAJ63308"/>
        <property type="gene ID" value="ANT_12740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12740"/>
    <dbReference type="eggNOG" id="COG2270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017518_3_0_0"/>
    <dbReference type="OMA" id="WAFYDWA"/>
    <dbReference type="OrthoDB" id="1249292at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="435" mass="47810" checksum="2B9960A9268A94C4" modified="2011-04-05" version="1">MDEKQHKRAIRAWTMYDWANSAFATTIMAAVLPVYYASVAAANLPGNLATVYWAYTTSISLLIAAILSPILGAVADFSGAKKRFLTIFMLLGVTATALLYFVRTGDWLMASIFFILGDLGFAGSLVFYDSLLPHVAGPDEIDQVSSRGYAIGYLGGGLLLAINLAMIMLAPQELTGLMTRLSFLSVALWWFVFSIPLLKWVSEPPRRIMPGESGRNPIAVSFKRLGHTFREITRYRDLFIFLVAFWFYNDGIGTIIKMATIYGAEIGIGQTTLIGTLLMVQFVGIPFAFLFGWLAKKIGTKKSIYLSLLVYTGIAIAGYFMQKEWHFWALGFAVATVQGGSQALSRSLFGRMVPKSKSAEFFGFFSVSEKFAGIAGPLIFGLVSQFMGNSRLGIISLILFFIIGASLLTFVNEKEGIRVAEKEEKELIEAAVSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G0</accession>
    <name>E8N4G0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_12900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559712.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63324">
        <property type="protein sequence ID" value="BAJ63324"/>
        <property type="gene ID" value="ANT_12900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12900"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_0"/>
    <dbReference type="OMA" id="MEFTGAR"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228173" evidence="3">
        <location>
            <begin position="23"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="27"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="376" mass="39849" checksum="E2322E2D171D44C2" modified="2011-04-05" version="1">MKTRIAVFVLLVVALLVTACQAGGGGTIKVAVLAPMSGQVSTFGISTNNGVQLAVEEWNAKGGINGKKIETVVADSQCSADPAVNAANKVIQEDKVKFIIGEVCSSASIPVSEIAEANQVIQISPTSTNPQVTLNKDGSTKKYVFRACFIDPFQGTVMAKFALDKGYKTAFIMFDQGNDYVRGLAEYFEKAFTEAGGQVVGKESYTKTDTDFSAILTKVAESKAEVLFLPDYYPIVNLVGAQAKEKGVTAVMMGGDGWDSADLDLKAADGGFFSNHYSPEDPRPIVQSWVANYQKKYNAVPDALATLGYDAANLLFAAIEKAGTDDTTKVAEALASLQYEAVSGKITFDAQHNPVKNAVVLSVKDGKVSFSASVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4H5</accession>
    <name>E8N4H5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_13050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63339">
        <property type="protein sequence ID" value="BAJ63339"/>
        <property type="gene ID" value="ANT_13050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13050"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2748939_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="70" mass="7638" checksum="5D3613A3A7862B91" modified="2011-04-05" version="1">MEKPTITIRLRDQKYTIQGASTVREALEILQIPPELFLVVRNGELLDGETPLNDGDFLQLVGAISGGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I6</accession>
    <name>E8N4I6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative arsenical pump membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_13180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559737.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63350">
        <property type="protein sequence ID" value="BAJ63350"/>
        <property type="gene ID" value="ANT_13180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13180"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_3_0_0"/>
    <dbReference type="OMA" id="SWGYYFK"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="29"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="408" mass="44070" checksum="30A00EF6FD3FFDA1" modified="2011-04-05" version="1">MNFWINLVIVLVTYVGIALGKWPRLSVNRTTLTVIGVGLLLAFGQIPFEKLRDYLDIDTLILLFSMMVVNAHLQLAGFFRVAAHLLFRLTRGPKVFLAVEILLAGVLSALFLNDTICLMLTPLVLSLLLSLGRNPIPYLIALATAANIGSTATLTGNPQNMIIGVSSGIPYAQFAGALTPVALLGLGVVWVVLVLFYPQEFRDKRFPDMQSSQLNILRPQLTKTLLVILAMLVGFLAGVPVALAAFLAACVLFFTRRVDPDKVLAEIDWSLLVFFAALFILTGALEANGITQRLFEALNFQGNLNVLGLTSVSVVLSNLVSNVPAVMLLRPVVAGSAQPVAGWLTLAASSTLAGNLTLLGSVANLIVAEIASRRQVNLSFGEYTRSGVVITFLTLIISVLWLQAMVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4I8</accession>
    <name>E8N4I8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">obg</name>
        <name evidence="11" type="ordered locus">ANT_13200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559739.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13200"/>
    <dbReference type="EnsemblBacteria" id="BAJ63352">
        <property type="protein sequence ID" value="BAJ63352"/>
        <property type="gene ID" value="ANT_13200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13200"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_1_0"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="159"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="342"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="308"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="419" mass="45789" checksum="8C505285217D7E81" modified="2011-04-05" version="1">MFVDEAIIKVRGGRGGDGMVHFHREKYVPHGGPDGGDGGRGGNVVLEVKPTLNTLVAFRYKDRYHAQDGARGGPNNMSGKSAPDLIIPVPPGTVVMDAETGELLGDLTQPGQRLIVAHGGRGGRGNQHFATPSNQVPKMAEKGEPGEERILRLELKLIADVGIVGVPNAGKSSLLAAVTNARPKIADYPFTTLEPNLGVAELDINTTLVLADIPGLIEGAHQGVGLGDAFLRHIQRTRVLIHLLDGLSEDPLADYSQINTELALFDEKLAEKPQLVALNKIDLPEVQERWPEIQKQLRNHGVEPYAISALARTGVKELLWKAAEMLQKAPKVEEIPALPVYRPGEDPRAFTIERVPGGWRVHSKALERAASMTYWEYEAPVRRFQKLIETLGVEEALRKAGIQEGESVFIGDYELEWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L8</accession>
    <name>E8N4L8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63382">
        <property type="protein sequence ID" value="BAJ63382"/>
        <property type="gene ID" value="ANT_13500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13500"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045945_3_0_0"/>
    <dbReference type="OMA" id="IWEKRYN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="198"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="37472" checksum="2F220D678A29491B" modified="2011-04-05" version="1">MNNENHHAHNRNDLPVYNIKAISQLVGLLPVTIRAWERRYGLPTPRRGQQGYRLYSEYDLKTLRWLKAQIDAGMNISRAVEYLNELRKNGQDPAISPSPATFSIPSLITTPEVSNLRLEFLDKLLAFNELQATEVLRRAFSLYSVDQVLTEIITPVLVEIGERWHRGELSIPVEHFATQFVMQHLMSMMTVTSQPTRPKKIFAACAPGEMHQIGILMLVVMLRWRGWEVIYFGADLKLDRLEETLNSIQPELIMFTANNLQNALHLTELPSILHKVKGKKPLVVLGGQAFQSNRLPENVAAIYLTGMRPSEIVSRIEALLLSDEKIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R5</accession>
    <name>E8N4R5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">radC</name>
        <name evidence="8" type="ordered locus">ANT_14010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559811.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63429">
        <property type="protein sequence ID" value="BAJ63429"/>
        <property type="gene ID" value="ANT_14010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14010"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073529_0_2_0"/>
    <dbReference type="OMA" id="AMPDYEL"/>
    <dbReference type="OrthoDB" id="1833204at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="111"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="235" mass="25759" checksum="3EDBB072697CB860" modified="2011-04-05" version="1">MAVKENLQTYRIRDIQETDRPRERLAELGAQSLSNAELLAILLRVGLQGENAVQLGQRILVTLGGLHGLHRASFAELSAIKGVGMAKAAQLKAAIELGRRLTMVEPQERASITCPADAAELVRYEMSALLQEHLRVILLDTRNRVLKIENLYIGSLNASTVRVAEIFRPAIQASAASLILVHNHPSGDPSPSPEDITLTRTVIQAGKMLDIGVLDHLIIGQNRWVSLKERGLDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4U3</accession>
    <name>E8N4U3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_14290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63457">
        <property type="protein sequence ID" value="BAJ63457"/>
        <property type="gene ID" value="ANT_14290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14290"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013746_1_0_0"/>
    <dbReference type="OMA" id="RKERQHT"/>
    <dbReference type="OrthoDB" id="859969at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018704">
        <property type="entry name" value="TPR_21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09976">
        <property type="entry name" value="TPR_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="TPR_21" evidence="7">
        <location>
            <begin position="107"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="6">
        <location>
            <begin position="691"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="839" mass="95437" checksum="041BC661ED579901" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X8</accession>
    <name>E8N4X8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559874.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14640"/>
    <dbReference type="EnsemblBacteria" id="BAJ63492">
        <property type="protein sequence ID" value="BAJ63492"/>
        <property type="gene ID" value="ANT_14640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14640"/>
    <dbReference type="eggNOG" id="COG2802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048359_1_1_0"/>
    <dbReference type="OMA" id="WPDEPGA"/>
    <dbReference type="OrthoDB" id="1474822at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="226" mass="26597" checksum="835DC046E776A8C6" modified="2011-04-05" version="1">MYTLPVFPLQTVLFPKTPIHLHIFEERYKKMMRQVLETDLLFGVCLIHQGVEAYGPMPVPYPVGCSARIIDVQPLSEGRMNLTAIGEERFRIRSLVQHSPYLVAEVEAHPFRQIRTLETLRMKNALLEYLSEYVQLLDTYKAAGVELQTLNLFLEELKNYEDPTNIIFLTASLLQIPLIEKQHLLERETVPEILERLILTLRREILLHKRIFWHPEKIVNRIFRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y4</accession>
    <name>E8N4Y4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63498">
        <property type="protein sequence ID" value="BAJ63498"/>
        <property type="gene ID" value="ANT_14700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14700"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_3_0"/>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="36100" checksum="5A59C93278AA29DF" modified="2011-04-05" version="1">MGELNLTSAVSFMVSIQDDLRAVETLMRSQADERYPDLQSALDLLLSAGGKRIRPTLTLLAGKMLRAKGEPLLHLAAAIEMLHTATLVHDDLIDGSLLRRGMPTLNSRWSPGATVLTGDYLFARAANLAAQTDSIPVMKLFSETLSIIVGGELTQMFSTRCKADRTNYYQRIYAKTASLFETSAKSAALLCLTSELHTEALRAYGYSVGMAFQIIDDILDYTGEQATLGKPIGSDLRQGLVTLPAIYFAEMHPEHPLTINLIEGNCIQDQDVLDELIGAIRSSKAIQQSHQEAIQFVETALNHLSIFDPCPERLALEELAHHVVDRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N506</accession>
    <name>E8N506_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_14920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559902.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14920"/>
    <dbReference type="EnsemblBacteria" id="BAJ63520">
        <property type="protein sequence ID" value="BAJ63520"/>
        <property type="gene ID" value="ANT_14920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14920"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034756_1_1_0"/>
    <dbReference type="OMA" id="GVHHDYP"/>
    <dbReference type="OrthoDB" id="2048011at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid alpha-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="PTHR12863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="10">
        <location>
            <begin position="65"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="213" mass="24720" checksum="25000C02F95D78A0" modified="2011-04-05" version="1">MAHYPIDHSDVPIRLFKSGFLEFFTHISPVVVVIIWLPVAVAFMALEVLSGGYAARGVGYLVGGFFVGVFLWTFAEYTLHRFLFHYQPKDPKWERIFFLFHGVHHAQPQCKTRLVMPPVVSIPMAFIMYGIISLIFSILLGLPHWVFPVMSGFIVGYLFYDLTHYATHHFPMRRGIWKYLKRYHMQHHYKTPNARFGVSSPLWDVVFGTKPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N550</accession>
    <name>E8N550_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_15360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559946.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15360"/>
    <dbReference type="EnsemblBacteria" id="BAJ63564">
        <property type="protein sequence ID" value="BAJ63564"/>
        <property type="gene ID" value="ANT_15360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15360"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="AWISESI"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="251"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="474" mass="53471" checksum="84CDCBE30E9060AA" modified="2011-04-05" version="1">MRSISFRTLLTGLLFVGFIPLLLLIGLIVYGFQRTYLMEQAKSQLSSFIRVEIENLDPNSNLSLLAVQTGERIRPLGADLFIKDKDGNPVPPALGTGPWLEDEIHKNALIHQKAQFLTIHTDSGDRLVFLSPILSSEGMALGTLESSISLSGIQTQLLVLQRWLILLIGFSIFLVGIISQGISTFSLRPIQNLVKTAEKVREGDLHTRASTTSIIEINELAFTLNQMLTRLEEDIDAQRKLNQTMRQFAADASHELRSPLMVFNNSVDLLRKFVEEKNFLQMIEILNVLEREVQTMSRLVDNLLLLARLDQAQEDPTKILRVEEIEPLPLIEEIYERAKLLSQGQRIVMRLPSKNLKSLTADRSMLTHALNNLIENAIQHTPPEKGIFITAESEERYCIFVIQDEGTGIPKNQIPFIFDRFYRVDTSRSQRKSGAGLGLAIVQSIVHLHQGKIEVFSDEGKGTTFKVFIPYGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A9</accession>
    <name>E8N5A9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ordered locus">ANT_15970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560003.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63623">
        <property type="protein sequence ID" value="BAJ63623"/>
        <property type="gene ID" value="ANT_15970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15970"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_1_0"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="155" mass="17432" checksum="BDE8E9F168F8345E" modified="2011-04-05" version="1">MAEIHYLTADGLRRLQEELEYLKGPAREELSKRLRFAIQQGDLSENADYIQAKEEQGFLEGRILELTQILNNYVLIEENNNHKDVVNLGAKVTIQEEGFEPETYQVVGPKEADPKKNRISHESPIGKALIGRGVGEVVTAETPTGKITFKILSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B8</accession>
    <name>E8N5B8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560012.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63632">
        <property type="protein sequence ID" value="BAJ63632"/>
        <property type="gene ID" value="ANT_16060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16060"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_1_1_0"/>
    <dbReference type="OMA" id="KNTIYFY"/>
    <dbReference type="OrthoDB" id="1728504at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="194" mass="22202" checksum="25B5717CE7DE43FD" modified="2011-04-05" version="1">MNAEIQNPSSSTVNELLAFFKALSDANRLRILGVLANQSMSVEQISTSLNLSPSTVSHHLAKLSEAGLVTAKPESYYNIYSLNSATLEEMSQRLLRKENLVQLAEEIDLESFDRKVIRDYMTPTGKLKTIPAQEKKLLAILRYLAQSFETGKSYSEREVNEILKKFHDDFASLRRYLIDYGFMQRENGVYQRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5C3</accession>
    <name>E8N5C3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">recX</name>
        <name evidence="6" type="ordered locus">ANT_16110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560017.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16110"/>
    <dbReference type="EnsemblBacteria" id="BAJ63637">
        <property type="protein sequence ID" value="BAJ63637"/>
        <property type="gene ID" value="ANT_16110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16110"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066607_4_1_0"/>
    <dbReference type="OMA" id="MNYLSYQ"/>
    <dbReference type="OrthoDB" id="2025178at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="227" mass="25869" checksum="C5BD8D0E8A6BD516" modified="2011-04-05" version="1">MAGVITALESQKRNSQRINVFIDQRFAFSLSRIVAAWLTVGQFLSDEKIEQLKQEDAIEVAMQSGLQLLSVRPRSEAELRGRLQTKGFSETVIESVITRLKQGGLVGDAEFARMWSEQRQALRQKSRKVIALELRQKGVTDEIVQEVLAESLPDDKVAYLAGKKYLRRIIHLEKSQFLQKMIGYLARRGFSYEVSRETAYRLWQEVSGGSSKSNGREELELWDSLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G3</accession>
    <name>E8N5G3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="7">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_16510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560056.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63677">
        <property type="protein sequence ID" value="BAJ63677"/>
        <property type="gene ID" value="ANT_16510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16510"/>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089926_1_0_0"/>
    <dbReference type="OMA" id="CFQPETW"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="190" mass="21116" checksum="FBC66F883CC7BBCE" modified="2011-04-05" version="1">MNTYKVPELRIHAILPESVANGPGKRTVIWVQGCSLGCAGCFNPQTHSFHQGTRVNPLELAQEILSQQTSIEGITLTGGEPLFQIEALESLLSTLRANSSLSVILLTGFEWDEIFRLQGDRLFPYVDVIISGRFIKEKRLAQSFIGSANKEFHFLTTRYSLSDFQDVPVCEITISPEGNTFITGIDPLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G7</accession>
    <name>E8N5G7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative L-threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560060.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16550"/>
    <dbReference type="EnsemblBacteria" id="BAJ63681">
        <property type="protein sequence ID" value="BAJ63681"/>
        <property type="gene ID" value="ANT_16550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16550"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_19_1_0"/>
    <dbReference type="OMA" id="HWHASPR"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="339" mass="38728" checksum="277BEC81380E7BE2" modified="2011-04-05" version="1">MRKEVVLITGANGEIGHGLITYLGQQGNVNIIALDVQPLDEELKPYCMRTIQGDILDQMLLGRMVVEFEIRSIFHLASILSTKAEYNPETAHRINVEGTLNLLRLAVEQSQWQGQPVKFIYPSSIAAYGIPSLEVKNSLGKVKENEWGNPITMYGCNKLYCEHLGRYYAYHYRQLAAEPEKSSIDFRCLRFPGLISAMTVPTGGTSDYGPEMLHHAAQNLPYKCFVRPDTRLPFMAMPDAVKALLMLHEAPREKLTQTVYNVTSFSPSAEEIYHMVLKYFPQAQVEFSPHLSRQRIVDSWPADIDDSVARQDWGWKPDYDFERAFEEYLIPAIRQRYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J5</accession>
    <name>E8N5J5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pepA</name>
        <name evidence="10" type="ordered locus">ANT_16830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560088.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16830"/>
    <dbReference type="EnsemblBacteria" id="BAJ63709">
        <property type="protein sequence ID" value="BAJ63709"/>
        <property type="gene ID" value="ANT_16830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16830"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_0"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="476" mass="51596" checksum="FC296D8C982CF33D" modified="2011-04-05" version="1">MKSPTHPNIPFQITIAPDKTLAELEVSLIFAPDSPKLGEPATAGESLFLQDHGKSRLVVSLGKQEKINQETYRKVGGSIGKWLINHPVQSVELSVSWLYEENNLDSLYALLEGILLGGYQFQRYKQNNEPEKVISVFLRTDSMSVKDLVERLNIVTRAVYLARDWAHEPANVINPVTLAEWTETLAEENGLTCTILDDQTLSKIGAEGILSVGKGSHTPPRMIILEYRGGLSDTSPLILIGKAITFDTGGYSLKDTTNIQGMKYDKCGGIAVIATILATALLKLPINVVGIVGAAENMISSTAYRPDDILKTLSGKTVEIISTDAEGRLVLADALTYAQTHYTPRAIIDLATLTGGVIVALGRVFGGVMGNNPSLIQNLIESGEASGERLWQLPLDEEYLQALKGDDADLKNSGGREGHAILGGMFLKQFVDDSIPWAHLDIAGVANTPKDLPYSPKGPTGFGVRLLIEFLKKFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K1</accession>
    <name>E8N5K1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_16890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560094.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63715">
        <property type="protein sequence ID" value="BAJ63715"/>
        <property type="gene ID" value="ANT_16890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16890"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_0"/>
    <dbReference type="OMA" id="YRAVVMS"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="140"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="389" mass="43823" checksum="C7A1C2BF59135F56" modified="2011-04-05" version="1">MSLTILVVDDEENFRVNTERYLATRGYEVIGASTLQEAREILIKGIADIVLLDVQLPDGYGPNLLYETTQMVFRPPIILITAYGDIDMAVDAMRNGAHDFLTKPIQYNQLEKSIERASEIVTMRRELLHLRQAQKNQNFVAGKNPKMQSVLAMAKRAAEMSVSVLITGETGTGKEVLAKFIHSSGPRANKPFVPINCAAIPNTMLEAELFGYEPGAFTGAEKRKHGLMEVADGGVLFLDEISSMPLDIQAKMLRALEERAFRRVGGLNQVKVDVQIVAASNRDLAQMIKDGNFREDLYYRLKVVDLHLLPLRERKEDIPELVVFFIRQNNMRLGMNVRDVTPRAMEVLMRYHWPGNIRELSNSIERAMLFCNGEVIDLPDLPDLSIHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N0</accession>
    <name>E8N5N0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NarL family two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_17180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560122.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63744">
        <property type="protein sequence ID" value="BAJ63744"/>
        <property type="gene ID" value="ANT_17180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17180"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808392_0_0_0"/>
    <dbReference type="OMA" id="EDCHEAT"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="230"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="355" mass="39717" checksum="CC662A2AF28DBD63" modified="2011-04-05" version="1">MKPFRVLLADDHEVVRAGIRRVLEEIENIQVVAEVGDGKTLQQEIARQLPDLILIDVTMPDFDPISAIHSIRLNYPTLKILVVSAYDDNVYVQGLLSAGVHGYHLKDQPLNDLKLAVQRVLSGDHWISSPLIGKLVHALSNSSIPGLTPRQQEILLYLWEGKDNQQIARLTGLSVKTIENHLTRLYRLLNVQSRLEAVNYLNQHPELLGQHNPTSHNSPEHSSKSDFPVAVLIVDDNPRFRQQLAHVMGKINNHLSVYESGDITSAVLISQKIKPLVAFIDVVLRGDENGIQCTRRIRAVSPQTRVVLISAYPDREFHRLGMEAGAVAFIDKKDLDVKTLRTILEDCISTTTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P3</accession>
    <name>E8N5P3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560135.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17310"/>
    <dbReference type="EnsemblBacteria" id="BAJ63757">
        <property type="protein sequence ID" value="BAJ63757"/>
        <property type="gene ID" value="ANT_17310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17310"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_0"/>
    <dbReference type="OMA" id="FQKYGDQ"/>
    <dbReference type="OrthoDB" id="311458at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="261"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="385" mass="40993" checksum="302DCA9FD9643E59" modified="2011-04-05" version="1">MREVAVLGIGQTKIDEHWDKSLRELAGEAILAAMLDAGITRADALYIGNMMSGSANHQQHLGTYMADWVGIKGAEALHVEDACSSGAAAFRSAVMAVASGAVDVAIAAGVEKMTDSPGNEITAELATAADQDWEASQGLSFVALNALIMRRYMYEYKWERDHFAGFSINAHANGVHNPFARFQEAISEAQYRKAPMIAEPINLLDASPMGDGAAAAVLVPAEMLRRGNGRKIIRVVGSGAATDTIAIHHRRDPLWLSAAEKSVKQAYSQAKIGPEDIDLFEAHDAFTIMAALSLEACGFAERGQGPRLAMEGEIRPNGKIPIATRGGLKARGHPVGATGMYQIVEVVQQLRGEAGATQVDGARYGMAQNIGGSGSNIITHILMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N607</accession>
    <name>E8N607_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_18450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560248.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18450"/>
    <dbReference type="EnsemblBacteria" id="BAJ63871">
        <property type="protein sequence ID" value="BAJ63871"/>
        <property type="gene ID" value="ANT_18450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18450"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_3_0"/>
    <dbReference type="OMA" id="IEWHMIG"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="35"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="244" mass="27537" checksum="09D0A20D7BB50671" modified="2011-04-05" version="1">METLVRHIRERYLRVEEQVAQSAFEVGRDPKAIRILVVTKTQPLEVVKASIEAGITLFGENYPEEALPKILALQSQPGIEWHMIGHLQSRKARIVVEHFSVMETIDRVEIAEKLNRFAQGANRVLPAMLELNVSGEESKFGLPAWDDQTFTSMLGAIEKVVSLPNLSIKGLMTMPPLFEKMEESRPYFVKLRKIQDSLRKIFPQVCWDELSMGTSADFPVAVQEGATIIRIGTAILGPRRQKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF2</accession>
    <name>E8MXF2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20070"/>
    <dbReference type="EnsemblBacteria" id="BAJ64033">
        <property type="protein sequence ID" value="BAJ64033"/>
        <property type="gene ID" value="ANT_20070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20070"/>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603627_0_0_0"/>
    <dbReference type="OMA" id="VENYLHE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="2">
        <location>
            <begin position="176"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="453" mass="49643" checksum="2ACC902557CCA152" modified="2011-04-05" version="1">MQFILEIIGQHSCSYGADSMNRRHFLKKLSALSLFPFFKALGVITIGVGSTSCQPKNMEATGENPANNFETPPPAPPEPTHTHSPTPITTIPTATNTLQPTFTPAPPVKAEFGHRVIHVHHAQATRWSAQKRYWEYVDQQVVTQMVEKGITELTGTTTVEDAWRKLLPGYQRGEAIAIKLNFNNTIWESCTGESGQINALPQPVNAVIAGLKSIGVEETDIWLFDGVNRIIPEYFVAGIAFPKVRFFDRCHEPVTYDSQEDSAFVSLHPPEGVQMPTRQKIADVLLQTKYLINMPILKSHSCSSISLGFKNHLGSIDNPGGLHSHIFLVSACGGGFTPQYSPLVDLYLNPNIRDKTILIIGDGLFGAKGSEDAFPTTWSTFGGKVPNSLFFSTDPVAIDSVMADFLRAEPGAGIMKQADEYLLLAEQAGLGKAERGDPWGKGYQEIGYQKIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXH6</accession>
    <name>E8MXH6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-antigen polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560427.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64057">
        <property type="protein sequence ID" value="BAJ64057"/>
        <property type="gene ID" value="ANT_20310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20310"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_561261_0_0_0"/>
    <dbReference type="OMA" id="WEINLRV"/>
    <dbReference type="OrthoDB" id="630858at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="482" mass="53520" checksum="A039DB18004ABEE3" modified="2011-04-05" version="1">MFSRITQKWFKIDLEAIQDWLDEHKNLLIRVIVILGLAGYLFLLPRYAIGKHRIPQMIIFATLGIGGLAVLISQPVLATLLIIPATLLVPFGIGTGTQSNLNAGILMVLACAGLWVLEMIVVHKKISIIRSRPFLPLFLLMVSSVISLGFGQLPWFNMPHASMASQIGGMMMYILAGLTFLVAAHRLSLPSLKWAVVLFLGLGSIYLFLRPLTNRYYSLVYPVVSLFEQGATGSMFWIWILNISVGQLIFNHRMPLLLKIGLGGILLAFFYNSLVLGREWTSGWLPPLLGASAIIFVGFRRTRILIGVFALTAIIATFPSLQSTVMGGNEYSLVTRTEAWEILLKVVQVNPIFGVGPANYYFYTPIFPIRGYYVQFNSHNNYMDLLVQTGIVGLGLFIWFMTEQSILGLRMMTKVPEGFAKGLVYGIFGGTIGTIVAGMFGDWVIPFVYNVGFNGFRASILGWFFMGGLVALEQTFQSQEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXK6</accession>
    <name>E8MXK6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64087">
        <property type="protein sequence ID" value="BAJ64087"/>
        <property type="gene ID" value="ANT_20610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20610"/>
    <dbReference type="HOGENOM" id="CLU_3148849_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="48" mass="5809" checksum="8C47550F89975D84" modified="2011-04-05" version="1">MLPCYRKIAIFFTNSFDVFLTFPDMVFVVFLINNRYNQVWTGKPKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXL0</accession>
    <name>E8MXL0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative type II/IV secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_20650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560461.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64091">
        <property type="protein sequence ID" value="BAJ64091"/>
        <property type="gene ID" value="ANT_20650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20650"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_4_1_0"/>
    <dbReference type="OMA" id="IICVGEM"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="120"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="471" mass="52027" checksum="822A44A3BCBB9ACA" modified="2011-04-05" version="1">MSILKRIQGNNPPQQGGQPPSNGSGINPPTAPNMQATRRIPAPGIPSAQDTYQDLKSRVQTKLLAGLDPTADPSRVPEMRRTIQELFEQILTEENIVLSRPERARMFEQIAAEILGLGPLQSLLDDDTITEIMVNGPKNVYVERGGRIYRAPVTFENNEHVMRIIERIVAPLGRRIDESQPYVDARLMDGSRVNAVIPPISLVGPVLTIRKFARKPITVEQLIQFGSITPEAIEFLKACVVARLNIVVSGGTGSGKTTLLNILSGFIPPDERIITIENAAELQLRQEHVVTLESRPPNIEGKGEITIRQLVINALRMRPDRIIVGECRGDEALDMLQAMNTGHDGSMTTAHSNSPRDTLARLETMTMMAGMELPVRAIREQVSSAIDLIVHQERMRDGSRKVVNITEVSGMEGDVITTTDLFVFEQAGYENGKIIGRLRPTGLRPKFMDKIEAAGIHLPASIFGIGERRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ5</accession>
    <name>E8MXQ5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_21100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560506.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21100"/>
    <dbReference type="EnsemblBacteria" id="BAJ64136">
        <property type="protein sequence ID" value="BAJ64136"/>
        <property type="gene ID" value="ANT_21100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21100"/>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033541_6_0_0"/>
    <dbReference type="OrthoDB" id="1856009at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="38099" checksum="E9F324A06CDBD5F7" modified="2011-04-05" version="1">MEKKQHFLYPVMGLLVTFLLGWVAWRLTRWIYPMTLPFQIPGKALEYPMWAALVGLLGGFFLRKLGKFEEVKSGIRTELFLKVGLILLGAGIDLKIILHAAGGAIIQTLIMITSVFMFSWWITGKFGLDEKLRAVLSSAVSICGVSAAIAAAGSVQAKKEQVTYVATLVILVALPMMVISPLIAQALHLPQAVAGAWFGGNIDTTAAVVGAGTIFGEEAQKIASIVKSTQNTLIGLVAFLLAVYFARKQAGEGTKPSPRLIWDRFPKFVLGFVVASVLYSLGWIDGGKGTAIDALKNWFFTFAFVGMGMDFSLKELNAMGTRPIIAFLIITLFNTLLALGVAWVIFGGWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXR5</accession>
    <name>E8MXR5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-dependent helicase</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560516.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64146">
        <property type="protein sequence ID" value="BAJ64146"/>
        <property type="gene ID" value="ANT_21200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21200"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008466_1_0_0"/>
    <dbReference type="OMA" id="SHNFRNG"/>
    <dbReference type="OrthoDB" id="291634at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="280"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="723"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1141" mass="131975" checksum="2CF89C83215D9A72" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU5</accession>
    <name>E8MXU5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560546.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64176">
        <property type="protein sequence ID" value="BAJ64176"/>
        <property type="gene ID" value="ANT_21500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21500"/>
    <dbReference type="HOGENOM" id="CLU_2230870_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="106" mass="11452" checksum="3B6C6413A5D438DF" modified="2011-04-05" version="1">MNIKPVMIFLLLAGVLLVGLLAVELSGAGRGVDPQVVSLKTQPATATRTPGWWSSVATWTPGPTADPTREVTETVEERSTPTPLLDIPPVRTVEMPTPQPTWTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ0</accession>
    <name>E8MXZ0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560590.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21950"/>
    <dbReference type="EnsemblBacteria" id="BAJ64221">
        <property type="protein sequence ID" value="BAJ64221"/>
        <property type="gene ID" value="ANT_21950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21950"/>
    <dbReference type="eggNOG" id="COG2062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084603_2_2_0"/>
    <dbReference type="OMA" id="DRPLNKR"/>
    <dbReference type="OrthoDB" id="1707924at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="207" mass="23914" checksum="8458FEEB30977A8C" modified="2011-04-05" version="1">MKTLLIMRHGKSSWKDPDLPDRERPLAKRGIKDSRRMGLFIQEKELIPQRILCSSAKRAVQTAQLFCETCGCPDTVEVLDELYMAEAEMYIRALQTLPDELERVMIIGHNPGLEFLLQMLSGELVSLPTTVVAHLTLPVQRWSELNEHTEGTLIEVWKPKELPEEIIEQEKELRKEAKAAEKEVKGKKEKKEKKEEKKGKKKDKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY04</accession>
    <name>E8MY04_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase, chain 4L family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_22090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22090"/>
    <dbReference type="EnsemblBacteria" id="BAJ64235">
        <property type="protein sequence ID" value="BAJ64235"/>
        <property type="gene ID" value="ANT_22090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22090"/>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257866_0_0_0"/>
    <dbReference type="OMA" id="QALIMIM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="103" mass="10952" checksum="7EB9971D97641D55" modified="2011-04-05" version="1">MMFYLPNIVLVVVLALLGIGIYCILISRNLIKVVVGLQIAVKGAFLALVLAGKLASQIDVGQSIALTVIVADTIVAVVALALAVQIRRKFGTLDVHALMSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY16</accession>
    <name>E8MY16_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIRAN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_22210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64247">
        <property type="protein sequence ID" value="BAJ64247"/>
        <property type="gene ID" value="ANT_22210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22210"/>
    <dbReference type="eggNOG" id="ENOG5032SKB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154672_0_1_0"/>
    <dbReference type="OMA" id="ENAIAVH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="HIRAN" evidence="4">
        <location>
            <begin position="40"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="147" mass="16704" checksum="64E8CFEA29B340BF" modified="2011-04-05" version="1">MTRGNLMDSRRDFLKALLGMVAGTIIAPIARKKIPSRQKIVLLETHVAGFQYHEGMRRGVAKTLKSGVPLKLVREPQNLYDENAIAVHTLQGQHLGYIPRSLNEIPARIADQGIPLEAKVVKFHPRNEPWERLLIRVYQVIPEEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY21</accession>
    <name>E8MY21_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_22260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64252">
        <property type="protein sequence ID" value="BAJ64252"/>
        <property type="gene ID" value="ANT_22260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22260"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_8_1_0"/>
    <dbReference type="OMA" id="HPRTYWV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="239" mass="26811" checksum="5C19980BDABE2F3C" modified="2011-04-05" version="1">MRKNAEKQGTYRYILFYKPYGVLTAFTDPEGRPTLKDWIPVPDVYPAGRLDMDSEGLLFLSNDGDLMHRITDPRYQHPKTYLVQVEGVVSGEALAKLRRGVEVKGRQTQRCQVMVIPEPDLPPRAKPVTPHGPTTWLRMVLTEGKKRQVRHMTAAVGHPTLRLVRVAIGPLSLEGLTPGEWRDLTPQELALLKRSLRLTDGRIPAMSAGNARESRYRNAARQSSNRGSRPSGADDPVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY66</accession>
    <name>E8MY66_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_22710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ComB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64297">
        <property type="protein sequence ID" value="BAJ64297"/>
        <property type="gene ID" value="ANT_22710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22710"/>
    <dbReference type="eggNOG" id="COG2045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070028_1_0_0"/>
    <dbReference type="OMA" id="CAQYIAR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37311">
        <property type="entry name" value="PTHR37311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="SSF142823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="230" mass="25554" checksum="0694AB4E81D7B22C" modified="2011-04-05" version="1">MMQFYRVNLNTCAQARGVVVVIDVLRAFTTAGYLFEAGVKEIVLTSTVEEALKLRQQMPGSLLLGEIDGIPIPGFDLGNSPSELSRYDLRGKTVIQRTTAGTQGVIRCLHAENILTAALTNARATATYLERLAPREITFVLTGYFPDEGWGDEDVACADVLEAYLQNRPIDWQEIDQRVRHSRSGKHYDGTREAFPPPDLDMALAVNRFPFAMRVEKKDGLPVLQTVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYA4</accession>
    <name>E8MYA4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558447.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62049">
        <property type="protein sequence ID" value="BAJ62049"/>
        <property type="gene ID" value="ANT_00150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00150"/>
    <dbReference type="HOGENOM" id="CLU_2505542_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="85" mass="9568" checksum="D06D0E74B6C4E4E0" modified="2011-04-05" version="1">MQRTPVARSWVVMMHGGFAALDWGNGLYLDLTRGQFFTATEKDVSHRASDADLDLLVRLGCIEGYDRLNVYLTSLPEPPHETEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYC5</accession>
    <name>E8MYC5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558468.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62070">
        <property type="protein sequence ID" value="BAJ62070"/>
        <property type="gene ID" value="ANT_00360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00360"/>
    <dbReference type="eggNOG" id="ENOG50334A5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1308009_0_0_0"/>
    <dbReference type="OMA" id="FDQPYLD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="210" mass="22346" checksum="2427F5373E929A97" modified="2011-04-05" version="1">MRSPVMTALAIAAGLIVLLGYLIPPEWTSLAYIQAVRAVFIGWAVVLAGIAAWVGVIHLFLTHLRRMSARREADRYSVLVVLAFLATAVAGMILTPADPGFQQAVLAIQVPVEATLLGLLAVTLVFASMRLFQRRKGVMAIVFVVSVVFFLLLGAGLLMPLQQTPLLGGLIGFFERLPIAGGRGILIGIALGSLMTGLRILLGADRPYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD7</accession>
    <name>E8MYD7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein, MgtC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtC</name>
        <name evidence="9" type="ordered locus">ANT_00480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558480.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62082">
        <property type="protein sequence ID" value="BAJ62082"/>
        <property type="gene ID" value="ANT_00480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00480"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_0_0"/>
    <dbReference type="OMA" id="FMLIIMI"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="149"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="222" mass="23641" checksum="F0E3EFB3194F0FD8" modified="2011-04-05" version="1">MIPEGEIFVRVLVAALLGAVIGVEREISNQPAGMRTHIVLVVGAALAMTLSINLSMQFAGLAPGGDPARLAAQVLSGIGFLGAGAILRFGANIKGLTTAASLWTMAVVGLVTGAGYFAVAGGVTALLLVVLTLLNLLENRVINPTVTVEFTVVVEEEPGVIPKIRALLEEHSRALESFRLRHHVRHARFRVDAVVRLNRGKDAETLQQKLSELKGVKIVRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYH8</accession>
    <name>E8MYH8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558521.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00890"/>
    <dbReference type="EnsemblBacteria" id="BAJ62123">
        <property type="protein sequence ID" value="BAJ62123"/>
        <property type="gene ID" value="ANT_00890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00890"/>
    <dbReference type="eggNOG" id="ENOG502Z85H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438493_0_0_0"/>
    <dbReference type="OMA" id="GKSEMCQ"/>
    <dbReference type="OrthoDB" id="236359at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032583">
        <property type="entry name" value="DUF4914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16260">
        <property type="entry name" value="DUF4914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="622" mass="69686" checksum="406A8BE46AE1859E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS1</accession>
    <name>E8MYS1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative DNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_23810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560773.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23810"/>
    <dbReference type="REBASE" id="32154">
        <property type="entry name" value="M.AthUNI1ORF23810P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64407">
        <property type="protein sequence ID" value="BAJ64407"/>
        <property type="gene ID" value="ANT_23810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23810"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013151_0_0_0"/>
    <dbReference type="OMA" id="DFQKKLW"/>
    <dbReference type="OrthoDB" id="161391at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="485"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="997" mass="116410" checksum="C64A747EB8BD788F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX5</accession>
    <name>E8MYX5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">parA</name>
        <name evidence="2" type="ordered locus">ANT_24350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560816.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24350"/>
    <dbReference type="EnsemblBacteria" id="BAJ64461">
        <property type="protein sequence ID" value="BAJ64461"/>
        <property type="gene ID" value="ANT_24350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24350"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_0"/>
    <dbReference type="OMA" id="QGNLSQW"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="258" mass="28413" checksum="F6B639A1BAAD43FE" modified="2011-04-05" version="1">MTKVITIANQKGGAGKTTTVLNLAHGLALRGKEVLILDFDPQGQSASYLGLKQEPGIFFLLMSSIKPLEKNELILLRQQVRSTGRPRLWIIPGSQETAVAQNSLAALDKPVSYIRDAIQVFMRNGLDYIVMDTSPSLGGLQERAIWASDFVIVPVAMEFGSLEGLNKTLSIMRNLKESKGWRGSLGGVLPTFYDDVTRETKKIEEDLKAGLGAMVLPPIHRATVFRESIAEGQTIFEKAPGSRAAQEYERLVDQVLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ00</accession>
    <name>E8MZ00_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpS</name>
        <name evidence="10" type="ordered locus">ANT_01090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558541.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01090"/>
    <dbReference type="EnsemblBacteria" id="BAJ62143">
        <property type="protein sequence ID" value="BAJ62143"/>
        <property type="gene ID" value="ANT_01090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01090"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_0_0"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="13"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="36828" checksum="A63B2CD691AC95CB" modified="2011-04-05" version="1">MSKKGRVFSGARPTGRQHLGNYLGAMKNYVALQKDYDCIYCIVDLHALTTLETTRDLKQNTFEMALDWLAAGIDPRESIVFIQSHVPQVTELSLILSMVSPLGKLTDLPTFKEKVRMQPNNVNLGLVSYPVLMTADIVLYETDIVPVGIDQASHIEFARETVRSFHYRYNTTVLKEPEIKLTEVPKVLGTDGQQKMSKSLNNHIELALTPEETTKVVMTMVTDPQRQRRTDPGNPDVCNVFSMHKVFSSPEEVEMINTECRRAGIGCVDCKKRFAANLNASLAPFREKRAALAQNPDEIWDILHDGANRARVIAEQTMVKVREAVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ86</accession>
    <name>E8MZ86_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">gatA</name>
        <name evidence="10" type="ordered locus">ANT_01950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558627.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01950"/>
    <dbReference type="EnsemblBacteria" id="BAJ62229">
        <property type="protein sequence ID" value="BAJ62229"/>
        <property type="gene ID" value="ANT_01950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01950"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="9">
        <location>
            <begin position="52"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="527" mass="57072" checksum="82ABDADD26676557" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC3</accession>
    <name>E8MZC3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotriesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_02320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02320"/>
    <dbReference type="EnsemblBacteria" id="BAJ62266">
        <property type="protein sequence ID" value="BAJ62266"/>
        <property type="gene ID" value="ANT_02320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02320"/>
    <dbReference type="eggNOG" id="COG1735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054760_1_0_0"/>
    <dbReference type="OMA" id="CHMNPSH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="33672" checksum="B459CBC6DFA74E77" modified="2011-04-05" version="1">MNGGEPMPVLHTTLGALSAPPEGIILPHEHIFVDLRPLDAPNHGQAKTEDVVALMAPELKRARAAGIAALVECTPEGVGRHVEHVLAVSQAGNFPILVPTGIYREPWVPAWAHHADEGILQSWMMGDLEVGVGNTGVRAAFIKLSMGDDGITPVERKILRAAARAGAKTGAAIGSHTIRGRVVLEQIDELEACGFDPHRFISIHAQAEPDFALNLEVAHRGAWIEYDGIGWSEDEAYIRRILDMLEAGFEGQILLSMDRGWYDCAQPGGGTPHPFTYLVEVFLPKLRAAGVDEATLRRLTVENPFRAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE0</accession>
    <name>E8MZE0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hepar_II_III_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64488">
        <property type="protein sequence ID" value="BAJ64488"/>
        <property type="gene ID" value="ANT_24620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24620"/>
    <dbReference type="eggNOG" id="COG5360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022012_0_0_0"/>
    <dbReference type="OMA" id="WCAEHDG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="60"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="669" mass="77522" checksum="90625CC0E878E42D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE4</accession>
    <name>E8MZE4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560847.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64492">
        <property type="protein sequence ID" value="BAJ64492"/>
        <property type="gene ID" value="ANT_24660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24660"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_612405_0_0_0"/>
    <dbReference type="OMA" id="FIQGDHF"/>
    <dbReference type="OrthoDB" id="411451at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="469" mass="51789" checksum="35553A4DC5FE922B" modified="2011-04-05" version="1">MSLLPLGLLSMVEDSLAWDGLTVQVRSEPRLRATIHRLVEVSSLEKGERAAWARFLVRGASQSLGILPASIDGLYRARARGDVPATWTTPAFNLRVLPFEAARAVFRAARKLDAGAFIFEIARVELDWTGQSLAEYATAVLAAAIAEGYRGAVFLQGDHFQASAKRARWEEKTALEALIREAVLAGFFNLDLDASTLVDLSHDRVLDQQFDNAILTASLVAFARSFQPEGISFSLGGEIGEVGGHVTTEEELHAFMHLFRRGLHALAGDLAGLSKVSIHTGSAHGGIVLPDGSFAPVNIAFDAIQRLGEVARQSYGMGGVVQHGASTLPLEYFPAFVRYGTLEVHLATAFMNTFFEHLPEEYLKAVQAWLDARYQHERRAEQSDAQFYAGVRMHALAPFKETFLRLPEEIRQAVMQDWETQFVDLMERLGCAGTRALVERWVNPRPVPFYLEDYWLEASKPAGESDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG3</accession>
    <name>E8MZG3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">hutI</name>
        <name evidence="6" type="ordered locus">ANT_24850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560866.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24850"/>
    <dbReference type="EnsemblBacteria" id="BAJ64511">
        <property type="protein sequence ID" value="BAJ64511"/>
        <property type="gene ID" value="ANT_24850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24850"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041647_0_1_0"/>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="65"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="415" mass="45326" checksum="78FA4FE563D9F516" modified="2011-04-05" version="1">MLIHSAGQLLTLAGGVQRGKALGNLGIIEDGALLIRSEQIVDVGKTADLLAKYPAEPRLDAQGKVVMPGFVDPHTHLVFAGDRAAEFEMRLQGKTYLEILQAGGGILSTVRATRAASVDELVQQAAERAKIMLKHGTTTLEAKSGYGLEWQSELRQMEALLRLDSQGILEIHPTFLAAHAIPEEYHDFPSQYVEQICEVMLPELRRWWIRNADARPLPFVDVFCERGAFTLPQSRRILETARELGFPLKIHADEFENLGGVRMALELGAISVDHLVKTSPEEIALLGNSQTVAVSLPCTPFGLAEAEYTPARAILDANGILALASDFNPGTAWCGNMQFVIALACRYLKLTPAQAIAAATINAAAAIRQEKRIGSLEVGKQADILILSVEDYRHLGYRFGVNLVEHVIKRGKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ5</accession>
    <name>E8MZJ5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative M16 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25170"/>
    <dbReference type="EnsemblBacteria" id="BAJ64543">
        <property type="protein sequence ID" value="BAJ64543"/>
        <property type="gene ID" value="ANT_25170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25170"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_0_0"/>
    <dbReference type="OMA" id="FNGSTHL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="177"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="440" mass="49481" checksum="B543A9D7CC1A8D8F" modified="2011-04-05" version="1">MIHLTKGHMDSPTLFTKLANGLTVHLKEIHTAPLISHWVWYRVGSRNEVPGKTGLSHWVEHLQFKGTPRFPPSVLDKAISREGGVWNAFTYLDWTTYYETLPADRIGLALELEADRMINSVFDPAMVEAERTVILSELEGNENEPLFQLGRAVQQASFQHHPYRNEVIGNREDLLQITLEDLVQHYRQYYVPNNALIAIAGDFRLEEMLQRVREVYESLPAGEIPPRNIPVEPSPSGEKRLEVHGPGETAYIQVAYRALPAAHPDFAVLMVIDSLLSGPASLNMFGGGGISNKTSRLYRALVEKELAVGVGGGVQATIDPFLFEITITLPPVYHPDQTLRAFDEQIVRLMETPVTSKEIQRAIKQARALFAYGSENITNQAFWLGYAEMFDHYDWFVHYLDRLSQVTPMDVQRVAQQVLTPQGRVVGFYLPEGNLPGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM0</accession>
    <name>E8MZM0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">eno</name>
        <name evidence="13" type="ordered locus">ANT_25420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560923.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64568">
        <property type="protein sequence ID" value="BAJ64568"/>
        <property type="gene ID" value="ANT_25420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25420"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_0"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="140"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ64568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="435" mass="46967" checksum="702A1397CB5688E4" modified="2011-04-05" version="1">MDTIIESIVATEILDSRGNPTVEVEVVLADGSWGRAAVPSGASTGVHEALELRDGDKSRYLGKGVTKAVENVNTVIADELLGWDALEQKAIDQQLLALDGTPNKSKLGANAILGTSLAVAKAAANALGLPLYRYIGGVYAHVLPVPMMNILNGGAHTGWQSTDAQEFMVMPLGAPTFAEGLRWGAEVYHALKSVLKSRGYTTLVGDEGGYAPALKANVEAVEVILEAIQKAGFKPGEQIAIALDPAASELYDEETKKYNLRKEGKMLTGEELVAFWKSWIDQFPIVSLEDGLAEDDWDSWKLLTAELGDRIQIVGDDLLVTNPERVRRGIQEKAANALLVKLNQIGSLTETIEAVELCHRNGWRAVCSHRSGETEDSTIADLAVALNMGQIKTGAPARSDRVAKYNQLLRIEAELGDTAKYAGWDALRVRPPFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN8</accession>
    <name>E8MZN8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase ECF-type sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_25600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="BAJ64586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25600"/>
    <dbReference type="EnsemblBacteria" id="BAJ64586">
        <property type="protein sequence ID" value="BAJ64586"/>
        <property type="gene ID" value="ANT_25600"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_0"/>
    <dbReference type="OMA" id="NTWIFTI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="25"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="126"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="185" mass="21297" checksum="A7495CCEA3B124A4" modified="2011-04-05" version="1">MPETSTVPHLIVRAQRGSREATAQLYELYHDEIYRFLAYRTGDSDSAADLTGEVFLKMVEALPNYRSNGAPFRAWLYQIARNLAIDHFRRGKSHPQENLSENHQAVNETPEETVQSRSQVQELYIALQRLPEDQRDVLVLRFLNGLPLAEVARILHRSEDAIKGLQRRGLIALREEMKSLEVPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ1</accession>
    <name>E8MZQ1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_25730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64599">
        <property type="protein sequence ID" value="BAJ64599"/>
        <property type="gene ID" value="ANT_25730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25730"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356693_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="377"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="682"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="786" mass="87729" checksum="4B5F12F6E64D10E8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ4</accession>
    <name>E8MZZ4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558726.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02950"/>
    <dbReference type="EnsemblBacteria" id="BAJ62329">
        <property type="protein sequence ID" value="BAJ62329"/>
        <property type="gene ID" value="ANT_02950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02950"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031758_0_1_0"/>
    <dbReference type="OMA" id="YGLPRVN"/>
    <dbReference type="OrthoDB" id="1456605at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="113"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="412" mass="45877" checksum="D61DC059A8428BEE" modified="2011-04-05" version="1">MPEKYDLIIRRAQLRRTPAGQWFDIAIANGVIAAIAPHVDGSAAQELDAAGGLVTESFVNTHLHLCKVYTLQMMDEEALKDYHGADMGKAMTAIELAARVKEKYDERWIIQNVRRALVDAARYGNTHIRAFADVDSKAKLEGVKALIRAREEFRGIVDIQVVAFAQDGMVREPGARELMRQAMELGADVAGGIPWIEYTDADMLQHVREIFDLAVEFNKDVSMLVDDAGDPGLRSIEMMALETIRRGWFGRSLAHHARAMSMYPTPYFQKLAALLKKAQMGVVSDPHTGPLHARVRELLAEGCLVCLGQDDISDAYYPYGRNNMPEVAFLASHLLWFTTASDMETLYDMVTVNAARAIGLKDFALKVGAPAHLVVMEQQNVLEVLRYHEAPRYVISHGKLVDQQAVRNMAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N025</accession>
    <name>E8N025_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvB</name>
        <name evidence="12" type="ordered locus">ANT_03260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03260"/>
    <dbReference type="EnsemblBacteria" id="BAJ62360">
        <property type="protein sequence ID" value="BAJ62360"/>
        <property type="gene ID" value="ANT_03260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03260"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_0"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="194"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="388"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="573" mass="63478" checksum="2D72824094E128C7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N036</accession>
    <name>E8N036_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_03370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558768.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03370"/>
    <dbReference type="EnsemblBacteria" id="BAJ62371">
        <property type="protein sequence ID" value="BAJ62371"/>
        <property type="gene ID" value="ANT_03370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03370"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1993">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051799_0_0_0"/>
    <dbReference type="OMA" id="VHRHHTI"/>
    <dbReference type="OrthoDB" id="819754at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="127"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="286"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="365"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="427" mass="47256" checksum="D1487911E0A7809A" modified="2011-04-05" version="1">METPQTREGLRLRIYLGESDRWRGKLLYNAILDVLRQQKIAGATVLRGISGFGAHAYLRSTDLEVLSSDLPIIIEVVDTPEKIHNALETISPMVQEGMITLEEVRILKYTQRHLNPLPAERLVREVMTRDVVHLMPEMNVRQAWQKMLESGVKAMPVVDSERRVVGILTSEDLLERGVIRQRLSVAVRLDEAEIQEELRLLSASPLTVKDVMTQPVITAREDEHLGNAVRRMIDKGLKRMPVVNAGNQLVGMLSRLDILRQVSGSPTLPSSAAAVRGAVRTVGEVMRTDLPVIRLTERLDTLLEKFAACDSNRLLVVDEQNKPVGVISDSDVVVRVEAAQRKGILQALRRLTSPPPLKVTAEDLYSPGVLTVPTDAPIASAVQTMLAEGRKVLAVVDKQGTLLGIVDRQSLLEALFADFAEIPGNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N073</accession>
    <name>E8N073_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_03740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558805.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03740"/>
    <dbReference type="EnsemblBacteria" id="BAJ62408">
        <property type="protein sequence ID" value="BAJ62408"/>
        <property type="gene ID" value="ANT_03740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03740"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="AFIETRE"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="28126" checksum="D34AEFEE529BD9D4" modified="2011-04-05" version="1">MLEFQRVTFHYRHGTPIFLDFNWRVEKGDAWAVLGPSGCGKSTLLALAAGLLFPTQGQVLVEGQPLTRPRPHTGLIIQDYGLLPWATVRENAALGLRVRNFYGADGIHAPKDYVPRTDVTPWLERLGLLEVANQFPSQISGGQRQRTAIARTLALEPDLLLMDEPFSSLDAPTREGLQMLVMELWADQRLTLVLVTHAIEEAAMVGKRILVLGNPPNTQALVVDNPGAGEPNYRTTPEYQAICQFLREVLNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8N094</accession>
    <name>E8N094_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64643">
        <property type="protein sequence ID" value="BAJ64643"/>
        <property type="gene ID" value="ANT_26170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26170"/>
    <dbReference type="HOGENOM" id="CLU_3264883_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="41" mass="4662" checksum="D99FA0DBDEB0AE1D" modified="2011-04-05" version="1">MSLVDWKFPGLEFSLDALKNVLIEIILSGREICNFDTSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0A0</accession>
    <name>E8N0A0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">xseA</name>
        <name evidence="10" type="ordered locus">ANT_26230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64649">
        <property type="protein sequence ID" value="BAJ64649"/>
        <property type="gene ID" value="ANT_26230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26230"/>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023625_3_1_0"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="9">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="8">
        <location>
            <begin position="130"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="8">
        <location>
            <begin position="330"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="271"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="413" mass="45244" checksum="0CA850DB0FB20B63" modified="2011-04-05" version="1">MDMPSLFPTPALSVSELTRLIRSLLESEPALSEIWVAGEISNFTRAASGHVYFTLKDSGAALKCVIWRNAARTLRVPLQDGIAIEAFGSIGVYEQGGNYQFYVTAVRPAGEGYLYQQFLRLKAQLEAEGLFAEERKRPIPTFPRRIGVVTSPTGAALQDILNTLRRRYPLVEVILAPSAVQGEEAPLELVQALNALNRIPDLDVILLARGGGSIEDLWAFNDEGVVRTVAASRVPVITGVGHETDFTLVDFAADLRAPTPTGAATLATPDRAELLIQVERTLQRLNRLISQRVNLESARLNQLESRLQRASPVRRIEDNRQRLDNAILRLQNTAARLIAQRQAHLQALNAHLSALNPLAVLERGFALIEHPEGGILTRAAQAQAGETVRIRLADGALTAKVEHVLLKPEKGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0H4</accession>
    <name>E8N0H4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_26970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561075.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26970"/>
    <dbReference type="EnsemblBacteria" id="BAJ64723">
        <property type="protein sequence ID" value="BAJ64723"/>
        <property type="gene ID" value="ANT_26970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26970"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701397_0_0_0"/>
    <dbReference type="OrthoDB" id="1049666at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011429">
        <property type="entry name" value="Cyt_c_Planctomycete-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07635">
        <property type="entry name" value="PSCyt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="302"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="393" mass="43997" checksum="CF342F1907BB1C3C" modified="2011-04-05" version="1">MSEQTKTYQRFSVAQRIEHFVLILSFTLLALTGLPQKFFFSDISQWIIAAFGGIETIRIVHRVAATVFCLQAIYHLVVMGYKLYVLRLEASMLPGVKDLQDAIQWFLYNIGLRKERPKMPRYNFMEKMEYWAMVWGLVIMALTGFMLWNPIATSRALPGVVIPAAKAAHGAEAILAVLAIILWHFYNVHIKHWNWSMIKGTLSREEMEEEHALELEQIERGVIPQPPEPEVIRKRMRVFVPVASVVSVALAVGLIYFITFEETSITTIPRPHEEERQIIVLRSPTPLPTVLPTATPQPTSEADLISGALTWEGSIGKIMTARCGSCHGSLGALNIKNYPDLMKGGRSGTVIVPGDPQGSLLIQTVQGGTHPGKFSDEELQKVIEWIQAGAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0K7</accession>
    <name>E8N0K7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561108.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64756">
        <property type="protein sequence ID" value="BAJ64756"/>
        <property type="gene ID" value="ANT_27300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27300"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_4_0_0"/>
    <dbReference type="OMA" id="MITHAAH"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="271" mass="30515" checksum="C525E8C7EF3C9B97" modified="2011-04-05" version="1">MEDKSITYQNYRNLVVYFILAYAISWTIGIPLALAKQEIIQPIFPQWFHYFVAYGPMISALIVTWTSQGQQGLKELWGRIIKWRVGGIWWLVALSPLIIGFLVALVMNLLTNTKISLSELGEIHFLPPLGIGALFLWLVTFGIGEEIGWRGYALPRLQKDRNALYATIILAFFWALWHLPQFFYLFDTSIAIGWVIGLFAGAIVFTWLFNSAEGSILILAIWHGCFNYISASNAGNGLLAAVVSTIVMIWAIVVVFVYKPTTLSSKGKFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0X3</accession>
    <name>E8N0X3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_04840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558914.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04840"/>
    <dbReference type="REBASE" id="32150">
        <property type="entry name" value="M.AthUNI1ORF4840P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62518">
        <property type="protein sequence ID" value="BAJ62518"/>
        <property type="gene ID" value="ANT_04840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04840"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_3_0"/>
    <dbReference type="OMA" id="WVKDAAW"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="167"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="391" mass="45562" checksum="625F0D2CD9C7EA05" modified="2011-04-05" version="1">MADYKSIQLTNFEVDKKVLDIVNNCLSQQPDPRPFVEINSIGYVFYFHTLDIKLLQRNIEMLTAHDLFSANNPSSSRKAGELLQKIYEEVSKIGSYGIRSGKRQYVNFDIERKVRNRKAKEQNRSQYYYAQDNNFSKISNQLPPEMTNQIFCGDSLEVLKKIPDNSIDLIFTSPPYNFGLEYERQDDAHKWDLYFEKLFAIFDECIRVLKFGGRIAVNIQPLFSDYIPSHHLISNFFISRRMIWKGEILWEKNNYNCKYTAWGSWKSPSNPYLKYTWEFIEIFAKGTLKKSGDPKNADITSDEFKEWVVAKWSIAPERKMKEFGHPAMFPEKLAERVIKLFSFVGDIVLDPFNGVGTTTAVAQKLGRKFIGIDISQEYCDIAQKRLKNTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N176</accession>
    <name>E8N176_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561166.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27930"/>
    <dbReference type="EnsemblBacteria" id="BAJ64819">
        <property type="protein sequence ID" value="BAJ64819"/>
        <property type="gene ID" value="ANT_27930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27930"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_21_2_0"/>
    <dbReference type="OMA" id="AYTLQIV"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="148"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="304" mass="32364" checksum="EAF96D088CEE5608" modified="2011-04-05" version="1">MWRSNALLLVVTAIWGMGFVAQRLGMEHVGVFTYNALRFGMGVLALFLFLPLVRRFEPLRAKASPRTLLKASLLAGGLMFIASTLQTEGLAYTTAGKAGFITGLYVVLVPLLGLVWGQRTHAATWVGAVLAVAGLYLLSVNEALQVSRGDWLVLASAFFWAAHIQALGFLTQKADPVYIAIGQFVVVTLLSLPGMLGWERPALAEISSAGGAILYGGLMVVAVSFTLQVIAQRDAHPAHAAVIMVMESVFAVLAGWLVLGESLSLRGFFGCTLMTAGMLLSALAPHLHARMGLSALQVKAGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N184</accession>
    <name>E8N184_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561174.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28010"/>
    <dbReference type="EnsemblBacteria" id="BAJ64827">
        <property type="protein sequence ID" value="BAJ64827"/>
        <property type="gene ID" value="ANT_28010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28010"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043773_1_0_0"/>
    <dbReference type="OMA" id="KYFTRYV"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="447" mass="50639" checksum="DC2DD14717EAEBDF" modified="2011-04-05" version="1">MSIFDGQRLDNRTFKLDIERMRRGWYSDKYFVNIAVMLNELSRRKYLYRGDKPNLPPHMAPNDLLVGDIEVEMQWFTRRPGTTIVVGVDKALTMLKHCTGYWDGDHFVDTHEQLEVWAVHDGALVHYNGDPLNITPVMRVRGRYRDFAMLETPTLGILTRASRVATNVYETLIAARGKPVLFFPARFDVHEVQAADGYAYNIAVQRFNMDYASTLGPFVSTDAQGDWWGGYGGGTIAHAAIASFLGDTAEAMLAFSEVLPKSIPRIALVDFNNDCVGDSLRVCRKMFDRYRALIEEGKPDEAERYRLYGVRLDTSGSLRDISVPPLGDPDLDLGVNPRLVFLVRQALDNAAETWDVPPEWVERAREYCRGVKIVVSGGFNPDKIRRFEKLGVPVDIYAVGSSLFNNHGPTVTDFTADVVRVKVHGEWVDMAKVGRRPRDNPEMERVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N189</accession>
    <name>E8N189_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ordered locus">ANT_28060</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561179.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28060"/>
    <dbReference type="EnsemblBacteria" id="BAJ64832">
        <property type="protein sequence ID" value="BAJ64832"/>
        <property type="gene ID" value="ANT_28060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28060"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_0"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAJ64832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="248" mass="27767" checksum="B3F8869A4116BD53" modified="2011-04-05" version="1">MRFDVFTLFPGLIEPYINESILERARMRGLLEVHVHDIRAYATDRHHVTDEPPYGGGGGMVMKCEPIFNAVESVLGAPPACPVILLTPQGRVFTQQVAMELSQYPHLALLCGRYEGVDERVREHLVTDEISIGDYVLTGGELPALILMDAITRLIPGALGDPDGAIDDSHASGLLEYPHYTRPAEFRGWKVPEVLLSGNHAEIARWRRRQALLRTLQRRPDLLEKAPLSEEDRKFLEQVRKSPDESGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1B0</accession>
    <name>E8N1B0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpsU</name>
        <name evidence="5" type="ordered locus">ANT_28270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561199.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28270"/>
    <dbReference type="EnsemblBacteria" id="BAJ64853">
        <property type="protein sequence ID" value="BAJ64853"/>
        <property type="gene ID" value="ANT_28270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28270"/>
    <dbReference type="eggNOG" id="ENOG502ZTRA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203308_0_0_0"/>
    <dbReference type="OMA" id="YTKMAEM"/>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="67" mass="8203" checksum="F5F0EEA928A0D72F" modified="2011-04-05" version="1">MTIVVLRPNESQDQLLKRFRKKVVKSGVLSTVRRKRWFVSKSELRRVEKKKALRRLKRRQYTKMAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1D3</accession>
    <name>E8N1D3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRISPR type III-B/RAMP module-associated protein Cmr5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_28500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR system Cmr5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561221.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64876">
        <property type="protein sequence ID" value="BAJ64876"/>
        <property type="gene ID" value="ANT_28500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28500"/>
    <dbReference type="eggNOG" id="COG3337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120836_2_1_0"/>
    <dbReference type="OMA" id="YVKKMPS"/>
    <dbReference type="OrthoDB" id="2028297at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023101">
        <property type="entry name" value="AF1862-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010160">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09701">
        <property type="entry name" value="Cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158568">
        <property type="entry name" value="SSF158568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01881">
        <property type="entry name" value="cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="125" mass="14295" checksum="87221447B901489A" modified="2011-04-05" version="1">MAETISKQRLLEQERASHAYDAVVKAKGKKDKELKSLARSAPASIQSNGLGQTLAFWKAKNEEHHLALYHALSGWLKKQLHIDENRDLLEWIATTADSLQYRQATAEALAYLNWYKRFAEAELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F1</accession>
    <name>E8N1F1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminoglycoside N(3)-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_28680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-acetyl-2-deoxystreptamine antibiotic + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12665"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57921"/>
            <dbReference type="ChEBI" id="CHEBI:77452"/>
            <dbReference type="EC" id="2.3.1.81"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the antibiotic N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.81" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28680"/>
    <dbReference type="EnsemblBacteria" id="BAJ64894">
        <property type="protein sequence ID" value="BAJ64894"/>
        <property type="gene ID" value="ANT_28680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28680"/>
    <dbReference type="eggNOG" id="COG2746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060091_0_0_0"/>
    <dbReference type="OMA" id="HATDCRL"/>
    <dbReference type="OrthoDB" id="1018324at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046353">
        <property type="term" value="F:aminoglycoside 3-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003679">
        <property type="entry name" value="Amioglycoside_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11104">
        <property type="entry name" value="PTHR11104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02522">
        <property type="entry name" value="Antibiotic_NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="291" mass="32077" checksum="55B380E009E71037" modified="2011-04-05" version="1">MVKVYALMSAFLYNGDTSFPKECLMGSLPPISIAELTRQLLDLGVKPGGVLVVHCAFSRVKPVEGGPLGLITALQQALGEEGTLVMPSMTDDDELPFDVRSTPCRDMGIVADTFWRLPGVLRSDSPHAFAAWGAEAAFITVPHPVEIPHGLDSPVGRVYQRDGQVLLLGVGHTENTTIHLAENLAGVRYRRRKRACLLRDGATIWVEYGEVDHCCQNFALVDGWLDAVHAQRRGRVGYAEARLCRARDVVHIVMEHLRDNETIFLHPLGVDEQCDEARLSLLSASDFPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H1</accession>
    <name>E8N1H1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">rbsK</name>
        <name evidence="13" type="ordered locus">ANT_05420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558972.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62576">
        <property type="protein sequence ID" value="BAJ62576"/>
        <property type="gene ID" value="ANT_05420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05420"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_0_0"/>
    <dbReference type="OMA" id="IPWRDEL"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="4"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ62576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="303" mass="31523" checksum="6D1AC3B5EEFAF5D3" modified="2011-04-05" version="1">MSGTLVIVGSLNMDLVVRAPRHPQPGETLIGSSFQTFPGGKGANQAVAAARLGAKVRMIGRVGQDAFGDALLATVQRDGVDTTFIRRDPQAPTGVALITLDAKGQNTIVVASGANGNVSAEDVRQSAQAFEGADVLLVQLECPLEAVQTAVQLAHQAGIIVVLNPAPAQPLPAELLQMVDYLIPNQHELTLLAGGISDREQAIRHLQAQGVRYLVVTLGEEGALLALGEDRLILPAYPVEVVDTVAAGDAFAGAFALALAEGKTPLDAACWGNAAGAIAVTRPGAQPSLPTRQEVEQFLKERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1J0</accession>
    <name>E8N1J0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-mannosidase</fullName>
            <ecNumber evidence="10">3.2.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_05610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558991.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05610"/>
    <dbReference type="EnsemblBacteria" id="BAJ62595">
        <property type="protein sequence ID" value="BAJ62595"/>
        <property type="gene ID" value="ANT_05610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05610"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_2_0"/>
    <dbReference type="OMA" id="KRQWKGP"/>
    <dbReference type="OrthoDB" id="245411at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glyco_hydro_2" evidence="7">
        <location>
            <begin position="193"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase_ig" evidence="9">
        <location>
            <begin position="655"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_mannosidase" evidence="8">
        <location>
            <begin position="748"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="830" mass="95470" checksum="09BEBF2FDF54CF32" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1J2</accession>
    <name>E8N1J2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558993.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05630"/>
    <dbReference type="EnsemblBacteria" id="BAJ62597">
        <property type="protein sequence ID" value="BAJ62597"/>
        <property type="gene ID" value="ANT_05630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05630"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379973_0_0_0"/>
    <dbReference type="OrthoDB" id="1714795at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="94" mass="10027" checksum="821AB07808254063" modified="2011-04-05" version="1">MKVTVELTGAARAHAGVKTLSLDLPDTATYRDIVRELAKHFPQLVGWLIAPDGESFLSSNMLVINGDLATPVMVLDENPADGEHLILMSVITGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1K5</accession>
    <name>E8N1K5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559005.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05760"/>
    <dbReference type="EnsemblBacteria" id="BAJ62610">
        <property type="protein sequence ID" value="BAJ62610"/>
        <property type="gene ID" value="ANT_05760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05760"/>
    <dbReference type="HOGENOM" id="CLU_2091699_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="116" mass="13117" checksum="7F8E03BBEC671C7F" modified="2011-04-05" version="1">MKIDWGTVVVGLAILVVYGRMALIRGRKRRLERQALLEQKREAKKQKNRPHTPVAQPQPGIKITYEVVSWWLVGGGLLVTLAGIAMRYSALFPPAVQPYWWVVTAAGILLFAFSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1L7</accession>
    <name>E8N1L7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">suhB</name>
        <name evidence="7" type="ordered locus">ANT_05880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559017.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05880"/>
    <dbReference type="EnsemblBacteria" id="BAJ62622">
        <property type="protein sequence ID" value="BAJ62622"/>
        <property type="gene ID" value="ANT_05880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05880"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_4_0"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="265" mass="29670" checksum="80D8A97F273298AD" modified="2011-04-05" version="1">MLPELEDLKQFAREAGAVLLEGFGRKMAVEYKARINPVTEYDRRSEDLLIRLIRSRFPHHAILGEENGHQDGQKEHLWIIDPLDGTTNFAHGMPIFAVSIAYAYKGQVQLGVVYDPNQDDLFCAERGQGAWLGDRRLQVEGAGDLLHSLLITGFAYENWVIETNLQFFAHFHRRCEGVRRLGAAALDLCYVAANRADGYWEVSVNPWDLAAGGLVAEEAGARVTRMDGAPDYLRPPCNVLCANPVLHEIMLKEIQSVAVPLYPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1M3</accession>
    <name>E8N1M3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase component II</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trpG</name>
        <name evidence="2" type="ordered locus">ANT_05940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559023.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05940"/>
    <dbReference type="MEROPS" id="C26.955"/>
    <dbReference type="EnsemblBacteria" id="BAJ62628">
        <property type="protein sequence ID" value="BAJ62628"/>
        <property type="gene ID" value="ANT_05940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05940"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_0"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="194" mass="21436" checksum="97EF7328DA6D3AE3" modified="2011-04-05" version="1">MLLILDNYDSFTYNLAQIFGELGEEIAVYRNNEISLEQIRALQPERIVISPGPGGPEDAGVSIEVIRELGMHIPLLGVCLGHQCIAAAFGGNVTRAPRLMHGKTSPIYHYGEDLFTGIPSPFEATRYHSLIVAEPLPQELKATAFTSAGELMGLRHRQYPIFGVQFHPESILTPYGKQLLRNFLDVRVPAAQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P9</accession>
    <name>E8N1P9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06200"/>
    <dbReference type="EnsemblBacteria" id="BAJ62654">
        <property type="protein sequence ID" value="BAJ62654"/>
        <property type="gene ID" value="ANT_06200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06200"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677301_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="70"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="406" mass="44955" checksum="BB26C1E7557D23DF" modified="2011-04-05" version="1">MREHMKRIFLFLSLILWVFIAIAQTPLPEEVIGEPVMLDTPSQPGLLFTGCTRVNVAPMNDAYEHRVVELSNIERDKLGIPPLKRNTDLDYAGRFHSKDMMDEDYFDHNSYDGETQVCLWYTRVGNFYTGYSSLAENIAAGHSTPEAVVEAWMNSPGHKANILDSNYREIGVGYTYGGGTYYRYWTQDFGTRSSVYPIVINLEAAQTASPDVNLYIYGKGKWSEMRLRNDSGTWTAWMPFQERVNGWSLPWIAGTRTVSVELRSGTTTTSASDTITLTTSGNRLGNLPDSITFLYDKSTGTLYPSASLALQPTNSLNSTPLTWSAAVNPTSNFLQLSRTSGTTPNDTLLVMPHASTLQNVGTTLGTLTIAITNPVYPPEGSSKTIPVRVSVVNSLNARVYLPAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T0</accession>
    <name>E8N1T0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559080.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62685">
        <property type="protein sequence ID" value="BAJ62685"/>
        <property type="gene ID" value="ANT_06510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06510"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488889_0_0_0"/>
    <dbReference type="OrthoDB" id="1733394at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="549" mass="62956" checksum="3487178E1AA9FE36" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V1</accession>
    <name>E8N1V1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06720"/>
    <dbReference type="EnsemblBacteria" id="BAJ62706">
        <property type="protein sequence ID" value="BAJ62706"/>
        <property type="gene ID" value="ANT_06720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06720"/>
    <dbReference type="eggNOG" id="COG3877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132137_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018658">
        <property type="entry name" value="DUF2089"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09862">
        <property type="entry name" value="DUF2089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="174" mass="20121" checksum="CAA3A69BA65D7547" modified="2011-04-05" version="1">MNFQKREWMKDGGAYMNPMLTKCPVCGGELVVTRLACPSCETTIEGHFQTMGGGLQGAFSAEQLRWLLPFTRLNNEQMQFILTFIRCEGRFNRMEEELGLSYPTLRNRMNEILRTMGYEPSREEGQPAPVKLSPEERKRILDDLDKGLITLQEAKRRLKGIREESKRENEVSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X8</accession>
    <name>E8N1X8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgC</name>
        <name evidence="7" type="ordered locus">ANT_28990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561270.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28990"/>
    <dbReference type="EnsemblBacteria" id="BAJ64925">
        <property type="protein sequence ID" value="BAJ64925"/>
        <property type="gene ID" value="ANT_28990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28990"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_4_0"/>
    <dbReference type="OMA" id="QEWDVDE"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="424" mass="47669" checksum="170190F529617885" modified="2011-04-05" version="1">MPSLDQVLAVILGGGRGSRLYPLTKLRSKPAVPMAGKYRLIDIPISNCINSRIYRIAVLTQFNSHSLHRHITQTYHFDVFHTGWVQIWAAEQTMEHTDWYQGTADAVRKQLLQIRATRAEYVLILAGDHLYRMDYDKMAAFHWEHNADITVAVQPVRSEDAPRFGILKRGADGRITDFAEKPKDPQRLAELVSRDDPARPYLGSMGIYFFKTNILAGLLENNDFDDFGGEVIPYALKHYQVYGYDFSGYWEDIGTIRSFYETNLALANPNPAFKLYDPDRPIYSRPRFLPGTIAENCILENVLLAEGCCIKNAEIRHSVIGLRSQIRSGTVIRDSILMGADYYDRACSDECESEGETPAIGIGRNCHIEGAIIDKNARIGSNVVIKPFPRRTDRDMGLYVINDGIVVIPKDAVIPSGTVIAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Y0</accession>
    <name>E8N1Y0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561272.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29010"/>
    <dbReference type="EnsemblBacteria" id="BAJ64927">
        <property type="protein sequence ID" value="BAJ64927"/>
        <property type="gene ID" value="ANT_29010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29010"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_0_0"/>
    <dbReference type="OMA" id="AMTQQMK"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="301" mass="33657" checksum="6B0D7A3AC2BF5D33" modified="2011-04-05" version="1">MDAAQLTLLCLIGGIGFIVLIFLWNAIKVVPEYKRLVVFRLGRCIGDRGPGLVLLIPIIDRAVWVDMREQVREIPQQTAITKDNAPISIDFLWYYKVLSPTDSVLQVGNFEVAAQGMATTTLRAVIGGILLDDVLSERETINNILRTRLDEVTGRWGVKVTNVEIREIIPPREVQEAMNRQMSAERIRRAVVTESTGTREAAINVADGERQSAILRAEGEKQSAILRAEGEKQAQLLRAEGYAAALERIFSVAQTIDQKTLTLQYFETLKSMAQSPSTKYIFPMEFTSLLSSFISGQEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Y6</accession>
    <name>E8N1Y6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29070"/>
    <dbReference type="EnsemblBacteria" id="BAJ64933">
        <property type="protein sequence ID" value="BAJ64933"/>
        <property type="gene ID" value="ANT_29070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29070"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_1_5_0"/>
    <dbReference type="OMA" id="QYGIVRW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="62"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="152" mass="16597" checksum="0DBAC10AF179B415" modified="2011-04-05" version="1">MARKKPVQTKKTAQRQGFPWWAWVLIGLVVGFGAIAVSTLMRPSQQATLPAEISVQQAAQLRDEGAFVLDVREPEEWNEYHIPGATLIPLGQLASRVNELPRDQKIVVYCRSGNRSQEGRDILKQAGFTNVTSMSGGIKAWSAAGLPTVTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Y9</accession>
    <name>E8N1Y9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561280.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29100"/>
    <dbReference type="EnsemblBacteria" id="BAJ64936">
        <property type="protein sequence ID" value="BAJ64936"/>
        <property type="gene ID" value="ANT_29100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29100"/>
    <dbReference type="eggNOG" id="COG1656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074576_0_0_0"/>
    <dbReference type="OMA" id="VPHTEVD"/>
    <dbReference type="OrthoDB" id="1234999at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="85"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="235" mass="27523" checksum="1DF1BF1BF02158BB" modified="2011-04-05" version="1">MPGAWFAFHPDLWMLLPHARRREVFWLDFQGHQSLKHLIESLGVPHTEVGEVRRNGQPVGLSRTPAEGDRIEVFPAEPQSLPIPPRFVLDNHLGRLAAYLRMLGYDSLYRNDFADEELAQIAVQQERILLTRDRRLLMRKGIQYGHWVRSQNPREQVAEVVRRFCLNHRQGAFQRCLRCNTPLEAVSKESVLEQLEPLTRLYYDEFHRCPSCGQVYWKGSHYERMLDLIENLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N211</accession>
    <name>E8N211_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlD</name>
        <name evidence="4" type="ordered locus">ANT_29320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561302.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29320"/>
    <dbReference type="EnsemblBacteria" id="BAJ64958">
        <property type="protein sequence ID" value="BAJ64958"/>
        <property type="gene ID" value="ANT_29320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29320"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_0_0"/>
    <dbReference type="OMA" id="AGETTWH"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="297" mass="33321" checksum="AB35C22921EDBECC" modified="2011-04-05" version="1">MRILLLGHGGQVGWECRRTLAPLGEVVTADYPEVDFAQPEGLPALMERVRPQVIVNAAAYTAVDRAESEPETARRVNALAPGVLAQSARRLRAALVHISTDYVFDGRKGAPYTEEDIPNPLSVYGQTKWEGEQAVQEAGGAYLILRTSWVYSLRRESFVSKVLEWSRQKDVLRVVDDQVAGPTWARMLAQAISAVLAQSLASGDIFDWLEERRGVYHLAGKGWCSRYQWACEILRLDPHREQQRAREILPARTAEFPTPAVRPLFSALEMSKFERTFGLTLPLWSQALEMAMEGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N217</accession>
    <name>E8N217_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_29380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561308.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29380"/>
    <dbReference type="EnsemblBacteria" id="BAJ64964">
        <property type="protein sequence ID" value="BAJ64964"/>
        <property type="gene ID" value="ANT_29380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29380"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158538_0_0_0"/>
    <dbReference type="OrthoDB" id="2030126at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZANK-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="139" mass="15947" checksum="DAB94CBB6D10F826" modified="2011-04-05" version="1">MITHFCPHCWAEIPAKSVVCPHCGADLSGFEAETFEDKLLEALHHSLPERRIMAAQILGNIQSRRAVPLFEQILQSEEKDFFFLRAVLLSLAKINPPQCRLWLERAAQHPSILVSRFAQELLARLDRGQPLDEWERHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N231</accession>
    <name>E8N231_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561322.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29520"/>
    <dbReference type="EnsemblBacteria" id="BAJ64978">
        <property type="protein sequence ID" value="BAJ64978"/>
        <property type="gene ID" value="ANT_29520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29520"/>
    <dbReference type="eggNOG" id="ENOG50336UF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1863529_0_0_0"/>
    <dbReference type="OrthoDB" id="1994870at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="164" mass="19150" checksum="8709578999B3FCD5" modified="2011-04-05" version="1">MTAQIPENLIYEGYRTTMNFCPFLPKDHPRIVELSGEEIQRENIHPMIFSTACWREYVGTWEVKNGQFYLVRLTGKYKILGDDPIPADWFSGVLKIPVGKILHYVHMGFGTVYEREILVTIDKGKVVNVRIKDNRGKEIDHWNQVERSMPGSEFRSEDEDDSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N257</accession>
    <name>E8N257_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-galactosidase</fullName>
            <ecNumber evidence="6">3.2.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_29780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561348.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29780"/>
    <dbReference type="EnsemblBacteria" id="BAJ65004">
        <property type="protein sequence ID" value="BAJ65004"/>
        <property type="gene ID" value="ANT_29780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29780"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007853_7_2_0"/>
    <dbReference type="OMA" id="RAHPDTW"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="5">
        <location>
            <begin position="11"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ65004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="583" mass="66422" checksum="D2EF646562D10FB8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N287</accession>
    <name>E8N287_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_30080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561375.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30080"/>
    <dbReference type="EnsemblBacteria" id="BAJ65034">
        <property type="protein sequence ID" value="BAJ65034"/>
        <property type="gene ID" value="ANT_30080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30080"/>
    <dbReference type="HOGENOM" id="CLU_745238_0_0_0"/>
    <dbReference type="OMA" id="CFAAMER"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ65034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="371" mass="40665" checksum="724D9F03669D5A34" modified="2011-04-05" version="1">MPSSPSLRLPRGLILLGALILWLATAYFAYHAWVHGADHRDFYPRWAGVRRVLAGERDLYSAEATRAMQIQLYGAPIPAGRDQQGFAYPAQLAVLLLPFGLIPDVEIATALWQGLSLLMLAGAFWALRASVSHRLPPGLLLALAVWNYPLLMLFQGQITALLCIILAGAAALFLRRRDALAGAVLALGVVKPELIALPALAFLWLAVRERRWRFLWGLAGGSLGLFLVSVALAGWWIPGWLNGLSAYAGYARVVWAPAELWRMHPAMALGVLAFALGMVWRGRQSLWGLLGAGIPAGMLVFPQTLLWGLTLLTLPLLLAYRRGGRAAVWLIWILGWTALFIQPLAEWWKVQAVGMPVLTLGALWLADAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A4</accession>
    <name>E8N2A4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561392.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30250"/>
    <dbReference type="EnsemblBacteria" id="BAJ65051">
        <property type="protein sequence ID" value="BAJ65051"/>
        <property type="gene ID" value="ANT_30250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30250"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054001_0_0_0"/>
    <dbReference type="OMA" id="AIAGQCY"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="420" mass="46624" checksum="05353C5519A8A2EE" modified="2011-04-05" version="1">MAHPLIATLKNARGNARGAILSEPLWGIPFNLYAPYFSVYMLALGLTDSQIGLLVSLGLVFQFFWGLLGGIITDKLGRKRTTFIFDAISWTIPTLLWATAKSFYSFLAAVPFNSAWRVTHNSWTLVLVEDTDPEELVEIYSWIYIAGQLAVFFAPIAGLLIARFGLVPTMRGLLLLACVMMTAKFIVMNAMVTETQRGKIRMEETRHRSIFSLLLEYRDVLGILFRSPATLYTLGIHLAFSIANTVSGTFWSILVTEKLLIPAAHLSLFPIAKSAIMLMFFFLITPRLRGVHFRNPMVLSFLGYIVAYSILLVTPERNYPLLFLSVTIETCSFAVLGTQLDRLLVVTMNPEERARIMALFVATLVAATSPFGWIAGALSSINRILPFLLCLAMYAIGIVLVLRAARLPQNQPQTGEVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2D6</accession>
    <name>E8N2D6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_07080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559136.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62742">
        <property type="protein sequence ID" value="BAJ62742"/>
        <property type="gene ID" value="ANT_07080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07080"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_0"/>
    <dbReference type="OMA" id="DQALDIC"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="294" mass="33216" checksum="BE6FD779B1E31C9C" modified="2011-04-05" version="1">MDIKQIVYFLAVVDTGSFSAAAEELYISQSSLSKQIIALEKELGFLLFDRSKRKISLTSAAKVFLPHARRIKDEYYSMLANVAPFKASPSLSIIAIPVIAQYGIPSYIAQFKQAYPTVQLIVEEREASVILPALSSHQFDLAFVRDNYLDRSQFDYIIVARDKLKAILPRHHRLAERKQISLNELSNENFIMFDKGTVVHELIMDACRSAGFEPRIFYASLRVESILGLVASNSGVALMMEKVVEYHRHPNVVDVPLAETISSNLVLAWSKHHQLSEEAKSFITIIQKDSNRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I6</accession>
    <name>E8N2I6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559185.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62792">
        <property type="protein sequence ID" value="BAJ62792"/>
        <property type="gene ID" value="ANT_07580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07580"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027829_2_3_0"/>
    <dbReference type="OMA" id="INWGRYG"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="437" mass="48745" checksum="BCEE546477772A42" modified="2011-04-05" version="1">MNLNPQIPLVELKNVQQVYGSGARRFTAIQDVNLIIREGEFVALLGPSGCGKSTLLRIITGLQSPTSGQVLYRGTPLHDVNPYATIVFQTFALFPWLTVFENVDLALKVRGVAAEVRKNRALELLDKVGLDGFETAYPRELSGGMRQKVGFARAIAVEPELLCLDEPFSALDLLSAESLRGELMELWLSGAIPTRAILMVTHNIEEAVFMADRVILMDKEPGRVVGSLDITLPHPRQRKSPAFQAVVDQVYAALAGQTQPEVIELGSAPGEPGTTRRLPQVRINELTGLLEHLVELPGKREDIYRLAEPLGADSDHLLELLEAEELLGFVRVQQGDVLLTDLGETFAEARILARKEIFATRIRRLPIFRWLLSMLRAADQQRLEWDVVQAALELEFPPDEAEHQLDTIVDWGRYAEVLAYDDKEGMIYLEAEVVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L1</accession>
    <name>E8N2L1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559210.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07830"/>
    <dbReference type="EnsemblBacteria" id="BAJ62817">
        <property type="protein sequence ID" value="BAJ62817"/>
        <property type="gene ID" value="ANT_07830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07830"/>
    <dbReference type="HOGENOM" id="CLU_876168_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="317" mass="33730" checksum="90505B804E6FF935" modified="2011-04-05" version="1">MDESALERLSAEQLAGLSDEQKAVFCTLTPQDQDFFARTFSPKDLPGALTRKGEIMKRHAEERERLAAMLEALRKGAQEHQPVEDEAGGTLTALAAGVLGVGAVAAVATDGSASYQGVKPDDFIAPLQAEFNGRGSLITFSGDNQNLTGTISLITNAGAIPALTITLARTPSGCDVKVNDLTRPGMLEIVKQGGKRLLGLAGAGISLLRGDVRGVDDLFDKASRALSEGAGLAEIAGHLQLKERAWKVIRQTAEALEAAYLKQKEAKRAERLALERAWDAYYACPTCSVPFGDGDTECRVCGSARPAQPSQPDPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2N6</accession>
    <name>E8N2N6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_08080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559234.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62842">
        <property type="protein sequence ID" value="BAJ62842"/>
        <property type="gene ID" value="ANT_08080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08080"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OMA" id="IVTVWQY"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="111"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="384" mass="43671" checksum="99D516CE7B68C2D1" modified="2011-04-05" version="1">MLRNPYLDTLITAGLTVLFIILTSYGLAALARQIQRWRGASPKLQQDTFAGYLFAAPWITGFLIFVVFPLAASLYWSFTDYRIAAGVSPKWVGFSNYLHLLLKDTNFRASIVNTLFLVVVGLPLQIGVALFLAVILNQKARGEKVFRMAFYLPVILGFNAAVLLCWRLMLNTGTGIINQILRAISRAFPPFDYLLRAGIFVQELISAVFLGIGSGKFNLLMKIWEAGFPPPNRVPLWIQSPLWSKTSVILLMIWGCGAMMMIFLAGLNNIPRELHEAAEVDGATRSQRFWKITFPLLTPYIFYNLVVGTINTLQIFEPIYVLYRDNQPLVPSAISMVYYLWQVSFRHFEIGMGSAISWLIMILILIVTVIQFRLQNRWVTYELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2R1</accession>
    <name>E8N2R1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561402.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30350"/>
    <dbReference type="EnsemblBacteria" id="BAJ65061">
        <property type="protein sequence ID" value="BAJ65061"/>
        <property type="gene ID" value="ANT_30350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30350"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494917_0_0_0"/>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="550" mass="59664" checksum="1D66CACBB6F8FE73" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y2</accession>
    <name>E8N2Y2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_31060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561473.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31060"/>
    <dbReference type="EnsemblBacteria" id="BAJ65132">
        <property type="protein sequence ID" value="BAJ65132"/>
        <property type="gene ID" value="ANT_31060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31060"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_9_5_0"/>
    <dbReference type="OrthoDB" id="1669868at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="213" mass="23224" checksum="D628CD115A643A00" modified="2011-04-05" version="1">MQTPPIQALLFDVGGVILRTEDPAPREALARQYGMSRADLEKLVFASPAALAAERGEADEPAVWDFVARTLRLSAPQLTAFREQFWAGDRVDTALLAFLAEARPRVRTGLLSNAWTRDLRALLCAFGAPADLLDRAVEVWLTSSMLGARKPDPRAFAAALAHLGASAGQTVFVDDFVENVEGARRAGLVGVHFQTTAQALETLRRLLENAWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Z7</accession>
    <name>E8N2Z7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_31210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31210"/>
    <dbReference type="EnsemblBacteria" id="BAJ65147">
        <property type="protein sequence ID" value="BAJ65147"/>
        <property type="gene ID" value="ANT_31210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31210"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358132_0_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="93"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="639"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="782" mass="88525" checksum="E1423675617A5A44" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N307</accession>
    <name>E8N307_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_31310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561498.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31310"/>
    <dbReference type="EnsemblBacteria" id="BAJ65157">
        <property type="protein sequence ID" value="BAJ65157"/>
        <property type="gene ID" value="ANT_31310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31310"/>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_3_2_0"/>
    <dbReference type="OMA" id="WGATILP"/>
    <dbReference type="OrthoDB" id="1264541at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="63"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ65157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="272" mass="30384" checksum="CA35AB75C2854A14" modified="2011-04-05" version="1">MPQGQTIPLRQRLLSWFFLLLGALYFFLPLVATLEFSMRAKKGVLSFLAYERVLRDPKFVQAFTFSLELALLTVIVAVILVVPTAYWIRLRLPQLRPIVEFITLIPFVVPAIVLVFGLIRVFSRPPLLLTNSETGTQILLIAGYVVLVLPYMYRAVDTGLQALDIRTLTEAAQSLGADWWTIITRIIFPNLRSAILSGAFLTITIVMGELTMASFLVGLRAFGPYMSQVGQNRAYEGAALAVISFLLTWAFTTLFQFVGRRALGGDQTFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8N347</accession>
    <name>E8N347_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_31730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561537.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31730"/>
    <dbReference type="EnsemblBacteria" id="BAJ65197">
        <property type="protein sequence ID" value="BAJ65197"/>
        <property type="gene ID" value="ANT_31730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31730"/>
    <dbReference type="HOGENOM" id="CLU_2010504_0_0_0"/>
    <dbReference type="OrthoDB" id="2101468at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="123" mass="13523" checksum="0C4B4278C23FAFE7" modified="2011-04-05" version="1">MRTVRFLFFLLSIAAGIGLGLAYGWLIKPPDPTQLTPQVLRADFKADYVLMVAQVYQRDQNLAQAVQRLSRLDPQSPARAVAEALLTARDLQYDPADLQVMSDLARALQMLETPAVPTGEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N351</accession>
    <name>E8N351_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561541.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31770"/>
    <dbReference type="EnsemblBacteria" id="BAJ65201">
        <property type="protein sequence ID" value="BAJ65201"/>
        <property type="gene ID" value="ANT_31770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31770"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1149998_0_0_0"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="1">
        <location>
            <begin position="53"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="241" mass="28575" checksum="266E75F61EDA1CA6" modified="2011-04-05" version="1">MLRELEAYYQKEGIYPLDFHCPYLSVCRKDNENFIEAKSAFVGSEYEKGTLPRLLFLSLDPGSSERDASRRTPEAVRYQEEHECNTDTLVKSRHWYRTHEMAWRLLKKFKPNLDIQSSHLYFAHINTVKCCVCNKNHASAPVILFKNCQRYIWGEIEILKPDILITQGKRAREALKEVFGIFESEDCSLCRSQWIRLGEKSVLWFPTYHPRNFGVFNRQRKECFEIWAQFIYEAFHSGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N358</accession>
    <name>E8N358_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoJ</name>
        <name evidence="2" type="ordered locus">ANT_08380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559264.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08380"/>
    <dbReference type="EnsemblBacteria" id="BAJ62872">
        <property type="protein sequence ID" value="BAJ62872"/>
        <property type="gene ID" value="ANT_08380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08380"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085957_4_0_0"/>
    <dbReference type="OMA" id="MLVNKRE"/>
    <dbReference type="OrthoDB" id="1683794at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19424" checksum="710AA81E1A8D7DCD" modified="2011-04-05" version="1">MTIVFFVLAFVAVGCAISMLITRNAVYSALFLVLNFATVAILYLILGAPFIALSQITVYAGSVIVLFLFVVMLLGAERLPGAEPLRWQRFIAMGLGLVLAVNLGWSVVQRAGDLGVITAPEKGFGAPVEVGRVLFTQYVLPIQIVAFILLVAVVGAVVLARSEEISRRRELYRKPEAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N372</accession>
    <name>E8N372_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 12">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 14" type="primary">guaB</name>
        <name evidence="14" type="ordered locus">ANT_08520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 12">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 12"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62886">
        <property type="protein sequence ID" value="BAJ62886"/>
        <property type="gene ID" value="ANT_08520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08520"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_0"/>
    <dbReference type="OMA" id="HDYHMTL"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 12" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="156"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="340"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="251"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="300"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ62886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="481" mass="51410" checksum="CFF3D59BD761CDF6" modified="2011-04-05" version="1">MPMKIRSDVALTFDDVLLVPRRSDVRSRKQVDTSSYLTKQIRLKIPIVSANMDTVTETRMAIAMARQGGIGILHRFMTIPQQVEMVERVKRAESMIVDNPITIAASATVQQARELMAEREVGGLVVVSDEGKLLGMVTTRDVLLAVNGDAPVSQVMTPRERLVVAGKEETLESAREKLYQHRIEKLPLVDENDRVVGLITAQDIVKIQEHPNATKDARGRLMVGVAVGARGEDVERAQACVEAGADVVVIDIAHGHSDLVLDMLRTLKKKLSVPIIAGNVATAEGVRDLAEAGADAVKVGVGAGSICITRVVTGFGIPQLTAILECAREGQRLGVPIIADGGVRNSGDLVKALAAGASTVMLGSALAGTDESPGASVVREGRRYKVVRGMASLTANIQRKAIEKGEISEEDWGEVVPEGVEAIVPARGTVVDILHQFVGGLRSGLSYAGAHTIEELWKNAEFVPITQAGYRESGAHDVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H1</accession>
    <name>E8N3H1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62985">
        <property type="protein sequence ID" value="BAJ62985"/>
        <property type="gene ID" value="ANT_09510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09510"/>
    <dbReference type="HOGENOM" id="CLU_2257864_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="103" mass="11808" checksum="CC336DF371FAA0AA" modified="2011-04-05" version="1">MQMDKEYWLELRLEQAREVVRRLERISADSYWAHQSSGVRGSLWRIIERLEKVRLGKAAFRPDDLSRLESLLDEAHAMLVAAGREIPDPEAKNHPSGQATPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P5</accession>
    <name>E8N3P5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">adk</name>
        <name evidence="10" type="ordered locus">ANT_10250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559450.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63059">
        <property type="protein sequence ID" value="BAJ63059"/>
        <property type="gene ID" value="ANT_10250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10250"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_0"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="220" mass="24026" checksum="0182EEF55AE0F311" modified="2011-04-05" version="1">MATYIVLLGPPGAGKGTQATQIVQTFGLAHVSTGDLFRENLRNQTELGQLAASYMNAGKLVPDDVTIAMVRERITRPDCAQGVLFDGFPRTVAQADALSAMLAELSGKVDCVPYISVPAEVLVERLSGRISCPTCGRVYHVTNNPPKQPGVCDADGTPLIQREDDKPETVRKRIEEYLKNTAPLIDYYRERQLLVEIDGTQSIEVVSQQILNAIRKVKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S5</accession>
    <name>E8N3S5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
            <ecNumber evidence="7">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">murE</name>
        <name evidence="12" type="ordered locus">ANT_10550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10550"/>
    <dbReference type="EnsemblBacteria" id="BAJ63089">
        <property type="protein sequence ID" value="BAJ63089"/>
        <property type="gene ID" value="ANT_10550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10550"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_0"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="115"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="346"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="522" mass="57236" checksum="310A61C969EA8376" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X7</accession>
    <name>E8N3X7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BcrAD_BadFG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559531.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63141">
        <property type="protein sequence ID" value="BAJ63141"/>
        <property type="gene ID" value="ANT_11070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11070"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_1_2_0"/>
    <dbReference type="OMA" id="DTMGSMF"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="5"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="335" mass="35571" checksum="7EE0D8E4FAC89F6E" modified="2011-04-05" version="1">MPVYLGIDVGGTKTHALLADEHGNVLGMGCAGPGNHEGVGYDGLTRAMKEALEGALTQSGVKKEDIAGAGFGIAGYDFPSERQPTLESIAALGLSCPVEAVNDVVIGLIAGTSEGWGVVVDAGTGNNVRARTRDGREGWVTGCGGLFGEYGGATDIVYRAVQAISHHWSTRGPTTRLSEAFMQAFDAPDLTALIEGIALEKYPLSAELARLVFEVAYQEDEVAREVIQWTARELGETTKAVIRQVNLQDETFEVVLIGSVFKGGPLFTEPLMQTIQEFAPRAMFHALQAPPVIGAVLLGMEQAGEMAFPATRKRLVKSAFTFLKNSLNAAPFPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N404</accession>
    <name>E8N404_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_11340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559556.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63168">
        <property type="protein sequence ID" value="BAJ63168"/>
        <property type="gene ID" value="ANT_11340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11340"/>
    <dbReference type="HOGENOM" id="CLU_1025440_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="271" mass="30771" checksum="147E5CDD72557DBD" modified="2011-04-05" version="1">MNTSRRFWLWVFGWLCFPILACNLPISVQSEPTPDLFFTTPVPTVTMFSQTRNLPTSTFLPTYTMPPTPTLPPGFDETFDAGLENWKDLYVLTTRAPGGKLSSRIRQSAGALIFDMQDAETYLYRIHRSVMSPNMVVEAEVSVDGQKDNGFMLVCRVDESLSNWYEARVSGTGAFWILRYDRALKEREKKNPYVQLMSGTGPADVFRVGETNSVRFSCLENRISLQFNGRGEVYSVENGDWRQGTFAGFGVFTYEKLPVTVRFERVLASQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N413</accession>
    <name>E8N413_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_11430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63177">
        <property type="protein sequence ID" value="BAJ63177"/>
        <property type="gene ID" value="ANT_11430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11430"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_4_0_0"/>
    <dbReference type="OMA" id="DTYYMFY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225462" evidence="5">
        <location>
            <begin position="27"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="358" mass="39919" checksum="D1BDB9ECBD5E987A" modified="2011-04-05" version="1">MKLTFRLPCILILSLCLVMNACLPFANESQASTFPTSINTVTVSAGETFQNPVLRENFADPFILQRDDTFYLYATNSSGKNIPLAISTDLVHWKIQGDAMPALPKWAKLTGGLVWAPEVMEFNGKFLLYYTARDQTSNKQCVGVAVSDRPEGKFRDINPTPLVCQSDQGGTIDASPFRDEDGKTYLYFKNDGNCCGIPTYIWVQELTEDGLGLVGKPVPLIRNDALWEGNVIEAPTMFKRNGKYYLFYSANDYASHLYAVGYALCTTPMGPCTKAKENPILKSALENKEAMVIGPGHQTILQIGENTWMIYHAWEVVAGSRRGDRRFVWMDLVEWDNEKPVLKGPTTHPQPVPLVSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N437</accession>
    <name>E8N437_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_11670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559589.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63201">
        <property type="protein sequence ID" value="BAJ63201"/>
        <property type="gene ID" value="ANT_11670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11670"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_0"/>
    <dbReference type="OMA" id="PKVKYLN"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="320" mass="35695" checksum="CD745A2EC9AAC594" modified="2011-04-05" version="1">MRILVTGAAGFLGSHLCDRLIKEGHFVIGMDNFITGSPDNLAHLAGNPNFLFIRHDVSNFIFVPGKVDAVLHFASPASPNPNSPYGYTNLPIQTMKAGALGTHNTLGVARAHRAKYLLASTSEIYGDPLEHPQKESYWGHVDPIGVRSVYDEAKRFAEALTMAYHRYHGIDTRIVRIFNTYGPRMRLDDGRVVPNFIQQALRHEPLTIYGDGSQTRSFCYVDDLIEGIYRLLLSDEHNPVNIGNPTETTILEFAQTINQIVGNPAGVVFQPASRLGDDPQRRQPDITRARQILKWEPKISLAEGIQRTIPYFSQKMGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N468</accession>
    <name>E8N468_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559620.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11980"/>
    <dbReference type="EnsemblBacteria" id="BAJ63232">
        <property type="protein sequence ID" value="BAJ63232"/>
        <property type="gene ID" value="ANT_11980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11980"/>
    <dbReference type="HOGENOM" id="CLU_1821394_0_0_0"/>
    <dbReference type="OrthoDB" id="2191301at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="141" mass="15773" checksum="E073CE53EDC932A5" modified="2011-04-05" version="1">MSTVPHSFPPFRSFLWASVLLGLLGWGGLAILVVTTLPTLFPRWMFFYLLMCALSGLALPVAYFLNLRFRTNPPATSGVILREAMWVGIYGCLIAWLQIGRMLTPLLALVLACGFAIVEVLLRIYEISRWQPEQGEDEPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N491</accession>
    <name>E8N491_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559643.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12210"/>
    <dbReference type="EnsemblBacteria" id="BAJ63255">
        <property type="protein sequence ID" value="BAJ63255"/>
        <property type="gene ID" value="ANT_12210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12210"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_1_0"/>
    <dbReference type="OMA" id="TYGAMPF"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="400" mass="44527" checksum="1F0190DE223A05D2" modified="2011-04-05" version="1">MAELNLSIMDRGPDTMTYLKPLLDQFYHQQNIRVNVNLIGWQNGRSELVRYAIYHNSPDVSEVGTTWTSDLIAMNALRPFSPNEIESMTQVGDFLPAAWESTHLAGKTDTVWSIPWLAESILVHYRKDLLAKAGLDPSTAFSTLPQFQKTAEALQAIGIPIPVALPGKNSNTVLLQALASWIWRFGGDFVSTDGKKILLTSPEAYNGMEAFFNLLKTATVEGLQLLDSLDVYGALHQGYAAIGLGALWLRNRTEATRPEIYEQLATARIPGIPFVGGSNLVIWRESRREQAALELVRFLTSPASQIYYGRGAGMLPTRIKTLNLEDYQSDPAAQAMIESLKAGRPFPSVPLWGIVEDRLKMALYQVWMSFMRNPNLNLRETLEQIIGQTAKQLSLTLSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A0</accession>
    <name>E8N4A0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12300"/>
    <dbReference type="EnsemblBacteria" id="BAJ63264">
        <property type="protein sequence ID" value="BAJ63264"/>
        <property type="gene ID" value="ANT_12300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12300"/>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055261_1_4_0"/>
    <dbReference type="OMA" id="TIAWLQS"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="148" mass="17168" checksum="E609BC00F2FF7C41" modified="2011-04-05" version="1">MAPLSSQKRGKGTKIMAVADRSGLPIAISVSSASPHEITLVEPTLDTMFTEELPKRLIGDKAYNSDPLDEKLAENGVELIAPHRSNRKKQKAQDGRKLHRYRRRWKVERLFAWLQNYRRILVRFDRIVENYIGFVHLGCLVILLRHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A4</accession>
    <name>E8N4A4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12340"/>
    <dbReference type="EnsemblBacteria" id="BAJ63268">
        <property type="protein sequence ID" value="BAJ63268"/>
        <property type="gene ID" value="ANT_12340"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12340"/>
    <dbReference type="HOGENOM" id="CLU_3246432_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="42" mass="4200" checksum="7C7F5559856BF9DC" modified="2011-04-05" version="1">MTSGKSNVGVRVIVGVFVIVGVDEGEGVKVIVGVNEGVGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C3</accession>
    <name>E8N4C3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bidirectional hydrogenase U subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hoxU</name>
        <name evidence="9" type="ordered locus">ANT_12530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559675.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12530"/>
    <dbReference type="EnsemblBacteria" id="BAJ63287">
        <property type="protein sequence ID" value="BAJ63287"/>
        <property type="gene ID" value="ANT_12530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12530"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_3_0"/>
    <dbReference type="OMA" id="NHVCAVC"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016214">
        <property type="entry name" value="NAD-red_Hydgase_HoxS_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000309">
        <property type="entry name" value="NAD_red_hyd_HoxU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="240" mass="26800" checksum="2CF4C4E4B7D9CC00" modified="2011-04-05" version="1">MMTPGTAVKTFTMDGKPFSATEEETILDVARENGIDIPTLCHLEGILPTGQCRLCMVEIQGSGRLVPACATKPEEGMDIITDNPRLRNYRKMIVELLFSERNHICAVCVSNGHCELQSVAQRLGVNHVRFAYLHPRFMLDGSHPKYEVDHNRCILCGRCVRVCEEIEGAHTRDLRNRGIRTMVITDFDTPWGESPTCTGCGKCVHVCPTGALAEKGKSVAEMAKRRHFLPYLAMRRRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C5</accession>
    <name>E8N4C5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bidirectional hydrogenase H subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hoxH</name>
        <name evidence="4" type="ordered locus">ANT_12550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559677.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12550"/>
    <dbReference type="EnsemblBacteria" id="BAJ63289">
        <property type="protein sequence ID" value="BAJ63289"/>
        <property type="gene ID" value="ANT_12550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12550"/>
    <dbReference type="eggNOG" id="COG3259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044556_0_0_0"/>
    <dbReference type="OrthoDB" id="1967820at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="475" mass="52994" checksum="AB4A2F1E79AA4693" modified="2011-04-05" version="1">MSERIVIEQVTRIEGHARVSIFLNDDGSVKDAQVHVTQVRGFEKFVQGRPFYEMPSLTARTCGICPVSHLIASAKACDQILSVRIPPTAISLRRILNLGQIIQSHALNFFYLSSPDLLLGMDADPAKRNILGVAQEHPQFARDGIRLRQFGQQVIERLAGKRIHPAWVIPGGVATPLDPSAREQILKEIPEAKSIIQRTLDWYKKNLNAYQEYIRTFANFPSLFLGLVSKEGRLEHYHGYLRVVTARGSILADQLSVENYADYIGESVEPWSYLKSPYYKPLGYPGGMYRVGPLARLNIANECGTPLADQELAEFHCLDKGAVLSSFHYHYARLIEILYAIERIEQLLDDPDILSTNVRAHAEVNNLEGIGVSEAPRGTLIHHYKVDEHGLIQWANLIIASGHNNLAMNRGVLQAARYYVKSSQLTEGMLNRVEAVIRAFDPCLACSTHAVGQMPLAIELVSPDGKVVDTLVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E5</accession>
    <name>E8N4E5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_12750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559697.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63309">
        <property type="protein sequence ID" value="BAJ63309"/>
        <property type="gene ID" value="ANT_12750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12750"/>
    <dbReference type="eggNOG" id="COG4277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033784_1_0_0"/>
    <dbReference type="OMA" id="GYIHLKA"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF9">
        <property type="entry name" value="PTHR21180:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01102">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="60"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="397" mass="45052" checksum="D8BFFD53943060BA" modified="2011-04-05" version="1">MFYNEAVDTLEKFRLLQSEMRLEVADDIPLSSVSSGQSAVESGVSGDCPVDFPISTATLPNGRKIPLLKSLLTSACERNCHYCPFRTGRDFRRVTFKPEELAKVIVELTTKGVIQGAFLSSGIAGGGLRTQDRLLITAEILRKKYQYQGYLHLKIMPGAEYDQVVHAMQLADRVSINLEGPNTRVLQALAPQKIFFEELLEPLRWVEKIRQILPPWRGWKSRWPSSTTQFVVGAVGESDLEILSTTAWLYQKVRLARAYFSGFSPTPDTPFEDRAACSPWREHRLYQASFLLRDYGFDLEDFPFTSGGNLPLDTDPKMAWAQIHLLQSPVEINRAEKRELLRVPGIGPKTAEAILAARRRHRITSEEDLKRLGIPLQRAAAFLLVNGRRLQHQLRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N6</accession>
    <name>E8N4N6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559784.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63400">
        <property type="protein sequence ID" value="BAJ63400"/>
        <property type="gene ID" value="ANT_13720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13720"/>
    <dbReference type="HOGENOM" id="CLU_1192805_0_0_0"/>
    <dbReference type="OrthoDB" id="2145934at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228660" evidence="1">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="232" mass="26059" checksum="3B64A2713B29000C" modified="2011-04-05" version="1">MKKFLWFYLVFLLFFLSPSHPTFLGVPKTGGESSDTQENRFVSDLRTFQKQIDSDKAFAGLFAPDVFAYPVVLQPQNAHAFVSSRPDELTYFALAEKFGSVGLLAHNTLAGKDFFSLKAGDEVGYYQRGVWQWYRVEQILQFQALTPESPTSDFRDLEHPERVLSASALFQEIYAQPGKLILQTCVARGQIDSWGRLFIVAAPISSTETKFDALQIFSANPSSLLEAVPTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4X0</accession>
    <name>E8N4X0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_14560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14560"/>
    <dbReference type="EnsemblBacteria" id="BAJ63484">
        <property type="protein sequence ID" value="BAJ63484"/>
        <property type="gene ID" value="ANT_14560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14560"/>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035904_2_0_0"/>
    <dbReference type="OMA" id="FDWPQVK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="2">
        <location>
            <begin position="91"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="413" mass="48054" checksum="C82A19B8DECE1D61" modified="2011-04-05" version="1">MTNLREKLQSLGYKKDNGSSKSETNVLTDNHGQTRQVNDSTFQDRLYKVIQSYPLPYPHGEVLIEDSAPLGMIGEWAKTPQISALTLSDVVFIDTETSGLVGGTGTFAFMAGIGLYKEKRFEVHQIFLPEPVDEFAFLEEIHRILSPFPVIVTFNGKSFDLPLLQTRFILNRMQTIPEEKNHIDLLHLARRFWRERLESCSLSELEKQILHVQREEQEVPGYLIPEIYFRYLKTKDFSLLNGVFYHNRVDILSMAALFQFMSRVLSQPEIFPLHSMDLASVARLYHDMGYWDMASHLYSQALSEEMPQDILIKTFLRNAEIHKKKGNLPEAIELWKKAAEYGNLEAHLELAKIYEHTLKNLEIALEWANRAFTLCNTLPLPLWKRKEWLREISHRIQRLEQKKRKDSYGTTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B7</accession>
    <name>E8N5B7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ffh</name>
        <name evidence="9" type="ordered locus">ANT_16050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560011.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16050"/>
    <dbReference type="EnsemblBacteria" id="BAJ63631">
        <property type="protein sequence ID" value="BAJ63631"/>
        <property type="gene ID" value="ANT_16050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16050"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_0"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="187"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="440" mass="48492" checksum="51857E75BE6B7222" modified="2011-04-05" version="1">MFETLTQRLEQIFTNLRRRGKLTEQDVDAVMREVRLALLEADVHYSVVKDFVSRVRERAVGAEVSRALNPAQQVIKIVHEELIKTLGEPQWLNLTGPKPRALMLVGLQGSGKTTAAAKLARLLRSQGERVLLVAADPYRPAAVKQLQTLGEKVGVPVYYEEKVAPPLLCAKAYEHAQKGGYSVIIMDTAGRSQLDDALMAELKAITDKVSPADILLVVDSMIGQEALHVAQGFRQAVNLTGLIMTKMDGDSRGGAAISIRSVTGVPIKFLGTGEGIDALEVYDPSRLASRILGMGDVIGLIEKAQQAYDEKTAREQAEKMMSGRFTLEDFANQLRQVKKLGPLAQILEMLPGQLGQAAKMVDPKDAERQLKMTEAIINSMTREERLNPDILNASRRRRIARGSGTDVQDVNRLIKQFREAQKLFKTFQKTGGRGLPNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H1</accession>
    <name>E8N5H1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_16590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560064.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63685">
        <property type="protein sequence ID" value="BAJ63685"/>
        <property type="gene ID" value="ANT_16590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16590"/>
    <dbReference type="eggNOG" id="ENOG502ZXTA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1830958_0_0_0"/>
    <dbReference type="OMA" id="ITRNADW"/>
    <dbReference type="OrthoDB" id="2009272at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="140" mass="15986" checksum="6FEAB2F11AD44E07" modified="2011-04-05" version="1">MGRVINPDSAGRERTRLTKATVLALRALMRQTQPDDTSRDLASFISLALLQISETIDVSVEAWEKRGYWLKADRFRLEWEWAKHSGKQMQDAVLRDDWAEIARISAFVGGKLMKVVVSDKHRLGTPWVGAYQMLLKSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N627</accession>
    <name>E8N627_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_18650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560268.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63891">
        <property type="protein sequence ID" value="BAJ63891"/>
        <property type="gene ID" value="ANT_18650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18650"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="35078" checksum="EE7A58839DF12A6E" modified="2011-04-05" version="1">MMIRATALTKDYGTRRAIENLTFNARKGEILGFLGPNGAGKTTTMRILTGFMPPSSGSVEIGGYDVIENSLEVRRIVGYLPETVPLYSDMTVHEYLEYMGSLRKVPRLEQRINETIEKVELSDRASSYVGALSKGMRQRLGLAQALIHQPEVLILDEPTIGLDPGQVVNFRKLIREIGKDKTVLLSTHILPEAQQICDRVLIINNGHIVAEDTPEQLQARLTGSQRVLVQIRGDSKDVLPIVENIPGVIRAQVRNQDSIEFESLPGKDVRPEVARTLIQRGFDLLQMQNINLSLEEIFLKLTREEPAEITDSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N691</accession>
    <name>E8N691_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560328.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63955">
        <property type="protein sequence ID" value="BAJ63955"/>
        <property type="gene ID" value="ANT_19290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19290"/>
    <dbReference type="eggNOG" id="ENOG5033NIR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096866_0_0_0"/>
    <dbReference type="OMA" id="MAWILRV"/>
    <dbReference type="OrthoDB" id="2080138at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="28025" checksum="38EB7F5DCEC54E41" modified="2011-04-05" version="1">MDGFSFWGGLVWLFGLTVPLLYLQRQLHREIQLTFFLITRHPTVTMGIFALLFLPGVLVHEVSHLLMAWILRVPTGRLSLLPRFLPNGKVQLGAVETAPADIFRDALIGAAPLITGGALVAYLGASRLGLLPLFEAIRSHNNDLFWSLLKHLPELPDFWLWFYLTFTISTTMFPSEADRRTWLPVLGIGASLGMLAWLSGAGGWLSGTFAPLLAQVIQVGISISAISLVLHLALWFPFRLLRAVFQGKARITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A1</accession>
    <name>E8N6A1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme exporter protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ccmC</name>
        <name evidence="9" type="ordered locus">ANT_19390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560338.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63965">
        <property type="protein sequence ID" value="BAJ63965"/>
        <property type="gene ID" value="ANT_19390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19390"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066538_1_0_0"/>
    <dbReference type="OMA" id="FHVPMWF"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="8">
        <location>
            <begin position="10"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="232" mass="26249" checksum="2F651E0E7F239FCD" modified="2011-04-05" version="1">MKTQPRLLVFTDVLALLAMLIATGMVFLYAPIERVMGPVQKVFYFHVATGWVGMLGFLVAVIAGIAYLITRKSHWDLVGVGAIEIGLVFMLINIITGSIWARPIWNTWWTWDPRLTTATIMELVYAAYLLLRQGIDDPEKRARFGAVYAIVGFISVPLTFFSIRIYRTIHPVVIGGADPTVTGSFSMTPPMAQTFMVSLIAFSILFISLLWHRIRLGELAQRVEQLRLKWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A5</accession>
    <name>E8N6A5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_19430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560342.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63969">
        <property type="protein sequence ID" value="BAJ63969"/>
        <property type="gene ID" value="ANT_19430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19430"/>
    <dbReference type="eggNOG" id="ENOG5033BA3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1559774_0_0_0"/>
    <dbReference type="OMA" id="VEHQYSA"/>
    <dbReference type="OrthoDB" id="1865456at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="3">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="19032" checksum="024C0DC1081AC0E1" modified="2011-04-05" version="1">MDAGSLLIILAVTVIVGAFIARPFFVVEKKSRVPLVNNPVEHQYSALLAEKERLAQALQELDFDNALGKIPQEDYPLMRAALLKQAAEVLQALEKLEQEIGFHGVSVEKEVPGAVQVEQSSDDIEELIRLRRKQRQERSSGFCSKCGNPVQKSDRFCPRCGNALVMLGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C8</accession>
    <name>E8N6C8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560365.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63992">
        <property type="protein sequence ID" value="BAJ63992"/>
        <property type="gene ID" value="ANT_19660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19660"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_2_0"/>
    <dbReference type="OMA" id="ATEGREY"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="33"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="311" mass="34742" checksum="F67C47C770206825" modified="2011-04-05" version="1">MIANFAQRILDNVQKIFVGKEEAIRLLLVAVLCEGHVLIEDVPGTGKTTLARALATTLGCTFRRIQFTPDLLPSDITGISWFNQKTQEFEYRPGPIMTQILLADEINRATPRTQSALLEAMQERQVTADGVTRPLERPFLVLATQNPVELEGTFPLPEAQVDRFFLRVTLGYPNSSEENAILERFGAHDPFKDLPPVTHPQEIFEMIEARQRIHVESSIRDYMVKIARATREDADILLGASPRATLALYQASQALAGIRGRNYVIPDDVKCIIAPVLAHRLVISPQAQLRGRNAQDLIHEIVARIPVPVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6E6</accession>
    <name>E8N6E6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">upp</name>
        <name evidence="12" type="ordered locus">ANT_19840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64010">
        <property type="protein sequence ID" value="BAJ64010"/>
        <property type="gene ID" value="ANT_19840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19840"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_2_0"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="209" mass="22964" checksum="B30BAED778826F3F" modified="2011-04-05" version="1">MEMTVIISNHPLVQHKLSILRNVNTEPKKFRQLVRELAALLTYEATSDLATTPVDVQTPLAVAHCRELKEKIGLVPILRAGLGMVEGVWELMPSSEVWHIGVYRDEKTLKPVQYYNKLPVEPRVQVCLILDPMLATGGSAVATADILKTWGVKKIKFVGLIGAPEGIALMEKHHPDVPIHLAAIDDHLNEKGYIVPGLGDAGDRQFGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF4</accession>
    <name>E8MXF4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_20090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560406.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20090"/>
    <dbReference type="EnsemblBacteria" id="BAJ64035">
        <property type="protein sequence ID" value="BAJ64035"/>
        <property type="gene ID" value="ANT_20090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20090"/>
    <dbReference type="HOGENOM" id="CLU_312088_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="940" mass="104942" checksum="09225031EA084977" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF7</accession>
    <name>E8MXF7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative transposase for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03190</name>
        <name evidence="3" type="ordered locus">ANT_05640</name>
        <name evidence="4" type="ordered locus">ANT_07940</name>
        <name evidence="5" type="ordered locus">ANT_09160</name>
        <name evidence="6" type="ordered locus">ANT_10360</name>
        <name evidence="7" type="ordered locus">ANT_11160</name>
        <name evidence="8" type="ordered locus">ANT_11230</name>
        <name evidence="9" type="ordered locus">ANT_13090</name>
        <name evidence="10" type="ordered locus">ANT_13620</name>
        <name evidence="11" type="ordered locus">ANT_13630</name>
        <name evidence="12" type="ordered locus">ANT_13920</name>
        <name evidence="13" type="ordered locus">ANT_13930</name>
        <name evidence="14" type="ordered locus">ANT_15800</name>
        <name evidence="15" type="ordered locus">ANT_17170</name>
        <name evidence="16" type="ordered locus">ANT_18130</name>
        <name evidence="17" type="ordered locus">ANT_19210</name>
        <name evidence="18" type="ordered locus">ANT_20120</name>
        <name evidence="19" type="ordered locus">ANT_22280</name>
        <name evidence="20" type="ordered locus">ANT_26070</name>
        <name evidence="21" type="ordered locus">ANT_26600</name>
        <name evidence="22" type="ordered locus">ANT_27320</name>
        <name evidence="23" type="ordered locus">ANT_28100</name>
        <name evidence="24" type="ordered locus">ANT_28340</name>
        <name evidence="25" type="ordered locus">ANT_29990</name>
    </gene>
    <organism evidence="18 26">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="18 26" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="18">UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03190"/>
    <dbReference type="EnsemblBacteria" id="BAJ62353">
        <property type="protein sequence ID" value="BAJ62353"/>
        <property type="gene ID" value="ANT_03190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62598">
        <property type="protein sequence ID" value="BAJ62598"/>
        <property type="gene ID" value="ANT_05640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62828">
        <property type="protein sequence ID" value="BAJ62828"/>
        <property type="gene ID" value="ANT_07940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62950">
        <property type="protein sequence ID" value="BAJ62950"/>
        <property type="gene ID" value="ANT_09160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63070">
        <property type="protein sequence ID" value="BAJ63070"/>
        <property type="gene ID" value="ANT_10360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63150">
        <property type="protein sequence ID" value="BAJ63150"/>
        <property type="gene ID" value="ANT_11160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63157">
        <property type="protein sequence ID" value="BAJ63157"/>
        <property type="gene ID" value="ANT_11230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63342">
        <property type="protein sequence ID" value="BAJ63342"/>
        <property type="gene ID" value="ANT_13090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63391">
        <property type="protein sequence ID" value="BAJ63391"/>
        <property type="gene ID" value="ANT_13620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63392">
        <property type="protein sequence ID" value="BAJ63392"/>
        <property type="gene ID" value="ANT_13630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63420">
        <property type="protein sequence ID" value="BAJ63420"/>
        <property type="gene ID" value="ANT_13920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63421">
        <property type="protein sequence ID" value="BAJ63421"/>
        <property type="gene ID" value="ANT_13930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63607">
        <property type="protein sequence ID" value="BAJ63607"/>
        <property type="gene ID" value="ANT_15800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63743">
        <property type="protein sequence ID" value="BAJ63743"/>
        <property type="gene ID" value="ANT_17170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63839">
        <property type="protein sequence ID" value="BAJ63839"/>
        <property type="gene ID" value="ANT_18130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63947">
        <property type="protein sequence ID" value="BAJ63947"/>
        <property type="gene ID" value="ANT_19210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64038">
        <property type="protein sequence ID" value="BAJ64038"/>
        <property type="gene ID" value="ANT_20120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64254">
        <property type="protein sequence ID" value="BAJ64254"/>
        <property type="gene ID" value="ANT_22280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64633">
        <property type="protein sequence ID" value="BAJ64633"/>
        <property type="gene ID" value="ANT_26070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64686">
        <property type="protein sequence ID" value="BAJ64686"/>
        <property type="gene ID" value="ANT_26600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64758">
        <property type="protein sequence ID" value="BAJ64758"/>
        <property type="gene ID" value="ANT_27320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64836">
        <property type="protein sequence ID" value="BAJ64836"/>
        <property type="gene ID" value="ANT_28100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64860">
        <property type="protein sequence ID" value="BAJ64860"/>
        <property type="gene ID" value="ANT_28340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ65025">
        <property type="protein sequence ID" value="BAJ65025"/>
        <property type="gene ID" value="ANT_29990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03190"/>
    <dbReference type="KEGG" id="atm:ANT_05640"/>
    <dbReference type="KEGG" id="atm:ANT_07940"/>
    <dbReference type="KEGG" id="atm:ANT_09160"/>
    <dbReference type="KEGG" id="atm:ANT_10360"/>
    <dbReference type="KEGG" id="atm:ANT_11160"/>
    <dbReference type="KEGG" id="atm:ANT_11230"/>
    <dbReference type="KEGG" id="atm:ANT_13090"/>
    <dbReference type="KEGG" id="atm:ANT_13620"/>
    <dbReference type="KEGG" id="atm:ANT_13630"/>
    <dbReference type="KEGG" id="atm:ANT_13920"/>
    <dbReference type="KEGG" id="atm:ANT_13930"/>
    <dbReference type="KEGG" id="atm:ANT_15800"/>
    <dbReference type="KEGG" id="atm:ANT_17170"/>
    <dbReference type="KEGG" id="atm:ANT_18130"/>
    <dbReference type="KEGG" id="atm:ANT_19210"/>
    <dbReference type="KEGG" id="atm:ANT_20120"/>
    <dbReference type="KEGG" id="atm:ANT_22280"/>
    <dbReference type="KEGG" id="atm:ANT_26070"/>
    <dbReference type="KEGG" id="atm:ANT_26600"/>
    <dbReference type="KEGG" id="atm:ANT_27320"/>
    <dbReference type="KEGG" id="atm:ANT_28100"/>
    <dbReference type="KEGG" id="atm:ANT_28340"/>
    <dbReference type="KEGG" id="atm:ANT_29990"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056491_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="109"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ63607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ63743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAJ63839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAJ63947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAJ64038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAJ64254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="BAJ64633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="BAJ64686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="BAJ64758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="BAJ64836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="BAJ64860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="BAJ65025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="279" mass="31880" checksum="98AB1C1E26D37B89" modified="2011-04-05" version="1">MTTRESRYVRVARIAYRLAKQALPMYSHAKSPHHFTLPQLGACVLLMFYLNLSYRDMEEWLLASDAVGKELELPRVPDHTTLQRTYAKIRKADWMRMNETLLEEIGRPEEEGVAADSTGFSPGPASSYYQSRSGKAYRHWAKGVYAVGIVSQFILAMQSGWGPGSDAPYLGYLRRKARRFAKRRAWVLLADSGFDGRTVRPQDLIPPVRRGGNLLAPERRARSELVSAARLDGLYGQRWKTETVNSVIKRKFGQAIRSRKRSLQNREPIIKGLVYNIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXI3</accession>
    <name>E8MXI3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">ANT_20380</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the etk/wzc family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560434.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20380"/>
    <dbReference type="EnsemblBacteria" id="BAJ64064">
        <property type="protein sequence ID" value="BAJ64064"/>
        <property type="gene ID" value="ANT_20380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20380"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_4_2_0"/>
    <dbReference type="OMA" id="IQKNIAM"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="17">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="18">
        <location>
            <begin position="336"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="BAJ64064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="513" mass="57434" checksum="D18BA2C5B93957C9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP5</accession>
    <name>E8MXP5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_21000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21000"/>
    <dbReference type="EnsemblBacteria" id="BAJ64126">
        <property type="protein sequence ID" value="BAJ64126"/>
        <property type="gene ID" value="ANT_21000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21000"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1840457_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="14838" checksum="0C090F5527FC082F" modified="2011-04-05" version="1">MTHVITSLCLRDGGCATVCPVECIVPGQPVDEWPWYYIDPDTCIDCGACVPECPWEAIFPEDEVPSQFKAKEGQRLSMPVGTPGFDQVYDGVNHDGDPVHLEATKVLHAGEVVDLTPAIEINREFFTKGPGYSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ6</accession>
    <name>E8MXZ6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_22010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22010"/>
    <dbReference type="EnsemblBacteria" id="BAJ64227">
        <property type="protein sequence ID" value="BAJ64227"/>
        <property type="gene ID" value="ANT_22010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22010"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_6_0"/>
    <dbReference type="OMA" id="FRGRISY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="146" mass="16585" checksum="4C22B328F56AD414" modified="2011-04-05" version="1">MRKRLGTMVGDVVRSVFKKPATQLYPFERKPAPVAFRGKLVWEPEKCAGCMLCVKDCPANAIELIVLDKVNKRFVMRYHADRCIYCAQCVVSCRFKCLDLSDEEWELASTGKEPFTVYYGKEEDIAFLLEKMARDNAGEGPSCGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY39</accession>
    <name>E8MY39_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative peptidylprolyl isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_22440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22440"/>
    <dbReference type="EnsemblBacteria" id="BAJ64270">
        <property type="protein sequence ID" value="BAJ64270"/>
        <property type="gene ID" value="ANT_22440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22440"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_589159_0_0_0"/>
    <dbReference type="OMA" id="WHIVQLV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="4">
        <location>
            <begin position="290"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="438" mass="48758" checksum="B7A9C4BDF90269A4" modified="2011-04-05" version="1">MAKQPEKKVITNKKHLARIEREQLQRRYLLLGTAIVLIAVIGLIVYGILDQSVLKQNRAVAQVGNEKITVKEFQTEAKFWRYLQVQQYNNLASNPLLVQFYGSYLQELETSLADPQTIGKQVLDAMIEDALVAQEAAKRGITVSEEEIDKEMQEAFGFYINGTPTPTLTATPFATATLTTQQLTWLPPTDTPEPTATPEPATPTPEVTPTPQPTATPTPEGPTPTATASPTPLPTATPYTLEGYKQTYSDFLAKVQVYGYDEAHLRDYIKRLILKRKLADALSADLPREEEKVWARHILVETEETAKEVLDRLNKGEDWVKLAAEYSKDTSNANKGGDLGWFGKGTMVKEFEDAVYALKVGEISQPVQTTFGYHIIQLLGREVRPLTDSEFNQKKQAAYDEWLTQAKSADTVKTFDLWMEVAPSVPAITPVALPSTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY46</accession>
    <name>E8MY46_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_22510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560645.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22510"/>
    <dbReference type="EnsemblBacteria" id="BAJ64277">
        <property type="protein sequence ID" value="BAJ64277"/>
        <property type="gene ID" value="ANT_22510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22510"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_0"/>
    <dbReference type="OMA" id="VYLCCKA"/>
    <dbReference type="OrthoDB" id="1209997at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="263" mass="28247" checksum="B1ED0595AB825692" modified="2011-04-05" version="1">MDLGLRGKIAVVTGASRGLGFATARLLAQEGAQVVINSRNSERLNRAAEQISRESGSEVLAIAGDVTNAEFPSALVQRTVERFGGLDLLVTNTGGPKPGAFEDLNEEDWQRAVDLCLMAHVRLIRAALPILKRSSSPAILTITSISVKQPIPNLILSNAVRAATVGLTKSLALELGQYNIRVNSILPAWVETERIAELLEARAKANQTRIEEEMAKQALESPFGRIAQPEEFARAAVFLLSPAASYLTGVMLPVDGGMYKGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY48</accession>
    <name>E8MY48_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2344 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64279">
        <property type="protein sequence ID" value="BAJ64279"/>
        <property type="gene ID" value="ANT_22530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22530"/>
    <dbReference type="eggNOG" id="COG5011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083579_0_1_0"/>
    <dbReference type="OMA" id="QPCAILR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="24896" checksum="DB2F8073DA6A8B85" modified="2011-04-05" version="1">MSALTRYRLWYARGAELRYVSHLDMMLVWERTFRRARLPLAFSQGFNPRPRFHLASALPLGFTSLCEVADVWLVEPLPPKDVQIRVQRAAPPGLSLQRVEIIPLQHPALQTLVLSAEYLVKFREGCPADIAERIENLLNQKEIIRVRREKSYDLRPLIEALHLVTLPESDLPALAMRLSAKESATARPEEVLLALGIDPITARMERTRLIFQEPVSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY61</accession>
    <name>E8MY61_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_22660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560660.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22660"/>
    <dbReference type="EnsemblBacteria" id="BAJ64292">
        <property type="protein sequence ID" value="BAJ64292"/>
        <property type="gene ID" value="ANT_22660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22660"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="KARKYEV"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="226" mass="25629" checksum="6B6DD4649683A454" modified="2011-04-05" version="1">MTSELILLVDDEPSIVSLCRMYLEREGFRVQSAGDGVTALEMLKKSPPDLMILDVMLPELDGFEVCKQLRAQNDPLPILMLTARDEDYDKILGLELGADDYMTKPFNPRELVARVKAILRRTRHQTHEDQNVIRIGNIVVDPARYEVRNGDYLIPLRAQEFEVLCVLARNAGRVLSREQLLEKAWGFDFYGQTRTVDVHIAQLRRKLADSGVTIETVTGVGYKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY79</accession>
    <name>E8MY79_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatidyltransferase</fullName>
            <ecNumber evidence="3">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560677.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64310">
        <property type="protein sequence ID" value="BAJ64310"/>
        <property type="gene ID" value="ANT_22840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22840"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_722884_0_0_0"/>
    <dbReference type="OMA" id="ANRITMW"/>
    <dbReference type="OrthoDB" id="1746404at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="382" mass="42340" checksum="816B532629857813" modified="2011-04-05" version="1">MIFQGRSILENVRSQGLDLIVLGVTYLGLWGAGIWMLSSLSTGEEWIAWAVSSLAFLGYAFGYLVYHLELNVPPGGDTRYPDLGWANRITMWRAGLLGGLFGLIFLISLQETVRWLAGVLYSLVALLDFVDGWVARRTHRSSRLGETLDMHWDSLGVLIASVLLVRMGQVSPLFVLVGLARFLYVAVIQWRERRGLPLAPLPSNPYRRFMAGIQMGLIAVLLFPVFSPPATTIAAWLWMIPFLTAFLRDGLYVSTAMDEQTDPLLRWGVLASLTRVGPWLFRLLTLISGIGLLFAFPDTPYLFWARTTLAGLGLMVLLGLMGRVTGIAWMMIAGFVLSFSSNHPVAWGALVGGFGLLMLGTGRLSVWSPEEWLIYHRAGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYG1</accession>
    <name>E8MYG1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_00720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00720"/>
    <dbReference type="EnsemblBacteria" id="BAJ62106">
        <property type="protein sequence ID" value="BAJ62106"/>
        <property type="gene ID" value="ANT_00720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00720"/>
    <dbReference type="eggNOG" id="COG0733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006855_3_4_0"/>
    <dbReference type="OMA" id="IFPEWAN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="479" mass="51089" checksum="620F8D3AFC6FE0B2" modified="2011-04-05" version="1">MPGSFFTGTTFLLTGGLFIMANESVHNQAPAKRSGFATALGALIATLGSAIGLGNIWKFPYLTGENGGAAFLVLYLLATFLVGLPVMISEILLGRAGRANVITTMRKLSPSPRQPWWLIGAAGALSAFLIMAFYTEVAGWVFAYVVRSLTSNILSTDPQVTLQTFNALVSDPFQSLLWQWVVLILVGGIITFGVAKGIEATTKRLIPLLFILLLIVDVRALTLPGAGAGLAFLFKPDFSKISTTAALIALGLAFFKLSIGMGAMITYGSYWKDDQNIPSTTLRVVLSDLAVSLLAGIAIFPVVFTYGFEPAAGTKLLFITLPAVFAQMPLGNVFIFLFFLLTSFAATGAMVSLVEVLVAFANEQFHLSRKAATWITVGLLALVGSTAALSNSTLAGFTPFGKTLFDLYDFVTSNVLLPVGGLFIAIFVGWVLKPEQVIAQLTNGGTLSNHGVVRVFLFVVRYISPLLVLVVLLDSLGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP5</accession>
    <name>E8MYP5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560747.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64381">
        <property type="protein sequence ID" value="BAJ64381"/>
        <property type="gene ID" value="ANT_23550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23550"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773163_0_0_0"/>
    <dbReference type="OMA" id="NQTTQMH"/>
    <dbReference type="OrthoDB" id="1049053at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="38731" checksum="D5D8EF2EA8E09A1C" modified="2011-04-05" version="1">MKPNVLLICGSLNQTTIMHQIGRQLEECHVYYTPFYADGFLGLLSKLGVTNFTILGGRHRRDTENYLKTHQLPVDFGGKSRHYDLVITGTDLIIQRNLRGKRILLVQEGMLEPEGWRYHLTRALRLPRFFANTAATGLSDAYHRFCVASNGYREVFIRKGVNPAKIVVTGIPNFDNAVSYLKNDFPLRGYVLVATSATRETMRYHNRLNFLLKVKSHTNGKPVIFKLHPNENIPTATREIRQFFPDAPIYVEGNVHHMIANCDMLIAQNTSAIFTAVALGKPVISDLDTETLRKLLPLQNGGKSAERIAEVARQLLATPLHELEKQSVRPSLSPQWKLPPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS0</accession>
    <name>E8MYS0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative site-specific recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_23800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560772.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23800"/>
    <dbReference type="EnsemblBacteria" id="BAJ64406">
        <property type="protein sequence ID" value="BAJ64406"/>
        <property type="gene ID" value="ANT_23800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23800"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_0"/>
    <dbReference type="OMA" id="ERMVYFD"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="109"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="288" mass="33010" checksum="CE8D892B4ED282C4" modified="2011-04-05" version="1">MITNKTPTVKELVDVFLESQKGFISDSTLRWYVFYLRPLVAHLGDRETNSITTSDLINLFHLMRTDDREPYTLFNFIRGWKRLFRWAVDEGYIAMNPAKKLRRPPLPQKSPAGIQAEDLSKMLDAASKTGTPERDLALVLFVADTGVRLGGVAGLTVDRLDINKRRAIVLEKGRGGQKERVVFFSSRTAIALENWLEKRGETEDQRVFLLKPNGIYQLFKRLARKSEITGKWNPHSFRHAYARKLLAEGVSIGIVSHLMGHSNVQVTIDFYGRFSHDELQEIYDKIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYW6</accession>
    <name>E8MYW6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560807.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64452">
        <property type="protein sequence ID" value="BAJ64452"/>
        <property type="gene ID" value="ANT_24260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24260"/>
    <dbReference type="HOGENOM" id="CLU_2803069_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="67" mass="7784" checksum="7ADA0D0C1C0B1FFF" modified="2011-04-05" version="1">MENWDELLELMRHFVKEEPETAAQVLARLATKFEVTLVVHRQESAPERVERWVVTVSEVVGPEAETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ09</accession>
    <name>E8MZ09_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">thrS</name>
        <name evidence="11" type="ordered locus">ANT_01180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62152">
        <property type="protein sequence ID" value="BAJ62152"/>
        <property type="gene ID" value="ANT_01180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01180"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_0"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="252"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="623" mass="72567" checksum="3286CBA3B6E4520D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ39</accession>
    <name>E8MZ39_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558580.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62182">
        <property type="protein sequence ID" value="BAJ62182"/>
        <property type="gene ID" value="ANT_01480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01480"/>
    <dbReference type="eggNOG" id="COG5184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1292224_0_0_0"/>
    <dbReference type="OrthoDB" id="308036at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="213" mass="22243" checksum="CB40F002238BB284" modified="2011-04-05" version="1">MPQPPPPESQRPARESLPAEQRHRESEFPGSFPDFQSQSFPFSLLTLQPLSGIIQITAGGSHTCALTAASEVYCWGSNRSGEAGIGGYSDLAAPVIPVPGLSGISAIAAGKAHTCALTGAGTVYCWGYNYFGQLGDGTTTSSPTPVQVSGLSNATAIAAGEDHTCALVIDGTVRCWGMNWYGQLGDGTLGYYSLPIQVMQSLPVKTYLPAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ72</accession>
    <name>E8MZ72_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_01810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558613.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01810"/>
    <dbReference type="EnsemblBacteria" id="BAJ62215">
        <property type="protein sequence ID" value="BAJ62215"/>
        <property type="gene ID" value="ANT_01810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01810"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_5_0_0"/>
    <dbReference type="OMA" id="NVRWGIM"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="329" mass="36314" checksum="E1E286ABA378D6ED" modified="2011-04-05" version="1">MAQKPLNWGILSTAHINRALIPVLQSSKRTRLLAVASRSLESAQAYAREWSIPRAYGRYEDLLADPDIDVIYNPLPNHLHADWTIKAVQAGKHVLCEKPLALTLSEVDAMREAAQAHGKIIAEAFMYRHHPQTLKVKEIVDSGILGAVKMVRGAFTFTLDRPGNYRLEPSMGGGSLWDVGCYPLSYARFVLGAEPLEVFGWQTLNPAGCEMSFVAQVRFPGEAFLQFESSFERPPRAFMEFVGSEGRLEVPDPFKPGLSTRLLLTRSGRTETIKVKGKELYLGEVEDLCDAVQMGKPPRISLEDSRGNIAALLALIESAQRGVPVAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE3</accession>
    <name>E8MZE3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560846.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24650"/>
    <dbReference type="EnsemblBacteria" id="BAJ64491">
        <property type="protein sequence ID" value="BAJ64491"/>
        <property type="gene ID" value="ANT_24650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24650"/>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035301_5_3_0"/>
    <dbReference type="OMA" id="GVAPHFQ"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="465" mass="54523" checksum="52E4A284735D91FC" modified="2011-04-05" version="1">MRLPSILYPVEQAFRYLYGALPFSWRAGAQYRRLRRFLSEAQWWDAERIREWQTERLGWMIRYAYENVPGYRHLYEKAGITPADFGTLEDLPAFPLLEKSFVQTDIRAFTSRSVSPRNLTYLTTGGSTGVPVGFYHTRVNRWMEDAFMHAGWEWGGWIPDQKTLTLRGWFQGTPKRFFWYNPLRRELHLSTYYLTVETYPQYFQIAKQFAPLFIQAYPSAMTFFSRLILERGDAGVLQPRVIFLASETIYPWQRELIARAFPTARIFAHYGHTEQAGLGHWCEYIDQYHFWPFYGYLELLDSQGNPVPLGQVGEIVVTSFWNYGTPWIRYRTGDLGILAGNFCSACGRNFPILSNVQGRIQEFLISQYGRLVSFTALNVHNDLFDHVWQFQFYQDTPGKVTLKLLPRSEFSKNDLNRIQQEMSSKLGEDFSLETVCVEQIPLTPRGKFKVIEQKCSLDWIKETIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF8</accession>
    <name>E8MZF8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_24800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560861.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24800"/>
    <dbReference type="EnsemblBacteria" id="BAJ64506">
        <property type="protein sequence ID" value="BAJ64506"/>
        <property type="gene ID" value="ANT_24800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24800"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077373_0_0_0"/>
    <dbReference type="OMA" id="GLGIDCR"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="20140" checksum="9F083A04D5A0298D" modified="2011-04-05" version="1">MSKLIPWYLQPWFRITLGIVVLILLGGAVGGIYLTQQSPPQPIQFPHNFHVGAGIPCLYCHPGAQWGESAGLPSSSLCWGCHQQVAKTKTSPELQKLAQYVERGEEIPWVPVFIQPDFVHFNHRAHVAAGVACETCHGDMKKMTVAQPIPRQNMGWCLNCHSKQPKEKWARLSDCSLCHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI0</accession>
    <name>E8MZI0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560883.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25020"/>
    <dbReference type="EnsemblBacteria" id="BAJ64528">
        <property type="protein sequence ID" value="BAJ64528"/>
        <property type="gene ID" value="ANT_25020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25020"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OMA" id="PPYSLFW"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="36001" checksum="E3184DFEDF87C072" modified="2011-04-05" version="1">MHYRRMGRTGLKLSEISLGAWVTFGSQIDEKTATELIHAAYDQGINFFDNADVYAGGEAEVLMGRAIRGLPREALVLSSKVFWPTMPGPNGRGLSRKHVMESIHASLKRMQVEYFDLYFCHRYDPDTPVEEVVWVMNDLIRQGKILYWGTSEWEPHQIMEAIGIARSLNLIGPSMEQPQYNMFHRKRVENFLAPVCRDYGIGLTTFSPLYFGILSGKYNEGIPAGSRASMESMGWLRDLITPERIAIVRQLTELANELDATTAQLAIAWILRRKEVSAVITGASSLEQMDENLGAAEIAEKLDDDILERIENILGNFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ2</accession>
    <name>E8MZJ2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpmE</name>
        <name evidence="9" type="ordered locus">ANT_25140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25140"/>
    <dbReference type="EnsemblBacteria" id="BAJ64540">
        <property type="protein sequence ID" value="BAJ64540"/>
        <property type="gene ID" value="ANT_25140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25140"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1665795_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA_pol_A_CTD" evidence="8">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="158" mass="17426" checksum="FE2CB3986A32A2EC" modified="2011-04-05" version="1">MKKDIHPTYYPDAQVICACGNTWTTGSTKKVIRTEICSKCHPFYTGEQTRIVDTEGQVDRFYRKLQARQSFAEQKKAREEARTSLERPIASLNLGTRPTEALAKAGITTVGQVIALLEQGEAALLNVEGFGRKALIDLKKTLRGLGYQLPAAADEIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM4</accession>
    <name>E8MZM4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GGDEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560927.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64572">
        <property type="protein sequence ID" value="BAJ64572"/>
        <property type="gene ID" value="ANT_25460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25460"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037495_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="334"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="457" mass="52091" checksum="06D3BD290A6B533B" modified="2011-04-05" version="1">MGLWSERRSRLKGWAEAGEILGVCLLALLLFILGENSFTLFGWAIFPLAMAITREQQLTLLDEDGIANQMDIAVVLVNGNVTVVDINEAGASWVGKARVALKNQPVGEVFGVELEQALRRVSASSVVNMDLYLDTLQPARYVHMWVSRAGWKPGFPGVRLVTLQDITRFMEEKQKLQCNLSLLEATLSDHHNGMMITDPMGRVIYRSNSLIQTFGIPEQTFDTGLIGWRGKMARLMRQPDRFLHFLDRTIQETSGESLEVYETTTGRWMECRSRVLQLPGMYGLYRVWLFHDFTEQMKREQELQRFSMQDGLTGAYNRAYFDSELRRLQLGRRFPVAMVMVDVDGLKAINDQKGHTAGDYLLRQTVELLHHACRADDVVARLGGDEFAILLAPADEYAAEQVTERIRSLQNLYNIRQPDLSLSLSCGWAVATTPQEVDTLFNRSDRMMYLEKRRKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP1</accession>
    <name>E8MZP1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_25630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560944.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64589">
        <property type="protein sequence ID" value="BAJ64589"/>
        <property type="gene ID" value="ANT_25630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25630"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_370756_0_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="302"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="9">
        <location>
            <begin position="618"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="346"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="750" mass="85319" checksum="B733AB65EDEC95BB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR6</accession>
    <name>E8MZR6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560969.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25880"/>
    <dbReference type="EnsemblBacteria" id="BAJ64614">
        <property type="protein sequence ID" value="BAJ64614"/>
        <property type="gene ID" value="ANT_25880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25880"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067083_0_0_0"/>
    <dbReference type="OMA" id="DKIIMDP"/>
    <dbReference type="OrthoDB" id="1729109at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002825">
        <property type="entry name" value="Pept_S49_ser-pept_pro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01972">
        <property type="entry name" value="SDH_sah"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="280" mass="31566" checksum="DC9BB29460AB7ECF" modified="2011-04-05" version="1">MDLLNLFWIFLIVSSLAPMVRQQIIASTRLNLLRRLEEKRGSRVIGLIHRQESMSLLGFPIGRYIDIDDSEQVLRAIKLTDPKVPIDIILHTPGGLVLAAEQIANALSRHPAPVTVFVPHYAMSGGTLIALAANQIVMDENAVLGPVDPQLGQYPAASILKVLEQKDINRVDDQTLILADVARKAMVQVKETVRRIACCHYSQEVAERLADELPSGRWTHDYPITVEEARELGLNISTDMPQEVYQLMNLYPQTMQRRPSVEYVPMPYPWRPSSEKGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT8</accession>
    <name>E8MZT8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-glucose/GDP-mannose dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_02390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62273">
        <property type="protein sequence ID" value="BAJ62273"/>
        <property type="gene ID" value="ANT_02390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02390"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_0"/>
    <dbReference type="OMA" id="MEDFTGM"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="311"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="429" mass="46732" checksum="F723E6246BD1F22D" modified="2011-04-05" version="1">MHMRFQHICVLGLGYIGLPTASTFATHGLRVTGVDVNPAVLNSLQNGETHIYEPGLRTLVQAAVKSGNLAVSPQPVEADAYIIAVPTPFKEGKKADLSFVIAAAEAIVPVLRRGALVVLESTSPPRTTEDVVRPILERSGLKAGQDFYLAYSPERVLPGQILRELIENTRVIGGIDSASAEAGRDLYGVFVRGEIILTDATTAEMVKLMENTYRDVNIAIANEFARLAERFGINVWEAIALANRHPRVRILNPGPGVGGHCISVDPWFLVEAAPDLATLIRTAREVNDSQPHFVVERVRQAAGLLEGLRVAALGLAYKADVDDLRESPAIEVCHLLSQAGAQVRAYEPFKPDAVIEGVETVPTLGEILDEADVLLLLVGHTVLRNLDPVEVAQLTAARIVVDCVNGWEPERWRFNGFHYYRLGDRKEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV0</accession>
    <name>E8MZV0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_02510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558682.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02510"/>
    <dbReference type="EnsemblBacteria" id="BAJ62285">
        <property type="protein sequence ID" value="BAJ62285"/>
        <property type="gene ID" value="ANT_02510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02510"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="OMA" id="IAMVICQ"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="261" mass="28429" checksum="7F7B12AC2A4971C7" modified="2011-04-05" version="1">MDTSMIQVQNLSVELGNQPILREVTFSVQRGEILGILGPNGAGKTTLIRALSGILPPAAGQVQVLGRAVHRLTESQRARLIAVVPQARHLPPAFTGREVVQLGRTPYLNWLGNLSAHDHACVQRALERASALELADRLVGELSGGEQQRLLLARALAQETPILLMDEPTTHLDLHYQISLLETVRHLVDEEGMTVVMALHDLNLIGRYADRLGLLVEGRLIALGTPEEILTPDLLSPVYRVPLQRLSSGDGGRPIILPTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>E8N013</accession>
    <name>E8N013_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03140"/>
    <dbReference type="EnsemblBacteria" id="BAJ62348">
        <property type="protein sequence ID" value="BAJ62348"/>
        <property type="gene ID" value="ANT_03140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03140"/>
    <dbReference type="HOGENOM" id="CLU_2713553_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="72" mass="8671" checksum="DA1E3D1ABFF73983" modified="2011-04-05" version="1">MPGVRVECRSEYTYPQRPVALWFDQNRVTVAEAEHESRTPRGKLFRVRLEDGRRFELLYEELTDEWSVREIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0B0</accession>
    <name>E8N0B0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561013.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26330"/>
    <dbReference type="EnsemblBacteria" id="BAJ64659">
        <property type="protein sequence ID" value="BAJ64659"/>
        <property type="gene ID" value="ANT_26330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26330"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="OMA" id="LQRYYMR"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="88"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="35263" checksum="9CC502F835CF84B4" modified="2011-04-05" version="1">MEIPLNRERIRVWLLGSRTSYGALFTVFLYLLLIAIGFVYLYPLLFMFVTSIKSPQDLLNPMVQWVPTELYLGNYVKAFRVLNYPVNLMNTILVSVAPSLIQTLVCSVIGYGLARYRFPGKHLVMGLILATFIIPPQTTVIPQMLTYRELGLLGNILSLILPATFGQGYRSAIFILIFYQTFISMPKVLEEAARLDGASDWLVFARIAVPTAIPAYVISIIFSIVWYWNETYLTVIFLEGGIQTLPMQLAKFTQAYENLYPPGMVNIFDRINEAVKMSGTFLNILPLLLMYFVMQKWFVESVERSGITGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0D0</accession>
    <name>E8N0D0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561032.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64679">
        <property type="protein sequence ID" value="BAJ64679"/>
        <property type="gene ID" value="ANT_26530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26530"/>
    <dbReference type="eggNOG" id="ENOG5030608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884668_0_0_0"/>
    <dbReference type="OrthoDB" id="1909357at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="35458" checksum="062ECEEA26994C0A" modified="2011-04-05" version="1">MPFTDRSDLFGAVHENGINRVVRHIMRQRPSLFNYATPFFHNHVEMFCAKFEVDEKVLKAKNPLFTEQELLPILGAPVPIGLNFCLQLSEVAIDFFPGSVFNLPPELGKLSPQRFALHLKGCMGIDCPSRDVIDELLPLIERYLVSQKQLVIGETKENVPGISTHYTPPATTAFNTDREKQHTIPLPTRELICFCLELYAVGYFEWGTVPGSQQTWLKTRLQDLEIVDLQPNNMESAIECYLTTVLKLGILPRLIIPLEKMTLDLTKEFQKMGLPLGRTVQLEPSAVPADVPNNPAVEDDQIKAFFKLTVTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F0</accession>
    <name>E8N0F0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561051.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64699">
        <property type="protein sequence ID" value="BAJ64699"/>
        <property type="gene ID" value="ANT_26730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26730"/>
    <dbReference type="HOGENOM" id="CLU_2246975_0_0_0"/>
    <dbReference type="OrthoDB" id="2093202at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="104" mass="11615" checksum="BC560DCD5C119CFF" modified="2011-04-05" version="1">MYLYVVKWNIHPDKLDAYLNWLNGVIPRTLGIPGVVEFRGYRGLLGASQIVATYEFASLLDWSAWFTHEDNQKVLSELYGVSLNAVGELWGPSPAVPAPIRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0J0</accession>
    <name>E8N0J0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaN</name>
        <name evidence="13" type="ordered locus">ANT_27130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27130"/>
    <dbReference type="EnsemblBacteria" id="BAJ64739">
        <property type="protein sequence ID" value="BAJ64739"/>
        <property type="gene ID" value="ANT_27130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27130"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_4_1_0"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="135"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="253"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ64739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="378" mass="40947" checksum="FCC90A7E39D50E2C" modified="2011-04-05" version="1">MERVIMKVTVSQQHLAHGLGLVSRAVAPRSTLPVLGNVLLATDEGRLRLAATNLELGISCWLGAQIQEEGSITVPARLFADLIGTLPNEMIHLAVNPRSMALSVKCGSSSTELKGIDAAEFPPVPAVDSDHGVLLPVADFKEMIQQVAFAASTEEARPVLQGVQMVISGDEISLAATDGFRISVRQMRLSEPVAQPISVIIPARALQELARIAQEGEVRLIVPPGRGQVVFQMENLQLTSQLIDGNFPDYKVILPRSYKTHTIVSTEALLKAVKQAEIIARMGNGVVRLHLQKFDDRPGQIEISAQSEETGANESLVDANIEGPTLAIAFNVKFLREALEVIKTPNLVLQTNDNRSPARLQPVGDESFQHVIMPMHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N1</accession>
    <name>E8N0N1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cysteine synthase</fullName>
            <ecNumber evidence="4 10">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_03920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4 10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558822.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03920"/>
    <dbReference type="EnsemblBacteria" id="BAJ62426">
        <property type="protein sequence ID" value="BAJ62426"/>
        <property type="gene ID" value="ANT_03920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03920"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_0"/>
    <dbReference type="OMA" id="FWDSGER"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="11">
        <location>
            <begin position="8"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="8">
        <location>
            <begin position="180"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ62426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="312" mass="33141" checksum="A69B466B7A3542AD" modified="2011-04-05" version="1">MRIANDATELIGNTPLVRLNRIAQEAGAAATVVAKLEYYNPAKSVKDRIGVAMINAAEQAGLIKPDTIIIEPTSGNTGIALAFVCAARGYRCVLVMPETMSKERRMLLRAYGAELILTPGSEGMAGAIRKAEEIAASDPRYFMPQQFKNPANPEIHRKTTAEEIWRDTDGQVDMVVAGVGTGGTITGVGEVLKARKPSVRMIAVEPDASPVLSGGQKGPHPIQGIGAGFIPDVLNTQIYDEIVRVKAEDAFATARKMARMEGLLVGISSGAATWAALQVAARPENAGKLIVVIIPSFGERYLSTALFADLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S1</accession>
    <name>E8N0S1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558862.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04320"/>
    <dbReference type="EnsemblBacteria" id="BAJ62466">
        <property type="protein sequence ID" value="BAJ62466"/>
        <property type="gene ID" value="ANT_04320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04320"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014444_0_0_0"/>
    <dbReference type="OMA" id="IVQGHGD"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="31885" checksum="39B8791FBF975C4C" modified="2011-04-05" version="1">MQRERISENVYWFQSEIYAQVTAGAVTGPYWAVVIDTLALPEETLAMRAFIEEELGVPVRYVINTHYHADHCWGNGFFPGATVLGHALTRKLMLEKGAASLESAKRQNPAFKQVKLIPPHITLEEGTLVLRVGKKSLTLFPTPGHSVDGISVLVEEDRVLFAGDAFLPLPYIVDGDAEVLSDTIRKIGKMGLENIVQGHGDIILRGEIDEAVKENLAYLSTIRKQVRAALRKRNPVDALLAIDIESCGKSRVFLGGLAEELHRRNLRFLFRQMQNEEERVEASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W9</accession>
    <name>E8N0W9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-methylisocitrate lyase</fullName>
            <shortName evidence="3">2-MIC</shortName>
            <shortName evidence="3">MICL</shortName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(2R,3S)-2-methylisocitrate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">prpB</name>
        <name evidence="5" type="ordered locus">ANT_04800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3 4">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558910.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04800"/>
    <dbReference type="EnsemblBacteria" id="BAJ62514">
        <property type="protein sequence ID" value="BAJ62514"/>
        <property type="gene ID" value="ANT_04800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04800"/>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_2_0"/>
    <dbReference type="OMA" id="QTELWNK"/>
    <dbReference type="OrthoDB" id="1485205at2"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01939">
        <property type="entry name" value="PrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="297" mass="31946" checksum="6A29C76A46FB2007" modified="2011-04-05" version="1">MAEQSSAGRRLRQALEEEKPLQVVGAINAYAALLAERAGFRALYLSGGGVAAASLGVPDLGITTLDDVLTDVRRITDATSLPLLVDADTGFGSAFNIARTVRSLIKAGAAGMHIEDQVQAKRCGHRPGKQLVSADEMVDRIKAAVDARTDRDFVLMARTDALANEGLEAALERARRYVEAGADMIFAEAVTELPQYAAFVQACGVPVLANLTEFGKTPLYTLDELRAAGVSLALYPLSAFRAMAAAALEVYRTIRAEGTQGRVVPLMQTRAELYEVLNYYAYEQKLDELFGKEKGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Z0</accession>
    <name>E8N0Z0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rnz</name>
        <name evidence="10" type="ordered locus">ANT_05010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558931.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62535">
        <property type="protein sequence ID" value="BAJ62535"/>
        <property type="gene ID" value="ANT_05010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05010"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_0"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="306" mass="34177" checksum="E3674D674EE57665" modified="2011-04-05" version="1">MFEITFLGTSASAPSVKRGLSAQLVKHNEYRFLIDCGEGTQRQILQAGLGFKRLNHILITHGHLDHILGLAGLLSTFMRWETIDHLEIYGPRSALERIDDLLTRVVLRGARPPMPLTLIPITPGVFFEGDDFRVSAFPVHHRGSESLGYLFEERSRRPFLPEKADALGVPAGPLRRDLVEGRAVHLPDGRTITPDMVLGEERPGTRLVHVGDCGETESLLGVVSGADGLVIEATYLEEEREMAHQFSHLTARMAAELAQRAGVKALYLTHLSRRYREKDVLAEAQSVFPNTIVVRDFDTFIIKRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1G9</accession>
    <name>E8N1G9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558970.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62574">
        <property type="protein sequence ID" value="BAJ62574"/>
        <property type="gene ID" value="ANT_05400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05400"/>
    <dbReference type="HOGENOM" id="CLU_715043_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228559" evidence="2">
        <location>
            <begin position="24"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="385" mass="43793" checksum="4102B6400AE73379" modified="2011-04-05" version="1">MKSILRFLSVFALGLSFLLSACAGIAPTPTPTPLPTETATPQPTPTPEPTSTPAPTPTPTVDPCATQPERWTFSLPVDPISKQPYPNFWMNLSPACALKNLEPWIAFSMMIQNGYSIQEAAQTLGLEDNPYLAPLKEGKPQKYVMNFYIKKQKVDDFNLPERYYWWLPYMYHPADMRNYLFDPDTDRYEARLVLWGCARNVTAEVADGVSPELPKVTFQAVCAVRKYYPGVQSYWWEMDFPEGTAGGLTRKFIPGKRAFEPKYKQYGEGVHGAKPDQPAYAGMLYYAYIGNGQWYYIGEDNAFDLVGFDSVEEMEAALQRNLELVPGSQVWDLEWLKQTYGVDARPVPQEYKTGFDRYQSDSAFKALVDRALEKQKESLDRYSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1H4</accession>
    <name>E8N1H4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbsB</name>
        <name evidence="3" type="ordered locus">ANT_05450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558975.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62579">
        <property type="protein sequence ID" value="BAJ62579"/>
        <property type="gene ID" value="ANT_05450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05450"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_2_0"/>
    <dbReference type="OMA" id="QAVFAHN"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228054" evidence="1">
        <location>
            <begin position="26"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="39"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="32081" checksum="EF2CD478515AB50A" modified="2011-04-05" version="1">MKRSIVYLLLAFVLVLAACTPAAQTATQAPQQGGEITLGLVLSTLNNPFFVTLRDGAQKAADAAGVKLIVVDAQDDSAKMTAGIEDLINKKVSALLINPTDSDAVVPAIQKANEAGIPVFTVDRGSNGGTVVSHIASDNVAGGKMAAEFLCKAIGGKGNVVELQGIAGTSAARDRGQGFNEYMSTSCKDAVIVAQQTADFNRDKGLKVFENILQAQPEIAGVFAHNDEMILGAIQAAEAAGRTGIVFVGFDAIDDAVQAVKDGKLAATVAQQPAVMGQMAVETAVKYLKGEKVDASIPVPLNLVTKDTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I7</accession>
    <name>E8N1I7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">surE</name>
        <name evidence="7" type="ordered locus">ANT_05580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558988.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62592">
        <property type="protein sequence ID" value="BAJ62592"/>
        <property type="gene ID" value="ANT_05580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05580"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_2_0"/>
    <dbReference type="OMA" id="DCVHIAL"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="257" mass="27654" checksum="F7003BCD6507440B" modified="2011-04-05" version="1">MPHVLITNDDGVHAPGILALAQALQTLGKVTVFAPDRNWSASGHDKTMDRPLRVRETHLADGTPALTSDGSPADCVALALLGVIQEPVDVVVSGINAGENLGQDMTYSGTVTAAMEGALAGLPAVAVSMKLPANGSKPDFSAAAQIARRVVERVLRFGLPPRVVLNVNVPPLPLDQIKGIRITRLGERIYRDALVTRYDPRHKPYYWIGGEPPDGVPEEGTDIGALAEGYASITPLHLDLTLYSLMESLRQWNWEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1L5</accession>
    <name>E8N1L5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559015.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05860"/>
    <dbReference type="EnsemblBacteria" id="BAJ62620">
        <property type="protein sequence ID" value="BAJ62620"/>
        <property type="gene ID" value="ANT_05860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05860"/>
    <dbReference type="HOGENOM" id="CLU_920758_0_0_0"/>
    <dbReference type="OrthoDB" id="2022437at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021530">
        <property type="entry name" value="DUF2877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11392">
        <property type="entry name" value="DUF2877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="33311" checksum="6A687A7A494B9BAD" modified="2011-04-05" version="1">MEHSPSAYVRMYRCQSIGYAALKGLSFPTTGRVTGSTSKGVFVLVPPQRVFFLSYESYRGPLTLNLSPRPAEPLPVYIGQEVHLEADEISLPTLNTHISLSDENLWLPPVPPARIRSGEELWASIQRLSESALYVHRGVGFVPLLAFIMDDPHPPTIPAILQPSIASILILKNLFTQPLEVSMPALTGLMGSGRGLTPSGDDLIVGLMLLLSRMPGMDSLHETLEALHRQIMEIAFEKTTALSANLIACACEGSADERLIQAVDGFLTGSLSESAVLATLQEYGSSSGVDALTGMALALRALKVANYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1P7</accession>
    <name>E8N1P7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LytR family transcriptional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62652">
        <property type="protein sequence ID" value="BAJ62652"/>
        <property type="gene ID" value="ANT_06180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06180"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559792_0_0_0"/>
    <dbReference type="OMA" id="MMIDFAG"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="129"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="394"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="487" mass="53249" checksum="14245079A1F4556F" modified="2011-04-05" version="1">MQSMARVSSRYRQSQPSLDRTTLILLGVFVVLALATAVVAYLWARNLFSSWTMTGMGNAPAASSPAQSGEQNQGNSNVPLPEGPLQNNGAGPEPKPWDGKTRVTLLVMGLDYRDCEDNFAECDQNGASRTDSMMLLTVDPVSKTAGMLSIPRDLWVQIPGFDYGKINTAYFLGEVYKLPDGGPGLAMRTVEQLLGVPIQYYALVDFNAFVRIIDELGGVKIRPKERIKLDPIGPNNTIWLDPGVYVVDGATALAYARNRYTEGGDFDRAARQQEVLISIRDRVLQFNMLPTLIAKAPRLYAEVQSGVRTNLTLEQIVQLAWLSQQIDKENIKRGIIGPPNYVTFSTSPDGQAIEIPVTDQIRVLRDEIFATGGPVGPAAVTDDPEELVKQEAARILVKNGTTTGGLAGRTAEYLRSKGLNVTGEGNADQVYSFNTLIDYSGKPYTMTLLLDMLGKDNTRVISRYDPNAQVDIEIILGTPFAQSNPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q9</accession>
    <name>E8N1Q9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_06300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559059.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06300"/>
    <dbReference type="EnsemblBacteria" id="BAJ62664">
        <property type="protein sequence ID" value="BAJ62664"/>
        <property type="gene ID" value="ANT_06300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06300"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_3_0_0"/>
    <dbReference type="OMA" id="GIFQLHH"/>
    <dbReference type="OrthoDB" id="1543624at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="34"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="285" mass="32144" checksum="9D040C2112B7BC64" modified="2011-04-05" version="1">MTTVKNHSYPITYLRPASGWMPLDLAALWEYRELIYFLTWRDIRVRYKQALLGIGWAILQPVFHMVLFTVIFGRLAGLKPDAGIPEQLYPIFSFAALLPMQLFQQALQRSSISLVQNANLLTKVYFPRLIIPLSAAGAALVDFFFAMLVLGGLMVAYQVPVTARLLWLIPLTLLAVLAALAIGLWLSALNVQYRDVQHMIPFLIQAWMYASPVAYSIDVIPESGIWRWVYALNPMAGVIQGYRWALLDATPPAGFLWVSVAVVVVLLISGLYYFRAMERTFADTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R7</accession>
    <name>E8N1R7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acylneuraminate cytidylyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559067.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06380"/>
    <dbReference type="EnsemblBacteria" id="BAJ62672">
        <property type="protein sequence ID" value="BAJ62672"/>
        <property type="gene ID" value="ANT_06380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06380"/>
    <dbReference type="eggNOG" id="COG1861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072501_0_0_0"/>
    <dbReference type="OMA" id="FIIQARM"/>
    <dbReference type="OrthoDB" id="1345588at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="28925" checksum="8B280D4B6E8FE0F5" modified="2011-04-05" version="1">MTNTVILIQARMTSSRLPGKVLLDLGGQPALAWCVERCKQARSAQRVVVATTTNASDDPVAALCHQRGWEVFRGSEFDVLDRFVQAARWAQADVVVRVTADCPLIDPAEIDRVVEAFFATGADFAANRLPPPWKRTTPIGLDTEVCRMAALERAWREAAQKFEREHVMPYLYDEPGRFRVHIADWEQDLSHHRWTLDTPEDYQFLREVVKRLGNRMDVRWQDVLALLEAEPQLMQINAGVRHKSGLEHDPRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T5</accession>
    <name>E8N1T5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_06560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559085.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62690">
        <property type="protein sequence ID" value="BAJ62690"/>
        <property type="gene ID" value="ANT_06560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06560"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_539314_0_0_0"/>
    <dbReference type="OrthoDB" id="1783649at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="86"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="505" mass="57736" checksum="2E44816DC4A144DA" modified="2011-04-05" version="1">MMEKHRGFSRFWNRRTGEVLFVLALLALGLVIRLYDVDDPPLDFHPTRQLHSLILARGMYLPEAPNVPAWQKERARLQAQAEGIVEPPILEMLVVQTYRLLGREVPFVGRLYSLSFWVLGALGGFLLMRRWLSVPVAGVGLGLMLFFPYGVIASRSFQPDSLMTALILWSLWALAGWRQTDSWRWALAAGVLSGLTLLVKATGGFLLFFPLAVLLWAERKRFSRRTWMQLLGVGVLASLPLLAYSLYGWFVAGYLQQQMSLRFFPQYWLDPVFYLRWASLLVQTFGLPWLVFALLGTMVLPVPLRAVAWGVWLGYLALGLALSHHISTHDYYSLPLVPFLALGVAGLMQVFLEHLPGPRRWWRAGAALVLIATAGWMLYESRTILKKADYRAEPAFWQMLAGQMGDDARVIGLLPDYGARLTYWGWITPANWWTQAEVDLRRRAGQNVDVQALLQEQTRGKDFFVITLMDEFQRQQELQQFLAQYPLFRQGDGYLIVDLRTKRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V8</accession>
    <name>E8N1V8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559107.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06790"/>
    <dbReference type="EnsemblBacteria" id="BAJ62713">
        <property type="protein sequence ID" value="BAJ62713"/>
        <property type="gene ID" value="ANT_06790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06790"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007014_0_0_0"/>
    <dbReference type="OMA" id="LIMYLAR"/>
    <dbReference type="OrthoDB" id="1812533at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="2">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="276" mass="31593" checksum="687E342B3BDD8938" modified="2011-04-05" version="1">MALKGNLRDFTITQLLNLINLAQKTGLLVIEGPGETARINFRQGKLAYAQLGDEDGSLASILYKTRKISQSQYRLLLERASGMTDKELGLLLINAGYLTQDDILTSLQTYFIDVVRRLFTWVEGFFRFDQDVTPPDGKITIRMDLENLIIEGARQLREWEQLQEEIPSLDMALKFTDRPGTNIQKVNLSLEEWRVVSYVNPKNTIRQIARATKMNDLEIRRVVYGLIQAGLVEIVRPEGAPAPRPQTQQLPRQFPTPDKEEQKSLVNRLINRIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N221</accession>
    <name>E8N221_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29420"/>
    <dbReference type="EnsemblBacteria" id="BAJ64968">
        <property type="protein sequence ID" value="BAJ64968"/>
        <property type="gene ID" value="ANT_29420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29420"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475427_0_0_0"/>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225227" evidence="1">
        <location>
            <begin position="24"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="84"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="223"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="345"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="483"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="573" mass="61034" checksum="B05138459BDC8A74" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N227</accession>
    <name>E8N227_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561318.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29480"/>
    <dbReference type="EnsemblBacteria" id="BAJ64974">
        <property type="protein sequence ID" value="BAJ64974"/>
        <property type="gene ID" value="ANT_29480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29480"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_16_2_0"/>
    <dbReference type="OMA" id="IIAYHVK"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="170" mass="18681" checksum="AAEB078A08160D0E" modified="2011-04-05" version="1">MAGKARFCLQCGARLETRFLFGRDHPVCPQCGWIYFEDPKVAVAVLVERGEEVLLVQRLNPPLQGLWSLPAGFMDAHEDPARAAERECLEETGLVVRVTQLLGIVPGREHPSGADIVIAYRAEVVEGDLQAGDDAGKAAFFPRSALPPLAFRATQLILEGKIPQTHQHME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N242</accession>
    <name>E8N242_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561333.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29630"/>
    <dbReference type="EnsemblBacteria" id="BAJ64989">
        <property type="protein sequence ID" value="BAJ64989"/>
        <property type="gene ID" value="ANT_29630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29630"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_867776_0_0_0"/>
    <dbReference type="OMA" id="HIHAQRP"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="201"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="320" mass="35077" checksum="0EC9A545109558ED" modified="2011-04-05" version="1">MPWDTPLPVLIWALTGLPLSLLALFKPPAGKLPAYLIALDILLLNLYFFHTAPWAVVNYYLRALPFLLSLAVIARMIHATRSQPFFPQTKRGWALTAILLVLAVPPAFMDAQALRSYRYPASAGPSMYALPPLQGGLHVFINGGNGLDGWGMNNAYRDWLGRQTGNDRTAGYSVDLVKLAASGAMSRGILPRDFRRYETFGERVYSPCLGQVVKVQDGIADVPPFSDSGSALGNYVVLKCAQFSVTLANLRVHSISVKEGELVALNTPLAEVGNSMANTFPHLHMRVTTGGESGTAQPAPILFETLFDFSYRARNDFYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N254</accession>
    <name>E8N254_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561345.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29750"/>
    <dbReference type="EnsemblBacteria" id="BAJ65001">
        <property type="protein sequence ID" value="BAJ65001"/>
        <property type="gene ID" value="ANT_29750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29750"/>
    <dbReference type="HOGENOM" id="CLU_2115896_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="114" mass="11813" checksum="3466A2BBDA1F28ED" modified="2011-04-05" version="1">MEKRFKVLRFMGTLYKILGVINGVVTLILAVGICAVSVLGGASMADFAREYGMHGTEVFGALGGVLLGGGVLILGGLSAVFVYALGEGVYVLIAIEENTRAAAMRLQAPIPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N259</accession>
    <name>E8N259_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="9">2.8.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">miaB</name>
        <name evidence="13" type="ordered locus">ANT_29800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561350.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29800"/>
    <dbReference type="EnsemblBacteria" id="BAJ65006">
        <property type="protein sequence ID" value="BAJ65006"/>
        <property type="gene ID" value="ANT_29800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29800"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_0_0"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="144"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="378"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ65006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="438" mass="49766" checksum="74C764FB58880FFB" modified="2011-04-05" version="1">MKYHIWTEGCQMNVADSQRVASALEHLGYSVTPKPEEADVIVLNTCVVRQSAEDKAYGRLNSLRPLKEKNPHLVINLMGCLVGIRNNDALRKRFPFVDVFSPPSDPSPLVAFLTQSEVRAMEESATATRYAYMDGDLVLPEVERGKLVSAHIPVVYGCSHACTYCIIPYRRGIERSRPPEDILAEARALVRQGVKEITLLGQIVDRYGKDNPAYPTLAGLLIRLSEIEGLERIRFLTSHPNWMTDELLDAVASLPKVMPHIEVPAQAGDDTVLENMKRGYTAEQYRELIARIRERIPGVSIATDIIVGFPGETEEQFMNTYRLLEDLRLDVAHLARYSPRPGTVSARRMKDDVPEEEKMRRFRMLEELQERIVGEINARYLGESVPVLFEEKVKQRWKGRTPTNKLVFVESEEDLHGQIREVKITWTGPWSMIGSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N265</accession>
    <name>E8N265_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561356.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29860"/>
    <dbReference type="EnsemblBacteria" id="BAJ65012">
        <property type="protein sequence ID" value="BAJ65012"/>
        <property type="gene ID" value="ANT_29860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29860"/>
    <dbReference type="eggNOG" id="ENOG5030TSN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1631951_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="162" mass="18491" checksum="B6096C1F0C09C4D3" modified="2011-04-05" version="1">MRQDRFLTAILAGIGVLILLSLSLYFIRRVDLTYGAEDTPSGVLRNYIVAMQKRDFERAYTYLADQENKPSLAQFRTPLEGYLYRELSTTAIRIVEESVQGDQATVSVQLLRGQNQPFTTAFRDTQTATLVRQGGAWKITSVPYPYWAYEWYPPEPAKPAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8N279</accession>
    <name>E8N279_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="11" type="ordered locus">ANT_30000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561369.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30000"/>
    <dbReference type="EnsemblBacteria" id="BAJ65026">
        <property type="protein sequence ID" value="BAJ65026"/>
        <property type="gene ID" value="ANT_30000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30000"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_0"/>
    <dbReference type="OMA" id="IHAIIND"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03280">
        <property type="entry name" value="ABC_MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="10">
        <location>
            <begin position="731"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="512"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="342"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ65026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="808" mass="89375" checksum="0CB0784418D850C9" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N291</accession>
    <name>E8N291_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_30120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561379.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30120"/>
    <dbReference type="EnsemblBacteria" id="BAJ65038">
        <property type="protein sequence ID" value="BAJ65038"/>
        <property type="gene ID" value="ANT_30120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30120"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_773037_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="244"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ65038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="358" mass="39632" checksum="8784710C3CB3E984" modified="2011-04-05" version="1">MTTPGDERTAHEAVQQAIRALRRRDRAQARYWAQQAVRLAPEDEQGWLALAAVASPQGSVAYIRRALELNPTSPQARQAMHWAIRRLRAQPAAYSLAIHPGLTLPALDLEETRPLPAAPAPATAPRPFTLPQKWMRTVQGMALALFLVMLTVITLGFTGGWAPWTRAYAAERPAMALLKPTLTPTHTPTATPTATPTATPTPTPTETPTPTPTHTPDPTDTPEPTDTPEPQRDAPAPPIEADGRWIDVDLSEQKLYAYEGDTLVNSFIVSTGTWLHPTVQGQFRIYVKYRYADMSGPGYYLPDVPYVMYFYKGYGLHGTYWHNNFGTPMSHGCVNLRTEDAGWLYNWASVGTLVNIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B5</accession>
    <name>E8N2B5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559115.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06870"/>
    <dbReference type="EnsemblBacteria" id="BAJ62721">
        <property type="protein sequence ID" value="BAJ62721"/>
        <property type="gene ID" value="ANT_06870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06870"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_0"/>
    <dbReference type="OMA" id="WHHGTDK"/>
    <dbReference type="OrthoDB" id="1435073at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="113"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="343" mass="38404" checksum="4B0D8EE416E96E77" modified="2011-04-05" version="1">MEINLRAPVEVLITLPLKEEVLQPVRDLSPHINLTVIPARRPEDIPAEVWAKTEVLYTDRVLPAPEQVPALRWLQFHFAGIDFAVDSPLLQKEDLKVTNLSGAAAAQTAEFALTMMLALAHRLPALMQAQSRAEWAHDRWERFRPVELRFSTVGIVGYGSIGRELARLLQPLGVKVLACKRDVRHPQDEEYIPEGMGDPQGIYFTRLYPYQALRTMFRECDFAVVTVPLTPQTRGMIGADELAALKPGAFLVVVGRGGVVDETALLEALQEKRLGGVALDVFAEEPLAPTSPLWKAPNLIISPHIAGLSVHYDERAMALFATNLRRYIQGERLYNLYEPERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2M7</accession>
    <name>E8N2M7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_07990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559225.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07990"/>
    <dbReference type="EnsemblBacteria" id="BAJ62833">
        <property type="protein sequence ID" value="BAJ62833"/>
        <property type="gene ID" value="ANT_07990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07990"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373323_0_0_0"/>
    <dbReference type="OrthoDB" id="1262173at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="727" mass="80231" checksum="B254AB5CB359D072" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Q5</accession>
    <name>E8N2Q5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_08270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08270"/>
    <dbReference type="EnsemblBacteria" id="BAJ62861">
        <property type="protein sequence ID" value="BAJ62861"/>
        <property type="gene ID" value="ANT_08270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08270"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_6_1_0"/>
    <dbReference type="OMA" id="HGPYYTF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="390" mass="42604" checksum="8AE837907C66E31B" modified="2011-04-05" version="1">MDTFNAATHPNQKPLQTLWMLFFLLYASIGVSFTFINVYYASIGLTGTQIGLLSTIGALTSMVGAALWGFLSDRTGQARWIMAIGGFLAGGLFFLTPLMRTFTALVILTIGIGIFASSAFTLIDALTLTLLGEHRGQYGRYRLGGSLGYILTASLGGFIYQRLGLALIFPVYLFIMILFGIISLRLPVIHLPSSSQQKASLKGMVTQPAWLLFMFCVFLVWTASAGFLNFLGVTIQDMGGASSLIGLAGTIAAITEIPFMYYSGWFLQRLGVTRMLWISMAFYTLRLGLYSIMPSPYWVLGINMMNGPTYVFFWNSAISYAFQLAPAEYKATAQGFFIAVTNLSAMVGALLSGWLYDTSGPAGMFRVLGLFCLAAFTLFAFNRSPRTATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N304</accession>
    <name>E8N304_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_31280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561495.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31280"/>
    <dbReference type="EnsemblBacteria" id="BAJ65154">
        <property type="protein sequence ID" value="BAJ65154"/>
        <property type="gene ID" value="ANT_31280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31280"/>
    <dbReference type="eggNOG" id="COG4087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142246_0_0_0"/>
    <dbReference type="OMA" id="PYIGIGN"/>
    <dbReference type="OrthoDB" id="1842462at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="156" mass="16545" checksum="C360543872B02097" modified="2011-04-05" version="1">MIELTVPGQGVIRLQHLVLDVNGTLAVDGRLIEGVRPLLDQLRDRLEIHLITADTHGGQAALDRQLGLQAHRLQAGGEAEQKAAFVRSLGAEQVVAIGQGANDALMLREARIGICVLSPEGTAVSTLQSADICTAGILPALELLTKPLRLVATLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N315</accession>
    <name>E8N315_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31390"/>
    <dbReference type="EnsemblBacteria" id="BAJ65165">
        <property type="protein sequence ID" value="BAJ65165"/>
        <property type="gene ID" value="ANT_31390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31390"/>
    <dbReference type="HOGENOM" id="CLU_693787_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="397" mass="44542" checksum="8EE4D04F18C97EB2" modified="2011-04-05" version="1">MQYRQSAHVASPGVVADSFPPPGFPYPLRVLKTGMKRPLLFFKALWTSPAYPLLLAVCWGLSGFLPPIRDLSAVHALTFLIVASVGVWMFRARKVLCLNEFYLRLPAAREANALMTFGALTLVFLPLLIRVSGLSWLSMQYTLSLLLLALLAEGSFLSGLFLPLALISAFSACPSYQTSGVILFGMPFLAVLALWVTRRLQAWQVRGFRVQPRYLLIGGGALLLFQWLVSVRQSDMRFVLSGEYIGFRNPDFEHPLFFTLFLTAAVLFVFLPFLNLLGFRSAEQALGSVRALRRTPCTRRLWGVLLGILWQLPLVPLFLGLRFVEVSPQSIWILLLMGVFVNTLWLTAEDSNWAGYAALLYLGLVHTFISANGLWLFFCALGLILLFYDMDMKKVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N362</accession>
    <name>E8N362_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">nuoN</name>
        <name evidence="8" type="ordered locus">ANT_08420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559268.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08420"/>
    <dbReference type="EnsemblBacteria" id="BAJ62876">
        <property type="protein sequence ID" value="BAJ62876"/>
        <property type="gene ID" value="ANT_08420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08420"/>
    <dbReference type="eggNOG" id="COG1007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_5_0"/>
    <dbReference type="OMA" id="NAWAPDA"/>
    <dbReference type="OrthoDB" id="1664448at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="483" mass="52013" checksum="2936BFD62A9A1F49" modified="2011-04-05" version="1">MMITLNDVLTLLPAVVLLAWGVMMLVVDLFLPKERKAIIPLLAGLGAAAGLGVNLALTGYSQTGFNGMVVLDGFASFTNTLLLIAALFAVMLAYDYMRRMNIERSECCALMLISTAGMMMMVQAYDLIILFLALELFSIPLYVMSGLIRGKISSEEAALKYFLLGAFSSAFLLYGVAFLYGATQHTNLAGIVAAMQSGTANYIFLMLGVALLLVGLAFKLAIVPFHSWAPDVYQGAPTPVTGWMSVSVKIAALAALLRVFVVAFPSLSAQISPVLGVLAALTMIVGNVLALVQTNIKRLLAYSSIASAGYLLMAFVPYGQGEVASHAVAAGLFYMVGYLFTSFAAWAVVAAVEKAEGKDLEITSYAGLARRHPWLAVAMLIAMVSFIGVPPTLGFWGKFYLFRTALEGGLVWLALIGLLTSLFSAYYYLRVVVVMFMQPGEVEARREVWVNLLAVVSAGATLLLAFIPWQILDWATAAFLRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N378</accession>
    <name>E8N378_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_08580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559284.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62892">
        <property type="protein sequence ID" value="BAJ62892"/>
        <property type="gene ID" value="ANT_08580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08580"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252921_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="189"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="1285"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1423" mass="159948" checksum="6F6EBBBE98594F38" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N386</accession>
    <name>E8N386_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ordered locus">ANT_08660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559292.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08660"/>
    <dbReference type="EnsemblBacteria" id="BAJ62900">
        <property type="protein sequence ID" value="BAJ62900"/>
        <property type="gene ID" value="ANT_08660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08660"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_5_0_0"/>
    <dbReference type="OMA" id="VVHVFQK"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="105" mass="12159" checksum="0D2F66C761660249" modified="2011-04-05" version="1">MVHALEEKKGEQIVLMDIHEIAVFADYFIFCNGTSNRMIESLVESVSEAAHKLFHLDVKVEGLPDDGWMVVDLGDVVIHLFSPDQREYYRLEQLWDKGKVLLRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N394</accession>
    <name>E8N394_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NarL family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_08740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559300.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08740"/>
    <dbReference type="EnsemblBacteria" id="BAJ62908">
        <property type="protein sequence ID" value="BAJ62908"/>
        <property type="gene ID" value="ANT_08740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08740"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="DVWVPPD"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="216" mass="23578" checksum="16AE41E21BBAF2FC" modified="2011-04-05" version="1">MSKITVLIVDDHSIVRAGIRTYLETQSDLEVVGEAASGKEAVQLAAELVPDVILMDLIMPEMDGVEATQRVRQISPRTQVIVLTSFHEDTHIFPAIKAGALSYLLKDVSAEELGEAIRAAARGEAVLHPQVAARLVKEMRGTPAEKPNPYTALTEREQEVLKCIAQGMSNAEIAAHLVVSEKTVKGHVSNILSKLHLADRTQAAIYAWKEGLIRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N399</accession>
    <name>E8N399_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secretion protein HlyD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_08790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559305.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08790"/>
    <dbReference type="EnsemblBacteria" id="BAJ62913">
        <property type="protein sequence ID" value="BAJ62913"/>
        <property type="gene ID" value="ANT_08790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08790"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_2_0"/>
    <dbReference type="OMA" id="TGKIQPE"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228610" evidence="3">
        <location>
            <begin position="25"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="222"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="111"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="221"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="465" mass="51532" checksum="0F2172D0DE3FA523" modified="2011-04-05" version="1">MKRWVFYLFSVVLMGLLVACSSNTETSNYETAKLETGSISAVITTSGAVRPVRSADLTWQISGKVQEVHGEIGDTVQDGQELARLAEDSLPQNVLLAWNDYLQAEEYLKDLQDTQPELAQAQMELAQAQEEYEKVEKRYRNFNPERRNVSQATIDTAKADLALAEKNLEMAQKYFDLFKGRDANDPERAEALKMLAKAQQARDSAYFNYLYVTGKPSNTEAQKIQAELALAKSRLDQAKKKVEELSKGVSTLELTAAQARLRAAQQTLDQIVLKAPFAGIITNRRIQPGDVVTAGTLAFQMEDRSHLYVEVNISEIEINDIHLEQEATLTFDALPEKTYHGRVVQIGLSGNNQQGAVTYPVTIEITDADENIKSGMTAMVQIETRKLDQVLLVPNRAVRVLNGQRVVFVKKNTGLPEAVPITLGVSSATHSQILKGDVKEGDEVILNPDLLMQLQEQGGNGVVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A5</accession>
    <name>E8N3A5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-galactoside ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_08850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08850"/>
    <dbReference type="EnsemblBacteria" id="BAJ62919">
        <property type="protein sequence ID" value="BAJ62919"/>
        <property type="gene ID" value="ANT_08850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08850"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_0"/>
    <dbReference type="OMA" id="FIGPHVY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="167"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="376" mass="42617" checksum="48DCC238428FFD39" modified="2011-04-05" version="1">MANKNPKSASAVILRAREHESYGTLVWRRFRKSKIAILGGLMVIMLIVLAIFSDFFAPYDPVKLNMRNGYIPPHKVHFIDAEGKFHLRPFIYGWKQVLDENMFPRWVEDTSKAYPIYFFVKGWDYKLLGLIPMNIHLYGLKDPEGMIFLLGSDKFGRDIFSRSCLAGRISLSMSLFGTIISVAVGSVLGVISGYFGGAVDTYMQRFVEFVQSFPQLPLWMALAAIIPDTWDQFAVFVVMSSIFALLSWTLLAREVRGKVLALRETDFVLAAREMGASDWRIIFHHLYPNTISHTIVVLTLTIPTIILAESFLSFLGIGIQEPLVSWGVMMREAQTIQTLGFNIWIISPVFFIFMAVLGWNFLGDGLRDAADPYTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B2</accession>
    <name>E8N3B2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_08920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559318.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08920"/>
    <dbReference type="EnsemblBacteria" id="BAJ62926">
        <property type="protein sequence ID" value="BAJ62926"/>
        <property type="gene ID" value="ANT_08920"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08920"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780058_0_0_0"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="124"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="302" mass="34688" checksum="3CF8D215992BDAEF" modified="2011-04-05" version="1">MTPETPSSPVAHLTVHTPLMPAILTWEIYLKDQGRSPHTIKAFMGDLNLLASFLPPDRTLGSITTQDLNHFLQWLEKGRGIPCSPKSLARRITSIKAFFRWLQRSGVLLNDPALRVIQQSVISPLPEVLTPEEVEAVLEVARNWRSRSKPDARPYTLVKLLLETAIKKSECLAITRNHIDPEGKEGPVLYVRYASPSNRYKERNLPLSEEWIEAYQEYLAQYQPADQIFPWSPRRLEYILEDLSEAAGLAKHLSFDMCRWTSALMDWKNGMEGDQIRQKLGVSKIQWREISMKLRQLAEQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3C1</accession>
    <name>E8N3C1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative sugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559327.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62935">
        <property type="protein sequence ID" value="BAJ62935"/>
        <property type="gene ID" value="ANT_09010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09010"/>
    <dbReference type="eggNOG" id="COG2222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_2_4_0"/>
    <dbReference type="OMA" id="AYDTRHY"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="194"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="37141" checksum="21C9ACFD015D3930" modified="2011-04-05" version="1">MAYREDILQQPQAVLNTLNRWGMTPSLEQVVHRLRSGEYRRVVLTGMGSSLYALIPLWYRLLDAGIQTLWVETGELLHYGAEWVKPEDLLVVVSQSGRSAEVVELIKRNPSPILGVTNTPESPLAQTAETLVLTDAGEEATVSCKTYVATLTSLALLGEAFLGNDLLQLQRGLEATAFQMEAYLSRVDDHVNHLAGILQGIEHVIYAGRGVSLASAETAGLITKESVKIPAEGMSAAAFRHGPFELISPRLFVLVFEGEEPTRALHRNLVNEVNRLQGRAQLAGESAQDEVFHLQPLNIHVRPLMEILPVQMMTLALAHLRGRIAGEFTLASKVTDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E0</accession>
    <name>E8N3E0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_09200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09200"/>
    <dbReference type="EnsemblBacteria" id="BAJ62954">
        <property type="protein sequence ID" value="BAJ62954"/>
        <property type="gene ID" value="ANT_09200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09200"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_4_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="543" mass="62675" checksum="D972DBAFB50F3F20" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H8</accession>
    <name>E8N3H8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559383.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62992">
        <property type="protein sequence ID" value="BAJ62992"/>
        <property type="gene ID" value="ANT_09580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09580"/>
    <dbReference type="eggNOG" id="ENOG5032V4J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101811_0_0_0"/>
    <dbReference type="OMA" id="WLNKTHI"/>
    <dbReference type="OrthoDB" id="1571706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="237" mass="27283" checksum="956C1854459939B1" modified="2011-04-05" version="1">MTHQDWIVMTCPTCGAKMAPSLLEPERYQCQYCGNEYLLKNLLGKPESTVGKIRPRLAPPESVKIERETDRVRMIHRWFSFKYIPLAFFALAWDVFLIFWYGMAFTTGAPWIMICFPIAHVAVGVGLTYSVLTGFFNRTIVELTRDELAVWFEPLPWLGEKTLPVAEISQFYCKKKVSQNSKGTSVNYALHAVMRDGKDVKLLENFDSPEIAQFIEQQLETWMKIPDRPVAGEFRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N2</accession>
    <name>E8N3N2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmC</name>
        <name evidence="6" type="ordered locus">ANT_10120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559437.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63046">
        <property type="protein sequence ID" value="BAJ63046"/>
        <property type="gene ID" value="ANT_10120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10120"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_2_0"/>
    <dbReference type="OMA" id="RFQMATS"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="69" mass="8223" checksum="4281520452A7C9A0" modified="2011-04-05" version="1">MKPSEIRQLTTEELRAKLMDARQELMNLRFQMTTGQLTDTSRLGKTRRLIARFETILRERELAEERGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3N4</accession>
    <name>E8N3N4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rplN</name>
        <name evidence="6" type="ordered locus">ANT_10140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559439.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63048">
        <property type="protein sequence ID" value="BAJ63048"/>
        <property type="gene ID" value="ANT_10140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10140"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_0"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="123" mass="13419" checksum="134890DE284DC682" modified="2011-04-05" version="1">MIQQETRLKVADNTGARELLVIHIMGGSTRKYGEVGDIVVATVKSAAPQGAVKKSEIVKAVIVRCAKEWRREDGSTIRFDDNAAVILDSSGQNPRGTRIFGPVARELREKGFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Y8</accession>
    <name>E8N3Y8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559541.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63152">
        <property type="protein sequence ID" value="BAJ63152"/>
        <property type="gene ID" value="ANT_11180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11180"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082381_1_0_0"/>
    <dbReference type="OMA" id="TLPGGWC"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="206" mass="23400" checksum="F15C6939D7A0BC6C" modified="2011-04-05" version="1">MSVSLLNWARQIQSIAQAGLSYAQNPFDRERYEKLMEIAAQLMALESLDPPEKIHAILRAEAGYLTPKVDVRAGVIQDGRILLVREMLDGGRWTLPGGWVDPGDTPSSAVEREVREETGYEARAVKLVAVFDREHQGHPPYLFSIFKLYFLCELRGGEPRGSIETGESRFFGRCEIPELSLARTLPQHIEMLFRHYEQPDLPAEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N415</accession>
    <name>E8N415_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_11450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559567.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11450"/>
    <dbReference type="EnsemblBacteria" id="BAJ63179">
        <property type="protein sequence ID" value="BAJ63179"/>
        <property type="gene ID" value="ANT_11450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11450"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="OMA" id="WYAYAMI"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="301" mass="34463" checksum="301B3393DB7ED9B2" modified="2011-04-05" version="1">MENKKRKINLIPYLFILPHLIFFAIFVGYPFFNGLYISFFQYDYLRPEATTFVGLKNYIDLFTPGTVKFLEFWNSMKVTVTFVIWSVPFLVLIPLGLAVLLNLKIPGTNFFRATFFAPWVLSVAVISLIWWWIFQSEGGLLNYYLKMFGLPTPRWLSTMPYAMITIVVATVWWTMGYNMIIFLAALQDIPPELYEAAEIDGANSWQRFINVTLPMLQPVLVFIIIITIIASFNLLGQPMMMTRGGPAQPTGGGATEPVMLRIFTEGFVRPFQGSAAAMSVIVALIMVIFSYANFRIFRQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N416</accession>
    <name>E8N416_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559568.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63180">
        <property type="protein sequence ID" value="BAJ63180"/>
        <property type="gene ID" value="ANT_11460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11460"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_0"/>
    <dbReference type="OMA" id="AWGGSSH"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225268" evidence="1">
        <location>
            <begin position="31"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="438" mass="47108" checksum="B6C50C13FAEC6933" modified="2011-04-05" version="1">MKLFSRYFLPIMLILSILLTACGSTTTPTAAPQTGEQPAEQNACGKVELQYWNPFTGPDGPYMGEMVEAFNASHPDIHVTMTSQGEYYTQISTAAAADTLPDVAIIHADQVATLAFRNVLRPIDDLVAEMGLSGDDYPEAVWAAGEVAGHRYSIPLDIHPMTMFYNADLLKSAGFENPPANAEEFEAIAAALTTEETKGFDITGGFPVQQIFQQMLHQFGGTEFNEDGTQATWNSEAGVKALQWMKDMQNKYSAPNLEVDAELNAFKAGTVAMIWNGIWQTTNVTGEGVEFDGRATSVPQIGPYMAVWAGSHQFTMPVHKNIDPCKDKAAAEFIKYMVANSVTWAKAGQIPASKSVRQSAEFLAIEPQASIAKSVDYAFFPPAVPGITDAFGPLGEAVGAVMNGTATDIKAALDDAAKRANEILAQNKATYGDAPKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N433</accession>
    <name>E8N433_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559585.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11630"/>
    <dbReference type="EnsemblBacteria" id="BAJ63197">
        <property type="protein sequence ID" value="BAJ63197"/>
        <property type="gene ID" value="ANT_11630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11630"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_1_0_0"/>
    <dbReference type="OMA" id="NWAVGPE"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="334" mass="37808" checksum="A77C0C94F2881FCB" modified="2011-04-05" version="1">MSRTTISHRERLETCLSGEIPDRVPVALWRHFPVDDQTPEGLAAATAAFQRLYDFDFIKVTPASSFCLKDWGAEDEWRGHPEGTREYTRRVIQQPEDWAKLPLLDPTSGHLGDQIHCVRILTAEFAPHTPVVQTIFSPLAQAKNLIGQENLLIHLRRYPEALHAGLERITQVTIRFIEELRKTAIDGIFYAVQHAQYGLLSEEEFETFGRYYDLRVLEAVKGWWLNIIHLHGNEVMFNKVADYPCTVLNWHDRQTSPSLSEAKQTYSGVICGGLRQWETLVLGTPEAVFEEAREAILSTEGERFILGTGCVLPVIAPNGNILAVRQAVEQISPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N482</accession>
    <name>E8N482_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12120"/>
    <dbReference type="EnsemblBacteria" id="BAJ63246">
        <property type="protein sequence ID" value="BAJ63246"/>
        <property type="gene ID" value="ANT_12120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12120"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629528_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="204"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="435" mass="49155" checksum="CB5FAFE2D3AC216B" modified="2011-04-05" version="1">MKPPNRFFAGLSIEESPEFSSGTITMMKPLGVNVLQGCLWGCLFLLGIVGCTVQPLPTPTPTLNVQETSLFHEAILTATYAIPEPTSTPTTVPSFTPTPTQPPVPPELPRVFQTSLLNPMDHPHPYIQDTCQVLKNRWKMGKSAPGTVVMPIMFHSITDGEVNHPYQISAHQVKELFQALEQKGFEAISMEQLAGFLQSNDYIPPRSVVLIVDDLHSASYYRDHFYPYLHPHGWTVTNAWISEPEASRRVRDENIALQREGWVDHQAHGVVHNINIVEFKPGTTIETSLYGKVDVETFIYRELQGSREAILETFGKAPIAYIWPGGNFSARAVQVAREVGYQLGFTVNPRGPLMYNWIPLGDEIDPKRPALLPENYVQDPLMVLPRYWDKDAILYLDTVIRIGEEARAYALENRERELEYYRLVCEPHVDTTSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F7</accession>
    <name>E8N4F7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_12870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559709.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63321">
        <property type="protein sequence ID" value="BAJ63321"/>
        <property type="gene ID" value="ANT_12870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12870"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="YLGAHHD"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="283" mass="31508" checksum="2AC65FF648832960" modified="2011-04-05" version="1">MSEQTSLQTPSTKTNGQEILRIEGLTKLFGGLKAVNNFSLSLNKGDLNGLIGPNGAGKTTVFNMITGVYVPTAGSIRFNGQEIAGLEPHKINQMGIARTFQNIRLFSNLTVLDNVRIAYHPHAGYSLTDAIFHNARYKENERILTERAQEFLAVFNLQDRQDEIAKNLPYGEQRRLEIARALAAEPKLLLLDEPAAGMNPAETVALMDLIHFIRERFDLTILLIEHQMRVVMGICEYITVMDFGEVIARGTPAEIQANPRVVEAYLGPGSAALSEKFRRKRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4H6</accession>
    <name>E8N4H6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_13060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63340">
        <property type="protein sequence ID" value="BAJ63340"/>
        <property type="gene ID" value="ANT_13060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13060"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1145362_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="26514" checksum="7F6544CC25919DCE" modified="2011-04-05" version="1">MQLSKPWLKLLSVLGIFLIGCVSQPVSQSVPTPAWLYVQVPDSLLSLSDDFQACTPSRGGLALLSPLEPGTPQITLKWGEIQSSNSHAYEIGEEHLLFIVHPDNLIAQVRFEDIQKAYTGKLSSFNWQNLGGSNLPLTLTSYAPESEVTPLLLQLLGISEADLPRELVLVPSPQAMRTFIANTPGGLGILPSRWVDDSVRVLPLEGLNKPQTFPILALSTDEPQGHAYEWLSCLQNRLAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4J4</accession>
    <name>E8N4J4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_13260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13260"/>
    <dbReference type="EnsemblBacteria" id="BAJ63358">
        <property type="protein sequence ID" value="BAJ63358"/>
        <property type="gene ID" value="ANT_13260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13260"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044041_0_0_0"/>
    <dbReference type="OMA" id="KLNRGPN"/>
    <dbReference type="OrthoDB" id="665169at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="452" mass="50138" checksum="598E8C1D170A147D" modified="2011-04-05" version="1">MPNMRKPFFRTFLGILRRELRWLSPGVGLKRWLLLIMLGNTFIGVGIAMLLLDFYRNAPDTWWLPAVSFLALRFLTRPLRVLIFGGIGLGLLLIGLWGFNKTLLSPFIQPGKRVLDSLSEFRKRERGPRIVAIGGGTGLYSLLRGIKAYTHNITAIVTVADDGGSSGELRRTLGILPPGDIRNCLAALANDETLMTHLFQYRFSGSNGLTGHSMGNLFITAMTEITGSFEEAIAESGKVLAVRGRVYPSTLHDVRLAAEVQLPDHAREIHILGESRIPEAKGKIRRVWLEPDNPKAYPPAIQAILNADLILVGPGSLFTSILPNLLVSDIAEALRVSRGLKFFICNVATQRGETDSFTCEDHVKTIEQYIGEGIFDVIICNQNTSKSLPEGIQWVLAGEEFKQSYPVYCTDLIDSESPTRHDPQKLAQAIMEIFEDRTGPLSIRENLNNVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K7</accession>
    <name>E8N4K7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxynucleoside kinase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_13390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559758.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63371">
        <property type="protein sequence ID" value="BAJ63371"/>
        <property type="gene ID" value="ANT_13390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13390"/>
    <dbReference type="eggNOG" id="COG1428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030466_2_1_0"/>
    <dbReference type="OMA" id="RDYETYM"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="4">
        <location>
            <begin position="7"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="212" mass="24683" checksum="834B2314F1547A28" modified="2011-04-05" version="1">MPKRLVLVAGNIGSGKTSLTERIGERLGWITAYESVADNPFLADFYADMKKWAFHLQIYFLGHRAQQHLDMWNDPRSAIIDRSIYEDAFIFARALHHLGNMTEPEYHSYRKVFDLVVAHLPTPSLLIYLKAPVPVLMNRIRKRARNIETGITEEYLALLDSFYEDWLRSFDLCPVLTIRSDDLDFVHRPQHLDLVVQRIQEKLAGKEEMVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L5</accession>
    <name>E8N4L5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytoene dehydrogenase</fullName>
            <ecNumber evidence="6">1.14.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">crtI</name>
        <name evidence="6" type="ordered locus">ANT_13470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 4">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559766.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13470"/>
    <dbReference type="EnsemblBacteria" id="BAJ63379">
        <property type="protein sequence ID" value="BAJ63379"/>
        <property type="gene ID" value="ANT_13470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13470"/>
    <dbReference type="eggNOG" id="COG1233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019722_2_1_0"/>
    <dbReference type="OMA" id="INYPKGG"/>
    <dbReference type="OrthoDB" id="418913at2"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="493" mass="56583" checksum="D66A9762594B2E3C" modified="2011-04-05" version="1">MKVIIIGSGFGGLGAAARLAARGVEVEIFEKRDKPGGRAYVYEINGFKFDGGPTVITAPWMFDEIFTLAGKKREDYVKFVPVNPFYRIFDHEGKQFDYNNDHEFILKEIEKWNPEDKAGYERFIQTTKPIFQKGFVELASEPFLHLQDMLKIVPDLIKLQSYKSVYQYVSQFVKHPFLRTVFSFHPLLVGGNPFEVTSIYAMIHYLEREWGVWYAMGGTGAIVDAMVRLIEELGGKIHLNSEVEEILVSGDRRVNGIRLRDGSVHTADAIISNAEVAWTYRNLIPARYRKVNTNIRYERMRYSMSLFVIYFGTRRRYLDSRLAHHNIILSSRYKGLLDDIFHRKVLADDFSLYLHMPTITDPSMAPEGYESFYVLSPVPHLESDVDWRKVAPVYKDRILQFLEEHYLPDLRANIVAEHYIDPLHFENTLNSFRGAAFSVEPILTQSAWFRPHNQSEDFENLYFVGAGTHPGAGLPGVLSSSIIAEKLILGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N0</accession>
    <name>E8N4N0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.4" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63394">
        <property type="protein sequence ID" value="BAJ63394"/>
        <property type="gene ID" value="ANT_13660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13660"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_0_0"/>
    <dbReference type="OMA" id="AHERYMT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008742">
        <property type="term" value="F:L-ribulose-phosphate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="215" mass="23258" checksum="00B9F31BCE97C0D1" modified="2011-04-05" version="1">MLLPNLREELLYLHLQLPKNGLVTWTSGNVSVRDVSTGWVLIKPSGVFYENLHPEDFILLDLDGNVLEGSLKPSSDTASHLYIYRHRPDVNGIVHTHSPYATAFAAVGKAIPVYLTAQADEFGGAIPCAGLGLIGGEEIGKLVVETIGTSPGCLLQNHGVFTIGKDGSSAVKAAVMIEDIAKTVWLAMQLGTPIPIPEDMVQRLHQRYTRDYGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N1</accession>
    <name>E8N4N1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Ribulokinase</fullName>
            <ecNumber evidence="3 4">2.7.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">araB</name>
        <name evidence="7" type="ordered locus">ANT_13670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17601"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17173"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the ribulokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.16" evidence="3 4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559779.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63395">
        <property type="protein sequence ID" value="BAJ63395"/>
        <property type="gene ID" value="ANT_13670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13670"/>
    <dbReference type="eggNOG" id="COG1069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_9_1_0"/>
    <dbReference type="OMA" id="GHKAMWH"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008741">
        <property type="term" value="F:ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07781">
        <property type="entry name" value="FGGY_RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00520">
        <property type="entry name" value="Ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005929">
        <property type="entry name" value="Ribulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01234">
        <property type="entry name" value="L-ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="6">
        <location>
            <begin position="289"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="558" mass="61974" checksum="92D60BC83E09EC29" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Q8</accession>
    <name>E8N4Q8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13940"/>
    <dbReference type="EnsemblBacteria" id="BAJ63422">
        <property type="protein sequence ID" value="BAJ63422"/>
        <property type="gene ID" value="ANT_13940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13940"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1840964_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="139" mass="15683" checksum="C4DC98F6D6E5B304" modified="2011-04-05" version="1">MANISHELRTPLTHLTGYLDLLLSGDLGPLNPQQRAALEVIQRSSERLAQLIEDLILFSVSEKNQIYLNIRPVNAFELLSSVYQRNSPKAIERQINFHFEPPESTLLVAADQEKVSWVLCCKDRLGRDTPSGVCCRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S8</accession>
    <name>E8N4S8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ordered locus">ANT_14140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559824.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63442">
        <property type="protein sequence ID" value="BAJ63442"/>
        <property type="gene ID" value="ANT_14140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14140"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_1_0_0"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="280" mass="31680" checksum="F3AE037EFF017987" modified="2011-04-05" version="1">MGILYLVATPIGNLEDITLRALRVLREVSLVAAEDTRQTKKLLTHYGIDKPLISYYEHNKLSRLQVILSHLQEGDVALVSDAGTPGLNDPGYELVKSAIEHGFRVYPVPGPASPIAALVGSGLPTDAFLYLGYLPRKQKDRRERIAQIRDEPYTVLFLETPHRLRDSLKDLLDILGNRSAVIARELTKIHEEFLRGTLHDLIQHFDQTEPLGEFVVLVAGASKLEKTWNEEQVLEVFQREFTGNISLKTFAEQLAQVSGWKKNDLYRLFLEQKKNQGTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T0</accession>
    <name>E8N4T0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">tdk</name>
        <name evidence="12" type="ordered locus">ANT_14160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14160"/>
    <dbReference type="EnsemblBacteria" id="BAJ63444">
        <property type="protein sequence ID" value="BAJ63444"/>
        <property type="gene ID" value="ANT_14160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14160"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_3_0_0"/>
    <dbReference type="OMA" id="ENTVNHK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="190" mass="21143" checksum="C24A2C9D6444C40F" modified="2011-04-05" version="1">MKHTTGSIEVITGSMFSGKTDELIRRLRRARIARQKVQVFKPIIDDRYSVEKVTSHAGNEFEAYPISRSEEIWQKLDPEASVVAIDEAQFFDEGIVGVVQALASKGVRVIVAGLDMDFRGEPFGVMPVLMAIAERVDKLQAICMVCGEPASRTQRLVNGKPAKYSDPVVIVGASELYEARCRQHHEVPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z2</accession>
    <name>E8N4Z2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559888.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63506">
        <property type="protein sequence ID" value="BAJ63506"/>
        <property type="gene ID" value="ANT_14780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14780"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_2_0"/>
    <dbReference type="OMA" id="IWGLTAK"/>
    <dbReference type="OrthoDB" id="1623169at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="209" mass="23403" checksum="4FD82F538B684DA7" modified="2011-04-05" version="1">MTLPVKMSLSPEQIARALASPCPLEGMPVCQGKLTQAAVLIPLIRRAESWEVLFTRRTDSVENHKGQVAFPGGAVEEQDRTPEEAALREAWEEIGLPPESVQVLGRLPRLSTITGYCVTPVVGEIVQPVTFHPAPAEVSRVFQVPLVWLADHRNWEWRWYTRLNGTADWVIFYQPYEGETIWGVTAMILHSFLCAIGWMNPAPPPVNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N577</accession>
    <name>E8N577_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559973.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15630"/>
    <dbReference type="EnsemblBacteria" id="BAJ63591">
        <property type="protein sequence ID" value="BAJ63591"/>
        <property type="gene ID" value="ANT_15630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15630"/>
    <dbReference type="eggNOG" id="COG4720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1446925_0_0_0"/>
    <dbReference type="OrthoDB" id="1987601at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="181" mass="19060" checksum="15107A20CD9EE959" modified="2011-04-05" version="1">MKKSLWSFGTREVVFAAIGAALYGVLSYATNILQIPGAGNVAIRPAVALPMFFGVAFGPIVGFISGLLGNVIGDLLSGYGFWPWWDLANGIMGFFPGLVYIGIKNFKDTSDILKAEGMVIVGVLVGIGIAAISELWVSGVDFATTISINFIPSVTTNLVNGLILVPILMVAYSAIQARSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N588</accession>
    <name>E8N588_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15740"/>
    <dbReference type="EnsemblBacteria" id="BAJ63602">
        <property type="protein sequence ID" value="BAJ63602"/>
        <property type="gene ID" value="ANT_15740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15740"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118357_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="34"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="248" mass="29124" checksum="EEE360CD89E4C19B" modified="2011-04-05" version="1">MEFLDRLYQRQSEWTRPLRNFFFRQRFSAPFRVLDAGSGTGVLGNEIAQKYPAEVYSIDLNRDVLAYSRRQRPDISFHAQADIYHLPFPPRFFHCAITHFVFLWLKHPQNALKELIRVTMPGGWIVAFAEPDYEARIDYPGETAKLGQIQKQSLIKRGINPTMGRELFALFNECGLRHVTSGLYSGEWKFPLTHSQFVNEWETLENDLWGYLSFEEIQSYREKDFQNFVKGKRLSFVPTFYAYGQVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B9</accession>
    <name>E8N5B9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative M24B family peptidase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63633">
        <property type="protein sequence ID" value="BAJ63633"/>
        <property type="gene ID" value="ANT_16070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16070"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_1_0"/>
    <dbReference type="OMA" id="IHEWPYL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="148"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="367" mass="40823" checksum="21442F1ED139C8F2" modified="2011-04-05" version="1">MYKKRYEKLQSLMQEHGYDILALNPGPSLFYLTGLSFHLSERPVVLLVPAGSSPTLILPKLEKEKLSQSQIPLQGVFFEDNPETWQNAFNQASELLQLSHKRIGYEAVRLRALEFFLLMKSAPNADFLNAESIIATLRMKKDAEELNRMQKAVEIAQNALLATLPMIKPGKSEKEIASELTAQLLRHGSDPEFPFYPIVSGGPNSANPHATPTERTLRTGDLLVIDWGASFEGYVADLTRTFAIGKIDSELQKIAEVVLRANEEGKRVAHSQIPIGEVDKATRKIITDAGYGEFFTHRTGHGLGLEGHEPPYIFSENNLLIEEGMTFTIEPGIYLPGKGGVRIEDDVVITQEGCYSLSNLSRELVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E0</accession>
    <name>E8N5E0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560034.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16280"/>
    <dbReference type="EnsemblBacteria" id="BAJ63654">
        <property type="protein sequence ID" value="BAJ63654"/>
        <property type="gene ID" value="ANT_16280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16280"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378857_0_0_0"/>
    <dbReference type="OMA" id="HFADGCA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="518"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="731" mass="80969" checksum="BC982A37359837C6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5E7</accession>
    <name>E8N5E7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ordered locus">ANT_16350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560041.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63661">
        <property type="protein sequence ID" value="BAJ63661"/>
        <property type="gene ID" value="ANT_16350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16350"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_0"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="290"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="462"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="613" mass="66951" checksum="95D0728F3A97A6B2" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G9</accession>
    <name>E8N5G9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63683">
        <property type="protein sequence ID" value="BAJ63683"/>
        <property type="gene ID" value="ANT_16570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16570"/>
    <dbReference type="HOGENOM" id="CLU_2857875_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="64" mass="7771" checksum="F1AFD20F724450D7" modified="2011-04-05" version="1">MVIHGILQFLVFFIFYIFYHIKDATNNLILSIFPFTKVTSLFDIYHNSPRFWKCLVRQEEVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H9</accession>
    <name>E8N5H9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560072.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63693">
        <property type="protein sequence ID" value="BAJ63693"/>
        <property type="gene ID" value="ANT_16670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16670"/>
    <dbReference type="eggNOG" id="COG0665">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_4_1_0"/>
    <dbReference type="OMA" id="NDLYPRG"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="9"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="387" mass="42750" checksum="2021E897529217ED" modified="2011-04-05" version="1">MNNASTHYDVIVIGAGSVGTPTALSLAKAGLKVLVLDALPSAGQGSNKHAIGGIRATHSDPAKIRLCLRSIEIFSTWKEIYGDDIEWHKGGYVFVAYREQEERTLKELLRKQQSYGLNISWLDANDLVKLIPYLNREGLIGGTYSPDDGSASPLLSIHAFYKHARQYGAEFHFNEPVMEMIVRGGKIQGVKTTKGTYNAKVVVNAAGAWAKSLGNLVGLTIPVQPDSHEAAITEPVQRLFDPMVVDIRPAKGSANFYFYQHKTGQILFCITPSPNIWGFDTRETSSFLPMVSKRIVEVMPSLQHIRVRRTWRGLYPMTPDGFPIVGWSKEVEGFLLAVGMCGQGYMLGPGLGELLTRMVIQSPLPQDDEILSILSPYREFAGQEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J0</accession>
    <name>E8N5J0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">ANT_16780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560083.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63704">
        <property type="protein sequence ID" value="BAJ63704"/>
        <property type="gene ID" value="ANT_16780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16780"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_0"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="130" mass="13990" checksum="5AF1751E3CB64CF3" modified="2011-04-05" version="1">MNIPAELKYATTDEWVKVEGDVATIGITDYAQDSLSDVVFFEAIVSVGDTIKAKQQIATVESVKAAADINSPVSGEVIAINEALADSPELVNKDPYGTAWMIKVKMSNPSELDNLMDAAGYESYCSGREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U0</accession>
    <name>E8N5U0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560182.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63804">
        <property type="protein sequence ID" value="BAJ63804"/>
        <property type="gene ID" value="ANT_17780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17780"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125323_0_0_0"/>
    <dbReference type="OMA" id="FYTTRKT"/>
    <dbReference type="OrthoDB" id="1776812at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="186" mass="20511" checksum="A3290778E307F798" modified="2011-04-05" version="1">MKELALHLLDIAHNSVSANARNITIEVVEDTRSDLLTLVVKDDGKGMDAQMVQQVVDPFVTSRTTRNVGLGIPLLKAAAEACGGNLEIHSTPGKGTEVIVTFQRSHIDRMPLGNLAETFFTLVVGCPEVHWKFVYQVDDNQYEFDDTLVKQELGDVPLSDPLVLNYLRDELESGIKTLQASFSEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N600</accession>
    <name>E8N600_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560241.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63864">
        <property type="protein sequence ID" value="BAJ63864"/>
        <property type="gene ID" value="ANT_18380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18380"/>
    <dbReference type="eggNOG" id="COG1287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518432_0_0_0"/>
    <dbReference type="OrthoDB" id="1603070at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="525" mass="59486" checksum="1E72CF2C4628A31B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N628</accession>
    <name>E8N628_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560269.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63892">
        <property type="protein sequence ID" value="BAJ63892"/>
        <property type="gene ID" value="ANT_18660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18660"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081003_0_0_0"/>
    <dbReference type="OMA" id="MGLYAEE"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="243" mass="26855" checksum="7CACBDE3BBFF19A6" modified="2011-04-05" version="1">MRNIWIIARKEFKQFFVSPVAYAIALAIFLIMGVLFYATVLSAAYQQYAPSVQVILGPLATIFLFTTPAITMRTLPEEQRTGTLELLLTAPVRDWELVIGKWLGAMGFILTILLVTWVYPIILNRLVDPGIDQGILVSGYLGLVLMVAAFSAIGVAVGSLFSNQIAAFFTTLGVLLVLWMIGYPSMAGGSLGPSLLAYLDISEHFYPTFYRGIIDLKDIVYFISVIALALFLGSISVESRRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N666</accession>
    <name>E8N666_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560306.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63930">
        <property type="protein sequence ID" value="BAJ63930"/>
        <property type="gene ID" value="ANT_19040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19040"/>
    <dbReference type="eggNOG" id="ENOG5031CAS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2299837_0_0_0"/>
    <dbReference type="OMA" id="WDIIPER"/>
    <dbReference type="OrthoDB" id="2023501at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="100" mass="11726" checksum="75B679C204EBD6B8" modified="2011-04-05" version="1">MAYKLIMTWDIIPEREQEYFEFVVREFIPGVQRLGFELTDAWATIYGARPQILVGAMLPTLAKVNKVLQSEEWKRLNSQLLDFVQNYEQKVVEAHGGFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N694</accession>
    <name>E8N694_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tad domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560331.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63958">
        <property type="protein sequence ID" value="BAJ63958"/>
        <property type="gene ID" value="ANT_19320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19320"/>
    <dbReference type="HOGENOM" id="CLU_420161_0_0_0"/>
    <dbReference type="OrthoDB" id="2109322at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tad" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="652" mass="70434" checksum="C2DE6C017DC3B6A8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N698</accession>
    <name>E8N698_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_19360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560335.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19360"/>
    <dbReference type="EnsemblBacteria" id="BAJ63962">
        <property type="protein sequence ID" value="BAJ63962"/>
        <property type="gene ID" value="ANT_19360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19360"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="NYEFFGD"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="239" mass="27598" checksum="E2793CF5F2F533CB" modified="2011-04-05" version="1">MKPKVLIVDDDPTLLRFLQDFLRAEAFEVLAANNGHEALKLAYQEHPDLVVLDVMMPGMDGWEVCSRLHELSDIPIILLTAKTSEQDKLRGFQLGVDDYLTKPFSFAELAARIRAILARAQRSLPAQRKNQITFGEFIMDLDKRELWRGREQMIPLTPTEFRLLEYLARNKGRAVSEQELSEQVWGVYLSSDRSAVRRYIWLLRQKIESDPTHPRWIRTVRGYGYRLGTGTDILPSPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C9</accession>
    <name>E8N6C9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560366.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19670"/>
    <dbReference type="EnsemblBacteria" id="BAJ63993">
        <property type="protein sequence ID" value="BAJ63993"/>
        <property type="gene ID" value="ANT_19670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19670"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026152_3_1_0"/>
    <dbReference type="OMA" id="NKTILFP"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="202"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="392" mass="44458" checksum="BB58549E054C5710" modified="2011-04-05" version="1">MNPIAWIPLLALLFFMGIALQAQWLIYFSATVLLVFGAAHFWTIHALDRVSYRRRFRYRRGFPGEESHVSIEISNQKILPLSWIKTEDPWALQVSPTDEALLAPSPIEGEGWLVNVANLRWFGKINRHFTLRFGKRGIYSIGDTRLYSGDLFGISQRESVLSNREFLTVFPALLPYEMLGLQTEDPFGETQAKNTLFEDPTRFIGIRPYHPEDGFRRIHWAATARSGQLQSKILQPVSARTLAVCLNLSTSEQFWLGYSSPLLEKMISAAATLCYYGIQHRYSVGLYANGCLANADQPFRIQPGETQQHLVHLLEALAGITPYIPQPFEAFLTESLPHIPFGTTLLIITALLSDPLAEMLIRLRTIRRQMVLYKVGEAPHLTLPGIRTIHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF1</accession>
    <name>E8MXF1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20060"/>
    <dbReference type="EnsemblBacteria" id="BAJ64032">
        <property type="protein sequence ID" value="BAJ64032"/>
        <property type="gene ID" value="ANT_20060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20060"/>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314660_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="899"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="929" mass="104157" checksum="209985404DAF1652" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG5</accession>
    <name>E8MXG5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative polysaccharide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_20200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560416.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20200"/>
    <dbReference type="EnsemblBacteria" id="BAJ64046">
        <property type="protein sequence ID" value="BAJ64046"/>
        <property type="gene ID" value="ANT_20200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20200"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_101_4_0"/>
    <dbReference type="OMA" id="TEIMIVD"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="38"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="418" mass="46529" checksum="1F88D1E78C375B54" modified="2011-04-05" version="1">MSELAIHVEHLSKRYRIGKAQKSILHNPSPFRHLAYSMRYYLGAFFQPEETLWALKNVSFEVRQGDVLGVIGRNGSGKSTLLKLLSRVTEPTTGRAIIHGRVGALLEVGTGFHPELTGRENIFLSGAILGMKHAEIQRKFDEIVAFSGVERFIDTPIKYYSSGMRVRLGFAVAAHLEPEVLLIDEVLAVGDAEFQQKCLGKMSEVATAGRTVLFVSHNMAAVQSLCNRGIYLQKGEILVDGTISEAVAKYLKIIDEISQIEISERTDRTGLGNVRLVGVDITDQSHLSALTLITGEPAQFVFHLSHLEPGIKFEYLDFTICDLQGNPVAYFNSIDTGPEDNKSPDMHDRVVCWIDELPLLPGRYRINVGIKANGEMQDHVESAAVFNVEQGRLRGRPIDNRSQRRGSVIFPHRWILPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ8</accession>
    <name>E8MXJ8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560449.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64079">
        <property type="protein sequence ID" value="BAJ64079"/>
        <property type="gene ID" value="ANT_20530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20530"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1146318_0_0_0"/>
    <dbReference type="OMA" id="GHIIRAD"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="251" mass="27662" checksum="6CC8E878F223F3E7" modified="2011-04-05" version="1">MLPIIHLGPLAVQTPGLILLLGVWFALDVTEKHAVRFGISSSKVSRLMLWGVISGILGARIGYALQFPQAFLSSPASLLSLTPQMLSAEAGMLTAFLVSLVYLQKAQLPFWRTLDALTTFFSILAVAIGLSHVASGENFGIPTTLPWAVELWGARRHPTQVYEVILSLGILLVIWIPRKTLSTDSLFEIPGSRFLLFVILTAIVQIVVEPFRASSLWIGPVRQVHFITWLILALALWTLDRRLSQRAKISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX1</accession>
    <name>E8MXX1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64202">
        <property type="protein sequence ID" value="BAJ64202"/>
        <property type="gene ID" value="ANT_21760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21760"/>
    <dbReference type="HOGENOM" id="CLU_1811785_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="142" mass="15924" checksum="C9085711FF51EC8C" modified="2011-04-05" version="1">MSVRKERQAISIEPPVEDLDPAVENALGTPAKRGSIYGRIARVKEMTPAQRRKAEKDRARTKETYDLPAWLIEAVEQIARKYGVPKSNVAAHLLTAGLRDVLEGKINLGWVRKISRSPRYEGLLENPEAIDKSEISRFCSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXX6</accession>
    <name>E8MXX6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21810"/>
    <dbReference type="EnsemblBacteria" id="BAJ64207">
        <property type="protein sequence ID" value="BAJ64207"/>
        <property type="gene ID" value="ANT_21810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21810"/>
    <dbReference type="HOGENOM" id="CLU_810492_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="37055" checksum="5B18878C37A1BAC1" modified="2011-04-05" version="1">MKTMNRSGKAITIVVFVTILLTACSGESVPLDPTAQALYLQRQAEQATQRAEYARMTAQALEAEQVKAEAAARQAEATAEYYRLLRTATMEAVIAEATAISQRETQTAWNATVQAQQTATERAWIVQQTQSALQAQQTAQSWQMTQTAAQSEATATQVALLRQATVDAANAAALATAQAAQAGIAQEALRQEQIRTVQQDYAKYAWAALPFVLLALVVVMSLYGLWLYQRNRVLTQLADGKLVLVQDGKVVVPDRSPGAVLDPRNPPRLDAGQLRVTENDQKVSAIRALVAGGQKGKAERLAQTMAEASSPIPDIRVVAEQDVRPLLGEVVNGIYQEAVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY4</accession>
    <name>E8MXY4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_21890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560585.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21890"/>
    <dbReference type="EnsemblBacteria" id="BAJ64215">
        <property type="protein sequence ID" value="BAJ64215"/>
        <property type="gene ID" value="ANT_21890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21890"/>
    <dbReference type="eggNOG" id="COG1796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1559775_0_0_0"/>
    <dbReference type="OrthoDB" id="2175412at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="19114" checksum="4E7EF0CF8557750F" modified="2011-04-05" version="1">MKAKIPLEIAEQIARQYAERLMPFCDRLEIAGSIRRRKAEVGDIEIVALPKPFVDLFGNENGYQDPMLAGVWVNKAGRRYKQYALPEGVNLDLFIVLPPAQWGVILALRTGGAEFSRKLVTPKPYGYLPQEYVIKDGAVHRADTGEIVPTPEEVDFLTLCGAAHIPPQERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ3</accession>
    <name>E8MXZ3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_21980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21980"/>
    <dbReference type="EnsemblBacteria" id="BAJ64224">
        <property type="protein sequence ID" value="BAJ64224"/>
        <property type="gene ID" value="ANT_21980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21980"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_6_0"/>
    <dbReference type="OMA" id="VHIRMEN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="225"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="304" mass="33599" checksum="CC4BFDFCEC98C65E" modified="2011-04-05" version="1">MRKYRYMRWIRDYKPQPEQQRLYRQALAITLAGNILLASTKALVAYLTGSVAIYSDAANSISDVVYSLMMVFGLWFAQRPPDLSHPQGHSRFEPLVGLFVTASMAYAGFEAARASIERFLAGGLAVRPDLPTFVLLFSAAVKVWMFFLIRNLAKRLASPTLATTAVDHLSDVLTSVAAFVGVLLSSLLHPLADPIAGMAVALWIFRAVLRAARENLGFLTGAGADEELRHKLVEVAESVPGVLRVHHLMSEYTGPQLVVDLHVNVNGQMTLNEAHQIADEVIERLEALPEVDRAYVHVEPEDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY45</accession>
    <name>E8MY45_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_22500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560644.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64276">
        <property type="protein sequence ID" value="BAJ64276"/>
        <property type="gene ID" value="ANT_22500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22500"/>
    <dbReference type="eggNOG" id="COG1550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149981_2_0_0"/>
    <dbReference type="OMA" id="PEEMTYS"/>
    <dbReference type="OrthoDB" id="1813824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="94" mass="10761" checksum="22FF7C19CA3662BA" modified="2011-04-05" version="1">MPVGVLSIHIRLPGCTSLKEKRGRIKPVLARLHREFNVSAAEMDLQDHWQEALLACAALSNDRVQVQRLLQKALEDVHDHFLDIEVLDHHIELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY50</accession>
    <name>E8MY50_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ordered locus">ANT_22550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560649.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64281">
        <property type="protein sequence ID" value="BAJ64281"/>
        <property type="gene ID" value="ANT_22550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22550"/>
    <dbReference type="eggNOG" id="COG2313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012201_0_1_0"/>
    <dbReference type="OMA" id="RKLGHRD"/>
    <dbReference type="OrthoDB" id="1294333at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="305" mass="32012" checksum="349927224C473390" modified="2011-04-05" version="1">MEKIVLSPAVQKALDAKTPLVALETAVVTHGLPYPVNVQLAHALEQEVQEQGATPATIGVLRGAVYVGVSAEALESLAQESAVRKISARDFGIALARGESGGTTVAGTLVVARQVGIRVFATGGIGGVHRHAPFDVSADLFELGRSPLVVVCAGAKAILDLPATREVLETHGVPVVGYQTDEFPAFYSRESGLPVDVRADSPEEVAKIAQTHWQMGNSSAVLVVVPPPVEAALPREQVERWIEQAVQEANQRGIHGAGVTPFLLARMAELSGGTSLQANLALLRQNARVGAQIAGALADFHRCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY67</accession>
    <name>E8MY67_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_22720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22720"/>
    <dbReference type="EnsemblBacteria" id="BAJ64298">
        <property type="protein sequence ID" value="BAJ64298"/>
        <property type="gene ID" value="ANT_22720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22720"/>
    <dbReference type="eggNOG" id="COG1482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675888_0_0_0"/>
    <dbReference type="OMA" id="LCTYEPQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="417" mass="47024" checksum="323F45A92B7D9947" modified="2011-04-05" version="1">MYNHQRLFEGRDILMSTLAEKAFQQGEGILRMAPNWVPRSFCIPGGRLKLHPADLYAFGTHRGGIDERWFASTVKADNGTLTLPDEGLSYVVCGKGDTAEKILFKDVVAELGALLLGEDLWQRFGTFPVFAKFFDNRQALPFHLHHRKEHADLVGQPPKPEAYYFPPQMNNHLGEFPYTFFGLEPGTTPEDIKTCLRRWNSGDNGILDFSRAYRLTLGTGWNIPAGILHAPGSLCTYEPQWASDIYAMFQSLVNDVPFGWDMLTHYVPEERKQDLDFIASLIDWDANTDPQFRRHHLLLPQPVKPVEEMQAEGALQYRVVYGSPLFSSKEVQVLPGRSVILKDEGAYSAVVIQGYGTMGVWEVESPALIRFGQLTNDEFFVSETAARLGVRVENRSASEPLVILQTFGPQPLTSQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY83</accession>
    <name>E8MY83_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560681.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22880"/>
    <dbReference type="EnsemblBacteria" id="BAJ64314">
        <property type="protein sequence ID" value="BAJ64314"/>
        <property type="gene ID" value="ANT_22880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22880"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_0_0_0"/>
    <dbReference type="OMA" id="WGQRKRW"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="47"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="387" mass="44206" checksum="71E7A42FA4C5478B" modified="2011-04-05" version="1">MLDGILRTHQISTLIFAFLVFLIAWLNGVMTRRLEKYPRAKTFPFVSILIPARNEARNLEACLNGLLNQDYPAYEVLVLDDHSSDATPQILAQFSARDSRLRVLQGLDIPDGWLGKHWACHQLAQVAQGEWLLFADADTVFHPQTVSDAVAAVEEEQADFLTAVPHEQMVTLGERLLVPYFLISALSFIPVFLSRWIKLPVFTFTIGQFIFVRAQAYRLIGGHQAVRDNAVDDLALGKRAVAMGLRWRIVDGRNRITCRMYYGFREAWQGFSKNMFAAFGYNVAVYLFIWLWSAVLFLEPLVVLIGAGLGWSSPYFRVDLALLHWMVVLFIWGLAYSRLRMPVGWALLYPVVFLLALIVAGNSFWLTLRGQAEWKGRKVLRPKIRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF3</accession>
    <name>E8MYF3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558496.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00640"/>
    <dbReference type="EnsemblBacteria" id="BAJ62098">
        <property type="protein sequence ID" value="BAJ62098"/>
        <property type="gene ID" value="ANT_00640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00640"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073912_1_0_0"/>
    <dbReference type="OMA" id="FNMLGDT"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="38"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="183" mass="20063" checksum="0358E2D43C9A3B7D" modified="2011-04-05" version="1">MTQRETYPIDIAGVHRELPLFEIKPGLRIAILNILGDTELVTACARALAEKLTAVEYDVLVTAEAKSIPLAHALSVETGKPYVILRKSYKPYMGDALRAETLSITTGQPQTLYLDEKDREMMKGKKVIIVDDVISTGSTLQGMRMLLQKAGAEVVAEAAILTEGERAKWSQIIALGHLPVFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYF8</accession>
    <name>E8MYF8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monogalactosyldiacylglycerol synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_00690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558501.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00690"/>
    <dbReference type="EnsemblBacteria" id="BAJ62103">
        <property type="protein sequence ID" value="BAJ62103"/>
        <property type="gene ID" value="ANT_00690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00690"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028367_3_2_0"/>
    <dbReference type="OMA" id="NIPYMLT"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="221"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="379" mass="42141" checksum="23B6A52B288BC361" modified="2011-04-05" version="1">MIPPLPAEPRRIVFLFSDTGGGHRSAAEAIIEALDVLYEGRIACEMVDFFKQYAPPPMNLAPEIYPPLSRMPALWGMGYRISDGPRRTRVFYSAIWPYVRRHIQQLMAEHPAHLYVSVHQLINTPMARALAGTGIPLVTVVTDMVTTHAAWYARGATHVVVPTEEAFRRGVNAGLSPEQMTVVGMPVALRFQRLNEAREDIRRRLGWNENLPVALMVGGGEGMGPLEEMARAVDEAQLPVTLAIVTGRNQALRMRLERRRWHIPVHVYGFVTEMPAFMRAADILVSKAGPGTISEAFISGLPILLYSKMPGQEDGNVTYVVETGAGLWTPTPEELVSALRRWLEHPEELRRAAEVCRQLARPDAASEIARILARYAGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYG9</accession>
    <name>E8MYG9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_00800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00800"/>
    <dbReference type="EnsemblBacteria" id="BAJ62114">
        <property type="protein sequence ID" value="BAJ62114"/>
        <property type="gene ID" value="ANT_00800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00800"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_0_0_0"/>
    <dbReference type="OMA" id="YLLMTVD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="390" mass="43706" checksum="BEABC1F70DFB3051" modified="2011-04-05" version="1">MNGLPTLSLFEHAPQMAVFFLTLGVFIALSNFFLVRRLGDYPAPNTFPRVSVLVPARNEEANIEACLRSLLTQDYPNYEVLALDDHSTDGTGAILARLAAEFPHLRVLKGEPLPPGWLGKHWACHQLAQAAQGDLLLFTDADTRHAPAMLRRAVAAQVAEDADLLTAFPYEEAHSWGEKLIIPVMGFGIFSFLPVALAQRLGWRGLSVTIGQFMLFRRSAFEAVGGFAAVRAHAVDDVALGRRILEQGFRWRLLDATEEVHCRMYHNLREAVDGFTKNVFAFFDYHVLLYVLAWTWVSICFLEPPLALMGAALNFPLTDFPLPLAQIAVVETLFLWVIAAMRFRFPPLVILFYPLSIALFVMIAVRSLVFTLQGKAEWKGRALSRPALRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK2</accession>
    <name>E8MYK2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23120"/>
    <dbReference type="EnsemblBacteria" id="BAJ64338">
        <property type="protein sequence ID" value="BAJ64338"/>
        <property type="gene ID" value="ANT_23120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23120"/>
    <dbReference type="eggNOG" id="COG3764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905025_0_0_0"/>
    <dbReference type="OMA" id="FRGVGWI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05828">
        <property type="entry name" value="Sortase_D_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041999">
        <property type="entry name" value="Sortase_D_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="33722" checksum="015730A263B38379" modified="2011-04-05" version="1">MPQRVSKGNKVARHRSIDELTVDELRQLLIEKHRRERHKRLEAYRRTGRVIMVEPAPYVSPLEGSSEPLLPEGEAPLPKRKLWIDRILLAIEVLAVIGLALILLNGMNLIRNLNQEVASALVQASPTPTPLISAVVLPSGHTPPNAPGGARFNEEEIPAHLRASVQSLANIPMPTPGPTHAIRIQIPAIKVDAPVVQGDGWEQLKKGVGQHPGTVNPGEKGNIVLSAHNDIYGEIFRDLDRLKPGDEIIISTAQQAFVYVVQQINIVEPTAVEYLASSREPIATLISCYPYMIDNQRIVVIASLQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN8</accession>
    <name>E8MYN8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">ANT_23480</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560740.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23480"/>
    <dbReference type="EnsemblBacteria" id="BAJ64374">
        <property type="protein sequence ID" value="BAJ64374"/>
        <property type="gene ID" value="ANT_23480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23480"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_2_0_0"/>
    <dbReference type="OMA" id="MMATMRC"/>
    <dbReference type="OrthoDB" id="357568at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 11" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_lgN" evidence="13">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="14">
        <location>
            <begin position="111"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="814"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ64374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="868" mass="95721" checksum="48B0136D52B1B35A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN9</accession>
    <name>E8MYN9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_23490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23490"/>
    <dbReference type="EnsemblBacteria" id="BAJ64375">
        <property type="protein sequence ID" value="BAJ64375"/>
        <property type="gene ID" value="ANT_23490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23490"/>
    <dbReference type="HOGENOM" id="CLU_2505545_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="85" mass="9312" checksum="739F524D33E11279" modified="2011-04-05" version="1">MLVWILLGFLILLFVFFLLLASSLLPEETRQSLFTSFQEAQKRITDTTSLMGETIADGIARLGQAVLAIVEAALNSIQFKGDPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYV9</accession>
    <name>E8MYV9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24190"/>
    <dbReference type="EnsemblBacteria" id="BAJ64445">
        <property type="protein sequence ID" value="BAJ64445"/>
        <property type="gene ID" value="ANT_24190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24190"/>
    <dbReference type="HOGENOM" id="CLU_856977_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="312" mass="34717" checksum="678DB6941522DD8C" modified="2011-04-05" version="1">MMTINWRFVFSKFWQITLMGLLIAVGIALFPQAQCAVAQTCDRPSDKWCGTGKCCDFTGGIKYVTRCNGPTYATQPYRCNPSSGNCNVTDWMGWPYETRIYNGRTQAHLPDCVNGVWKENQVWAYVDCCYGSTGGGGCTPSYAPPTIDDTYTVDPPYPVPWRQEQPPYGEALGMTINDIKAHGGADTACGSGQANITSLTVWVELTEESRDWIVYTLGQRYPGAHVLGEYPQYPERPDDPLHPYAHCAWTYGTSGINTPNAELDCRFFRPWDPGDYTVHVTACQSDGKCTTKVLPNPIKVYLLESRLLAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ43</accession>
    <name>E8MZ43_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">recA</name>
        <name evidence="11" type="ordered locus">ANT_01520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62186">
        <property type="protein sequence ID" value="BAJ62186"/>
        <property type="gene ID" value="ANT_01520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01520"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_0"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="52"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="216"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="82"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="362" mass="39054" checksum="827A4152FAC8DDE4" modified="2011-04-05" version="1">MARKSQPPVPIPSRPDPLDEARRAVLDKALGDITKRYGEGAIMRMGEAQHMAVEAIPTGSLSLDIALGVGGVPRGRITEIYGPESSGKTTICQHIVAEAQRMGGVAAYIDMEHALDPAYAARCGVDVENLLISQPDTGEQALEIAETLVRSGAVDVVVIDSVAALVPRAEIEGDMGDASMGMQARLMSQALRKLSGAINQTKTTVIFTNQLRQKIGVMFGNPETTTGGMALKFYASVRLDIRRIQSIKLGAEIIGNRVRVRVVKNKVAPPFRTAEFDIMYNEGISKVGDVLDLATSLDIVTKRGAFFSYGDVRLGQGRENAKEFLRQNPDLLQEIELAVRQRAMSGELPLPLAGGDEDAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ54</accession>
    <name>E8MZ54_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558595.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62197">
        <property type="protein sequence ID" value="BAJ62197"/>
        <property type="gene ID" value="ANT_01630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01630"/>
    <dbReference type="eggNOG" id="ENOG50339SN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129219_0_0_0"/>
    <dbReference type="OMA" id="MRHVQHH"/>
    <dbReference type="OrthoDB" id="1815189at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="158" mass="18550" checksum="798C2B5F41410B3D" modified="2011-04-05" version="1">MNLSAILVSQFLAGLEMLKQTITLCPEDLWNAPQDKNPFWQVTYHALYFVHEYLAESPETFVPWEKHREVYDFDETQTFEPYDQAALLEYLAFLENHVRERLPQLRLDEVEGHGSRSMLTAELQIYSLRHLMVHTGELMERLGARTGANIDWVGWVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ59</accession>
    <name>E8MZ59_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_01680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558600.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01680"/>
    <dbReference type="EnsemblBacteria" id="BAJ62202">
        <property type="protein sequence ID" value="BAJ62202"/>
        <property type="gene ID" value="ANT_01680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01680"/>
    <dbReference type="eggNOG" id="COG3854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022515_2_0_0"/>
    <dbReference type="OMA" id="ILMLGRP"/>
    <dbReference type="OrthoDB" id="452951at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="474"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="538" mass="60056" checksum="9F81ACF48D106B5E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ78</accession>
    <name>E8MZ78_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="4">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aroF</name>
        <name evidence="4" type="ordered locus">ANT_01870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558619.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01870"/>
    <dbReference type="EnsemblBacteria" id="BAJ62221">
        <property type="protein sequence ID" value="BAJ62221"/>
        <property type="gene ID" value="ANT_01870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01870"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_0"/>
    <dbReference type="OMA" id="SMTIQEF"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="2">
        <location>
            <begin position="87"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="358" mass="38838" checksum="E6BF8F078F9A24C1" modified="2011-04-05" version="1">MMIIMRADATQEQISQVVARVEAVGLRAHLSRGQERTLIGAIGDDRTIDKGHFAVLPGVDRVVPILRPYKLASREFSPENTVFPLDGVSIGGNEIVLIAGPCSVESRAQLMEIAHAVREAGAHALRGGAYKPRTSPYAFQGLGEEGLELLAEAREETGLPIVTEVMAPEMVPLVAKYADVLQIGARNMQNFALLHAAGESQRPVLLKRGMSATIEELLMAAEYILSHGNRRVILCERGIRTFENATRNTTDINAIPVVKSLSHLPVILDPSHSTGKWEYVLPIARAAIAAGADGLIVEVHPHPEEALSDGGQSLKPERFVEMVEQVRRIAQAIGRDVAPSPHRERLASPLGAGRRDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC8</accession>
    <name>E8MZC8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRISPR system Cms protein Csm2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CRISPR type III A-associated protein Csm2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_24500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This subunit may be involved in monitoring complementarity of crRNA and target RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated Csm2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560831.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64476">
        <property type="protein sequence ID" value="BAJ64476"/>
        <property type="gene ID" value="ANT_24500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24500"/>
    <dbReference type="eggNOG" id="COG1421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131491_2_2_0"/>
    <dbReference type="OMA" id="VAYHKYF"/>
    <dbReference type="OrthoDB" id="1806103at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09647">
        <property type="entry name" value="Csm2_III-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010149">
        <property type="entry name" value="CRISPR-assoc_prot_Csm2_III-A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03750">
        <property type="entry name" value="Csm2_III-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01870">
        <property type="entry name" value="cas_TM1810_Csm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="136" mass="15380" checksum="01BF1AFA6BD81F4C" modified="2011-04-05" version="1">MSPLSTNDVVQIITRDETAQLLVQRADAFGKELQGMNLSTSQIRSLFGEVRQIQGEWKMGNDARKRALRRLMLLKPKMAYRAKRESGQAVKTLVEALNPAVDAVVTAPSDKQDEYFDRFVQFFEAILAYHKAYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZE5</accession>
    <name>E8MZE5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560848.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64493">
        <property type="protein sequence ID" value="BAJ64493"/>
        <property type="gene ID" value="ANT_24670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24670"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OMA" id="EFAIAWV"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="333" mass="37145" checksum="404A22E006A766AE" modified="2011-04-05" version="1">MEYRMLGRTGVMVSPLCLGAMNFGGPTGEEESIRIIHRALDAGINFIDTANVYNAGMSEMIVGKALKESGRRDSVVLATKVYGKMGEGPNESGVSRLHILKACEDSLRRLQTDHIDLYQLHRPGLNVPVDETLRAFDDLVRSGKVRYIGCSTHPAWMVMEALAVSEKYGLVRYISEQPPYNLLDRRIENELVPLAQKYGLALLPWSPLAGGILSGRYASGEIPSDSRAERMGNMFRERITRRGVEVAQKVAQMAQERGMTPSQLALLWCKDQPGITSPIFGPRTLEHLEELLPVLEMRLNDEDRPLFDALVHPGNAVADFHNSNDWMKARITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZF1</accession>
    <name>E8MZF1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="synonym">ubiE</name>
        <name evidence="5" type="ordered locus">ANT_24730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560854.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64499">
        <property type="protein sequence ID" value="BAJ64499"/>
        <property type="gene ID" value="ANT_24730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24730"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_0_0"/>
    <dbReference type="OMA" id="VRNFENL"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="235" mass="26841" checksum="A8CDDB5DA17720B9" modified="2011-04-05" version="1">MAQHLQGPERAQAVRGMFTRIARQYDLMNRLMTGGMDLLWRKEVIRRAHLRPQSRLLDLGTGTGDLAREALRQEPTCRVTAADFTLEMMRVGKQRYLQPQQWCGADALSLPYPDNTFDAVVSGFLLRNVIHLDTALKEQVRVLRPLGWVVALDTTRPQKKWFSPAIRFYMQRIIPLLGRFIAMAPDAYTYLPETSNAFLSAEELQAHFEQAGLTQTGFRRLNFGTVAIHWGQKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ4</accession>
    <name>E8MZJ4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25160"/>
    <dbReference type="EnsemblBacteria" id="BAJ64542">
        <property type="protein sequence ID" value="BAJ64542"/>
        <property type="gene ID" value="ANT_25160"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25160"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_2_0"/>
    <dbReference type="OMA" id="NIREAKG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="29"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="182"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="430" mass="47431" checksum="826B319149EDFD5E" modified="2011-04-05" version="1">MSLARPEILQTLPGPEDITRVELPNGIVVLVRSNFESASVTLSGYLPAGGLFDPPEKLGLAHFTALGLTRGTERHHFQQIFNLLESAGASLGFGASVYNINFGGRALAEDLPLLLSLLAECLRIPRFPQKPIERLRRQILTGIAIRDQDPADRAEMMFDEVLFPNHPFGKPTDGTRHTIARITREDLLAFHRHYFGPRGMTLVIVGAVSAEQVLEEVQRTLGDWQNPLQPAFPEIPAVAPLAQSVRSHIALPGKVQTELVMGTLGPSRLSPDFMPASLGNNILGQFGLMGRIGNVVREQEGLAYEASTSLNAWKDAGTWEVTAGVNPANLQRAIDLILAEIRRFIAEPVSWEELRDSQSHYLGRLPLSLESNAGVAHAILNLERFQLGLDYYKRYPALVESVTPEQILEVARRWLDPERFAIISAGPPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZP2</accession>
    <name>E8MZP2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64590">
        <property type="protein sequence ID" value="BAJ64590"/>
        <property type="gene ID" value="ANT_25640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25640"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_1_4_0"/>
    <dbReference type="OMA" id="FDYITPK"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="35418" checksum="267FAB163ED0C85D" modified="2011-04-05" version="1">MLQKFEQEHGVKVHYRTYDSLEEAVSVIRAGERVDVANLDVRYIPALKEAGLLLPLRQDRLPNYKNISADFRFLVFDPENHYSIPYNWGITGLLVRIDLLPRPVSRWSDLWDITLTPQVALYRGEKRELAGIALKSLGYSVNTENPVELEQAFQRLAELKQRAVFIEDLGLTSPLELVLEGETPLAMAFAYDWVEAEQQTGEVTMVLPEEGALLWYESFVIPRSCADQDAAELFLNYLMRPEIAAEIADFNHYATPNVAAWELIAPQVRQNPLIFPDNTILERSEMILPLSPQGESFHDELWQRYIDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ0</accession>
    <name>E8MZQ0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sodium ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">natA</name>
        <name evidence="5" type="ordered locus">ANT_25720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560953.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25720"/>
    <dbReference type="EnsemblBacteria" id="BAJ64598">
        <property type="protein sequence ID" value="BAJ64598"/>
        <property type="gene ID" value="ANT_25720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25720"/>
    <dbReference type="eggNOG" id="COG4555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="IQYLNFI"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="244" mass="27071" checksum="BCFB1D45723C459A" modified="2011-04-05" version="1">MIQAEHLKKSFGKVQAVKDVSFTAQDGQITGLLGPNGAGKTTTLRIIYTLLKPDSGTVFVDGVDVVHQPLEAVRRLGALTEAHGLYVRLTARENIRYFGRLRGMEGEALEKRIEELCKLLEMQDFIDRRTEGFSNGQRVKVSIARALLHDPQNVLLDEPTNGLDVMATRAMRTLIRRLRDEGKCVVFSSHIMQEVSLLCDRLVVVAHGEVVLDGTKEEIRQKMGTDNLEDAFVTAIGSAEGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZT0</accession>
    <name>E8MZT0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560983.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26020"/>
    <dbReference type="EnsemblBacteria" id="BAJ64628">
        <property type="protein sequence ID" value="BAJ64628"/>
        <property type="gene ID" value="ANT_26020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26020"/>
    <dbReference type="HOGENOM" id="CLU_996196_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="279" mass="31825" checksum="0D49B77639C10306" modified="2011-04-05" version="1">MKNNELFEYVISTEELAISLALVNRPDLAKATLFEVFGELPNNVLEERLKSSSHSILARGLATIDNNGMPHLSEKFQQALAPLFLFEGMLQMVINRNTPQIINIHLGKEHQFTAHWVEQGVIHHLVFGDLVSILDWITEQSSLPEHLSEELYLLSEKIKGKIPMEIFADLPDKEFSDGVFVLTQYGLDPELAKILLKDIRQPEFRGSVSYLPFHSDQKFESENYFQPVAGVFFLKGKSSWILTFPKEEKKQNGTLLPGTKNEMRVNIQELLLKKDLAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZU4</accession>
    <name>E8MZU4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_02450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558676.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02450"/>
    <dbReference type="EnsemblBacteria" id="BAJ62279">
        <property type="protein sequence ID" value="BAJ62279"/>
        <property type="gene ID" value="ANT_02450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02450"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_0_0"/>
    <dbReference type="OMA" id="IFVKATP"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="344" mass="36288" checksum="58479A08F304CFED" modified="2011-04-05" version="1">MKKSNGLLKIARAVLPYLLAVVAAFAAAGVFIALMGFDVFKAYGTILFTSFRTPNGFVQTLLKFVPLVLQALAFTIPLTAGKFNIGGEGQLLVGATAATVAGIVFAQLPPILLVPLVLLAGVLGGALWGLIPGWLLYRFGINEILTTVLLNFVSFNLVNYVCTGPLRDPAAGHPTTIAIGQNGWLPMLINNPPLHSGILLAILVVAVVYYAITRTVSGYELVATGANPRAAGVFGINTRWMFIASLVIAGGVGGLSGALEVAGVQHRLIEGMQHNFLVLGLIIGLIAKGNNLAVPFVAFFISVLEVGASAMQRTLMIPVEMVFIVEALILVFVLLSDLVQKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZV4</accession>
    <name>E8MZV4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558686.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02550"/>
    <dbReference type="EnsemblBacteria" id="BAJ62289">
        <property type="protein sequence ID" value="BAJ62289"/>
        <property type="gene ID" value="ANT_02550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02550"/>
    <dbReference type="HOGENOM" id="CLU_1902316_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="133" mass="15250" checksum="DDFF3639C889178D" modified="2011-04-05" version="1">MSDWFLRAFRKTPPRDFRQQLYAHLEAEERRLALLWRSTAAVLLILIALSPTFLNAPSRSAFVPSRTSPSQAESTITSTVPEWEQELPAGWVYYPPGEIEAFGPMDYRAEQKRRASPPETPMFIAMVIPGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX5</accession>
    <name>E8MZX5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558707.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02760"/>
    <dbReference type="EnsemblBacteria" id="BAJ62310">
        <property type="protein sequence ID" value="BAJ62310"/>
        <property type="gene ID" value="ANT_02760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02760"/>
    <dbReference type="eggNOG" id="COG3173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083624_1_0_0"/>
    <dbReference type="OMA" id="GDRLCHG"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="37"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="264" mass="29789" checksum="877769626AD4AFD5" modified="2011-04-05" version="1">MDDLDKPIAYGRTAEIFAWGENQVLKLFHAWVGFDAVEYEYRIARTMQSCGLPVPQVGEIIEYKGRYGITCQRIKGISMTESLARAPWKILRYARRMAELHARVHAVTHPTDIPPLNPKMARKILQAQSLPARLREKALTRLEKLPEGHDLCHGDFHPDNILLTPQGEVILDWMDAGTGNPLADLARTSIILKGSIESGQIRHPLLKRLAHLFHRAYLAQYFSLRPGGESEYALWLPIIAAARLSENISELEGWLVAQAERGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZX8</accession>
    <name>E8MZX8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_02790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558710.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02790"/>
    <dbReference type="EnsemblBacteria" id="BAJ62313">
        <property type="protein sequence ID" value="BAJ62313"/>
        <property type="gene ID" value="ANT_02790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02790"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_0"/>
    <dbReference type="OMA" id="DMATPNT"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228008" evidence="2">
        <location>
            <begin position="27"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="5">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="171"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="371"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="731" mass="79763" checksum="B9B6BC135A2189A6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY8</accession>
    <name>E8MZY8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558720.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02890"/>
    <dbReference type="EnsemblBacteria" id="BAJ62323">
        <property type="protein sequence ID" value="BAJ62323"/>
        <property type="gene ID" value="ANT_02890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02890"/>
    <dbReference type="eggNOG" id="COG1738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075503_1_2_0"/>
    <dbReference type="OMA" id="IFQKFFY"/>
    <dbReference type="OrthoDB" id="1462872at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="26914" checksum="A6A9E5F2C4C4AB16" modified="2011-04-05" version="1">MSVSQNEERSYRYLDLVMALFVTVLIVSNIASSAKIVDWGLSIGNIPLAFDAGTLLFPISYIFGDVLTEVYGFRRSRRVIWTGFAMLALSAFIFWVVRNLPGEATWQEYAGQSAYDAILGGMFSGGIVLASLIAYLAGEFSNSIVLARMKVLTQGRFLWMRTIGSTLVGEGVDTLVFILVASLTGVFPWSLFGTLMLTNYLFKVGVEVVMTPLTYQIVNALKRAEREDYYDVHTRFTPFALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N006</accession>
    <name>E8N006_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03070"/>
    <dbReference type="EnsemblBacteria" id="BAJ62341">
        <property type="protein sequence ID" value="BAJ62341"/>
        <property type="gene ID" value="ANT_03070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03070"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_552810_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="493" mass="51032" checksum="217F24A23707371F" modified="2011-04-05" version="1">MGKSNAHPHSMGSTQKNWRCEMKQSFNFLGMLATILALALTAGLTQAQANPAQLQAAIGDGFTYQGMLNKGGNPYSGVCDFQFSLWNASNDGTQIGTTQEKTSVQVTNGIFTISNLDFGAYAFPGDERWLEIAVKCTGDAGFTTLTPRQPLTAVPYALYSKNSWSTSGNKGTVPGTHFLGTTDFQPLELRVNNQRALLIQPKTSSTLNIIAGHAANTISSNVVGATIAGGGGNDVWKNEIKSSGDFATISGGKINTADGNGATISGGTANTANGQAVVIGGGNINTAVGYAATVSGGGNNQALKDGDTVGGGMNNTANGSNSVISGGAYNTTTAVMAAIPGGYRAKADHFGQMAFASGSFSTTGDAQTSTFVMRNSSTGSSSITLYLDGTSALLTIADGRTLTFDILIAGRSNTGESAGYHIQGIIENVDKSLSFIGTPTITILGEDDPAWNVRVIADDVNDTLNIQCKGNDEVVRWVATVRTAEVFWGSDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8N052</accession>
    <name>E8N052_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">gyrA</name>
        <name evidence="11" type="ordered locus">ANT_03530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558784.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62387">
        <property type="protein sequence ID" value="BAJ62387"/>
        <property type="gene ID" value="ANT_03530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03530"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_0"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="9"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="528"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="814" mass="90207" checksum="E783D07AB3109702" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N087</accession>
    <name>E8N087_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560990.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26100"/>
    <dbReference type="EnsemblBacteria" id="BAJ64636">
        <property type="protein sequence ID" value="BAJ64636"/>
        <property type="gene ID" value="ANT_26100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26100"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_0_0"/>
    <dbReference type="OMA" id="LWVRAFA"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="346" mass="39210" checksum="4EFD28FF4DFD5A77" modified="2011-04-05" version="1">MSHPPVLLVGNFLSRHGLGRAVGEDLSEHLHARGWQVITTSHQRSRALRLADMLTTALKQRNQYRLALVEVYSGAAFRWAEAVCLILRWLKKPYILWLHGGNLPHFAQKCSGRVSRLLRHAHAVVAPSAYLQEHMRLYRQDILLIPNPLEIRRYPFRLRRDLRPSLVWLRAFHAIYRPAMAVEVLRRVKEWAPDVHLTMYGPEKGDGSLQEVRRTAQRYGLEGALSLPGRVPKEEVPQVLQQGDIFLNTAGVDNTPVSVMEAMACGLCVVSTRVGGTPYLLQHEQDALLVPPADADAMAEAVLRLLREPDLAERLSCSARRKAEAFDWSVVLPQWEKLFDEVFAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0A7</accession>
    <name>E8N0A7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoamylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561010.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26300"/>
    <dbReference type="EnsemblBacteria" id="BAJ64656">
        <property type="protein sequence ID" value="BAJ64656"/>
        <property type="gene ID" value="ANT_26300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26300"/>
    <dbReference type="eggNOG" id="COG5368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023287_0_1_0"/>
    <dbReference type="OMA" id="CLITYVM"/>
    <dbReference type="OrthoDB" id="1384939at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019282">
        <property type="entry name" value="Glycoamylase-like_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10091">
        <property type="entry name" value="Glycoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoamylase-like" evidence="1">
        <location>
            <begin position="180"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="418" mass="47713" checksum="C0480BED5BAC7948" modified="2011-04-05" version="1">MKAQQIIEQELNRSIDFFLETTNLNPASRGFGLALDSTKDPHTSSIASVGFALTGWVIAYERNRLTRTRALEITRGTLRTLLENVPHHRGFFAHFLNMETAERLHQCEYSTIDTAICLNGVVTAAAYFQDAEIQQVAQELLNRVDWDFIVFEKEGKALFRMAYNPDRDGDYVHGDPGFIHQWDMAAEQKMMYLLAAPYLTPETARALYAGFNRDMGEFQGKPVIINPGGNLFCYQLSEAWLDVRTYLDPDGVDWFENTRLATLADRAFCMQHALRYRTYHANSWGLNAGDSPFGYRVYGSAPSLYEPEHDGTVSIAGALASLPFAPEEVLSMAEYLYHQHPQTWGRYGFFDAYNLDVLPPWYGKDIYGFNKGLSMIMIENYLSGLIWDVYTHSPLIQSALEILRFVPRREVEHGTIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0A8</accession>
    <name>E8N0A8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561011.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64657">
        <property type="protein sequence ID" value="BAJ64657"/>
        <property type="gene ID" value="ANT_26310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26310"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_2_0"/>
    <dbReference type="OMA" id="HERVERY"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="351" mass="39192" checksum="FED780DAB29C4F2F" modified="2011-04-05" version="1">MAKKDGVTIKDVARHAGVSIAAASYALNDTGTISDATRQRVLKAAEELNYHPNAFARHLKKRKTHTIGVFITGFGGLFFEQILDGIHAVAVETQYDLIVCPSSRAVSKILTQRQVDGAIVFDTRIPNETLTRLASQRFPIVALDRFLKVDYFFPLLMDNVNGVRQVMAHLVEQGARRVNFVSGAGDSFDNRERMLTFMEEADKHGVQYRVYQGDFNEKSGYQAGLEMIQAQDVPDAVFCANDQMAIGLMRAFQEHGLRIPEDVGLVGFDDIVVAPLLTPPLSSVNMSRYQWGIRAARQLIDFLEEGKPITCQRMPTRLVVRRSSLISPSSRLKQEHHESTADHRTGTESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0D6</accession>
    <name>E8N0D6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SHOCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561038.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64685">
        <property type="protein sequence ID" value="BAJ64685"/>
        <property type="gene ID" value="ANT_26590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26590"/>
    <dbReference type="HOGENOM" id="CLU_159099_0_1_0"/>
    <dbReference type="OrthoDB" id="2068436at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHOCT" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="72" mass="8213" checksum="41B0AA8894D6716E" modified="2011-04-05" version="1">MMGFGMIGGMILFWGLLILLAVLLIKGLFHSNQTVGNNRSSTTLSPREILEQRYARGEITREQFLQMQKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E4</accession>
    <name>E8N0E4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">groEL</name>
        <name evidence="6" type="synonym">groL</name>
        <name evidence="9" type="ordered locus">ANT_26670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561045.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64693">
        <property type="protein sequence ID" value="BAJ64693"/>
        <property type="gene ID" value="ANT_26670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26670"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_0"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="543" mass="58312" checksum="638928446057FE33" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F7</accession>
    <name>E8N0F7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561058.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26800"/>
    <dbReference type="EnsemblBacteria" id="BAJ64706">
        <property type="protein sequence ID" value="BAJ64706"/>
        <property type="gene ID" value="ANT_26800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26800"/>
    <dbReference type="HOGENOM" id="CLU_1493246_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225189" evidence="1">
        <location>
            <begin position="26"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="180" mass="19046" checksum="6246E330E9E2BF24" modified="2011-04-05" version="1">MKIFSVWLILVFTAGALSACQPASTATPTPNLDATIAAGVATQLAKMQPTQDIPATVSAQQTQFAQALPTQAPTQPSPAMTPTLSDEEALRLALLAYLGWQENELIFSIGQIQNNLARGGVKRAGEEQGAGWFAGKQTDGTWVIVHVGQGIPYCADIAAFSFPTDWISHCMDASGNAVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I9</accession>
    <name>E8N0I9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPDK_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561090.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27120"/>
    <dbReference type="EnsemblBacteria" id="BAJ64738">
        <property type="protein sequence ID" value="BAJ64738"/>
        <property type="gene ID" value="ANT_27120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27120"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015408_0_0_0"/>
    <dbReference type="OMA" id="GDNVVWQ"/>
    <dbReference type="OrthoDB" id="90546at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPDK_N" evidence="1">
        <location>
            <begin position="198"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="777" mass="89744" checksum="003EB262FD0B88C3" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0M5</accession>
    <name>E8N0M5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="11" type="ordered locus">ANT_03860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558816.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03860"/>
    <dbReference type="EnsemblBacteria" id="BAJ62420">
        <property type="protein sequence ID" value="BAJ62420"/>
        <property type="gene ID" value="ANT_03860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03860"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_0"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="145"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="379"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="444" mass="49481" checksum="DE39F69B13A22897" modified="2011-04-05" version="1">MSKRFYLVSLGCAKNTVDSQSMASLLQEAGFEPTDRQKEADVLIVNTCGFIGPARQESLDTLRDLARHKKKHQLLVAAGCLTERYRQQVAQEVPGIDGILGTRRWMDIVDLVQQLRPGRKYPEPLYHLPETPTVGKDEKGVLRAAIQGASAYLKIADGCRRPCAFCAIPLIKGTAVSRPPEVILQEARILQDEGVKELLLIAQDTTDYGHDLGMKDGLATLLEGILREAPEIPWIRILYAYPGYVTDRLIEVMANHPQIVPYLDMPLQHAHPQTLRRMRRPSNMEWVYQTLAKMRAAIPNLALRTTFIVGYPGETEEEFQTLLDFVQEIQFDHVGIFTFSFEKGTASEPLGDPIPAEVKQERLARLAEVQERVSLARNQSYVGQIQPVLIEGFDRGIAIGRAPHDAPEIDGLVFVEGEAPVGEIVPVRITGAMTHDLTGVLVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S0</accession>
    <name>E8N0S0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NarL family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_04310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558861.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04310"/>
    <dbReference type="EnsemblBacteria" id="BAJ62465">
        <property type="protein sequence ID" value="BAJ62465"/>
        <property type="gene ID" value="ANT_04310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04310"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_0"/>
    <dbReference type="OMA" id="LDRFAPM"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="214" mass="23534" checksum="0174069464C2274C" modified="2011-04-05" version="1">MSGKYRLVVVDDHALFRRGLISLLEEMPEFDVVGEASDGEEALKVIAQRHPDIALVDVNMPRMDGIALVQALRRQKSALKVLMLTISQEDQDLIGAIRAGANGYILKNTEPEDLRKALLNIAEGKGVLSPEVVPPVLGVMQRGTLDSSPQLLSDRELEVLQCLAEGLTTQQIASRLFISENTVKTHIRHILDKLEASNRTEAVGKATQLGILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0T7</accession>
    <name>E8N0T7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_04480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558878.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04480"/>
    <dbReference type="EnsemblBacteria" id="BAJ62482">
        <property type="protein sequence ID" value="BAJ62482"/>
        <property type="gene ID" value="ANT_04480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04480"/>
    <dbReference type="HOGENOM" id="CLU_159961_1_0_0"/>
    <dbReference type="OrthoDB" id="1736917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="106" mass="12631" checksum="F3774590C695E1C4" modified="2011-04-05" version="1">MIIQVERTGGFAGLTMQAIIDTEHLDPEEREELEELVEKSEFFRLPPRLKVQTMAVNQFEYVITIEDEFQRHTLEAHEEALDPRLNELVQRVLRLARRKQREKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V1</accession>
    <name>E8N0V1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558892.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04620"/>
    <dbReference type="EnsemblBacteria" id="BAJ62496">
        <property type="protein sequence ID" value="BAJ62496"/>
        <property type="gene ID" value="ANT_04620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04620"/>
    <dbReference type="eggNOG" id="COG3743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1933642_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="130" mass="14088" checksum="DE008E59686A6E49" modified="2011-04-05" version="1">MHQRRGGVAWWLAFPLMGLLAGLFALLLLERRKRVHQQGPAVSPPAPSIVLPPEEDAPLPADDLTVIRGIGPKTAVVLAQAGIRTFAHLVQSSPDSLREVLSQSALRLPNASPEDWIAQAKARLERQTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N104</accession>
    <name>E8N104_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558945.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62549">
        <property type="protein sequence ID" value="BAJ62549"/>
        <property type="gene ID" value="ANT_05150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05150"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718951_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="384" mass="43092" checksum="283E53232CE546BC" modified="2011-04-05" version="1">MRPKSLPWLVFLCVRVPLLLALSFDGLRGYGDFFHFYRLAQFPGLPFVNYWVEFPPLFPFLIEGLARLAPRENAFTYLLVLLLTLADLGNVLLFQRLSQRLNLPDDSTRTILYAALIAGLAYTWWYFDSVCVFFTLLGLDAMLTGRSAGKTGLAIGLGMLTKWFPALLLPALWRILPPKRAVLATLTAFGLVLVVYAGLWTASPAFTNASLRSQSAKGSWETVWALLDGNWGTGNFGELSQRSDPQAAAQTMGNPARIPAWLSLLALGGLGLFLYWRYKVTSPQDALPLIGLTWGLFFLWSPGWSPQWVLYLIPLILLSLPLRQALLMGGALMLVNLLEWPLLLSRGWFHLLPLSVILRTFLLILLVMVWAQNPLKLLQPDFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N121</accession>
    <name>E8N121_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05320"/>
    <dbReference type="EnsemblBacteria" id="BAJ62566">
        <property type="protein sequence ID" value="BAJ62566"/>
        <property type="gene ID" value="ANT_05320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05320"/>
    <dbReference type="HOGENOM" id="CLU_1025439_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225377" evidence="2">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="271" mass="29856" checksum="141E511AF46C3D6F" modified="2011-04-05" version="1">MKFLSAFLLLILTGLSACRTVLQPMPSPTQTSLTVTPTFPSVPEPSATSPSESVTCDMLKDASSGLKGVLECSQQDGMIWVSLNVPYSDALGDFYRWSEGEGWKPVEGAVEGSVFQKGNTLLAVYNPEPSLEDPQRKTELPTGTRGRMALGVFSALPESAGRSLFPGPPDCQNLPPLFFPPESILKCRQQAHAVFLYTPYESRAILLILYALLKQADWQVSTWDWALQRTVWKKGESNLFLEALFPNATAVQGDTFPPLARSRLEWRVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N145</accession>
    <name>E8N145_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27620"/>
    <dbReference type="EnsemblBacteria" id="BAJ64788">
        <property type="protein sequence ID" value="BAJ64788"/>
        <property type="gene ID" value="ANT_27620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27620"/>
    <dbReference type="eggNOG" id="COG2210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094970_1_0_0"/>
    <dbReference type="OMA" id="LQACQMT"/>
    <dbReference type="OrthoDB" id="2045228at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="168" mass="18317" checksum="931111CC8E563B33" modified="2011-04-05" version="1">MSMAEETRKIAFICSKGDLDMAYPALVMGWAALGNGIDVTIFFTFWGLDLINKHRVDHLELAPVANTSMKMSMMGIPGNLGIPNLVGVLPGMTALTTKLMKDKMKALGVPPVREYLEMLVDGGAKLYACKMSVDMMGLKKEDFIDGVEDIVTAGDFMDMTEGAQIIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N173</accession>
    <name>E8N173_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_27900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27900"/>
    <dbReference type="EnsemblBacteria" id="BAJ64816">
        <property type="protein sequence ID" value="BAJ64816"/>
        <property type="gene ID" value="ANT_27900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27900"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_2_0"/>
    <dbReference type="OMA" id="MFNFIAA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="45525" checksum="68D6C16DD7D0F897" modified="2011-04-05" version="1">MSENKPKQDAGKVFLEEVTGQSEEAQRLKGWRKTGRTLVVPLLAIFTGLVFGAIFIVVTSEDVYAAFRVSFGTGMAAVWKTIIQSYQALFTGALGDPARIVAAFQSGNPLEIRRAVNPILESLVNATPYIFAGLAVALGFRSGLFNIGVEGQLFMGAAAATAVGIFVKGLPQIIHAPLAFLAGALGGALWGFIPGWLKAKTGAHEVINTIMMNWIAFRLTEWLLSGPLTRPGSGGLPISPIIEKSAEIPQFFPPPIRFHLGFFIALAFAYAVHWLLFKTTWGFDLRTVGANPNAAKYAGMNITKNIVLAMTLSGALAGMAGANQILAVNRSMALGLSPGYGFDSIALALLGNSTPMGVVLASLLFGALRNGATRMELLYIPNDIISIIQALILAFVAAPAIIRTIYRIRVPKEAEEAVFTGSWGGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N197</accession>
    <name>E8N197_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">metK</name>
        <name evidence="17" type="ordered locus">ANT_28140</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28140"/>
    <dbReference type="EnsemblBacteria" id="BAJ64840">
        <property type="protein sequence ID" value="BAJ64840"/>
        <property type="gene ID" value="ANT_28140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28140"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_0"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="133"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="251"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="BAJ64840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="403" mass="44007" checksum="73A1811132024423" modified="2011-04-05" version="1">MSLTFMNMPRYLFTSESVTEGHPDKICDQISDAVLDACLEQDPYSRVACETATKTGFIMVLGEITTKAFVNFDELVRKVLLEIGYDNTDKGFDGNTCAVLSAIANQSGDIAMGVDKALEAKSGEMTEAEIEAIGAGDQGMMFGYACDETPTLMPTPIYYAHKLTRRLAEVRKNGTLPWLRPDGKSQVTVEYHYGKPVRVDTVLISTQHAPEVSHSEIREAVLEHVILPTLPENMVDDHMKVFVNPTGRFVIGGPMGDAGVTGRKIIVDTYGGMGRHGGGAFSGKDPTKVDRSGAYAARWVAKNVVAAGLASRCEVQVAYAIGVARPLSINVETFGTGKIPDEKIAQLISETFDLRPGAIIRDLDLRRPIYRKVAAYGHFGRDDLDLTWERTDKAEILRRAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I4</accession>
    <name>E8N1I4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558985.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05550"/>
    <dbReference type="EnsemblBacteria" id="BAJ62589">
        <property type="protein sequence ID" value="BAJ62589"/>
        <property type="gene ID" value="ANT_05550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05550"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609228_0_0_0"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="449" mass="48818" checksum="6803824E53E75A69" modified="2011-04-05" version="1">MSAGLSYKRSSSQPHRLKPFRRAVVLLLSALLFLSGCLPPWLASPTPTASPPLPTATPPVSPTPSTEALATPTVSEPLVLWLPPQFDPESGSRAGNLLKERLAAFEQENGIQIRVRLKAVNGPAGLLDSLTLASAAAPAALPSAVLLPRRDLEDAALKGIIYPLDGLSTAIDTSDWYDYARELALVQGSVYGLPMAGDSLGLVYRSEWLAHSPNSWQEILEQRYTFTFPAQENQSLVTLALYLSAGGDTQDTQRRPLLEETPLQTVFTWYRSAAERAVIPIWTAQVETYSQAWQAYQDQRTTMVVAWVSTYLSDFPPDSLFAPLPSLGDAPASLATGWVLAVAEPDPQRRVLAARLCEWLTQSDFLGAWSEAAGVLPVRPSAFPLWKNQSFVPVFQRMAETARPIPSNEVITVLGPVLRESTLEVLQLKTLPASATQDAVKKVANPGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N0</accession>
    <name>E8N1N0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na(+)/H(+) antiporter subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mrpC</name>
        <name evidence="6" type="ordered locus">ANT_06010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559030.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62635">
        <property type="protein sequence ID" value="BAJ62635"/>
        <property type="gene ID" value="ANT_06010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06010"/>
    <dbReference type="eggNOG" id="COG1006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082058_3_1_0"/>
    <dbReference type="OMA" id="YRVYEEH"/>
    <dbReference type="OrthoDB" id="2078994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="125" mass="13289" checksum="047EE04A3AF2122E" modified="2011-04-05" version="1">MNVLLAITAGVLFGGGLFMMLRRSLVRVLIGLLMISNAVNLIIFTAGRLVPAHPPLISPGNNALTPPYADPVPQALILTAIVISFGVAAFAIVLMQQTYRALGNADMNDMRSTDTPVEDEEEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Q0</accession>
    <name>E8N1Q0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_06210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559050.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06210"/>
    <dbReference type="EnsemblBacteria" id="BAJ62655">
        <property type="protein sequence ID" value="BAJ62655"/>
        <property type="gene ID" value="ANT_06210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06210"/>
    <dbReference type="eggNOG" id="COG2720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011572_1_0_0"/>
    <dbReference type="OMA" id="FYIERYP"/>
    <dbReference type="OrthoDB" id="967747at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="539"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="619" mass="68094" checksum="BD15638DF72BFDBB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1T1</accession>
    <name>E8N1T1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_06520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62686">
        <property type="protein sequence ID" value="BAJ62686"/>
        <property type="gene ID" value="ANT_06520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06520"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="258" mass="27299" checksum="3FA8452FC3E5B937" modified="2011-04-05" version="1">MSFEKTHEPRYMLITGAAGGIGRATVKVFAEAGWVVIGVDRRPFGEDFPQNGLFIQADIADPEALRGIYDQAAAFTHTLDAVINNAAIQIAKPLLETTAEEWDLVMASNLRSVFLGAKLGYPLLKAGGGGAIVNVSSVHAIATSANISSYAASKGGLLALTRAMAIEFAPDNIRVNAILPGAVDTPMLRMSMQRGSLTGSDVLDRLENLARKTVNGRVAQPEEIARCIYFLADSTQSSFMTGQALVVDGGATARLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Y2</accession>
    <name>E8N1Y2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561274.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64929">
        <property type="protein sequence ID" value="BAJ64929"/>
        <property type="gene ID" value="ANT_29030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29030"/>
    <dbReference type="eggNOG" id="ENOG50334K0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2407910_0_0_0"/>
    <dbReference type="OMA" id="TCSHIMA"/>
    <dbReference type="OrthoDB" id="1828010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="75" mass="8822" checksum="400C289F452AD016" modified="2011-04-05" version="1">MDYGMIGKIEKAKRYAQQRERFHFKSFTVTMDGENNSHTIEYADGQWKCDCDFFQTRGRCSHTMALEMILEGMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N200</accession>
    <name>E8N200_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_29210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64947">
        <property type="protein sequence ID" value="BAJ64947"/>
        <property type="gene ID" value="ANT_29210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29210"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620700_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="484" mass="53826" checksum="3D80A041557AE7DD" modified="2011-04-05" version="1">MYRLSVEALWALMALALPFTSFPLVARLTGSSMVAPAALFPLAALVVLWFPPQLWQGARLPRLVLPLLAFAGAGVLSTLLSYFLPLPAFRDIAPYRQQIEALATLGMGMAFYLLTTLWTSEPERRRSFLRWVNLSGVILITAALAQALFWKLHGAYPQWMDALQSLLVTHELYPARASALAFEPSWLAHQLNMLYLPWWLAASLRGETVHRWRWGFLTAERLLLLGGLASLVVSVSRVGLLALVLMMAFLLIGVALRLMARLQDRLTRRSRAQGFARIFLRATVGAALILAVGALVLSMFIGSALALRRFDPRMEKLLDFRVLLVKGSFLAYANQLVFAERLIFWQAGWQVFNEHPLLGVGMGNAGYFFPQTLSAFSWNLTEVSTLMYRLSVIPNSKSLWVRLLAETGALGFACWLVWLMVQGWTACRLFRSSGRFSGTIGLTGLLLLAGLIAEGFSVDTFGLPYYWMTLALVAGASMDKGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N248</accession>
    <name>E8N248_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_29690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561339.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29690"/>
    <dbReference type="EnsemblBacteria" id="BAJ64995">
        <property type="protein sequence ID" value="BAJ64995"/>
        <property type="gene ID" value="ANT_29690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29690"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="OMA" id="ARVIVME"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="349" mass="38321" checksum="677077DAA6184418" modified="2011-04-05" version="1">MIALSLHHVSRTFAQNPRPAVDDLSLDLPAGQILALVGPSGCGKTTTLRLIAGLECPDRGKIFINGRLMASSLVFVPPERRGVGMVFQDHALFPHLTVFDNVAFGLRGKPRTQVRQTVHAMLEMVGLQALAGRYPHALSGGERQRVALARALAPRPVLVLMDEPFSSLDADMRLEMREQVRGILKEMGATVVFVTHDQEEALFMGDRLAVFREGRMEQLGTPEEIFHASTSRFVAEFMGDSDFLPGSVVHEGIHTPLGVIAQPLSLPAGTPVEIALRADDVDFVPDGQNGNAVIVERFFRGAFHVYRLRLESGEVLHAFKEHTLVLPAGMRVRARISAEHPLIVFPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N252</accession>
    <name>E8N252_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561343.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64999">
        <property type="protein sequence ID" value="BAJ64999"/>
        <property type="gene ID" value="ANT_29730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29730"/>
    <dbReference type="HOGENOM" id="CLU_1755054_0_0_0"/>
    <dbReference type="OrthoDB" id="1776755at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="148" mass="16388" checksum="66F156C136929482" modified="2011-04-05" version="1">MSKMVRWALILLVLLPLMGCRISLLHLNEDKDTLTFVVRADSDWQDTGIQVKPGMRVRIRQVSGLWSPWSGSTYDAVGSGGDPHCDCNVAEGISHAALIGKVGNSQPFYVGRDFDQHLGERGTLYLRINDTHLQDNAGALEVVIEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N266</accession>
    <name>E8N266_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561357.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29870"/>
    <dbReference type="EnsemblBacteria" id="BAJ65013">
        <property type="protein sequence ID" value="BAJ65013"/>
        <property type="gene ID" value="ANT_29870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29870"/>
    <dbReference type="HOGENOM" id="CLU_2713555_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="72" mass="8156" checksum="3339FA4F018A008C" modified="2011-04-05" version="1">MDARDLLILGLITGMTMMALLALEFLRRRALRWEAHLFLGLLAIFLPVAGPFLAILLAPGFFIPSRQVHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N277</accession>
    <name>E8N277_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_29980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561368.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29980"/>
    <dbReference type="EnsemblBacteria" id="BAJ65024">
        <property type="protein sequence ID" value="BAJ65024"/>
        <property type="gene ID" value="ANT_29980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29980"/>
    <dbReference type="HOGENOM" id="CLU_453205_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="602" mass="69992" checksum="B615E02965CB5FC1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2F8</accession>
    <name>E8N2F8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559157.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07300"/>
    <dbReference type="EnsemblBacteria" id="BAJ62764">
        <property type="protein sequence ID" value="BAJ62764"/>
        <property type="gene ID" value="ANT_07300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07300"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047712_0_0_0"/>
    <dbReference type="OMA" id="YKFYWFL"/>
    <dbReference type="OrthoDB" id="1105453at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13395">
        <property type="entry name" value="HNH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="244"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="371" mass="43014" checksum="9DDF54039FCAF69B" modified="2011-04-05" version="1">MNISLPYTPSLPIQALASSFDNVTNSYKFYWFLAILESIRKDEGRVIPVHALLARMAAMGWYPINYYRLSFGKQDQLGNVITLIMERSGITLESTPDTIANVALDHLRRKDDVGEKIKDLADYVPYRFLRPFFTDVLRGKDDWKINRRIQELAEQSFYTHQPCLYRFVNFTDNIEIHPDWYNYLQKHLAILTGFCLWHLINYLQKHNPNVPGIAGKLFKPQSRNLLQARSFWNLVLRQAGSLTCIYSGKPIFPGKYSIDHFLPWRFVAHDLLWNLIPTPKEVNASKNDNLPDPSYLEPFTSMQYQAVQSIAPMAKSEKLLEDYVVLLKVSSVEELRKMSFGQFRDSFQATIAPQLQVAANMGFSANWKYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2M3</accession>
    <name>E8N2M3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07950"/>
    <dbReference type="EnsemblBacteria" id="BAJ62829">
        <property type="protein sequence ID" value="BAJ62829"/>
        <property type="gene ID" value="ANT_07950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07950"/>
    <dbReference type="HOGENOM" id="CLU_1264755_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228097" evidence="1">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="22920" checksum="9F5F70FC41EA475F" modified="2011-04-05" version="1">MLAFALSACSASSSVPAQSAAEQTPAPAGSTDPVQMPLETRLAVGILKLEGTGWAVTAEQAKTLLPLWKAVKSLSNSDTASSEEIQALYEQIQESLTAEQLQQIQALSLTQDDLRSLMEQYGIQFNLPTGGDGTLTQEQIATRVAQRAQSGGGMPMGGPGGMPPEAGMGAGAPPGMMEQNGQQITPDPTRMAQRRGLGMNRLFLEPLIQLLEIRAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P3</accession>
    <name>E8N2P3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_08150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559241.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62849">
        <property type="protein sequence ID" value="BAJ62849"/>
        <property type="gene ID" value="ANT_08150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08150"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="OMA" id="YNHLLAM"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="314" mass="35031" checksum="79BBDA2F62D1DDB6" modified="2011-04-05" version="1">MPAIVQVQNLVKTYGNVLAVDDISFAIEEGEIFSLLGPNGAGKTTTISILSTLFPPTHGDAQIGGFSVIRDPMQVRRMIGVVPQEIALYEDLNARENLLFWGQMAGLEGKALKQRVDEILERVGLVEKARQPVKTYSGGMKRRLNIGVGLLHSPRLLFMDEPTVGIDPQSRRAILDMVKDLNRSGMTILYTTHYMEEAQELSHRIGIIDHGKMIAIGTLQELIRQVGEQEKIILTFSEEQSLTPLVETLPMLSGVRHVNMGNHTMTLVVDAAKEILPELMQWSHRQGLKIRSLQIEEPDLEAVFLHLTGRALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2R6</accession>
    <name>E8N2R6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative M19 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561407.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30400"/>
    <dbReference type="EnsemblBacteria" id="BAJ65066">
        <property type="protein sequence ID" value="BAJ65066"/>
        <property type="gene ID" value="ANT_30400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30400"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_1_0_0"/>
    <dbReference type="OMA" id="DATHLCD"/>
    <dbReference type="OrthoDB" id="1145595at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="376" mass="41803" checksum="75061F14FD340B4D" modified="2011-04-05" version="1">MIHWMIDGHLDLAYSALTFGRDLFRSVDEIREMERGTLTPQRNNGECTVAVPELQKGHTALVIASLFVVRAGVLEAWETQVYRTPQEARQRWTAQLDVYRRWCEDHPAIFRQVTSRRDLQQVIKAWQAFASAPATGEERAEHPASAYPPIGLVVMMEGAEGLREPREIEAYAAQGVRLVAPVWAGGRFCGSNRDAEAFTREGWELLDILADLGMGLDLAHMNEKSSLQALDRFEGNLCASHTACRALARQDDNQRLLSDLQIRRIVERDGVIGIALNSRWLRPGWSAGDPRESTTLKHVAAHVDHICQIAGDARHVALGTDLDGGFGRARIPAEVDTIADLPKLADILAEAGYNESDLAAIFGGNWQIFLERILPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2S3</accession>
    <name>E8N2S3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561414.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30470"/>
    <dbReference type="EnsemblBacteria" id="BAJ65073">
        <property type="protein sequence ID" value="BAJ65073"/>
        <property type="gene ID" value="ANT_30470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30470"/>
    <dbReference type="eggNOG" id="COG1630">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059379_0_0_0"/>
    <dbReference type="OMA" id="HEIAYCY"/>
    <dbReference type="OrthoDB" id="626260at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="2">
        <location>
            <begin position="84"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="396" mass="44722" checksum="887642BA4651679A" modified="2011-04-05" version="1">MPVDYQQIREQIHQKVEQLGDQAQVRQELLDEALNLLRRYAHRQDDLRALVEQVSHVTQNLRCAQPTSESLDSAFAGAPAPDGWILLAADGSQITPDPHRAVEFGVINTGLFAFKTGAIPRELVKSEILLFNELYPNHVPLGEEMLALQRDLRERRLLLEQARQEQDAENLPIFTLTDGPLELFRQPQGDEDLKKAFQAYLNVLAETRRAGIGVAGYVDRPRSDYVVALLELAKLREAQSLSAAGKERPLWGVRDIDLFAHMLPPGARSAIFEIHSLSAARFSQADEALTLCFFYLNVGTQEKPYLVRVELPRFVAQDAQQVALLQAILLDQCRQMGARPYPYALSRAHEIAVVRYEEHQLLENMILMEIHRRGGEMQRESHKLSSKHTSAGGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T1</accession>
    <name>E8N2T1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561422.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30550"/>
    <dbReference type="EnsemblBacteria" id="BAJ65081">
        <property type="protein sequence ID" value="BAJ65081"/>
        <property type="gene ID" value="ANT_30550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30550"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_0"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="250" mass="27039" checksum="324D84E289894D72" modified="2011-04-05" version="1">MKEWICGRNAVYETLRARRRQFFRLLIASGVEEKGRIEEILALCAARRVPVSRVPRPQLDSLSESHQGVALECSGYPYAGLHDILALARQRGEPLLALGLDLIQNPQNLGTLLRSAEAVGAHGVVIPLARAAGITPAVVQASSGASEHLLVAQANLAQALETFKEEADAWVVGLEGSPESEPYDRVRLDGALVLVVGNEGEGMRPLVRRHCDVLVSLPMRGKIESLNAAVAGSIMLYKALEARSRREEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V4</accession>
    <name>E8N2V4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561445.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30780"/>
    <dbReference type="EnsemblBacteria" id="BAJ65104">
        <property type="protein sequence ID" value="BAJ65104"/>
        <property type="gene ID" value="ANT_30780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30780"/>
    <dbReference type="HOGENOM" id="CLU_1583163_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="168" mass="17792" checksum="7341CEDB88993FDE" modified="2011-04-05" version="1">MGYVCDTQMSLFIPPADIVKTAGTWTTSLSANVVKEDRTPADGVFNLIVPLGVTGNSASFKGARIKRVDLLYKVSGGACDSIPTVEVEKVTFSAGGTASGAALVATLDSGHDTDAKRKALGDHRMMVTLTSPAWLDDDEACYLYVNVDASATTQFALYGAVVYFDLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2X5</accession>
    <name>E8N2X5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tungstate ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_30990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561466.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30990"/>
    <dbReference type="EnsemblBacteria" id="BAJ65125">
        <property type="protein sequence ID" value="BAJ65125"/>
        <property type="gene ID" value="ANT_30990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30990"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="AQQCHRI"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ65125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="243" mass="27680" checksum="0D4E2BD10BDB0C8B" modified="2011-04-05" version="1">METLYRIEHLQQTYQNRTVLDVPDLSIRKGEILAVIGPSGSGKSTLLRLLAFLETPTRGQILFDNFPFTPLTAEMPLALRRRVTLVFQRPVLFNASVRANVAYGVRLRGEHNHHQRVEQSLREVGMEKMVHVRAHTLSGGEIQRTALARAIVLQPEVLLLDEPTANLDPYNVRLIEELIQRLNRQQGMTLVVVTHNVFQARRLAHRTALLLEGKLIEVAETPSFFEHPADSRTRAFIQGEWIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N314</accession>
    <name>E8N314_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561505.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31380"/>
    <dbReference type="EnsemblBacteria" id="BAJ65164">
        <property type="protein sequence ID" value="BAJ65164"/>
        <property type="gene ID" value="ANT_31380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31380"/>
    <dbReference type="HOGENOM" id="CLU_1745891_0_0_0"/>
    <dbReference type="OrthoDB" id="2170179at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="149" mass="15872" checksum="9B59A0AE275847C2" modified="2011-04-05" version="1">MKKGWLILYGILMIAMSTVLVAYLSVLLAMQGVSLPWILALPNGYAVKNALVLIPGILLGGMIAWISHSLAVKKNNTFFYYAGPIVIILVVAAVALALYGGACGYCKAVVCSPKPVSECGIKTKLSITLFEIYCKCSTGSLPMWQALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N367</accession>
    <name>E8N367_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative prolyl-tRNA synthetase</fullName>
            <ecNumber evidence="3">6.1.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_08470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559273.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08470"/>
    <dbReference type="EnsemblBacteria" id="BAJ62881">
        <property type="protein sequence ID" value="BAJ62881"/>
        <property type="gene ID" value="ANT_08470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08470"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_0"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="2">
        <location>
            <begin position="230"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="HGTP_anticodon" evidence="1">
        <location>
            <begin position="451"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="545" mass="59948" checksum="6E0FD8648C084E4C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N380</accession>
    <name>E8N380_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559286.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08600"/>
    <dbReference type="EnsemblBacteria" id="BAJ62894">
        <property type="protein sequence ID" value="BAJ62894"/>
        <property type="gene ID" value="ANT_08600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08600"/>
    <dbReference type="eggNOG" id="COG3937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2153052_0_0_0"/>
    <dbReference type="OMA" id="ANKWIID"/>
    <dbReference type="OrthoDB" id="1550797at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008769">
        <property type="entry name" value="PhaF_PhaI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38664">
        <property type="entry name" value="PTHR38664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="111" mass="12456" checksum="259EFF1AE4705A79" modified="2011-04-05" version="1">MSEEKKSRGTLYDVTRTILLAAVGAASLAQDELTHFVDRLVERGEMAEADARKLVKEVMDRRERLERERKQQMEKQAAGEAVTKADIEALTARIAELSRQIEELKKAQGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3D4</accession>
    <name>E8N3D4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GGDEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09140"/>
    <dbReference type="EnsemblBacteria" id="BAJ62948">
        <property type="protein sequence ID" value="BAJ62948"/>
        <property type="gene ID" value="ANT_09140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09140"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_16_0"/>
    <dbReference type="OMA" id="TPEYDIL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="82"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="217" mass="24588" checksum="097401692BFE45FB" modified="2011-04-05" version="1">MAKNKVIACFSLISVKPHVYTPYHASLLATFCSEAALALQNARLFSEVQQLATLDDLTGILNRRQLFIEGKREFSRAKRHHRPLSLLMIDLDHFKEINDTFGHAVGDEALKFLAHIIRKTIREVDIFGRYGGEEFVLVLPETPKQEAAGIAERLRKLIEQSPVSTPEGELRITVSVGVAEQHELTQTFEDLIGYADQALYHAKQSGRNRVEMYDEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3G1</accession>
    <name>E8N3G1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_09410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559366.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09410"/>
    <dbReference type="EnsemblBacteria" id="BAJ62975">
        <property type="protein sequence ID" value="BAJ62975"/>
        <property type="gene ID" value="ANT_09410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09410"/>
    <dbReference type="eggNOG" id="COG2120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049311_2_3_0"/>
    <dbReference type="OMA" id="EAYRCIA"/>
    <dbReference type="OrthoDB" id="1380748at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="257" mass="28266" checksum="DB09E09D19340E9A" modified="2011-04-05" version="1">MNILAFFAHPDDETMLCGGTLALLARAGAQVHLLIATRGEGGENGDPPVCPREKLGEVRAEEMRCAAEKLGAASLRFLSYVDPLVGPDDTLYAFTEDEETLVSELIEVLQSVHAEALISHGSNGEYGHPAHRLCHRAARKAIERLGTRALLFYTIQAAHPEHPRPRLANPQDPAHLILDTRSVHEVKVAAALCHRTQHALFVRNTSRELGCPVTVPEVIRDWESLHRVYPAVTRLPVEDRLAILLKSTGCARDPDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3M2</accession>
    <name>E8N3M2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tufA</name>
        <name evidence="7" type="synonym">tuf</name>
        <name evidence="10" type="ordered locus">ANT_10020</name>
        <name evidence="11" type="ordered locus">ANT_19020</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="10">UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559427.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10020"/>
    <dbReference type="EnsemblBacteria" id="BAJ63036">
        <property type="protein sequence ID" value="BAJ63036"/>
        <property type="gene ID" value="ANT_10020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63928">
        <property type="protein sequence ID" value="BAJ63928"/>
        <property type="gene ID" value="ANT_19020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10020"/>
    <dbReference type="KEGG" id="atm:ANT_19020"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_0"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="400" mass="44255" checksum="9560A944C68F7B23" modified="2011-04-05" version="1">MAKQKFERTKPHLNVGTMGHIDHGKTTLTAAITKYCNLLGKAEFKAYDQIDNAPEEKARGITINIAHVEYETEKRHYAHVDMPGHRDYIKNMITGAAQVDGAILVVAAPDGPMPQTREHVLLARQVEVPSIVVFLNKVDMMDDPELLELVEMELREMLNGYGFPGDTTPIVRGSALKALECPSKDPNAPEYACIKELLRVVDEYIPEPPRPVDQPFMMPVEDVFSIKGRGTVVTGRIERGRIKVGEPVEIVGLREKSMSSVVTGVEMFHKTLDEGIAGDNVGLLLRGVERTDVERGMVIAKPGSITPHTRFMSEVYVLKKEEGGRHKAFFNGYRPQFYIRTMDVTGTIKLPEGVEMVMPGDNVNLEVELIVPVALEQGSKFAIREGGLTVGAGVITKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Z6</accession>
    <name>E8N3Z6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559548.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11260"/>
    <dbReference type="EnsemblBacteria" id="BAJ63160">
        <property type="protein sequence ID" value="BAJ63160"/>
        <property type="gene ID" value="ANT_11260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11260"/>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1439541_0_0_0"/>
    <dbReference type="OMA" id="WPRNEEN"/>
    <dbReference type="OrthoDB" id="1631335at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="19239" checksum="E698492527A3D11D" modified="2011-04-05" version="1">MAKNTSKPNTVVLAAHGIPPSNYPGMKVGLLMMLEILNEKAHWGFLQKWHARLDQEVRTWKRTPQTDPYKTAVEALAKKLSERLGIPVLVGYNEFCAPTVAEAIEKALSLGASTVQVVSTMLIRGNTHTESEIATTVQEVAQAHPEAKIVYAFPVEEDLIISLLETHLHRFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N424</accession>
    <name>E8N424_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_11540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559576.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11540"/>
    <dbReference type="EnsemblBacteria" id="BAJ63188">
        <property type="protein sequence ID" value="BAJ63188"/>
        <property type="gene ID" value="ANT_11540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11540"/>
    <dbReference type="eggNOG" id="COG5305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041024_0_0_0"/>
    <dbReference type="OMA" id="PLFINHA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="63"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="500" mass="57353" checksum="926EA7BA35069B88" modified="2011-04-05" version="1">MSRVLERIESSWLGKASVFLIALAVRLLGIHSRPFHYDDVFSIFLAQRSLPEIIQGTAADTMPPLYYFLLHYWVQISDTDWFIRLLSILLSLLAIGLLMNWVQEMSDSRTALVAGFLAAISPFHYYHAQDVRNYALLLSAQTAFLWFFVRLWKSQDQPFSRRAGDWIGLALSGTVAMYTHNVAILGLAPAPLYLLFRRKWNFLLQVVVAFLLIAIFSVPWLAILPTQLAKIQYDWWLWRPGVVDWLQVPLVWVTGLPLTGIWLWIGALVALETFVLVTWEFSRRHVAGEWTGFLWVVMLVIPVLFFTASYLFKPVFVPRGFILSSFAFLAMAAHGIVQRWQQGGGKIILAGFVLGALIGIPVQANFLDFPRAPFRQVAHELAARITPGDLIVHENKLSYFPVKYYRPDLPQVFLADIPGSGNDTFARGSQEAMQIFPQPDIQRAVQGARRVYFVVFQQAVEDYQRLGFGEHPVLVWLRSHAVEENRMNYRDLWVYVFRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N435</accession>
    <name>E8N435_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium chelatase, ChlI subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11650"/>
    <dbReference type="EnsemblBacteria" id="BAJ63199">
        <property type="protein sequence ID" value="BAJ63199"/>
        <property type="gene ID" value="ANT_11650"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11650"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_0_1_0"/>
    <dbReference type="OMA" id="FAIDCIQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="76"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="394" mass="44074" checksum="DC85C3EB0D383FB7" modified="2011-04-05" version="1">MSEHPSFEIPEPKDYLLTRTVKSLKELVDLVSGKAFQSEVNREDAGLAEIMPFPFLALVGQQEMKLALLLAIINPLVNGVLLIGPRGTGKTTTARSLIDLLPEVQRSTCFYGCLPEDIEQGGMDAVCPDCAKKYAEGIPLTRTDRVRLIELPLNAKLEDVVGALDEHAPGHLRMRIRRGILAQADQNVLYVDEVNLLSDDIINAILDAASSGTYTLRRNLVAATYRSRFTLVGSMNPEEGNLRPQIMDRFGLRVVVHGLDNLDERLEAYRRARAYRLNPRATVAQYAEETAQARAEIQVARSLLSKVEIPTEVARAGSELVRQFQVESLRAEITLFEAARAYAAADGRTTVTMEDIKMVAPMALRLRRSAFMIQYFREQSREEEEMRKILDTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N449</accession>
    <name>E8N449_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chromosome partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">parA</name>
        <name evidence="2" type="ordered locus">ANT_11790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559601.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11790"/>
    <dbReference type="EnsemblBacteria" id="BAJ63213">
        <property type="protein sequence ID" value="BAJ63213"/>
        <property type="gene ID" value="ANT_11790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11790"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_0"/>
    <dbReference type="OMA" id="IIHEARA"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="260" mass="28608" checksum="6098D823627228E9" modified="2011-04-05" version="1">MAYLIAIANEKGGVAKTTTAVSLGAALVEAGQSVLLVDLDPQANLSMAVGVEPVPSPRSMMSVFQDSGSLHEHVVETGIPGLDIIPAAFDLGMAERFLPIRNGYEALLRRYLRSSSWKYDTILLDCPPFLGALTVNALAAADMLIMPTQAEYFSVSALRTMMGLIRKVRNEHNPQLLYRLLLTMYDRRNRIHRTLAEQLRVTFGNGVLETVIEVDTRLRESAIAGLPIIYHSPHSRSALQYRALSQEILAYVKETSAEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N459</accession>
    <name>E8N459_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_11890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559611.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63223">
        <property type="protein sequence ID" value="BAJ63223"/>
        <property type="gene ID" value="ANT_11890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11890"/>
    <dbReference type="HOGENOM" id="CLU_1253792_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="220" mass="23738" checksum="C91E2C355430043F" modified="2011-04-05" version="1">MRKTLLTVGIILLLAFAGVVVVTRWLLPGVSQKVAEPLATNPPAPPLREAGNLQQMKESLFDPALDVTMRENLTEKIELAQKVQQAVQESAASPAPKDPPALPQYSMSTVMGEWQSASGIYEGSDGLVRPEDATIANYWQGVVAGKGMAVLAGADAADPSQSLLIILTTELPDGASTYQRILLKEKAGKIRILQADFPRLVLQSAEGQQWIFNVETLSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N467</accession>
    <name>E8N467_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_11970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559619.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63231">
        <property type="protein sequence ID" value="BAJ63231"/>
        <property type="gene ID" value="ANT_11970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11970"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078180_0_0_0"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="310" mass="34489" checksum="63799001A727363C" modified="2011-04-05" version="1">MKFLWLKPSTRAYLKEGRKTRDFSFFDLIHGYIYLRFPYLYISLAKGDHPLSRRLAPLLGFLGRLIEAQAKKNGQPTGFADTYHGKVMPVEEAKRLVSIKQPIRVENLEQVIPFTRARDLILENPDHIAVLDCPCRAGKPHPCLPLDVCLIVGEPFVSFVLEHHPKRARRITSEEAMKILEDEDERGHVHHAFFKDAMLGRFYAICNCCSCCCGAMKAQREGTPMLISSGFVSVVDEDKCIACGTCAGVCPFGAIQVNGHAVIVAESCMGCGICVRHCSQGALSLQRDPSRGEPLEILHLIESTPYSTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B5</accession>
    <name>E8N4B5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12450"/>
    <dbReference type="EnsemblBacteria" id="BAJ63279">
        <property type="protein sequence ID" value="BAJ63279"/>
        <property type="gene ID" value="ANT_12450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12450"/>
    <dbReference type="HOGENOM" id="CLU_2598379_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="79" mass="8681" checksum="E7AE8E6ED7909DB9" modified="2011-04-05" version="1">MGFVWAYLTPLAIQNQKALQVLEGLVTTVRDLWGRSQAIPLTGTTSRPSLEIPGKEGLSSSLEFSKECHISPEVWLIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C6</accession>
    <name>E8N4C6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63290">
        <property type="protein sequence ID" value="BAJ63290"/>
        <property type="gene ID" value="ANT_12560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12560"/>
    <dbReference type="HOGENOM" id="CLU_1033058_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225467" evidence="2">
        <location>
            <begin position="23"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="269" mass="29364" checksum="77DF3B23A27A8744" modified="2011-04-05" version="1">MRSLWLFPLTVISIILFTGCHAQGVTPVLQVSETPTLTSTPNPPTSTHTPTVTASPSATPTVTPSPSATVTATPTFTPSPIPTYTKLRAKVIIDQAVCHYGPGAPYLYKYGVYKGSNIEVLRRVIGSNYVEIQAIGGSNRCWVRADYLEFKGDWLTLEPVSAWDVKLPISPYYPSPGGVTAKREGNEIIVSWNPLLLRAGDDSEQTPYIIEAWICVHGEMIFKPFGTYQTSVRIPDEPGCSEASYATFIAAEKHGYTPRVEVPIPPHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E6</accession>
    <name>E8N4E6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">speE</name>
        <name evidence="6" type="ordered locus">ANT_12760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559698.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12760"/>
    <dbReference type="EnsemblBacteria" id="BAJ63310">
        <property type="protein sequence ID" value="BAJ63310"/>
        <property type="gene ID" value="ANT_12760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12760"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_1_0_0"/>
    <dbReference type="OMA" id="LWPGQSF"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="280" mass="31795" checksum="FE9F68BA23CC3661" modified="2011-04-05" version="1">MNEIWFSEQLHPYYRKSLRVKQVLVDEQTPFQHLLLLDTEFFGKTLVLDGIIQLTERDNAGYHEMITHIPMLAHGSPRRVLIVGGGDGGSLQQVLKHPSVEEAIVCELDRRVVEVSREHFTAFGDPWADPRARLVVQDAFAFLESGKEKFDVIISDTTDPIGMAERLFSEEFYRLMLQALNPGGAIATQCEQMFFDAALIREIFTFVKGLVEHPAYYHTLIPTYPGGGIGFMYVSNTPWTAGLSRTYPEGLNYMNPKVHQAAFALPEFFRRQLADLLVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4P5</accession>
    <name>E8N4P5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">ANT_13810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559793.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13810"/>
    <dbReference type="EnsemblBacteria" id="BAJ63409">
        <property type="protein sequence ID" value="BAJ63409"/>
        <property type="gene ID" value="ANT_13810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13810"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_0"/>
    <dbReference type="OMA" id="CTPHDAD"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="334" mass="35783" checksum="DCF3EEE991A49705" modified="2011-04-05" version="1">MALFTRELGIDLGTTNTIIVEGNQILINEPTVVAVVVAEQKMVESGRAARDMYGRVSDAIEVVWPLQHGVIAEYEKTENFLKFLVRKVSGPMQLFPPRIMLTVPYGVTSVESRAVHEAGLGAGREVFLIPQPIAAALGVDLPIGTPSGNMVLSIGGGTVQAAVLAMYDIVRAETLRTGGIRMDEAIISYVRKKYGVIIGQPTAEQLKIRLGAAIPQDQQQTMEVQGQDQVSGLPKPVSLTSEDIIEALQEPLQEVVACAKRVLEKTPPELIADIIDRGVALCGGGALLKGIDRYLTKALGIPAYLVDNPTTCTAEGAARAFSMREALSRSLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z0</accession>
    <name>E8N4Z0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-peptide hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acylaminoacyl-peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_14760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559886.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14760"/>
    <dbReference type="EnsemblBacteria" id="BAJ63504">
        <property type="protein sequence ID" value="BAJ63504"/>
        <property type="gene ID" value="ANT_14760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14760"/>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_3_2_0"/>
    <dbReference type="OMA" id="WFSMPLI"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="6">
        <location>
            <begin position="429"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="635" mass="71503" checksum="F76AF1A69BEB52BE" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Z5</accession>
    <name>E8N4Z5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative aldehyde oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_14810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559891.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14810"/>
    <dbReference type="EnsemblBacteria" id="BAJ63509">
        <property type="protein sequence ID" value="BAJ63509"/>
        <property type="gene ID" value="ANT_14810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14810"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_3_0"/>
    <dbReference type="OMA" id="THYYQTV"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="939" mass="100952" checksum="8E76591680953756" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N513</accession>
    <name>E8N513_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63527">
        <property type="protein sequence ID" value="BAJ63527"/>
        <property type="gene ID" value="ANT_14990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14990"/>
    <dbReference type="eggNOG" id="COG3001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036517_0_1_0"/>
    <dbReference type="OMA" id="GSFYSAY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="PTHR12149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="297" mass="33660" checksum="2BE966830F8149C6" modified="2011-04-05" version="1">MNPPLKVQRSILQHLGLPLDTLVQTKPVSGGCIHHGVRLLAGEKSYFLKWNCGSLASVFPSEVDGLSRIAQKGVIKTPGVIALGTPEELEGCGYLLLEWISASPSPTLLSFRKLGEQLALHHLKTDSVFFGLDIDNYIGSTPQKNSPTANWVEFFRTQRLQFQFELALKNHLLTETQRKRLQKLMDHLEKWLPATPKPSLLHGDLWIENVLFDIEGTPILIDPAIYYGDREADLAFTELFHGFPADFYRAYQSVFPLEPEYQERKVLYNLYHLLNHLNIFGESYGAAVDRILIQYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N587</accession>
    <name>E8N587_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_15730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63601">
        <property type="protein sequence ID" value="BAJ63601"/>
        <property type="gene ID" value="ANT_15730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15730"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031877_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="118"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="394" mass="44535" checksum="8CB1A9E786BF48FA" modified="2011-04-05" version="1">MDISSLFSRFFPAHGPIPPGNYRGNLYTQSSLPNKAHLRVEKDGNGILILNGSLVLHLNQTATELAYYLIQNIPLEKISKNIRKRYGVSQEQSVADIQKFISQIDTLLNIPDLDPVAYLGIERTEVNTGAISAPYRLDCALTYRHPDNSFLRSAPVERVKSELRTEKWESILRKASDAGIPHVIFTGGEPTLREDLSALIHFSSQLGMITGLLTTGCTFNESNISQLINECGLDHIMIIFSESDHGIWNTLRLLIEQDIFLTVHLTITSRNRPQYIEWIENLQNLGVKNLSLSTNAFELKDEVLWARNKISEMGFRLVWDIPVPYSHLHPVSLEIALSEESNTFTRYPSLYVEPDGDVLPAQGDFQILGNLLHDSWESIWNAALERRRVTRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N595</accession>
    <name>E8N595_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559989.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15830"/>
    <dbReference type="EnsemblBacteria" id="BAJ63609">
        <property type="protein sequence ID" value="BAJ63609"/>
        <property type="gene ID" value="ANT_15830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15830"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_0"/>
    <dbReference type="OMA" id="VRWMERI"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="308" mass="34558" checksum="D1BC20ED89270B12" modified="2011-04-05" version="1">MKILVTGGAGFIGSHVVDQFIEAGHDVVVVDNLSTGREKNLNPKARFYRVDIRDPELRKVFEIEKPEVVDHHAAQMNVRRSVADPLYDADVNVRGSVHLLELCREYGVRKIIYISSGGAVYGEPVYLPCDEEHPVRPLCPYGLTKYAFELYLYIYQQNYGIDYTVFRYPNVYGPRQDPLGEAGVIAIFTGQMLRGEPVTIYGTGDQVRDYVHVYDCARANLLALESGSGRVYNLGSGKGTTVNELFQRLKAITGYSGMPNYAPAKLGETFKIYLNAQRAKEELGWVPTISLEEGLRNTVEYTKQSEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5F4</accession>
    <name>E8N5F4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_16420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16420"/>
    <dbReference type="EnsemblBacteria" id="BAJ63668">
        <property type="protein sequence ID" value="BAJ63668"/>
        <property type="gene ID" value="ANT_16420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16420"/>
    <dbReference type="eggNOG" id="COG1430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_4_2_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="121" mass="13890" checksum="72696B6F5D663249" modified="2011-04-05" version="1">MLVRVINHTHPYSPWITAKYCDRFFCRLKGLMFSSALDEKEGLLLVEAGDSRIGASIHMLFMRFDIGAVWINSSMKVVDQKLAHRWQSNLMPSAPAKYILEVHPSQLKNFHIGDEISFEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J1</accession>
    <name>E8N5J1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable glycine dehydrogenase (decarboxylating) subunit 1</fullName>
            <ecNumber evidence="4">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glycine cleavage system P-protein subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine decarboxylase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine dehydrogenase (aminomethyl-transferring) subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">gcvPA</name>
        <name evidence="5" type="ordered locus">ANT_16790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvP family. N-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560084.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16790"/>
    <dbReference type="EnsemblBacteria" id="BAJ63705">
        <property type="protein sequence ID" value="BAJ63705"/>
        <property type="gene ID" value="ANT_16790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16790"/>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_0"/>
    <dbReference type="OMA" id="MYDGASA"/>
    <dbReference type="OrthoDB" id="870147at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00712">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006815">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="451" mass="49583" checksum="BDBFEF3C73D5BEF9" modified="2011-04-05" version="1">MFVPNADPDREAMLKTIGVERIEDLFTDVPEGYRFPKLNLPEALSEMEAYAHLSELAQANSSVRDLTCFLGAGAYHHYIPAVVDAIIQRGEFLTAYTPYQPEVSQGTLQAIFEYQSLMALLTGMEVCNASHYDGATAAAEAVIMAYHHFRGKRTKVLVSHALHPQYRATIRTYMQGYTQLTITGDECTDCDPLAGPEVLLRAIDTNTALVIVQYPDFLGRIYDYTELANTAHQAGALFAIAVNPIALGLLKPPGEFGADIVIGEGQPLGIPLSFGGPYLGIFATRKEFVRKIAGRLVGETVDQDGKRAYVLTLTAREQHIRREKATSNICSNQGLMALASTVYLSLLGKQGLRQVAELCYQKAHYAADLISQIPGYTVCSNAPFFHEFVVCCPKPVSEINQALLEYGILGGFDLSTDYPGLKNAMLIAVTEMNTREEIETLRDVLEDISHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J9</accession>
    <name>E8N5J9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_16870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560092.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63713">
        <property type="protein sequence ID" value="BAJ63713"/>
        <property type="gene ID" value="ANT_16870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16870"/>
    <dbReference type="HOGENOM" id="CLU_917150_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="303" mass="35611" checksum="F20ACAE26476E21B" modified="2011-04-05" version="1">MNMISFIEELKGLVPSEDVPWILQSIRQDERIEQFITTSGGFSRVKRFLGPDPVNWSPGQIALLSLCDDDFSGECSAHFYEDLIASLEKQASDFLEEVLHQRKKVVSLGESALLGIALRNLAHREGWQTAFEKITHKDRRDTYSLWKTAILVSGDLQEEPLEWAKHLFIEFYEPLIWEWGIHWLSSRFLPLDRKIEITVELLVKAVPLVQIEVLQRLMARECRQWSQKVAKTLLDNHPLLNSYRKKVDLIVLMLLKFCSMRYLFINWLRYTPLQEKPHFLNPFIEPPYMLCNTGKRKRPFIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T3</accession>
    <name>E8N5T3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63797">
        <property type="protein sequence ID" value="BAJ63797"/>
        <property type="gene ID" value="ANT_17710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17710"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061778_0_1_0"/>
    <dbReference type="OMA" id="VFMTQDA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="321" mass="37538" checksum="E3863077760AB654" modified="2011-04-05" version="1">MNCSIVIRAFNESRHLPRLLEGIRHQTVQDVEVILVDSGSTDSTVAIAQSYGAKICHIPSREFTFGRSLNLGISESTREFIVIASAHVYPVYPDWLERLLEPFSDPQVGLTYGKQRGPQTAKFSEKQIFYQWFPEKSNWQQNTPFCNNANAAIRRFLWEKHPYDETLTGLEDVAWAKWAVSQGYRVAYVSEAEIIHIHQETPKGVYNRYRREAMAFKRIFPEAHFSLYDFFRLSIENIFYDTWYALRQKTPLGDITSIFWFRLMQFWGTYRGYRHPGVVTPQLRETFYYPRGIQNVGDEQRQDVDPISYSAENSQKTALKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U3</accession>
    <name>E8N5U3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_17810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560185.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17810"/>
    <dbReference type="EnsemblBacteria" id="BAJ63807">
        <property type="protein sequence ID" value="BAJ63807"/>
        <property type="gene ID" value="ANT_17810"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17810"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_0"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="159" mass="17967" checksum="DB34F0D4BDF64C7A" modified="2011-04-05" version="1">MSNEQPNGKNILEIVRHAVEVHGKTREELIPILQEINRQYGFIPSQGLEEVARLLQIPKSQVFSVATFYHMLNVKEMGRHIILFCESAPCHVVGGREVWRRLKQELKIDAGETTPDKKWSLVTVSCLGVCGVGPVIVIDEDMYGNVTPEMIPDILARYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y7</accession>
    <name>E8N5Y7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63851">
        <property type="protein sequence ID" value="BAJ63851"/>
        <property type="gene ID" value="ANT_18250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18250"/>
    <dbReference type="eggNOG" id="COG2345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1340949_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="204" mass="23772" checksum="D9226EA1E6CFA96B" modified="2011-04-05" version="1">MSLSTRETILRLFAQKGVLTSDEISQALGISPVDVRYHLKALLKEKRIEKYSPELQSKRRVGRPPQQYRLSPTSHPENLEMLILSLLDQMSTFLPNTELWKKIAETIIPETPEQPFPSKLRHAMVVLERLHYEPRWEATQTGPKILFHCCPYASIWKHHSQICVMDRKILERLTGISFFHQSCMHKSIEHICVFLPEKPDFSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N615</accession>
    <name>E8N615_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">smpB</name>
        <name evidence="4" type="ordered locus">ANT_18530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560256.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18530"/>
    <dbReference type="EnsemblBacteria" id="BAJ63879">
        <property type="protein sequence ID" value="BAJ63879"/>
        <property type="gene ID" value="ANT_18530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18530"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_0_0"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="157" mass="18027" checksum="4840119E0C8F298C" modified="2011-04-05" version="1">MAVKNVKVVATNRKAQFEYFLLERYEAGIALQGSEIKSVRAGQVSLAEAFVQVDGREAWLVNAHIAPYNPASRFNHDPRRPRRLLLHKREILELWNAVRAKGVTVVPVSIYLKEGKAKVEIAIAKGKKLYDKRAAIAEREAEREARREHREREKEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N636</accession>
    <name>E8N636_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_18740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560277.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18740"/>
    <dbReference type="EnsemblBacteria" id="BAJ63900">
        <property type="protein sequence ID" value="BAJ63900"/>
        <property type="gene ID" value="ANT_18740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18740"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038716_5_1_0"/>
    <dbReference type="OMA" id="EGNWPRD"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="356" mass="39525" checksum="34D96EC6613CBB73" modified="2011-04-05" version="1">MTRFVYVGTYTQTEPSKPHRQEGIFVYVMNPVTGKLTFSSSTSGLNPSFLAFHPRKHVLYAVNELEEGMVSAFAIHPQTGALNLLNSQPTQGAHPCYVSVDRQGEWVMCANYTGGSISLHPVLSDGSLGEISDWRQHQGVLGPNHARQETPHAHSIDFDPSGNYLLAADLGLDRIFIYRLERTQGKFLIHGEISLPPGAGPRHFTFTSNGRCLFVANELGSSVSILDWDLEKGKAEMVETVSTLPPDFSGENIVADIHLSQDETFLYVSNRGHDSLAIFRVWGNRVPKLLPVMYASIQGSWPRNFSIDPTGRFILVANQYSDNVVLFHRDRETGEIQPAGFSVEVNSPVCIKFYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXE9</accession>
    <name>E8MXE9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB</name>
        <name evidence="9" type="ordered locus">ANT_20040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560401.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20040"/>
    <dbReference type="EnsemblBacteria" id="BAJ64030">
        <property type="protein sequence ID" value="BAJ64030"/>
        <property type="gene ID" value="ANT_20040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20040"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_1_0"/>
    <dbReference type="OMA" id="LYRPKMG"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="660" mass="75759" checksum="63895771B98894AD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXF9</accession>
    <name>E8MXF9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_20140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560410.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20140"/>
    <dbReference type="EnsemblBacteria" id="BAJ64040">
        <property type="protein sequence ID" value="BAJ64040"/>
        <property type="gene ID" value="ANT_20140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20140"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_0"/>
    <dbReference type="OMA" id="WRTYENT"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="315" mass="35624" checksum="66B1D7C88E6E6857" modified="2011-04-05" version="1">MMNLSVVIPVYNSEKSLPELIQRLNTVLPQIAEQYEILMVNDGSIDGSWKCIQRYSQEYPWIRGINLMRNYGQHNALLCGIRAAKYPITVTMDDDLQHLPEAIAQLLEKIREGFQVVYGRPVKEQHNLWRDLASQVTKIALQNAMGAETARNVSAFRAFHTQIREAFSQYQGSYPSIDVLLTWGANRFTSVPVQFQSRRYGNSQYTFAKLVRHAINMITGFSIVPLQLASLIGFSFTLFGLGVLAYVIGRYILQGGSVPGFPFLASIIAIFSGAQLFALGIIGEYLARMHFRLMERPTYTIQEVTDTKEHISDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXJ1</accession>
    <name>E8MXJ1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">nnrE</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="18" type="ordered locus">ANT_20460</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20460"/>
    <dbReference type="EnsemblBacteria" id="BAJ64072">
        <property type="protein sequence ID" value="BAJ64072"/>
        <property type="gene ID" value="ANT_20460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20460"/>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_0"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="15"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="136"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="453"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="BAJ64072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="547" mass="58473" checksum="35879E006ACF3FCB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXM9</accession>
    <name>E8MXM9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560480.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20840"/>
    <dbReference type="EnsemblBacteria" id="BAJ64110">
        <property type="protein sequence ID" value="BAJ64110"/>
        <property type="gene ID" value="ANT_20840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20840"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_2_0"/>
    <dbReference type="OMA" id="PRCIGNQ"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="110" mass="12389" checksum="F5F3C35705CEA36C" modified="2011-04-05" version="1">MAKKEIPPLQQLSPEQKRLILMLKALGNPIRFRIMQFLAEKQMCITGDVVEFTTLAQSTVSQHLKVLRDAGLIKGEIEGPATCYCISEEGVQFLKEYIESWLPGCCSETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXN4</accession>
    <name>E8MXN4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ftsH</name>
        <name evidence="9" type="ordered locus">ANT_20890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20890"/>
    <dbReference type="MEROPS" id="M41.021"/>
    <dbReference type="EnsemblBacteria" id="BAJ64115">
        <property type="protein sequence ID" value="BAJ64115"/>
        <property type="gene ID" value="ANT_20890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20890"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_0"/>
    <dbReference type="OMA" id="YDKQGGG"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="196"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="623" mass="69059" checksum="DBE87BFCC665122E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT0</accession>
    <name>E8MXT0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_21350</name>
        <name evidence="4" type="ordered locus">ANT_24000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
            <strain evidence="3">UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21350"/>
    <dbReference type="EnsemblBacteria" id="BAJ64161">
        <property type="protein sequence ID" value="BAJ64161"/>
        <property type="gene ID" value="ANT_21350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64426">
        <property type="protein sequence ID" value="BAJ64426"/>
        <property type="gene ID" value="ANT_24000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21350"/>
    <dbReference type="KEGG" id="atm:ANT_24000"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057454_1_0_0"/>
    <dbReference type="OMA" id="LAHIWIG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="401" mass="44954" checksum="B5A9A244F538AFD3" modified="2011-04-05" version="1">MNPSGRISSSPRLKITPSLLKWARERSLLDFNTLARKTGVKPEVLQSWEQGETAPTYRQAEKLAHALHIPFGYLFLSQPPFAPSAVPDFRRLPESQIGRFSPELESVLNDAKRKQAWLHEWRVEEGFSPLPFIGKFSPEDSPQTVAEQIRSVLDLPSPTAKGLYSWNEHLQKLVKHAEKAGIAVIRNGVVLSDNRRPLSVEEFRGFNLPDNYAPVIFINAQDSIAGQIFTLAHELAHLWIGAGGISNPLTADNPLDTSETERFCNRVAAELLLPQNPFLEHWPSGTTTLPEILNAAQQLAREFKVSAPAVLLRACELNRLDAPLFRAAYEEIYRQVIPLRKKTGGGSFYATWQARNSQTVVTEVLQALRQGKVLYRDAARLLNTNLATLEKALNRMKTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY53</accession>
    <name>E8MY53_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_22580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560652.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64284">
        <property type="protein sequence ID" value="BAJ64284"/>
        <property type="gene ID" value="ANT_22580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22580"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_388654_0_0_0"/>
    <dbReference type="OMA" id="GERIAYW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="710" mass="78542" checksum="F86159E009F2B2B7" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY78</accession>
    <name>E8MY78_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_22830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22830"/>
    <dbReference type="EnsemblBacteria" id="BAJ64309">
        <property type="protein sequence ID" value="BAJ64309"/>
        <property type="gene ID" value="ANT_22830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22830"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791535_0_0_0"/>
    <dbReference type="OMA" id="TETRWAR"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="355" mass="38873" checksum="1EAD059BF44319E1" modified="2011-04-05" version="1">MESGRMVDLSPRWRNILKAGFIVLSLGLVGLGMYTLKDGLKGVSLSGLTTLWARLPAEFWGIWIGLNLVVILVWAWRWGVILQPLGIQASLKNRVFARLAGFGWSYFTPGPQVGGEPVQVYLISRYARVPLPLAATSVYLERVVDGLTNFAVLLLGVMAMLFLDVEWMGGIRWFGVVTGGLLIIPALHLMLLKKGRLPLTAAVMAFSGKRGTFGKKVLLQVSLAESYLSNFAQQHFFALVKSFLLSIFAWLLSVLEFSWLLSGLSESLSPLQVLCFLVLARLSFLLPIPAATGVFESAMVFAAVSLGLSPLSGIALGLTVRLRDVLLALIGVFISGRGAMTRWFDSQDLKREVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYH2</accession>
    <name>E8MYH2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cobalt ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_00830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00830"/>
    <dbReference type="EnsemblBacteria" id="BAJ62117">
        <property type="protein sequence ID" value="BAJ62117"/>
        <property type="gene ID" value="ANT_00830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00830"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_0_0"/>
    <dbReference type="OMA" id="CYILPEM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="289" mass="31977" checksum="BB9983229C3B5195" modified="2011-04-05" version="1">MLVCRGGAMSVILFQSTGRRTLFHRLDFRSKAVLMLAVTVTAFIWEDPLAQAGLALAVFLACVLGGVRWAYLRVIFLLMTPLFILLMLTHGFFNVQQVRSLLGGAPLTYLLRFPEDWWLIGGGGLTREGLLYGLNAVLKTLSVVMIVPLVIFTSDVDQVVVGMVRARVPYTLAFIFSATLRFFPLLFAEAQTIIEAQRLRGLAVERLRPWERVQVYARIAVPLILGALVRSQQLEVVLQSRAFSGSPQRTFLHESRLSPADWAVMALALGGMALAVVLRLTTGFGSFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYH5</accession>
    <name>E8MYH5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558518.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00860"/>
    <dbReference type="EnsemblBacteria" id="BAJ62120">
        <property type="protein sequence ID" value="BAJ62120"/>
        <property type="gene ID" value="ANT_00860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00860"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672026_0_0_0"/>
    <dbReference type="OrthoDB" id="1456588at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="457" mass="51002" checksum="178EDAD7E05675A5" modified="2011-04-05" version="1">MAQKYLFRKRSSSNPYTILALTVILLAMVAVLRGLQTQQIEPLFLPTPTPTRTSNSYALEGQTHFQAGNLKGAIEAYQQALQSEPSNARIWMELAQIQTYSYKSLTTREAQRQRLAEAIESANRAVELAPEDSSAYAIRAFVRDWNAGLLESDEERSRLLVEAEQDAQKALLLDKNNVLALAYSAEILNDQQKWDQARQYIQLAVERNPNLMDVWRVQAAILESFGDYQGAIQAYDRAIELAPNLTFLYVQAGVIYRHLGMTQTDKTLSAQYYATALDYFAKAVNKNKQLGIEDPVPYIAIGKVYTQMGEFFVAALNAKKALQIDPYSPDLYGQLGMVYFKARNYETAIPALQCAVEGCSPQVSCEVRECDPASDPPIEIQGIPLEPNDPTTVVYYYTYGSILAGLYRPVGETKDYCDRALNVFDKVRALYAGDSTVMGIVEASESICASFGITRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK7</accession>
    <name>E8MYK7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_23170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560710.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23170"/>
    <dbReference type="EnsemblBacteria" id="BAJ64343">
        <property type="protein sequence ID" value="BAJ64343"/>
        <property type="gene ID" value="ANT_23170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23170"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_0_0"/>
    <dbReference type="OMA" id="EHTMVRN"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="281"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="47533" checksum="2800B43C2F173F5F" modified="2011-04-05" version="1">MIFWNILLLLFLILLNGALAMAEIAVISSRQIRLQQRVEDGDKRAETALELMRSPSHFLSTVQIGITLIGILAGAVGGAQLATPLAEWIGQISWLYPYRQELALALVVLVITYLSLVLGELLPKRAAQLNPEEIAVRVAPWMKWLGKVTNPLVVLLGASTDFLLKLLGWQKVLSPDLTEEEIKGIIEQGVESGIIEQRETDMIEGVLRLGDRLVSAFMTPRTEIEWLDVEDPWEVNREYIISSSHNYFPVARGDLDNVLGIINAKELLAVATPQPVDLKDYLKPALFLPESTTALKALEALRTASGNLALILDEYGGLQGMITLFDLMEAIVGEIPSYGEETGQAIIRREDGSLLVDGSLSVDVFKQLLQVEELPEEERIGYQTVAGFVLAQMGTIPSVGQHFEWNRYRFEVVDRDGLRIDKILVKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYP8</accession>
    <name>E8MYP8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560750.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23580"/>
    <dbReference type="EnsemblBacteria" id="BAJ64384">
        <property type="protein sequence ID" value="BAJ64384"/>
        <property type="gene ID" value="ANT_23580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23580"/>
    <dbReference type="eggNOG" id="COG3557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1650850_0_0_0"/>
    <dbReference type="OMA" id="YWRDRWY"/>
    <dbReference type="OrthoDB" id="1978259at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="164" mass="19333" checksum="6FB2F655DFA144C8" modified="2011-04-05" version="1">MRQVIVRKLEPSGMEKWRYPAVVLEETEDAILVEAYFDRPVWRLKDILLNPGDRFVEIYFRYRWYNIFQIHDGKSEAIKGWYCNVCLPPEIVDGEIRYVDLALDLLVYPNGRQQVLDEDEFAELNLSEEVKKQASQALEDLKQLVDPRRGFRIEKQSRGNPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYQ1</accession>
    <name>E8MYQ1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">serS</name>
        <name evidence="10" type="ordered locus">ANT_23610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560753.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64387">
        <property type="protein sequence ID" value="BAJ64387"/>
        <property type="gene ID" value="ANT_23610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23610"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_0"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="138"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="424" mass="47915" checksum="F9E64EF1C8F81E9F" modified="2011-04-05" version="1">MLDINLFRETPDVVREALRHRQMDDSVVDRVIELDQQRRANLTRVEALKAERNAVSKEIGKTKDPAERQAKIEAMRQVGDEITALDEAVRKIEEELESTLAQIPNLPLPEIPVGESEHQNQVIKTVGTPKTFDFTPLPHWELGPKLGILDFERGVKITGSRFYVLSGAGARLQRALIAWMLDLHIRQGYREAYLPFMVKGDTLYASGQLPKFRDNLYHDIEEDLWMVPTAEVPLTGLHMGEVLDEKQLPLRYTAYTPCFRREKMSAGRDVRGIKRGHQFDKVEMYIYSKPEDSMKELQKMLADAEQTCAELGLAYRVVQLCTGDLGFGAAITYDLEVWAPGCGEWLEVSSVSNDTDFQARRAGIKYRPEDGGKPRLLHTLNGSGLGLPRTLIAVMENYQQADGSIVVPEVLRPWMGGVDVIRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYV1</accession>
    <name>E8MYV1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T2SP_E domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_24110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560793.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24110"/>
    <dbReference type="EnsemblBacteria" id="BAJ64437">
        <property type="protein sequence ID" value="BAJ64437"/>
        <property type="gene ID" value="ANT_24110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24110"/>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672027_0_0_0"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="87"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="411" mass="44323" checksum="AB81C0A6227CB37A" modified="2011-04-05" version="1">MSWLELMAQTTPEQEARIVELASGDLKNLPLAVLRDRQQLQARAQAAVSSAATRLGVSLTPQLQSALAKTVAARIGGLGAFDELLPPARTDLSEITLNPDGTLWILRKGERFFEKYNRQPGLDEVWRSVEALLAPIGRAISEAQPSVDAKLPRMEGMGGARVKIVHPVLAPGLGYPAVNIRLFEPRPVPPEQIIAWGACPQAVMDGLLEAVAGGLRVLVIGGTATGKTTFLSALAHGIPKEARIVKIEDPEEIWLPHPNVVTLEARPQVVGSDVPGYSLSDGVDDAMRMAPNWLMVGEVRTGTAALSLFRAQMSDHPGLSTLHAEGPEAAIHRLGVLMWADAQVRIEAAKEMFAMAVDLVVQVGWKDGRRQVLGVWEVNPELKAGNVTFRKLYQAGESQMAEISRRRGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ65</accession>
    <name>E8MZ65_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hepar_II_III_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558606.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01740"/>
    <dbReference type="EnsemblBacteria" id="BAJ62208">
        <property type="protein sequence ID" value="BAJ62208"/>
        <property type="gene ID" value="ANT_01740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01740"/>
    <dbReference type="eggNOG" id="COG5360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022012_1_0_0"/>
    <dbReference type="OrthoDB" id="442785at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="124"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="652" mass="72945" checksum="5E4B97C4389ED834" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC9</accession>
    <name>E8MZC9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR system Cms endoribonuclease Csm3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CRISPR type III A-associated RAMP protein Csm3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_24510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated Csm3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560832.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24510"/>
    <dbReference type="EnsemblBacteria" id="BAJ64477">
        <property type="protein sequence ID" value="BAJ64477"/>
        <property type="gene ID" value="ANT_24510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24510"/>
    <dbReference type="eggNOG" id="COG1337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067743_0_0_0"/>
    <dbReference type="OMA" id="NPVIKDP"/>
    <dbReference type="OrthoDB" id="1840881at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013412">
        <property type="entry name" value="CRISPR-assoc_RAMP_Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02582">
        <property type="entry name" value="cas7_TM1809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="264" mass="28881" checksum="9BB9581193D90F74" modified="2011-04-05" version="1">MAKAIQLKGRVLIHFDITAETGLHIGGTESGIEIGGVDKTVIRDPLTQRPYIPGSSLRGKMRSLLEKYKGLKQNQRIGQGYIHSCDDPTAYPNCDVCNIFGVPGERGFSTPTRLIVRDVFMSDESAKQLENADTDLPFTEVKTEVSIDRVTSAANPRQMERVPAGTRFDNAELVYSIYEGDGCDARKDVARLKVLVEGLQLLLDDYLGGLGSRGSGKIGISNIKVEWRGKDYAAQAQVLGSFNTVAEFAQNLAEIQNTVLSQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZG6</accession>
    <name>E8MZG6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560869.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24880"/>
    <dbReference type="EnsemblBacteria" id="BAJ64514">
        <property type="protein sequence ID" value="BAJ64514"/>
        <property type="gene ID" value="ANT_24880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24880"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_0"/>
    <dbReference type="OMA" id="APHIRRY"/>
    <dbReference type="OrthoDB" id="1377545at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="268" mass="29044" checksum="DDAC5C61F2F3DAC9" modified="2011-04-05" version="1">MKTVLITGATDGIGKQTALQLARHGWRVLLHGRNSQRGEEVVGEILDEMPHAQVEYLNADLSSLNEVRQLARTVLALTPRLDALVNNAGGFFPQRQLSRDGLEMNFAVNHLAHFLLTNLLLGLLQSSAPARVVTVSSVIHRNARLNFEDLQLEQSYNGTRAYATSKLMNVLFAAELARRMEGKGVTSNSLHPGVVATKMLQSAFPSMQGGSPVDGAATSVYLVTSPDVEGVTGKYFENKQIAPHHPLADDPEACARLWEISARLAGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZH9</accession>
    <name>E8MZH9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine 2,3-aminomutase</fullName>
            <ecNumber evidence="5">5.4.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">kamA</name>
        <name evidence="16" type="ordered locus">ANT_25010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine = (3S)-3,6-diaminohexanoate</text>
            <dbReference type="Rhea" id="RHEA:19177"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57434"/>
            <dbReference type="EC" id="5.4.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the radical SAM superfamily. KamA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560882.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25010"/>
    <dbReference type="EnsemblBacteria" id="BAJ64527">
        <property type="protein sequence ID" value="BAJ64527"/>
        <property type="gene ID" value="ANT_25010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25010"/>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032161_0_0_0"/>
    <dbReference type="OMA" id="PIWLNTH"/>
    <dbReference type="OrthoDB" id="557227at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025895">
        <property type="entry name" value="LAM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022459">
        <property type="entry name" value="Lysine_aminomutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12544">
        <property type="entry name" value="LAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00283">
        <property type="entry name" value="L-lysine_2_3-aminomutase_(LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03820">
        <property type="entry name" value="lys_2_3_AblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="116"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAJ64527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="446" mass="50755" checksum="A9C5562FB5BAF70F" modified="2011-04-05" version="1">MSPVAFPANKRAPIYRDVPDEKWNDWRWQLSHRLNSVEDFEQVLRLTESERKALTTQGLFRVDITPYFVSLINPDDPDDPIRKQVIPRAEEIVPFTGMMEDSLAEDRHSPVPGLVHRYPDRVLMLVTTQCASYCRYCTRSRIVGDPSATFSRAEFEMQIEYLKRTPQVRDVLLSGGDPLTLAPKLLEELLSRLREIEHIEIIRIGSRVPVFLPQRITQEFCDMVSKYHPVWMNIHVNHPNEITQELADACDRLTRAGVPLGNQSVLLAGVNDCVHVQRKLVQDLVRIRVRPYYLYQCDLVEGAGHFRTPVAKGIEIIEGLRGHTSGYAVPTYVVDAPGGGGKIPVMPNYLISMSDHKIILRNYEGYITTYEEPITYQPHDPKTCPYCQNKRPEPGQTGITGLLDGDAMFIKPEHFDELHNRGGGLHRLRADTEKWKPLGIGGGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI1</accession>
    <name>E8MZI1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">prmA</name>
        <name evidence="3" type="ordered locus">ANT_25030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560884.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25030"/>
    <dbReference type="EnsemblBacteria" id="BAJ64529">
        <property type="protein sequence ID" value="BAJ64529"/>
        <property type="gene ID" value="ANT_25030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25030"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_0_1_0"/>
    <dbReference type="OMA" id="EFFFIFP"/>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="308" mass="33108" checksum="007B75F19A23611D" modified="2011-04-05" version="1">MSNAPHWLEVSITVDPELGEAVSEVLSRFVSGGVVVESAVRYNDAEDEGTPYGPVKVYGYLPIDEHIEETRQKVTEALWHLGQIQPLPEPSFRTIQDEDWMAAWKQHYRPIPVGERLLILPAWMAPNPGETRIPVKIDPSMAFGTGTHPTTQLCMAFLEDTVIPGKPVIDVGCGSGILSIGALKLGASHALGVDIDQASVISTRENAEANGVLERLEVGLGSVSEILAGNFSLTHAPLVLANILAPVIIRLFDAGLADLVSPGGTVILSGILDTQAPDVLLAAAQKGLKFVEQRQINDWVALRLIKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ3</accession>
    <name>E8MZJ3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">acpS</name>
        <name evidence="10" type="ordered locus">ANT_25150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560896.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64541">
        <property type="protein sequence ID" value="BAJ64541"/>
        <property type="gene ID" value="ANT_25150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25150"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_0_2_0"/>
    <dbReference type="OMA" id="DERHYAV"/>
    <dbReference type="OrthoDB" id="1893660at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="125" mass="13575" checksum="4D74707CAE680801" modified="2011-04-05" version="1">MILRTGVDIVEIQRLEQVNPAIRERFIRRVFTPLEIELARGSYASLAGRFAAKEAVSKALGTGIGPVSWQDIEIRRDASGAPVLYLHGRAAEVARLLGLTTWSVSISHGRTHAVAMAVALGEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZK1</accession>
    <name>E8MZK1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560904.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64549">
        <property type="protein sequence ID" value="BAJ64549"/>
        <property type="gene ID" value="ANT_25230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25230"/>
    <dbReference type="eggNOG" id="COG2379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_0"/>
    <dbReference type="OMA" id="GKAAWRM"/>
    <dbReference type="OrthoDB" id="1358712at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="PTHR12227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="36"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="1">
        <location>
            <begin position="359"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="472" mass="50822" checksum="80AF017F12AD3142" modified="2011-04-05" version="1">MRPDHPEFSPGNREYPAGKVTLTPFTVDRSPIRETVRRILNAALKAVDPAQAVQRFVHRTEGCLTVHSASWNLSTFRRVRLLAIGKAAEPMAQATAEILGEYLHDGLMIVKSGSRSDQPISPKIACLESSHPIPDERSVQTGERICEFLRESTSEDFYFILLSGGASALATLPAQGVSLTDIQYLTQLLLRCGADIRQINTLRKHLDRLKGGGIARLLYPAQAVCLVLSDVLGDPLDVIASGPAVADPSTYANAWEILRQYDLEREIPESVRQILRNGMNGHLPETPKPGDALFEKVFTTVIGSNRIAAEAARQQAQEEGFHTAILTTFLQGEASVAGQFLAAIAREEVLHQSPLPLPACLICGGETTVTVKGEGKGGRNQELALGAVEGMDGLSALLVTLATDGGDGPTDAAGAVVSGETLSRARALGMSPADYLKRNDAYTFFEALGDLIKTGPTRTNVNDLAFVFVWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZM8</accession>
    <name>E8MZM8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_25500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560931.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25500"/>
    <dbReference type="EnsemblBacteria" id="BAJ64576">
        <property type="protein sequence ID" value="BAJ64576"/>
        <property type="gene ID" value="ANT_25500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25500"/>
    <dbReference type="eggNOG" id="ENOG502ZT9W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831245_0_0_0"/>
    <dbReference type="OMA" id="WIPIARA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="308" mass="33951" checksum="2E0D1BD8448D89E0" modified="2011-04-05" version="1">MSYGEVLSKAWQMIWKHKVLWIFGILAGFLSNGGNPDLSYREEYRSTAPNVFGYRLEEWLNQNFWLVALIVLAVFVLVLVLLVLGTFGRIGLVRGAWKADEGAVKLSFAELWAESGAYFWRVLGLSFLLFVVFLIVGVALGIFVVLGTVVTLGIGLICLLPFLCLLIPLAWLLQVWVEQVIVAMVGENLSIGEGISRAWQVFTAHLGEYIVMGLVLGLGSLVVRIVLSIPFLIALAPLLGAWMFNGGQVFGSTGMVLTLVLMCVYLPVYMFLNGILTAYLGTSWTLIFRRLTGRTAQPEVVEVLPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZN1</accession>
    <name>E8MZN1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_25530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560934.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64579">
        <property type="protein sequence ID" value="BAJ64579"/>
        <property type="gene ID" value="ANT_25530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25530"/>
    <dbReference type="eggNOG" id="COG4242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096867_0_0_0"/>
    <dbReference type="OrthoDB" id="2002495at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="28101" checksum="80E9167104820A95" modified="2011-04-05" version="1">MRQHLALLLNLWFTEYMLDLKANLPGKGILALVGAGEYLPEMEVVDTYLLHLLTEPVRVVCLPTAAGSEGQKRVQYWMDKGVEHFQRMGVKQVQALPLTHRNHAFHAPFVEQLQQANFVYLSGGKPAYLYQTLVNTPAWDAIQGVLQKGGVVAGCSAGAMIFGERVLASPAGTGTFQGFGFVQNACIIPHYDEIPRLMLESAAALLHRWLFVGIEGFTALIFTPQGRCVRGKGKVELRFAGERLPRFEQDGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS6</accession>
    <name>E8MZS6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_25980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25980"/>
    <dbReference type="EnsemblBacteria" id="BAJ64624">
        <property type="protein sequence ID" value="BAJ64624"/>
        <property type="gene ID" value="ANT_25980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25980"/>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024619_1_1_0"/>
    <dbReference type="OMA" id="QMDTPGG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="4">
        <location>
            <begin position="362"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="447" mass="47199" checksum="D4A3585B4DBA6E08" modified="2011-04-05" version="1">MKVEDVMGRLNWVRLVVLGLFLWAWLGTASPMQAQSDVPVVVTVRLEGALNPIWQETLKRAMRVAEDRGAEALILQLDTPGGQIDVMNRLVQQIRNSPMPVVVYVSPAGAMAASAGAMLTLAGHASAMAPETSIGAASPVGGQGEDIGETMESKVKEILKASARGLTLRRGETAVRLAEEMIENARAVSANEAVENGLVDVIASDLPTLLRKLDGLSVEFGDSRRTLNTAGAIVVEVPLTFMEQVLVVLANPNLVFLLLSIGVQAILIELSSPGGWVAGFIGAVCITFAVFGLGILPVNWFGIIFLVMAFILFVLDIQSPTHGALTAAGVASFIVGALVLFNSPNIPGTPRVSVPLVVGTGVTIGVIFFGAVAFALRAQRAPIRIGQEALLGQVGYARSDINPVGNVQLGSELWTAENVDPTTPIPRGSRVEVVSVEGIRLIVRRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZW1</accession>
    <name>E8MZW1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558693.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02620"/>
    <dbReference type="EnsemblBacteria" id="BAJ62296">
        <property type="protein sequence ID" value="BAJ62296"/>
        <property type="gene ID" value="ANT_02620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02620"/>
    <dbReference type="eggNOG" id="ENOG502ZXYX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134903_1_0_0"/>
    <dbReference type="OMA" id="IPWWRPL"/>
    <dbReference type="OrthoDB" id="1927917at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="154" mass="17391" checksum="7CAA5BB0C2C60F81" modified="2011-04-05" version="1">MYAFLLPLHNILRWLLLIAALFAVGRALWGWLARKPWQALDDRAGLIFTTVMDLQVLVGLLLYVAFSPLTQTAFQNFGGAMGNATMRFFAIEHILIMVIALVLAHIGRAQARKASEALSKHRRAAIWFGIALLLVLLAIPWPFSGVPRPLWRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ2</accession>
    <name>E8MZZ2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_02930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02930"/>
    <dbReference type="EnsemblBacteria" id="BAJ62327">
        <property type="protein sequence ID" value="BAJ62327"/>
        <property type="gene ID" value="ANT_02930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02930"/>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063199_1_1_0"/>
    <dbReference type="OMA" id="AQIIHKY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="245"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="306" mass="33363" checksum="4A17A33173C1259D" modified="2011-04-05" version="1">MDLNRITSFKSFRQKMGEMWKSIDFSRESVQDYLYVLAGALVQAFAMRLFLIPAQLVSGGISGAAQLINHYTNWPIGLMVFIGNVPLFILGWQHLGGPRFALRTALSIVAFSFFTDFLGLFLPAEGVVHDLVLNCLYGGVVLGVGLGLVYRGKGTSGGSDILGRILNERVGISISQAYLATDSAVILSAGFVFAWENALYALVVTYVSGLTAEMVLEGSNVFRTAMIITNRPKEVAERILYDMERGVTILEGRGGYTGAEREVLYCVVTRSEVSQIKSIVKAVDPNAFMVIGQAHEALGEGFRPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ7</accession>
    <name>E8MZZ7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_02980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558729.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02980"/>
    <dbReference type="EnsemblBacteria" id="BAJ62332">
        <property type="protein sequence ID" value="BAJ62332"/>
        <property type="gene ID" value="ANT_02980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02980"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_0"/>
    <dbReference type="OMA" id="GGWMAGQ"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="249"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="496" mass="54060" checksum="CF2A375E1D91EA57" modified="2011-04-05" version="1">MQGITKRFGVVEANQNIDFYLKPGEIHALLGENGAGKTTLMRILYGLYRADEGEIRVAGKVATIHSPKDAIQLGIGMVTQHFTLVPPLSVVENVALGQEGGTTLDLVQMRQRVVDAAKRFGIEVKPDALVRHLSVGERQRVEILKSLYRNARVLILDEPTAVLVPQEVEALFETLNKLRESGMALVFISHKLNEVMELCDRITVLRDGKKIGTVLRGETNEAELAHMMVGRETFGVVRPAERRGGEVRLRLEKVNALDKKGLPALKNVSLEVRAGEILGIAGISGNGQSELAQVLSGMLKPVSGTVWVDGRDMTGASPADFAAANIGRVPEDRHSGVVGDLSVAENLVLEHLEEFSRNGMMDYSAVQKFAQQMIEDFQIKARPQDPIRTLSGGNMQKVLLARALAHKPRVLIVAQPTRGLDIGATDYVRGKLLEQREAGTAILMISEDLDEVLALSDRIAVMYEGRIVGVVSGRRATPEVLGMMMSGALEVDYAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZZ9</accession>
    <name>E8MZZ9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_03000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558731.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03000"/>
    <dbReference type="EnsemblBacteria" id="BAJ62334">
        <property type="protein sequence ID" value="BAJ62334"/>
        <property type="gene ID" value="ANT_03000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03000"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_0_0"/>
    <dbReference type="OMA" id="ASWRPGK"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="303" mass="32027" checksum="26365DBDFBCDD3BA" modified="2011-04-05" version="1">MEAFLVGLIAATLRVATPLILGTLGELFSERSGILNLGIEGTMFLGAFTGFAVAYTTGSLWLGLLAAVIAGVLAGLLMGLLTVTLGVNQHVSGLGITLLTTGISLFLYRVIFGERSVQPSIATFTKVSPFGDTPILGPIFEQYLLTYIAIALVPLVWWVLYRTSFGLHLRAVGENPEAADAAGINVFRIRYLALAIGGGLMAAGGAFLSLAQLGSFIFGIIAGRGWVCIALIIFANWLPSRVLWGALLFGGVSALQLRLQSTGAQLPYELFLALPYLVTILALVLAGRSATAPAALLKPYRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N083</accession>
    <name>E8N083_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26060"/>
    <dbReference type="EnsemblBacteria" id="BAJ64632">
        <property type="protein sequence ID" value="BAJ64632"/>
        <property type="gene ID" value="ANT_26060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26060"/>
    <dbReference type="eggNOG" id="COG5433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379975_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="94" mass="10872" checksum="8E60082D9A94485B" modified="2011-04-05" version="1">MLLIVLAKIYGEERPSGIAECAKHRTEMLVEWLKLKRNSMLHHSTYRRILAEVVNVEELEHIQHIYLSGEKSFGTQVLVSIDGKVLRRTLDDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0F3</accession>
    <name>E8N0F3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ordered locus">ANT_26760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561054.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64702">
        <property type="protein sequence ID" value="BAJ64702"/>
        <property type="gene ID" value="ANT_26760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26760"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_0"/>
    <dbReference type="OMA" id="VIFMEDI"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="187" mass="21717" checksum="205D5237262069D4" modified="2011-04-05" version="1">MGLPFHFRYDFLDRVLITPEQIEQRVAELGDQITRDYQDSEKLMLLGLLRGSVMFITDLMRHIRRPLTMDFMAVSSYSGTESTGFVRIDHDHKASIAGWDVILVDDIVDSGYTLWMVRKLLLDRNPRSLKICALLDKPERHKYPIPIDYCGFTIPDEFVVGYGLDIDEKGRNLPYIASVDLKKYRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0G3</accession>
    <name>E8N0G3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_26860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26860"/>
    <dbReference type="EnsemblBacteria" id="BAJ64712">
        <property type="protein sequence ID" value="BAJ64712"/>
        <property type="gene ID" value="ANT_26860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26860"/>
    <dbReference type="HOGENOM" id="CLU_1313299_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="DUF4203"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="PTHR31247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="DUF4203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4203" evidence="6">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="209" mass="22032" checksum="A318D9769269EC25" modified="2011-04-05" version="1">MITPIGMISIVVGIIVCFSGYSMFRSMLPLWGFILGGAAAMYLAPLVIKVPEAQRLWLDIGSFVVGGVLGAVLASPLYYVTIFASGAAMGALSGMVFGAYLQISGGEISVRALRQLAGMTFPPRIETAVQVFLMVALGLIIGAAALSFQKFMITASTAFLGSAAVVSGFTGTITQALQGNPSQGVWMIVGWLLLGMLGMFIQFRMRDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P3</accession>
    <name>E8N0P3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558834.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04040"/>
    <dbReference type="EnsemblBacteria" id="BAJ62438">
        <property type="protein sequence ID" value="BAJ62438"/>
        <property type="gene ID" value="ANT_04040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04040"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_0"/>
    <dbReference type="OMA" id="NQFLAGR"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005345654" evidence="1">
        <location>
            <begin position="23"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="426" mass="46938" checksum="6ADCB7DB8A7DB865" modified="2011-04-05" version="1">MKRTLFSLILVLTIVLTACAQAGGTPAPSGGAAEIRFMAWGDPAELEVWKQIVADFEKENPNVKVNVEVSDWDSYWTKLKTLLAANTPPDIFAIDAPLYKDYQSRGVLLNLKPYLDANPGLLDGLYPVTLKAYETPEGYFGLPRDFQTIVVFYNKDMFNAAGIPYPQQGWTYDDLREIARKLTKDTNGDGKVDQYGFYADLWDMELIWGEGIWAHGGDVISADYTKTLIGTPEARKAWQLFHDMIFVDGSWPDANTAAQYGGDPFLAGVAAMTTIGHWAIPGYAEASFKWDVAPMPAGPAGQATSVNSAGFVVAKATKYPQESFNFIKFVLSEKGQTRLAELGFACPVLKSVAESPAFLEQEVKVNHQVFLDSLAFARMKPSFKGYEEWSSVIGDGMSVVWTGEAELDATLDEVVKQADEVLAKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q6</accession>
    <name>E8N0Q6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558847.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04170"/>
    <dbReference type="EnsemblBacteria" id="BAJ62451">
        <property type="protein sequence ID" value="BAJ62451"/>
        <property type="gene ID" value="ANT_04170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04170"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_35_1_0"/>
    <dbReference type="OMA" id="FVEKPPY"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="157" mass="17844" checksum="A6C7EA108CC9C140" modified="2011-04-05" version="1">MEITIRPATHEDAPLLADWHVRMFIELLEEEGQAINPQEMLVLNAVTQQYLATRLAQDKAAAWLLLENQQPVACAAVSILPCVPAPGRLDMEYPLLHSVFTLPEHRRKGYARRLVEQALEWCRQRGFSSVDLHASRAGEPLYRALGFHPTHEMRLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Q8</accession>
    <name>E8N0Q8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_04190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558849.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04190"/>
    <dbReference type="EnsemblBacteria" id="BAJ62453">
        <property type="protein sequence ID" value="BAJ62453"/>
        <property type="gene ID" value="ANT_04190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04190"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_1_0"/>
    <dbReference type="OMA" id="QWEAGYS"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="61"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="30437" checksum="C097AC66800827C7" modified="2011-04-05" version="1">MSTSTPAEVDPHLPTIRGNENVFRWDAGWLLVLAASALLAILVLVVGNPFDRIFRFVLDGLRVTVMVTLVTFGLVLVVGIIGALGRLTHIAPLRGLATLYVEVVRGIPLLVQLYFWYYAFPSIVRDLGTQWNVESMKNFVANPYVMAIAGLTLCYGAYMTEVYRAGIQSIPKGQMEAARSLGMTYFQAMRYIILPQAIRVILPPVGNEFITLLKDSSLVSAVAVADLTRRGREFQAITPLPLHIYLMIGLMYLIMTLLSARVVAMIEARMSKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V7</accession>
    <name>E8N0V7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558898.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04680"/>
    <dbReference type="EnsemblBacteria" id="BAJ62502">
        <property type="protein sequence ID" value="BAJ62502"/>
        <property type="gene ID" value="ANT_04680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04680"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123922_3_1_0"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="133" mass="15503" checksum="6C821E90520E6D4A" modified="2011-04-05" version="1">MESKIPPAFADLVSREKKALAYLALVRRDGSPQVTPVWFDFDGTYFIFNTARGRVKDRILRRHPKVAFVIQDPDNPYRYLQVSGRVVDEDENNAVEQIRDLCEKYHGHRYFKIAEGETRVTYRVLPERVQGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N107</accession>
    <name>E8N107_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_05180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558948.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05180"/>
    <dbReference type="EnsemblBacteria" id="BAJ62552">
        <property type="protein sequence ID" value="BAJ62552"/>
        <property type="gene ID" value="ANT_05180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05180"/>
    <dbReference type="HOGENOM" id="CLU_2068206_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="118" mass="13577" checksum="69C5D6D21C26A65C" modified="2011-04-05" version="1">MPITVNQLKNVNELVEYLNDLEAKIRVLEDENTALRSAMEEVSNSNRNVLNLLRQEWPRTGLVSRSFWIRALTVYGHFFVIQLIVTAFLFVGYLIFIAPVITRFINEVLPTLLPGMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N116</accession>
    <name>E8N116_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transport protein SCO1/SenC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_05270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558957.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05270"/>
    <dbReference type="EnsemblBacteria" id="BAJ62561">
        <property type="protein sequence ID" value="BAJ62561"/>
        <property type="gene ID" value="ANT_05270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05270"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_3_0_0"/>
    <dbReference type="OMA" id="FELNGWM"/>
    <dbReference type="OrthoDB" id="1994201at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="193" mass="21277" checksum="7CB7C9E65F421E47" modified="2011-04-05" version="1">MRKYAFWLGLGVFIALLAVAGLALAQPYRLRGSIIDPPQPAPAIALNGFDLSAQRGKVALLFFGYTTCPDVCPATLGEMKQVLQRLGTQAQNVQVVFVTVDPQRDTPEKIQKYTTAFDPRIVGVTGTEEDLQPIWQAYGVYREIRQGGTAAGYLVDHSARVYLIDPEGFLRATYPFGTPVEDLLSDVRFLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N138</accession>
    <name>E8N138_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_27550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27550"/>
    <dbReference type="EnsemblBacteria" id="BAJ64781">
        <property type="protein sequence ID" value="BAJ64781"/>
        <property type="gene ID" value="ANT_27550"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27550"/>
    <dbReference type="eggNOG" id="COG5032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085318_0_0_0"/>
    <dbReference type="OMA" id="WPAIPWP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022292">
        <property type="entry name" value="CHP03843"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03843">
        <property type="entry name" value="TIGR03843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="254" mass="29324" checksum="CB231ED65D6711AB" modified="2011-04-05" version="1">MSVLYPCWYTTINSEMDKQAILTLLSEGEMKVEGQFLAGSNYTFLVVVHWQDEDYPAVYKPVRGEQPLWDFPERTLAHREVAAYLVSEALGWDLVPPTVYRRRAPLGAGSVQWFVEHDPEHHFFHFTPEEKQRLRPVALFDLLTNNADRKGGHILMDAQGHIWLIDQGLCFHVEEKLRTVVWDFAGEPIPEDLLADLQAFVQRLETDEDLSASLGEHLSRAEIRALLRRGKRLLQEKVFPSPPSTRRPYPWPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1A9</accession>
    <name>E8N1A9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561198.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28260"/>
    <dbReference type="EnsemblBacteria" id="BAJ64852">
        <property type="protein sequence ID" value="BAJ64852"/>
        <property type="gene ID" value="ANT_28260"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28260"/>
    <dbReference type="eggNOG" id="ENOG5032VHB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149376_1_1_0"/>
    <dbReference type="OMA" id="RILMFIW"/>
    <dbReference type="OrthoDB" id="2089363at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021214">
        <property type="entry name" value="DUF2568"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10823">
        <property type="entry name" value="DUF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="119" mass="13124" checksum="B9A7928DD89B3C4F" modified="2011-04-05" version="1">MSSHPINAGLRFFLEIAALVSLGMWGWQKGEGWLRFLFAIGLPLAAAILWATFRVPNDPGNAPVAIPGILRLALEAGLFTFAVWGLHATGRTPWAWGLGIVVALHYITSYDRILWLIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1B2</accession>
    <name>E8N1B2_ANATU</name>
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        <submittedName>
            <fullName evidence="8">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_28290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28290"/>
    <dbReference type="EnsemblBacteria" id="BAJ64855">
        <property type="protein sequence ID" value="BAJ64855"/>
        <property type="gene ID" value="ANT_28290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28290"/>
    <dbReference type="eggNOG" id="COG0471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_6_1_0"/>
    <dbReference type="OMA" id="RCIDADE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="230"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="319"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="611" mass="66387" checksum="3FBFD64B05134B85" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C4</accession>
    <name>E8N1C4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">ANT_28410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561212.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28410"/>
    <dbReference type="EnsemblBacteria" id="BAJ64867">
        <property type="protein sequence ID" value="BAJ64867"/>
        <property type="gene ID" value="ANT_28410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28410"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_0_0_0"/>
    <dbReference type="OMA" id="FIRLECY"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="349" mass="39497" checksum="E76BAD04ABF3616D" modified="2011-04-05" version="1">MAIIQHLIVDEYGTFIGKHSERLIVFKGEEKRLQAPLLHLESVVIANLGVSISADAVQVCTERGIPIFFISSIGEPYASLYSAGLTGTVATRRAQLEAYRDRRGLELALALALGKIQNQSNFLRYMSKYRKESAPALYEELRRRSAEVLEVYRELERLRSAEAFQQGTWSIEDLREVMMALEGRAARHYWEAIALTVPEKYNFPGRVGRGAADPLNAALNYGYGILYGQVERAIVLAGLDPYAGFLHVDRPGKPSLTLDFIEEFRPTVVDRTIIGLANHSVDFEQDEKNLLTQDTRRMIAEKVLERLDTPIPFEGKRYPIRGIIQMQARHMATFLRGERAAYVPSQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1D4</accession>
    <name>E8N1D4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_28510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561222.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28510"/>
    <dbReference type="EnsemblBacteria" id="BAJ64877">
        <property type="protein sequence ID" value="BAJ64877"/>
        <property type="gene ID" value="ANT_28510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28510"/>
    <dbReference type="eggNOG" id="COG1336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047795_0_0_0"/>
    <dbReference type="OMA" id="FAWITCP"/>
    <dbReference type="OrthoDB" id="972874at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013410">
        <property type="entry name" value="CRISPR-assoc_RAMP_Cmr4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36700">
        <property type="entry name" value="PTHR36700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02580">
        <property type="entry name" value="cas_RAMP_Cmr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="301" mass="32858" checksum="9815823213759EBB" modified="2011-04-05" version="1">MFKARRLLFFYVETPLHVGAGRASANVDLPIQRERVTQYPMVQASSLKGALRAEFCQKHGIKDNSPEVEAVFGKAGGTGDNWAGAVSAGDARILLFPVRSLAGVFAWVTSLHALESFRRAADLVGQPISWTLPQGMPDTNTAWVGSKPQVSAQGKVVLEEFSFNAQPKAEVDAIAKWLAEHALPQGAAFQYWRDTLPARLCILHEDAFRDFCLYGTEVQTHIRIDPDKKTVAEGALWTAESLPADSLLYAPLMAMDVRNGKDSKNADAVLKEFDFLQDGHIQLGGDETTGQGWVAVKVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1E2</accession>
    <name>E8N1E2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_28590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561230.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64885">
        <property type="protein sequence ID" value="BAJ64885"/>
        <property type="gene ID" value="ANT_28590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28590"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="OMA" id="YKIVYFF"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="313" mass="35130" checksum="502A1A6DE56D55C6" modified="2011-04-05" version="1">MGVSLNRNGEGALPYRSTARTQQLWTVLIFLLPTFVLFIVFVVYPVAQSFYYSMFNWKGFGPAVDFVGLDNFKRILTDKAFMKAVGNTLTIVVLSLFIQLPLSLGLALMVGRDLPGKRFFRTIFFVPYVFSEVITAIMWMGLFNPDPDRGLINAIIILMGGKPQPWLGSPQMVMGCIFVVLTWKYFGFHMLLYMAGLQNIPREIEEAALIDGCTTGQMITHITLPLLWGTIRTSIYLSVLGALQQFGLIWVMTKGGPVNASEVMSTYMYRYSFIRFWLGYGSAVAIVILLISLAFSIAYLRLVRQQDVLGGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-02-10" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F8</accession>
    <name>E8N1F8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/hydrogen exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_28750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28750"/>
    <dbReference type="EnsemblBacteria" id="BAJ64901">
        <property type="protein sequence ID" value="BAJ64901"/>
        <property type="gene ID" value="ANT_28750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28750"/>
    <dbReference type="eggNOG" id="COG3263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472320_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="101"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="183" mass="19790" checksum="E7994807A2240313" modified="2011-04-05" version="1">MLCAAALILLARPLSVFVSLLFSSLNLREKTFVSWVGLRGAVPIVLATFPLLAGVSHADLMFNVIFFVVLTSVLLQGTTIPIMARWLKVDAPETPRRVYPIEYTPVGGFKSELKELTLSPESPAVGKAIVELGLPDEFLIILIAREKDFILPSGGTVLQGGDTLLVLADKASFEAVQAKICPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1J7</accession>
    <name>E8N1J7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05680"/>
    <dbReference type="EnsemblBacteria" id="BAJ62602">
        <property type="protein sequence ID" value="BAJ62602"/>
        <property type="gene ID" value="ANT_05680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05680"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488896_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="557" mass="63725" checksum="EFB5A822EDAF5431" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R0</accession>
    <name>E8N1R0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative polysaccharide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_06310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559060.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06310"/>
    <dbReference type="EnsemblBacteria" id="BAJ62665">
        <property type="protein sequence ID" value="BAJ62665"/>
        <property type="gene ID" value="ANT_06310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06310"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_101_1_0"/>
    <dbReference type="OMA" id="DARIVWH"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="35"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="418" mass="46939" checksum="E6FEED724CBEAE13" modified="2011-04-05" version="1">MSDWAIRVEKIGKQYRIGTLNSQRYQTLRDAITGLFDRSARNVVSGRIWALKDVSFEVRQGQVLGIIGRNGAGKSTLLKILSRVTQPTEGFGEIRGRVGSLLEVGTGFHPELTGRENIYLNGAILGMKRREIERKFDEIVEFAEVGAFIDTPVKRYSSGMYLRLAFAVAAHLEPEILVVDEVLAVGDAEFQRKCLGKMSDVAQEGRTVLFVSHNMSAILRLTQETLVIEKGRLKMRAPTPEAVDYYLSQGYSQEGQRTWDADEIPPEAAPFRPCAVRIVNAEGKVTETVRSTEPFHIEVEYALDAPITGLRVGVYLMSMRGEYIFTSFDTDDPQRFERYPVRQTGVYVSRCTVPADLLNEGRYAVGINASSFRVRRYFQDDQALSFTVDATGAPGTHWTEARLGPLRPRLDWKIEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1U6</accession>
    <name>E8N1U6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_06670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559096.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06670"/>
    <dbReference type="EnsemblBacteria" id="BAJ62701">
        <property type="protein sequence ID" value="BAJ62701"/>
        <property type="gene ID" value="ANT_06670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06670"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_0"/>
    <dbReference type="OMA" id="DWMMMCE"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005674959" evidence="2">
        <location>
            <begin position="25"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="124"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="638" mass="70668" checksum="816C26E7900DBB2B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1V7</accession>
    <name>E8N1V7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_06780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559106.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06780"/>
    <dbReference type="EnsemblBacteria" id="BAJ62712">
        <property type="protein sequence ID" value="BAJ62712"/>
        <property type="gene ID" value="ANT_06780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06780"/>
    <dbReference type="eggNOG" id="COG2229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077970_2_0_0"/>
    <dbReference type="OMA" id="DRFDFMW"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="20199" checksum="963477694E047F18" modified="2011-04-05" version="1">MQTVKMVVTGPFSAGKTAFIRSVSEIDVVSTERKISSEAERVKETTTVAMDFGRITVDDDLVLYLFGTPGQRRFDFMWEILSEGMLGFIVMVDSTRPETFREARSILQTFRAYAPTPYVVAANKQDLPDAWDLEDMRLALRLEPKAKLLPCVAHKKESVKNVLLELLYSILAEMEEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X3</accession>
    <name>E8N1X3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative esterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_28940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28940"/>
    <dbReference type="EnsemblBacteria" id="BAJ64920">
        <property type="protein sequence ID" value="BAJ64920"/>
        <property type="gene ID" value="ANT_28940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28940"/>
    <dbReference type="eggNOG" id="COG2382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923299_0_0_0"/>
    <dbReference type="OMA" id="PFRFDCG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228573" evidence="2">
        <location>
            <begin position="22"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="301" mass="33969" checksum="516B63F04F317610" modified="2011-04-05" version="1">MRIARWGMFFLFLLTACGEVAVPSADLPVLASATPSPALPAQTDAPVLPSPTLQPSATPVPSPTPCPQDEGHFEEGSLDSRLMKRALTYRIYLPPCYNRQAGATYPLLILLHGQSYRADQWERLGMGTAADALITAGQVRPFVILLPEEWNTSIVQRESAYGRALIEELLPYVEEQYALCRERVCRAIGGLSRGAAWALDLAFEHPDLFSAVGAHSLAPYYGQETHLRRIILDHPETLFPRVYLDTGRADRYRTEAISVEVMFTRLGVPHEWYFNEGLHEEPYWQAHVPAYLRWYTRDWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Y7</accession>
    <name>E8N1Y7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64934">
        <property type="protein sequence ID" value="BAJ64934"/>
        <property type="gene ID" value="ANT_29080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29080"/>
    <dbReference type="eggNOG" id="ENOG5030TQD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131757_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="26549" checksum="450DF93C211E3839" modified="2011-04-05" version="1">MTSMGVVTALLLTGTLAGMVLLAGLSRLRTRMWSAAGVVLPLLPMAYLLNRFIRAPFFDYLGTQANLPPFLDLEMPWWFLGLWWLFPPLLEEWAKALVFLFPPASRLLQDARPAFLGGMLAGLAYALGETVYVHWATPDPSVVNLAGYAAERAAFTLLHGALTAQVALGLARGRGGALRAFLAAAGLHALAILGIVLMQVGLIEPLAALIALWAGTLLALGWGIWQARRMFRERDAESLDNLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Z4</accession>
    <name>E8N1Z4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561285.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29150"/>
    <dbReference type="EnsemblBacteria" id="BAJ64941">
        <property type="protein sequence ID" value="BAJ64941"/>
        <property type="gene ID" value="ANT_29150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29150"/>
    <dbReference type="eggNOG" id="COG4552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1451622_0_0_0"/>
    <dbReference type="OrthoDB" id="1481620at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="186" mass="21178" checksum="B2D6DEF37BA070F2" modified="2011-04-05" version="1">MPPHLVIHTQENLPPALHWQALSFKRMVWASAFQGEHRFDADWYPPGYEVLHFSIVEGENLISHCELVRLTFGLENEVYQIYGLGAVMTFPPYRGEGFARRVVEAATRHILTSDVDLGLLFCRRELIPLYASCGWEAQSPTALTVLGSTLRSEDAEMVRMALFVSEKGKAAREAFLNDPLTIEWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N222</accession>
    <name>E8N222_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561313.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29430"/>
    <dbReference type="EnsemblBacteria" id="BAJ64969">
        <property type="protein sequence ID" value="BAJ64969"/>
        <property type="gene ID" value="ANT_29430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29430"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_753639_0_0_0"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_C554" evidence="1">
        <location>
            <begin position="57"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="367" mass="40521" checksum="220421C7ADC28513" modified="2011-04-05" version="1">MAPLEPWEKVLVSADFKKTTHGRFTCVQCHGGTQSPDKETAHTGLIANPSAEGSGRCDMCHKDITAEYPNSLHASLAGYAVSMQARSVPENHLALEQAFNNHCSKCHTSCGDCHITQPQNVGGGLLEGHNFVKTPPMTRTCTACHGTRVGNEYLGKNEGIPGDVHFRQGRMNCVSCHEGATLHTTPEDARGNRYWGEQTPACEDCHQQVGASGDTIPQHVLHKDKLQCQVCHSVQYTSCDGCHVAISDKTNLPFYKTEGTYLTFFIGRNATDNPNRPYEYVVVRHVPASPTSYQYYGENLLPNFNLRPTWMYTTPHNIQRKTPQNSSCNSCHGNSDLFLTADKVKPEELEANRRVIVEDIPAPIPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N249</accession>
    <name>E8N249_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_29700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29700"/>
    <dbReference type="EnsemblBacteria" id="BAJ64996">
        <property type="protein sequence ID" value="BAJ64996"/>
        <property type="gene ID" value="ANT_29700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29700"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_0_0_0"/>
    <dbReference type="OMA" id="QAFWRVA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="347"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="545" mass="58923" checksum="92A3350931F6E569" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2A8</accession>
    <name>E8N2A8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4037 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30290"/>
    <dbReference type="EnsemblBacteria" id="BAJ65055">
        <property type="protein sequence ID" value="BAJ65055"/>
        <property type="gene ID" value="ANT_30290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30290"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056336_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025117">
        <property type="entry name" value="DUF4037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13228">
        <property type="entry name" value="DUF4037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4037" evidence="1">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="390" mass="44634" checksum="8C25D80AF4C020CD" modified="2011-04-05" version="1">MSADSLPQYYSESAGGEIMGEPFDPATVAFVPGLELSRQYYFKAVRPILNDVFPKLRHSAALVGYGSDVVGLDTERSRDHMWGPRMVLFVEPSFNPAERGFLYQALRQRLPVEFMGYPTHFGPPDEEGVRLMRKIKEGPVDHLIEITTLPEYFSKEIGWDTQAPLTVQDWLTFSEHKLLSLTSGGVWHDDLGLETLRQQLMYYPRDVWMYLLAAQWMKLGQEEAFVGRTAEVNDDLGSRIITARLVQIVIGLAFLIERKYAPYSKWFGSAFERLNMAPRLQPYLAGALRANNFPERESHLCQAYSICTEEFNRLGLIEPVETRPTFFHNRPYRVIHGDWIAHKIRAAIPDERIRNLPNYLGSVNQFSGSVDLVSETEVCLSLKYLYNPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2I0</accession>
    <name>E8N2I0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559179.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62786">
        <property type="protein sequence ID" value="BAJ62786"/>
        <property type="gene ID" value="ANT_07520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07520"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_3_0"/>
    <dbReference type="OMA" id="HTRREGT"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="15079" checksum="85098638AA2D1E72" modified="2011-04-05" version="1">MNNNSYIPTANLSGLRCEDNSLHEEAIHQAQANLIDGLTATRLAAAFQALSDPTRVRLISALLEQELCVHDLAAVLGMSQSATSHQLRVLRALGLVRTRKEGRIVYYALDDEHIRELFQRGLEHIRHQQNFQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K7</accession>
    <name>E8N2K7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07790"/>
    <dbReference type="EnsemblBacteria" id="BAJ62813">
        <property type="protein sequence ID" value="BAJ62813"/>
        <property type="gene ID" value="ANT_07790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07790"/>
    <dbReference type="HOGENOM" id="CLU_1912692_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="132" mass="15024" checksum="F822F8BAEFEAEE5F" modified="2011-04-05" version="1">MRFHRLVLALVLLALAWMGLGRALWAWRDRDLLARYGAQPGWEYLMVTGGIWALLALSAAGLTLWGNPRWFRIAFLEVMIWTGLYWADLLFFSRSGEALLNLGFTLGVSIAGLFYAGFALDFLPALFLRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2L4</accession>
    <name>E8N2L4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559213.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07860"/>
    <dbReference type="EnsemblBacteria" id="BAJ62820">
        <property type="protein sequence ID" value="BAJ62820"/>
        <property type="gene ID" value="ANT_07860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07860"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833259_0_0_0"/>
    <dbReference type="OMA" id="PRWEVIL"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="107"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="333" mass="36786" checksum="4E7AB1A6E6F30361" modified="2011-04-05" version="1">MNDTPIHPNDYSSLDPLAETQPSPSLDYDPLAAYQPIRIPKEARPRQKARRRKSGGCLGCLGVFGVFLALIIGAMVFFAFLPGKTRVLILGIDLNSDRAPAGSFLGRSDTIVILQADPLKPQVSMLSIPRDLWVNIPGVGENRINTAHFFAEANQEGTGAQATIQTIETNFGIRIPYYVRLRFEGFSQIVDAMGGVDITLEEPMAGLDAGRHHLNGKEALAFARSRKGADDFFRMQQGQLVVMAAMKKMLNPLTWWRLPVIVPAFFSAVDTNLPVWQMPRIGLAVLRVGVDNLDHRTITREMVQPFVTEGGAQVLGPRWEVILPLVQEMFGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2M9</accession>
    <name>E8N2M9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559227.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62835">
        <property type="protein sequence ID" value="BAJ62835"/>
        <property type="gene ID" value="ANT_08010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08010"/>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050189_0_0_0"/>
    <dbReference type="OMA" id="WADENYG"/>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="439" mass="47457" checksum="DB0773361A4E02CB" modified="2011-04-05" version="1">MNPSPIISLPWGKDTLTLELPPTWHLLGVLGPSPLPGVSSPKEETARSLQEVIGSPPLAELARDAKRVVVVTDDGSRPTPVAQIFPAVMAELERGGISAEQVTVIPALGVHRPMQAEEVAQRIGGEWMSRVQWESHDCDTPERLAFLGTTSRGTPVYINKTVAEADLIVSIGCIEPHIIASFGGGYKNLIPGVAGRATIAHNHGLNCHPDTFNMVGQPIEHNPMRLDLEEGAQMLKGRVFIVNAVLNSALEVVKVVSGHPIHAHRAGTQVSAQIYGVPIPAQADVLITASYPMDQDLRQGVKALANTIRALKPGGVMITTIRAEEGVGVFGLANRKLPVGRKVLKLLAPLLLPRVPKLKLKGMGEEDKFFLYFALQAMLHGTLLLYAPTIPQEIHERLPFVSFVPNVQTALELAKKRFPEKASVLVFPQGGMTYPILPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N359</accession>
    <name>E8N359_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit K</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">nuoK</name>
        <name evidence="6" type="ordered locus">ANT_08390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559265.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08390"/>
    <dbReference type="EnsemblBacteria" id="BAJ62873">
        <property type="protein sequence ID" value="BAJ62873"/>
        <property type="gene ID" value="ANT_08390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08390"/>
    <dbReference type="eggNOG" id="COG0713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_0_0_0"/>
    <dbReference type="OMA" id="NFVAFSY"/>
    <dbReference type="OrthoDB" id="2081663at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="100" mass="11031" checksum="ECBBD05786E2684C" modified="2011-04-05" version="1">MVPASYYLILSVVLFTLGALGVLLRRNALVVFMSLEMMFNASNLAFITFARMYNALSAQVVVFFVMTVAAAEVAIGLALMVEIFRTKRSVDLDQMNTLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N373</accession>
    <name>E8N373_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559279.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08530"/>
    <dbReference type="EnsemblBacteria" id="BAJ62887">
        <property type="protein sequence ID" value="BAJ62887"/>
        <property type="gene ID" value="ANT_08530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08530"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_0"/>
    <dbReference type="OMA" id="THANITF"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="33941" checksum="4F77A07FB0450BD8" modified="2011-04-05" version="1">MRFLITGAAGFLGSALANQLVREGHSVRGLDDLSTGSPDALLPDVHLTRGDINDRPKLWTLLQDVDCVYHLAARVSVPESVLYPREYNHVNVGGTVTLMEAMRDVGVRRVVLISSGAVYGEQEHQPLSEDARPQPRSPYAVSKLSAEYYVNTIGRLWGIETVILRVFNAYGPGQHLPPVHAPVIPHFLKQAWSNGTIVVHGDGNQTRDYVFVDDVVNAMVAAASATQINQRIINVGSGTETSVRELVQLILEVTGSHPQVIYNPRNDGGVQRMCADITLARELLGYQPTVGLRQGLQLTLEKDARIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N376</accession>
    <name>E8N376_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenite export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsB</name>
        <name evidence="5" type="ordered locus">ANT_08560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559282.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62890">
        <property type="protein sequence ID" value="BAJ62890"/>
        <property type="gene ID" value="ANT_08560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08560"/>
    <dbReference type="eggNOG" id="COG0798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_0"/>
    <dbReference type="OMA" id="CTAMVLM"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="360" mass="39856" checksum="EC559225C75454ED" modified="2011-04-05" version="1">MEKPLTQRLSVLDRYLTLWIFLAMALGVGIGYFLPGVEEFVNRFSVGTTNIPIAIGLILMMYPPLAKVHYNELGDVFRNRKVLTLSLIQNWVIGPILMFLLAVIFLRNYPHYMVGLIMIGLARCIAMVIVWNELAKGDTEYAAGLVAFNSIFQVLFYSVYAYVFITVLPTWFGLQGSVVDVTIGEIARSVFIYLGIPFIAGFITNMVLRRMKGEDWYYHRFIPRISPITLAALLFTIVVMFSLKGNLIVTIPGDVLRIAVPLLLYFVLMFLVSFGMGKLVGADYSKTTTLSFTAASNNFELAIAVAVAVFGINSGEAFTAVIGPLVEVPVMIGLVNVAFWLQKRLFAGKASVTAEATPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N387</accession>
    <name>E8N387_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ligT</name>
        <name evidence="4" type="ordered locus">ANT_08670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559293.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08670"/>
    <dbReference type="EnsemblBacteria" id="BAJ62901">
        <property type="protein sequence ID" value="BAJ62901"/>
        <property type="gene ID" value="ANT_08670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08670"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_0_1_0"/>
    <dbReference type="OMA" id="HITLRFL"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="102"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="192" mass="21593" checksum="FF482B4C5432FA7E" modified="2011-04-05" version="1">MNAIRAFIAIDLPEDLRHKLGEIMDSLKKKTPRAVRWVPPQNIHLTLKFLGNVSPNNLNTLTQMLRQEALRHSPMQFSVGSLGAFPSKQRPRVIWVGVHAPPALMDLQRCVDQETAVLGYPVEEREYSPHLTLGRVSQNVTALELRQIADALFDTHVGDLGVVRVTEIRLYRSDLQPGGSVYTPLFTAPLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3B5</accession>
    <name>E8N3B5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_08950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559321.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08950"/>
    <dbReference type="EnsemblBacteria" id="BAJ62929">
        <property type="protein sequence ID" value="BAJ62929"/>
        <property type="gene ID" value="ANT_08950"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08950"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_354762_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="561"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="423"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="791" mass="87988" checksum="CF4399B368DED2C8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F2</accession>
    <name>E8N3F2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_09320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559357.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09320"/>
    <dbReference type="EnsemblBacteria" id="BAJ62966">
        <property type="protein sequence ID" value="BAJ62966"/>
        <property type="gene ID" value="ANT_09320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09320"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="IEHNIAG"/>
    <dbReference type="OrthoDB" id="1819694at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="254"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="471" mass="51422" checksum="FB4BBA25CB95024D" modified="2011-04-05" version="1">MKTLRARMILSHLLPIVIVVPLIGIALIYFLETRVLLPGLLKAYSGNAALVAEITRDQLRIWSDPVYAQTILAQVSPRLSARVMLFSASGRLLASTDPADLKNLTDYLIHPALQEAQQGKIVQKVYYNRQLRGEALDLWEPVYDSQFGVVIGVVRITYLFEDIGAQFVQQRLLIAGVLLLGLAVGALIGWRLAVGLERPLSRATEAVRRLAEGEPSEIVPTGGPQEIRVLVEAVNVLAERLKNLESARRQLLANLVHELGRPLGALRSAVQALLNGAVNDHVLSGELLNGMENELVRLQSLLGELTHLYDQVLGDLELERKPVDLKAWLGELIAPWQVNAAEQGVRWETVIPDELPSLSIDPVRMGQALGNLLSNAVKFTPAGGLIRLEVSQTPAEVRICVRDTGAGIPPDELEKIFTPFYRGTQGKRFVEGMGLGLSIARDVVKAHGGRIDVESIVGQGSAFTIVLPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3F5</accession>
    <name>E8N3F5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase for insertion sequence element</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559360.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09350"/>
    <dbReference type="EnsemblBacteria" id="BAJ62969">
        <property type="protein sequence ID" value="BAJ62969"/>
        <property type="gene ID" value="ANT_09350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09350"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_728910_0_0_0"/>
    <dbReference type="OrthoDB" id="607377at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="136"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="379" mass="43687" checksum="1FC72C095443EBF7" modified="2011-04-05" version="1">MDKYIPMRSFMEEFFDDEITATKAAEIGQAMLVARSLRLTEIAGKMRGGSAASYKRIQRFLQKVDPRAMLWRLFCEQAEYVIGAPTEIERPQAWKTEYVGTLKDGKTRGFWVLLLATPYRGRALPCGLLTYSSKTIAADRSSRNVNHVRAFAGLKDLLGERPLVLDREFSYLELLLNLVEEGVNFVIRLNLGHHPPRFWDAEGREVVLSLAPGEKVIHPSVWYKGKVCVNLIGVWKKGLAEPLWVMSNLEPERAWQVYLWRMKIEETFRDLKGLLGMTRLMNKRQENMEKMVAMLLLVYAIALLIGEGLRDRLYGSPNQLQENVDVVLHKTGKKWRRYSGLFILLKQKWWLPPREWQSIVKEALASFVAIVRPTVLTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3P9</accession>
    <name>E8N3P9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsK</name>
        <name evidence="9" type="ordered locus">ANT_10290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559454.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63063">
        <property type="protein sequence ID" value="BAJ63063"/>
        <property type="gene ID" value="ANT_10290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10290"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_0"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="134" mass="14143" checksum="263854A1D005695C" modified="2011-04-05" version="1">MAQNVRSARRGGSAKKVKRTLTSGQIHIYASFNNTIVTVTDQQGNTVCWGSSGSAGFKGSRKSTPFAARLAAEQAVKAAMAMGLQEADLIVKGPGPGRESAIRAVQAMGVRVRSIADVTPVPHNGCRPPKKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S3</accession>
    <name>E8N3S3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ordered locus">ANT_10530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559477.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10530"/>
    <dbReference type="EnsemblBacteria" id="BAJ63087">
        <property type="protein sequence ID" value="BAJ63087"/>
        <property type="gene ID" value="ANT_10530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10530"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_2_0_0"/>
    <dbReference type="OMA" id="ALIFRQY"/>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ63087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="78" mass="7980" checksum="FF18AC2955D71881" modified="2011-04-05" version="1">MTGDIIEAAKFIGAGLSMIGALGAGIGIGLSVQGALEGMARNPDTYGNLLTNMILGIAFSEAIAIYCLVIAFLMLFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3S8</accession>
    <name>E8N3S8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">rpsO</name>
        <name evidence="8" type="ordered locus">ANT_10580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559482.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10580"/>
    <dbReference type="EnsemblBacteria" id="BAJ63092">
        <property type="protein sequence ID" value="BAJ63092"/>
        <property type="gene ID" value="ANT_10580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10580"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_0"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="90" mass="10741" checksum="07FE2AAC310EE49F" modified="2011-04-05" version="1">MTLTKEQKDSLINQFQRHEGDTGSPEVQVALLTERINQLTNHLRMHKHDESSRRGLLMLVGQRRRLLAYLRKKDYRRYVALAERLNLRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3W7</accession>
    <name>E8N3W7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_10970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559521.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63131">
        <property type="protein sequence ID" value="BAJ63131"/>
        <property type="gene ID" value="ANT_10970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10970"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="CHFPEDP"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="34"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="356" mass="39755" checksum="F0F070BC9B8753C1" modified="2011-04-05" version="1">MSEAATVATPSTYNPPKDGNLLLDVRGLKKYFPIQKGLLRRVVGYVKAVDDVTFFVREGETLGLVGESGCGKTTAGRTIIRLYEPTGGEVYFKSRVLSPSGEPQWVNMAALDRAQMKLVRQEIAMIFQDPINSLNPRMSVGDIVAEPMVIHGKYGPDSEQVIISLLERVGLRADHLRRYPHEFSGGQRQRIGIARALSMNPRLVICDEPVSALDVSIQAQTLNLLQDLQKDFNLSYIFVAHDLSVVQHISDRVAVMYVGKMVEMADAEELYNAPLHPYTEALMSAVPKPDPLYKSERIIMQGDVADPSNPPSGCYFHPRCRYAVDICKTKTPEFRELKPDHFVACHRAEELKLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Y7</accession>
    <name>E8N3Y7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559540.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11170"/>
    <dbReference type="EnsemblBacteria" id="BAJ63151">
        <property type="protein sequence ID" value="BAJ63151"/>
        <property type="gene ID" value="ANT_11170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11170"/>
    <dbReference type="HOGENOM" id="CLU_1575260_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="169" mass="19522" checksum="D67F56C6668A5CAD" modified="2011-04-05" version="1">MEMELLPYGVVLIALLGLALLVRSLGVLRAFQQQIRQMFSRARIQWITWGMLVFPLLVSGGVWFWLSSQEKVALLIKWAYVFFMLGTWLTLSLAMFLLYLLYRLEQKPSVAMLSSPVLIVPLVAYFSPFQRFFEVFGMYPQLAIPCGVVMFIVGVLVIFEIRRELLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3Z1</accession>
    <name>E8N3Z1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formimidoyltransferase-cyclodeaminase</fullName>
            <ecNumber evidence="6">2.1.2.5</ecNumber>
            <ecNumber evidence="7">4.3.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Formiminotransferase-cyclodeaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ordered locus">ANT_11210</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the formiminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="6"/>
    <dbReference type="EC" id="4.3.1.4" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559544.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11210"/>
    <dbReference type="EnsemblBacteria" id="BAJ63155">
        <property type="protein sequence ID" value="BAJ63155"/>
        <property type="gene ID" value="ANT_11210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11210"/>
    <dbReference type="eggNOG" id="COG3404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040037_1_0_0"/>
    <dbReference type="OMA" id="VGQPECV"/>
    <dbReference type="OrthoDB" id="351626at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030412">
        <property type="term" value="F:formimidoyltetrahydrofolate cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02971">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="SSF55116"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="15 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_N" evidence="22">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="FTCD" evidence="21">
        <location>
            <begin position="182"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="BAJ63155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="513" mass="56163" checksum="649606947EFAB139" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N402</accession>
    <name>E8N402_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559554.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11320"/>
    <dbReference type="EnsemblBacteria" id="BAJ63166">
        <property type="protein sequence ID" value="BAJ63166"/>
        <property type="gene ID" value="ANT_11320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11320"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796762_0_0_0"/>
    <dbReference type="OMA" id="HPRRAFT"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="356" mass="40555" checksum="BF31A5B47E6131A6" modified="2011-04-05" version="1">MTVELVVNLHMHTPYSDGFGTHKQICQTALRHDIDVVIVTDHNVWVRDLEGYITEGKRRVMLLIGEEVHDRNRIPQKNHLLVIGANRELAGFADNPQRLIENATQAGGLTFIAHPVDPELLIFGEQDISWENWEVFGFTGIELWNGFSELKARVKNRWQGIFYGLFPNFYPAGPLPETLKRWDDLLINRPEKCVAIGGSDAHALPMKFAFLRRVIFPYAFHFQGVNTHLLLEEDLSGDFLRDRQKVLGALVAGHAFIGYDRPASTRGFRFYAHGSEGTALMGDDLRLGTGVTFQVRLPQRAECVLIRDGEPVQVWEDQEACTYMTTKPGIYRVESYLPYLGKKRGWIFSNPIYVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N403</accession>
    <name>E8N403_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_11330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559555.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11330"/>
    <dbReference type="EnsemblBacteria" id="BAJ63167">
        <property type="protein sequence ID" value="BAJ63167"/>
        <property type="gene ID" value="ANT_11330"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11330"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_1_0_0"/>
    <dbReference type="OMA" id="PYDYVEH"/>
    <dbReference type="OrthoDB" id="1503081at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="168" mass="18364" checksum="F7C745DE87363C49" modified="2011-04-05" version="1">MAVVNNVTRMLDAKKIPYQAFELPAEKLGAEETARILGVSPSVVFKTIVVKRFTPGTKPILAVIPGDCELDEKKLAALLGEKKVQVPSQREAEEMTGLLAGGISPLALINRGFQIWIDEKAMRLDFIHVSGGQRGLNIRLKPQDLVRLTQARLGDLSSSKGFQEGDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N409</accession>
    <name>E8N409_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="3">MTA phosphorylase</shortName>
            <shortName evidence="3">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mtaP</name>
        <name evidence="3" type="synonym">mtnP</name>
        <name evidence="5" type="ordered locus">ANT_11390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559561.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11390"/>
    <dbReference type="EnsemblBacteria" id="BAJ63173">
        <property type="protein sequence ID" value="BAJ63173"/>
        <property type="gene ID" value="ANT_11390"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11390"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_0"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="8"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="56"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="289" mass="31347" checksum="77D600A61D39D2D8" modified="2011-04-05" version="1">MKEHAPVLGVIGGSGLYQMSSLTDVEQVEVETPFGKPSSPVVIGTLEGKRVAFVARHGIGHVYSPSEVNYRANIYALKMLGVKQVISISACGSLREDYAPGHIVIPDQIFDFTHKRARSFFGDGLVAHVGVADPVCKDLSRQVYEAVLQAGGTAHLGGTLITIEGPRFSTRAESNAYRSWGMSIIGMTASPEVFLAREAEMCYAIMAHVTDYDVWHVSEAPVTVEMVIRTLLQNTQIAQQAVQALMPHVPVACQSGCQHALADALITAKDRIPQETREKLSLLVGRYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8N474</accession>
    <name>E8N474_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63238">
        <property type="protein sequence ID" value="BAJ63238"/>
        <property type="gene ID" value="ANT_12040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12040"/>
    <dbReference type="HOGENOM" id="CLU_2821694_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="66" mass="7285" checksum="DD66CB10BD4A13DA" modified="2011-04-05" version="1">MEEVHSSQSSQVEDEVLKPVLTSLDFQRQGDWGSTCPKCHQGVLDYDGMLNLTCPVCGYQEGGCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N493</accession>
    <name>E8N493_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">ANT_12230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559645.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12230"/>
    <dbReference type="EnsemblBacteria" id="BAJ63257">
        <property type="protein sequence ID" value="BAJ63257"/>
        <property type="gene ID" value="ANT_12230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12230"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_1_0_0"/>
    <dbReference type="OMA" id="WHMQAML"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09721">
        <property type="entry name" value="Cas1_I-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019856">
        <property type="entry name" value="CRISPR-assoc_Cas1_DVULG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03640">
        <property type="entry name" value="cas1_DVULG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="343" mass="38851" checksum="B77E3A435100CE12" modified="2011-04-05" version="1">MKTLSNVLYITSPEVYLSLDGENVVVRKDEHTSTRLPLHNLENIVCFNWQGVSPALMGACAERGIGLAFLSPNGRFLGRVTGKVYGNVLLRKKQYLISEHESQCVPIASSFLIGKIYNSRKVIERALRDHGLLVDKDTLGRASAFLKEILKGLTTCKHIPELMAFEGSAAKIYFSVFDQLILQQKEDFHFEERSRRPPLDNMNSLLSFLYTLLTNEAMSALEAVGLDPYVGFLHADRPGRPSLALDLMEELRPVFADRLALSLVNRKQITGKGFTQKESGGILMDDDTRKTVITAWQERKKEEIEHPYLKERIPFGLIPHVQALLLARYLRGDLDAYPPFFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4A5</accession>
    <name>E8N4A5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12350"/>
    <dbReference type="EnsemblBacteria" id="BAJ63269">
        <property type="protein sequence ID" value="BAJ63269"/>
        <property type="gene ID" value="ANT_12350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12350"/>
    <dbReference type="HOGENOM" id="CLU_1544460_0_0_0"/>
    <dbReference type="OrthoDB" id="2123329at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="19533" checksum="1F700C21345CA2A0" modified="2011-04-05" version="1">MQAHCRYGPAKAFLHAADLYPGDHGTVRGRYAYSAWLYVKFDKLKYFCWVAPSVVNIEGDINKVYLTEPKLPGPSVLYGAPENVRVQREGDRVVVTWDRVAMTEDDDRGYMLDVFVCQNQRLIWYPVSLPNQYETSAAFTDEPGCSAPSGGVLYTVEKHGYSHPTKIPWIPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B3</accession>
    <name>E8N4B3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argH</name>
        <name evidence="8" type="ordered locus">ANT_12430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63277">
        <property type="protein sequence ID" value="BAJ63277"/>
        <property type="gene ID" value="ANT_12430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12430"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_0"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="13"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="371"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="481" mass="53213" checksum="D610B557FBE8DF38" modified="2011-04-05" version="1">MQGEKDMSKLWGGRFSSGLDPIAWEYNASISFDWRLAEVDIRGSIAWAKALMKAGVISLDEQQQIVKGLTDVLSEVRSGKFKHEPTDEDVHTAIERRLIELTGPVGGKLHTGRSRNDQIATDFTLWLVEAIDRIDAFVKLVQSALVDRAENDFGIILPGYTHFQQSQPILLSHWWLSHFWPLARDRQRLGQLRERAAVLPLGSGALAGTPYPVDRKFLANQLGLKAITPNSIDAVSNRDSAAEFLFVSTMIALHLSRLAEMLILYTSAEFGFIELSDAYSTGSSLMPQKKNPDTLELTRGKAGTMIGRLAGLLSVLKGLPSAYDKDLQEDKVPVFEASDTLCLMLPVVAGVLRTLEVHPEKMHKALDPAILATDLADYLVRKGVPFRQAHAMVGQIVRRAHDLNLLLNQLPLKEFQKVSPLFEEDVHGVFDFQASIAHRNVPGGTSPAAVQIQLQQARQFLEQHKIRSALPPETPRGGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4D1</accession>
    <name>E8N4D1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559683.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12610"/>
    <dbReference type="EnsemblBacteria" id="BAJ63295">
        <property type="protein sequence ID" value="BAJ63295"/>
        <property type="gene ID" value="ANT_12610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12610"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130332_2_3_0"/>
    <dbReference type="OMA" id="YCIDVAN"/>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="90" mass="10280" checksum="6FB276256EE74E10" modified="2011-04-05" version="1">MHDRSEAIHRLKIVEGHIRGIQKMLEEDAYCIDVIRQIQAVQSSLNKVSTLLLEQHLNSCVITAVQGEDPKERERVLKEISDVFEAATRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4K9</accession>
    <name>E8N4K9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_13410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63373">
        <property type="protein sequence ID" value="BAJ63373"/>
        <property type="gene ID" value="ANT_13410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13410"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025379_2_0_0"/>
    <dbReference type="OMA" id="RAWMGSI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="257"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="472" mass="51868" checksum="157C8A22F9FDC63B" modified="2011-04-05" version="1">MSMKRQTSQISWEKIKTSMQLITAGGSWSAQFPDQVQHNLRMFFFDGVFAASQDAIHVTYLTLYVLALGATKAQIGLMSALGSIGAMLLLLPGAILAEKLPSRKWLVVWTGGGISRLMLLGFAILPFFLSGEPAVVIAIAMKVVMDGFGNLSMPAWTSLTADIVPLAWRGRYFGTRNMFMGIANMLVTFIAGQIIVLSMTPVVGYQRVYFIALMFGIASSVFFASIREPRSGQMVSQSSLEVYKPGVLLQGLKQDRNFLAFCISQMVWNFSVNIAGPFFSVYQVEVLNSTAAIIGIQSIIASVAGLPAQRLFGALNDRWGARKVLLLTGFLIPFMPFVWLFVRSPWHPTPINIWAGFMWAGYNLATFNFLLALSTPQTRARYSALYQIAVTLSLAAGSAFGGFLVQHVGYPAIFISSGLGRFLSVFLLWRFVKAPEEHALSASSLLVVEESSGDFDHFDKDNNTCEDDSKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Q3</accession>
    <name>E8N4Q3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">OmpR family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_13890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559801.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13890"/>
    <dbReference type="EnsemblBacteria" id="BAJ63417">
        <property type="protein sequence ID" value="BAJ63417"/>
        <property type="gene ID" value="ANT_13890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13890"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_0"/>
    <dbReference type="OMA" id="DNVWGYQ"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="239" mass="27016" checksum="34D32CDB1A566EAF" modified="2011-04-05" version="1">MAATHILVVDDEPRYQHLLRVNLEAAGYLVSTASNGEEALELISSRQPDLVILDVMMPHLDGFSTCERIRQFSSVPIIMLTAKGEEQDRVKGLNVGADDYVVKPFSATELIARVRAVLRRAQTAEAVTQNRYFTHGNLKIDFARAEVWKDDKPVFLSATEYRLLIQFAHNMGRVLSPEELLTAVWGTQYKEDKEILWVSIARLRQKLEDNPHNPVHIVTRSGLGYLMPPMEKDSSETGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T1</accession>
    <name>E8N4T1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpt</name>
        <name evidence="4" type="ordered locus">ANT_14170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559827.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14170"/>
    <dbReference type="EnsemblBacteria" id="BAJ63445">
        <property type="protein sequence ID" value="BAJ63445"/>
        <property type="gene ID" value="ANT_14170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14170"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_0"/>
    <dbReference type="OMA" id="IEFMAVS"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="191" mass="21993" checksum="0E051804983B997F" modified="2011-04-05" version="1">MWDYREFLGEVLIDSDTLQRRIQELGEQISKDYEGKKLLLVCILRGGVMFLTDLMRSIRIPHAIEFMAVSSYGVGGRHSSGQVRITFDLNTDISEWDVILVEDIIDSGHTLHSVLELLSIRQPKSLSVCALLDKSERREVEIPLKYIGFEIPNKFVFGYGLDIDDFYRNLPFIGVVNLEKYNALIHQQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T4</accession>
    <name>E8N4T4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_14200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559830.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14200"/>
    <dbReference type="EnsemblBacteria" id="BAJ63448">
        <property type="protein sequence ID" value="BAJ63448"/>
        <property type="gene ID" value="ANT_14200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14200"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155828_0_0_0"/>
    <dbReference type="OrthoDB" id="2082361at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="120" mass="13223" checksum="397A5C7BE4BD99D6" modified="2011-04-05" version="1">MYMVMFVLDDSTLLDDVLDAWYSAGITGATIFESNGIFRQRAKRFNLPVRYALPHVTAKIEANYTLMAIVPDEEAVQACLQASEKVVGDLSQPYTGVFASWPLSFVKGVRIENQTPSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4V4</accession>
    <name>E8N4V4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent NADPH reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559850.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63468">
        <property type="protein sequence ID" value="BAJ63468"/>
        <property type="gene ID" value="ANT_14400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14400"/>
    <dbReference type="eggNOG" id="COG2085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_1_0_0"/>
    <dbReference type="OMA" id="IDTDVMV"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="225" mass="24071" checksum="9B68355431FA2066" modified="2011-04-05" version="1">MESPEQTIAIIGGTGKEGKGLAYRWAKAGYTVLIGSRVREKALATVAELRERLGEAVRMEGMTNQEAAEKADIVVLTVPYAAHQETLLTIKDQVQGKILIDVTVPLMPPKVTRVHIPPAGSAAQEAQNILGPDVQVVSAFQNISYEHLLNDHEIECDVLVCGGTRAARAEVIKLVEAAGLTGWDAGPIENSIVAEGLTSILIGINKQYGVESAGIRITGVQRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y6</accession>
    <name>E8N4Y6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_14720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559882.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14720"/>
    <dbReference type="EnsemblBacteria" id="BAJ63500">
        <property type="protein sequence ID" value="BAJ63500"/>
        <property type="gene ID" value="ANT_14720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14720"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_0"/>
    <dbReference type="OMA" id="DTRFMSE"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="164"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="272"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="416"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ63500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="473" mass="51765" checksum="D6465D5E81231D8E" modified="2011-04-05" version="1">MSHTIRFGTDGWRGVIAEDYTFANVRCATQGYASYMIRHGKAGATFVIGHDKRFHSENFALAAAEVMAGNGLKVLLTDGATPTPVIAFSVVHHKAAGAINITASHNPPTDNGFKVRNEFGGAIDPEGLKEIESLIPEDESEVKRMPASEAEAKGLIQRFDPAPAYIEHLKELIDVEPIKQAGLKIVVDCMWGNGAGWFPRILSGGKTEIIEIHNERNPIFPEMKRPEPIPPNINVGLKKTVDSGADVLLITDGDADRVGVGDEKGNFINQLQVYALLALYLLEVRGERGAIVKTLSTTSMLEKLGKMYNIPVYETGVGFKYVAPKMLETNAMIGGEESGGYAFRGNVPERDGILAGLYILDMMVKLQRKPSELIDLLFSKVGPHFYDRIDRTFTGERSAREQAILAANPTTIGGLKVTGLNTTDGFKFSLEDGGWLLIRFSGTEPIMRVYCETTHKDRVPYILKDGLKIAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N508</accession>
    <name>E8N508_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559904.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14940"/>
    <dbReference type="EnsemblBacteria" id="BAJ63522">
        <property type="protein sequence ID" value="BAJ63522"/>
        <property type="gene ID" value="ANT_14940"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14940"/>
    <dbReference type="eggNOG" id="ENOG5032UAK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1431855_0_0_0"/>
    <dbReference type="OMA" id="ENCCIVY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="189" mass="21371" checksum="8940BCA19C3C2BF0" modified="2011-04-05" version="1">MIHQWLTLLNKYASGKILILLFMALIPFNLLIFPAMQMELSRRALTSDAHMLDVQIGYTAEQALDEISQLGVQGKQWYRLITWTADLVYPALYSTFFALLLAFLLRVVSVTDSRFSLVPLVPFLMALMDYGENIAITVALSAFSQPSEGILALASVLSALKWACGIVILLFVVLLLFYLLFRMLKKMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N578</accession>
    <name>E8N578_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_15640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15640"/>
    <dbReference type="EnsemblBacteria" id="BAJ63592">
        <property type="protein sequence ID" value="BAJ63592"/>
        <property type="gene ID" value="ANT_15640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15640"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_1_0"/>
    <dbReference type="OMA" id="PYKIAYA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="284" mass="32675" checksum="AC324560ACD7F0FD" modified="2011-04-05" version="1">MLMIANFSYRSHHSIIEKIDPRARWIFALCMLFSIVLFWDLRILSVFFALSLAQFFASKVTWKETKRAWIFILVLSSMMIFVNTVITGVETVGGTVRGGTPLFSIKFPFLDSFYVLTVERLWFALTQYLRIISIASLFIILPFTMDPRLYGTTFRGLGFPDKLAYTMDLAFRFIPTIARDFNVTLDAQRARGFELDKGNINILQRIRRMAPLMVPVTMNSILAGEDIANAMDLRCFGLKKRSWVESLRYKAGDLALIIFSIFILGISLYLRFGLKIGDFWMPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5A3</accession>
    <name>E8N5A3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">lepA</name>
        <name evidence="7" type="ordered locus">ANT_15910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63617">
        <property type="protein sequence ID" value="BAJ63617"/>
        <property type="gene ID" value="ANT_15910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15910"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_0"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="604" mass="67756" checksum="E40AB5496C16466F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D3</accession>
    <name>E8N5D3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">ldh</name>
        <name evidence="12" type="ordered locus">ANT_16210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560027.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16210"/>
    <dbReference type="EnsemblBacteria" id="BAJ63647">
        <property type="protein sequence ID" value="BAJ63647"/>
        <property type="gene ID" value="ANT_16210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16210"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_1_1_0"/>
    <dbReference type="OMA" id="CYIIVLT"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="10">
        <location>
            <begin position="10"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="11">
        <location>
            <begin position="151"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="6">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="319" mass="34825" checksum="70BA3A5D09793044" modified="2011-04-05" version="1">MLPEGIHRPVKVGIVGTGNVGATFAYALLLSGLATEIILIDNNRARAEGEAMDLNHAAPLARPARVFAGDYSDLAGAVVTVVTAGSAQRPGETRLDLAGRNAEIFRSIIPKITQFNPSGIILIATNPVDILSYVAWKLSGLPHNQVIGSGTILDTARFRYLLSEYFQVDPRSVHAYIIGEHGDSEVPVWSLANIAGMRLPVFCTRNNFGCIDHELEEIFTQTRDAAYHIIERKGATYYAIGAGLLRIVEAIIRDQSTVLSVSNLIQNYYGINDVYLSLPCVIDRGGVERVIYLELNDEEAIGLRKSASVLRKMIEDLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5F8</accession>
    <name>E8N5F8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
            <ecNumber evidence="2">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560051.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63672">
        <property type="protein sequence ID" value="BAJ63672"/>
        <property type="gene ID" value="ANT_16460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16460"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023673_0_0_0"/>
    <dbReference type="OMA" id="EAMHIGF"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="257"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="492" mass="55770" checksum="18D11BEAA016C54E" modified="2011-04-05" version="1">MLQRLYFRARFTLVIIQSNEEERVLHSIRSACEKNQRACLTWDVADFFQWLTSSNQPLPTARDALTALEQIEKFDPGNQTVFVLKDFHEVWNNPQIKRKLKNLAQRLKYTRKTILITTHTSRVPEELKDETVILEFPLPKAEELQDVLNTLSQNSGVRTHLTPLGKEKLIQAALGLTTSQAQRVFARAIVTDGILDDRDIDLVTEEKRQIIRESEALEFYPATYTLADIGGLKALKEWLRMRELAFSQRAREYGLPVPKGIALIGIPGTGKSLTAKMIGGLWHLPLLRLDVGALFGSLVGESEERTRRALHLAETIAPCILWIDEMEKALAHGGLDSGTSTRVFGNILTWMQEKSAPVFVVATANDISSLPPELLRRGRFDEIFFLDLPNHEERMEIFSVHLQKRKRLPEDYDLELLADRSEGYVGAEIEQAVIDAMYIGFNDGEREFTTEDILTALKRQVPLSVSQREIVAALRAWLREGRAQSASGSLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H3</accession>
    <name>E8N5H3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">clpP</name>
        <name evidence="4" type="ordered locus">ANT_16610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560066.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16610"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="BAJ63687">
        <property type="protein sequence ID" value="BAJ63687"/>
        <property type="gene ID" value="ANT_16610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16610"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_0"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="201" mass="22310" checksum="EEC4E82AEFB3BA13" modified="2011-04-05" version="1">MSIPDFRSVIPMVIESSARGERAYDIYSLLLKERIVFVGTPIDDQIANLIVAQLLFLSREDPEKDIQMYINCPGGLIYAGMAIYDTMQMIPNRISTVAVGVTASFGTVLLAAGSKGQRYALPHATIHMHQPLGGAQGQASDIEIQAREILRLKSQLNQILSQCTGQPMDVIERDTERDFYMDSYQAVEYGLVDKVLEPPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P1</accession>
    <name>E8N5P1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PGA_cap domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_17290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17290"/>
    <dbReference type="EnsemblBacteria" id="BAJ63755">
        <property type="protein sequence ID" value="BAJ63755"/>
        <property type="gene ID" value="ANT_17290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17290"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495809_0_0_0"/>
    <dbReference type="OMA" id="MNDIDIG"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="262"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="562" mass="63390" checksum="A72679E4158BD0C6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R6</accession>
    <name>E8N5R6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">META domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_17540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560158.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17540"/>
    <dbReference type="EnsemblBacteria" id="BAJ63780">
        <property type="protein sequence ID" value="BAJ63780"/>
        <property type="gene ID" value="ANT_17540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17540"/>
    <dbReference type="eggNOG" id="COG3187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075808_6_1_0"/>
    <dbReference type="OrthoDB" id="2029962at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228653" description="META domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="137" mass="15016" checksum="CE693653A0551337" modified="2011-04-05" version="1">MRKATALLITILAIVILSACAGTAEEENPLKGTVWSLETIGESAAYPGVDVIVDFGDGEVRGNTGCNDFNGQYKVKGDTIEFKDVSMTMMACQNPSLRAQENAFLNALQLARSYHTDGNMLELLDEYGETLMILRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5Y9</accession>
    <name>E8N5Y9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_18270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18270"/>
    <dbReference type="EnsemblBacteria" id="BAJ63853">
        <property type="protein sequence ID" value="BAJ63853"/>
        <property type="gene ID" value="ANT_18270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18270"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1881435_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="135" mass="16488" checksum="53C8D59313CF21C5" modified="2011-04-05" version="1">MIDFLENEALESEKKFPQFVHPIEEVFARILDFYGIQWEYEPRTFPLRWDDEGNVLEAFTPDFYLPEQNLFVELTTLRPRLTTKKNRKLKRLKELYPDINIKLFKRRELRNMMLRFGLREEVERIIGTDAQEMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N603</accession>
    <name>E8N603_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18410"/>
    <dbReference type="EnsemblBacteria" id="BAJ63867">
        <property type="protein sequence ID" value="BAJ63867"/>
        <property type="gene ID" value="ANT_18410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18410"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073076_1_0_0"/>
    <dbReference type="OMA" id="EHCGRIL"/>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="236" mass="26889" checksum="E4DCE40C673739BE" modified="2011-04-05" version="1">MVSMNQSAHLFRLQQIDSQLDQVNARLKQIEKLLSEDTRILNARKKAEEIHRELEKSRLRLHNAEELVRQQNIKIEQTEATLYSGSVRNPKELQDLEKELASLKKHLGTLEDQQLEAMMTVEQNEVFANQAQAEYQKILGEVISEQAGLSGEREQLEKTKIRLETERQALCTSVKAENLQIYEQLRLQKKGVAVTQVEDNSCSACGATIRASEVQAARMQPHLIFCNSCGRILYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N610</accession>
    <name>E8N610_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiol-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560251.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63874">
        <property type="protein sequence ID" value="BAJ63874"/>
        <property type="gene ID" value="ANT_18480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18480"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_2_0"/>
    <dbReference type="OMA" id="INYFASW"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="178" mass="19923" checksum="9B9D42A6E9E173D3" modified="2011-04-05" version="1">MKWKNFLFLAAGLAIGLILGMAVFISTPSKSSAEKISPPATGKPMADFELVDLNGKVHRLSDFRGKPVVLNFWATWCPPCNEEMPVFEAYHKQLGDEVVFIGINYMEDVATVQNFVEANQITFQVLLDPAGKASDKYYVQAYPTTFFIDKDGVLRAQRIGVLTPRMLENYLRAVEITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N624</accession>
    <name>E8N624_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560265.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18620"/>
    <dbReference type="EnsemblBacteria" id="BAJ63888">
        <property type="protein sequence ID" value="BAJ63888"/>
        <property type="gene ID" value="ANT_18620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18620"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="OMA" id="HIELYQM"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="323" mass="36248" checksum="AE86247CEC842399" modified="2011-04-05" version="1">MQYVHLGRSGLLVSRLCLGTMNFGPLTSEEESFQIMDRALDLGINFFDTANVYGWKLGEGVTENIIGKWFAQGGGRREKVVIATKVFGKMGEWPNESKLSALHIRKACEDSLRRLRTDHIDLYQMHHIDPETPWEEIWQAMEVLVQQGKVIYVGSSNFGGWHIANAMETAKQRHFMGLVSEQSLYNLAARTIELEVIPASRHYGIGIIPWSPLAGGLLGGVLQKINEGRRASEGVQKQLEKHRAQVEQYEAFCREIGESPADVALAWLLHNPAVTAPIIGPRTIEQLEGSLRALEIHLTEEMLKRLDEIWPGPGGEAPWAYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N692</accession>
    <name>E8N692_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560329.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19300"/>
    <dbReference type="EnsemblBacteria" id="BAJ63956">
        <property type="protein sequence ID" value="BAJ63956"/>
        <property type="gene ID" value="ANT_19300"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19300"/>
    <dbReference type="HOGENOM" id="CLU_367882_0_0_0"/>
    <dbReference type="OrthoDB" id="2162894at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="757" mass="84747" checksum="9B9441A32DFD1F00" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B9</accession>
    <name>E8N6B9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19570"/>
    <dbReference type="EnsemblBacteria" id="BAJ63983">
        <property type="protein sequence ID" value="BAJ63983"/>
        <property type="gene ID" value="ANT_19570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19570"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563471_0_0_0"/>
    <dbReference type="OMA" id="GDNHTFE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021280">
        <property type="entry name" value="DUF2723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11028">
        <property type="entry name" value="DUF2723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="496" mass="55396" checksum="00531E8E2785CC25" modified="2011-04-05" version="1">MVRYSSMKRFLSPFLIATLVGGIFYLPLLPERITWQNQGADGGDFLAAILTQGVPHPSGYPLYLVLGAVFQSFPVHTPYWRGALLSALCMAMAAGLLALWVEKVVFKAKPWAGAVGVFSAFLWLSTRLVWSQALIVEVHGLHALVVMIWVWWISALMGETLLSIKTLCLLGGMAGLGVGNHLSIVWLLPLVLWAGIGYGRRTSWRFVFLQAICFGSGLLIYGILPLRAQAYPPVNWGGASDWQGFLWLVTGKIYQGMLFNVDGEQFLSRLSAFADLWLKDFSVLGVLLALGGVLIAYPTRVGKILLWIFLAFASFSLGYAAEDSQVYLIPAWMALSMATGIGLMEIKNWKWKTFPVGWVLISLFLFWVVWCIPATLREVDVRYKGDAADFAERTLQSLPSNAVIVTIRDQDTFPLWYYHFGLKQRPDVRIVVLPLTPFAWYRQSLQKAYPDLHYPSTDSGGEWGEKLLALNSDRAICQTKVDLHPSIIIAYECQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D3</accession>
    <name>E8N6D3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11 12">Uridine kinase</fullName>
            <ecNumber evidence="7 11 12">2.7.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytidine monophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Uridine monophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">udk</name>
        <name evidence="14" type="ordered locus">ANT_19710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + cytidine = ADP + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11 12">
            <text>ATP + uridine = ADP + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 11 12">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11 12">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 11 12">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7 11 12"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560370.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63997">
        <property type="protein sequence ID" value="BAJ63997"/>
        <property type="gene ID" value="ANT_19710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19710"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_1_2_0"/>
    <dbReference type="OMA" id="TTLKPMH"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00551">
        <property type="entry name" value="Uridine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026008">
        <property type="entry name" value="Uridine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="13">
        <location>
            <begin position="9"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ63997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="214" mass="24656" checksum="B87FDC14A611655D" modified="2011-04-05" version="1">MQGRLTPLVIGIAGGTGSGKTTVVKSIIERVGSHRIACLSHDAYYRDLTHLSLEERQRVNFDHPDSLETDLLIEHIQQLKQWKPVRMPVYDFARHTRTEQTILVEPRRIILVDGILIFYEPALRALFDVKLFVDTDPDIRFIRRLQRDIVERGRTTDSVIRQYLETVRPMHLEFVEPTKRYADVIIPEGGMNIVALDMVIARIEKLLGEESSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXG2</accession>
    <name>E8MXG2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_20170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560413.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20170"/>
    <dbReference type="EnsemblBacteria" id="BAJ64043">
        <property type="protein sequence ID" value="BAJ64043"/>
        <property type="gene ID" value="ANT_20170"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20170"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_274820_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1164" mass="126701" checksum="3CC9043D9716D464" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ6</accession>
    <name>E8MXQ6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21110"/>
    <dbReference type="EnsemblBacteria" id="BAJ64137">
        <property type="protein sequence ID" value="BAJ64137"/>
        <property type="gene ID" value="ANT_21110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21110"/>
    <dbReference type="HOGENOM" id="CLU_3264882_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="41" mass="4624" checksum="146700382425B296" modified="2011-04-05" version="1">MKSQKFSFLQNEDWLSVVIAFGLILLSVLGWIGKQGLPIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXQ8</accession>
    <name>E8MXQ8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_21130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560509.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21130"/>
    <dbReference type="EnsemblBacteria" id="BAJ64139">
        <property type="protein sequence ID" value="BAJ64139"/>
        <property type="gene ID" value="ANT_21130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21130"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_18_2_0"/>
    <dbReference type="OMA" id="KYGVMST"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005243">
        <property type="entry name" value="Redox_disulphide_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36450">
        <property type="entry name" value="PTHR36450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037031">
        <property type="entry name" value="Redox_disulphide_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00412">
        <property type="entry name" value="redox_disulf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="80" mass="8632" checksum="AF7E2DBAB083C984" modified="2011-04-05" version="1">MLNIKILGSGCANCKRLEALARKVVGELGLEAEFEKVTDMNEIMKWPILSTPGLVVNGKVVSYGRIPSEAEIAGWLKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXT6</accession>
    <name>E8MXT6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xre family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21410"/>
    <dbReference type="EnsemblBacteria" id="BAJ64167">
        <property type="protein sequence ID" value="BAJ64167"/>
        <property type="gene ID" value="ANT_21410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21410"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144725_3_2_0"/>
    <dbReference type="OMA" id="ESMTQMN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="97" mass="11015" checksum="D2CB42CB15A8C110" modified="2011-04-05" version="1">MNNETFTELLSSVQEGADILRGRRPPSRVFDINFQDVKAIRERLGLSQRQFAALMGVSIDTLQNWEQNRRKPRGAARTLLLIAAKHPETILDILKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY08</accession>
    <name>E8MY08_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glycosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_22130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560608.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22130"/>
    <dbReference type="EnsemblBacteria" id="BAJ64239">
        <property type="protein sequence ID" value="BAJ64239"/>
        <property type="gene ID" value="ANT_22130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22130"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009024_1_0_0"/>
    <dbReference type="OMA" id="NEVVIGW"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="61"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_5_C" evidence="5">
        <location>
            <begin position="540"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="626" mass="72357" checksum="AB7541A3BAE8FFFC" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY70</accession>
    <name>E8MY70_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_22750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22750"/>
    <dbReference type="EnsemblBacteria" id="BAJ64301">
        <property type="protein sequence ID" value="BAJ64301"/>
        <property type="gene ID" value="ANT_22750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22750"/>
    <dbReference type="eggNOG" id="ENOG5032TTD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115719_3_0_0"/>
    <dbReference type="OMA" id="FGYCLGC"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4395" evidence="2">
        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="165" mass="18239" checksum="0651524A109380D4" modified="2011-04-05" version="1">MMNPLEPVDHSALKVNQLLIILLSLLAFILNVPLLVALVALLMLSASLLLKRAAFGWVYHLFLKPLGWIKPDLIPDHREPHLFAQGVGGTFLAIATVCLLSGWFVAGWILTWIVIVLAALNLFGGFCLGCAMYYWFHRLGIPGFTQSPPEGTLPGFRPRKEVNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD5</accession>
    <name>E8MYD5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62080">
        <property type="protein sequence ID" value="BAJ62080"/>
        <property type="gene ID" value="ANT_00460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00460"/>
    <dbReference type="HOGENOM" id="CLU_3179503_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="46" mass="5034" checksum="DB6DECB36F08D5DB" modified="2011-04-05" version="1">MGEWLAFIGLGLSSFPSGLSEFYPTSGAQAQKNSRRGRLKGKFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYD6</accession>
    <name>E8MYD6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558479.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00470"/>
    <dbReference type="EnsemblBacteria" id="BAJ62081">
        <property type="protein sequence ID" value="BAJ62081"/>
        <property type="gene ID" value="ANT_00470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00470"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093445_0_0_0"/>
    <dbReference type="OMA" id="PFETHGV"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="245" mass="27645" checksum="611CEC5C98F7941A" modified="2011-04-05" version="1">MNASHSPKAALRGEPSYVWRAGQERRLKMMLAAAGERIHGRVLVDGCGVGMYLARFVPLAQQAVGLDIEHERTVEAHQSAPQVVCGAGEALPFPENHFDFLLSHEVLEHVQDDARAIREMVRVLKPGGRIALFCPNRGYPFETHGIYWRGRYRFGNIPLVNYLPRRWRDRLAPHVRVYTAGDLQRLFAGLPVRVVQRTIVFGAYDNIIARRPALGKVLRAVLQALEATPLRIFGLSHFWVVEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYE1</accession>
    <name>E8MYE1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_00520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558484.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62086">
        <property type="protein sequence ID" value="BAJ62086"/>
        <property type="gene ID" value="ANT_00520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00520"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119948_0_0_0"/>
    <dbReference type="OMA" id="CGTPICP"/>
    <dbReference type="OrthoDB" id="1187884at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="174" mass="19452" checksum="2C1288212D090720" modified="2011-04-05" version="1">MSEMPSVPQPVCYRHPDRETLLRCSRCERYICTSCAVLTPTGYRCPECIRGQQKVYETTQWWDYPLAFFIAGVISLLGSWVAQFMGFFTIFIAPVAGFFIAEAVRWAVRKRRSRLLFRVTAVAAALGGLPIFIVMLVSLLMGGGVGGILSLVWSGLYMVLVTSSTYYRLSGIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYJ2</accession>
    <name>E8MYJ2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560695.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23020"/>
    <dbReference type="EnsemblBacteria" id="BAJ64328">
        <property type="protein sequence ID" value="BAJ64328"/>
        <property type="gene ID" value="ANT_23020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23020"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_424328_0_0_0"/>
    <dbReference type="OMA" id="EYWHFER"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="645" mass="72773" checksum="45B1E1B44F33F0DD" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYK4</accession>
    <name>E8MYK4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative glycosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_23140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23140"/>
    <dbReference type="EnsemblBacteria" id="BAJ64340">
        <property type="protein sequence ID" value="BAJ64340"/>
        <property type="gene ID" value="ANT_23140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23140"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642148_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="268"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="367"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="406" mass="45206" checksum="34B196C7E045FBB0" modified="2011-04-05" version="1">MNMRIMLVADGRSPITRRYLKVLLDLGVQVTLVSSFPCAPVEGVEGMYTLPVAFGRFAGTQSGAGLDQPYKANQGARRAVARFRKAFLSLRYWLGPLTLPFYSAHLRRIYREVQPDVVHALRIPFEGMMASGLPENATLLVSIWGNDLTLHAQGSIWMNLLTRRVLRRVNGLTADAYRDIRLARTMGFRSSFPSAVFPGAGGIDLQAFEHLKRAGSEPRSDPIPAGVPLVINPRGFRPGSVRNDVFFEAIPLVLQRYPKVAFICPAMAGQPEAEETVRRLGIQRQVVLLPYLPQENLWELFLRATVMVSISQHDGTPNSLLEAMVAGCFPVAGDIESIREWITPGVNGLLVQPNRADQAADAILMALENADLRLRAREANRKIIEERAEVGKVKQQILSFYQQFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYR5</accession>
    <name>E8MYR5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 11" type="primary">hisD</name>
        <name evidence="11" type="ordered locus">ANT_23750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560767.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23750"/>
    <dbReference type="EnsemblBacteria" id="BAJ64401">
        <property type="protein sequence ID" value="BAJ64401"/>
        <property type="gene ID" value="ANT_23750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23750"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_3_0"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ64401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="440" mass="47165" checksum="849511EF7819F13F" modified="2011-04-05" version="1">MLRKFSVDEARNAILKRIPLDEAEVSPLILDRITALFGEPLSPEQAVMRILRDVRRRGDAALQEWTQRLDGVSLTNFRVPKEEIRSALQTLSDVQLNALRLAAERIRRFHLAQPLTSWLTQSMGGTLGQLVRPIRRVGVYVPAGSAPLPSSVLMSVIPAQVAGVPEIVVVAPPMRSTGKVDPVILAACALCGVDEVYALGGAQAIAALAYGTESLPAVDKIFGPGNLFVTLAKKQVFGTVGIDGLAGPTETVVIADDSANPEWVAADLLAQAEHDPLASAILLTPSEPLIAQVQEAVSCQLQERQRAEIIRQSLEVRSGAVLTADLDEAVALANEYAPEHLCLSVTQPWALVPEITAAGGIFLGEHSFEVLGDYVAGPSHVMPTCRTARFASPLNVWDFVHLIHLVALDEATTKKIAPAAAIIAEREGLDAHAFSARLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX1</accession>
    <name>E8MYX1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560812.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24310"/>
    <dbReference type="EnsemblBacteria" id="BAJ64457">
        <property type="protein sequence ID" value="BAJ64457"/>
        <property type="gene ID" value="ANT_24310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24310"/>
    <dbReference type="HOGENOM" id="CLU_134960_0_1_0"/>
    <dbReference type="OrthoDB" id="1879806at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="133" mass="15332" checksum="A7C2A539A9A1DFB0" modified="2011-04-05" version="1">MNAKYLPVVGKIIRHARRVLRELGPGHAEMVYHRALLHELRSAGETVLYQPRLKVRYNGQAVGEVVPDLLVRKGNSTVLIECKLASQEFEQADFDQLRRYLRAYEGDAVGLLLGFGGERLEFRRVWLEKREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYZ4</accession>
    <name>E8MYZ4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative protoporphyrin oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_01030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01030"/>
    <dbReference type="EnsemblBacteria" id="BAJ62137">
        <property type="protein sequence ID" value="BAJ62137"/>
        <property type="gene ID" value="ANT_01030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01030"/>
    <dbReference type="eggNOG" id="COG4635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3094962_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="51" mass="6144" checksum="1DDB1E36CFA1025E" modified="2011-04-05" version="1">MFFAGKIDYYTLSFFDRLITRLVAKQSGQSKPVNDLRDWEKIRRWAEEVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ20</accession>
    <name>E8MZ20_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_01290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01290"/>
    <dbReference type="REBASE" id="32147">
        <property type="entry name" value="M.AthUNI1ORF1290P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62163">
        <property type="protein sequence ID" value="BAJ62163"/>
        <property type="gene ID" value="ANT_01290"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01290"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060286_0_0_0"/>
    <dbReference type="OMA" id="VFIGDMY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="162"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="35603" checksum="391798C4B8C3A6C0" modified="2011-04-05" version="1">MNDTYTGISLPLKVKEAQTLYRTKLSIGYTRTCSCPPNHLSCLSAKEWIKCQLGVWQFNYEGRDIRDKSIHPATFPISLSKKVISLFTHEGELVLDPFVGSGTTLVAARDLNRNAVGFDLQEKYIDLCAERLATNNLFNNAQQVAIHDDARNIPNYLEPEMVSLIWTSPPYANLLNRKRLNKSRRDRKNEQFGKIEQYSQDPSDLGTMPLEEYTRAMGEIFEKLLPLLKPRGHCVINVPDMWWEDKRITIHVSLIEELRQRGYELRNIIIWDRTNIVNKIGIFGWPSNYITMGTTFEYLLDFWRPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ40</accession>
    <name>E8MZ40_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_01490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01490"/>
    <dbReference type="EnsemblBacteria" id="BAJ62183">
        <property type="protein sequence ID" value="BAJ62183"/>
        <property type="gene ID" value="ANT_01490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01490"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_7_0"/>
    <dbReference type="OMA" id="LEYMRMA"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="173" mass="20326" checksum="AAC21463999F5561" modified="2011-04-05" version="1">MIGRVLFSRLIISWLNNFAKADMKKFPFPETLDFILHQVCHLHHHRVRQVFESLGLYRGQPPILRMLWDEEGLTHNELAARLNVTPATMSRTLQRMEKAGFLVRKPDPADQRVSRVYLTEHGRAVQEQVQQSIQRIEEETFAGFSAEELPVLRSFLERIRENLWRATGEKELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ76</accession>
    <name>E8MZ76_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">ANT_01850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_01850"/>
    <dbReference type="EnsemblBacteria" id="BAJ62219">
        <property type="protein sequence ID" value="BAJ62219"/>
        <property type="gene ID" value="ANT_01850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_01850"/>
    <dbReference type="eggNOG" id="COG5542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036370_3_1_0"/>
    <dbReference type="OMA" id="DGWWYQQ"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="394" mass="44854" checksum="9697D8FCEAFDFBF4" modified="2011-04-05" version="1">MGYNIPMRQKLSSWWNRLPESWRFVLPIWLGMRLLTAIIGIGVWKIRPLPPPVGMRFYEGLEPVYLGLRGMLIGVWQRWDTIFYQIIAEQGYSLTKISHFFPLYPLTARVTARLTGLETLEAMVLVSTLAYLAALVLLYVLLADTFDTTIARRGVLALAVFPSSFFLFALYPHGMELALILASVWLARKRRWLGCALTALLAGLTHSTALPLSLILLVEAVRFIRQQTHPWRWAVLSVAGMPALGIGLFWAWRIAQGFPSIPEVIAREFFRYPTPPWENLLKWLVLLPQHLPAPDWIINSVALILVVWSLLWGWKKIPASWLTYQVLVLLMTLGLGDARDPLYSLNRYILASFPLFVALGWWADTPLKRLLGFAVGVFGQLALLAFFLLWIFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ99</accession>
    <name>E8MZ99_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558640.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02080"/>
    <dbReference type="EnsemblBacteria" id="BAJ62242">
        <property type="protein sequence ID" value="BAJ62242"/>
        <property type="gene ID" value="ANT_02080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02080"/>
    <dbReference type="HOGENOM" id="CLU_2393441_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="93" mass="10149" checksum="AE742E16EDEBEC41" modified="2011-04-05" version="1">MVTSFQESNLTGPSRTRPEQELSRLLTAAVISPHFRRLLLSNPAQAIASGFGGEAFHLQGEEQQQLAAIQADDLADFALQVSALRLFSVTPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZA6</accession>
    <name>E8MZA6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_02150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02150"/>
    <dbReference type="EnsemblBacteria" id="BAJ62249">
        <property type="protein sequence ID" value="BAJ62249"/>
        <property type="gene ID" value="ANT_02150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02150"/>
    <dbReference type="HOGENOM" id="CLU_1912690_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="132" mass="14436" checksum="05309894DD9809C2" modified="2011-04-05" version="1">MIEEIEPNKDALRAASDGVVPGPNGEKMTIVNRYFPYHLGAVKTDGWAEANFRQPGLSWITCKSKGYNDRGQDSGWKETHGPFGGTSCGPTPKATIALALKPATYTSVTQAFWKWSTGEETSGEARQTHYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZB6</accession>
    <name>E8MZB6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">infB</name>
        <name evidence="10" type="ordered locus">ANT_02250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558657.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62259">
        <property type="protein sequence ID" value="BAJ62259"/>
        <property type="gene ID" value="ANT_02250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02250"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_1_0"/>
    <dbReference type="OMA" id="NRDNRTG"/>
    <dbReference type="OrthoDB" id="347113at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="97"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="7">
        <location>
            <begin position="100"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="152"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="593" mass="64519" checksum="B204E17FCE43C6D8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZC7</accession>
    <name>E8MZC7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A)</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cyclic oligoadenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_24490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated Cas10/Csm1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560830.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24490"/>
    <dbReference type="EnsemblBacteria" id="BAJ64475">
        <property type="protein sequence ID" value="BAJ64475"/>
        <property type="gene ID" value="ANT_24490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24490"/>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017487_0_0_0"/>
    <dbReference type="OMA" id="PSAFYYS"/>
    <dbReference type="OrthoDB" id="423797at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013408">
        <property type="entry name" value="Cas10/Csm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041062">
        <property type="entry name" value="Csm1_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18211">
        <property type="entry name" value="Csm1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02578">
        <property type="entry name" value="cas_TM1811_Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="11">
        <location>
            <begin position="564"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="750"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ64475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="848" mass="96051" checksum="E10AA010B23A2E2B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZJ1</accession>
    <name>E8MZJ1_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmA</name>
        <name evidence="7" type="ordered locus">ANT_25130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560894.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25130"/>
    <dbReference type="EnsemblBacteria" id="BAJ64539">
        <property type="protein sequence ID" value="BAJ64539"/>
        <property type="gene ID" value="ANT_25130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25130"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_0"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="91" mass="9771" checksum="90CA4A6A88933FDE" modified="2011-04-05" version="1">MAHKKGGGSSRNGRDSNSQRLGVKRYAGQKVLSGNILVRQRGTRIKPGLNVKVGKDDTLFAVADGIVVYKTLPNGRKMVSVIPEPEAPVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ4</accession>
    <name>E8MZQ4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_25760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560957.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25760"/>
    <dbReference type="EnsemblBacteria" id="BAJ64602">
        <property type="protein sequence ID" value="BAJ64602"/>
        <property type="gene ID" value="ANT_25760"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25760"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324333_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="700"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="776"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="890" mass="102337" checksum="A75F20E98A6B43E4" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY1</accession>
    <name>E8MZY1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_02820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558713.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02820"/>
    <dbReference type="EnsemblBacteria" id="BAJ62316">
        <property type="protein sequence ID" value="BAJ62316"/>
        <property type="gene ID" value="ANT_02820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02820"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_352205_0_0_0"/>
    <dbReference type="OrthoDB" id="961933at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035185">
        <property type="entry name" value="DUF5305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17231">
        <property type="entry name" value="DUF5305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="5">
        <location>
            <begin position="537"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="798" mass="88271" checksum="AE91DCF1DE38F0CA" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZY7</accession>
    <name>E8MZY7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_02880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558719.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02880"/>
    <dbReference type="EnsemblBacteria" id="BAJ62322">
        <property type="protein sequence ID" value="BAJ62322"/>
        <property type="gene ID" value="ANT_02880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02880"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568212_0_0_0"/>
    <dbReference type="OMA" id="YPCYRFV"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="111"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="480" mass="53283" checksum="A461F1A01F730A69" modified="2011-04-05" version="1">MKIQVMQGVLNPERMSVQDRDCSCDSPSKIPLKDGDCSCDAPAARGAFQDPVSFVSYALIHSSQFTDTPTQPQPQKISSEFIPVKSTPAFSPNASHLTLYPVLVPVAGASCWKALSAWFHLTDRCNLRCDYCYLPHRPQDMSVETGRAAVHALFRSAQSHAYTGVKIMYAGGEPLLRFPLILELHGYAQQLAEVQPIYLDEVVLSNGTLLTPEMVQALKTRGIRLMISLDGLGTGHDAQRHFADGKGSFEKVSQAVELALEHGLPPSISITVTGRNAAGLAELVEWVLERGLIFQLNFYRQSLFSQSHADLQLEEQAILAGIQAALKVIEHHLPRFSLLGILDRTTLAYPHTLPCGAGADYLVFTPQGGIAQCQMLLHHPVTTVHDPDPVSHIRADKYHLINPPVDERGECAECSWRYWCGGGCPLETRRVMHSPYHRSPNCRIYQTIFPELIRLEGLRLLHYASDPQVVRTQWLELQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N057</accession>
    <name>E8N057_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_03580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558789.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03580"/>
    <dbReference type="EnsemblBacteria" id="BAJ62392">
        <property type="protein sequence ID" value="BAJ62392"/>
        <property type="gene ID" value="ANT_03580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03580"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442582_0_0_0"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="617" mass="68311" checksum="50C68AEE778E7460" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N077</accession>
    <name>E8N077_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_03780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03780"/>
    <dbReference type="EnsemblBacteria" id="BAJ62412">
        <property type="protein sequence ID" value="BAJ62412"/>
        <property type="gene ID" value="ANT_03780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03780"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_7_0"/>
    <dbReference type="OMA" id="IVPHFYD"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="173"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="301" mass="34454" checksum="1BA1829544F5EE93" modified="2011-04-05" version="1">MWEIALVSPIFLVCAGEPVNEKKPTLLIVEDDLDIADMLNAYFRVQGYEVQTVNWGEDGVRAAQSGMPDLIILDIRLPDIDGFEVARRLRTNRRTRDIPIIFLTEKRGRDDRLKGLELQADDYITKPFDIAELRLRVRNALQRASQGTLVNPVTGMPEGKPVDEALESSLHQPDAALLVVQLRNLERFRDVYGFVAGDDLLRAVSLMMRDTVIQLGGEEDFFGHLTPSTFVIVTRDHNVHAISERIRRRLEQSFDYFYSDQHRERGLFADRPLSLEIHTLKPSTLQTQLEGLKTALQQFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>E8N079</accession>
    <name>E8N079_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6 10" type="synonym">ksgA</name>
        <name evidence="10" type="ordered locus">ANT_03800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03800"/>
    <dbReference type="EnsemblBacteria" id="BAJ62414">
        <property type="protein sequence ID" value="BAJ62414"/>
        <property type="gene ID" value="ANT_03800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03800"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_0_0"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="9">
        <location>
            <begin position="55"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="305" mass="33162" checksum="3F8D591A4F0FE7CE" modified="2011-04-05" version="1">MVSKRGDVLPDPGTSQPSGDSPLNLPPLPVAALLRSHGLAPRKSLGQNFLTDPAILRRIVESAELPPQAEVLEIGPGLGSLTRVLAQVARRVVAVELDSTLIPLLDEVVSPYGNVEVLHGDILQFDPARLMSSAGYFVVANIPYYITSAVMRHLLEASIRPQRVVLTIQREVAERICAVPGEMSLLALSVQVYGAPRVTLRIPAGAFYPPPKVDSAVVRVDLSPQPRIPAEQLEIFFRLIRAGFSQKRKTLRNALSSGLGWKGERAESLLRQAGIDPNRRAESLALEEWALLVDAYVKAEEKQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N086</accession>
    <name>E8N086_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26090"/>
    <dbReference type="EnsemblBacteria" id="BAJ64635">
        <property type="protein sequence ID" value="BAJ64635"/>
        <property type="gene ID" value="ANT_26090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26090"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_5_0"/>
    <dbReference type="OMA" id="RIAWYHT"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="31"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="191"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="41865" checksum="657F726E692DA342" modified="2011-04-05" version="1">MRCLLMGETIFLGIGGHWASGNSLSLMYRGVAEELVRRGWQVVVLIPGLSSEQVVAEGNLRILTWPSRRPTRLKDAIYLARLIKQYRPACLIANFASVNWMMLVGWLFGVKKRIAWYHTVIDAAEERNWVTELKIIRKRLIYKLATHIIAVSDFVKSRDLVTEYRVLPEKITVFHNMVGDPLSAGILPCPKEKILTYTGRLEYWKGVDILIKAMPEIVSQYPDVSLRILGDGSKRIEYQNLSRNLGVDNHILFLGSVSPNQVLQELSQSYLHLHPARADNCPLSVIEAISLGIPVIASNVGGIPEIIRDGQEGFLVSPGSHELLAEKIVQVLEDSFLRNELSRRARERFLGSFELSKGVMKIVDWLENER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N098</accession>
    <name>E8N098_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative polysaccharide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_26210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561001.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26210"/>
    <dbReference type="EnsemblBacteria" id="BAJ64647">
        <property type="protein sequence ID" value="BAJ64647"/>
        <property type="gene ID" value="ANT_26210"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26210"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_101_4_0"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="45"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="417" mass="46317" checksum="6C1BD2200ACCDBEF" modified="2011-04-05" version="1">MPSVISVEHLSKAYRLGQIGTGTFANDLKVWWAKVRGKPNPLLKIGQEDHGNRDGEIIWALKDVSFTVEQGEVLGVIGRNGAGKSTLLKILSRITAPTEGVVRVKGRIASLLEVGTGFHPELTGRENIYLNGAILGMSRKEIDRKFDEIVAFAEIEPFIDTPVKRYSSGMYVRLAFAVAAHLDAEILLVDEVLAVGDAAFQKKCLGKMGDVASQEGRTVLFVSHNMAAVQQLTLKSILLYQGRLVDKSVSSDMIRKYLSSMSLQNSSENRLTVGSITIKEIYLIQDDVRTNSIDLNSSFKFCINYHVAFPTKNILLGFDLISDTGITLFRAYDLDVFPLNEYRYGEYESVFVMPPKILQKGTYHINLIVAVHRETRLNPGKLSLSFNVDSLRQSDVDYIGIIASPGNWEVTHKLCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N099</accession>
    <name>E8N099_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_26220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561002.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26220"/>
    <dbReference type="EnsemblBacteria" id="BAJ64648">
        <property type="protein sequence ID" value="BAJ64648"/>
        <property type="gene ID" value="ANT_26220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26220"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_3_0_0"/>
    <dbReference type="OMA" id="ELNPLYH"/>
    <dbReference type="OrthoDB" id="1543624at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="39"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="290" mass="32962" checksum="2E9FF5EA52295C62" modified="2011-04-05" version="1">MNKTTSLQPQTEDWDLIIQPQRNLLDLRLGELWRYRDLILLFVRRDFVAAYKQTILGPLWYLIQPLLTTITFTVIFGRIASLPTDGLPEFLFYMSGTVIWSYFAECLNKTSNTFVQNAHLFGKVYFPRMAVPVSILISNLITFLMQFVLFLGFVGFFALRGTPIRMNLAWVALSPLLLLMMAGLGLGFGIIISSLTTKYRDLRFLVQFGVQLLMYATPVIYPVSSIPARFQPLLQANPMTPIVEAFRFAFLGAGTVNAGQLLYSFVFMVVLVFLGAVIFNRVEQTFMDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0A5</accession>
    <name>E8N0A5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561008.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26280"/>
    <dbReference type="EnsemblBacteria" id="BAJ64654">
        <property type="protein sequence ID" value="BAJ64654"/>
        <property type="gene ID" value="ANT_26280"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26280"/>
    <dbReference type="eggNOG" id="COG4742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198748_0_0_0"/>
    <dbReference type="OMA" id="ETDGMYA"/>
    <dbReference type="OrthoDB" id="2089000at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="76" mass="8111" checksum="C69D54AF644E7670" modified="2011-04-05" version="1">MACVNPDGTLTPSALTVLKAVQQAPQKAEVLAESVGLPLFRVRSSLRELREAGLLSETDGMYAITPQGEEALKKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0I4</accession>
    <name>E8N0I4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_27070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561085.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27070"/>
    <dbReference type="EnsemblBacteria" id="BAJ64733">
        <property type="protein sequence ID" value="BAJ64733"/>
        <property type="gene ID" value="ANT_27070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27070"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_1_0_0"/>
    <dbReference type="OMA" id="VITSEQW"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="289"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="487"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="752"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="851" mass="91589" checksum="20C0B83655640A7B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0K0</accession>
    <name>E8N0K0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_27230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64749">
        <property type="protein sequence ID" value="BAJ64749"/>
        <property type="gene ID" value="ANT_27230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27230"/>
    <dbReference type="HOGENOM" id="CLU_1080294_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025098">
        <property type="entry name" value="DUF4013"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13197">
        <property type="entry name" value="DUF4013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="257" mass="28639" checksum="FADEA6204322CD8A" modified="2011-04-05" version="1">MNTDTFFSPRGLASLLSFPFRNRETFTRFLFLGGFFALGWVFPLLPILISAGYLLEVLRLAAQGAQPTLPPWENWGRLLLNGLKVFGGGLVFLLPSLILAIKAFVLYFGGMVVFAALADAGREGLAFLLMFLAVTLLFVFQMLGFLFYLIGGTLLQPALAHMALRESFSALFDFKGWWRVFKASKGGFIVTFLLGVMLFYGIQLALALTFPIWIFFLFFLPVLTSFAFAYAFTLWTWLGGAAYSESLSTLEENASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0K4</accession>
    <name>E8N0K4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-ser_dehydrat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561105.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27270"/>
    <dbReference type="EnsemblBacteria" id="BAJ64753">
        <property type="protein sequence ID" value="BAJ64753"/>
        <property type="gene ID" value="ANT_27270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27270"/>
    <dbReference type="eggNOG" id="COG3616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031639_2_2_0"/>
    <dbReference type="OMA" id="WPRFYGW"/>
    <dbReference type="OrthoDB" id="1512472at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-ser_dehydrat" evidence="2">
        <location>
            <begin position="254"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="370" mass="41375" checksum="CDA71516B21096AF" modified="2011-04-05" version="1">MSIFDQIRKPTLLLDEQIVRRNIRAMAQKVAASGVHFRPHFKTHQSCQIGEWFREEGVSAITVSSVDMAKYFADCGWDDITLAFPVNLRQLDEIAHLAERIRLGVLVESVETVQALGERVRAPLAVWIKVDVGANRTGIAWDDVETASALVKTCQAYPALRLNGLLTHAGQTYQAAYPAQVEEIYRQSLSKLQSLRHVLEQQGLAQSLILSVGDTPSSSIVQDFRPADEIRPGNFVFYDVQQWMLGACTWENIGVALACPVVSLHPRRGEAVIYGGAVHLSKEYLLSKGQRFYGLVALPKDGRWSEPLPGAYVSRLSQEHGILRLFPHQLEQLRVGDLVCILPVHSCLTAQSMGRYLTLDGNWIEMMPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0M4</accession>
    <name>E8N0M4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Xre family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_03850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558815.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03850"/>
    <dbReference type="EnsemblBacteria" id="BAJ62419">
        <property type="protein sequence ID" value="BAJ62419"/>
        <property type="gene ID" value="ANT_03850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03850"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607865_0_0_0"/>
    <dbReference type="OrthoDB" id="2071222at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="450" mass="49065" checksum="A06F2EC422DB8D93" modified="2011-04-05" version="1">MTLSVGERLKQTRLEKHLTLEQVSQATRVRVHYLDALERGDLEALPSRVQGKGFLRLYADYLGLPVDEILAQWEGKPLPSPVQPSPQPEEVQESHRMPVEPAAPPPAEVEVFVPATEVPVTPPAGASSSLILLKEIGQELRRKREALGFSLADVEEFTHIRTRYLQALENGQLEQLPSPVQGRGMLQNYADFLRLDTEDLLNRFAEALQQRRIEQTIRIESPTAPRAKPITRIRRWVTPDLLIGGGLILALFLFVAWTAGRITAERTRMAQATLPSISDVLLTTPSPTPGEQSAPSTPAPQQTPLEGEGNPAPTEIPPTEGTPVSTVAPISNAPVQVYLIARQRAFLRVIVDGKIAFNGRTIPGNAYPFSAEKSIEIISGNAAALQVYYNQQDLGVLGEMGKPLRLTFTQQGVLTPTPLPTATPTATPPVTPTPTPTPLLATPTITPFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P5</accession>
    <name>E8N0P5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04060"/>
    <dbReference type="EnsemblBacteria" id="BAJ62440">
        <property type="protein sequence ID" value="BAJ62440"/>
        <property type="gene ID" value="ANT_04060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04060"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039043_0_0_0"/>
    <dbReference type="OMA" id="YNERWLE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="69"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="345" mass="39892" checksum="82AA6BC0C793FAB5" modified="2011-04-05" version="1">MLLEHYKPRSKLVTRQSVVEKPRFPVIDAHNHLAPPFGGDWEEKPINELLDRMDAAGVIHYVDLDGGWGEDILNRHLDLFKARAPERFTIFGGVDWNQWEYLGNRFPEWAAERLRIQKARGAEGLKIWKHFGLHVRDHTGARVAVDDARLDPVWQTAGELGMPVLIHIADPVAFFDPIDETNERWEELGAHPDWSFPSPPFPPFLEIVNALHRLVKRHPQTTFIGAHVGCYAENLAWVGSVLDDCPNFFVDIAARIGELGRQPYTARRFFLKYADRILFGTDVGPDLETYRIYYRFLETDDEYFNYNPGEIPLQGRWYIYGIFLPDEVLEKVYAGNARRILRIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R4</accession>
    <name>E8N0R4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_04250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62459">
        <property type="protein sequence ID" value="BAJ62459"/>
        <property type="gene ID" value="ANT_04250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04250"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_3_0_0"/>
    <dbReference type="OMA" id="IEAKTHS"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="200"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="666" mass="71985" checksum="C01345D37A461F96" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0U5</accession>
    <name>E8N0U5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">murI</name>
        <name evidence="8" type="ordered locus">ANT_04560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558886.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04560"/>
    <dbReference type="EnsemblBacteria" id="BAJ62490">
        <property type="protein sequence ID" value="BAJ62490"/>
        <property type="gene ID" value="ANT_04560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04560"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_1_0_0"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="273" mass="29605" checksum="41C301A4456B4B1B" modified="2011-04-05" version="1">MIGVFDSGVGGLSVLRAIRALMPAEPVIYLADQAHVPYGPRPLEEVRGFSQSIARFLIAQGARVIVVACNTASAAALFHLRQTFPETPFVGMEPAVKPAAETTQSGVVGVLATPATFQGALYASVVERFAQGVTLLQDTCAGLVQQIEAGNLAGEETRRILENALLPMLARGMDTVVMGCTHYPFVIPLIQQIVGEQVRVIDPAPAVARQTRRVLEAHGWLVEGNQPAPVRFLTTGDGEAFRRMIRQLLGELFPDPQVEVIQWDEQIQPELVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V2</accession>
    <name>E8N0V2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04630"/>
    <dbReference type="EnsemblBacteria" id="BAJ62497">
        <property type="protein sequence ID" value="BAJ62497"/>
        <property type="gene ID" value="ANT_04630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04630"/>
    <dbReference type="HOGENOM" id="CLU_3362879_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="35" mass="3837" checksum="16DA347CA86DC613" modified="2011-04-05" version="1">MNAGNDILGLVAVLAGIVLLLVFAWWQSRTPLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0V8</accession>
    <name>E8N0V8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_04690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558899.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04690"/>
    <dbReference type="EnsemblBacteria" id="BAJ62503">
        <property type="protein sequence ID" value="BAJ62503"/>
        <property type="gene ID" value="ANT_04690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04690"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_1_0"/>
    <dbReference type="OMA" id="SVAWLRY"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="322" mass="34573" checksum="0627EF38EBCDC4A0" modified="2011-04-05" version="1">MDLIIVLQAGVATGTILLFATLGEIFAERSGVMNLGVEGMMLLGAMSAFSIATRTGNPWLGLLVAMLAAGLISQIHAFISITLQADQVVSGLSLGFLATGLSLVLGEGLSKAGTITLIPSWTVPVLSQIPILGPIFFTDHKLLVYAGYIIIPLAWYYINHTRPGLHLRAVGEYPAAADSLGVNVYALRYLYVLVGGVFAGLAGATISLAIAPGWFSELTTAGQGWIAIGLVIFAQWDPLRAAFGAYAFGALRRLVLDIQAPMMLFGFRNPFYYNPYWGFFLEMLPYAFTIIVLVIGSREAIRRRLGAPTALGIPYIRGERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0X8</accession>
    <name>E8N0X8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_04890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558919.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04890"/>
    <dbReference type="EnsemblBacteria" id="BAJ62523">
        <property type="protein sequence ID" value="BAJ62523"/>
        <property type="gene ID" value="ANT_04890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04890"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_4_0_0"/>
    <dbReference type="OMA" id="YEYQCSD"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="73" mass="7973" checksum="A7813BE938DC4A9F" modified="2011-04-05" version="1">MPLYEYHCDECQEDFEKLVSLSECDVNPRCPACGSLRTRRQISTFATRGSSPTWSLSSPSASSGCSSKGSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0Y6</accession>
    <name>E8N0Y6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558927.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04970"/>
    <dbReference type="EnsemblBacteria" id="BAJ62531">
        <property type="protein sequence ID" value="BAJ62531"/>
        <property type="gene ID" value="ANT_04970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04970"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_4_0_0"/>
    <dbReference type="OMA" id="LWALWHL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042150">
        <property type="entry name" value="MmRce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35797">
        <property type="entry name" value="PTHR35797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="274" mass="30863" checksum="A07E694BD7895A6C" modified="2011-04-05" version="1">MNNGLTDWIKRHSLITFYLLAFLFSWLGWIPQLLTARGVWTVDHPLLSLLGGGGPTLAAVLVVWWTQGRQAVGGLFARLVQARAGWRWLGAVFAFWILVGALAWSLMMLFTPHRANLQGFSWGVLVPVFLTMLLSNVWEEIGWRGFALPRFQERFSDWHTALIMAGLWSVWHLPLLLNPKNPMSGLPWSAELLFSLALTVVYIWLYRQTGGSLFYVTVFHALSNTLAYAFLAWGVFLESYGFVVGLTALAAVVILKVYGTQQFAYPQGVDKILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N134</accession>
    <name>E8N134_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATP-dependent helicase</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_27510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561125.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27510"/>
    <dbReference type="EnsemblBacteria" id="BAJ64777">
        <property type="protein sequence ID" value="BAJ64777"/>
        <property type="gene ID" value="ANT_27510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27510"/>
    <dbReference type="eggNOG" id="COG1111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_3_0"/>
    <dbReference type="OMA" id="GAFRIVC"/>
    <dbReference type="OrthoDB" id="35275at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="268"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="940" mass="105272" checksum="CE3501182B6EBF10" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1F6</accession>
    <name>E8N1F6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_28730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561244.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28730"/>
    <dbReference type="EnsemblBacteria" id="BAJ64899">
        <property type="protein sequence ID" value="BAJ64899"/>
        <property type="gene ID" value="ANT_28730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28730"/>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="OMA" id="SARMGEM"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="241"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="470" mass="51631" checksum="985202304824D5F6" modified="2011-04-05" version="1">MSLRSRLALLFTLVLGGTLFIFGSLVYGLVSIVLTEQIDSLLAREASRLVEGLGVNTMGQFDRRWLESFEPAEGTLVIQVWDNNRRLQFARPRTWTQPLDPAARQSGRTMFSAAFSNEQHMRVLTVPLVTRRGAVGILQVGLSLALVDAVRSTLASILFFLALISIVLAALLASVAVQRTLQPLEMVTEVATTITRADDLSRRIPTPPNSDDEVGRLIQAFNQTLSRLESLFTTQRRFIADVSHELRTPLTVIKGEVSLMRKMKCGDEESLQSIESEVDRLSRLVGNLLLLAQAESGRLPLDLKPVEMDTILLEVFQQMRTLAGEKVHLEIVTLEQVSLIGDRDRLKQVLLNIVGNAVQYTPAGGVVTLGLTQTDGYARITVSDTGPGIPEEDLPYIFERFYRGEKSRTRSQGQASGFGLGLSIAYWIVQVHGGKIDVTSVVGKGTTFIIHLPLKLPEKSGDAPEGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1I3</accession>
    <name>E8N1I3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative aminopeptidase</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_05540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558984.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05540"/>
    <dbReference type="MEROPS" id="M42.010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62588">
        <property type="protein sequence ID" value="BAJ62588"/>
        <property type="gene ID" value="ANT_05540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05540"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_0"/>
    <dbReference type="OMA" id="YTLDNKA"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="35736" checksum="83E48657BF82DA53" modified="2011-04-05" version="1">MKALIQKLVETVGPSGYEEKVREVVRAEIEGLADEIKVDALGNLIARKGSRSEGGMRIAISAHMDEIGVIATHVDENGFVRFTTIGGVSPRTCIGGRVQFLNGTRGVIYMESLESATALPTLDQLYIDVGASSRETCPVKVGDIAAFDRPFMELGDRLVSKAMDDRISVAVMIQALKELSSTPHELYFIFSTQEEVGLRGATTAAYGVDPELALAVDVTRTGDTPKGVKMEVALGKGPAIKVRDSGMLSDPRVIRWMVETAEKAGIPYQLEVLEGGTTDARAMQLTRAGVPAGCLSIPTRYIHSPSEMVDYQDVLQSVRLLVALLSAPVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1L3</accession>
    <name>E8N1L3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559013.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05840"/>
    <dbReference type="EnsemblBacteria" id="BAJ62618">
        <property type="protein sequence ID" value="BAJ62618"/>
        <property type="gene ID" value="ANT_05840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05840"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_3_0_0"/>
    <dbReference type="OMA" id="WEVITAE"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="33706" checksum="E54ED39E4DBF3AC0" modified="2011-04-05" version="1">MKLIDLTIPLGIGTPAWPTYEPLQVKYFKRLAPNGANGQLLTHSNHLGTHLDGEIHFYTPGKDMASLTMDYLVHEAAIVDLSDVCGDYDVYTSKMIEERVEVKEGDILVIHTGYHHFGWDMPTADEVRYMVKHPGPDREFAEWAKKKKLRWIAVDCGSADHPMNTIIRTWMPRQAKEAEYVFKKKYGMSLEEFFSDDKYQLMHIEMFPHEIIHAECFGGEIDLLLNQRVTVGFFPWRFVDGEASIGRAVAFVDDAKYEELMKKRESMPKTRFGDAYDPTHVERLNAISRANLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1S3</accession>
    <name>E8N1S3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_06440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559073.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06440"/>
    <dbReference type="EnsemblBacteria" id="BAJ62678">
        <property type="protein sequence ID" value="BAJ62678"/>
        <property type="gene ID" value="ANT_06440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06440"/>
    <dbReference type="HOGENOM" id="CLU_1145361_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228057" evidence="2">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="242" mass="26644" checksum="BC769B2CF33F219D" modified="2011-04-05" version="1">MKKGWMVVVFLVVFLQACQPQMVSSLQLPTNTSVVIPTDTAVPSATATQTPTMTQTPTMTPTVTQSPAATPMARFNELKLLLLENKLGGWTMQWVLPGVQIPLKLLLDNREYTCTVDVKYPDRLFCQGLAQPALERPITLVFVNPENGKEIYRTEFIIPVALLKPPTPVGYAQTNCPDRGKNVSCETECRIAPDGTPCIVATCVDACGPYFSVHSCPDDMPLPSHSCTAEQWVAMKKKYQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1X7</accession>
    <name>E8N1X7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <ecNumber evidence="6">3.6.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dut</name>
        <name evidence="6" type="ordered locus">ANT_28980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561269.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28980"/>
    <dbReference type="EnsemblBacteria" id="BAJ64924">
        <property type="protein sequence ID" value="BAJ64924"/>
        <property type="gene ID" value="ANT_28980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28980"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_1_3_0"/>
    <dbReference type="OrthoDB" id="1669228at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="144" mass="15390" checksum="369F05E12B042A5D" modified="2011-04-05" version="1">MQTLRVARVRPQAKLPTRKHPEDAGLDLYAAESVTIPPHSPGIVPTGIAVDIPTGYVGLLKPKGRNDHLLGAGVIDAGYQGEILVKIVNPFPHSLVISAGEAIGQLLILPILTPGVQEVTPEELRQKPSERGSSGGIVDQFLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1Y1</accession>
    <name>E8N1Y1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_29020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29020"/>
    <dbReference type="EnsemblBacteria" id="BAJ64928">
        <property type="protein sequence ID" value="BAJ64928"/>
        <property type="gene ID" value="ANT_29020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29020"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_2_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="118" mass="13245" checksum="21E5259679C18A83" modified="2011-04-05" version="1">MVELIAMLTMPGLVRLKAVAQNEMIGFVGGDVRPQDNVGWVATLGVLPAYRGMGVGRALLRACEEKLRLRTPVVRLSVRRSNHIAIALYESAGYSIVDVWRGYYFDREDALVFEKKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N250</accession>
    <name>E8N250_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_29710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29710"/>
    <dbReference type="EnsemblBacteria" id="BAJ64997">
        <property type="protein sequence ID" value="BAJ64997"/>
        <property type="gene ID" value="ANT_29710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29710"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_2_0_0"/>
    <dbReference type="OMA" id="HPYNVSL"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR002825-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="378" mass="40802" checksum="D48943DD65CE6CF8" modified="2011-04-05" version="1">MQAPSDALPVTLDLYGEKPVMFKRLSLLFLFGMFFLGACAPVVTPQAGQPEAPAPIATRQDSAAETVGGKLVIYSGRSEALIQPVLDAFRALYPNVEIALKAGSNSEIANALIEEQSNPQADVFITTEVFTAQKLSENGVLAPYTPAQPDLLPADGRAADGTWVALTRRARVILYNTNLVPPEELPASIFDLTDPKWKGQVAAANSTNGSMQAQIAVMRHLYGEETTEAWLKGLMDNEVTFFGGHTDVRKAVAAGEFKLGLVNHYYYHLQLAEGSPVGVIYPDQGEGQKGVITNATAAGLIKGGANPTTARAFLDFLLSPEGQRIFAEQNYEYPVLPGVPLREGVRPLDEVRLAPFNLPEVVQDFDATFDLMEKVGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N290</accession>
    <name>E8N290_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall hydrolase/autolysin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561378.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30110"/>
    <dbReference type="EnsemblBacteria" id="BAJ65037">
        <property type="protein sequence ID" value="BAJ65037"/>
        <property type="gene ID" value="ANT_30110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30110"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044444_0_0_0"/>
    <dbReference type="OMA" id="CINTAYP"/>
    <dbReference type="OrthoDB" id="1878628at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="83"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="266" mass="29349" checksum="7C1E7A30AD0E202E" modified="2011-04-05" version="1">MTTSTSPSQRSHRPRRESPAVSTWRNLQTVLSVALLVATVFTFWNASNLFAAQRMSRINRLLEAARNVQESLPTPTPSPRPPIGIVAGHWGHDPGAVCPDGLSEESLNLKIATLVKQRLMQEGFQVDLFQEFDSRLNGYQALVLVSIHNDSCEYINDQATGFKVAAAQANQQTDKTERLIACLVDRYKRTVNLPYHPGSVTADMTDYHAFREISANTPAAIIETGFMNLDRDILVNQTDQVAEGVARGILCYLRNETINPGGGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N297</accession>
    <name>E8N297_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">gmk</name>
        <name evidence="11" type="ordered locus">ANT_30180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30180"/>
    <dbReference type="EnsemblBacteria" id="BAJ65044">
        <property type="protein sequence ID" value="BAJ65044"/>
        <property type="gene ID" value="ANT_30180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30180"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_2_0"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ65044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="211" mass="24309" checksum="1BC8B823C43CEF9D" modified="2011-04-05" version="1">METMDQSPLDFDLHHPKPLLIVISGPSGVGKDAVIKAMKDKGYPFHFVVTMTSRPIRPGEVDGVDYFFVSRERFEELISADEFIEYANVYGDYKGIPRSQIREAMASGKDVILRVDVQGAETVRRLCPEAVLIFLIPANKDEWLWRLKNRKTETEEALKLRVETARQELREFSKFDYVVVNAHDRLDEAVRIIAAIIEAEHHRIDHREVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B1</accession>
    <name>E8N2B1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signaling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_30320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561399.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30320"/>
    <dbReference type="EnsemblBacteria" id="BAJ65058">
        <property type="protein sequence ID" value="BAJ65058"/>
        <property type="gene ID" value="ANT_30320"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30320"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607867_0_0_0"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="210"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ65058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="450" mass="50043" checksum="570768138F93F520" modified="2011-04-05" version="1">MAGSLFSSFSRKALWSADASPAGSRFSFLEVLILTTGGGIAAGSLALWLTAHTAPIFLLVNAAFVLVLAGVWAVRLWLSSEVIRVLLFFLFWAHYFVVLMFTGGVQSPAAGMLLILIYVSGLLLGLKGSLVSILLGAGSLLVLFWMEQFGRLPPSSLPQTPLMEILFRFVIGAVFILIVYFTSRMLENYQRSLQAELTERQAAQNALALQTGQLQMVLEKSFDAFILVDETGRVVEWNPGAERLLGYCREEILGQPAVKVLERIAIPAYRTPSALSKLESVFEQALKTGKSPFFNRKTETRFLDASGEIKICELNSFALPTPLGYRIGMMLRDITSEREVREQLRLRLRHLETLNRLSTLSREEARVSPFLEKALDLLLPVLDVPAGGVAQVDKENGCYYPMATRGWVKSFEGKAFPLQGGLVEKTILQDARCSARTCAWTPGRIRKWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B9</accession>
    <name>E8N2B9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559119.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06910"/>
    <dbReference type="EnsemblBacteria" id="BAJ62725">
        <property type="protein sequence ID" value="BAJ62725"/>
        <property type="gene ID" value="ANT_06910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06910"/>
    <dbReference type="HOGENOM" id="CLU_1522139_0_0_0"/>
    <dbReference type="OrthoDB" id="2232069at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="176" mass="20122" checksum="C1149BB9B4FB0B2A" modified="2011-04-05" version="1">MDVVFQGQYTSADVVRAVLALHQSAGIWRFLRPLILAVAVILYASLVFSAATSSANSEYSWARVARHSITLLLIVYWFVSPYVKAYGLARKVKQNYQGVRVRGILSARGVELLFSSHQVEDVIPWQKFYRKRITADIISLLTLEGALWIFPRSFFKTDEDWKRAQELVRARVAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2K0</accession>
    <name>E8N2K0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_07720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559199.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07720"/>
    <dbReference type="EnsemblBacteria" id="BAJ62806">
        <property type="protein sequence ID" value="BAJ62806"/>
        <property type="gene ID" value="ANT_07720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07720"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="OMA" id="FARAIMS"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="243" mass="26649" checksum="E987C4F61539A4E0" modified="2011-04-05" version="1">MTSGATISIRQLRKTYVMGRVRVHALAGVDMDIPAGSFTVVMGPSGSGKSTLLYLLGGLERPTSGQILVDGKDLSAMDENALALYRRSTVGFVFQQFNLVPSMTALENVAFPMRFSGIRTGERLKRAKDLLTQVGLATHVKHRPTEMSGGQQQRVAIARALVHNPRLILADEPTGNLDSVTGYSIMQLLSELHQQGRTVMVVTHDPRMLRFATHTIYLLDGRVVSRDDFEKASALPEDEKNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2P2</accession>
    <name>E8N2P2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_08140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559240.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08140"/>
    <dbReference type="EnsemblBacteria" id="BAJ62848">
        <property type="protein sequence ID" value="BAJ62848"/>
        <property type="gene ID" value="ANT_08140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08140"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064706_4_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="328" mass="36433" checksum="2AA053ECA7A41963" modified="2011-04-05" version="1">MSSFSESEARSIIQRFAVPFFILGTFLIALLFWLVPRWLGLQDAVALRHWVALGSFAPALMALILQISDSQTRQDWMQDRGAENLVLSILAVGALYFICLPYASTTPVQVSLWGWTARVMLFIAGGAVLYTVLRQAVFPQSLQGWLVWLAAALAYPLLMLLAWAIWTQFGASAQINLPEGGAGGLVLSLLASYVYLFLFGGALGGEPGWRGWLLPRLLNRLPVWVAVLVVGVVEALWVVPLYFNGYYLSGDSLWQELAGRGLLTLVHAVWLGWVWVRWQGNLFPVMLLRMGMAVTPLFIAITPLSWGFLAVIALILLLNLRRFEMHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2U4</accession>
    <name>E8N2U4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_30680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561435.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30680"/>
    <dbReference type="EnsemblBacteria" id="BAJ65094">
        <property type="protein sequence ID" value="BAJ65094"/>
        <property type="gene ID" value="ANT_30680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30680"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_0"/>
    <dbReference type="OMA" id="YKQDGVG"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="411" mass="44644" checksum="A2B1527BA6758D4F" modified="2011-04-05" version="1">MTFPSRFGLSTLVNHVGEGEAPLDAHSNPIFQTSTFRFPDVATGAARFRGEEDGFIYTRFDNPNFRQAAAKIAALEGIDLLRAQPDAPMEEVVAGRMFSSGMAAITTAILARVRGGQTVIAQEALYGATYTFLHDFAPQYGIQVVWLNHPQPEDWERAFREHPDAVLAYAESPANPTMGIIDLAAAAEIAHRYGAWLMVDNTFATPYCQRPLTLGADVVVHSTTKYLAGHGVVVGGTVVSRHVEYIHKNLNATNKLLGGNPGPFDTWLTSMGLRTFELRMERHCANAMQVAAWLEQHPAVSRVYYPGLTSHPEHELAKRQMHAFGGMISFELKGGLEAGKALMENVRLLTLAVSLGTTDSLISHPASMTHSGVPPAARQAVGITDGLVRFSVGIENVEDILADLEQALKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2V0</accession>
    <name>E8N2V0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561441.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30740"/>
    <dbReference type="EnsemblBacteria" id="BAJ65100">
        <property type="protein sequence ID" value="BAJ65100"/>
        <property type="gene ID" value="ANT_30740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30740"/>
    <dbReference type="HOGENOM" id="CLU_2327765_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="98" mass="11169" checksum="117F9F7935F0800C" modified="2011-04-05" version="1">MAGRRKTPRESCPPQEQTLREEIEMLRSLIRKTAERAEEENPLPHQVRLLEAFSQACARLAQMLKVQSELSEDRGALDEIFHMADEIFREMSGKTGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W0</accession>
    <name>E8N2W0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30840"/>
    <dbReference type="EnsemblBacteria" id="BAJ65110">
        <property type="protein sequence ID" value="BAJ65110"/>
        <property type="gene ID" value="ANT_30840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30840"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1479174_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="182" mass="20305" checksum="A0806900DA3D05B0" modified="2011-04-05" version="1">MYICHYNSSPAFIKISSMFRQEYAHLAIFEGLNPQQIQALSPFLEEVRYPSGTVIFQQGNFADALCIVLEGEVQIRYKPYDGPSLVVARISPGGVCGWSAALGRDVYTSSAVANTEVVAYRLKRACLQTLCERNPELGRVWLERLASVIAERLRNTHVSILEMLTASMDLQPSSQGCQNQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2W5</accession>
    <name>E8N2W5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase B</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppiB</name>
        <name evidence="4" type="ordered locus">ANT_30890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30890"/>
    <dbReference type="EnsemblBacteria" id="BAJ65115">
        <property type="protein sequence ID" value="BAJ65115"/>
        <property type="gene ID" value="ANT_30890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30890"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649951_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228633" evidence="1">
        <location>
            <begin position="25"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="254"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ65115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="400" mass="43792" checksum="4FF40E5DF5C5E422" modified="2011-04-05" version="1">MLRKLLPLLAVMALLLGACQPQTAGGKVPISGTPMAGCEVSSVLPTPNPTLQALIPAPGKDDHILGKDTALVTIIEYSDYQCPYCAMLAPVLRQLVEKYPDDVRVVFRYFPLTSHPNSWVAAQAAEAAGKQGKFVEMHELIFAQQDQLANYTPENALDYFVTLAEQLKLNVDQFKQDYASEEVKARIQKNLDEAMNTGLPGTPFLFLNGLPYQDRMDLETLSSLVELFKLQARQYTSCPPMIIDTAKQYTATMETEKGKIVIQLYADKAPLAVNSFVFLAREGFFNGVTFHRVLPGFVAQAGDPSGSGYGGPGYVFKNENTDAKFDRKGLVAMANSGADTNGSQFFITYDAQESLNGNYTIFGEVIEGMDVVESLTPRDPASDQTLQPGTKILKVTISEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N395</accession>
    <name>E8N395_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_08750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08750"/>
    <dbReference type="EnsemblBacteria" id="BAJ62909">
        <property type="protein sequence ID" value="BAJ62909"/>
        <property type="gene ID" value="ANT_08750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08750"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_578341_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="258"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="327"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="526" mass="58961" checksum="9C23FC7A9B4AAF80" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A4</accession>
    <name>E8N3A4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-galactoside ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_08840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559310.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08840"/>
    <dbReference type="EnsemblBacteria" id="BAJ62918">
        <property type="protein sequence ID" value="BAJ62918"/>
        <property type="gene ID" value="ANT_08840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08840"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="OMA" id="VACHWAE"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="11"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ62918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="342" mass="38277" checksum="90A5A60F6C42FC02" modified="2011-04-05" version="1">MANNLQTEPILEVKNLKMHFPIRGGFFQTIKGYVKAVDGISFSVRENEVLGLVGESGCGKTTAGRTILRLYDPTDGEIWFRKKDGERVEISKFTQKQMMPLRREMRMIFQDPFSSLNPRRTVKEIIGEPLIIHNIARGRELEDRVAYLMTAVGLDPAYMDRYPHEFSGGQRQRIGIARTLSLSPRLIVADEPVSALDVSIQAQVLNLLQNLKEDLGLTLIFVAHDLSVVEHISDRIAVMYVGKIVELSETENVLYHPLHPYTEALVSAIPPADPDIKMQRIPLQGDVPSPANPPKGCVFHPRCRYAKDICSQQEPALREVEPGHFASCHFAGELSLRGIGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3A6</accession>
    <name>E8N3A6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-galactoside ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_08860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559312.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_08860"/>
    <dbReference type="EnsemblBacteria" id="BAJ62920">
        <property type="protein sequence ID" value="BAJ62920"/>
        <property type="gene ID" value="ANT_08860"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_08860"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_1_0"/>
    <dbReference type="OMA" id="LMFAGQG"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="105"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="37059" checksum="A3915E1FB7AB0476" modified="2011-04-05" version="1">MISYILRRLLLSIPLLLGISIVSFAIIQLPPGDFATTYQNFLINQANMSPVEAEKAANEYRKIYGLDRPVYEQYFNWIKGIVTEGKFGYSFAYKQDVGQLIAERLPRTLFLALSAHLISTIFGIVIGIYSATHKYSIGDYAATVFAFIGTAAPRFFLAIIAVYFLVIELKSPYVNRFVSPEYSFAPLSWAKFVDILKYSWPVIAIAGFGGIARNMRVMRGNLLDVLNMQYVTTARAKGLREDVVINKHAVPNALHPIIMYQGTVLPYMLQGELEAAIVLNMPSLAPMFYSSLVNQDIYVSGGFLLIYSVLLVLGNLIADVVLALVDPRIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3D0</accession>
    <name>E8N3D0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559336.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62944">
        <property type="protein sequence ID" value="BAJ62944"/>
        <property type="gene ID" value="ANT_09100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09100"/>
    <dbReference type="HOGENOM" id="CLU_1188994_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="279" mass="29646" checksum="4B520187D129B503" modified="2011-04-05" version="1">MRGDNRREKGQGLLEYALIILLVAAVTGLALAVSGVSLRDVYERMLNALSGKTSPASCSVSAAQLANWQGLEGNWRGGIQPAVDGFQVCQLCAGMLGGYSGSDYVLDLSGVQVENVLPANNGFGVAFRAESGENGMSGYMFEIEQQNKTKPPVVSFTKWVNGVRVNPSLGEVELPMGYDWTTSPRIQIDVRGDTFTAYLDGKPILTVKDTTYKKGGVGVATKNGTTLRFKDITAQDPACQPVQQGSSPVATATPVPSPTVGKTFFPQPVETLPPGKQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E4</accession>
    <name>E8N3E4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MatE family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559349.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62958">
        <property type="protein sequence ID" value="BAJ62958"/>
        <property type="gene ID" value="ANT_09240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09240"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_1_0"/>
    <dbReference type="OMA" id="FYWRMVS"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="481" mass="52718" checksum="CEF0E7F8752EB728" modified="2011-04-05" version="1">MKSSIQPTLQHWFPFLQDDAYLEALKSIAVPIILQQAIASVLNAVDVLMLGQLGEVSVAAVGLANQLGFLMMFVLFGTTSGAAAFISQYWGKRDIPSIRRVLGIGLSICLLASVAFLVFVQISPATALHIYTSDPEVIETGIPYLRLISLTYPMMAISFCFGMVHRSTGWVRLPTTTGIIAILIKSGLSFVLIFGWLGFPRLGVFGAAIATLIARVLETTILIFFTYWKHLPAAASVKEMYDFNFSYLKAVLAVAFPVILNESLWSLGISTYNAIYARIGTQSIAAYNIAATIEGMAFVLFIGVTDATAIMIGNRLGAGERDTAYRYGGWSLRLNLMGGVLVGGLIILASFFVPSLYNISPEAKLYARNLLVIMGACVWIRTSNMVLVVGVLRSGGDTRVGALLDVGTLWAIGVPSALLAAFVFKLEIHWVYLLVMSEELVKLLIGYWRYRSRRWMHDLTVIQKEPHPTLVPAEEILNEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3E5</accession>
    <name>E8N3E5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_09250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559350.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62959">
        <property type="protein sequence ID" value="BAJ62959"/>
        <property type="gene ID" value="ANT_09250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09250"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_113_2_0"/>
    <dbReference type="OMA" id="LWATAFQ"/>
    <dbReference type="OrthoDB" id="1293707at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="630"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ62959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="853" mass="94260" checksum="3FE461B0FB4080A8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3H9</accession>
    <name>E8N3H9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum ABC transporter substrate binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_09590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559384.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09590"/>
    <dbReference type="EnsemblBacteria" id="BAJ62993">
        <property type="protein sequence ID" value="BAJ62993"/>
        <property type="gene ID" value="ANT_09590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09590"/>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065520_3_1_0"/>
    <dbReference type="OMA" id="RIFEHEG"/>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228144" evidence="4">
        <location>
            <begin position="23"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="266" mass="29186" checksum="50563BADB3D0AEB6" modified="2011-04-05" version="1">MMNLHRTVPLILAFLLIMTACAPQQSATPSSGLVIMAATSLSECMKTFESEYQKTNPDMRLSFSFAPSQQLAQQILHGATVDLFLSADDKSIQALVEKGMITPENSGQFIANRLLVIANPHSPVVRLLDLSKPGVKIALASEESPAGKYTRQLLDKLTVQGNLGENYKEKVLQNVVSYEGTVRSVVTKVELGEADAGIVYQSDVYPSSIGKVRQILIPDSLNITAVYYYGILNTTPRQEEARKFMELLLSEKGQNIFQGCGFLPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3R3</accession>
    <name>E8N3R3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_10430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559467.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63077">
        <property type="protein sequence ID" value="BAJ63077"/>
        <property type="gene ID" value="ANT_10430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10430"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085957_2_2_0"/>
    <dbReference type="OMA" id="WVLPFEA"/>
    <dbReference type="OrthoDB" id="1683794at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="172" mass="18506" checksum="F24E87D57587EA9F" modified="2011-04-05" version="1">MSALQIVFLLIALLTLFSASMVVFARKTIHSAFWLILALFGVAATFATLEASFFAVIQVAVYIGAIAILIIFAVMLTRRSMEETGDQLLPGWGWAALVVLIAFGGIIYLLLQWQGVFQAPQVLTAGGENLEALGIALVMPDRYVIPFEVASVLLVAAMIGAIYVAGDLKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X1</accession>
    <name>E8N3X1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_11010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559525.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63135">
        <property type="protein sequence ID" value="BAJ63135"/>
        <property type="gene ID" value="ANT_11010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11010"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538247_0_0_0"/>
    <dbReference type="OMA" id="FLERIWH"/>
    <dbReference type="OrthoDB" id="202801at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="100"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="506" mass="57665" checksum="B1DB84F0F9C770F3" modified="2011-04-05" version="1">MIRRFLERIWHVVYPWVNWFQKVNAFLEKIAVPLVSRWMMGVFFAGALITLLIQVLAIQHRYQIDYGEAPLVDQAMRLSQGINIYRNNLETPPYTISNYPPLYILAITPWVSLFGPNFWAGRLISTLCAWWTAWMIYRIVFRLSGDRWAALAGGLFFIANPFVSHWSALLRIDLLALAFAVTGLELLSRVPLSTRSFWGGACCLVAAIFTRQSYALAAPLAAFIWLLFEDKAKALRLVLSVGAISLLLAGVLNVMTKGGFFFNIVTANVNEFGWERLRWNLTHLWDVLRYLLVLGAISFLQHPLRSRSWRLTAPFLVGASLSALTIGKIGSNVNYFMELCAALALAGGSVLAKIRQNPHLAWAQVLLFVFLGFQGVGMIRISLDEFGSDLAGRMKRVHELRRLEALVSAVDGPVLADEYMGMITLNRRPLYLQPFELTQLAKAGIWDETPLAESIRNKEFDLILIHYFPFFDVYKERWTPVMLAMIERNYEVFETLADTRVYIPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X4</accession>
    <name>E8N3X4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11040"/>
    <dbReference type="EnsemblBacteria" id="BAJ63138">
        <property type="protein sequence ID" value="BAJ63138"/>
        <property type="gene ID" value="ANT_11040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11040"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023775_1_0_0"/>
    <dbReference type="OMA" id="DDHNRIP"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="312"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="586" mass="68069" checksum="D88CECE6C5E3E4C6" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N428</accession>
    <name>E8N428_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ANT_11580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559580.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11580"/>
    <dbReference type="EnsemblBacteria" id="BAJ63192">
        <property type="protein sequence ID" value="BAJ63192"/>
        <property type="gene ID" value="ANT_11580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11580"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_0_0"/>
    <dbReference type="OMA" id="IIFDLRP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="164"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="358" mass="40182" checksum="0B45239403AEC13E" modified="2011-04-05" version="1">MALQVPNAGVEENPWEAFLKELDNEYEQAQRTLKEVSLMLTQSQAELAKLTQRNASITAHLQQVQAQFDTMPRSDIKMAYNAALDAQQRLLVMRGQLDKLQNDEEALRRYVTLIEKVRQILPMAGRGGKISGKGYSGSGSAMLEMVINAQEAERQRLSRQMHDGPAQALSNFIVQTEIVARLLDIDQARAKEEMASLKDAATSTFKQVRTFIFELRPMMLDDLGLFPTIKRYLESLKEQTGCDININIKGSERRYQSFLEVMIFRAIQELVGNAYRHNQESPRVQITVSLVADDTTLRVSVSDNGKGFDPEAVEKSSSLGLKLIRERVELLGGYMEIDAGIGRGARITFQVPILEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N432</accession>
    <name>E8N432_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_11620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559584.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11620"/>
    <dbReference type="EnsemblBacteria" id="BAJ63196">
        <property type="protein sequence ID" value="BAJ63196"/>
        <property type="gene ID" value="ANT_11620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11620"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_0"/>
    <dbReference type="OMA" id="KCFQALE"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="193" mass="21868" checksum="F482DE041E347368" modified="2011-04-05" version="1">MSNPRIISGKARGTRLKSVPGDITRPITDMVKEALFNILGGDIYGATFLDMFGGTGSVGIEALSRGANFCRFIDLHRVAVQTIRTNLELTRLQERAQVLQGDAFTLLSRPADRQFDYIFIAPPQYKGLWEKALATVDNHVEWLSEDGWVIVQIDPVEYSPQSLQHLEEFEQRRYGNTLLIFYERKSEESPSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N477</accession>
    <name>E8N477_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_12070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559629.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63241">
        <property type="protein sequence ID" value="BAJ63241"/>
        <property type="gene ID" value="ANT_12070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12070"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_0"/>
    <dbReference type="OMA" id="LWQMMLL"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="444" mass="47332" checksum="462C07B68C109897" modified="2011-04-05" version="1">MALQRPRGMTAFTLVWFGQVISLMGSSMSGFALTIWAWKLTGSATALSLMAFFSFGPSILFSPFAGVLVDRWNKKLVMMLSDLAAGLATIVILILYSQNVLQIWHMYVAGAFMGIFQSFQWPAYSAAISVMIPKEHYSRASGMMSLAEWGSGLLSPVLAGALIGVIGISGILLIDIVTFVFAISMLLWIVIPSVPRSQEGQEGQGSIFKEALFGFRYILNRRSLLFLQLVFFSGNLMSTLAGVLTSPMILARTGDSAPILGLVQSVGSAGGIAGSLLISVWGGPKKKVLGVLGGWFLGGLLGEMLYGLRFGLPAWIAAAFFASFFGPIINSCNQAIWQSKVPPDLQGRVFSIRRMIAQITAPLAMLMAGPLADYVFEPAMKTASSPLARLFAPLTGTGAGAGMGTIIFLSGVVILGVAIAGWMNPLVRNVETLIPDHDAVSAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N488</accession>
    <name>E8N488_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltA</name>
        <name evidence="6" type="ordered locus">ANT_12180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559640.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12180"/>
    <dbReference type="EnsemblBacteria" id="BAJ63252">
        <property type="protein sequence ID" value="BAJ63252"/>
        <property type="gene ID" value="ANT_12180"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12180"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_0"/>
    <dbReference type="OMA" id="TVGWCAQ"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="447" mass="50793" checksum="119F330617663A1D" modified="2011-04-05" version="1">MKMIEAITEQLPAWRERVNRLRTQFGSLKVCDVTVEQIYGGIRGVQIQVSDISYVDPYEGIRLRGYTIPEVLEYLPKKPGSDFPLVGGLYYLLMTDRLPNEAEADEVEQEWASRSQIPEHVYQVIRQFPRDTHPMTLFSVAIMALQPSSQFASKYAEQMFTSEGLPKGDYWKYYLEDSMNLIAKLPGIASFIYNYKYRNEEIVSYSPELDWSANFARMIGKAEDLRYQDLCRLFFVIHSDHEGGNVSAHTSYLVSSALSDVYLSCAAGMNGLAGPLHGLANQECIRWVLQVREAFGGHVPGKEELTDHLRRQLQAGKLIPGYGHAVLRVTDPRFTVQYEFAKKYISNDPNIELIGRVFEVLPPILAENGKVKNPYPNVDAINGALQYHYGVKEFDFYTVLFGMSRILGLTAHIVWGRILGKPIERPKSLTTAMLEQLAEKSLQSLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B0</accession>
    <name>E8N4B0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative [LysW]-L-2-aminoadipate 6-phosphate reductase</fullName>
            <ecNumber evidence="1">1.2.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">argC</name>
        <name evidence="1" type="synonym">lysY</name>
        <name evidence="3" type="ordered locus">ANT_12400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of [LysW]-aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + NADP(+) + phosphate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:41948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="Rhea" id="RHEA-COMP:9714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78501"/>
            <dbReference type="EC" id="1.2.1.103"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.103" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559662.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12400"/>
    <dbReference type="EnsemblBacteria" id="BAJ63274">
        <property type="protein sequence ID" value="BAJ63274"/>
        <property type="gene ID" value="ANT_12400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12400"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_0"/>
    <dbReference type="OMA" id="FSWRNNN"/>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043870">
        <property type="term" value="F:N-acetyl-gamma-aminoadipyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02083">
        <property type="entry name" value="LysY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037535">
        <property type="entry name" value="LysY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="346" mass="38051" checksum="3B308DC7F360C7BA" modified="2011-04-05" version="1">MSSLKVSIIGASGYVGGELLRLLLDHPEVEIQQVTSSSHLGEYVYQQHPNLRKRTSLKFSDPNQVTPCDVLFLAMPHGESQRKINQYAQTAPKIIDLSADFRLRDASLYTQYYGETHQAPEWLGRFVYGLPELHREEMRQASYISGVGCNATAANLALYPLVKAGVLDLSLPIIVDVKVGSSEGGATPNAGSHHPERSSVVRTFSSYGHRHTAEVIQELGLKAVHLTMTSVDLVRGALAAAHAFTLPDVTEKDLWKIYRQWSESEPFIRLVKDRRGVHRVPEPKILAGSNYVDVGFDFDPQSRRVVALAAIDNLMKGAAGSAVQAMNLMCGFEETTGLTFSGLHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4E7</accession>
    <name>E8N4E7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_12770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559699.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63311">
        <property type="protein sequence ID" value="BAJ63311"/>
        <property type="gene ID" value="ANT_12770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12770"/>
    <dbReference type="eggNOG" id="COG1586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136002_0_0_0"/>
    <dbReference type="OMA" id="MISGHFA"/>
    <dbReference type="OrthoDB" id="1670805at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="140" mass="15885" checksum="FFFFB5A98C126855" modified="2011-04-05" version="1">MSTAVNTFQLDTFEMLMPGSEGTDQPWGWHLVLNLYDCDPERIRSAEVIRRYVIELCDLIEMKRFGEPIIVDFGEDPRVSGYSLVQLIETSNITGHFANQSNAAYIDIFSCKKFDPEKAAIFTIETFGAGKAKGTFFNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4F4</accession>
    <name>E8N4F4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ftsK</name>
        <name evidence="13" type="ordered locus">ANT_12840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12840"/>
    <dbReference type="EnsemblBacteria" id="BAJ63318">
        <property type="protein sequence ID" value="BAJ63318"/>
        <property type="gene ID" value="ANT_12840"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12840"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_9_7_0"/>
    <dbReference type="OMA" id="IAWITAV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="12">
        <location>
            <begin position="427"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="444"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="774" mass="85059" checksum="5B9F358F3B65A67C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4G6</accession>
    <name>E8N4G6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5-nucleotidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559718.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63330">
        <property type="protein sequence ID" value="BAJ63330"/>
        <property type="gene ID" value="ANT_12960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12960"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059493_4_0_0"/>
    <dbReference type="OMA" id="LYPHHVN"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="218" mass="25277" checksum="03C8DC1AEEFDB612" modified="2011-04-05" version="1">MTFTTLFIDLDDTIYPPEKGVWDAIGEKINKYMETRVGIDASEVPVLRENLYRTYGTTLRGLMLTRGIDPADYLEFVHDIPLREFLHPTPELRALLERYPLRKIILTNADRNHALRVLNILELNGIFEQIIDIMDMLPYCKPLPEAFQKALEKAGNLRAEECIYLDDNVANLRTAKELGFYTIHVYPEKNCTDCHAHIPYLQYLPQVLDPLLKEVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4L0</accession>
    <name>E8N4L0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TSCPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559761.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13420"/>
    <dbReference type="EnsemblBacteria" id="BAJ63374">
        <property type="protein sequence ID" value="BAJ63374"/>
        <property type="gene ID" value="ANT_13420"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13420"/>
    <dbReference type="eggNOG" id="ENOG5032YE7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176133_0_0_0"/>
    <dbReference type="OMA" id="YKTKGTC"/>
    <dbReference type="OrthoDB" id="1928151at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023806">
        <property type="entry name" value="CHP03905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024434">
        <property type="entry name" value="TSCPD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12637">
        <property type="entry name" value="TSCPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03905">
        <property type="entry name" value="TIGR03905_4_Cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSCPD" evidence="1">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="89" mass="9846" checksum="35607EDF497E8B6B" modified="2011-04-05" version="1">MTAKTFEFEPHGVCPRKIRLELEQGRIHRVEFLGGCDGNLQGICRLVQGMGAQEVISRLMGVKCGQKPTSCPDQLAQALAIALREHEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4M0</accession>
    <name>E8N4M0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_13520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559771.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13520"/>
    <dbReference type="REBASE" id="32155">
        <property type="entry name" value="M.AthUNI1ORF13520P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ63384">
        <property type="protein sequence ID" value="BAJ63384"/>
        <property type="gene ID" value="ANT_13520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13520"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_10_4_0"/>
    <dbReference type="OMA" id="WPTKHDN"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="295" mass="33981" checksum="E05D0E62B6524BB3" modified="2011-04-05" version="1">MTWIRRVYFGDNLSILRRLPSESVHLIYIDPPFNTGKEQSRTRLRVVQSDTGNRRGFGGRTYESIPIDEKAYPDDFDDYEAFLVPRLEEAYRILTPNGSLYFHIDYREVHYCKIWLDRIFGRDCFLNEIIWAYDYGGKPKNRWPAKHDNILFYVKDPNHYTFNVDAIDREPYMAPGLVGPEKAARGKLPTDVWWHTIVGTNSKEKTGYPTQKPVGVIDRIIKASSNAGDVVMDFFAGSGTVGESCLKLNRQFILIDNHPEAIHVMRQRFAGVEGIEWINAFNTSSGDTQSLDPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4N5</accession>
    <name>E8N4N5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_13710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559783.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13710"/>
    <dbReference type="EnsemblBacteria" id="BAJ63399">
        <property type="protein sequence ID" value="BAJ63399"/>
        <property type="gene ID" value="ANT_13710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13710"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_4_2_0"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="253" mass="27883" checksum="6374AA438514F2DE" modified="2011-04-05" version="1">MKFLQFSLSGESPRTGWLYQDRIGVVEGSIFGEYRRMEAVFPLDRVRLMAPLHPGKIIAVGRNYVEHARERGAEVPEVPLIFLKPPSSVVGPGDPILLPPQSQRVDHEAELAVVIGKRGRWIAPEQAMDFVFGYTCANDVTARDLQQKDGQWTRAKGFDTFCPLGPWIETELDPFDVLIQCKVNGEVRQVGSTKEMVFSIPQLIAYISSVMTLEPGDIILTGTPAGISPLKAGDLVEIDIEGIGTLSNPVKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Q2</accession>
    <name>E8N4Q2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_13880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559800.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13880"/>
    <dbReference type="EnsemblBacteria" id="BAJ63416">
        <property type="protein sequence ID" value="BAJ63416"/>
        <property type="gene ID" value="ANT_13880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13880"/>
    <dbReference type="eggNOG" id="ENOG5033MNV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2366738_0_0_0"/>
    <dbReference type="OrthoDB" id="2053580at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="95" mass="10814" checksum="2D0CEEC78118AF6E" modified="2011-04-05" version="1">MVTQYDEKGKIFTQVISKKPVPVIVQTTQHTIRGTLHVRPSERIIDELNASIQFIAITEASVLDLQGNLVYKSNFLTLNKEHVVWIIPDEEIQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R0</accession>
    <name>E8N4R0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559806.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63424">
        <property type="protein sequence ID" value="BAJ63424"/>
        <property type="gene ID" value="ANT_13960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13960"/>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_1_0_0"/>
    <dbReference type="OMA" id="VAWVGSE"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="530" mass="58283" checksum="FD88C22525900A6A" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T7</accession>
    <name>E8N4T7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppdK</name>
        <name evidence="14" type="ordered locus">ANT_14230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14230"/>
    <dbReference type="EnsemblBacteria" id="BAJ63451">
        <property type="protein sequence ID" value="BAJ63451"/>
        <property type="gene ID" value="ANT_14230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14230"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_0"/>
    <dbReference type="OMA" id="RRFVQMY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="30"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="439"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="535"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="856"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="769"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="792"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="BAJ63451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="899" mass="100424" checksum="A92C285D87ADB4C1" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B2</accession>
    <name>E8N5B2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_16000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560006.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16000"/>
    <dbReference type="EnsemblBacteria" id="BAJ63626">
        <property type="protein sequence ID" value="BAJ63626"/>
        <property type="gene ID" value="ANT_16000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16000"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_0"/>
    <dbReference type="OMA" id="LIVCNEK"/>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="377" mass="42779" checksum="8E600A96A66D4949" modified="2011-04-05" version="1">MDYSHYFAVIMAGGGGTRLWPLSRQHHPKHMIRLGGDQSFFQQTVERLKGLISTKHILVVTVKEQASELQLQCPEIPAENYLLEPFPKGTASVVGLASVAIYARDPEATMIVLPSDHVIKNVEAFQHLAKSAYRLAQEKRLVTLGIKPTRASTGYGYIQRGEFLGYYENLPAFRVVKFTEKPDRETAQHFIESGNYDWNSGIFIWRVDQIRQEIQTSMPELYDAMERLSLVWNTGHWIKAVQQEWANLKTETIDYGIMEKTSRAVVLPAEGLGWNDVGAWDSFFEVFEPDESGNVLHQSKHLGLSTNNTLVVSEKPERVIVTIGVNDLIIVDTSDALLVCSKEQVQRVKEIVALFREGNSKELKELLRFGDDPQRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5B4</accession>
    <name>E8N5B4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">rimM</name>
        <name evidence="6" type="ordered locus">ANT_16020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16020"/>
    <dbReference type="EnsemblBacteria" id="BAJ63628">
        <property type="protein sequence ID" value="BAJ63628"/>
        <property type="gene ID" value="ANT_16020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16020"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_3_1_0"/>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="115"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="187" mass="21188" checksum="074854FD71850DF7" modified="2011-04-05" version="1">MNRKPSSSPRSKKQTAGSPVEGEPVFVAVGFLRRPHGIHGEMLMDVLTDFPERMKPHRQLFLGDSHEPVRIEKVRWADQSMLIKFEGMDDAEALGRFRNTVVYVLADQLPPLPEGQYYHHQLLGLRVVSDEGQFLGVLEQILETGANDVYLVHTPEDKEILLPAIEEVILSVNLEDGEMVVHLQEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5D2</accession>
    <name>E8N5D2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tatA</name>
        <name evidence="8" type="ordered locus">ANT_16200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms a complex with TatC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560026.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16200"/>
    <dbReference type="EnsemblBacteria" id="BAJ63646">
        <property type="protein sequence ID" value="BAJ63646"/>
        <property type="gene ID" value="ANT_16200"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16200"/>
    <dbReference type="HOGENOM" id="CLU_086034_6_2_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="61" mass="6654" checksum="6362D6C2AE044F13" modified="2011-04-05" version="1">MPIRLGVPELVLILVIVILLFGVGRIGKIAGELGSGIRAFRDGLKSPEEKAEEKKPEEKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5G0</accession>
    <name>E8N5G0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein 70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_16480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560053.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63674">
        <property type="protein sequence ID" value="BAJ63674"/>
        <property type="gene ID" value="ANT_16480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16480"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038461_0_0_0"/>
    <dbReference type="OMA" id="NFKRGIG"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="529" mass="59778" checksum="E5195BE966B2E24D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I6</accession>
    <name>E8N5I6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_16740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560079.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16740"/>
    <dbReference type="EnsemblBacteria" id="BAJ63700">
        <property type="protein sequence ID" value="BAJ63700"/>
        <property type="gene ID" value="ANT_16740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16740"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796066_0_0_0"/>
    <dbReference type="OMA" id="HIIVCGC"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="3">
        <location>
            <begin position="267"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="348" mass="38859" checksum="44D65A8A1094F4F1" modified="2011-04-05" version="1">MRGNKKPSFFRSLRASWRDTVLLFREFRLPLFVFLGILFAGGVSYHTLSQSTDSPTQSLSEALYTVLTLIFLQPIQPYPKSWYLQIFYFLMPLLGLSVLAQGLTEFGILFFNRRARNKEWQMAVASTYHKHIILVGLGHLGTRVVTLLRDLDEDTVVIEIAPRPDLKSLLHRLDIPLIEDDATREEVLLAAGVSRAKAIMLLTQNDSLNLEMALKARKINPGIQVIVRIFDDEFADSLQKQFGFQAFSATGLAAPIFAATAAGIDMTPPISIEGKPHTLAKILVSPSSHLIDKTINQIEEQFRVSVVFLQQNGQMVFHPEGGLKVVEGSTLAIFGPPGQIHQIVNENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5J4</accession>
    <name>E8N5J4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16820"/>
    <dbReference type="EnsemblBacteria" id="BAJ63708">
        <property type="protein sequence ID" value="BAJ63708"/>
        <property type="gene ID" value="ANT_16820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16820"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688203_0_0_0"/>
    <dbReference type="OMA" id="ISIFELT"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="400" mass="45875" checksum="0BD0D8EB1D7F6B08" modified="2011-04-05" version="1">MNEERVLNLDNIQDFTRRKHFPGTLNNEFDRILRRFDDIEKISSSLFSVILFLLATFVTYPNYVQTLILFAFFIADWLLLLLLPVKKISFGPAKPPALILAILRIPFALLPFPLWLASQFLGTLLVIYGFWIEPQRLRVTYQKLETEKFPKNFSLRVLHLGDLHLERITQREKILNEWIQRLQPDIILFSGDFLNLSYNEDPVAIQQVREILKEWNAPLGTFAVTGSEAVDLENVVPLILDGIPIRWLKNETVIVEKDSTPFAISGITCSHRPFQDEPILQKLSENLPNVFSILLYHSPDLAPNAARYSFDLMLAGHTHGGQVCFPLIGPLFTASLYGRRFQSGRYQIRDLVLYITRGIGLEGKAAPRVRFLCPPEIILWEIQGITNQSTNETPSMEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5K5</accession>
    <name>E8N5K5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M28 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16930"/>
    <dbReference type="EnsemblBacteria" id="BAJ63719">
        <property type="protein sequence ID" value="BAJ63719"/>
        <property type="gene ID" value="ANT_16930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16930"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045003_2_0_0"/>
    <dbReference type="OMA" id="AHWDSRP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="93"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="303" mass="33767" checksum="E413988113FB92D7" modified="2011-04-05" version="1">MRQRTFRLLLTSLLALVCMLLLLWLLRKPVLAPTTFNAERAYQDVLTQVSFGARHPGSEGHQQMLVWLSDQLNEAGWSVEIQQAGTPEAPILNLIAHRNQGAPLIILGAHYDTREFADRDPDPEKQTSPVPGANDGASGVAVLLELARVIPSDLPVEVVLVFFDAEDQGQIKQQNWIQGSTVFADSLIDMPQAVVIVDMVGDSTLRLPLERNSSPKLQQTLWKIAQELGYETIFVNEPGPSILDDHIPFIQRGIPAVDIIDFGYAFWHTTQDTPDKVSPQSLKAVGDTLLEWLVKYHGRIHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5P9</accession>
    <name>E8N5P9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_17370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17370"/>
    <dbReference type="EnsemblBacteria" id="BAJ63763">
        <property type="protein sequence ID" value="BAJ63763"/>
        <property type="gene ID" value="ANT_17370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17370"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1821396_0_0_0"/>
    <dbReference type="OMA" id="CYHAFRL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="141" mass="15074" checksum="4C146B995DCE44FE" modified="2011-04-05" version="1">MFTKPQQINSHFHLPNLKVLGLGGGGSNAVNRMIELDLKGVEFIAANTDLQALKQSLAPKKIVLGPRTTRGLGAGGNPIQGELAAEESFNVLCDVLRGADMVFLTAGMGGGHRNRLHSCCRPGCSLSWSSNRGDCYHAFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5X7</accession>
    <name>E8N5X7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 2-oxoglutarate ferredoxin oxidoreductase alpha subunit</fullName>
            <ecNumber evidence="4">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_18150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.3" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560218.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18150"/>
    <dbReference type="EnsemblBacteria" id="BAJ63841">
        <property type="protein sequence ID" value="BAJ63841"/>
        <property type="gene ID" value="ANT_18150"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18150"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_0"/>
    <dbReference type="OMA" id="GMPTRTQ"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="32"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="231"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="615" mass="68876" checksum="40B333EBECC3461C" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N659</accession>
    <name>E8N659_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rplA</name>
        <name evidence="10" type="ordered locus">ANT_18970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560300.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18970"/>
    <dbReference type="EnsemblBacteria" id="BAJ63923">
        <property type="protein sequence ID" value="BAJ63923"/>
        <property type="gene ID" value="ANT_18970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18970"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_0"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ63923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="238" mass="26000" checksum="CC240D48E0C08C23" modified="2011-04-05" version="1">MAKHGKKYLQALAKIDPNRVYEPKQALELIKEISYANFDATVEVHMRTGLDPRQADQQVRDVVVLPHGLGKTVRVLVFAQGDGATLAQQAGADYVADTDEWIQKIQGGWTDFDVAIATPDMMGKVGRLGRILGPRGLMPNPKAGTVVPAEDLPRVIKESKAGRVEFRLDKSANLHVPIGKVSFDVEKLYENLSALMEAIRKARPAAAKGVYIRRVTITPTMGPGVRIDPNVALSLTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N676</accession>
    <name>E8N676_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase</fullName>
            <ecNumber evidence="3">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="3"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560316.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19140"/>
    <dbReference type="EnsemblBacteria" id="BAJ63940">
        <property type="protein sequence ID" value="BAJ63940"/>
        <property type="gene ID" value="ANT_19140"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19140"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007436_0_0_0"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="335"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="615"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="860" mass="99315" checksum="5188B9AC72B44857" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N681</accession>
    <name>E8N681_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19190"/>
    <dbReference type="EnsemblBacteria" id="BAJ63945">
        <property type="protein sequence ID" value="BAJ63945"/>
        <property type="gene ID" value="ANT_19190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19190"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112023_1_0_0"/>
    <dbReference type="OMA" id="QTCWDAD"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="142" mass="16154" checksum="BB65C99C5511FB39" modified="2011-04-05" version="1">MRLAQSTGARLDVVALFALSHDVCRTNEGIDRQHGLESAKWIQKLNGKYFHLDEEGMDLLVRAIRYHSDGLIHEDVTVQTCWDADRLDLARVSIFPTPERLCTTAARNADILSWATERAFRKVPAFETLKQWGLDLNTCVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B3</accession>
    <name>E8N6B3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_19510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19510"/>
    <dbReference type="EnsemblBacteria" id="BAJ63977">
        <property type="protein sequence ID" value="BAJ63977"/>
        <property type="gene ID" value="ANT_19510"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19510"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_405273_0_0_0"/>
    <dbReference type="OMA" id="GINHESL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025101">
        <property type="entry name" value="DUF4012"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13196">
        <property type="entry name" value="DUF4012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="678" mass="76415" checksum="6B2B33B524A91CCB" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6B4</accession>
    <name>E8N6B4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19520"/>
    <dbReference type="EnsemblBacteria" id="BAJ63978">
        <property type="protein sequence ID" value="BAJ63978"/>
        <property type="gene ID" value="ANT_19520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19520"/>
    <dbReference type="HOGENOM" id="CLU_2986462_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="57" mass="5914" checksum="04CA829F7D74C2B1" modified="2011-04-05" version="1">MFDGMGVWISFALAPSLVGGIGDGEDADGCTWVALLSCIVGVLEDKVELIRVGVFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXP3</accession>
    <name>E8MXP3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_20980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560494.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_20980"/>
    <dbReference type="EnsemblBacteria" id="BAJ64124">
        <property type="protein sequence ID" value="BAJ64124"/>
        <property type="gene ID" value="ANT_20980"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_20980"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_4_0_0"/>
    <dbReference type="OMA" id="RIDLMAY"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="30268" checksum="BB1894BAEAD3D468" modified="2011-04-05" version="1">MLDWLIQPLQYPFMVRGIGAAVLVGIVCAVVGSFIVLRGMAFFGDALAHAILPGLAVGYLVGGGDRQVLFWWALGTAIVSGLSIGAVSRSTRIREDTAIGIIFAGMFALGIALISTVRSYTVDLAHFLFGDILGVTSTDINLILIFSSVVIGLIFLFYKEFVLLSFDPVLATTLRLPVRFLDNLLLVLIAITIVVSLQTVGVALMVAMLITPAATAYLLSKRLPVMMTLAAIIASFSGIAGLYLSYYLNIASGAAIVLTTTFIFLLVWSAQVLWQQKSKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXU8</accession>
    <name>E8MXU8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560549.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21530"/>
    <dbReference type="EnsemblBacteria" id="BAJ64179">
        <property type="protein sequence ID" value="BAJ64179"/>
        <property type="gene ID" value="ANT_21530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21530"/>
    <dbReference type="HOGENOM" id="CLU_1500553_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="179" mass="19691" checksum="A1DCFC8D7E0A31DE" modified="2011-04-05" version="1">MEWYTPFVWIANGLLALVWLLVEHLWQVGLAGALGYAVLRAPVSQQRWTLGVAVLALLAGLLAPFPVALFLLVMTLAGLLAVRLERFNPQNTHWMLVRGLGLYALTGLGFAAYREWLLPALSDPALLQGQAYLNAIASIALYLLPLGYLALLAQGLLVHPPVQQDADEIIYHFRSRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV2</accession>
    <name>E8MXV2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">ANT_21570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560553.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21570"/>
    <dbReference type="EnsemblBacteria" id="BAJ64183">
        <property type="protein sequence ID" value="BAJ64183"/>
        <property type="gene ID" value="ANT_21570"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21570"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151920_0_0_0"/>
    <dbReference type="OMA" id="ACELADQ"/>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="140" mass="15382" checksum="AF7DA8617AF0CEA3" modified="2011-04-05" version="1">MSPVTVDASVWINAFRPGEEGSRESLAFLEKIRQSREPMISPTLLLPELAAVLARGGEKSENVLRFVKSVKSLPHQVWVSLDETTAQVAVELAEQCKLRGADAVYGAVALRFGSVLVTRDREQLDRLKGVISVNLPKELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXV4</accession>
    <name>E8MXV4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21590"/>
    <dbReference type="EnsemblBacteria" id="BAJ64185">
        <property type="protein sequence ID" value="BAJ64185"/>
        <property type="gene ID" value="ANT_21590"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21590"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1802065_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="143" mass="16062" checksum="E191EBC4C22C8FBD" modified="2011-04-05" version="1">MFLDTSVIFAAVLSPEGGERMVFRLGESRLVHLWIGGQVLKECEAVILRKAADSLPNMALLLDTAKVQIGAEASPTRLEHARQLVAYPPDAIVLAEAIESQPDWFLTHDHQHFLKGPTEELSFRVGTPGDFLRWFRENIVRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXW2</accession>
    <name>E8MXW2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21670"/>
    <dbReference type="EnsemblBacteria" id="BAJ64193">
        <property type="protein sequence ID" value="BAJ64193"/>
        <property type="gene ID" value="ANT_21670"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21670"/>
    <dbReference type="HOGENOM" id="CLU_1648623_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="160" mass="18026" checksum="20EB3EC3B3362127" modified="2011-04-05" version="1">MRMQDWRWYGVYGLVVGLTGLGIWRLIEPWLWEREYVVRLLATFGVAVLLGGVLHEGLHLREALRQGASWDGVKAGWLRFRVEKPLEVGAYRRVMVAPLLLPVVFGGLVAIFDERQGLLTALVWLLGSADDLADWAALWGKKGWVTRRVGEGLRLHGGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXY2</accession>
    <name>E8MXY2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21870"/>
    <dbReference type="EnsemblBacteria" id="BAJ64213">
        <property type="protein sequence ID" value="BAJ64213"/>
        <property type="gene ID" value="ANT_21870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21870"/>
    <dbReference type="HOGENOM" id="CLU_2505544_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="85" mass="10159" checksum="774BEF6460093D78" modified="2011-04-05" version="1">MYPLTRQAGERNRRTTSHPELTACQKGGAWNMDELTPDELDELLAFEAERREQEERKFELLYRLERLPAEDPLWEDLARRLGMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ1</accession>
    <name>E8MXZ1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative S9 family peptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_21960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560591.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21960"/>
    <dbReference type="EnsemblBacteria" id="BAJ64222">
        <property type="protein sequence ID" value="BAJ64222"/>
        <property type="gene ID" value="ANT_21960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21960"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012236_1_0_0"/>
    <dbReference type="OMA" id="EVWCVLE"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="416"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="624" mass="69609" checksum="84D4563887B56882" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8MXZ2</accession>
    <name>E8MXZ2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_21970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560592.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_21970"/>
    <dbReference type="EnsemblBacteria" id="BAJ64223">
        <property type="protein sequence ID" value="BAJ64223"/>
        <property type="gene ID" value="ANT_21970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_21970"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_6_2_0"/>
    <dbReference type="OMA" id="EDCGYTN"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S15" evidence="1">
        <location>
            <begin position="91"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="293" mass="32333" checksum="57F0B70DABA0831A" modified="2011-04-05" version="1">MKLSRNIFKLLLIFWIALGAGWSGGILYVSQQYVDRLLHPACVYLMENSPFGFEDCSVSLPSGERLKGWWHPPRNGVAVLLLGGHGSSRDSLMWEARLLAQHGFGVLSVDSRVCAGLPATLGVRESEDAQVALEWIQSQPEVEQVAILGFSAGGVAGIRLAARNPQVVAVITEGNYPSLKEEVLDTPPAVPFSLRWQLQHGVAFLLGIRLGMPIEAIRPIEDLEKIAPRPILLIFGEKEALDTRALDQYQAAKEPKTLWIVPGADHGQYKDKAPQEYEVLLIQFLNQLSQIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY32</accession>
    <name>E8MY32_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_22370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22370"/>
    <dbReference type="EnsemblBacteria" id="BAJ64263">
        <property type="protein sequence ID" value="BAJ64263"/>
        <property type="gene ID" value="ANT_22370"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22370"/>
    <dbReference type="eggNOG" id="COG4113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_1_3_0"/>
    <dbReference type="OMA" id="AYDAFYV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="142" mass="15917" checksum="A109F5965079F507" modified="2011-04-05" version="1">MRSAVIDANLAIYAIIPSSKHEQALNLLETLAERNIPVYVPQLWVSEVTTGIRKSMVMGSVSTETALLALQAVLALPIEKVSEDPDLCIQAYHWAERLGQLAVYDAMYLALAERMQADFYTADQRLFNRCQQLGAEFVKWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY92</accession>
    <name>E8MY92_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_00030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558435.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00030"/>
    <dbReference type="REBASE" id="32143">
        <property type="entry name" value="M.AthUNI1ORF30P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62037">
        <property type="protein sequence ID" value="BAJ62037"/>
        <property type="gene ID" value="ANT_00030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00030"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_3_0"/>
    <dbReference type="OMA" id="WERLIQF"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="291" mass="34333" checksum="9BB9A85AC32D2009" modified="2011-04-05" version="1">MRVETRLMLGDCREKLKEIPDNFIDLIFTSPPYADSRSNTYGGIKPDEYVEWFLPISKELLRVLKPTGTFILNIKEKVVNGERHTYVIELILEMRKQGWLWTEEFIWHKKNSYPGKWPNRFRDAWERLLQFNKQRHFHMYQEEVMIPMGSWADKRLKNLSHTDLVRDNSRVGSGFGKRVANWIGRNKVYPTNVLHLATETKNRNHSAVFPEDLPEWFIKLFTREGDWVLDPFMGSGTTNRVAQRMGRNSIGIEILPEYFALSQQSIQPVLEVPEQLMLLEEKEPYDAHPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN1</accession>
    <name>E8MYN1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560733.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23410"/>
    <dbReference type="EnsemblBacteria" id="BAJ64367">
        <property type="protein sequence ID" value="BAJ64367"/>
        <property type="gene ID" value="ANT_23410"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23410"/>
    <dbReference type="HOGENOM" id="CLU_2821695_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="66" mass="7550" checksum="57BBAA6B2031EDC3" modified="2011-04-05" version="1">MNPKDNLKRVYAMELQALPVQLVPPDPIGMEPPRRSKKALTEEPQPPAPENDPKVVNRLIDRIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYN4</accession>
    <name>E8MYN4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsQ</name>
        <name evidence="5" type="ordered locus">ANT_23440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_23440"/>
    <dbReference type="EnsemblBacteria" id="BAJ64370">
        <property type="protein sequence ID" value="BAJ64370"/>
        <property type="gene ID" value="ANT_23440"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23440"/>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808087_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA_1" evidence="4">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="FtsQ" evidence="3">
        <location>
            <begin position="188"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="343" mass="38307" checksum="E670F4637029E1F7" modified="2011-04-05" version="1">MNQSRSSNRSRIEELRQRRAQRTTQRADTASRRVTTPPPTRPVVVRNTTFGTPIHRQVATQRPRRTYYVATGMPGVEMRLPSIPVIRPGWRALSAMIVLVALIGIFSLWASPFFQVDSVALEGMERLTTSDLEPVLNLRNLAIVEVDAGAVKEELMRFFPDLENVQVVVGLPNTVKVIVRERRPILAWQKEDQVMWIDASGIIFPARGTVEGLLTVFSNDTPPLAVAPVENNSEGETQGNASAGNSKPSLKTAPERMEPKTLQTIQKLATLLPENSVIAYDEMNGIGWKTPDGLQVYIGKDLANFEVKYNMAEQIIAQLYQRGIYPALLNVADPNAPFYRMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYS5</accession>
    <name>E8MYS5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_23850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560777.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ64411">
        <property type="protein sequence ID" value="BAJ64411"/>
        <property type="gene ID" value="ANT_23850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_23850"/>
    <dbReference type="eggNOG" id="COG4712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080293_0_0_0"/>
    <dbReference type="OrthoDB" id="1038465at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="257" mass="27811" checksum="D4C79DFA015F9294" modified="2011-04-05" version="1">MSTLSSIFTLTGLTLEQAVQQLDQELPAGAYKAVPGAVDLTDIDPNWMRKVLNHIFGLCGYGWGYEFSPGDLEHRYESRTNARGNEYGVYVAVLTHLRFWYKLVDGNTQYNCSVHATGASENANIAYAMKGAITNALGNAVSNIGFQESVYLGLRSHKDFQNVPNGNGKVNAPQPAPAAEPAAEGELADPGQTVIHFGKMKDKTLAEVWASGAAGKGWIRWAANTDGKGFDPQGKPENIRLQRMARAFLSLQAAYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYU5</accession>
    <name>E8MYU5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560787.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64431">
        <property type="protein sequence ID" value="BAJ64431"/>
        <property type="gene ID" value="ANT_24050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24050"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_654960_0_0_0"/>
    <dbReference type="OMA" id="VEHPRET"/>
    <dbReference type="OrthoDB" id="1300048at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="340" mass="36884" checksum="A89ED3307C07712E" modified="2011-04-05" version="1">MVVPRLEAYEFVIRAAGYQSTVRQGTGLEPVSVLLVFLQPQAGQGQTYRVFLPLVLQPNSVVIPPYDPQAALNRLNAWRRLAGVPVVQGNPQLHAGCRAHARYTAQNALLGHVEDPQLPNYTAEGDFCGQAGVVSLGAEVYPSDEQMVDALLVSPFHALYALDPRLVEVGFGSYRHADIWGGVFSAAALDVFHGLDSGQSVTPWVFPGWGKTVEYLTYDGRGIPDPLTSCPGYTAPSGTVLIAAFGEGEVEVEWSTLNRGSEVLEHCVLTAATYTHPNPEVQREGRAALWAQGAVLLVPRQPLQAGNWYAFTVRLKDGREAHGLFQTAPTPKQAVTMQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYU9</accession>
    <name>E8MYU9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560791.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24090"/>
    <dbReference type="EnsemblBacteria" id="BAJ64435">
        <property type="protein sequence ID" value="BAJ64435"/>
        <property type="gene ID" value="ANT_24090"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24090"/>
    <dbReference type="HOGENOM" id="CLU_905024_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="32698" checksum="020827C62050FB37" modified="2011-04-05" version="1">MTHTLAQLLMAVSLAALAYYALEAVAKNRGRAAKTLADYYQPLTPQEEKPIRTGSLEHKVRLAGVQYRLNVVGKEKAYYYGGMVVVALAALLALMFLGVPLPLYLLAPVLGWVVVSGQVNGAWSKMRMALEKELPTFLLRMSATIQATPNVPEAVADVTASLDPAGPLQAWMKRLLTAMQTGGRKGLEEMREEAAAISPSLMLAVMELERLWETGGSGYVEAFRLASDNLASILEGRAMAAAKADGAWGTVRVILLALGGSLVVAMSSGAGGGLFNTPAVQLGLLLALAWAALGWNVIGDMIREVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MYX8</accession>
    <name>E8MYX8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_24380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24380"/>
    <dbReference type="EnsemblBacteria" id="BAJ64464">
        <property type="protein sequence ID" value="BAJ64464"/>
        <property type="gene ID" value="ANT_24380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24380"/>
    <dbReference type="HOGENOM" id="CLU_2033249_0_0_0"/>
    <dbReference type="OrthoDB" id="2139842at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="121" mass="13824" checksum="4A5BFD8D588D1364" modified="2011-04-05" version="1">MFAEQNAERNRTKQNDSERNKTTSRRDAMAEIDLKQEVRFNPYRVRRFGLSSTQEAKALLYLERQGDTPRKFLARLFDLRLVERLVALGLVVHRGDTYGITESGRAVLQGCLGDDHGRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZ91</accession>
    <name>E8MZ91_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_02000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558632.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02000"/>
    <dbReference type="EnsemblBacteria" id="BAJ62234">
        <property type="protein sequence ID" value="BAJ62234"/>
        <property type="gene ID" value="ANT_02000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02000"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_0_1_0"/>
    <dbReference type="OMA" id="YLRMHGR"/>
    <dbReference type="OrthoDB" id="1068600at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="247" mass="28744" checksum="487D7532CDE0121B" modified="2011-04-05" version="1">MNGTSTPYRIGTSGWTYDHWRGLFYPENLPKTRWFAHYAQTFDTVEINATFYRTFGESTYRKWREQAPEGFTYVLKAPKPITHYKFLQDVEADIRAFWESAALLGNQLGMILLQLAPSTPYDPERLRAALRTFPDPARVAVEFRSERWLTDETRALLEESGACFCDADAPRAPLRGWLTGRTAYLRLHGRSRWYAHCYTDAELDEIAALARRHVEQVAERVYIFFNNDFEGYAPENARSLIQRLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZB5</accession>
    <name>E8MZB5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">rbfA</name>
        <name evidence="3" type="ordered locus">ANT_02240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558656.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_02240"/>
    <dbReference type="EnsemblBacteria" id="BAJ62258">
        <property type="protein sequence ID" value="BAJ62258"/>
        <property type="gene ID" value="ANT_02240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_02240"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_5_0_0"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ62258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="135" mass="15206" checksum="C4C67B5AEEB7722B" modified="2011-04-05" version="1">MPSKIRLKRIEDRIREDLAELLVREVADPRLAGISVTDVKVDRELAYADIFVSAVEGQARKEEVLEGLRHAAGFLRSALAANIELRTFPRLRFHWDVTPERADHIERLLASLREQEGASPASPTPTPPEDEDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZD2</accession>
    <name>E8MZD2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_24540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_24540"/>
    <dbReference type="EnsemblBacteria" id="BAJ64480">
        <property type="protein sequence ID" value="BAJ64480"/>
        <property type="gene ID" value="ANT_24540"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_24540"/>
    <dbReference type="eggNOG" id="COG1517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025124_1_0_0"/>
    <dbReference type="OMA" id="FDITHAF"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011742">
        <property type="entry name" value="CRISPR-assoc_prot_TM1812"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019016">
        <property type="entry name" value="Csx1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09455">
        <property type="entry name" value="Cas_DxTHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02221">
        <property type="entry name" value="cas_TM1812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="410" mass="46771" checksum="CF1A6A7F38520D14" modified="2011-04-05" version="1">MMKLLTFLGLGNYTPTTYTWDGQEMETSFAPLASCRFLKADQIVVFLTQKARENVFNNFIKHAQESVQANVIPVDIPAGAKEEELWQIFSAILEQTSPDEELAFDVTHGFRSSPMISLLAAAFMRSAFNVKLKAILYGAYDAKDEANRTPIFDLSPMITLLEWAVAADRFNRTGDSRYFASLIREQQKSLALRGMLEEAGTLGKLQKNLTELSLYLHMIRPEQAMQAAEELKDHIECSTSALEKAMGTLPFRALLNTVKEAYHPVAHHAKPKDLAQLKEMLATERIMIGWYIERELWMQAAALIREWLVSWVMAQMGEVNISNRTNRERFESVISIEAHAFLNAKHQQPPFSSTFLSNLPEQEQFFGRWLSFTEPRNDLMHAGQRDDSKEPNTLISQIKETYNWLVTLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI2</accession>
    <name>E8MZI2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaJ</name>
        <name evidence="10" type="ordered locus">ANT_25040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560885.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25040"/>
    <dbReference type="EnsemblBacteria" id="BAJ64530">
        <property type="protein sequence ID" value="BAJ64530"/>
        <property type="gene ID" value="ANT_25040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25040"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_0"/>
    <dbReference type="OMA" id="WDAGFEF"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="144"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="161"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="371" mass="40867" checksum="58E81A394C070FC9" modified="2011-04-05" version="1">MTQRDYYEVLGVPRTATPEEIKSAFRNLARQYHPDVNKSPDAEEKFKEINEAYAVLSDAEKRAAYDRYGHAGLNGMGGMPDFSTIDLSDIFEELFGFGIGMGSRRASRNAPRRGADLNTTLTLTFEEAVFGCEKEVEFTRDEICSSCRGSGAEPGTRPQRCVTCGGRGEVRQVRQTILGSMVQVITCPTCNGSGEVIDSPCRTCRGRGLERKTVRKVVAIPAGIDSGQQIRLAGEGQPGVNGGPNGNLYIEIQVKPHAYFRRKQDDILLNLNINIAQATLGAEVEVPTIDGKTTLSIPPGTQPGKVFTLKGKGVPHLRSNGRGDQLVIINVEVPTRLTQEQRRLFEQLAQTLGSEVKPQEKNFFERLRDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZI9</accession>
    <name>E8MZI9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">ANT_25110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560892.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25110"/>
    <dbReference type="EnsemblBacteria" id="BAJ64537">
        <property type="protein sequence ID" value="BAJ64537"/>
        <property type="gene ID" value="ANT_25110"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25110"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_0"/>
    <dbReference type="OMA" id="GMLKSHY"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="360" mass="38381" checksum="AF5F463A5D257ADE" modified="2011-04-05" version="1">MIGRVTRRIFVDSHSPALDALLEATECLRSGGLVAFPTETVYGLGGNALDGRAVQRIFEAKGRPANDPLIVHLPSADALPMVVKTIPTIVSTLAEHFWPGPLTLILPRGDNVPLSVTAGLDTVAVRVPSHPVAQALLQMSGLAIAAPSANRFGGVSPTSAEHVLRDLEGRIEMVLDGGSTPIGVESTVLDITAPIPRILRPGGISREALEAVLGRVELLERKASQEEAQASPGLLDKHYAPHHARLILLEIPQTQELWEEFTHQVAQAKKEGLRVGALVADEDLTYLDAHFPALARLALGSLSDLAAVARNLYAGMRAMDEAGIDILLVRDFGTGGLGLAIRDRLYRAASQIIRRAQNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZL6</accession>
    <name>E8MZL6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_25380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560919.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25380"/>
    <dbReference type="EnsemblBacteria" id="BAJ64564">
        <property type="protein sequence ID" value="BAJ64564"/>
        <property type="gene ID" value="ANT_25380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25380"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_0"/>
    <dbReference type="OMA" id="FKIHTFS"/>
    <dbReference type="OrthoDB" id="1558246at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="479" mass="51330" checksum="4AC025EAF76BA3CF" modified="2011-04-05" version="1">MDQKQRNRILLVLFFGVLMGALDIAILGPALPSIRKQFAVDERTLAWMFSSYVLMQLISTPWMAKLSDLYGRRWIYMLDIGLFALGSLLVALAPAFWVVLLGRAIQGFGAGGIFPVASAVIGDTFPPEKRGSALGMIGAVFGLAFLIGPLLGGVVLALASWHWLFLINLPIALAILISASRLLPVTRPAQTSRLDSGGLVLLSLFLISLTIGINQLDSSQFLSSLLQVQVGGLFGIALILLAVLIRYEQRVEAPLLPARLFNRRQLGLAYGLSWGAGFTEASLVFVPLMAVSGLASQGITEKNATWLLIPAVLAMVVGAPLSGRMLDRFGSRAVVVTGTFVMSLGFLMLSLLGSSLFWFVFSGLWIGLGLSALLGAPIRYIMLNEALPEERSLAQGIVTLFSSTGQLIGSAFMGALAASFGKADAFSGYRAAFVFVLFISLVMLGSATLLKKRQEELSRERTHANPIGIAQNEDAPAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ8</accession>
    <name>E8MZQ8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_25800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560961.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25800"/>
    <dbReference type="EnsemblBacteria" id="BAJ64606">
        <property type="protein sequence ID" value="BAJ64606"/>
        <property type="gene ID" value="ANT_25800"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25800"/>
    <dbReference type="eggNOG" id="ENOG502Z9ZQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835871_0_0_0"/>
    <dbReference type="OrthoDB" id="437508at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="38053" checksum="B164263D9C30493E" modified="2011-04-05" version="1">MAQLQPLRIHGVWLGIEEAEELRFPSAADCNSPCWWKDYRLHVLTSTGHPVLSAGRDLYHLERVGEITFTAFRDGGRWIESVFLDEDGTLYGWYHNEPAHLIGEEYQKGRQFPLTAPMIGAVVSHDNGKTWDDLGIVLNGGPETLNLEQHNYWFAGGNGDFSVLLDRQQGYFYFLFGTYYRDVTQQGISIARLRFEDRACPVGRVWKWYEGEWSQPGLLGKVTPVIPVQADWYSPNPDTFWGPSVHWNRVLQQYVILMNRAVDPRWAQDGIYISFTPDLSQPHLWTPPVKILDERGWYPEVIGLEPGDTDRDAGASARLFIHGVSRYILHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZR5</accession>
    <name>E8MZR5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_25870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560968.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25870"/>
    <dbReference type="EnsemblBacteria" id="BAJ64613">
        <property type="protein sequence ID" value="BAJ64613"/>
        <property type="gene ID" value="ANT_25870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25870"/>
    <dbReference type="HOGENOM" id="CLU_1248494_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="221" mass="24872" checksum="416313C43E8A505C" modified="2011-04-05" version="1">MSENENLPPEPALSPEQPAPEPVKAVKLEAQKPQQKPKGSWLGRFFRHILSAETRTGRIVRPVLRVVGFIVAFYALGVLTVYLLMVQPARAEIRTLQETLARTTVELRDTQDKLQKVEKEVLDARKAEARSALLEGLYPVTLARLYVADRKISDARAALNQAEEVLKKAYPILETQKLADPKTLSTLIELTRADLGRDTRLAEQDLERLTSEILLTVEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS4</accession>
    <name>E8MZS4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lipA</name>
        <name evidence="8" type="ordered locus">ANT_25960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560977.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25960"/>
    <dbReference type="EnsemblBacteria" id="BAJ64622">
        <property type="protein sequence ID" value="BAJ64622"/>
        <property type="gene ID" value="ANT_25960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25960"/>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_0"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="1184806at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="63"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="35110" checksum="B7BBB9B146E367A2" modified="2011-04-05" version="1">MVDATRDRVDPQKMDTTPIRRPSWIRVRAPSGETYEWLQKLMRQKALHTVCEEAGCPNMGECWGSGTATFLMLGDVCTRTCGFCDIKRGKPAVLDFLEPERVAQAVKAMNLKHAVITSVNRDDRRDGGAPIFAMVIQRIREIHPGCSIEVLIPDFKGSAEALRIVMNARPEILNHNVETVPRLFKLVQPQDRYEWARATLTHAKMMDPDVLTKSGIMVGLGETIDEVKAVMEDLRSWGVDILTIGQYLQPSRQHLPISRYYTPEEFEELREFGYQIGFKWVESAPLVRSSYHAAEQVRVLSAVHRQLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZS8</accession>
    <name>E8MZS8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FtsK/SpoIIIE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_26000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26000"/>
    <dbReference type="EnsemblBacteria" id="BAJ64626">
        <property type="protein sequence ID" value="BAJ64626"/>
        <property type="gene ID" value="ANT_26000"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26000"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260409_0_0_0"/>
    <dbReference type="OMA" id="WEWMKWL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="476"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="828"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="500"/>
            <end position="507"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="846"/>
            <end position="853"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ64626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1314" mass="149344" checksum="D1D18793401F9D23" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>E8N009</accession>
    <name>E8N009_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03100"/>
    <dbReference type="EnsemblBacteria" id="BAJ62344">
        <property type="protein sequence ID" value="BAJ62344"/>
        <property type="gene ID" value="ANT_03100"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03100"/>
    <dbReference type="eggNOG" id="ENOG50325GN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1089420_0_0_0"/>
    <dbReference type="OMA" id="TAGFGFW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="261" mass="29048" checksum="DE5C392D33BEA21E" modified="2011-04-05" version="1">MKIILGTSLFVQISGVGKVVPLTPSQLPVGARHGWHLSIPAGDGRAYRLAQIEQGPFRTRTEFPLIPPVEWTVWARVSAGDLPGTWGFGFWNEPFSAGLGLRGMRRALPVFPNAAWCFYASPPSFLSLRDDQPGRGWMGMVFSSPTTSPLAWLPALPLLAGLLFPATRRGLRRLARRWIHDQAVILPVDVTAWHRYTLRWEHQRVSFEVDGTWSAALPFAPRGKMKALAWIDNQMAYFDLQGNLGSGILPNPAAWLEIAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N051</accession>
    <name>E8N051_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558783.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03520"/>
    <dbReference type="EnsemblBacteria" id="BAJ62386">
        <property type="protein sequence ID" value="BAJ62386"/>
        <property type="gene ID" value="ANT_03520"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03520"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_3_0"/>
    <dbReference type="OMA" id="PVPLYQA"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="137" mass="15628" checksum="83590570D96E18B4" modified="2011-04-05" version="1">MRTKKVKEESIFETQAGVFKLLAHPARLKILALLREGEECVCHMEAMLGYRQAYLSQQLALLREAGVLEMRREGWNVYYRVARPEVYAIIDAAHSVGGSLDDLRRWEEKKKTCECPKCCRARGETPSGEETPLTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N071</accession>
    <name>E8N071_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_03720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558803.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_03720"/>
    <dbReference type="EnsemblBacteria" id="BAJ62406">
        <property type="protein sequence ID" value="BAJ62406"/>
        <property type="gene ID" value="ANT_03720"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03720"/>
    <dbReference type="eggNOG" id="COG1524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039939_1_0_0"/>
    <dbReference type="OMA" id="LMNQLRW"/>
    <dbReference type="OrthoDB" id="191097at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="432" mass="48679" checksum="4D9A1AA753178518" modified="2011-04-05" version="1">MKNAVAEGLSEIERLQRQVFPSGSEWFFPHYAGYSLVNLPASIFQWLGADAPAALRPPLAHPAFQQWNTRFDTVILILVDGIGLDWMQNTLERASRDEDLRFWAHLPAESVLAPLTSVVPSTTATALVSLWTGALPAEHGVIGYELFLKEYGILTNMITFQPAVFGEGNATLRLAGFNPETFLPVPSIGRALNEQGVGVQVLLHRSIARSSLSQMLYAGAEIFPVGSPGDLFVTLEQVVTQRTPYPRYIHAYWGAVDEAMHRFSPGNPRVWREWLMFTQQFALFFREMQKHSRGRTLLLFTADHGHIPTPRRAEFEVRRHPRLMDCLTMVPSGEARLPFAFVRAGKERAFQDAVAELWNGRFEVLPATEFVQTGWLGKTTPAPCLWERIGDFVILPREDYYWYFGLKENTLLGRHGGLSRAEMLTPLLGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8N082</accession>
    <name>E8N082_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26050"/>
    <dbReference type="EnsemblBacteria" id="BAJ64631">
        <property type="protein sequence ID" value="BAJ64631"/>
        <property type="gene ID" value="ANT_26050"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26050"/>
    <dbReference type="eggNOG" id="COG5433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046404_3_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="184" mass="21439" checksum="1A0484CA8C2CA46C" modified="2011-04-05" version="1">MKGNQAQIEEDIRLWFEPDVQPIPGMNFPPKDFESVTLTNKGHGRIEQRTLTVSSQLKGFLPWPHLEQVFKLERRFTSIRTGKVQKQVVYGITSLSRQDITPRQLLQMTRAYWGIENGLHYRRDVTLLEDRTRMTKGRMGQAMACINNLVLGILLGKLKFRYLPRTRRYFAAHPDEALSLITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0C6</accession>
    <name>E8N0C6_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PpiC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_26490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561029.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26490"/>
    <dbReference type="EnsemblBacteria" id="BAJ64675">
        <property type="protein sequence ID" value="BAJ64675"/>
        <property type="gene ID" value="ANT_26490"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26490"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917151_0_0_0"/>
    <dbReference type="OrthoDB" id="1540643at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007189744" description="PpiC domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="179"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="303" mass="33139" checksum="7CE841650AC84646" modified="2011-04-05" version="1">MQIRFLNVFLGGMLVLAWLAGCTPTPAAPAVTETPVPSVPLPPTAVPSPTPTPQPLVLVVNGEGVPLAEYEASLKQLQEAQAQMGLTSTPEEQRRMVLDDLIAATLLAQAAFKEGFTLDDAALEEQIAALAEQRGGMSALQNWMTRMGYDEVSFRSALRRSLAAAWMRDTIAAQVPERAEQVHARQILLMTPETAQQVLNQIRAGANFATLAFGYDLTTGGDLGWFPRGYLTQPAVEEAAFALQPGEVSEIIQTELGYHILQVLERETDRLLSPDARLTLQRKALEAWLQQARTQAQIEERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0D8</accession>
    <name>E8N0D8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_26610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561039.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64687">
        <property type="protein sequence ID" value="BAJ64687"/>
        <property type="gene ID" value="ANT_26610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26610"/>
    <dbReference type="HOGENOM" id="CLU_2550946_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="82" mass="9610" checksum="1FB12C7F15DBE863" modified="2011-04-05" version="1">MSLFLLDDTLRVSVFYDRSSEENEICLYFEEETPAVFRDSETRLPLSPVQAKTLVQALLEALQEHEKDHSYPIQESNDEHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0E1</accession>
    <name>E8N0E1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative aminopeptidase</fullName>
            <ecNumber evidence="2">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_26640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.11.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561042.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_26640"/>
    <dbReference type="EnsemblBacteria" id="BAJ64690">
        <property type="protein sequence ID" value="BAJ64690"/>
        <property type="gene ID" value="ANT_26640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_26640"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015077_1_0_0"/>
    <dbReference type="OMA" id="ERIWIKA"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="295"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ64690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="503" mass="56931" checksum="905B0F23480D9BCA" modified="2011-04-05" version="1">MRQGLNHTFKGILSILTLWILTLAGACAPIPTPTPASTATPLPVFTATPTHTSIPSPTPTPQENILSRPRYTLTAVLDYPAHSLNVQERIAYTHAAEESLSEVWLVMDALLYPGAFQMDSLQSVSGPALKDVRQERIWIKAQLKTPLQKGETLELDMAYRLNLPARVAQEGLRPQVFGWSERQTNLVDWYAYLPPYIPGEGWLAHPPGYYGEHQVYPLSDFEVNLQVLGAPAGLTIAASAPESQRGEWYTYTLEGARTFALSLSPSLTHTTRQVGTVIIHNYTFPYHQNAGERVLNTAAQALELYARLFSPYPHQHLAVVEADFLDGMEYDGLFFLSYGFYNLDNGTPAQYLVALTAHETAHQWFYGVVGNDQALQPWLDEALCTYAEKLYYETYAPEALTWWWEARVKYYQPRGYVDDSIYNPHGEAQPYRAYRDAVYLNGAVFLDELRRAMGDEAFFDFLRLYVSENQGKIASARDFFGLLRKMTSVPLEPLLQRFFQFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0N6</accession>
    <name>E8N0N6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="2">2.7.1.144</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_03970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558827.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="SMR" id="E8N0N6"/>
    <dbReference type="STRING" id="926569.ANT_03970"/>
    <dbReference type="EnsemblBacteria" id="BAJ62431">
        <property type="protein sequence ID" value="BAJ62431"/>
        <property type="gene ID" value="ANT_03970"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_03970"/>
    <dbReference type="eggNOG" id="COG4573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053334_0_0_0"/>
    <dbReference type="OMA" id="QRHFSYS"/>
    <dbReference type="OrthoDB" id="395879at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012062">
        <property type="entry name" value="GatZ/KbaZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08013">
        <property type="entry name" value="GatZ_KbaZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009264">
        <property type="entry name" value="TagBP_ald_AgaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02810">
        <property type="entry name" value="agaZ_gatZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="429" mass="47282" checksum="EC2ECC17D130CF8A" modified="2011-04-05" version="1">MMFGSPAPLLDMVTAQKQGMARGIPSICSAHPVVLSAACHLARRSGAPLLIETTCNQVNHQGGYSGMTPADFVRFLREILEREGIPPQQVILGGDHLGPYPWRKEPAETAIAQALEMVRAYVQAGYTKIHLDASMPCADDDPERPLPLERIARRAAQLCAAAEAAAGAVQPVYVIGSEVPPPGGAQGQEARLHVTTPQEAQAALDAFREAFLQAGLTPVWERVIALVVQPGVEFGVDSIHAYQREAARPLKTFIEGVPGMVYEAHSTDYQTRASLRALVEDHFSILKVGPALTFAYREAVFALEHIEREILGRQDMPLSRLSEVLDEVMLNDPRHWQGYFAGAPAEQALARRYSFSDRIRYYWHHPAAQEAVRRLLANLIETPPPLSLLSQYLPREYEMVRAGEISSHPQDLIRAHIQHTLEDYAAACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P0</accession>
    <name>E8N0P0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative alpha-galactosidase</fullName>
            <ecNumber evidence="8">3.2.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_04010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="8"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558831.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04010"/>
    <dbReference type="EnsemblBacteria" id="BAJ62435">
        <property type="protein sequence ID" value="BAJ62435"/>
        <property type="gene ID" value="ANT_04010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04010"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="OMA" id="METYSPD"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="193"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ62435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="443" mass="50133" checksum="00617AACE9976AFC" modified="2011-04-05" version="1">MTKITFIGAGSLGFTSELVRDILTFPLLEDAHIALMDIHPERLEWAKRQVEKLIAAGKRPATVSATLDRAEALKGADVVLTTILAGSTEVWRHDIEIPKKYGVDINVGDTRGPSGIFRFLRTINPMMDIVRDMEKYYPNAVLLNYTNPMAMLVSAIQKQSFITVTGLCHSVQGTAMMLARWIGAPYEEIDYVCAGINHQAWYLEYKWNGQDAYPLIRKAVTERPEVYNEEIVRNEMFLALGYYVTESSGHNSEYNWWFRKRPDLIEKYCTHGTGWNPGEYAYILKEYQRNEATWKDQVRERLEAPLTPEDLQRGEEYAAYIINALKGGEPFKFNGNVRNTHLITNLPEGACVEVPVYVDRAGFHPTHVGALPPECALLTQLSSGIEEMAVQASIAGDPTMVYRAICHDPLTASVLSLAEIRQMTNELFAVHKDYLPQFKVHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0P6</accession>
    <name>E8N0P6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_04070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558837.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04070"/>
    <dbReference type="EnsemblBacteria" id="BAJ62441">
        <property type="protein sequence ID" value="BAJ62441"/>
        <property type="gene ID" value="ANT_04070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04070"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_0_1_0"/>
    <dbReference type="OMA" id="STHEPGF"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="258" mass="28211" checksum="AC7BAC80BB97646A" modified="2011-04-05" version="1">MDIPSLSNIERQQAILALLQRQQRVKIAQICEEFAVSEATARRDLEALASQGLIQRVHGGAIPLQPAAPEPPLLERSHEQADEKARIGRLAATLVQDGETVFLGSGTTVLEIAKHLRERKGLTIITNSLPVVNLFAGMEHIQVVCLGGILRDSELSFIGHITEQALSEVRADKVFLGVRAVDLEHGLTNDYLPETMTDRAILKIGREVIVVADHTKCCRVSTAFLAPLTSMHTFITTQEADESFISALQELGVRVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0R2</accession>
    <name>E8N0R2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moeA</name>
        <name evidence="9" type="ordered locus">ANT_04230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558853.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04230"/>
    <dbReference type="EnsemblBacteria" id="BAJ62457">
        <property type="protein sequence ID" value="BAJ62457"/>
        <property type="gene ID" value="ANT_04230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04230"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_2_0"/>
    <dbReference type="OMA" id="GKPLMHG"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="188"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="411" mass="43438" checksum="E882C0591A46686C" modified="2011-04-05" version="1">MPEFLELLPPAQAWEVFRNALPSAVLPAERLAVVQARGRVTAEPVVSPENLPAFSRSTVDGYAVQARDTFGASESLPAYLKLIGEVPMGAAPSFSIRRGECALIHTGGMLPEGADAVVMLEHTQSSRPDEVEILRAVPSGENVLLAGEDVRIGEVVLPAGVRLEDAQIGGLTALGILEVNVVRQPRVGILSSGDEVIPPERQPQPGQVRDINSYSLSALVERHGGLAVRYGIVPDRPEVLRETLRHALSECDAVVITAGSSASTRDFTAAVINEMGAPGVLVHGVNVKPGKPTILGVCNGKPVIGLPGNPVSALVIARLFVVPVLRSLLGLSGEVWQSAVRAVLTVNLASQAGREDYFPVQLIRKGETLFAEPIFYKSNLIFTLARADGLVKIPASATGLGVGEEVDVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0S4</accession>
    <name>E8N0S4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_04350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558865.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04350"/>
    <dbReference type="EnsemblBacteria" id="BAJ62469">
        <property type="protein sequence ID" value="BAJ62469"/>
        <property type="gene ID" value="ANT_04350"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04350"/>
    <dbReference type="HOGENOM" id="CLU_1021744_0_0_0"/>
    <dbReference type="OrthoDB" id="2183007at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043715">
        <property type="entry name" value="DUF5656"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18900">
        <property type="entry name" value="DUF5656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="272" mass="29596" checksum="C501568C92922F4B" modified="2011-04-05" version="1">MEAHEHLPDRNRMSVVIAAVMLAYAVTPFVQIAPLILQTQLPGLFLSFTIDFSTLSSLLAAALAATGSWWLLLDHPLYPTWQNRGRHWLLPALTAWVIGVPLNTLEVGPEWWALFGLGGVFLVIVLLAEYIALDPEDVRHAPAVVGLTALSFALFLLLTVSLKATGLRLFLTFPAITLAVGLAALRTLYLRLGGVWHWKGALFITLIVGQIASALHYFPLLPLQYGLLLTGLAYALTSIVSAYEEGRTGTALWLEPAIMLGVLSLLAVLIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N0W0</accession>
    <name>E8N0W0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_04710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558901.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_04710"/>
    <dbReference type="EnsemblBacteria" id="BAJ62505">
        <property type="protein sequence ID" value="BAJ62505"/>
        <property type="gene ID" value="ANT_04710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_04710"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_0"/>
    <dbReference type="OMA" id="LMITHKF"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="266"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="521" mass="57024" checksum="2F90C3F49A94B68F" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N108</accession>
    <name>E8N108_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62553">
        <property type="protein sequence ID" value="BAJ62553"/>
        <property type="gene ID" value="ANT_05190"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05190"/>
    <dbReference type="HOGENOM" id="CLU_2986459_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="57" mass="6250" checksum="BD40CB186C88359D" modified="2011-04-05" version="1">MSDCACGGSCGCGHHTEESTVYLTREEYIARLEQYLLDLKAEIAAVEAELAELRQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N114</accession>
    <name>E8N114_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">ANT_05250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05250"/>
    <dbReference type="EnsemblBacteria" id="BAJ62559">
        <property type="protein sequence ID" value="BAJ62559"/>
        <property type="gene ID" value="ANT_05250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05250"/>
    <dbReference type="eggNOG" id="COG3346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047737_0_0_0"/>
    <dbReference type="OMA" id="MAYAVQW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ62559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="261" mass="29218" checksum="37EBA22217551EA9" modified="2011-04-05" version="1">MKTTVMPASTPKTHAFFSLRWLGTTLLVLMAVAVMVRLGVWQLDRLGQRRAQNALILQNASAPVLDLNRALIQGKTDWKSQAFRLAEASGVYLHEEEILLLNQVWEGQPGYHLVTPLRISGTDAVILVDRGWIPLNQADEAARAVYHLNGEVRLQGRLMPSQAEPRWGGGGDPQIPEGGRLPAWKWLNVERISQQVSGNVLPVYLLELSENATLTLPYRADTSIEVSEGSHLSYALQWFSFALILLIGYPFYVRKQLSQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N144</accession>
    <name>E8N144_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ordered locus">ANT_27610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561135.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27610"/>
    <dbReference type="EnsemblBacteria" id="BAJ64787">
        <property type="protein sequence ID" value="BAJ64787"/>
        <property type="gene ID" value="ANT_27610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27610"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_0"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="256"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="407"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ64787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="495" mass="54640" checksum="495910D4C8558484" modified="2011-04-05" version="1">MAKYAAALDQGTTSTRFMIFDHHGQVVAMDQKEHEQIYPKPGWVEHNPLEIWERTQEVIEGALRKSGISPKEIAAVGITNQRETTLLWEKATGKPVYNAIVWQDTRTDKICNDLAAEGGQDRLRPKTGLPLATYFSGPKIRWILENVPGVRERAERGEILFGTMDTWIIWNLTGGVHVTDVTNASRTLLMNLQTLDWDDELLDLLGIPRAILPQIRSSSEVYGYARGALEGVPVAGDLGDQQAALFGQACYDPGEAKNTYGTGCFMLLNTGTTPVPSQSGLLTTLGYKIGNAPAVYALEGSIAITGALVQWLRDNLKMIENSRDIEGLARTVEDNGGIYFVPAFSGLFAPYWRSDARGIIVGLTRYINRGHIARAALEATAYQTREVLDAMNRDSGITLTALKVDGGMVYNQLLMQFQADILGVPVIRPKVAETTSLGAAYAAGLAVGFWETFDELRANWGKDTEWHPQMSPELREKLYAGWKKAVERTFGWVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N151</accession>
    <name>E8N151_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_27680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561142.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27680"/>
    <dbReference type="EnsemblBacteria" id="BAJ64794">
        <property type="protein sequence ID" value="BAJ64794"/>
        <property type="gene ID" value="ANT_27680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27680"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_3_2_0"/>
    <dbReference type="OMA" id="WIANYGM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="333" mass="36928" checksum="8AD3E5ECE031F834" modified="2011-04-05" version="1">MSGNWVPPRVNRVLNAKNLSFFLLGVLILIFLLRQIDLKELRDQILGVRWELFLAGAGVYFLKSCLRAVRLNRISADLSLPYLKTLRLSLATSLATQILPFKLGELSYVYLLKQEKNAPAAQGLSALIVIRLMDLLAIGVLYLAVALALRSPQSGVQMMQALIFIGLLGAGMGLLMALSRLAPPVLEKVKAKSFPKENFLLRLIEWVEKFFRYFQAYRPLQFAQWMGLALLEWIANYGMFHLLLLGMSVPVTFFQTATAVTFAAVASALPVNAVGSFGSQEAGWTAALLLVQVDRQTAITTAFSTHILTLAYIAFFGALAWLSYLLRLGSRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N157</accession>
    <name>E8N157_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ordered locus">ANT_27740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561148.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_27740"/>
    <dbReference type="EnsemblBacteria" id="BAJ64800">
        <property type="protein sequence ID" value="BAJ64800"/>
        <property type="gene ID" value="ANT_27740"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_27740"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_1_0"/>
    <dbReference type="OMA" id="NRVELMW"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="178"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="409" mass="44898" checksum="9980E13DC04DBC94" modified="2011-04-05" version="1">MNRGVVLSETSNLSVRHQWGKFFQGLFLFSTVIGLIVLGILILTVVDKTFTLVAVTNKVDPATLADRPLEELSAEELRQILRDKLRPARLRTIERDMGPIAQMGEADLTALIMAEIVKPTTRASYPLFQSLTRRAEIEAEIRKEYPDAQIYFKAWLSWDFLQRSMATNPDLAGVRQAIKGSLLIILITILFAFPIGVGAAIYLEEYADKRNRINRILQTNIENLAGVPSIIYGILGLAVFVRALAPITSGAAFGMDAGSGRTILSGGLTMALLVLPILIISSQEALRAVPNSLREASFAMGATRWQTIWHHVLPYALPGILTGTILAVSRALGETAPLILVGASSLINKDPQSVFSFFTALPFQIYNWTVRPQPEFRNIAAAAILVLLAVLLSLNATAIVLRNRLSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N195</accession>
    <name>E8N195_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_28120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561184.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28120"/>
    <dbReference type="EnsemblBacteria" id="BAJ64838">
        <property type="protein sequence ID" value="BAJ64838"/>
        <property type="gene ID" value="ANT_28120"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28120"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835872_0_0_0"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228590" description="LysM domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="332" mass="34674" checksum="EE8253B40DFE9D9C" modified="2011-04-05" version="1">MKAFWKVVLVCVLSLNGLLFLRSPSQAQAGSPEELIAAVNALRAQRGLPALTVSTALMSAAQSHAEYQASIQTITHTGAGNTRPKDRAIAAGYGGGAVVFVSENIAGGTNLSVQDAITLYWSDDVHMNTMLNPNFQHIGAGVAFSGEMVYYTLVVGSTSGTSNALNTLPALNTPTLTLTPPPVPASAQETVTPPAAAISTPDESQMYEVQPGDTLWGIAVTYQVSMDDLKRWNNLPATPNLWPGDRLIVQPSFTPAPSATETPLPTVTPTVAFTATPMPTIIVPVTAITLTPTPETAPLSSGSSPLLFIGIGLIVLSVLGMILLFVGKLQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1C3</accession>
    <name>E8N1C3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="10" type="ordered locus">ANT_28400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561211.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_28400"/>
    <dbReference type="EnsemblBacteria" id="BAJ64866">
        <property type="protein sequence ID" value="BAJ64866"/>
        <property type="gene ID" value="ANT_28400"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28400"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_2_1_0"/>
    <dbReference type="OMA" id="NIQLFTF"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="BAJ64866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="90" mass="10387" checksum="3DEFF469B9984254" modified="2011-04-05" version="1">MSVEKTPNLILVYDIVDDRKRTKIADVCLDYGLDRIQYSAFVGWLIPAKQQELFTKIRRILGKSPGNVQLLPICADDWKKRRVIDQPDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1D0</accession>
    <name>E8N1D0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_28470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="BAJ64873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="BAJ64873">
        <property type="protein sequence ID" value="BAJ64873"/>
        <property type="gene ID" value="ANT_28470"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_28470"/>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122744_0_0_0"/>
    <dbReference type="OMA" id="LHGRCGY"/>
    <dbReference type="OrthoDB" id="1806242at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ64873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="127" mass="14063" checksum="799F42C04C04A66B" modified="2011-04-05" version="1">MILVNFSHPLSNDQMAQLQALLGAPIERVVEVHSQIEPDQPLAPQVTAMVDQAGLTLEEWQNAPIIVNPPSLNFSAVLLVAELHGRMGYFPACVRLRPVNGAIPPRFEVAEVLNLQLQRDAARRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1J1</accession>
    <name>E8N1J1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_05620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558992.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05620"/>
    <dbReference type="EnsemblBacteria" id="BAJ62596">
        <property type="protein sequence ID" value="BAJ62596"/>
        <property type="gene ID" value="ANT_05620"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05620"/>
    <dbReference type="eggNOG" id="COG4745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423151_0_0_0"/>
    <dbReference type="OMA" id="NEWDSMT"/>
    <dbReference type="OrthoDB" id="1639858at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="647" mass="73004" checksum="4C28047627363E6E" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1N5</accession>
    <name>E8N1N5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">mscL</name>
        <name evidence="11" type="ordered locus">ANT_06060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559035.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06060"/>
    <dbReference type="EnsemblBacteria" id="BAJ62640">
        <property type="protein sequence ID" value="BAJ62640"/>
        <property type="gene ID" value="ANT_06060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06060"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_2_3_0"/>
    <dbReference type="OMA" id="AWIIFLM"/>
    <dbReference type="OrthoDB" id="1863650at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="BAJ62640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="147" mass="15778" checksum="4BE25352F9FDE578" modified="2011-04-05" version="1">MWKEFKEFALRGNVIDLAVGIIIGGAFGKVVSSLVNDIIMPPIGLLLGKINFSDLFLDLSGTHPASLSAARDAGVPVLAYGSFIQSLVDFLIVAFAIFLLVRAVNRLRVLKPEPAAPPAEPTTKECPYCLSTIPIKATRCPHCTSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>E8N1R5</accession>
    <name>E8N1R5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559065.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06360"/>
    <dbReference type="EnsemblBacteria" id="BAJ62670">
        <property type="protein sequence ID" value="BAJ62670"/>
        <property type="gene ID" value="ANT_06360"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06360"/>
    <dbReference type="eggNOG" id="COG2089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040465_0_0_0"/>
    <dbReference type="OMA" id="WKRMEFT"/>
    <dbReference type="OrthoDB" id="674753at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006190">
        <property type="entry name" value="AFP_Neu5c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036732">
        <property type="entry name" value="AFP_Neu5c_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51269">
        <property type="entry name" value="SSF51269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50844">
        <property type="entry name" value="AFP_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFP-like" evidence="1">
        <location>
            <begin position="296"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="355" mass="39471" checksum="BC6131E0328B573F" modified="2011-04-05" version="1">MDIQIGNRLVGLNHPTYFIADIAANHDGSLERAKQLIRLAKEAGADAAKFQNFRAPKIVSDYGFKALGGQKSHQATWRKSVFEVYQDASIPFEWTYELKAVCDEVGIDYFSSPYDFEATDFLVPYMPAIKIGSGEITWHEALEHIARKGLPVILATGASDIGEVAAAVRLILSINKQLVLMQCNTNYTASLENFNHVHLNVLKTYGLMFPDVVLGLSDHTPGHAAVLGAVALGARVIEKHFTDDNNREGPDHKFAMNPDTWAQMVENTRQLERALGSADKFVAENEQETVVLQRRCLRAARDLPAGTVITREHLDVLRPAPRDAIMPYDIPRVLGKRLIVDKVAGQELRWTDLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N202</accession>
    <name>E8N202_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561293.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64949">
        <property type="protein sequence ID" value="BAJ64949"/>
        <property type="gene ID" value="ANT_29230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29230"/>
    <dbReference type="HOGENOM" id="CLU_1232933_0_0_0"/>
    <dbReference type="OrthoDB" id="2159077at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003225402" evidence="2">
        <location>
            <begin position="19"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="224" mass="23410" checksum="FCA570252C2E4F7B" modified="2011-04-05" version="1">MRRVVLFFALMLMLTACSGFPLPGAPAQPAPTNPPPQIAPTATPQVVRTLPPLITPTQPQSPEAATPESSPAPSAPAPSPTPAFVLQAGSPAYLPAFTHPEAGCAWVGIAGQVFNSAGLPQDNIVVVVKGLFNGKAVDALALSGLAKAYGAGGYEIQVGTASATTSEALTIQLLNDKFEPLSPVYPVQTFDDCQKNLILMNFQSTENQFWLYLPAILNETSEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N206</accession>
    <name>E8N206_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">ANT_29270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29270"/>
    <dbReference type="EnsemblBacteria" id="BAJ64953">
        <property type="protein sequence ID" value="BAJ64953"/>
        <property type="gene ID" value="ANT_29270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29270"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_1_1_0"/>
    <dbReference type="OMA" id="FVMRTWM"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="27"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ64953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="277" mass="31564" checksum="AFFB008591BC1A9B" modified="2011-04-05" version="1">MSKALTLLADLVNVPKTMATLIRYREAIRILTWRDFRARYRGSIFGILWAVAQPLLMMLAYTLVFSYFLKVRFGSSDSPTVFAVYLLCGLVPWNAFAEGINSACSLIRISPNLVKKVVFPVEVLPVNLTLVTMIQQLIGLGLLLMLVLVVGNGLTLWILLLPFFLLLQFMLQTGISWLLASLSVFIPDFRQATSLLTLLLMFITPIFYPETLIPERFRFLVTLNPMAQIVGMYRRVLMEGLPPTLEQILWAGGMSLLFWMVGFVWFNRTKHAFPDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N235</accession>
    <name>E8N235_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_29560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_29560"/>
    <dbReference type="EnsemblBacteria" id="BAJ64982">
        <property type="protein sequence ID" value="BAJ64982"/>
        <property type="gene ID" value="ANT_29560"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_29560"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_424329_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="532"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ64982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="645" mass="71307" checksum="C9AC3560CE412EB8" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B0</accession>
    <name>E8N2B0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD-GYP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_30310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561398.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30310"/>
    <dbReference type="EnsemblBacteria" id="BAJ65057">
        <property type="protein sequence ID" value="BAJ65057"/>
        <property type="gene ID" value="ANT_30310"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30310"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_0"/>
    <dbReference type="OMA" id="RPYKKGY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="240"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="437" mass="49184" checksum="76243F4617AC6162" modified="2011-04-05" version="1">MAALIPPGWRALLVPMRAGQEQLGILMVVVEAPRKFSEAEVNLVQTAGDIIGSVLHRAQLDAEVRTRLEQLTSLHEIDTAISSSHNLKATANILLQQCLRMLKVDAALLYEFDPVNLHLDCVATLGLNTARLEHIRVRAGETVVGKAMLEGVLTGGNMEWQTLPAGTHDRLMWEKGFRQIFAVPLVSKSRVVGVLEVCRRKTPPATKEWLELLNTLAGQAAIAIENARLFEDLQRTNAELMVAYDATLEGWALALGLRDSNTEDHTRRVVEATVELGKAMGLSEVDLIQLRRGAILHDIGKLGIPDTILLKPSFLTEEEREIMRRHPLYAREWLSRIPYLRQAMDIPTYHHEHWDGSGYPYGLRGEQIPLGARIFSVVDVWDALSTDRPYRKAWPRDKVLHYIRAQAGLQFDPQVVKVFLQSIERIEKILEKGHFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B6</accession>
    <name>E8N2B6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_06880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559116.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06880"/>
    <dbReference type="EnsemblBacteria" id="BAJ62722">
        <property type="protein sequence ID" value="BAJ62722"/>
        <property type="gene ID" value="ANT_06880"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06880"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515495_0_0_0"/>
    <dbReference type="OMA" id="FDLCFFD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="301"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ62722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="528" mass="59021" checksum="292E6E5B139A2976" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2B7</accession>
    <name>E8N2B7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_06890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559117.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_06890"/>
    <dbReference type="EnsemblBacteria" id="BAJ62723">
        <property type="protein sequence ID" value="BAJ62723"/>
        <property type="gene ID" value="ANT_06890"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_06890"/>
    <dbReference type="eggNOG" id="ENOG50336D4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592427_0_0_0"/>
    <dbReference type="OMA" id="WFLWIAG"/>
    <dbReference type="OrthoDB" id="2096018at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="171" mass="18687" checksum="861E434131C6D78B" modified="2011-04-05" version="1">MEPTSLPDAQALAALQKRLNLERRFRSGVDWFFWIAGLSLINTIVFVLGGSMTFVVGLGLTQVVDAIGYVIAQETSGTTTTIIRAVAFVISLCISGIFVLFGVLGRKRQRWAIITGMVLYLLDGLIFLAFADFLPALFHAIALFGLWGGFSALRELIKLDQPLTPPTIEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2J2</accession>
    <name>E8N2J2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_07640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07640"/>
    <dbReference type="REBASE" id="32149">
        <property type="entry name" value="AthUNI1ORF7640P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="BAJ62798">
        <property type="protein sequence ID" value="BAJ62798"/>
        <property type="gene ID" value="ANT_07640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07640"/>
    <dbReference type="eggNOG" id="ENOG502Z8N2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095681_0_0_0"/>
    <dbReference type="OMA" id="HHIMCSI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010324">
        <property type="entry name" value="DRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041368">
        <property type="entry name" value="DRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043025">
        <property type="entry name" value="DRP_PD-(D/E)XK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06044">
        <property type="entry name" value="DpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17726">
        <property type="entry name" value="DpnI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DpnI_C" evidence="1">
        <location>
            <begin position="186"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ62798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="256" mass="29480" checksum="DB4551E9D84D0B02" modified="2011-04-05" version="1">MDLDLSKYLHLTTQYTSASQRARVLTEVWVAENFLCLTCDRKISALPANTRACDFQCESCNERYQLKSSSKNLSNRILGAEYHTTLTTVRLDRHPSLILLQYNRDNFSVANLKILHGSWITENVVIPRSPLRPPARRAGWQGCIIDLRSIPASAFVEIIKDGQILPQVVIKNHWQTARAISSFSNSQRTWLSLVLHVVDNLPANFSLQDIYKYEEKFIQYHPKNKNIRAKIRQQLQIARDLGLIKFLEPGVYQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2M1</accession>
    <name>E8N2M1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">ANT_07930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559220.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_07930"/>
    <dbReference type="EnsemblBacteria" id="BAJ62827">
        <property type="protein sequence ID" value="BAJ62827"/>
        <property type="gene ID" value="ANT_07930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_07930"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="OMA" id="FYRHQTQ"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="317"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ62827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="411" mass="43904" checksum="2C473FC2F42E7E4A" modified="2011-04-05" version="1">MMFSEVLKIAWQSLMANKLRSFLTMLGVIIGVAAVIIMVAISAGTEATISEAINGLGSNLVFISSAVSRGGPAGGPQTMRGGLVYDDMTAIRERISGVAGVTVEQQTAVTVKYENTSLEDVMLVGATPDFPTVRDVRVAEGRFYNDTELERASKVVVLGKTVAEELFGEADPIGQTVTVNSIKLTVIGVMAEKGLVAGVDFDQQIYVPITLVFKKFMPAQFARIMGDRVRQIIVSVDAHADMDKVIEQITYLLANRHEVTTDSLDFTIRTQADIIATQESTTESFRTLLAWVAGVSLIVGGIGIMNIMLVSVTERTKEIGLRQAVGAAPGDIQIQFLMEALLLSLVGGLLGVLAGVGGAYLFERLGGMRTVVLPYSIGISFLSAALVGVFFGFLPAKQAADLDPIVALRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2T4</accession>
    <name>E8N2T4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_30580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_30580"/>
    <dbReference type="EnsemblBacteria" id="BAJ65084">
        <property type="protein sequence ID" value="BAJ65084"/>
        <property type="gene ID" value="ANT_30580"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_30580"/>
    <dbReference type="HOGENOM" id="CLU_3057961_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="53" mass="5943" checksum="F319DD9E69B4A0A8" modified="2011-04-05" version="1">MLTTGVERGIVICESPEKVAFLIDEPSQDMLSSIIPAIIFAFILDLNKRRTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N321</accession>
    <name>E8N321_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">menA</name>
        <name evidence="7" type="ordered locus">ANT_31450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561512.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31450"/>
    <dbReference type="EnsemblBacteria" id="BAJ65171">
        <property type="protein sequence ID" value="BAJ65171"/>
        <property type="gene ID" value="ANT_31450"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31450"/>
    <dbReference type="eggNOG" id="COG1575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_1_2_0"/>
    <dbReference type="OMA" id="QWIEGAR"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ65171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="304" mass="32368" checksum="CD4E9912EE6DBAE8" modified="2011-04-05" version="1">MTQAQLSPTSPLRVWWMAARPRTLPAAIAPVIAASALAFYDGMFRWDAALAALLGALFLQIGANLANDVYDYQKGADTSQRVGPTRVTQAGLLTSAQVKMGMAVVFGLAALCGVYLTLISGWLVIAIGVLSIISAVLYTAGPYPLGYNGLGDLFVYLFFGLAAVAGTYYVHTRTVSLAAVALSVPIGALVVNILVVNNLRDIPTDTLSGKRTLAVRFGADWTRKEYLSLTVLAYLAPLLMALSGLVSPWILLCWLSIPKAIPLVRQIYTESGRALNLTLAGTGQLELLYCLLMALGLALAKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N324</accession>
    <name>E8N324_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_31480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561515.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31480"/>
    <dbReference type="EnsemblBacteria" id="BAJ65174">
        <property type="protein sequence ID" value="BAJ65174"/>
        <property type="gene ID" value="ANT_31480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31480"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899081_0_0_0"/>
    <dbReference type="OMA" id="FVPGRIW"/>
    <dbReference type="OrthoDB" id="1473120at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="309" mass="35167" checksum="176577B168702EC0" modified="2011-04-05" version="1">MIKKWVRILGLGIGLTIFLSQIYQSILSISTLSIRMDWGWMILGFLAMFLLIALQIFIWKQILNAMEIPLEYLQIAKGYTLSLIPRYIPGSVWGYLNRSEWLNEQYHVPVSQGNVSSLLEVLQVILTAFMALIIFSGVLSGFSFWRFSLVLLLVLLLPILVWKILSLPSILRNRWIPFKIRLSNWLIAVYSGLIQWVILGLSTISLLFGIQGVFPFESLSLQKGALVSFCYTTSWLAGFFVLFIPGGMGIRELSLSFFLTHLVNVPVGFSTWIAVLSRLLYSLAELTWIFLSLHLKSSPQKRINQKGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>E8N345</accession>
    <name>E8N345_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_31710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31710"/>
    <dbReference type="EnsemblBacteria" id="BAJ65195">
        <property type="protein sequence ID" value="BAJ65195"/>
        <property type="gene ID" value="ANT_31710"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31710"/>
    <dbReference type="HOGENOM" id="CLU_3039866_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ65195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="54" mass="5675" checksum="4426BD4F2C7AC0D4" modified="2011-04-05" version="1">MGPRRGDVIRIPPSPPFFGIEVPPWVPAGGCYSNPTLSAEDIAQPLLGDVCLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3I4</accession>
    <name>E8N3I4_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">prfA</name>
        <name evidence="7" type="ordered locus">ANT_09640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559389.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09640"/>
    <dbReference type="EnsemblBacteria" id="BAJ62998">
        <property type="protein sequence ID" value="BAJ62998"/>
        <property type="gene ID" value="ANT_09640"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09640"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_0"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="6">
        <location>
            <begin position="61"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ62998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="357" mass="40392" checksum="974654FD7EDBD88B" modified="2011-04-05" version="1">MLEKLIAIESRFEELNRLLEENAGDYQKVIELSKERADLEPIVEKAQEYRTVLKQIEEARTLLESGDEELRELAEADLETLEPRQEVLEKELKTLLIPKDPRDERNVIVEIRAGTGGEEAALFAGDLFRMYSRYAEKRGWSVEIISQNETGIGGYKEIIFMVKGKGAYSRLKYESGVHRVQRIPVTESSGRIHTSTATVAVLAEVDEVDINIPDSDLEIEVYRSAGAGGQNVQKNSTAVRITHLPTGIVVACQDERSQLQNKLRAMSILRAKLYEIEEQKRQQELDATRRSQVGTGERAEKIRTYNFPQSRVTDHRIGISSYNLPAVLDGEIDLFIDELALRSETERLATGADEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J8</accession>
    <name>E8N3J8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_09780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09780"/>
    <dbReference type="EnsemblBacteria" id="BAJ63012">
        <property type="protein sequence ID" value="BAJ63012"/>
        <property type="gene ID" value="ANT_09780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09780"/>
    <dbReference type="eggNOG" id="COG1833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115699_0_1_0"/>
    <dbReference type="OMA" id="KSIRWHV"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd10441">
        <property type="entry name" value="GIY-YIG_COG1833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002837">
        <property type="entry name" value="DUF123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37460">
        <property type="entry name" value="PTHR37460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01986">
        <property type="entry name" value="DUF123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="176" mass="19351" checksum="D07B1D49A1C396FF" modified="2011-04-05" version="1">MIPANPFPEEPGTYFLAYHLRASGEYRIGRFASAFLPEGIYFYTGSAWTRGGLCARLSYHLRLPEHPHWHLDWLKPHLNLLGAGWQVEVRAECQWAQALIAHPQASVPIPGFGASDCRQHCPAHWVFFGTMGGHHAWRKIVEETLAQLLDAPSGFWSGDIAGSMDESPGAGSSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3J9</accession>
    <name>E8N3J9_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lspA</name>
        <name evidence="8" type="ordered locus">ANT_09790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09790"/>
    <dbReference type="EnsemblBacteria" id="BAJ63013">
        <property type="protein sequence ID" value="BAJ63013"/>
        <property type="gene ID" value="ANT_09790"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09790"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_2_2_0"/>
    <dbReference type="OMA" id="IEFGMVF"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="15820" checksum="6623902268EA5744" modified="2011-04-05" version="1">MWAPWDWLMPYARFVNWYNTGVAFGLFQGKGDWFIFLAILVAVFIVLYYPRVPDQDWSLRLAMSLQLGGALGNMIDRLKQGFVTDFISVGTFPVFNIADSSITIGVIILLLGVYLQERRERRRAQESQEIPPQNSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K3</accession>
    <name>E8N3K3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD-GYP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_09830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559408.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09830"/>
    <dbReference type="EnsemblBacteria" id="BAJ63017">
        <property type="protein sequence ID" value="BAJ63017"/>
        <property type="gene ID" value="ANT_09830"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09830"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_379784_0_0_0"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="536"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="729" mass="82646" checksum="65750DE832D40E4D" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3K5</accession>
    <name>E8N3K5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_09850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559410.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09850"/>
    <dbReference type="EnsemblBacteria" id="BAJ63019">
        <property type="protein sequence ID" value="BAJ63019"/>
        <property type="gene ID" value="ANT_09850"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09850"/>
    <dbReference type="eggNOG" id="ENOG502ZDYJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217771_0_0_0"/>
    <dbReference type="OMA" id="FANGPWT"/>
    <dbReference type="OrthoDB" id="2073296at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="227" mass="25579" checksum="DD139A83AC6912FA" modified="2011-04-05" version="1">MDELIRFLQQYESGVYFLAGGVGLIYLWRLLTAWEEYRKAVFGIEREIARRKILSALTIMGLMVLMVFAEFVLVSFVVPSYLEKPVFQTPTLNLLETPQVSLSTPQLSTPTPSNLIMTVAPSQEGCIEGQIEWVSPRPGDELEKTVELKGTVNVPNLGFFKYEYASVNSEDWVTIAADNRPKVNALIGYWDVSQIVPGDYRLRLVVTDNQNNVFPACVIQVRVINSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3L3</accession>
    <name>E8N3L3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_09930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559418.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_09930"/>
    <dbReference type="EnsemblBacteria" id="BAJ63027">
        <property type="protein sequence ID" value="BAJ63027"/>
        <property type="gene ID" value="ANT_09930"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_09930"/>
    <dbReference type="eggNOG" id="COG1300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577022_0_0_0"/>
    <dbReference type="OMA" id="DWRILVP"/>
    <dbReference type="OrthoDB" id="1358913at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="473" mass="52500" checksum="035C9895D75BC203" modified="2011-04-05" version="1">MWTELRPVWILMRRELKDQLRDWRIILPILVLALGFPFIMNWTVREMLDFTSEYGATIVADRLVPFLFMVVGFFPISVSLVIALESFAGEKERNSIEPLLNTPLLDWQIYLGKLLASTLMPLLGSYLAMLVYLLGLVSRGIPLPPPVIMTQIFLLTTIQAVMMVSGAVVISSQATSVRAANLLSSFIVLPVAFLIQWEALVMFWGNEMTLWWVLVGTLVIALLLSRVGVSHFNREKVLGREIDVLKPAWAWQVFWKTFKGNAYSVREWYSVSVFPTLRRLFVPALMVLAISAVGLGIGAYMLKEFPVLLTASKLQEQSLPNIERLRQTLLGNESGMFLLIFWQNLRVLLLSMVLGIFTFGVVGTLPIMGTMAVVGFLGAFLSVNQVALSPILTMILPHGIFEVPAAILATAAVLKIGATLATPARDLTIGEVFLKAIADWAKIMVGLVIPLLVVAAFVEAFITPRLVLMVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3T0</accession>
    <name>E8N3T0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proS</name>
        <name evidence="9" type="ordered locus">ANT_10600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559484.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10600"/>
    <dbReference type="EnsemblBacteria" id="BAJ63094">
        <property type="protein sequence ID" value="BAJ63094"/>
        <property type="gene ID" value="ANT_10600"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10600"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_0"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="40"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="BAJ63094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="478" mass="54497" checksum="40F9C0A8C5A91B73" modified="2011-04-05" version="1">MSDEKLTPQSENFSEWYNQIVLRADLADYAPVRGCMVVKPYGWALWENIQQALDKRFKATGHVNAAFPLFIPMSFLEKEKEHVEGFSPELAVVTVGGGETLEEPLVVRPTSETIIGYMYSKWIRSYRDLPILINQWGNVVRWEMRTRLFLRTLEFYWQEGHTAHATREEAIEETMRMLDTYYRFAIEEAAVPVIPGRKSQTEKFAGAEMSMTIEAMMRDTKALQSGTSHFLGQNFARAFDIRFLDQNNELQYAWTTSWGLSTRFIGAIIMTHGDDQGLILPPRLAPIQVVIVPIYRDDAERSLVMPVVDRLEQELREAFRVHVDRRDGVTPGFKFNDWEMRGVPLRLEVGPKDVEKNSVALARRDRPGKAGKSFVSQEGLTQTIADTLKDIHQSLLDRAIAFRDSHIHDVKDYEELKQVVEGGWAFAWWCGSAACEAKVKEDTKATTRCIPLDQPGGAGRCVVCGEPATEKVYFARAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3T1</accession>
    <name>E8N3T1_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_10610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_10610"/>
    <dbReference type="EnsemblBacteria" id="BAJ63095">
        <property type="protein sequence ID" value="BAJ63095"/>
        <property type="gene ID" value="ANT_10610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_10610"/>
    <dbReference type="HOGENOM" id="CLU_1010636_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="275" mass="31438" checksum="B66E7A983ADE029C" modified="2011-04-05" version="1">MESMPAVSVIRLQEQITTLIGRLSHPMDFYRALTDFLETYGDHAYRAGERVTGESILPSYHVPPLVWRQLEVSLAQAARRFPQRTLDVIPLLWEAEYREPRHIAAWMLGHVPLSESSAVVEMLQRLVSLDVDWALLRVLLDKGTLTLRKEGEEPLLRMLETWLNREQPMYRKAGLLLCEGLVADPAWENLPAIFRLLQPLVEKPEPAWLNDLLIVLQNLAQRSPSEVSFFLKQILSRSEENPLTARLVRKVASSLPVEMAENLRKSARSSFPKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X3</accession>
    <name>E8N3X3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glycosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_11030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559527.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63137">
        <property type="protein sequence ID" value="BAJ63137"/>
        <property type="gene ID" value="ANT_11030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11030"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005603_0_0_0"/>
    <dbReference type="OMA" id="QDGYGPD"/>
    <dbReference type="OrthoDB" id="45650at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019248">
        <property type="entry name" value="Glucodextran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09985">
        <property type="entry name" value="Glucodextran_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003228620" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_57" evidence="4">
        <location>
            <begin position="59"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Glucodextran_C" evidence="5">
        <location>
            <begin position="793"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115801" checksum="963FE9B9B4E3EDF0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>E8N3X6</accession>
    <name>E8N3X6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_11060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559530.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63140">
        <property type="protein sequence ID" value="BAJ63140"/>
        <property type="gene ID" value="ANT_11060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11060"/>
    <dbReference type="HOGENOM" id="CLU_1431854_0_0_0"/>
    <dbReference type="OrthoDB" id="2170802at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="189" mass="20542" checksum="E7B6C5104434B0F9" modified="2011-04-05" version="1">MNRKTILIIVGVLAVVCLCIAGVGIIALNRAGKLISESASTDPVKIAQTASQIADYTLPQGYKEAFAMSFLNITMAGFTNESQGMTIFLFQMPAEAGLSSEQMREQMQQAIEAQTGKRYNLEYVGSENVTIRGQATELLTYEGTTDQGEAVRQMMGLFDGKNGTAWLMIIGKPNAWDQAGVDAFIRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>E8N440</accession>
    <name>E8N440_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpB</name>
        <name evidence="5" type="ordered locus">ANT_11700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_11700"/>
    <dbReference type="EnsemblBacteria" id="BAJ63204">
        <property type="protein sequence ID" value="BAJ63204"/>
        <property type="gene ID" value="ANT_11700"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_11700"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_3_0"/>
    <dbReference type="OMA" id="HHTASGY"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01804">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="191" mass="20880" checksum="E70BB922174FDA5F" modified="2011-04-05" version="1">MSEKQTLNNPVSPILPMVEALLFVAPGPVTSTQLAQALEVPVEMVEEALQALQQTYQQGRGLSLQWHSGRVQLTTAPHTAEAVERFLGLEATARLSRAALETLAIIAYRQPITRPAIDAIRGVNSDGVLKSLLNKGLVEEVGRAEAPGRPILYGTTSEFLQHFGLSSLKDLPPYDQQEEETSKQENLILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N476</accession>
    <name>E8N476_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_12060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559628.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12060"/>
    <dbReference type="EnsemblBacteria" id="BAJ63240">
        <property type="protein sequence ID" value="BAJ63240"/>
        <property type="gene ID" value="ANT_12060"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12060"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114057_1_2_0"/>
    <dbReference type="OMA" id="GPRPMEM"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="138" mass="15039" checksum="1C99DFED82B25A31" modified="2011-04-05" version="1">MDAKATWKHGLSFEGWASSGFTVNLGAAPEVGGENDGFRPMELLLVGLAGCTAMDVISILEKKRQQVTGFEVRAHAERANEHPKVFTEITLEYIVTGHNIDPEAVKRAVELSENKYCSAQAMLGKTANIQHKITILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4B8</accession>
    <name>E8N4B8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">ANT_12480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12480"/>
    <dbReference type="EnsemblBacteria" id="BAJ63282">
        <property type="protein sequence ID" value="BAJ63282"/>
        <property type="gene ID" value="ANT_12480"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12480"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515496_0_0_0"/>
    <dbReference type="OMA" id="VKWMEAS"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="335"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="528" mass="58579" checksum="842CBB31D73422C5" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4C0</accession>
    <name>E8N4C0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_12500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559672.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_12500"/>
    <dbReference type="EnsemblBacteria" id="BAJ63284">
        <property type="protein sequence ID" value="BAJ63284"/>
        <property type="gene ID" value="ANT_12500"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_12500"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="10"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="221"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="275" mass="31093" checksum="396C1FB7AEFBBC39" modified="2011-04-05" version="1">MKKGIVKNWMSSPVYTVTPETFIVDARRLLDVRKIRHLPVVSAGKLVGIVTRRGLLRADLPAVSDETWEIAFDLHHQTIRDIMTVNPITVFPNTPMPKAARVMLENKITGLPVLNDQRELVGILTSSDIFRFIIEELEEPLVVAEYMSEEVVVVEPDTSLLEAHRLMGTKRIRALPVLEEDRLVGLVTRTDLVSSDPSRFISRKQQELSLKILTQPVEGIMTRTLVTVSPQTTLKEAARLLLEKKIHSLPVVENSKLVGILTESDLFRMVVQKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4H2</accession>
    <name>E8N4H2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TP_methylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_13020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13020"/>
    <dbReference type="EnsemblBacteria" id="BAJ63336">
        <property type="protein sequence ID" value="BAJ63336"/>
        <property type="gene ID" value="ANT_13020"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13020"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_4_1_0"/>
    <dbReference type="OMA" id="MSEAGCP"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="227" mass="25382" checksum="E3FED8BFED5234F9" modified="2011-04-05" version="1">MIKEMSERKGQLYVVATPIGNPKDITLRAVEVLQNVQAIICEEHRIGSTLLKKLGIQKEIIVLNEHNEAEKAPDVARRILMGESMALISDCGTPVFADPGASLIAHLAEWEVPVTPIPGPSSLMAALSVLDFRLERFHYAGFLPRDKTERRNTLRGLRNLRVPIVVMDTPYRLMQVLDDVASVFGGNARITLCLDLTLPGETIFRGKIDEVQHKIKEKKSEFILIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4H7</accession>
    <name>E8N4H7_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">uppP</name>
        <name evidence="15" type="ordered locus">ANT_13070</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559729.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13070"/>
    <dbReference type="EnsemblBacteria" id="BAJ63341">
        <property type="protein sequence ID" value="BAJ63341"/>
        <property type="gene ID" value="ANT_13070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13070"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_0"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="BAJ63341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="273" mass="29759" checksum="9DD317B32CF6B233" modified="2011-04-05" version="1">MTLLEAIILGIVQGLTEFLPISSSAHLVIVPALFGWKLDPQIVFPFDVIIQVGTLVAVIAYFWQDLWKILIAWMRGIQHRNLFETPDARLGWYILLATLPASIAGVFLKSAVEAAFHSLTTTASFLLGTAVLLFLAEMLGKRTRSLSQMNALDAIVSGFFQALAIFPGISRSGSTITGGLLRGLDRPSAARFSFLMSIPIMLAAGAMEGLNLIREPGLWEFLPQLSAGFITAAIVGYASIHWLLGYLQRHSLRSFALYCLVVGAGILAWQILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4R3</accession>
    <name>E8N4R3_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_13990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_13990"/>
    <dbReference type="EnsemblBacteria" id="BAJ63427">
        <property type="protein sequence ID" value="BAJ63427"/>
        <property type="gene ID" value="ANT_13990"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_13990"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_1_0_0"/>
    <dbReference type="OMA" id="ACPAIER"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="184"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="30835" checksum="6AC1CA7ADCAA3660" modified="2011-04-05" version="1">MLSIPPIEPIDYLLIGHVTRDLTPEGPRVGGTATYSGLTARALGLRVGVVTACDSCFEIPRPSQYTVVGLHSPETTTFENIQTPQGRVQKIHQRAPGLGLSLVPETWRSAPIVHLGPVANEVDPGLVRAFPNALVGLTPQGWLRAWDQDGNVHFTDWLEAGFVLEQATAAVISIEDVRGDESYIEEFASHIRILAVTEGPQGARIYWNGDVRRFTPPKMREIDPTGAGDIFAAAFFIRLYTTRDPWEAGRFATQLAAYSVARPGLEGIPTPEEIQLCLTEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4S2</accession>
    <name>E8N4S2_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">clpB</name>
        <name evidence="12" type="ordered locus">ANT_14080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559818.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14080"/>
    <dbReference type="EnsemblBacteria" id="BAJ63436">
        <property type="protein sequence ID" value="BAJ63436"/>
        <property type="gene ID" value="ANT_14080"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14080"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_0"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="410"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="BAJ63436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="861" mass="96879" checksum="703798496F74BCB0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T8</accession>
    <name>E8N4T8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_14240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559834.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14240"/>
    <dbReference type="EnsemblBacteria" id="BAJ63452">
        <property type="protein sequence ID" value="BAJ63452"/>
        <property type="gene ID" value="ANT_14240"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14240"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034270_0_0_0"/>
    <dbReference type="OMA" id="TAPGANW"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="20"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="523" mass="57173" checksum="CB8185ABC582496B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4T9</accession>
    <name>E8N4T9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14250"/>
    <dbReference type="EnsemblBacteria" id="BAJ63453">
        <property type="protein sequence ID" value="BAJ63453"/>
        <property type="gene ID" value="ANT_14250"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14250"/>
    <dbReference type="HOGENOM" id="CLU_985692_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="282" mass="30972" checksum="66B02C117BD20296" modified="2011-04-05" version="1">MACDLFLSMTIIYLMTNRLARVAVGIAVGGLMGGLYAFLSQAINGLFLPGVPLKPSGAGSFLEFIWRYFLSGALLGGVASFPESKWLGTFLGGFAGALGVTLLGISSLRGGEERALGLFVMAFYLFLPLVVMYMSFAYLVRLGVNSQFPDPQHPELWARRFLVPLLLLILVIFVSAFSLYGRAERKAFQTVHQMVEEARKATNVQSLPVSFQSIQGYLENARGAYFLSLSDRVDLFMGPQPVNSPLSQFLIVGEFENGFSFACLFQGEQTIVPYCTNFSFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N4Y2</accession>
    <name>E8N4Y2_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_14680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559878.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63496">
        <property type="protein sequence ID" value="BAJ63496"/>
        <property type="gene ID" value="ANT_14680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14680"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="OMA" id="ETWYAMS"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="338" mass="36808" checksum="D124DA708BDF53CE" modified="2011-04-05" version="1">MLQAVMVEPGKIEFHEVEKPVPAKNEVLIAIQRIGVCGSDIHVYHGKHPYTSYPVVQGHEVSGIVAGVGNGVQDFMPGDKVVFMPQVTCGQCYPCQHGMEHICESLKVMGFQTGGAAQEYFPVDARKVLKLPNGVSLDEGAMVEPVSVAVHALRRGGFVPGMKVLVLGAGTIGNLVAQVARAQGASKVLVTDIQDYKLEKARECGLTGINTSRENLPHTIDEVFGKEKADLILECVGVQPTITQAIQVARKGTPIVVVGVFAEKPVVDLGLVQDRELSLVGTLMYQRPDYEKAIELIASHALMLQPLITHRFPFQDYLKAYQAIEESQGHYMKVMIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N504</accession>
    <name>E8N504_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_14900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559900.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14900"/>
    <dbReference type="EnsemblBacteria" id="BAJ63518">
        <property type="protein sequence ID" value="BAJ63518"/>
        <property type="gene ID" value="ANT_14900"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14900"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266759_0_0_0"/>
    <dbReference type="OrthoDB" id="809847at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="746"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1240" mass="139509" checksum="299C0ECA284B4569" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>E8N505</accession>
    <name>E8N505_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactokinase</fullName>
            <ecNumber evidence="7">2.7.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">galK</name>
        <name evidence="7" type="ordered locus">ANT_14910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.6" evidence="7"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559901.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63519">
        <property type="protein sequence ID" value="BAJ63519"/>
        <property type="gene ID" value="ANT_14910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14910"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_8_0_0"/>
    <dbReference type="OMA" id="SSWKWLQ"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="6">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="436" mass="47976" checksum="9A9D0A438D01D208" modified="2011-04-05" version="1">MALLLPLYRRFKTSLFPNWFSQLYGQDPARLQEEQTRWLNLLSRFQQRFPGVEQAALFSTPGRTEVGGNHTDHNQGRVLAAAVDRDVIAVAAPASDGKIILASEGYPLLEVDTRDLSVHPNERGTTPALVRGVCARLAQLGYAVGGFRAVMTSSVPKGSGLSSSAAFEVAVATILNHLYNGGRIPALTCAQIGQYAENVYFGKPCGLMDQTAAAVGGFVSIDFAEPEHPAVHQVHYDFAHSGYEVIIVETGGDHADLTADYASIREDMQAVAAFFGKHVLREVSREELLRHLAELRRQVHDRAILRALHFFDDNQRVEEQVAALEANRFDQFLRLVRESGRSSWMLLQNGFSHRKPEHQGIPLAQAISEILLGERGAWRVHGGGFAGTIQAFVPKDQANEYIQRMEAVFGRGSCYPVSIRQAGSVRLDDGEGDSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N557</accession>
    <name>E8N557_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_15430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013559953.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_15430"/>
    <dbReference type="EnsemblBacteria" id="BAJ63571">
        <property type="protein sequence ID" value="BAJ63571"/>
        <property type="gene ID" value="ANT_15430"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_15430"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_1_1_0"/>
    <dbReference type="OMA" id="YDSVVPH"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="206" mass="22950" checksum="954E8C7E60B4D11D" modified="2011-04-05" version="1">MEGFDKQAESIDVGQRLRALREERNISIRALARLSGLSANALSMIERGMTSPSVSTLNKLAIALKVPVTAFFRTMPVKEAVVFRKASERTRIPFLRGMMEGLGGEHFIGRVEAFLLTLENGGNSGPSYIVHSGHELVFCLRGKLEYDVEGKTYLLEPGDSMLFSASLKHRWRNSGTTVVNALIVISGFHEEEYPFEYHLSNLSQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5F0</accession>
    <name>E8N5F0_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_16380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560044.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16380"/>
    <dbReference type="EnsemblBacteria" id="BAJ63664">
        <property type="protein sequence ID" value="BAJ63664"/>
        <property type="gene ID" value="ANT_16380"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16380"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_0_2_0"/>
    <dbReference type="OMA" id="DRQISWP"/>
    <dbReference type="OrthoDB" id="1503081at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="154" mass="17340" checksum="BC03AEE0D33BEF3D" modified="2011-04-05" version="1">MTFTSPAIEFLRQKDISFSLFVQPDGLTMLDEIARFRGQRVSQIVRSLVFRYSEKKYALVLAQAGRNVNWKSLRAVLRVRRIAMATPEEVFQVTGYVVGAVSPFGLAQNLPVLVDQKILREEVVSTGSGILNVAIIIRVDNLLRALDDYQLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H8</accession>
    <name>E8N5H8_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_16660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560071.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16660"/>
    <dbReference type="EnsemblBacteria" id="BAJ63692">
        <property type="protein sequence ID" value="BAJ63692"/>
        <property type="gene ID" value="ANT_16660"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16660"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_1_2_0"/>
    <dbReference type="OMA" id="RICITKV"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="2Fe-2S-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="BAJ63692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="701" mass="76320" checksum="8B560E15724C646B" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5I7</accession>
    <name>E8N5I7_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_16750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_014960.1"/>
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    <dbReference type="STRING" id="926569.ANT_16750"/>
    <dbReference type="EnsemblBacteria" id="BAJ63701">
        <property type="protein sequence ID" value="BAJ63701"/>
        <property type="gene ID" value="ANT_16750"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16750"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160060_0_0_0"/>
    <dbReference type="OMA" id="LRWFIRS"/>
    <dbReference type="OrthoDB" id="2016147at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="127" mass="15233" checksum="724D939624529154" modified="2011-04-05" version="1">MKTIKSFPVIGVVGPCTAGKSTLIRNLERHNIPARHIAQEHSYVEDMWQRLTHPDVLIFLDVSYPVSLKRRKFNWTEEEYLEQQRRLRHARAHCHFYLLTDPYTEEQVFQQVYEFLQKHFPLLIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5N9</accession>
    <name>E8N5N9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_17270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17270"/>
    <dbReference type="EnsemblBacteria" id="BAJ63753">
        <property type="protein sequence ID" value="BAJ63753"/>
        <property type="gene ID" value="ANT_17270"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17270"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="NWRGAVI"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
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        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="144" mass="16623" checksum="BF4B211440B35A0D" modified="2011-04-05" version="1">MNQLLHPNQPCTSQEAEEACTKAIHPSALRGIRAFNQGDYYAAHEELEIAWRAEKSVLRHVYRGILQIGLAYYHILRGNYRGAVKMFAYSRYWLSSFPDVCCGVHLEKLRQDAQKAESLLLKLGEENLSQFPKEFFKPIEMETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5R5</accession>
    <name>E8N5R5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-ketoacyl synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">ANT_17530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560157.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17530"/>
    <dbReference type="EnsemblBacteria" id="BAJ63779">
        <property type="protein sequence ID" value="BAJ63779"/>
        <property type="gene ID" value="ANT_17530"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17530"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_30_2_0"/>
    <dbReference type="OMA" id="KTGYPPE"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="971"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1721"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1916"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1916"/>
            <end position="1932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ63779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="2805" mass="308330" checksum="AEDF1E14E63C8AD0" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5T9</accession>
    <name>E8N5T9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-reducing hydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_17770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17770"/>
    <dbReference type="EnsemblBacteria" id="BAJ63803">
        <property type="protein sequence ID" value="BAJ63803"/>
        <property type="gene ID" value="ANT_17770"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17770"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028431">
        <property type="entry name" value="NADP_DH_HndA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43342:SF2">
        <property type="entry name" value="PTHR43342:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ63803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="205" mass="23007" checksum="3414A11ECA8543B1" modified="2011-04-05" version="1">MIIDHSCFERVNSCRFSRDIYIFCIQFMHSEQLMLKSITVPENDPIAIEEKRAIIDQILEQNKHLPGGLMVILNEVQSQIGFISEPMQQYIANKLHVPVSTVHGVVSFYSFFTTTPRGKHTIKFCMGTACYVGGTPQLIEKAKQVLGIDPGETTPDGQITLELCRCVGACSQAPVIVVDEEIQGRVRPNKFPQLLRLIQDEQKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5V8</accession>
    <name>E8N5V8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SufBD_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufD</name>
        <name evidence="3" type="ordered locus">ANT_17960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560200.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17960"/>
    <dbReference type="EnsemblBacteria" id="BAJ63822">
        <property type="protein sequence ID" value="BAJ63822"/>
        <property type="gene ID" value="ANT_17960"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17960"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_3_1_0"/>
    <dbReference type="OMA" id="PNCESHQ"/>
    <dbReference type="OrthoDB" id="422804at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="457" mass="51645" checksum="79BB89513CF336EB" modified="2011-04-05" version="1">MAIQETPRIVTRTRRADISKPKEFKFDQNLVDFNLPHPDLIAYRKEAWQNFQTFPMPSVQEEAWRRTDIRGLKADLFRLPREQEYKDLTPPPDELLQPLADGEHGGEIVLLPGKAQVQLDEELKKQGVIFTDYQSALREYPSLVTKILGKAVRTSDGKFAALAGALAHTGVFLYVPRNVHLKTPLHSLLWGPGTGLAYISHFLVYLEEGASATYVHEFASPTEMEQALHAGIVELYVGNGAQLTFVELQSWGEHVWNFTHERALVDRDGHLDWIFGAIGSHLTKNFSEIDLVGEGSTGKMSGFYFTDHDQHLDHDTQQNHLAPHTTSDLLFKGALIQESRSVWQGMIYVAPGAQKTDGYQANRNLVLSPKARADSIPGLEILADDVRCTHGATVGKIDEEQIFYLMARGISRPLAERLIVEGFFDPIMQRIPFEGVRQRFQRTIAEKMRVFDEQMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5W5</accession>
    <name>E8N5W5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560207.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18030"/>
    <dbReference type="EnsemblBacteria" id="BAJ63829">
        <property type="protein sequence ID" value="BAJ63829"/>
        <property type="gene ID" value="ANT_18030"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18030"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_4_2_0"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="277" mass="30654" checksum="DBB313950AB3A70F" modified="2011-04-05" version="1">MTTIWTDSTADLSPSLIERYTLSVIPLYVLLDDKTFLDGVEIQLPQLFDFVSRTGRLPKTSAASIGDFLKRFETPGPHVYIGISSQLSATLKNAILAKEHLGRDDIYIVDSLNLSTGIGMLAVEAAELRDSGYSAAQIAEEISQRVPKVRTSFIIDTLDYLYKGGRCSALQNLMGSLLSIRPIIEVRKDGTLGVRSKTRGARKKGLMSMVADFEKDLPQVWLKRVFITHTGCDEDAEFLKQELLSRAPIEEIHMTYAGSVIASHCGPNTIGILYRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>E8N631</accession>
    <name>E8N631_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sigA</name>
        <name evidence="8" type="ordered locus">ANT_18690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18690"/>
    <dbReference type="EnsemblBacteria" id="BAJ63895">
        <property type="protein sequence ID" value="BAJ63895"/>
        <property type="gene ID" value="ANT_18690"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18690"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_3_0"/>
    <dbReference type="OMA" id="YWWISEE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="175"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="254"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="343"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="409" mass="46870" checksum="55EF4B823E0B4F70" modified="2011-04-05" version="1">MTVTMDDALLNVVDEDEEYPVIARLIDLGRQKSYVTIDDILHFFPEAEQDVEQLEEAFAALMSAGIPYLEDEIVEEPAEEELEAHEEGAVEEEGEEKSLALDDLANIDTDDTIGLYLKEVSRVPLLTAEEEVELAQRIERGRMAREELARGNVSPKRRQELRRLIEDGWAAREHLITANSRLVISVAKKYMGRGVPFLDLIQEGNIGLIRATKKFDYRRGHKFSTYATWWIRQAVTRAIADQGRTIRVPVHMGDQINKLLRVQHQLTQRLGREPSVEELAEALDVPPRKVENMIQVARRPLSLETPTDDEEDSVLGDFIEDEEAPPPDDTATYNLLRQHLEEVLNTLPPREVRILQLRYGLLDGQAYTLEEVGRKMGVTRERVRQIEAQALSRLRHPSIRRKLRDYLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>E8N653</accession>
    <name>E8N653_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">ANT_18910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560294.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_18910"/>
    <dbReference type="EnsemblBacteria" id="BAJ63917">
        <property type="protein sequence ID" value="BAJ63917"/>
        <property type="gene ID" value="ANT_18910"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_18910"/>
    <dbReference type="eggNOG" id="COG2124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_1_0"/>
    <dbReference type="OMA" id="IFRRMKM"/>
    <dbReference type="OrthoDB" id="520970at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ63917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="453" mass="51322" checksum="975C354D49DF3A47" modified="2011-04-05" version="1">MAITKIPGPTNLTLLPKIGSIQSKPLDFLLWLYQTYGPVSRFQAFNTPVIHLADPEAVKHVLQENHRNYSKDTIQYHSLAIITGNGLLTNDGTGWLRQRRLAQPAFARGRLSHLDQIVIPSTQSLLTRWRQLPEAHLIDVDAEMMRLTLEIVGKALFSIDLSKDAPHLTEATLTTLDYIVYRVKTLTLIPTYLPLPRNRAFRKALKTLEEAVSQIIQQRRKDKVLGEDLLGMFLRARDEESGEGMSDRQIRDEVMTMLIAGHETVASALTWTWYLLSTHPEIENRLFEEVHTVLKGNPPSTKDLENLPYTAQVFTEALRLYPPAWLITRKAMGEDEILGYSIPPGAVIVISPYVIHRLKEHWENPEAFIPERFARDPEGTSHRFTFIPFGAGPRLCIGNQFAHIEARLILAGMTQKLRFTPPPKAPVVDALVTLRPRNGLHMSVVHRSSNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>E8N663</accession>
    <name>E8N663_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ordered locus">ANT_19010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560304.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19010"/>
    <dbReference type="EnsemblBacteria" id="BAJ63927">
        <property type="protein sequence ID" value="BAJ63927"/>
        <property type="gene ID" value="ANT_19010"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19010"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_0"/>
    <dbReference type="OMA" id="HTEKFEV"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="BAJ63927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="56" mass="6749" checksum="9B4319ED5482B784" modified="2011-04-05" version="1">MASKKKDIRPVITFACVDCKERNYTSQKNRRNDPGRLELKKYCPRCRKHTLHRETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6A8</accession>
    <name>E8N6A8_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c-type biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccmH</name>
        <name evidence="6" type="ordered locus">ANT_19460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Possible subunit of a heme lyase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CcmH/CycL/Ccl2/NrfF family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19460"/>
    <dbReference type="EnsemblBacteria" id="BAJ63972">
        <property type="protein sequence ID" value="BAJ63972"/>
        <property type="gene ID" value="ANT_19460"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19460"/>
    <dbReference type="eggNOG" id="COG3088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107187_2_2_0"/>
    <dbReference type="OMA" id="MANEYNQ"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005616">
        <property type="entry name" value="CcmH/CycL/Ccl2/NrfF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038297">
        <property type="entry name" value="CcmH/CycL/NrfF/Ccl2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03918">
        <property type="entry name" value="CcmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ63972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="163" mass="18605" checksum="A6C46AFCBE8D032D" modified="2011-04-05" version="1">MSMKRAHLWIFFGLVFLAVLSQIGYAQSPVPTPSDDEVNRIAKQLYCPVCENVPLDVCPTQACSEWRELIRQKLIEGMTEEQIKEYFVLHYGDRVLAEPPRRGLNWLVYILPVVIFLIAVVITVRILRSMRKPVAAMSSSSSALEISEEELKRIEEALKKQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6C3</accession>
    <name>E8N6C3_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_19610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560360.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19610"/>
    <dbReference type="EnsemblBacteria" id="BAJ63987">
        <property type="protein sequence ID" value="BAJ63987"/>
        <property type="gene ID" value="ANT_19610"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19610"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_1_0"/>
    <dbReference type="OMA" id="SARWIVM"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ63987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="232" mass="25969" checksum="1D7876E7B56CBED6" modified="2011-04-05" version="1">MPLDVSRIQAICFDIDGTLSDTDDEWAERVLKGISFLKGWVGEQRLRNLARWVVMEIESPGNLLYNLLDRLHLDDEASRLFNFFVRKFHPRPSRFRLISGMDKTLQTLAQYYPLAIVSARDEEATLAFLQQFDLTSLFQVIVSAHTCKFTKPFPDPILWAAEKLNVPPSACLMVGDTTVDIHAGKKAGAQTVGVLCGFGTHKELVCAGADLILETTSELAEILLKEKNSMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D0</accession>
    <name>E8N6D0_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19680"/>
    <dbReference type="EnsemblBacteria" id="BAJ63994">
        <property type="protein sequence ID" value="BAJ63994"/>
        <property type="gene ID" value="ANT_19680"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19680"/>
    <dbReference type="HOGENOM" id="CLU_573240_0_0_0"/>
    <dbReference type="OMA" id="TITTHYE"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="2">
        <location>
            <begin position="392"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="476" mass="54494" checksum="AD0DF5B76962EED3" modified="2011-04-05" version="1">MRTSALTLHSHKVWKHLPLLLQAGMEMVWASLWYTGLFSEQVRLPWWSIWLIFWAILALSYAIRLVMLTIKRRQPFFQVGFLIWALVAGIISLKLIFYYHVQIGWKAFLLSPWYALTGAEESFLPFFHILLVPLLIIRGIALANSIPEIRSAQIDFQTGLVGVLLFGLFYLPVQPNLSVTGLFLYLWLGLIVLSSARLYGVSAFRGGRVSAIDSAWVIGLVISAGLVILLGILSGIFFSSYIGKFLLQIFIVLIAILGGLLILLIFPLLIGIMRLLLMVFEIFGARMSDVQNAIQKALEQTQTFSVELIESQLKTFEALKIALPLLLLFVVLMAILVWLRQKNRSQTLVAEEDIQHEKPVLRLFSFNQRHRIKENKISPKQWLAVARIRRIYHQFEALCEQAGKPRHPSTTPSEFAEHAGNWFPHLKTEIDLITRTYVQVRYGEISETPDEWQTVLNAWKNVQHSLKRKKPARKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY02</accession>
    <name>E8MY02_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">ANT_22070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560602.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22070"/>
    <dbReference type="EnsemblBacteria" id="BAJ64233">
        <property type="protein sequence ID" value="BAJ64233"/>
        <property type="gene ID" value="ANT_22070"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22070"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_9_1_0"/>
    <dbReference type="OMA" id="LAFWRAP"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="131"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BAJ64233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="503" mass="54142" checksum="633DF06DB5EEEC2B" modified="2011-04-05" version="1">MDAGRALLLLLLIPLAASPVIYLIGRLSVLRRGNGLWFARWFTLIAYLGMSFPLYTLGRYVLEIGPVDLKIGRIVLQMDGVGLFLAITVWVLSTLVTIFSFPYIRGEEDEEKYYALLPALSATMIGLGCTRDLFNLWVWFEAMAITSYLLVAFYHHQKGALEATVKYLVQSAVGSIMILHGISLVFAKTMTLDLQEIPSLMADSGLFGLAAGALFVVGFGVKIALAPLHTWLPDAHSRAPSGISAMLSGVVIESGLVALLRALGALSQVSSAWGALLLAFGAINMLIGNLMALRQEEVKRMLAYSSVAQVGYMLVGFGVAMAYGIADGAEGGFYHLFNHALMKGLAFLAVGAFLYALYITKGSHAPLMVSDLDGASKKYPLTAFALSVALLALGGLPPLAGFVSKWQIFVAGAEVRSTPLLWLIIFAGLNSVLSLGYYAPLINRMYRNQPSEVVQHGQPIALLISLPLLVLTFAIVLIGFFPGWMMPLNASAASGFLSAFGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY18</accession>
    <name>E8MY18_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-methionine-sulfoxide reductase catalytic subunit MsrP</fullName>
            <ecNumber evidence="5">1.8.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">msrP</name>
        <name evidence="7" type="ordered locus">ANT_22230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:51296"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + H2O + L-methionyl-[protein] = a quinol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:51292"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="5">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell envelope</location>
        </subcellularLocation>
        <text evidence="5">Is attached to the cell membrane when interacting with the MsrQ subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MsrP family.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.-" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_22230"/>
    <dbReference type="EnsemblBacteria" id="BAJ64249">
        <property type="protein sequence ID" value="BAJ64249"/>
        <property type="gene ID" value="ANT_22230"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_22230"/>
    <dbReference type="eggNOG" id="COG2041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045520_0_0_0"/>
    <dbReference type="OMA" id="WPYTEGL"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031975">
        <property type="term" value="C:envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016672">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01206">
        <property type="entry name" value="MsrP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022867">
        <property type="entry name" value="MsrP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="SSF56524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Oxidored_molyb" evidence="6">
        <location>
            <begin position="93"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Molybdopterin binding" evidence="5">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Molybdopterin binding" evidence="5">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="BAJ64249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="307" mass="35307" checksum="6B19291380EBA2A6" modified="2011-04-05" version="1">MHMEKIPSSEITPEHVYFSRRRFLREGALLAGAALLAACAPQISRESALTASTPTPMPDRPNTYEEITNYNNFYEFSFSKEAVAKLSAGLVTSPWEVRVEGLVRNPGIYDLDKIRKMFDQEERIYRLRCVEGWSMVIPWVGFPLHKLLKIVEPASEARFVQFTTLYDPQQMPGQKNKMFEWPYVEGLRMDEAMHDLTILATGIYGKDLLPQNGAPIRLVVPWKYGFKSIKSIVKIELKADMPPTFWSEASPDEYGFYANVNPEVPHPRWSQASERRIGESGRRPTLKFNGYDEVAPLYEGMDLRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2020-02-26" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>E8MY93</accession>
    <name>E8MY93_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_00040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_00040"/>
    <dbReference type="EnsemblBacteria" id="BAJ62038">
        <property type="protein sequence ID" value="BAJ62038"/>
        <property type="gene ID" value="ANT_00040"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_00040"/>
    <dbReference type="HOGENOM" id="CLU_3179502_0_0_0"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="46" mass="5269" checksum="97215C13B8CAC8B4" modified="2011-04-05" version="1">MSLRAPERGEAIPVNKGIASFPTVEIFRNDTFYFLEPLFNQVIIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>E8MZQ6</accession>
    <name>E8MZQ6_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">ANT_25780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ64604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_25780"/>
    <dbReference type="EnsemblBacteria" id="BAJ64604">
        <property type="protein sequence ID" value="BAJ64604"/>
        <property type="gene ID" value="ANT_25780"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_25780"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_0"/>
    <dbReference type="OMA" id="IWREAGW"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="103"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAJ64604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="330" mass="37629" checksum="CF91759D7D2979A0" modified="2011-04-05" version="1">MEQFIRPVRRNCSAHSFPKNCKLNQTPLVSYKKDMQKHSDRISYFVMIFPGLVLLIAFTFVPLFYSVIAFQKFNPALGIQNSPWVGLENFLYIFRVRDAQQVFFNTIFIAVMKIILLELAAIVFALLLNDLRYLHVKRTVQTMVYLPHFLSWVILAGILRTVLARNGLLNDFLGWFGVGPVYFLGRPDLFPWVIILSDVWKEFGFEAILYLAALTTIDPTLYEVAELDGANRFQKMWYISIPGILPTIVLVASLSLGNILNAGFDQIFNLYSPIVYSTGDILDTYVYRIGLIQGQYSIGTAVGLLKTVVSLILIGISYWIAGKFANYRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>E8N111</accession>
    <name>E8N111_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative gamma-glutamyltranspeptidase</fullName>
            <ecNumber evidence="1">2.3.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">ANT_05220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ62556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013558952.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_05220"/>
    <dbReference type="MEROPS" id="T03.025"/>
    <dbReference type="EnsemblBacteria" id="BAJ62556">
        <property type="protein sequence ID" value="BAJ62556"/>
        <property type="gene ID" value="ANT_05220"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_05220"/>
    <dbReference type="eggNOG" id="COG0405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_3_1_0"/>
    <dbReference type="OMA" id="GCKLAMA"/>
    <dbReference type="OrthoDB" id="803717at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="BAJ62556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="546" mass="58460" checksum="09C1216CFF200053" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>E8N2Y9</accession>
    <name>E8N2Y9_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW</name>
        <name evidence="2" type="ordered locus">ANT_31130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ65139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013561480.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_31130"/>
    <dbReference type="EnsemblBacteria" id="BAJ65139">
        <property type="protein sequence ID" value="BAJ65139"/>
        <property type="gene ID" value="ANT_31130"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_31130"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_4_0"/>
    <dbReference type="OMA" id="MPQYVEG"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="BAJ65139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="150" mass="16731" checksum="D0FEEAD9CDA7C3CD" modified="2011-04-05" version="1">MPHLEPYILFTIGETTYGVPSEHIQQMEMIEQITRVPNAPAFVDGVVYLRGKVLPVVNLRARFGLERIPYDLHARLIVVKLGERLVGMAVDSAREFVRLDSEQIQPPPPALQAAGNRFIAGVIPLQSRLVLILNLEEVLSPDEKAQLTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>E8N501</accession>
    <name>E8N501_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="5">SHMT</shortName>
            <shortName evidence="5">Serine methylase</shortName>
            <ecNumber evidence="5">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">glyA</name>
        <name evidence="8" type="synonym">gcvT</name>
        <name evidence="8" type="ordered locus">ANT_14870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_14870"/>
    <dbReference type="EnsemblBacteria" id="BAJ63515">
        <property type="protein sequence ID" value="BAJ63515"/>
        <property type="gene ID" value="ANT_14870"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_14870"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290304_0_0_0"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="6">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SHMT" evidence="6">
        <location>
            <begin position="97"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T" evidence="7">
        <location>
            <begin position="652"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="BAJ63515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="1054" mass="115973" checksum="A5F1792E015ABB91" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5H5</accession>
    <name>E8N5H5_ANATU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rlmN</name>
        <name evidence="13" type="ordered locus">ANT_16630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_16630"/>
    <dbReference type="EnsemblBacteria" id="BAJ63689">
        <property type="protein sequence ID" value="BAJ63689"/>
        <property type="gene ID" value="ANT_16630"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_16630"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_0_2_0"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="106"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="357" mass="40498" checksum="58C68195BE46721E" modified="2011-04-05" version="1">MDREITMSERPLIYDFDLEDLQNILVAWGEPPFRAKQVWEGLYHSFWNSPEEFTHLPKTLRNRLAEEFSFSHLSPIQTYASEDGETSKTLFHLPDNRSIETVLMRYKERRTLCISTQSGCAMGCVFCATGQMGFGRHLSSGEIVEQVIYFARLLRKTNEVVTNVVVMGMGEPFHNYENTLKAIARLNHPEGFNLGARRFTISTVGLVPMIERFAQENHQINLAISLHAANDTLRSSLLPVNKKYPISDLMRAVRQYVAQTGRRVTFEWALIRDINDSPEHARELASLLKGLLCHVNVIPLNPTQKYHGKATTRERAEAFCSILQKAGIPATIRLRRGIDIQAGCGQLATQHTQTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>E8N5U4</accession>
    <name>E8N5U4_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">ANT_17820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560186.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_17820"/>
    <dbReference type="EnsemblBacteria" id="BAJ63808">
        <property type="protein sequence ID" value="BAJ63808"/>
        <property type="gene ID" value="ANT_17820"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_17820"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_0"/>
    <dbReference type="OMA" id="CREGTDW"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="12">
        <location>
            <begin position="441"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAJ63808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="548" mass="59815" checksum="42F5A870746920ED" modified="2011-04-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-04-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>E8N6D5</accession>
    <name>E8N6D5_ANATU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">ANT_19730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1)</name>
        <dbReference type="NCBI Taxonomy" id="926569"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Chloroflexi</taxon>
            <taxon>Anaerolineae</taxon>
            <taxon>Anaerolineales</taxon>
            <taxon>Anaerolineaceae</taxon>
            <taxon>Anaerolinea</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2010-12" db="EMBL/GenBank/DDBJ databases">
            <title>Whole genome sequence of Anaerolinea thermophila UNI-1.</title>
            <authorList>
                <person name="Narita-Yamada S."/>
                <person name="Kishi E."/>
                <person name="Watanabe Y."/>
                <person name="Takasaki K."/>
                <person name="Ankai A."/>
                <person name="Oguchi A."/>
                <person name="Fukui S."/>
                <person name="Takahashi M."/>
                <person name="Yashiro I."/>
                <person name="Hosoyama A."/>
                <person name="Sekiguchi Y."/>
                <person name="Hanada S."/>
                <person name="Fujita N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AP012029">
        <property type="protein sequence ID" value="BAJ63999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_013560372.1">
        <property type="nucleotide sequence ID" value="NC_014960.1"/>
    </dbReference>
    <dbReference type="STRING" id="926569.ANT_19730"/>
    <dbReference type="EnsemblBacteria" id="BAJ63999">
        <property type="protein sequence ID" value="BAJ63999"/>
        <property type="gene ID" value="ANT_19730"/>
    </dbReference>
    <dbReference type="KEGG" id="atm:ANT_19730"/>
    <dbReference type="eggNOG" id="COG1647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640377_0_0_0"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000008922">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="167"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAJ63999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008922"/>
        </source>
    </evidence>
    <sequence length="428" mass="48217" checksum="A1A7B964C92FF645" modified="2011-04-05" version="1">MIYYYQKILSHRLLAWAVLSVLAGVSLWVFHTAGFWNGFGVQCLVWGAVDGVIALLGLRGLREKLESSPKFEVVRRDAARLRKILWVNAALDVLYLSGGLWILLKFPTDAWLQGTGAGVLVQGGFLLLFDVFHAIRVPEEVALPDLGILKGEEHQEFVLSGGDPVAILIHGFPGTPAEVREWAQAIHQEGWTVKALLLPGFGADLPNMYQQRVQMWLDKITAEVEVYKSQGRLVLLAGFSMGGGLSIVAAEKSQPHALLLLAPFWLPETIWTRLLAGIVRLFLPQVIYPFKSMPALLEQMKEEAHRAASDVNLDDPRLRIAVQEIPVPLITLEQFRVLSRWVRRSAPRLSMPVCILQGTRDPVVRPAFTQKLIQLMRTPVEYHLVSGEHHTLLRGEEGFEETMVLSRQFVRKVWMQYQHQKSSSFLSQ</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>